CN105412596A - Traditional Chinese medicine composition for treating liver tumors and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating liver tumors and preparation method thereof Download PDFInfo
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- CN105412596A CN105412596A CN201510838683.2A CN201510838683A CN105412596A CN 105412596 A CN105412596 A CN 105412596A CN 201510838683 A CN201510838683 A CN 201510838683A CN 105412596 A CN105412596 A CN 105412596A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating liver tumors and a preparation method thereof. The traditional Chinese medicine composition is prepared from sculellaria barbata, prunella vulgaris, wall geckoes, toad powder, black nightshade, Clerodendrum thomsoniae Balf, livistona chinensis, dandelion, tulip bulbs, radix isatidis, a spreading hedyotis herb, lightyellow sophora roots, kudzu vine roots, viscum liquidambaricolum hayata, centipedes and salvia miltiorrhiza. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, eliminating stagnation and relieving pain and can improve the liver cancer treating effect and prolong the survival time.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of liver tumor and preparation method thereof.
Background technology
In Chinese medicine, think liver tumor mainly due to the invasion such as damp and hot, exogenous pathogen, cold-evil health according to the Etiologic Mechanism of liver tumor and clinical symptoms, add due to unhygienic diet the generation that impairing the spleen and stomach, qi depression to blood stasis and the pent-up of feelings will etc. cause disease.Can know from the viewpoint of the traditional Chinese medical science, the reason causing liver damage phenomenon to occur is diversified, mainly contains following a few class: diet is variable, causes taste impaired, and board and lodging is stagnated, and makes humidogene expectorant, strongly fragrant and heat-transformation; Through rage, liver damage.
Chinese traditional treatment liver tumor can be divided into Types Below:
1, liver-heat blood stasis type: upper abdomen distension, pain with tenderness, can touch hard enclosed mass, and the breast side of body alters pain, restlessness and fever with thirst, and bitter taste is for drink, and dry stool is drowned yellow.Or short red, skin is dry simple and unadorned, pale tongue or dark red, time have indentation, tongue is thick in vain, wiry and frequent pulse or stringy and rolling pulse strong.Control and work as removing liver heat and toxic substances, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, ridging primordial QI reinforcing.
2, excess of liver-QI spleen-deficient: show as upper abdomen enclosed mass, swollen top is uncomfortable, and become thin weak, asthenia is breathed hard, abdominal distention and anorexia, very swollen after food, and difference of sleeping is changed one's position, and xerostomia is not drunk, large loose stool number, and drown yellow short, very then jaundice, ascites, edema of lower limbs, body of the tongue is fat, and tongue is greasy in vain, stringy and thready pulse.Rule for the treatment of invigorating the spleen and benefiting QI, eliminating pathogen in the liver disappears knot.
3, liver-kidney Yin deficiency type: performance expansion limb swells, frog abdomen blue veins, and extremity are skinny and wizened, dyspnea with rapid and short breath of losing heart, the deep red xerostomia of lip, indigestion and loss of appetite sitophobia, irritated sleeplessness, short just number of drowning, notably obnubilation, speaking incoherently, seek clothing and touch bed, or upper and lower blood oozing from the body openings or subcuta neous tissue, tongue light no fur, deep red tongue, thready and rapid pulse without strength.Control suitable replenishing the kidney(water)to nourish the liver(wood), QI invigorating nourishing YIN.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of liver tumor;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method for the treatment of liver tumor.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition for the treatment of liver tumor of the present invention, it is prepared from by the raw material comprising following weight portion:
Herba Scutellariae Barbatae 10-30 part, Spica Prunellae 10-30 part, Gekko Swinhonis 5-20 part, Bufo siccus powder 5-20 part processed, Herba Solani Nigri 10-30 part, Clerodendrum thomsonae Balf. 10-30 part, Chinese fanpalm seed 10-30 part, Herba Taraxaci 10-30 part, Pseudobulbus Cremastrae Seu Pleiones 10-30 part, Radix Isatidis 10-30 part, Herba Hedyotidis Diffusae 10-30 part, Radix Sophorae Flavescentis 10-30 part, flower of Radix Puerariae 10-30 part, Ramulus et Folium Visciarticulati 10-30 part, Scolopendra 5-20 part, Radix Salviae Miltiorrhizae 10-30 part.
Preferably, be prepared from by the raw material comprising following weight portion:
Herba Scutellariae Barbatae 12-20 part, Spica Prunellae 12-20 part, Gekko Swinhonis 8-15 part, Bufo siccus powder 8-15 part processed, Herba Solani Nigri 12-20 part, Clerodendrum thomsonae Balf. 12-20 part, Chinese fanpalm seed 12-20 part, Herba Taraxaci 12-20 part, Pseudobulbus Cremastrae Seu Pleiones 12-20 part, Radix Isatidis 12-20 part, Herba Hedyotidis Diffusae 12-20 part, Radix Sophorae Flavescentis 12-20 part, flower of Radix Puerariae 12-20 part, Ramulus et Folium Visciarticulati 12-20 part, Scolopendra 8-15 part, Radix Salviae Miltiorrhizae 12-20 part.
Below the crude drug source of Chinese medicine composition of the present invention:
Herba Scutellariae Barbatae is the dry herb of labiate Herba Scutellariae Barbatae ScutellariabarbataDon [S.rivularisWall].Pungent, bitter, cold.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
Spica Prunellae is the dry fruit ear of labiate Spica Prunellae PrunellavulgarisL..Pungent, bitter, cold.Return liver, gallbladder meridian.Relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Gekko Swinhonis, Geckonidae animal, without wart Gekko Swinhonis GekkosubpalmatusGunther, is used as medicine with dry entirety.Salty, cold.Slightly poisonous.Dispel the wind, active, eliminating stagnation.For paralysis due to windstroke, rheumatic arthritis, osteomyelitis, tuberculous lymphadenitis, tumor.
Bufo siccus powder processed, for Bufonidae animal Bufo siccus or Bufo melanostictus etc. decaptitate, after skin, gallbladder, clean and dry, be broken into powder.Enter the heart, liver, spleen, lung four warp.Broken crux, row water wets, removing toxic substances, parasite killing, analgesic therapy.Control furuncle, carbuncle on the back, carbuncle of yin nature scrofula, malignant boil, the lump in the abdomen hypochondriac lump, tympanites, edema, infantile malnutrition, chronic tracheitis.
Herba Solani Nigri is Solanaceae nightshade Herba Solani Nigri SolanumnigrumL., with all herbal medicine.Hardship, cold.Slightly poisonous.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cat fever, toothache, chronic bronchitis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle is controlled in external, pemphigus, venom.
Clerodendrum thomsonae Balf., formal name used at school: ClerodendrumthomsonaeBalf., Verenaceae shrub.Treatment furuncle furuncle and phyma, treating swelling and pain by traumatic injury, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.
Chinese fanpalm seed, Livistonachinensis(Jacq.) R.Br. is the seed of babassu Semen livistonae chinensis.Sweet in the mouth; Bitter; Property is put down; Mild toxicity.Blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.
Herba Taraxaci is feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or the dry herb belonging to several plants together.Bitter, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Pseudobulbus Cremastrae Seu Pleiones is orchid Cremastra appendiculata Cremastraappendiculata(D.Don) Makino, pleione bulbocodioides Pleionebulbocodioides(Franch.) the dry pseudobulb of Rolfe or Pleione yunnanensis PleioneyunnanensisRolfe.Sweet, micro-pungent, cool.Return liver, spleen channel.Heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.For carbuncle furunculosis, scrofula sucutaneous nodule, tuberculous lymphadenitis, snake bite and insect sting.
Radix Isatidis is the dry root of cruciferae isatis IsatisindigoticaFort..Hardship, cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Herba Hedyotidis Diffusae is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae HedyotisdiffusaWilld. [Oldenlandiadiffusa(Willd.) Roxb.].Sweet, light, cool.Enter stomach, large intestine, small intestine meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.
Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis SophoraflavescensAit..Hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Flower of Radix Puerariae is the dry flower of leguminous plant Pueraria lobota.There is the function of detoxifying and being amusing.Nature and flavor are sweet flat, kind alcoholic intoxication, and stomach function regulating of being amusing quenches one's thirst, and cure mainly the diseases such as insobriety headache and dizziness, excessive thirst vomiting, chest and diaphragm be glutted.
Ramulus et Folium Visciarticulati, Loranthaceae mistletoe Viscμm articulatum Burm f. ViscumarticulatumBurm.f., is used as medicine with Herb.Micro-hardship, flat.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis.For rheumatic arthritis, lumbar muscle strain, metrorrhagia, epistaxis, leucorrhea, urinary tract infection.
Scolopendra is the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH ScolopendrasubspinipesmutilansL.Koch.Pungent, temperature; Poisonous.Return Liver Channel.Endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBunge..Hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.Concrete preparation method is as follows:
Scheme one: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme two: get whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme three: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The Chinese medicine composition for the treatment of liver tumor of the present invention, with pharmaceutically acceptable carrier combination, can also make various oral formulations, as tablet, capsule, oral liquid, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 4: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
Method 5: oral liquid
Get one of scheme one to scheme three gained active component, dissolve after-purification, concentrate, add oral liquid and commonly use adjuvant, production method is prepared into oral liquid of the present invention routinely.
Above-mentioned oral liquid is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
The applicant is reference modern pharmacological research achievement on the basis of research tradition tcm syndrome differentiation and treatment, through test for many years, multiple formulations is screened, have found the Chinese medicine formula effectively treating liver tumor, Herba Scutellariae Barbatae, Herba Solani Nigri, Clerodendrum thomsonae Balf., Radix Isatidis, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing in side; Spica Prunellae relieves inflammation or internal heat eliminating stagnation; Gekko Swinhonis dispelling wind-evil and transforming calculus; Bufo siccus powder processed breaks crux, and row water wets, removing toxic substances pain relieving; Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving; Herba Taraxaci, Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Radix Sophorae Flavescentis heat clearing and damp drying; Flower of Radix Puerariae removing toxic substances is amusing; Ramulus et Folium Visciarticulati dispelling, collateral-activating; Scolopendra endogenous wind stopping spasmolytic, merit poison eliminating stagnation; Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing.Full side works in coordination with mutually, has effect of heat-clearing and toxic substances removing, removing obstruction for relieving pain, can improve liver cancer treatment effect, extends the time-to-live.
A kind of Chinese medicine composition for the treatment of liver tumor provided by the invention has the following advantages:
1, composite preparation provided by the invention is safe and effective, has effect of heat-clearing and toxic substances removing, removing obstruction for relieving pain, can improve liver cancer treatment effect, extends the time-to-live.
2, prove through clinical trial, patient, after traditional Chinese medicine composition for treating of the present invention, is 67.44% to the total effective rate of liver tumor, and can alleviates the clinical symptoms of liver tumor.
3, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, and mouthfeel is good, and cost is low.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 tablet
Take Herba Scutellariae Barbatae 1kg, Spica Prunellae 1kg, Gekko Swinhonis 0.5kg, Bufo siccus powder 0.5kg processed, Herba Solani Nigri 1kg, Clerodendrum thomsonae Balf. 1kg, Chinese fanpalm seed 1kg, Herba Taraxaci 1kg, Pseudobulbus Cremastrae Seu Pleiones 1kg, Radix Isatidis 1kg, Herba Hedyotidis Diffusae 1kg, Radix Sophorae Flavescentis 1kg, flower of Radix Puerariae 1kg, Ramulus et Folium Visciarticulati 1kg, Scolopendra 0.5kg, Radix Salviae Miltiorrhizae 1kg.Extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 2 tablet
Take Herba Scutellariae Barbatae 3kg, Spica Prunellae 3kg, Gekko Swinhonis 2kg, Bufo siccus powder 2kg processed, Herba Solani Nigri 3kg, Clerodendrum thomsonae Balf. 3kg, Chinese fanpalm seed 3kg, Herba Taraxaci 3kg, Pseudobulbus Cremastrae Seu Pleiones 3kg, Radix Isatidis 3kg, Herba Hedyotidis Diffusae 3kg, Radix Sophorae Flavescentis 3kg, flower of Radix Puerariae 3kg, Ramulus et Folium Visciarticulati 3kg, Scolopendra 2kg, Radix Salviae Miltiorrhizae 3kg.With 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3 granule
Take Herba Scutellariae Barbatae 1.2kg, Spica Prunellae 1.2kg, Gekko Swinhonis 0.8kg, Bufo siccus powder 0.8kg processed, Herba Solani Nigri 1.2kg, Clerodendrum thomsonae Balf. 1.2kg, Chinese fanpalm seed 1.2kg, Herba Taraxaci 1.2kg, Pseudobulbus Cremastrae Seu Pleiones 1.2kg, Radix Isatidis 1.2kg, Herba Hedyotidis Diffusae 1.2kg, Radix Sophorae Flavescentis 1.2kg, flower of Radix Puerariae 1.2kg, Ramulus et Folium Visciarticulati 1.2kg, Scolopendra 0.8kg, Radix Salviae Miltiorrhizae 1.2kg.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 4 capsule
Take Herba Scutellariae Barbatae 2kg, Spica Prunellae 2kg, Gekko Swinhonis 1.5kg, Bufo siccus powder 1.5kg processed, Herba Solani Nigri 2kg, Clerodendrum thomsonae Balf. 2kg, Chinese fanpalm seed 2kg, Herba Taraxaci 2kg, Pseudobulbus Cremastrae Seu Pleiones 2kg, Radix Isatidis 2kg, Herba Hedyotidis Diffusae 2kg, Radix Sophorae Flavescentis 2kg, flower of Radix Puerariae 2kg, Ramulus et Folium Visciarticulati 2kg, Scolopendra 1.5kg, Radix Salviae Miltiorrhizae 2kg.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, in extractum, add supplementary product starch, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method.
Embodiment 5 oral liquid
Take Herba Scutellariae Barbatae 1.5kg, Spica Prunellae 1.5kg, Gekko Swinhonis 1kg, Bufo siccus powder 1kg processed, Herba Solani Nigri 1.5kg, Clerodendrum thomsonae Balf. 1.5kg, Chinese fanpalm seed 1.5kg, Herba Taraxaci 1.5kg, Pseudobulbus Cremastrae Seu Pleiones 1.5kg, Radix Isatidis 1.5kg, Herba Hedyotidis Diffusae 1.5kg, Radix Sophorae Flavescentis 1.5kg, flower of Radix Puerariae 1.5kg, Ramulus et Folium Visciarticulati 1.5kg, Scolopendra 1kg, Radix Salviae Miltiorrhizae 1.5kg.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds adjuvant mannitol, sorbic acid, water stirs in extractum, subpackage, obtained oral liquid.
Embodiment 6 granule
Take Herba Scutellariae Barbatae 1.8kg, Spica Prunellae 1.8kg, Gekko Swinhonis 1.2kg, Bufo siccus powder 1.2kg processed, Herba Solani Nigri 1.8kg, Clerodendrum thomsonae Balf. 1.8kg, Chinese fanpalm seed 1.8kg, Herba Taraxaci 1.8kg, Pseudobulbus Cremastrae Seu Pleiones 1.8kg, Radix Isatidis 1.8kg, Herba Hedyotidis Diffusae 1.8kg, Radix Sophorae Flavescentis 1.8kg, flower of Radix Puerariae 1.8kg, Ramulus et Folium Visciarticulati 1.8kg, Scolopendra 1.2kg, Radix Salviae Miltiorrhizae 1.8kg.Extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 7 syrup
Take Herba Scutellariae Barbatae 2.5kg, Spica Prunellae 2.5kg, Gekko Swinhonis 1.8kg, Bufo siccus powder 1.8kg processed, Herba Solani Nigri 2.5kg, Clerodendrum thomsonae Balf. 2.5kg, Chinese fanpalm seed 2.5kg, Herba Taraxaci 2.5kg, Pseudobulbus Cremastrae Seu Pleiones 2.5kg, Radix Isatidis 2.5kg, Herba Hedyotidis Diffusae 2.5kg, Radix Sophorae Flavescentis 2.5kg, flower of Radix Puerariae 2.5kg, Ramulus et Folium Visciarticulati 2.5kg, Scolopendra 1.8kg, Radix Salviae Miltiorrhizae 2.5kg.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 8 mixture
Take Herba Scutellariae Barbatae 2.3kg, Spica Prunellae 2.3kg, Gekko Swinhonis 2.3.5kg, Bufo siccus powder 2.3.5kg processed, Herba Solani Nigri 2.3kg, Clerodendrum thomsonae Balf. 2.3kg, Chinese fanpalm seed 2.3kg, Herba Taraxaci 2.3kg, Pseudobulbus Cremastrae Seu Pleiones 2.3kg, Radix Isatidis 2.3kg, Herba Hedyotidis Diffusae 2.3kg, Radix Sophorae Flavescentis 2.3kg, flower of Radix Puerariae 2.3kg, Ramulus et Folium Visciarticulati 2.3kg, Scolopendra 2.3.5kg, Radix Salviae Miltiorrhizae 2.3kg.Extracting in water 3 times, three amount of water are equivalent to 2 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, filtrate is concentrated into 3 times that gross weight is medical material gross weight, fill, add mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, obtained mixture.
Embodiment 9 powder
Take Herba Scutellariae Barbatae 1.2kg, Spica Prunellae 1.5kg, Gekko Swinhonis 0.5kg, Bufo siccus powder 0.8kg processed, Herba Solani Nigri 1.8kg, Clerodendrum thomsonae Balf. 1kg, Chinese fanpalm seed 1kg, Herba Taraxaci 2kg, Pseudobulbus Cremastrae Seu Pleiones 1.2kg, Radix Isatidis 1.5kg, Herba Hedyotidis Diffusae 1.5kg, Radix Sophorae Flavescentis 1.5kg, flower of Radix Puerariae 1.8, Ramulus et Folium Visciarticulati 1.2kg, Scolopendra 1.2kg, Radix Salviae Miltiorrhizae 2kg.Pulverize, sieve, to obtain final product.
clinical trial
1 physical data
Observe 43 routine liver tumor patients, male 34 example, women 9 example.51 years old mean age, by hepatocarcinoma Chinese medical discrimination, belong to excess of liver-QI spleen-deficient 19 example, liver-heat blood stasis type 21 example, liver-kidney Yin deficiency type 3 example.Clinical stages, belongs to II phase hepatocarcinoma 38 example, I phase hepatocarcinoma 5 example.
2 evaluation criterias
Formulate criterion of therapeutical effect according to WHO standard, after getting involved, January checks epigastrium CT result.Score by complete incidence graph (CR), partial rcsponse (PR), stable (NC), progress (PD) 4 grades evaluation gross tumor volume change and Ka Shi.
Total effective rate=(CR+PR)/n
3 Therapeutic Method
Giving the embodiment of the present invention 6 Granules in Treating, each 10g, every day 3 times, 45 days is a course for the treatment of.
4 results
Through the treatment of two courses for the treatment of, clinical efficacy is in table 1.
Table 1 the present invention treats the clinical efficacy of liver tumor
| n | CR | PR | NC | PD | Total effective rate (%) | |
| Curative effect | 43 | 4 | 25 | 12 | 2 | 67.44 |
As shown in Table 1, after the treatment of two courses for the treatment of, the present invention is 67.44% to the total effective rate of kidney liver tumor.Result shows: Chinese medicine composition of the present invention has good therapeutical effect to liver tumor, and can alleviate the clinical symptoms of liver tumor.
model case
Liu xx, man, 53 years old, is diagnosed as primary hepatocarcinoma 2 years.The two lower limbs edema of patient, feels run-down, oral ulcer, without heating, without cough and expectoration, nervous after movable, receive dormancy can, defecate shapeless, every day, urine was measured many, and dark tongue quality tongue is greasy in vain, stringy pulse for several times.Give the embodiment of the present invention 5 to treat.More than patient consumes's first quarter moon, oral ulcer disappears, and muscle power is comparatively front to take a turn for the better, and following the service, if all diseases are lost, without significant discomfort.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. treat a Chinese medicine composition for liver tumor, it is characterized in that it is made up of the raw material of Chinese medicine comprising following weight portion: Herba Scutellariae Barbatae 10-30 part, Spica Prunellae 10-30 part, Gekko Swinhonis 5-20 part, Bufo siccus powder 5-20 part processed, Herba Solani Nigri 10-30 part, Clerodendrum thomsonae Balf. 10-30 part, Chinese fanpalm seed 10-30 part, Herba Taraxaci 10-30 part, Pseudobulbus Cremastrae Seu Pleiones 10-30 part, Radix Isatidis 10-30 part, Herba Hedyotidis Diffusae 10-30 part, Radix Sophorae Flavescentis 10-30 part, flower of Radix Puerariae 10-30 part, Ramulus et Folium Visciarticulati 10-30 part, Scolopendra 5-20 part, Radix Salviae Miltiorrhizae 10-30 part.
2. the Chinese medicine composition for the treatment of liver tumor as claimed in claim 1, is characterized in that it is made up of the raw material of Chinese medicine comprising following weight portion:
Herba Scutellariae Barbatae 12-20 part, Spica Prunellae 12-20 part, Gekko Swinhonis 8-15 part, Bufo siccus powder 8-15 part processed, Herba Solani Nigri 12-20 part, Clerodendrum thomsonae Balf. 12-20 part, Chinese fanpalm seed 12-20 part, Herba Taraxaci 12-20 part, Pseudobulbus Cremastrae Seu Pleiones 12-20 part, Radix Isatidis 12-20 part, Herba Hedyotidis Diffusae 12-20 part, Radix Sophorae Flavescentis 12-20 part, flower of Radix Puerariae 12-20 part, Ramulus et Folium Visciarticulati 12-20 part, Scolopendra 8-15 part, Radix Salviae Miltiorrhizae 12-20 part.
3. the Chinese medicine composition for the treatment of liver tumor as claimed in claim 1 or 2, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
4. the Chinese medicine composition for the treatment of liver tumor as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
5. the Chinese medicine composition for the treatment of liver tumor as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
6. the Chinese medicine composition for the treatment of liver tumor as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, alcohol content is made to be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtain active component.
7. treat a Chinese medicine composition for liver tumor, be prepared from by the Chinese medicine composition of the treatment liver tumor described in claim 1 or 2 and pharmaceutically acceptable carrier combination.
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| CN106924503A (en) * | 2017-04-24 | 2017-07-07 | 吴功胜 | It is a kind of to treat Chinese medicine composition of liver cancer and preparation method thereof |
| CN106924616A (en) * | 2017-05-22 | 2017-07-07 | 何东良 | A kind of Chinese medicine composition and its preparation for treating nasopharyngeal carcinoma |
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| CN101125178A (en) * | 2007-08-27 | 2008-02-20 | 毕哲全 | Traditional Chinese medicine for treating tumor |
| CN103893481A (en) * | 2014-03-28 | 2014-07-02 | 陈林豪 | Traditional Chinese medicine watered pill preparation for treating intermediated or advanced-staged liver cancer |
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| CN101125178A (en) * | 2007-08-27 | 2008-02-20 | 毕哲全 | Traditional Chinese medicine for treating tumor |
| CN103893481A (en) * | 2014-03-28 | 2014-07-02 | 陈林豪 | Traditional Chinese medicine watered pill preparation for treating intermediated or advanced-staged liver cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924503A (en) * | 2017-04-24 | 2017-07-07 | 吴功胜 | It is a kind of to treat Chinese medicine composition of liver cancer and preparation method thereof |
| CN106924616A (en) * | 2017-05-22 | 2017-07-07 | 何东良 | A kind of Chinese medicine composition and its preparation for treating nasopharyngeal carcinoma |
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