CN105267639A - Pharmaceutical preparation used for treating chronic gastritis - Google Patents
Pharmaceutical preparation used for treating chronic gastritis Download PDFInfo
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- CN105267639A CN105267639A CN201510829078.9A CN201510829078A CN105267639A CN 105267639 A CN105267639 A CN 105267639A CN 201510829078 A CN201510829078 A CN 201510829078A CN 105267639 A CN105267639 A CN 105267639A
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Abstract
The invention belongs to the field of traditional Chinese medicinal preparations and in particular relates to a pharmaceutical preparation used for treating chronic gastritis. The pharmaceutical preparation used for treating the chronic gastritis is prepared from the following raw materials: 25 parts of euphorbia hypericifolia, 20 parts of potentilla multifida, 22 parts of Asparagus filicinus, 22 parts of lespedeza pilosa, 24 parts of radix ophiopogonis, 28 parts of adenophora tetraphylla, 26 parts of rhizoma corydalis, 15 parts of white paeony root, 25 parts of poria cocos, 28 parts of semen raphani, 15 parts of fortune eupatorium herb, 15 parts of rhizoma nardostachyos, 20 parts of pawpaws, 25 parts of frankincense, 20 parts of red peony root, 25 parts of costustoot, 20 parts of pinellia ternata, 15 parts of uncaria rhynchophylla and 5 parts of liquorice. The traditional Chinese medicinal preparation provided by the invention can be used for treating the chronic gastritis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic gastritis and its preparation method and application.
Background technology
Chronic gastritis means the various chronic gastric Mucosal inflammatory pathological changes that different pathogeny causes, and be a kind of commonly encountered diseases, its sickness rate ranks first in various gastropathy.Since fiberendoscope extensive use, primary disease understanding is significantly improved.Common chronic superficial gastritis, chronic erosive gastritis and chronic atrophic gastritis.The intestinal epithelial metaplasia of the latter's mucosa, often involves cardia, reduces, also can involve body of stomach, with the forfeiture of secreting acid gland, cause gastric acid, the minimizing of pepsin and endogenous factors with G cell loss and gastrin secretion.For this reason, be bursting to and develop the needs that more medicines for the treatment of chronic gastritis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic gastritis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic gastritis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: logical Herba Euphorbiae Humifusae 25 parts, Potentilla multifida L. 20 parts, fern Radix Asparagi 22 parts, Herba lespedezae pilosae 22 parts, Radix Ophiopogonis 24 parts, Radix Adenophorae 28 parts, Rhizoma Corydalis 26 parts, the Radix Paeoniae Alba 15 parts, 25 parts, Poria, Semen Raphani 28 parts, Herba Eupatorii 15 parts, Radix Et Rhizoma Nardostachyos 15 parts, Fructus Chaenomelis 20 parts, Olibanum 25 parts, Radix Paeoniae Rubra 20 parts, the Radix Aucklandiae 25 parts, the Rhizoma Pinelliae 20 parts, Ramulus Uncariae Cum Uncis 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic gastritis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic gastritis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment chronic gastritis medicine being used for the treatment of chronic gastritis.
Logical Herba Euphorbiae Humifusae, formal name used at school: Euphorbiahypericifolia is the plant of Euphorbiaceae Euphorbia.Be distributed in the ground such as Hainan, Jiangxi, Sichuan, Guizhou, Hunan, Guangxi, Guangdong, Yunnan of the torrid zone, the island of Taiwan, subtropical zone and China's Mainland, be grown on height above sea level 30 meters to 2, the area of 100 meters, normal growth is in shrubbery, wasteland, wilderness, roadside or field, at present by artificial introducing and planting: clearing away heat-damp and promoting diuresis, restrain antipruritic.Bacillary dysentery, enteritis, diarrhea, bleeding hemorrhoids; Eczema is controlled in external, allergic dermatitis, skin pruritus.The present invention is with all herbal medicine.
Potentilla multifida L. is Rosaceae potentilla plants Potentilla multifida L. PotentillamultifidaL., is used as medicine with whole herb with root.Autumn excavates, and cleans, dries, clearing away heat-damp and promoting diuresis, hemostasis, parasite killing.For hepatitis, enterobiasis, dysfunctional uterine hemorrhage, traumatic hemorrhage.
Fern Radix Asparagi is Liliaceae asparagus plant asparagus filicicum Ham AsparagusfilicinusBuch.-Ham., is used as medicine with tuber.Autumn excavates, and cleans, goes crust to dry or cook to dry in the shade.Nourishing the lung to arrest cough.For pulmonary tuberculosis chronic cough, lung abscess, pertussis, sputum with blood, bronchial asthma.
Herba lespedezae pilosae is pulse family Lespedeza plant Herba lespedezae pilosae Lespedezapilosa (Thunb.) Sieb.etZucc., is used as medicine with Herb.Xia Qiucai, dries.Heat clearing away eliminating stagnation, promoting blood circulation and stopping pain, line water detumescence.For lymphoid tuberculosis, cold abscess, deficiency-heat is not moved back, edema, waist hamstring osteodynia; Mastitis are controlled in external.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: chronic gastritis is modal gastropathy, belongs to the sick category such as Chinese medicine " gastric abscess ", " feeling of fullness ", " acid regurgitation ", " noisy ", " indigestion and loss of appetite ".The traditional Chinese medical science is thought, chronic gastritis many because of long-term feelings will unsuccessful, eating and drinking without temperance, work and rest is not normal, causes depression of liver-QI, dysfunction of the spleen in transportation, and gastral cavilty is become estranged, and gas virtual loss with the passing of time, thus causes all symptoms.Herba Euphorbiae Humifusae is led in the present invention, Potentilla multifida L., fern Radix Asparagi, Herba lespedezae pilosae, Radix Ophiopogonis, Radix Adenophorae heat-clearing and toxic substances removing, soothing liver and strengthening spleen, tonifying YIN nourishing the stomach are monarch drug, Rhizoma Corydalis, the Radix Paeoniae Alba, Poria, Semen Raphani, Herba Eupatorii, Radix Et Rhizoma Nardostachyos, Fructus Chaenomelis, Olibanum, Radix Paeoniae Rubra, the Radix Aucklandiae, the Rhizoma Pinelliae, Ramulus Uncariae Cum Uncis promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, tonifying YIN nourishing the stomach, promoting flow of QI and blood, treatment chronic gastritis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get logical Herba Euphorbiae Humifusae 25g, Potentilla multifida L. 20g, fern Radix Asparagi 22g, Herba lespedezae pilosae 22g, Radix Ophiopogonis 24g, Radix Adenophorae 28g, Rhizoma Corydalis 26g, Radix Paeoniae Alba 15g, Poria 25g, Semen Raphani 28g, Herba Eupatorii 15g, Radix Et Rhizoma Nardostachyos 15g, Fructus Chaenomelis 20g, Olibanum 25g, Radix Paeoniae Rubra 20g, Radix Aucklandiae 25g, Rhizoma Pinelliae 20g, Ramulus Uncariae Cum Uncis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get logical Herba Euphorbiae Humifusae 25g, Potentilla multifida L. 20g, fern Radix Asparagi 22g, Herba lespedezae pilosae 22g, Radix Ophiopogonis 24g, Radix Adenophorae 28g, Rhizoma Corydalis 26g, Radix Paeoniae Alba 15g, Poria 25g, Semen Raphani 28g, Herba Eupatorii 15g, Radix Et Rhizoma Nardostachyos 15g, Fructus Chaenomelis 20g, Olibanum 25g, Radix Paeoniae Rubra 20g, Radix Aucklandiae 25g, Rhizoma Pinelliae 20g, Ramulus Uncariae Cum Uncis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get logical Herba Euphorbiae Humifusae 25g, Potentilla multifida L. 20g, fern Radix Asparagi 22g, Herba lespedezae pilosae 22g, Radix Ophiopogonis 24g, Radix Adenophorae 28g, Rhizoma Corydalis 26g, Radix Paeoniae Alba 15g, Poria 25g, Semen Raphani 28g, Herba Eupatorii 15g, Radix Et Rhizoma Nardostachyos 15g, Fructus Chaenomelis 20g, Olibanum 25g, Radix Paeoniae Rubra 20g, Radix Aucklandiae 25g, Rhizoma Pinelliae 20g, Ramulus Uncariae Cum Uncis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, traditional Chinese medicine composition for treating chronic gastritis of the present invention clinical research
4.1 general data: this Chinese medicine composition is applied to clinical observation chronic gastritis case 60 example, 27 ~ 58 years old age.The shortest person of the course of disease 3 months, most elder reaches 4 years, average 2.2 years.
4.2 diagnostic criterias: the symptom of chronic atrophic gastritis, sign, without specificity, can not, as the foundation of diagnosis, be made a definite diagnosis main by gastroscope and gastric mucosa living tissue pathologic finding.
(1) age: many above middle age, the course of disease is long, often has chronic superficial gastritis medical history.
(2) symptom and sign: long-term ingestion is bad, gastral cavilty portion distension is uncomfortable, poor appetite, weak, become thin, anemia etc.
(3) 1. gastric mucosa color is thin out in gastroscopy; 2. under mucosa, blood vessel is shown in thoroughly; 3. duplicature is tiny even disappears; 4. when atrophic gastritis is with body of gland cervical region hyperplasia or intestinal epithelial metaplasia, the coarse injustice of mucous membrane surface, in graininess or nodositas, visible pseudopolyp is formed sometimes, and under mucosa, the feature of exposed vessel is often covered; 5. atrophy mucosa fragility increases, easily hemorrhage, and can have rotten to the corn stove; 6. atrophic gastritis simultaneously with the performance of chronic superficial gastritis, as congested erythema, can adhere to mucus, and reflective enhancing etc.
(4) the body of gland atrophy that pathologic finding is 1. intrinsic in gastric mucosa; 2. life is changed; 3. hypertrophy; 4. canceration.
(5) the lab testing 1. many anacidities of gastric analysis A type CAG patient or low acid, Type B CAG patient can normal or low acid; 2. pepsinogen measures pepsin reason cell secretes, and during atrophic gastritis, blood and the pepsinogen content in urinating reduce; 3. the G emiocytosis gastrin of serum gastrin determination gastric antrum portion mucosa.A type CAG patient, serum gastrin Chang Mingxian increases; Type B CAG patient Antral atrophy, directly affects G emiocytosis gastrin function, and serum gastrin is lower than normally; 4. immunologic test parietal cell antibody (PCA), intrinsic factor antibody (IFA), gastrin secretion cell antibody (GCA) measure, and can be used as the auxiliary diagnosis of atrophic gastritis and typing thereof.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 30 | 2 | 23 | 5 | 83.3 |
| Blank group | 30 | 1 | 1 | 28 | 6.7 |
Visible the present invention has good therapeutic effect to chronic gastritis, and toxic and side effects does not occur treatments period.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of chronic gastritis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: logical Herba Euphorbiae Humifusae 25 parts, Potentilla multifida L. 20 parts, fern Radix Asparagi 22 parts, Herba lespedezae pilosae 22 parts, Radix Ophiopogonis 24 parts, Radix Adenophorae 28 parts, Rhizoma Corydalis 26 parts, the Radix Paeoniae Alba 15 parts, 25 parts, Poria, Semen Raphani 28 parts, Herba Eupatorii 15 parts, Radix Et Rhizoma Nardostachyos 15 parts, Fructus Chaenomelis 20 parts, Olibanum 25 parts, Radix Paeoniae Rubra 20 parts, the Radix Aucklandiae 25 parts, the Rhizoma Pinelliae 20 parts, Ramulus Uncariae Cum Uncis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic gastritis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic gastritis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic gastritis medicine of chronic gastritis according to claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770728A (en) * | 2016-03-03 | 2016-07-20 | 冯字 | Medicinal preparation used for treating chronic gastritis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1606990A (en) * | 2003-10-13 | 2005-04-20 | 郑洪彬 | Stomach and intestine strengthening medicine |
| CN101693101A (en) * | 2009-09-28 | 2010-04-14 | 姜庥每 | Lanceolata radish seed decoction for treating chronic gastritis |
| CN104547683A (en) * | 2014-12-26 | 2015-04-29 | 江苏苏南药业实业有限公司 | Traditional Chinese medicine composition for treating chronic gastritis and preparation method of traditional Chinese medicine composition |
| CN105031497A (en) * | 2015-08-26 | 2015-11-11 | 南京正宽医药科技有限公司 | Medicinal preparation for treating chronic gastritis |
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- 2015-11-25 CN CN201510829078.9A patent/CN105267639A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1606990A (en) * | 2003-10-13 | 2005-04-20 | 郑洪彬 | Stomach and intestine strengthening medicine |
| CN101693101A (en) * | 2009-09-28 | 2010-04-14 | 姜庥每 | Lanceolata radish seed decoction for treating chronic gastritis |
| CN104547683A (en) * | 2014-12-26 | 2015-04-29 | 江苏苏南药业实业有限公司 | Traditional Chinese medicine composition for treating chronic gastritis and preparation method of traditional Chinese medicine composition |
| CN105031497A (en) * | 2015-08-26 | 2015-11-11 | 南京正宽医药科技有限公司 | Medicinal preparation for treating chronic gastritis |
Non-Patent Citations (1)
| Title |
|---|
| 张穗坚等: "香砂健胃汤治疗老年性慢性胃炎35例疗效观察", 《新中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770728A (en) * | 2016-03-03 | 2016-07-20 | 冯字 | Medicinal preparation used for treating chronic gastritis |
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Application publication date: 20160127 |