CN105055806A - Medicinal preparation for treating diarrhea - Google Patents
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- CN105055806A CN105055806A CN201510583401.9A CN201510583401A CN105055806A CN 105055806 A CN105055806 A CN 105055806A CN 201510583401 A CN201510583401 A CN 201510583401A CN 105055806 A CN105055806 A CN 105055806A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of Chinese medicinal preparations, and specifically provides a medicinal preparation for treating diarrhea. The medicinal preparation is prepared from the following raw materials: 26 parts of false lily of the valley, 20 parts of Japanese coniogramme rhizome or herb, 18 parts of goldencup hypericum, 25 parts of gigantism rhodobryum herb, 18 parts of clove, 15 parts of bighead atractylodes rhizome, 15 parts of plantain seed, 20 parts of astragalus, 25 parts of pinellia tuber, 20 parts of dried orange peel, 15 parts of cassia bark, 20 parts of parslane herb, 15 parts of medicinal evodia fruit, 15 parts of coptis root, 15 parts of Chinese angelica, 25 parts of kudzuvine root, 15 parts of longhairy antenoron herb and 5 parts of liquoric root. The medicinal preparation can be used for treating diarrhea.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of diarrhoea and its preparation method and application.
Background technology
Diarrhoea is a kind of common sympton, and refer to that defecation frequency is significantly more than the frequency be on ordinary days accustomed to, excrement matter is thin, and moisture increases, and every day, feces volume was more than 200g, or containing non-digest food or pus and blood, mucus.Diarrhoea is normal with symptoms such as defecation urgency sense, anus discomfort, incontinences.Diarrhoea point acute and chronic two classes.Sharply, the course of disease is within 2 ~ 3 weeks in acute diarrhea morbidity.Chronic diarrhea refer to the course of disease more than two months or the intermission in 2 ~ 4 weeks recurrent diarrhoea.For this reason, be bursting to and develop the needs that more medicines for the treatment of diarrhoea safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of diarrhea disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of diarrhoea, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Maianthemi Bifolii 26 parts, Coniogramme japonica (Thunb.) Diels 20 parts, Herba Hyperici Patuli 18 parts, Rhodobryum giganteum(Hook.) Par. 25 parts, Flos Caryophylli 18 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Semen Plantaginis 15 parts, the Radix Astragali 20 parts, the Rhizoma Pinelliae 25 parts, Pericarpium Citri Reticulatae 20 parts, Cortex Cinnamomi 15 parts, Herba Portulacae 20 parts, Fructus Evodiae 15 parts, Rhizoma Coptidis 15 parts, Radix Angelicae Sinensis 15 parts, Radix Puerariae 25 parts, Herba Lysimachiae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of diarrhoea, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of diarrhoea, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment anti-diarrhea drug being used for the treatment of diarrhoea.
Herba Maianthemi Bifolii is the herb of liliaceous plant Herba Maianthemi Bifolii, and Classification system is Maianthemumbifolium (L.) Fr.Schmidt, the present invention with all herbal medicine,
Coniogramme japonica (Thunb.) Diels is rhizome or the herb of Hemionitidaceae plant wind bifurcation Herba pteridii latiusculi.Promoting blood circulation and hemostasis, mass dissipating and swelling eliminating.For spitting of blood of coughing, have blood in stool, menoxenia, traumatic injury, mastitis, carbuncle furuncle and phyma poison.
Herba Hyperici Patuli is Hypericaceae hypericum Herba Hyperici Patuli HypericumpatulumThunb., with all herbal medicine.Summer adopts browse, and autumn fruit picking is real, and Herb can be adopted the whole year, using fresh herb or dry.Heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing, antipruritic.Herb: upper respiratory tract infection, hepatitis, dysentery, nephritis.Really: metrorrhagia, epistaxis.Leaf: skin pruritus is controlled in external, impetigo.Root: ascarifuge.
Rhodobryum giganteum(Hook.) Par. is the herb that Bryaceae plant warms up ground great Ye moss.Bryophyte, body is comparatively large, and emerald green or summary are breen, somewhat gloss.Acrid in the mouth is bitter, flat.Can tranquillizing and allaying excitement, clear away heart-fire improving eyesight.Control heart disease, neurasthenia, sexual impotence.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, diarrhoea is commonly called as " diarrhoea ", and the traditional Chinese medical science is thought, " has loose bowels originally, invariably due to taste." sick many because of being invaded by exogenous pathogen, as the heresy of damp and hot, heat-damp in summer, cold-damp; Feelings will hindered, and anxiety and rage causes the liver failing to maintain the normal flow of QI, and perverse and unreasonable manner criminal spleen forms has loose bowels; Eating and drinking without temperance, surfeit delicious food savoury, or the thing of unclean corruption of taking food, Herba Maianthemi Bifolii of the present invention, Coniogramme japonica (Thunb.) Diels, Herba Hyperici Patuli, Rhodobryum giganteum(Hook.) Par., Flos Caryophylli, the Rhizoma Atractylodis Macrocephalae, Semen Plantaginis, Radix Astragali clearing away heat-damp and promoting diuresis, invigorating the spleen and benefiting QI are monarch drug, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Cortex Cinnamomi, Herba Portulacae, Fructus Evodiae, Rhizoma Coptidis, Radix Angelicae Sinensis, Radix Puerariae, Herba Lysimachiae warming and recuperating the spleen and kidney, stopping diarrhea with astringents are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, clearing away heat-damp and promoting diuresis, invigorating the spleen and benefiting QI, warming YANG activating QI, warming and recuperating the spleen and kidney, stopping diarrhea with astringents, treatment diarrhoea successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Maianthemi Bifolii 26g, Coniogramme japonica (Thunb.) Diels 20g, Herba Hyperici Patuli 18g, Rhodobryum giganteum(Hook.) Par. 25g, Flos Caryophylli 18g, Rhizoma Atractylodis Macrocephalae 15g, Semen Plantaginis 15g, Radix Astragali 20g, Rhizoma Pinelliae 25g, Pericarpium Citri Reticulatae 20g, Cortex Cinnamomi 15g, Herba Portulacae 20g, Fructus Evodiae 15g, Rhizoma Coptidis 15g, Radix Angelicae Sinensis 15g, Radix Puerariae 25g, Herba Lysimachiae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Maianthemi Bifolii 26g, Coniogramme japonica (Thunb.) Diels 20g, Herba Hyperici Patuli 18g, Rhodobryum giganteum(Hook.) Par. 25g, Flos Caryophylli 18g, Rhizoma Atractylodis Macrocephalae 15g, Semen Plantaginis 15g, Radix Astragali 20g, Rhizoma Pinelliae 25g, Pericarpium Citri Reticulatae 20g, Cortex Cinnamomi 15g, Herba Portulacae 20g, Fructus Evodiae 15g, Rhizoma Coptidis 15g, Radix Angelicae Sinensis 15g, Radix Puerariae 25g, Herba Lysimachiae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba Maianthemi Bifolii 26g, Coniogramme japonica (Thunb.) Diels 20g, Herba Hyperici Patuli 18g, Rhodobryum giganteum(Hook.) Par. 25g, Flos Caryophylli 18g, Rhizoma Atractylodis Macrocephalae 15g, Semen Plantaginis 15g, Radix Astragali 20g, Rhizoma Pinelliae 25g, Pericarpium Citri Reticulatae 20g, Cortex Cinnamomi 15g, Herba Portulacae 20g, Fructus Evodiae 15g, Rhizoma Coptidis 15g, Radix Angelicae Sinensis 15g, Radix Puerariae 25g, Herba Lysimachiae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment diarrhoea of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation diarrhoea case 100 example, 28 ~ 49 years old age.The shortest person's two weeks of the course of disease, most elder reaches 2 months.
4.2 diagnostic criterias: diarrhoea, stool every day >=3 times, the character of feces is abnormal, can be loose stool, watery stool, also can be Mucous Stool, bloody purulent stool and hemafecia, can with Nausea and vomiting, inappetence, heating, stomachache and general malaise etc.The person of being in a bad way, because a large amount of moisture of losing causes de-water and rock-soil coupling even to suffer a shock.Cholera, bacillary and amebic dysentery, Typhoid and paratyphoid.
Lab testing: stool for routine inspection: feces can be loose stool, watery stool, hemafecia or bloody purulent stool.Microscopy can have volume red white corpuscle, also can have a small amount of or acellular.Etiological examination: the pathogenic microorganism beyond cholera, dysentery, Typhoid and paratyphoid can be detected in feces, as intestinal diarrheagenic E. coli, salmonella, rotavirus or Giardia lamblia etc.Or detect specific antigen, nucleic acid or detect specific antibody from serum.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: cure: stool is normal, and other transference cures, Clinical Laboratory is normal.Take a turn for the better: times of defecation obviously reduces, other symptoms are improved.Invalid: symptom has no improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 50 | 27 | 18 | 5 | 90 |
| Blank group | 50 | 3 | 4 | 43 | 14 |
Visible, the medicine that the present invention obtains can be suffered from diarrhoea in safe and effective treatment, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of diarrhoea, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Maianthemi Bifolii 26 parts, Coniogramme japonica (Thunb.) Diels 20 parts, Herba Hyperici Patuli 18 parts, Rhodobryum giganteum(Hook.) Par. 25 parts, Flos Caryophylli 18 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Semen Plantaginis 15 parts, the Radix Astragali 20 parts, the Rhizoma Pinelliae 25 parts, Pericarpium Citri Reticulatae 20 parts, Cortex Cinnamomi 15 parts, Herba Portulacae 20 parts, Fructus Evodiae 15 parts, Rhizoma Coptidis 15 parts, Radix Angelicae Sinensis 15 parts, Radix Puerariae 25 parts, Herba Lysimachiae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of diarrhoea as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of diarrhoea as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment anti-diarrhea drug of diarrhoea according to claim 1.
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| CN108392502A (en) * | 2018-05-24 | 2018-08-14 | 广西壮族自治区药用植物园 | Treat the precious jade medicine compound Guava Leaf mixture and preparation method thereof of diarrhea |
Citations (4)
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