CN102641446B - Chinese medicament for treating prostatic diseases and preparation method thereof - Google Patents
Chinese medicament for treating prostatic diseases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicament for treating prostatic diseases and a preparation method thereof. The Chinese medicament comprises the following components: 9 to 12 grams of prepared rehmannia root, 9 to 12 grams of coix seed, 6 to 9 grams of Chinese wax gourd seed, 5 to 8 grams of dogwood, 5 to 8 grams of Chinese yam, 5 to 8 grams of peony bark, 5 to 8 grams of atractylodes, 5 to 8 grams of peach kernel, 4 to 7 grams of alismatis rhizome, 4 to 7 grams of tuckahoe, 1 to 5 grams of cassia twig, 1 to 5 grams of monkshood, 1 to 5 grams of leek seed, 1 to 4 grams of epimedium and 1 to 5 grams of liquorice. The Chinese medicament for treating the prostatic diseases has the functions of strengthening and consolidating body resistance, nourishing yin and tonifying kidney, promoting blood circulation to remove blood stasis, clearing heat and promoting diuresis, tonifying yang and controlling nocturnal emission, inducing diuresis, warming and invigorating kidney yang, tonifying kidney yin, regulating abnormally exuberant or abnormally debilitated kidney qi and the like, and can be used for treating the prostatic diseases such as stranguria, frequent micturition, urgent urination, endless urine drop, chronic prostatitis and prostatic hyperplasia caused by kidney deficiency.
Description
Technical field
The present invention relates to a kind of Chinese medicine being used for the treatment of prostatosis and preparation method thereof.
Background technology
Prostatosis is a kind of common disease, and this disease is not singly that body of prostate itself has disease, and urinary system such as bladder and urethra also disease occur, and pelvic cavity position, and perineum part etc. have distending pain, and also has the obstacle of sexual function.Current Therapeutic Method is mainly based on naturopathy, price effect is not again fine, the Chinese patent medicine also having treatment prostatosis now is also that formula is single, make up a prescription composition very little, the disease that various organ produces can not be treated simultaneously, even if cured the inflammation of prostate itself, and other prostatitic syndrome can not be treated.
Summary of the invention
The present invention is directed to existing prostatosis above shortcomings in treatment, a kind of Chinese medicine being used for the treatment of prostatosis and preparation method thereof is provided.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of be used for the treatment of the Chinese medicine of prostatosis each component and content comprise: Radix Rehmanniae Preparata 9 ~ 12g, Semen Coicis 9 ~ 12g, Semen Benincasae 6 ~ 9g, Fructus Corni 5 ~ 8g, Rhizoma Dioscoreae 5 ~ 8g, Cortex Moutan 5 ~ 8g, Rhizoma Atractylodis 5 ~ 8g, Semen Persicae 5 ~ 8g, Rhizoma Alismatis 4 ~ 7g, Poria 4 ~ 7g, Ramulus Cinnamomi 1 ~ 5g, Radix Aconiti Lateralis Preparata 1 ~ 5g, Semen Allii Tuberosi 1 ~ 5g, Herba Epimedii 1 ~ 4g and Radix Glycyrrhizae 1 ~ 5g.
On the basis of technique scheme, the present invention can also do following improvement.
Further, Herba Taraxaci 5 ~ 8 and Radix Scutellariae 3 ~ 5g is also comprised.
The beneficial effect of employing such scheme is: to some exacerbation of symptoms, after dysuric patient adds Herba Taraxaci and Radix Scutellariae, can increase its clearing away heat-damp and promoting diuresis, the effect of inducing diuresis for treating stranguria syndrome.
Further, the Chinese medicine being used for the treatment of prostatosis described in is water-honeyed pill, concentrated pill, granule or capsule.
The present invention also provides a kind of technical scheme solved the problems of the technologies described above as follows: a kind of preparation method being used for the treatment of the Chinese medicine of prostatosis comprises the following steps: first, and Cortex Moutan according to claim 1, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into fine powder; Then, Radix Rehmanniae Preparata according to claim 1, Semen Coicis, Semen Benincasae, Fructus Corni, Semen Persicae, Rhizoma Alismatis, Poria, Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata, Semen Allii Tuberosi, Herba Epimedii, these 12 kinds of components of Radix Glycyrrhizae are added the water accounting for these 12 kinds of composition weight 10 times amount and carry out decoction three times, wherein, 1.5 hours first times, second, third time each each 1 hour; Finally, being filtered by the medicinal liquid at every turn decocted, remerge filtrate, is the thick paste of 1.35 ~ 1.37 (recording when 50 DEG C) by filtrate reduced in volume to the relative density after merging, add the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into again, mix.
It is each 6 to 12g that patient takes the method that the present invention is used for the treatment of the Chinese medicine of prostatosis, 3 times on the one.
Further, when described Chinese medicinal components also comprises Herba Taraxaci 5 ~ 8 and Radix Scutellariae 3 ~ 5g, Herba Taraxaci and Radix Scutellariae are added water with described 12 kinds of components simultaneously and decocts.
The invention has the beneficial effects as follows: the Chinese medicine that the present invention is used for the treatment of prostatosis has strengthening the body resistance, nourishing YIN for benefiting the kidney, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, tonifying YANG controlling nocturnal emission with astringent drugs, diuresis, warming and recuperating the kidney-YANG, hold concurrently tonifying kidney-yin, adjustable kidney qi is contained or the function such as partially to decline partially, can be used for treating suffer from a deficiency of the kidney that caused stranguria, disease see frequent micturition, urgent micturition, the sound of rain pattering of urinating not to the utmost, chronic prostatitis, the prostatosis such as hyperplasia of prostate larynx person.
Detailed description of the invention
Be described principle of the present invention and feature below, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment one
In the present embodiment, Rhizoma Dioscoreae 5 ~ 8g, Cortex Moutan 5 ~ 8g, Rhizoma Atractylodis 5 ~ 8g are ground into fine powder; Then, by Radix Rehmanniae Preparata 9 ~ 12g, Semen Coicis 9 ~ 12g, Semen Benincasae 6 ~ 9g, Fructus Corni 5 ~ 8g, these 12 kinds of components of Semen Persicae 5 ~ 8g, Rhizoma Alismatis 4 ~ 7g, Poria 4 ~ 7g, Ramulus Cinnamomi 1 ~ 5g, Radix Aconiti Lateralis Preparata 1 ~ 5g, Semen Allii Tuberosi 1 ~ 5g, Herba Epimedii 1 ~ 4g and Radix Glycyrrhizae 1 ~ 5g add the water accounting for these 12 kinds of composition weight 10 times amount and carry out decoction three times, wherein, 1.5 hours first times, second, third time each each 1 hour; Finally, being filtered by the medicinal liquid at every turn decocted, remerge filtrate, is the thick paste of 1.35 ~ 1.37 (recording when 50 DEG C) by filtrate reduced in volume to the relative density after merging, add the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into again, mix.
Carry out, for its trimestral clinical observation, being reported as follows to the patient of 25 routine hyperplasia of prostates below:
Clinical data: this group has 25 examples, and the age is 50 ~ 79 years old, 65 years old mean age.Medical history is 8 years to 10 years, and all patients all have frequent micturition, dysuria symptom in various degree.Wherein prostate volume 20 ~ 25ml, 2 examples; 25 ~ 50ml, 18 examples; > 50ml, 5 examples.There are 5 routine patient's bladder residual urine > 50ml.All patients without acute urinary retention medical history, without complication such as vesical calculus, urinary system infection and hydronephrosis.All patients, without special treatments such as operations, did not take the medicine of other treatment prostatic hyperplasia in two weeks.
Instructions of taking: oral, every day 3 times, each 6 grams, three totally months.
Observation index: before taking medicine and after taking medicine three months, observes the subjective and objective index of patient, and period in a medicine is noted observing untoward reaction.The evaluation of subjective symptom adopts international contest (IPSS) and life quality scores (QOL).Objective indicator comprises Qmax (Qmax), prostate volume and residual urine volume.Qmax adopts urinary flow instrument to measure, and prostate volume and residual urine volume adopt and measure through abdomen B ultrasonic, prostate volume (ml)=0.52 × footpath × anteroposterior diameter × footpath, left and right up and down.The subjective untoward reaction of treatments period record patient, does blood, routine urinalysis, hepatic and renal function inspection before and after treatment.
Result: the change of IPSS, QOL and Qmax of 25 routine patients after taking medicine three months, in table 1.
The change of front and back MAIN OUTCOME MEASURES treated by table 1
As can be seen from Table 1 after treatment in three months, the subjective and objective index of patient is all significantly improved, and the improvement of subjective index is more obvious compared with the improvement of objective indicator.5 examples take medicine before the patient of residual urine volume > 50ml, after taking medicine, average residual urine volume reduces to 38ml by 69ml.In all patients, untoward reaction does not occur, taking medicine does not affect the blood of patient, routine urinalysis volume hepatic and renal function.
Embodiment two
In the present embodiment, Rhizoma Dioscoreae 5 ~ 8g, Cortex Moutan 5 ~ 8g, Rhizoma Atractylodis 5 ~ 8g are ground into fine powder; Then, by Radix Rehmanniae Preparata 9 ~ 12g, Semen Coicis 9 ~ 12g, Semen Benincasae 6 ~ 9g, Fructus Corni 5 ~ 8g, these 12 kinds of components of Semen Persicae 5 ~ 8g, Rhizoma Alismatis 4 ~ 7g, Poria 4 ~ 7g, Ramulus Cinnamomi 1 ~ 5g, Radix Aconiti Lateralis Preparata 1 ~ 5g, Semen Allii Tuberosi 1 ~ 5g, Herba Epimedii 1 ~ 4g, Radix Glycyrrhizae 1 ~ 5g, Herba Taraxaci 5 ~ 8 and Radix Scutellariae 3 ~ 5g add the water accounting for these 12 kinds of composition weight 10 times amount and carry out decoction three times, wherein, 1.5 hours first times, second, third time each each 1 hour; Finally, being filtered by the medicinal liquid at every turn decocted, remerge filtrate, is the thick paste of 1.35 ~ 1.37 (recording when 50 DEG C) by filtrate reduced in volume to the relative density after merging, add the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into again, mix.
Carry out, for the one clinical observation of individual month, being reported as follows to the patient of 15 routine chronic prostatitiss below:
Clinical data: this group has 15 examples, 22 ~ 52 years old age, the course of disease 2 months to 8 years.Prostatic fluid microscopy before wherein taking medicine: WBC > 10/HP five example, the normal person of prostatic fluid (WBC < 10/HP) ten example, does not all do prostatic fluid antibacterial culturing.Eight examples take medicine before prostate ultrasound diagnosis: two routine Echo heterogenicities are even, and all the other six examples are normal.
Method of administration: oral three times of every day, each 6g, takes medicine one month continuously.
Criterion of therapeutical effect: 1. effective: clinical symptom disappearance, prostatic fluid microscopy WBC < 10/HP.2. effective: clinical symptoms obviously alleviates or prostatic fluid microscopy WBC obviously reduces.3. invalid: symptom and prostatic fluid microscopy are without improvement.
Clinical effectiveness: in all kinds of symptom curative effect of table 2 and the total effects of table 3.
All kinds of symptom curative effect of table 2
Table 3 total effects
| Total number of cases | Effective | Effectively | Invalid |
| 15 | 4 | 9 | 2 |
Efficacy analysis:
1. observe 15 routine patients altogether, obtain effective person 4 example, effective 9 examples, invalid 2 examples, total effective rate is 86.6%.
2. pair frequent micturition (7/9), urine retention (10/12), lumbosacral pain (8/9), lower abdominal pain (7/7), the symptoms such as perineal pain (5/6) and fear of cold (9/10) are improved obviously.
3. pair Chinese medical discrimination is that insufficiency of kidney-YANG person effect is especially good, is better than course of disease elder to course of disease shorter one curative effect.
4.15 routine patients are evident in efficacy, have no untoward reaction.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. one kind is used for the treatment of the Chinese medicine of prostatosis, it is characterized in that, the raw material of its Chinese medicine consists of: Radix Rehmanniae Preparata 9 ~ 12g, Semen Coicis 9 ~ 12g, Semen Benincasae 6 ~ 9g, Fructus Corni 5 ~ 8g, Rhizoma Dioscoreae 5 ~ 8g, Cortex Moutan 5 ~ 8g, Rhizoma Atractylodis 5 ~ 8g, Semen Persicae 5 ~ 8g, Rhizoma Alismatis 4 ~ 7g, Poria 4 ~ 7g, Ramulus Cinnamomi 1 ~ 5g, Radix Aconiti Lateralis Preparata 1 ~ 5g, Semen Allii Tuberosi 1 ~ 5g, Herba Epimedii 1 ~ 4g, Radix Glycyrrhizae 1 ~ 5g, Herba Taraxaci 5 ~ 8 and Radix Scutellariae 3 ~ 5g.
2. be used for the treatment of a preparation method for the Chinese medicine of prostatosis, it is characterized in that, this preparation method comprises the following steps: first, and Cortex Moutan according to claim 1, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into fine powder; Then, Radix Rehmanniae Preparata according to claim 1, Semen Coicis, Semen Benincasae, Fructus Corni, Semen Persicae, Rhizoma Alismatis, Poria, Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata, Semen Allii Tuberosi, Herba Epimedii, these 12 kinds of components of Radix Glycyrrhizae are added in the water accounting for these 12 kinds of composition weight 10 times amount, add Herba Taraxaci according to claim 1 and Radix Scutellariae simultaneously, carry out decoction three times, wherein, 1.5 hours first times, second, third time each each 1 hour; Finally, being filtered by the medicinal liquid at every turn decocted, remerge filtrate, is the thick paste of 1.35 ~ 1.37 by the filtrate reduced in volume after merging to relative density, then adds the fine powder that Cortex Moutan, Rhizoma Dioscoreae and Rhizoma Atractylodis are ground into, and mixes.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104043010A (en) * | 2014-06-25 | 2014-09-17 | 姜丽莎 | Traditional Chinese medicine (TCM) composition for treating prostatitis |
| CN104547922A (en) * | 2015-01-05 | 2015-04-29 | 罗田县万密斋医院 | Chinese medicinal composition for treating prostatitis and preparation method thereof |
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Non-Patent Citations (4)
| Title |
|---|
| 蒲公英方治疗慢性前列腺炎53例疗效观察;滕兆礼等;《中国临床医生》;20011231;第29卷(第6期);39-40 * |
| 金世元主编.前列舒丸.《中成药的合理使用》.人民卫生出版社,2002,170-171. * |
| 高效液相色谱法测定前列舒丸中马钱苷含量;孙冻梅;《中国药业》;20111231;第20卷(第11期);40-41 * |
| 黄芩总苷对大鼠急慢性前列腺炎影响的实验研究;戴岳等;《中医药学刊》;20030331;第21卷(第3期);386-387 * |
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Address after: 100097 3F, block B, Jinyuan times business center, lantianchang East Road, Haidian District, Beijing Patentee after: Beijing kangdini Pharmaceutical Co.,Ltd. Address before: 100097 3F, block B, Jinyuan times business center, lantianchang East Road, Haidian District, Beijing Patentee before: BEIJING CONTINENT PHARMACEUTICAL Co.,Ltd. |