CN102641446A - Chinese medicament for treating prostatic diseases and preparation method thereof - Google Patents
Chinese medicament for treating prostatic diseases and preparation method thereof Download PDFInfo
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- CN102641446A CN102641446A CN2012101074215A CN201210107421A CN102641446A CN 102641446 A CN102641446 A CN 102641446A CN 2012101074215 A CN2012101074215 A CN 2012101074215A CN 201210107421 A CN201210107421 A CN 201210107421A CN 102641446 A CN102641446 A CN 102641446A
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Abstract
The invention relates to a Chinese medicament for treating prostatic diseases and a preparation method thereof. The Chinese medicament comprises the following components: 9 to 12 grams of prepared rehmannia root, 9 to 12 grams of coix seed, 6 to 9 grams of Chinese wax gourd seed, 5 to 8 grams of dogwood, 5 to 8 grams of Chinese yam, 5 to 8 grams of peony bark, 5 to 8 grams of atractylodes, 5 to 8 grams of peach kernel, 4 to 7 grams of alismatis rhizome, 4 to 7 grams of tuckahoe, 1 to 5 grams of cassia twig, 1 to 5 grams of monkshood, 1 to 5 grams of leek seed, 1 to 4 grams of epimedium and 1 to 5 grams of liquorice. The Chinese medicament for treating the prostatic diseases has the functions of strengthening and consolidating body resistance, nourishing yin and tonifying kidney, promoting blood circulation to remove blood stasis, clearing heat and promoting diuresis, tonifying yang and controlling nocturnal emission, inducing diuresis, warming and invigorating kidney yang, tonifying kidney yin, regulating abnormally exuberant or abnormally debilitated kidney qi and the like, and can be used for treating the prostatic diseases such as stranguria, frequent micturition, urgent urination, endless urine drop, chronic prostatitis and prostatic hyperplasia caused by kidney deficiency.
Description
Technical field
The present invention relates to a kind of Chinese medicine that is used to treat prostatosis and preparation method thereof.
Background technology
Prostatosis is a kind of common disease, and this disease singly is not that body of prostate itself has disease, and disease also takes place urinary system such as bladder and urethra, and the pelvic cavity position, and perineum part etc. all have distending pain, and the obstacle that also has sexual function.Present Therapeutic Method mainly is to be main with naturopathy; The expensive effect is not again fine; Also having the Chinese patent medicine of treating prostatosis now also is that prescription is single, makes up a prescription composition very little, can not treat the disease that various organs produce simultaneously; Even cured the inflammation of prostate itself, and other prostatitic syndrome can not be treated.
Summary of the invention
The present invention is directed to the above-mentioned deficiency that existing prostatosis exists in treatment, a kind of Chinese medicine that is used to treat prostatosis and preparation method thereof is provided.
The technical scheme that the present invention solves the problems of the technologies described above is following: a kind of each component and content that is used to treat the Chinese medicine of prostatosis comprises: Radix Rehmanniae Preparata 9～12g, Semen Coicis 9～12g, Semen Benincasae 6～9g, Fructus Corni 5～8g, Rhizoma Dioscoreae 5～8g, Cortex Moutan 5～8g, Rhizoma Atractylodis 5～8g, Semen Persicae 5～8g, Rhizoma Alismatis 4～7g, Poria 4～7g, Ramulus Cinnamomi 1～5g, Radix Aconiti Lateralis Preparata 1～5g, Semen Allii Tuberosi 1～5g, Herba Epimedii 1～4g and Radix Glycyrrhizae 1～5g.
On the basis of technique scheme, the present invention can also do following improvement.
Further, also comprise Herba Taraxaci 5～8 and Radix Scutellariae 3～5g.
Adopt the beneficial effect of such scheme to be:, after dysuric patient adds Herba Taraxaci and Radix Scutellariae, can increase its clearing away heat-damp and promoting diuresis, the effect of inducing diuresis for treating stranguria syndrome to some sxs.
Further, the said Chinese medicine that is used to treat prostatosis is water-honeyed pill, concentrated pill, granule or capsule.
The present invention also provides a kind of technical scheme that solves the problems of the technologies described above following: a kind of preparation method of Chinese medicine that is used to treat prostatosis may further comprise the steps: at first, the described Cortex Moutan of claim 1, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into fine powder; Then; The described Radix Rehmanniae Preparata of claim 1, Semen Coicis, Semen Benincasae, Fructus Corni, Semen Persicae, Rhizoma Alismatis, Poria, Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata, Semen Allii Tuberosi, Herba Epimedii, these 12 kinds of components of Radix Glycyrrhizae are added the water that accounts for 10 times of amounts of this 12 kinds of composition weight and decoct three times; Wherein, 1.5 hours for the first time, each each 1 hour of second, third time; At last, the medicinal liquid that at every turn decocted is filtered, remerge filtrating, the filtrate decompression after merging is concentrated into relative density be 1.35～1.37 thick paste of (50 ℃ time record), add the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into again, mixing gets final product.
It is each 6 to 12g that the patient takes method that the present invention is used to treat the Chinese medicine of prostatosis, 3 times on the one.
Further, when said Chinese medicinal components also comprises Herba Taraxaci 5～8 with Radix Scutellariae 3～5g, Herba Taraxaci and Radix Scutellariae while are added water with said 12 kinds of components decoct.
The invention has the beneficial effects as follows: the Chinese medicine that the present invention is used to treat prostatosis has strengthening the body resistance, nourishing YIN for benefiting the kidney, blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis, tonifying YANG controlling nocturnal emission with astringent drugs, diuresis; Warming and recuperating the kidney-YANG; The tonifying kidney-yin of holding concurrently can adjust that kidney qi is contained partially or function such as decline partially, can be used for treating that stranguria, disease due to suffering from a deficiency of the kidney seen frequent micturition, urgent micturition, the sound of rain pattering of urinating not to the utmost, prostatosis such as chronic prostatitis, hyperplasia of prostate larynx person.
The specific embodiment
Below principle of the present invention and characteristic are described, institute gives an actual example and only is used to explain the present invention, is not to be used to limit scope of the present invention.
Embodiment one
In the present embodiment, Rhizoma Dioscoreae 5～8g, Cortex Moutan 5～8g, Rhizoma Atractylodis 5～8g are ground into fine powder; Then; With Radix Rehmanniae Preparata 9～12g, Semen Coicis 9～12g, Semen Benincasae 6～9g, Fructus Corni 5～8g,, Semen Persicae 5～8g, Rhizoma Alismatis 4～7g, Poria 4～7g, Ramulus Cinnamomi 1～5g, Radix Aconiti Lateralis Preparata 1～5g, Semen Allii Tuberosi 1～5g, Herba Epimedii 1～4g and these 12 kinds of components of Radix Glycyrrhizae 1～5g add the water that accounts for 10 times of amounts of this 12 kinds of composition weight and decoct three times; Wherein, 1.5 hours for the first time, each each 1 hour of second, third time; At last, the medicinal liquid that at every turn decocted is filtered, remerge filtrating, the filtrate decompression after merging is concentrated into relative density be 1.35～1.37 thick paste of (50 ℃ time record), add the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into again, mixing gets final product.
It is its trimestral clinical observation that the patient who faces 25 routine hyperplasia of prostates has down carried out, and reports as follows:
Clinical data: this group has 25 examples, and the age is 50～79 years old, 65 years old mean age.Medical history is 8 years to 10 years, and all patients all have frequent micturition, dysuria symptom in various degree.Prostate volume 20～25ml wherein, 2 examples; 25～50ml, 18 examples;＞50ml, 5 examples.5 routine patient's bladder residual urine＞50ml are arranged.All patients do not have the acute urinary retention medical history, complication such as no vesical calculus, urinary system infection and hydronephrosis.All patients wait special treatment without crossing operation, do not take the medicine of other treatment prostatic hyperplasia in two weeks.
Instructions of taking: oral, every day 3 times, each 6 grams, three totally months.
Observation index: after taking medicine preceding and taking medicine three months, observe patient's subjective and objective index, period in a medicine notes observing untoward reaction.International prostate gland symptoms scoring (IPSS) and quality of life scoring (QOL) are adopted in the evaluation of subjective symptom.Objective indicator comprises Qmax (Qmax), prostate volume and residual urine volume.Qmax adopts urine flow rate appearance to measure, and prostate volume adopts through the abdomen B ultrasonic with residual urine volume and measures, prostate volume (ml)=0.52 * up and down footpath * anteroposterior diameter * about directly.Blood, routine urinalysis, hepatic and renal function inspection are done in the subjective untoward reaction of record patient during the treatment before and after the treatment.
The result: the variation of 25 routine patients' IPSS, QOL and Qmax after taking medicine three months, see table 1.
The variation of MAIN OUTCOME MEASURES before and after table 1 treatment
Can find out that by table 1 patient's subjective and objective index all is significantly improved after treatment in three months, the improvement of subjective index is more obvious than the improvement of objective indicator.The take medicine patient of preceding residual urine volume＞50ml of 5 examples, the average residual urine volume in the back of taking medicine reduces to 38ml by 69ml.In all patients untoward reaction not taking place, takes medicine to patient's blood, the not influence of routine urinalysis volume hepatic and renal function.
Embodiment two
In the present embodiment, Rhizoma Dioscoreae 5～8g, Cortex Moutan 5～8g, Rhizoma Atractylodis 5～8g are ground into fine powder; Then; With Radix Rehmanniae Preparata 9～12g, Semen Coicis 9～12g, Semen Benincasae 6～9g, Fructus Corni 5～8g,, Semen Persicae 5～8g, Rhizoma Alismatis 4～7g, Poria 4～7g, Ramulus Cinnamomi 1～5g, Radix Aconiti Lateralis Preparata 1～5g, Semen Allii Tuberosi 1～5g, Herba Epimedii 1～4g, Radix Glycyrrhizae 1～5g, Herba Taraxaci 5～8 and these 12 kinds of components of Radix Scutellariae 3～5g add the water that accounts for 10 times of amounts of this 12 kinds of composition weight and decoct three times; Wherein, 1.5 hours for the first time, each each 1 hour of second, third time; At last, the medicinal liquid that at every turn decocted is filtered, remerge filtrating, the filtrate decompression after merging is concentrated into relative density be 1.35～1.37 thick paste of (50 ℃ time record), add the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into again, mixing gets final product.
Patient in the face of 15 routine chronic prostatitiss has carried out being individual month clinical observation of one of which down, reports as follows:
Clinical data: this group has 15 examples, 22～52 years old age, the course of disease 2 months to 8 years.Prostatic fluid microscopy: WBC＞10/HP five examples before wherein taking medicine, (ten examples of WBC＜10/HP) are not all done the prostatic fluid antibacterial culturing to the normal person of prostatic fluid.The preceding prostate ultrasound diagnosis of taking medicine of eight examples: two routine echoes are inhomogeneous, and all the other six examples are normal.
Method of administration: oral three times of every day, each 6g took medicine one month continuously.
Criterion of therapeutical effect: 1. produce effects: clinical symptom disappearance, prostatic fluid microscopy WBC＜10/HP.2. effective: clinical symptoms obviously alleviates or prostatic fluid microscopy WBC obviously reduces.3. invalid: symptom and prostatic fluid microscopy do not have improvement.
Clinical effectiveness: see all kinds of symptom curative effects of table 2 and the total effects of table 3.
All kinds of symptom curative effects of table 2
Table 3 total effects
| Total routine number | Produce effects | Effectively | Invalid |
| 15 | 4 | 9 | 2 |
Efficacy analysis:
1. observe 15 routine patients altogether, obtain produce effects person's 4 examples, effective 9 examples, invalid 2 examples, total effective rate is 86.6%.
2. to frequent micturition (7/9), urine retention (10/12), lumbosacral pain (8/9), lower abdominal pain (7/7), can pain over the perineum (5/6) and fear of cold doing well,improvings such as (9/10) obvious.
3. be that insufficiency of kidney-YANG person effect is good especially to Chinese medical discrimination, course of disease shorter one curative effect is superior to course of disease elder.
4.15 routine patient is evident in efficacy, does not see untoward reaction.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. Chinese medicine that is used to treat prostatosis; It is characterized in that its each component and content comprise: Radix Rehmanniae Preparata 9～12g, Semen Coicis 9～12g, Semen Benincasae 6～9g, Fructus Corni 5～8g, Rhizoma Dioscoreae 5～8g, Cortex Moutan 5～8g, Rhizoma Atractylodis 5～8g, Semen Persicae 5～8g, Rhizoma Alismatis 4～7g, Poria 4～7g, Ramulus Cinnamomi 1～5g, Radix Aconiti Lateralis Preparata 1～5g, Semen Allii Tuberosi 1～5g, Herba Epimedii 1～4g and Radix Glycyrrhizae 1～5g.
2. the Chinese medicine that is used to treat prostatosis according to claim 1 is characterized in that, also comprises Herba Taraxaci 5～8 and Radix Scutellariae 3～5g.
3. the Chinese medicine that is used to treat prostatosis according to claim 1 is characterized in that, the said Chinese medicine that is used to treat prostatosis is water-honeyed pill, concentrated pill, granule or capsule.
4. a preparation method of Chinese medicine that is used to treat prostatosis is characterized in that, this method for preparing may further comprise the steps: at first, the described Cortex Moutan of claim 1, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into fine powder; Then; The described Radix Rehmanniae Preparata of claim 1, Semen Coicis, Semen Benincasae, Fructus Corni, Semen Persicae, Rhizoma Alismatis, Poria, Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata, Semen Allii Tuberosi, Herba Epimedii, these 12 kinds of components of Radix Glycyrrhizae are added the water that accounts for 10 times of amounts of this 12 kinds of composition weight and decoct three times; Wherein, 1.5 hours for the first time, each each 1 hour of second, third time; At last, the medicinal liquid that at every turn decocted is filtered, remerge filtrating, it is 1.35～1.37 thick paste that the filtrate decompression after merging is concentrated into relative density, adds the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into again, and mixing gets final product.
5. the preparation method of Chinese medicine that is used to treat prostatosis according to claim 4 is characterized in that, when said Chinese medicinal components also comprises Herba Taraxaci 5～8 with Radix Scutellariae 3～5g, Herba Taraxaci and Radix Scutellariae while is added water with said 12 kinds of components decoct.
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| CN201210107421.5A CN102641446B (en) | 2012-04-12 | 2012-04-12 | Chinese medicament for treating prostatic diseases and preparation method thereof |
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| CN201210107421.5A CN102641446B (en) | 2012-04-12 | 2012-04-12 | Chinese medicament for treating prostatic diseases and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104043010A (en) * | 2014-06-25 | 2014-09-17 | 姜丽莎 | Traditional Chinese medicine (TCM) composition for treating prostatitis |
| CN104547922A (en) * | 2015-01-05 | 2015-04-29 | 罗田县万密斋医院 | Chinese medicinal composition for treating prostatitis and preparation method thereof |
-
2012
- 2012-04-12 CN CN201210107421.5A patent/CN102641446B/en active Active
Non-Patent Citations (4)
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| 孙冻梅: "高效液相色谱法测定前列舒丸中马钱苷含量", 《中国药业》 * |
| 戴岳等: "黄芩总苷对大鼠急慢性前列腺炎影响的实验研究", 《中医药学刊》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104043010A (en) * | 2014-06-25 | 2014-09-17 | 姜丽莎 | Traditional Chinese medicine (TCM) composition for treating prostatitis |
| CN104547922A (en) * | 2015-01-05 | 2015-04-29 | 罗田县万密斋医院 | Chinese medicinal composition for treating prostatitis and preparation method thereof |
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| CN102641446B (en) | 2015-04-22 |
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Address after: 100097 3F, block B, Jinyuan times business center, lantianchang East Road, Haidian District, Beijing Patentee after: Beijing kangdini Pharmaceutical Co.,Ltd. Address before: 100097 3F, block B, Jinyuan times business center, lantianchang East Road, Haidian District, Beijing Patentee before: BEIJING CONTINENT PHARMACEUTICAL Co.,Ltd. |
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