CN104547922A - Chinese medicinal composition for treating prostatitis and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal composition for treating prostatitis and belongs to the technical field of traditional Chinese medicinal compositions. The Chinese medicinal composition comprises the following components in parts by weight: 50 to 80 parts of radices rehmanniae, 30 to 45 parts of the root bark of the peony tree, 55 to 65 parts of rhizoma alismatis, 50 to 65 parts of golden cypress, 60 to 80 parts of rhizoma anemarrhenae, 70 to 95 parts of dandelion, 75 to 100 parts of astragalus mongholicus, 50 to 65 parts of curcuma zedoary, 35 to 45 parts of peach kernel, 50 to 70 parts of fructus corni, 50 to 68 parts of yam, 50 to 75 parts of poria cocos, 20 to 30 parts of cinnamomum cassia, 15 to 30 parts of amber, 55 to 80 parts of rhizoma sparganii and 55 to 65 parts of stir-baked squama manitis. The Chinese medicinal composition has obvious treatment effects on prostatitis, scorching hot urethra, urinating obstruction and the like.

Description

One is used for the treatment of prostatitic Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to technical field of traditional Chinese medicine, be specifically related to one and be used for the treatment of prostatitic Chinese medicine composition and preparation method thereof, particularly relate to one and be used for the treatment of prostatitic Chinese patent medicine tablet.

Background technology

Prostate is an Accessory sexual gland maximum in genital orgnas,male.Prostatic fluid secreted by it is the important component part of seminal fluid.Prostate is the same with health other organs, also can be sick, and modal is chronic prostatitis.Clinical discovery, the male of 25%-50% suffered the puzzlement of this disease.At present, prostatitis, congestion of prostate and prostatodynia that prostatitis can be divided into non-specific bacterial prostatitis, idiopathic bacterial prostatitis, specific prostatitis (being caused by gonococcus, tulase, fungus, parasite etc.), nonspecific granulomatous prostatitis, other pathogen (as virus, mycoplasma, chlamydia etc.) to cause, modern medicine to it also without good prevention and treatment method.But motherland's medical science has obvious advantage in the preventing and treating of chronic prostatitis.Because prostatitic incidence rate is very high, this just requires must be popular to its means of prevention and method, to meet numerous prostatitis crowd demand.Therefore, seeking a kind of prostatitis prevention and controls that can play tcm characteristic popular is again desirability.

Summary of the invention

The invention provides a kind of for prostatitic Chinese medicine composition and preparation method thereof, this Chinese medicine composition is remarkable to the therapeutic effect that prostatitis, urethra scorching hot, urine are smooth etc.Described technical scheme is as follows:

Embodiments provide one and be used for the treatment of prostatitic Chinese medicine composition, its composition with parts by weight is: Radix Rehmanniae 50-80 part, Cortex Moutan 30-45 part, Rhizoma Alismatis 55-65 part, Cortex Phellodendri 50-65 part, Rhizoma Anemarrhenae 60-80 part, Herba Taraxaci 70-95 part, Radix Astragali 75-100 part, Rhizoma Curcumae 50-65 part, Semen Persicae 35-45 part, Fructus Corni 50-70 part, Rhizoma Dioscoreae 50-68 part, Poria 50-75 part, Cortex Cinnamomi 20-30 part, succinum 15-30 part, Rhizoma Sparganii 55-80 part, Squama Manis 55-65 part.

Preferably, its composition with parts by weight is: Radix Rehmanniae 60 parts, Cortex Moutan 40 parts, Rhizoma Alismatis 60 parts, Cortex Phellodendri 60 parts, the Rhizoma Anemarrhenae 60 parts, Herba Taraxaci 80 parts, the Radix Astragali 80 parts, Rhizoma Curcumae 60 parts, 40 parts, Semen Persicae, Fructus Corni 60 parts, Rhizoma Dioscoreae 60 parts, 60 parts, Poria, Cortex Cinnamomi 24 parts, succinum 24 parts, Rhizoma Sparganii 60 parts, Squama Manis 60 parts.

In order to improve the therapeutic effect of Chinese medicine composition, adopt the Chinese crude drug through concocting, as salt system, vinegar etc.Its composition with parts by weight is: Radix Rehmanniae 50-80 part, Cortex Moutan 30-45 part, Rhizoma Alismatis 55-65 part, stir-baked CORTEX PHELLODENDRI with salt solution 50-65 part, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 60-80 part, Herba Taraxaci 70-95 part, Radix Astragali 75-100 part, stir-baked RHIIZOMA CURCUMAE with vinegar 50-65 part, Semen Persicae 35-45 part, wine Fructus Corni 50-70 part, Rhizoma Dioscoreae 50-68 part, Poria 50-75 part, Cortex Cinnamomi 20-30 part, succinum 15-30 part, stir-baked RHIZOMA SPARGANII with vinegar 55-80 part, stir-baked SQUAMA MANITIS 55-65 part.

Preferably,, its composition with parts by weight is: Radix Rehmanniae 60 parts, Cortex Moutan 40 parts, Rhizoma Alismatis 60 parts, stir-baked CORTEX PHELLODENDRI with salt solution 60 parts, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 60 parts, Herba Taraxaci 80 parts, the Radix Astragali 80 parts, stir-baked RHIIZOMA CURCUMAE with vinegar 60 parts, 40 parts, Semen Persicae, wine Fructus Corni 60 parts, Rhizoma Dioscoreae 60 parts, 60 parts, Poria, Cortex Cinnamomi 24 parts, succinum 24 parts, stir-baked RHIZOMA SPARGANII with vinegar 60 parts, stir-baked SQUAMA MANITIS 60 parts.

Wherein, Chinese medicine composition can be the oral medicine such as tablet, powder, pill or decoction, is preferably tablet.

On the other hand, the embodiment of the present invention additionally provides a kind of compositions, be used for the treatment of prostatitic Chinese medicine composition and pharmaceutical carrier containing the above-mentioned of effective dose, pharmaceutical carrier can be specifically adjuvant, filler, syrup or spice etc., known by those skilled in the art.

On the other hand, the embodiment of the present invention additionally provides the preparation method of aforementioned Chinese medicine composition, comprises the following steps:

(1) decoct: get raw material Radix Rehmanniae, Cortex Moutan, Rhizoma Alismatis, Cortex Phellodendri, the Rhizoma Anemarrhenae, Herba Taraxaci, the Radix Astragali, Rhizoma Curcumae, Semen Persicae and Rhizoma Sparganii by proportioning, add the decocting 1.5-2.5 hour of raw material 4-6 times weight, filter, the decocting 0.5-1.5 hour of raw material 4-6 times weight is added in filtering residue, filter, merge twice filtrate, the decoction liquor after being combined concentrates, and is evaporated to the thick paste that 60 DEG C of relative densities (relative to water) are 1.20-1.25.

(2) grind: get Fructus Corni, Rhizoma Dioscoreae, Poria, Squama Manis, Cortex Cinnamomi and succinum by proportioning, be ground to 80-200 object fine powder, mixing obtains powder.

(3) granulate: get thick paste that step (1) obtains and the powder that step (2) obtains by proportioning, mixing, obtains tablet through porphyrize, alcohol granulation, drying, tabletted; Appropriate pharmaceutical carrier can be added as required in pelletization.

Wherein the using method of this tablet is: a 6-8 sheet, 3 times on the one.

In the Chinese medicine composition provided of the present invention key agents introduction and drug action mechanism as follows:

Radix Rehmanniae (Classification system: rehmannia glutinosa (Gaetn.) Libosch. ex Fisch. et Mey.), Chinese medicine is the fresh of scrophulariaceae rehmannia glutinosa plant or dried root.Cure mainly: there are enriching yin and nourishing kidney, nourish blood enrich blood, effect of removing heat from blood.All deficiency of YIN blood deficiency person who suffer from deficiency of kidney Yang eat it, quite helpful.In addition, Radix Rehmanniae has heart tonifying diuresis, antipyretic antiinflammatory, promotes blood coagulation and falls hypoglycemic effect.

Cortex Moutan, Chinese medicine name is the dry root bark of ranunculaceae peony.Modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has suppression Platelet; Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.Antiinflammatory action :use paeonol gavage, inhibitory action is had to the sufficient sole of the foot edema that rat causes because of dextran or acetic acid or carrageenin, and the mouse peritoneal that acetic acid or 5-hydroxy tryptamine can be suppressed to cause or guinea pig skin capillary permeability strengthen, and suppress the generation of mice stress ulcer.Experiment proves that the caused various inflammatory reactions such as Cortex Moutan water decoction on Carrageenan edema, adjuvant-induced arthritis and Arthus reaction are inhibited, this permeability with its inflammation-inhibiting tissue and suppress the biosynthesis of PGE2 relevant, Cortex Moutan can not suppress remaining adrenal compensatory hypertrophy, the ascorbic metabolism of adrenal gland is also had no significant effect, point out it both without the effect of class cortisone sample, without the effect of class thyroliberin sample, namely its antiinflammatory action does not rely on pitutary-adrenal system yet.I, II, Ⅲ type allergy is the reaction mediated by specific antibody, the formation of Cortex Moutan antagonist also has no significant effect, but to all have inhibitory action, may be played a role by non-specific anti-inflammatory mechanisms, and suppress SC active, also just strengthen its anti-inflammatory effect.Cortex Moutan does not suppress the generation of specific antibody, does not affect the hemolytic activity of alternative pathway of complement, and prompting Cortex Moutan, while performance antiinflammatory action, can not suppress normal body fluid immunologic function.Bacteriostasis: experiment in vitro shows, Cortex Moutan decoct all has stronger antibacterial action to bacillus subtilis, escherichia coli, Bacillus typhi, Salmonella paratyphi, Bacillus proteus, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, vibrio cholera etc., leaf of paeonia suffruticosa ardr. decoct has remarkable antibacterial action to dysentery bacterium, bacillus pyocyaneus and staphylococcus aureus, and its active ingredient is gallic acid.

Rhizoma Alismatis, Chinese medicine is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Cure mainly, for dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.

The Rhizoma Anemarrhenae, Chinese medicine name is herbaceos perennial, root stock..Cure mainly: calentura excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.

Herba Taraxaci, Classification system: taraxacum mongolicumhand.-Mazz., Compositae, Dandelion herbaceos perennial.Dandelion herb is rich in vitamin A, vitamin C and potassium, also containing ferrum, calcium, vitamin B2, vitamin B1, magnesium, vitamin B6, folic acid and copper.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant.Nature and flavor are sweet, micro-hardship, cold.Return liver, stomach warp.There are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Control pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc.

The Radix Astragali, latin name Astragalus membranaceus (Fisch.) Bunge., it has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting, and hyperactivity of YANG due to deficiency of YIN person, must prohibit clothes.

Rhizoma Curcumae, Latin name: Curcuma zedoaria (Christm.) Rosc., Rhizoma Curcumae is Zingiberaceae, Curcuma perennial root draft.Cure mainly that " lump in the abdomen, gathers, and dyspepsia does not disappear for coagulation of QI-blood, trusted subordinate's distending pain, and women's blood stasis amenorrhea, traumatic injury is had a pain.", there are promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.

Semen Persicae (Semen Persicae), can refer to the core youngster in Semen Persicae; When using as Chinese herbal medicine Semen Persicae, the seed refering in particular to rosaceous plant Fructus Persicae or Prunus davidiana has effect of blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, can be used for amenorrhea, dysmenorrhea, WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation etc.These product protein ingredient in two homogeneous protein ingredients, intravenous administration, xylol induced mice ear acute inflammatory reaction, all has remarkable inhibitory action.

Fructus Corni, formal name used at school: Cornus officinalis Sieb. et Zucc., mature fruit is Chinese medicine, and for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Fruit decoct can suppress the growth of staphylococcus aureus in vitro, then invalid to escherichia coli.A dark red tart flavour liquid can be obtained from fresh dogwood fruits meat, have inhibitory action to typhoid fever, dysentery antibacterial.Water logging agent (1:3) has inhibitory action in various degree to trichophyton in vitro.It has obvious bacteriostasis, and experimental data is as follows:

(1) mouse peritoneal capillary permeability is suppressed: male mice in kunming, body weight 18-22g.Positive controls ig every day aspirin 50mg/kg, administration group ig every day Fructus Corni 5,10g/kg(water decoction is containing crude drug 1g/ml), continuous 5d, blank group gives the water of equivalent every day, lh after last administration, the blue 5ml/kg of each Mus tail iv0.5%Evans, ip0.7% acetic acid 10ml/kg after 5min, by mice sacrificed by exsanguination after the 30min of interval, repeatedly abdominal cavity is rinsed with distilled water, collect flushing liquor and be diluted to 10ml and place lh, by 751 type spectrophotometer 610nm place colorimetrics, the standard curve dyestuff seepage discharge absorbed by Evans indigo plant, result matched group, aspirin group, Fructus Corni 5.10g/kg group dyestuff seepage discharge (ug/ml) is respectively 91 ± 1.6, 4.9 ± 2.5(P<0.01), 5.3 ± 2.0(P<0.01), 5.5 ± 2.8(P<0.01) (x ± S, n=10).The rat abdominal cavity capillary permeability increase that visible various dose Fructus Corni Dichlorodiphenyl Acetate causes all has obvious inhibitory action.

(2) dimethylbenzene induced mice auricle edema is suppressed: male mice in kunming, body weight 18-22g, administration group continuous 5dig Fructus Corni 10.20g/kg, 1h after last administration, dimethylbenzene 30ul is applied to mouse right ear exterior feature, left auricle compares, and cuts auricle and takes off auricle with diameter 9mm card punch, weigh after 2 hours.Result matched group, Fructus Corni 10.20g/kg group mice left and right auricle weight difference (mg) are respectively 18.2 ± 4.5,99 ± 4.5(P<0.01), 11.3 ± 4.3(P<001), (n=10).Show that Fructus Corni shows suppression dimethylbenzene induced mice auricle edema.

(3) the rat footpad swelling suppressing proinflammatory agent to cause: male SD rat, body weight 120-160g, positive controls, administration group be continuous 5dig aspirin 50mg/kg and Fructus Corni 5g/kg respectively, l hour after last administration, fresh albumen 0.1ml is become in Rat Right metapedes pad scl% carrageenin, cause scorching after per hourly measure a footpad swelling degree (mm) with caliper-gauge, result Fructus Corni 5g/kg has obvious inhibitory action to swelling caused by Ovum Gallus domesticus album, and footpad swelling caused by Carrageenan only shows in 1 little inhibitory action constantly.

(4) rat granuloma hamartoplasia is suppressed: male Wistar rat, body weight 150-220g, etherization, the heavy sterilized cotton ball of each heeling-in 20mg one under the forelimb axillary fossa of both sides, positive controls, administration group be continuous sc hydrocortisone 10mg/kg and ig Fructus Corni 5,10g/kg respectively, rat is in d8 sacrificed by exsanguination, peel off granulation tissue, 80 DEG C of bakings were weighed after 3 hours, and get each Mus thymus simultaneously, adrenal gland weighs.Visible Fructus Corni obviously suppresses rat granuloma hamartoplasia, to thymus and adrenal gland's weight without significant impact.

(5) reduce ascorbic acid content in adult rat adrenal tissue: get granuloma and test adrenal gland on the right side of rat used, make by 2 after homogenate, 4 one dinitrophenylhydrazine determination of color wherein ascorbic acid content.Fructus Corni 5,10g/kg all makes ascorbic acid content in adult rat adrenal tissue obviously reduce.

(6) on the impact of PGE content in rat inflammation tissue: male SD rat, body weight 150-180g.Administration group, positive controls is continuous 5dig Fructus Corni 10g/kg or indometacin 50mg/kg respectively, after last administration 30 minutes, in each Mus right back foot pad scl% carrageenin 0.1ml, put to death after 3 hours, right back foot lcm place on ankle joint is cut and weighs, peeling is placed in 5ml normal saline soaks lh, get supernatant 0.15ml and add 0.5mol/L methanolic potassium hydroxide liquid 1ml, at 50 DEG C of water-bath isomerization 20min, add methanol 2.5ml, ultraviolet absorption value (△ A) is measured in 278nm place, PGE content is represented with the absorption value that every gram of inflammatory tissue is suitable, result Fructus Corni 10g/kg causes scorching heavy sensation in the foot amount to rat and PGE content all has no significant effect.

Rhizoma Dioscoreae is the medical herbs that " Chinese draft " records, and medicinal source is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome.Have and nourish strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.

Poria, Chinese medicine name.For On Polyporaceae Poria poria cocos (Schw.) Wolfdry sclerotia.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Poria function promoting diuresis to eliminate damp pathogen, and mild in medicine property and, diuretic and do not hinder healthy energy is promoting diuresis to eliminate damp pathogen key medicine.The disease of all dysuria, retention of water-damp, no matter be partial to cold-damp, or relatively damp and hot, or belong to insufficiency of the spleen wet poly-, all can fit applications.As relatively cold-damp person, can with the compatibility such as Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae; Relatively damp and hot person, can with the compatibility such as Polyporus, Rhizoma Alismatis.

Succinum is that the resin before tens million of year is buried in underground, a kind of ambrite formed after certain chemical change.The various temper using succinum as main component is also widely used in treating the some diseases in hyperthyroidism, respiratory tract disease, bronchitis, asthma, heart disease, hypertension, bladder and gastroenteropathy and circulatory system.By the detection method of science, succinum contains the succinic acid of 3% ~ 8%, and this medicinal ingredient is used to modern medicine.Succinic acid mainly concentrates in succinum skin, that is to say the outermost layer of succinum Ore.Therefore, succinum tcrude ore, without throwing skin or the slight succinum goods (necklace, bangle and pendant) throwing skin can be brought treatment and sterilization.Up-to-date scientific research proves, succinic acid has active influence to human organ.It can enhancing immunity, make people energetic and the balance of holder inner acidic.Modern bacteriological advocate carried out careful analysis to succinic acid: the Nobel laureate in 1886, Germany bacteriologist Robert. section is conspicuous has affirmed the positive influences of succinic acid, he finds that the accumulation of the residue of succinic acid in human body can not bring any negative effect, or even to take into excessive succinic acid be also harmless.Social uphold nature medical science now, becomes more general with succinum as the medicine cosmetics of composition.Especially more than ten in the U.S. and Russian production and processing and plant the active drug containing succinic acid, and obtain patent.Succinic acid has the special medical value of human body cell senescence, and people use it as inhibitor (slow down or stop) and the antioxidant of potassium ion.Through scientific analysis, succinic acid can be called modern youth Herba Cynomorii.Succinic acid has very high value to athlete.It is the blender of balanced physical function development in an all-round way.In other plant, also once found succinic acid, this is a kind of indispensable composition of food.But because be difficult to find it in nature, often occur that succinic acid lacks.Even have peracid, all few than Baltic Sea succinum 1000 times of the acid contained in immature Fructus Mori, Radix Dauci Sativae and Caulis Rhei.Succinic acid has good effectiveness for recovery confined to bed and after sustaining a severe injury for a long time.The immunity that it makes patient likely recover disease, the power that also can warn is concentrated.Amber oil is generally acknowledged to the effective medicine of all rheumatisms.Ji Yakamo. Fan Teshi (nuncio) describes like this in the travel notes of 1652: " with succinum make a kind of very valuable, potent, taste is pained, the dense thick oil of texture.I takes back the prescription of this oil allotment from completing the cradle Ge Tansike refining this oil, it has the effect be highly profitable.The amber oil be made into white succinum is especially precious ... " amber oil promptly can penetrate to the skin down, be deep in cell tissue, play its effectiveness.Its energy blood circulation promoting, alleviates myalgia.

Rhizoma Sparganii, has another name called belt leather Rhizoma Sparganii.For the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganiuum stoloniferum Buch.-Ham..Swollen pain, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer swell hard down to control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body.

Cortex Phellodendri, has another name called bark of a cork tree skin, Cortex Phellodendri, for Rutaceae deciduous tree plant Cortex Phellodendri (Cortex Phellodendri) Phelloderdronamurense Rupr. and wampee (Cortex Phellodendri) P.chinense Schneid. removes the bark of cork.Bitter in the mouth, cold in nature.Enter kidney, bladder, large intestine channel.Cortex Phellodendri is heavy cloudy to decline, can excess-heat, reducing the asthenic fever clearly, and lays particular emphasis on reducing the minister-fire, reducing the asthenic fever, is used for the treatment of the diseases such as fever due to yin deficiency, osteopyrexia and fever, emission; Again can heat clearing and damp drying, eliminating fire and detoxication, be used for the treatment of jaundice due to damp-heat damp-heat diarrhea, pathopyretic ulcer, eczema, and the disease such as the leucorrhea with red and white discharge caused by damp invasion of lower energizer, sufficient swelling and pain in knee, pyretic stranguria (difficulty and pain in micturition).Dry damage liquid can be avoided, make heat clearing away and without the fraud of cold coagulation, macrophages release inflammatory cytokine can be suppressed, the secretions such as IL-1, TNF-α, IL-2, IFN-γ are reduced, thus the damage that reduces inflammation.

Cortex Cinnamomi is dried bark or the thick branch skin of Lauraceae aiphyllium plant Cortex Cinnamomi Cinamomum cassia Presl.Acrid in the mouth, sweet, extremely hot in nature.Enter kidney, spleen, the heart, Liver Channel.The pure sun of cinnamic odor, pungent sweet large heat, is apt to away Liver and kidney blood system, mends fire from the gater of life greatly, can warming and recuperating the spleen and kidney yang-energy, boosting source of fire for eliminating abundance of yin, is used for the treatment of insufficiency of kidney-YANG, aversion to cold and cold limbs, frequent urination and enuresis, sexual impotence, and the disease such as hypoactivity of spleen-YANG, coldness and pain in the epigastrium, anorexia and loose stool; Again can warm promoting blood circulation and dispersing cold for relieving pain, be used for the treatment of coldness and pain in the epigastrium, arthralgia due to cold lumbago, all diseases of deficiency and coldness dysmenorrhea; Also can be used for eczema, all diseases of carbuncle of yin nature.Weakness due to chronic disease person, adds a small amount of Cortex Cinnamomi, and QI and blood can be inspired to grow, and lower first void can be made to decline, and the empty sun of floating leads back, i.e. guiding fire to origin.

Stir-baked SQUAMA MANITIS is the scale of Manidae animal Manitis.Effect: detumescence suppuration, scattered silt dredging collateral, stimulate the menstrual flow, stimulating milk secretion, invigorating blood circulation analgesia.Cure mainly: carbuncle skin ulcer is swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, hemostasis, disease crust are gathered.

Cortex Phellodendri and the same use of Cortex Cinnamomi, come from " secret record of the orchid chamber " clearance ball, have another name called Pill for Replenishing the Kidney-yin.Be used for the treatment of heat and accumulate bladder, urine retention is obstructed, little distention and fullness in the abdomen, Urethra astringent pain.Wang Angyun: " Cortex Phellodendri bitter cold is micro-pungent, and it is mutually fiery to rush down bladder, and mend deficiency of kidney-YIN, enter kidney channel blood system, Cortex Cinnamomi is hot, the using corrigent of vacation, and be few cloudy tying-in, cold prescription for pyrosyndrome also.”

Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria are LIUWEI DIHUANG WAN side, and for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen.

In formula, multi-medicament has bactericidal effect and anti-inflammatory effects.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: this Chinese medicine composition is remarkable to the therapeutic effect that prostatitis, urethra scorching hot, urine are smooth etc.This Chinese medicine composition has good antiinflammatory, sterilization and analgesic effect.

Detailed description of the invention

For making the object, technical solutions and advantages of the present invention clearly, below embodiment of the present invention is described further in detail.

Embodiment 1-6 provides the concrete formula for prostatitic tablet, specifically as shown in table 1:

Table 1

Weight (g)	Embodiment 1	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5	Embodiment 6
							Radix Rehmanniae	50	80	60	60	75	65
Cortex Moutan	30	45	42	40	36	31
							Rhizoma Alismatis	55	65	62	60	55	60
Cortex Phellodendri	50	65	55	60	62	52
							The Rhizoma Anemarrhenae	60	80	65	60	70	75
Herba Taraxaci	70	95	80	80	85	75
							The Radix Astragali	75	100	85	80	90	90
Rhizoma Curcumae	50	65	55	60	62	64
							Semen Persicae	35	45	38	40	36	42
Fructus Corni	50	70	65	60	55	60
							Rhizoma Dioscoreae	50	68	60	60	65	65
Poria	50	75	65	60	70	55
							Cortex Cinnamomi	20	30	24	24	25	30
Succinum	15	30	20	24	25	25
							Rhizoma Sparganii	55	80	65	60	70	75
Stir-baked SQUAMA MANITIS	55	65	60	60	55	64

Wherein in above-described embodiment, part Chinese medicine preferably adopts the Chinese medicine after special processing, as stir-baked CORTEX PHELLODENDRI with salt solution replaces Cortex Phellodendri, the stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution replacement Rhizoma Anemarrhenae, stir-baked RHIIZOMA CURCUMAE with vinegar replacement Rhizoma Curcumae, wine Fructus Corni replacement Fructus Corni etc.

Its preparation method is:

(1) decoct: get raw material Radix Rehmanniae, Cortex Moutan, Rhizoma Alismatis, Cortex Phellodendri, the Rhizoma Anemarrhenae, Herba Taraxaci, the Radix Astragali, Rhizoma Curcumae, Semen Persicae and Rhizoma Sparganii by the proportioning of embodiment 4, add the decocting 2 hours of raw material 5 times of weight, filter, the decocting 1 hour of raw material 5 times of weight is added in filtering residue, filter, merge twice filtrate, the decoction liquor after being combined concentrates, and being evaporated to 60 DEG C of relative densities is the thick paste of 1.22.

(2) grind: get Fructus Corni, Rhizoma Dioscoreae, Poria, Squama Manis, Cortex Cinnamomi and succinum by the proportioning of embodiment 4, be ground to 100 object fine powders, mixing obtains powder.

(3) granulate: get thick paste that step (1) obtains and the powder that step (2) obtains by the proportioning of embodiment 4, mixing, obtains tablet through porphyrize, alcohol granulation, drying, tabletted (1000).

One, character analysis

1.1 Poria, Squama Manis, Rhizoma Dioscoreae and Cortex Cinnamomi are analyzed

Get this product, put basis of microscopic observation: irregular branched agglomerate is colourless, meet chloral hydrate liquid and dissolve, hyphae colorless or light brown, diameter 400UM(Poria).Amorphous fragment, closely colourless or faint yellow, there is the similar round that size is indefinite, oval or irregular shape cavity (Squama Manis).Nonglandular hair has 1-4 cell, straight or slightly warpage, and end is even short bifurcated, and wall is level and smooth or have cutin strain line or verruca, and some cells are full of brownish red thing.Needle-like calcium oxalate crystal bundle is present in AC, long 80-240UM(Rhizoma Dioscoreae).Needle-like calcium oxalate crystal is present in ray cell, more tiny, different in size, grows to 43UM, slightly thick or shaft-like (Cortex Cinnamomi) that also have.

1.2 Semen Persicae analyses

Get this product 10, porphyrize, put in conical flask, add a small amount of water and make it moistening, bottle stopper directly hangs a close plug of alkaline trinitrophenol reagent paper, and heat 5 minutes, reagent paper becomes brick-red.

1.3 Cortex Phellodendris are analyzed

Get this product four, porphyrize, add ethanol 10 milliliters, supersound extraction 20 minutes, filter, evaporate to dryness, residue adds 1 milliliter of anhydrous alcohol solution, as need testing solution.Separately get Cortex Phellodendri control medicinal material 0.1 gram, be made in the same way of control medicinal material solution.Get hydrochloric acid little wall alkali reference substance again, add dehydrated alcohol make every 1 milliliter containing the solution of 0.5 milligram, product solution in contrast.According to thin layer chromatography (Chinese Pharmacopoeia version in 2010 annex VI B) test, draw above-mentioned three kinds of each 5ul of solution, put respectively on same silica gel g thin-layer plate, with n-butyl alcohol one glacial acetic acid-water (7:2:1) developing solvent, launch, take out, dry, put ultra-violet lamp (365NM) and inspect.In test sample chromatograph, aobvious identical yellow fluorescence speckle on the position corresponding with control medicinal material chromatograph, an aobvious identical yellow fluorescence speckle on the position corresponding with reference substance chromatograph.

1.4 succinum analyses

Get this product 10, porphyrize, add petroleum ether (60-90 DEG C) 10 milliliters, jolting number minute, filter, get filtrate 5 milliliters and put in test tube, add stratification after 0.5% Schweinfurt green, 5 milliliters of joltings of new preparation, petroleum ether layer must not show green.

Two, antiphlogistic effects analysis

Medicine effect test of the present invention (medicine xylol causes mice ear experiment, the experiment of formaldehyde rat paw edema and the experiment of rat granuloma induced by implantation of cotton pellets)

1.1, animal cleaning grade ICR system mice 40, male female half and half, weight 18-22g, be purchased from Central China University of Science and Technology's Experimental Animal Center.

1.2 xylol of the present invention cause the impact of mice auricle swelling.ICR system mice 40, is divided into 4 groups at random, often organizes 10, male and female half and half.Medication group respectively with low (75mg/kg), in (75mg/kg), high concentration (75mg/kg) gastric infusion, every day 1 time, continuous 7d, after last administration 1h, drip in mouse right ear by dimethylbenzene 0.3mL, left ear is not coated with and contrasts.Put to death by mice cervical dislocation after 2h, lay round auricle at the same position of left and right ear respectively with the card punch of diameter 9mm, weigh, the difference calculating left and right auricle weight, as swelling, compares group difference.Its data are as shown in table 2.

Table 2

Group	Matched group	Low concentration	Middle concentration	High concentration
					Two ears are of poor quality	12.42±3.21	7.53±4.53	6.34±4.19	5.67±4.21

In table 2, tested by medicine of the present invention, 3 concentration group mice auricular concha swellings are all remarkable in matched group, show that medicine xylol of the present invention causes chmice acute ear swelling and has inhibitory action.

Meanwhile, the experiment of formaldehyde rat paw edema and the experiment of rat granuloma induced by implantation of cotton pellets have also been done in this experiment simultaneously, and its experimentation, known by those skilled in the art, specifically causes the impact of mice ear see aforesaid medicine xylol.In the experiment of formaldehyde rat paw edema, when carrageenin local injection brings out rat 1-7 hour sufficient pawl swelling peak, medicine of the present invention 3 concentration group rat foot claw swellings are starkly lower than matched group, show that medicine on Carrageenan local injection of the present invention brings out rat foot claw swelling and has inhibitory action.In the experiment of rat granuloma induced by implantation of cotton pellets, tested by medicine of the present invention, three dosage group granuloma induced by implantation of cotton pellets weigh less than and matched group granuloma weight, significant difference highly significant, can think that this medicine can suppress the formation of cotton balls granulation tissue, have antiinflammatory action to this inflammatory model.

Three, bactericidal effect analysis

Medicine of the present invention is to the bacteriostasis of common bacterial strain, adopt solid process: line on blood ware or common plate so that various test organisms is intensive, punch with 8mm card punch, every hole adds aseptic reagent medicine and is about 0.2mL, 18-24 hour is cultivated at 37 DEG C, observe the size of inhibition zone, for tablet of the present invention, judge that its responsive result is as shown in table 3.

Table 3

Strain	Low concentration	Middle concentration	High concentration
				Gold staphylococcus	+	++	+++
Staphylococcus epidermidis	-	++	++
				Escherichia coli	++	++	+++
Hemolytic streptococcus	+	++	++
				Anaerobe Propionibacterium	++	+++	++

In table: antibacterial circle diameter < 9mm, drug resistance-; Antibacterial circle diameter 9-14mm(does not comprise 14mm), slight sensitive+; Antibacterial circle diameter 14-19mm(does not comprise 19mm), medium sensitivity ++; Antibacterial circle diameter 20-29mm(does not comprise 29mm), extremely sensitive +++.

Cultivate as 67 positive strain interpretations of result from the seminal fluid of patients with chronic bacterial prostatitis, to think in aerobe infection in the highest flight be that golden staphylococcus has 27 strains (40.3%), staphylococcus epidermidis 12 strain (17.9%), escherichia coli 10 strain (14.9%), Hemolytic streptococcus 7 strain (10.4%).Carry out 22A Rapid identification after carrying out anaerobe and aerobe cultivation 24-48h by 300 routine aseptic prostatic fluid samples simultaneously, prove that chronic prostatitis (CP) is aerobic and anaerobe mixed infection.Wherein staphylococcus epidermidis 175 strain (accounting for 58.3%), anaerobe Propionibacterium 88 strain (29.33%), escherichia coli are 30 strains (10%) only.

Chinese medicine composition has certain inhibitory action to causing prostatitic main bacteria seed as can be seen from the above table.

Four, mouse prostate therapeutic effect is analyzed

4.1 carry out acetic acid causes mouse writhing reaction experiment, finds that basic, normal, high three groups are respectively 9.3%, 17.5% and 22.3% to the suppression ratio of the writhing of mice, prove that this medical instrument has certain analgesic effect.

4.2 carry out the effect experiment that Testosterone Propionate causes benign prostatic hyperplasia in rats, and take weight of prostate, voided volume obtain prostate section, after treatment, prostate index is greater than blank group, and voided volume is less than blank group.Visible body of gland lumen of gland normal size under normal group light microscopic, inner cavity surface is smooth, seldom has mamillary raised to intracavity, and epithelial cell marshalling is cube, and interstitial is few.Model group epithelium is that papillary hyperplasia is outstanding in lumen of gland, indentation, and epithelial cell is high column, cladding or false cladding.This medicine low dosage, middle metering group, high dose, QIANLIEKANG matched group all obviously can improve the symptom of model group, body of gland marshalling, epithelial cell not hypertrophy or hypertrophy not obvious, have a small amount of papillae, cell is low column or flat, marshalling.

4.3 effects carrying out hypercholesterolemia model mice prostatic hyperplasia are tested, and take and get weight of prostate, and calculate prostate index, find that prostate index equal significance compared with model group declines.

Five, clinical analysis

5.1 case selection

Case is selected from Hubei Province, time 2011-2013, and number is 150, age 24-50 year, 38 years old mean age.Be divided into QIANLIEKANG matched group 60 people, take embodiment 4 drug study group 90 people, through statistical procedures, no significant difference.Wherein, QIANLIEKANG matched group, every day 3 times, each 4 QIANLIEKANG (Kang Enbei Zhejiang Pharmaceutical Co's production), bfore meals; Experimental group, every day 3 times, each 6, bfore meals.Treatment cycle is one month.

5.2 diagnostic criteria

Tcm diagnosis standard: formulate chronic prostatitis blood stasis with reference to " new Chinese medicine guideline of clinical investigations " (the 3rd volume) and to hold concurrently damp and hot Standards of Chinese Medical Syndrome Differentiation; Western medicine diagnose standard: formulate Western medicine diagnose standard according to " Wu Jieping urology ".

5.3 therapeutic outcome

The change of 5.31 liang of group prostatic fluid routines

A. situation before and after leukocyte treatment, as shown in table 4:

Table 4

Prostatic fluid WBC	QIANLIEKANG matched group	Experimental group
			Multiple normal	21	32
Reduce	33	48
			Constant	3	6
Increase	3	4
			Amount to	60	90

Situation before and after b.CORP treatment, as shown in table 5:

Table 5

Phospholipid body in prostatic fluid	QIANLIEKANG matched group	Experimental group
			In a large number	3	6
Increase	27	41
			Constant	28	40
Reduce	2	3
			Amount to	60	90

After treatment, in experimental group and QIANLIEKANG matched group prostatic fluid, leukocyte obviously reduces, and QIANLIEKANG matched group is slightly better than experimental group; Through treatment after, experimental group and QIANLIEKANG matched group lecithin density have obvious lifting, experimental group and QIANLIEKANG matched group similar.

5.32.NIH-CPSI scoring situation

A. before and after treatment, pain scores compares, as shown in table 6:

Table 6

	Before treatment	After treatment	Amount to
				QIANLIEKANG matched group	13.54±4.17	9.52±2.53	60
Experimental group	13.14±3.91	9.77±2.61	90

B. score value of urinating before and after treatment compares, as shown in table 7:

Table 7

	Before treatment	After treatment	Amount to
				QIANLIEKANG matched group	5.51±2.34	4.15±1.47	60
Experimental group	5.68±2.21	4.19±1.55	90

C. treatment before and after symptom and quality of life score value compare, as shown in table 8:

Table 8

	Before treatment	After treatment	Amount to
				QIANLIEKANG matched group	8.34±2.04	6.19±1.51	60
Experimental group	8.37±2.09	6.25±1.84	90

Experimental group and QIANLIEKANG matched group after the treatment pain scores, urinate score value and quality of life score value all without significant difference, but equal tool significance before and after treatment.

5.33. traditional Chinese medical science individual event symptom compares

A. urine is frequently anxious treats situation, as shown in table 9:

Table 9

	Disappear	Improve	Constant	Amount to
					QIANLIEKANG matched group	13	33	14	60
Experimental group	24	41	25	90

B. urethra scorching hot treatment situation, as shown in table 10:

Table 10

	Disappear	Improve	Constant	Amount to
					QIANLIEKANG matched group	15	42	13	60
Experimental group	24	51	15	90

C. dribble of urine treats situation not to the utmost, as shown in table 11:

Table 11

	Disappear	Improve	Constant	Amount to
					QIANLIEKANG matched group	9	30	21	60
Experimental group	18	43	29	90

D. testicular pain treatment situation, as shown in table 12:

Table 12

	Disappear	Improve	Constant	Amount to
					QIANLIEKANG matched group	25	27	8	60
Experimental group	40	40	10	90

E. drip after urine and treat situation in vain, as shown in table 13:

Table 13

	Disappear	Improve	Constant	Amount to
					QIANLIEKANG matched group	19	10	31	60
Experimental group	29	17	44	90

Urgency, urethra scorching hot, dribble of urine are not to the utmost frequently, testicular pain and urine drips the equal no significant difference of white therapeutic effect afterwards, and all have certain effect to the cardinal symptom urine of patient for experimental group and QIANLIEKANG matched group.

5.34 therapeutic effect compares

A. efficacy assessment standard: this standard is formulated with reference to " guideline of clinical investigations of new Chinese medicine treatment chronic prostatitis (non-specific) ".

Effective, for clinical symptoms integration reduces >=60%, prostate tenderness and quality all have clear improvement, and EPS checks that continuous more than 2 times numeration of leukocyte comparatively treat front minimizing >=60%.

Effectively, for clinical symptoms integration reduces >=30%, prostate tenderness and quality are all improved, and EPS checks that continuous more than 2 times numeration of leukocyte comparatively treat front minimizing >=30%.

Invalid, for clinical symptoms integration reduces < 30% or unchanged, prostate tenderness and quality are all without improvement, and EPS checks that continuous more than 2 times numeration of leukocyte reduce < 30% or unchanged before comparatively treating.

B. therapeutic outcome: after using a course for the treatment of, experimental group: effective 39 examples, account for 43.4%; Effective 31 examples, account for 34.4%; Invalid 20 examples, account for 22.2%; Total effective rate 77.8%.QIANLIEKANG matched group: effective 27 examples, account for 45%; Effective 21 examples, account for 35%; Invalid 20 examples, account for 20%; Total effective rate 80%.Therapeutic outcome is as shown in table 14.

Table 14

	Amount to	Effective	Effectively	Invalid	Total effective rate
						QIANLIEKANG matched group	60	27	21	12	80%
Experimental group	90	39	31	20	77.8%

The therapeutic effect of experimental group is slightly worse than QIANLIEKANG matched group as can be seen from the above table, but is more or less the same, and this traditional Chinese medicine composition for treating effect is all right, but the source of raw material is more extensive and cheap.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. one kind is used for the treatment of prostatitic Chinese medicine composition, it is characterized in that, its composition with parts by weight is: Radix Rehmanniae 50-80 part, Cortex Moutan 30-45 part, Rhizoma Alismatis 55-65 part, Cortex Phellodendri 50-65 part, Rhizoma Anemarrhenae 60-80 part, Herba Taraxaci 70-95 part, Radix Astragali 75-100 part, Rhizoma Curcumae 50-65 part, Semen Persicae 35-45 part, Fructus Corni 50-70 part, Rhizoma Dioscoreae 50-68 part, Poria 50-75 part, Cortex Cinnamomi 20-30 part, succinum 15-30 part, Rhizoma Sparganii 55-80 part, stir-baked SQUAMA MANITIS 55-65 part.

2. be according to claim 1ly used for the treatment of prostatitic Chinese medicine composition, it is characterized in that, its composition with parts by weight is: Radix Rehmanniae 60 parts, Cortex Moutan 40 parts, Rhizoma Alismatis 60 parts, Cortex Phellodendri 60 parts, the Rhizoma Anemarrhenae 60 parts, Herba Taraxaci 80 parts, the Radix Astragali 80 parts, Rhizoma Curcumae 60 parts, 40 parts, Semen Persicae, Fructus Corni 60 parts, Rhizoma Dioscoreae 60 parts, 60 parts, Poria, Cortex Cinnamomi 24 parts, succinum 24 parts, Rhizoma Sparganii 60 parts, stir-baked SQUAMA MANITIS 60 parts.

3. be according to claim 1ly used for the treatment of prostatitic Chinese medicine composition, it is characterized in that, its composition with parts by weight is: Radix Rehmanniae 50-80 part, Cortex Moutan 30-45 part, Rhizoma Alismatis 55-65 part, stir-baked CORTEX PHELLODENDRI with salt solution 50-65 part, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 60-80 part, Herba Taraxaci 70-95 part, Radix Astragali 75-100 part, stir-baked RHIIZOMA CURCUMAE with vinegar 50-65 part, Semen Persicae 35-45 part, wine Fructus Corni 50-70 part, Rhizoma Dioscoreae 50-68 part, Poria 50-75 part, Cortex Cinnamomi 20-30 part, succinum 15-30 part, stir-baked RHIZOMA SPARGANII with vinegar 55-80 part, stir-baked SQUAMA MANITIS 55-65 part.

4. be according to claim 3ly used for the treatment of prostatitic Chinese medicine composition, it is characterized in that, its composition with parts by weight is: Radix Rehmanniae 60 parts, Cortex Moutan 40 parts, Rhizoma Alismatis 60 parts, stir-baked CORTEX PHELLODENDRI with salt solution 60 parts, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 60 parts, Herba Taraxaci 80 parts, the Radix Astragali 80 parts, stir-baked RHIIZOMA CURCUMAE with vinegar 60 parts, 40 parts, Semen Persicae, wine Fructus Corni 60 parts, Rhizoma Dioscoreae 60 parts, 60 parts, Poria, Cortex Cinnamomi 24 parts, succinum 24 parts, stir-baked RHIZOMA SPARGANII with vinegar 60 parts, stir-baked SQUAMA MANITIS 60 parts.

5. according to any one of claim 1-4, be used for the treatment of prostatitic Chinese medicine composition, it is characterized in that, described Chinese medicine composition is tablet.

6. a compositions, is characterized in that, is used for the treatment of prostatitic Chinese medicine composition and pharmaceutical carrier described in any one of the claim 1-4 containing effective dose.

7. compositions according to claim 6, is characterized in that, its preparation method comprises:

(1) decoct: get raw material Radix Rehmanniae, Cortex Moutan, Rhizoma Alismatis, Cortex Phellodendri, the Rhizoma Anemarrhenae, Herba Taraxaci, the Radix Astragali, Rhizoma Curcumae, Semen Persicae and Rhizoma Sparganii by proportioning, add the decocting 1.5-2.5 hour of raw material 4-6 times weight, filter, the decocting 0.5-1.5 hour of raw material 4-6 times weight is added in filtering residue, merge twice decoction liquor, decoction liquor after being combined concentrates, and is evaporated to the thick paste that 60 DEG C of relative densities are 1.20-1.25;

(2) grind: get Fructus Corni, Rhizoma Dioscoreae, Poria, Squama Manis, Cortex Cinnamomi and succinum by proportioning, be ground to 80-200 object fine powder, mixing obtains powder;

(3) granulate: get thick paste that step (1) obtains and the powder that step (2) obtains by proportioning, mixing, obtains tablet through porphyrize, alcohol granulation, drying, tabletted.