CN105055835A - Traditional Chinese medicine composition used for treating female menopausal syndrome - Google Patents
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Abstract
The invention belongs to the field of traditional Chinese medicine, and more specifically relates to a traditional Chinese medicine composition used for treating female menopausal syndrome. The traditional Chinese medicine composition is prepared from, 25 parts of Melastoma dodecandrum Lour., 18 parts of Cyanotis, 20 parts of Rubustephrodes Hance, 12 parts of rhizoma rehmanniae, 12 parts of radix paeoniae rubra, 12 parts of fructus schisandrae chinensis, 10 parts of cortex albiziae, 10 parts of polygala tenuifolia, 12 parts of radix ophiopogonis, 12 parts of radix paeoniae alba, 12 parts of Angelica sinensis, 10 parts of Flos Albiziae, 6 parts of liquorice, 12 parts of cortex moutan, 12 parts of radix scrophulariae, 12 parts of radix trichosanthis, and 12 parts of Semen Ziziphi Spinosae. The traditional Chinese medicine composition can be used for treating female menopausal syndrome.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of female climacteric syndrome and its preparation method and application.
Background technology
Female climacteric syndrome refers to occur before and after postmenopausal women gonadal hormone fluctuation or a series of based on function disorder of autonomic nervous system caused by reducing, with one group of syndrome of neuropsychological symptom.Menopause can be divided into natural menopause and artificial menopause two kinds.Natural menopause refers to that in ovary, follicle is used up, or remaining follicle loses reaction to promoting sexual gland hormone, and follicle is no longer grown and secreted estrogen, can not stimulate endometrial growth, cause menopause.Artificial menopause refers to excision bilateral ovaries or stops ovarian function with additive method, as radiotherapy and chemotherapy etc.Hysterectomize separately and retain side or bilateral ovaries person, not as artificial menopause.Comparatively common clinically, because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of female climacteric syndrome safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of female climacteric syndrome disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of female climacteric syndrome, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Melastomatis Dodecandri 25 parts, 18 parts, thunderclap pasture and water, Wu Pao sting 20 parts, Radix Rehmanniae 12 parts, Radix Paeoniae Rubra 12 parts, Fructus Schisandrae Chinensis 12 parts, Cortex Albiziae 10 parts, Radix Polygalae 10 parts, Radix Ophiopogonis 12 parts, the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 12 parts, Flos Albiziae 10 parts, 6 parts, Radix Glycyrrhizae, Cortex Moutan 12 parts, Radix Scrophulariae 12 parts, Radix Trichosanthis 12 parts, Semen Ziziphi Spinosae 12 parts.
The described Chinese medicine composition being used for the treatment of female climacteric syndrome, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of female climacteric syndrome, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of Chinese medicine composition in preparation treatment female climacteric syndrome medicine being used for the treatment of female climacteric syndrome.
Herba Melastomatis Dodecandri is Genus Melastoma L. of Melastomataceae Herba Melastomatis Dodecandri MelastomadodecandrumLour., with all herbal medicine.Adopt root or herb autumn, clean and dry.Heat-clearing and toxic substances removing, expelling wind and removing dampness, tonifying blood and arresting bleeding.For preventing the lonely inflammation of epidemic cerebrospinal, enteritis, dysentery, lung abscess, pelvic inflammatory disease, metrorrhagia, anemia, leucorrhea, lumbago and skelalgia, rheumatic ostalgia, traumatic hemorrhage, venom.
Thunderclap pasture and water are the root of the blue Auricled Hedyotis Herb of Commelianaceae plant.Tonify deficiency, dehumidifying, relaxing muscles and tendons and activating QI and blood in the collateral.Control deficiency-heat not move back, oedema due to nephritis, rheumatic arthralgia, eczema.
Wu Pao thorn is Rosaceae rubus Rubus tephrodes RubustephrodesHance, is used as medicine with root, leaf and seed.Picking leaves in summer, adopt root and seed autumn, dry, the present invention is used as medicine with leaf.Root: expelling wind and removing dampness, promoting blood flow to regulate menstruation.For rheumatalgia, chronic hepatitis, diarrhoea, dysentery, traumatic injury, menoxenia.Leaf: hemostasis, removing toxic substances.Traumatic hemorrhage is controlled in external, carbuncle furuncle infections.Seed: QI invigorating benefit essence.For body is empty after being ill, neurasthenia.All the other medical materials are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks that climacteric is that kidney qi is by containing the performance turning and decline, mainly kidney yin deficiency type, principal character is the sign having hyperactivity of fire caused by deficiency of YIN, as vexed, insomnia, hectic fever, trick heat in the heart, constipation, yellowish urine, xerostomia, dryness of the tongue etc., pass through enriching yin and nourishing kidney, bone strengthening fills out marrow, dispersing the stagnated live-QI to relieve the stagnation of QI, invigorating the spleen and regulating the stomach, QI invigorating is reduced phlegm, blood circulation promoting and blood stasis dispelling is treated, Herba Melastomatis Dodecandri of the present invention, thunderclap pasture and water, Wu Pao stings heat-clearing and toxic substances removing, enriching yin and nourishing kidney are monarch drug, Radix Rehmanniae, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis, Cortex Albiziae, Radix Polygalae, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Flos Albiziae the liver and the kidney tonifying, tranquillizing and allaying excitement, supplementing QI for promoting the production of body fluid is ministerial drug, Radix Glycyrrhizae, Cortex Moutan, Radix Scrophulariae, Radix Trichosanthis, Semen Ziziphi Spinosae invigorating the spleen and regulating the stomach is adjuvant, mutual compatibility, female climacteric syndrome successful can be treated.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Melastomatis Dodecandri 25g, thunderclap pasture and water 18g, Wu Pao stings 20g, Radix Rehmanniae 12g, Radix Paeoniae Rubra 12g, Fructus Schisandrae Chinensis 12g, Cortex Albiziae 10g, Radix Polygalae 10g, Radix Ophiopogonis 12g, Radix Paeoniae Alba 12g, Radix Angelicae Sinensis 12g, Flos Albiziae 10g, Radix Glycyrrhizae 6g, Cortex Moutan 12g, Radix Scrophulariae 12g, Radix Trichosanthis 12g, Semen Ziziphi Spinosae 12g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Melastomatis Dodecandri 25g, thunderclap pasture and water 18g, Wu Pao stings 20g, Radix Rehmanniae 12g, Radix Paeoniae Rubra 12g, Fructus Schisandrae Chinensis 12g, Cortex Albiziae 10g, Radix Polygalae 10g, Radix Ophiopogonis 12g, Radix Paeoniae Alba 12g, Radix Angelicae Sinensis 12g, Flos Albiziae 10g, Radix Glycyrrhizae 6g, Cortex Moutan 12g, Radix Scrophulariae 12g, Radix Trichosanthis 12g, Semen Ziziphi Spinosae 12g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba Melastomatis Dodecandri 25g, thunderclap pasture and water 18g, Wu Pao stings 20g, Radix Rehmanniae 12g, Radix Paeoniae Rubra 12g, Fructus Schisandrae Chinensis 12g, Cortex Albiziae 10g, Radix Polygalae 10g, Radix Ophiopogonis 12g, Radix Paeoniae Alba 12g, Radix Angelicae Sinensis 12g, Flos Albiziae 10g, Radix Glycyrrhizae 6g, Cortex Moutan 12g, Radix Scrophulariae 12g, Radix Trichosanthis 12g, Semen Ziziphi Spinosae 12g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, traditional Chinese medicine composition for treating female climacteric syndrome of the present invention clinical research
4.1 general data: this Chinese medicine composition is applied to clinical observation female climacteric syndrome 80 cases, wherein, 47 ~ 53 years old age.The shortest person of the course of disease 6 months, most elder reaches 2 years, average 1.2 years.
4.2 diagnostic criterias: (1) menoxenia: be climacteric women the most generally, the most outstanding performance.Menstruation often postpones, and even some months is just risen once, also reduces gradually through amount.When estrogen is fewer and feweri, when endometrium can not have been caused to change, menstruation just stopped, and is called menopause.(2) battle array hot flush: be climacteric one of principal character, some women within climacteric because estrogenic level declines, in blood, calcium level also declines to some extent, have a burst of position to generate heat, blush, perspire, with dizzy, nervous, the persistent period be one or two minute or 12 minutes-15 minutes not etc.(3) cardiovascular and lipoidosis: coronary heart disease, diabetes may be occurred.(4) neural, mental disorder: the women had, blood pressure fluctuates comparatively obvious up and down, and instability of may being in a bad mood is emotional, personality change, hypomnesis etc.(5) motor system is degenerated: occur waist, back of the body limbs pain, scapulohumeral periarthritis, cervical spondylosis appear in some women.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) fully recovers: symptom and sign disappear.(2) take a turn for the better: symptom and sign alleviate or partial disappearance.(3) invalid: unchanged after treatment.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 40 | 19 | 17 | 4 | 90 |
| Blank group | 40 | 1 | 2 | 37 | 7.5 |
Visible, the medicine that the present invention obtains can safe and effective treatment female climacteric syndrome, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of female climacteric syndrome, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Melastomatis Dodecandri 25 parts, 18 parts, thunderclap pasture and water, Wu Pao sting 20 parts, Radix Rehmanniae 12 parts, Radix Paeoniae Rubra 12 parts, Fructus Schisandrae Chinensis 12 parts, Cortex Albiziae 10 parts, Radix Polygalae 10 parts, Radix Ophiopogonis 12 parts, the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 12 parts, Flos Albiziae 10 parts, 6 parts, Radix Glycyrrhizae, Cortex Moutan 12 parts, Radix Scrophulariae 12 parts, Radix Trichosanthis 12 parts, Semen Ziziphi Spinosae 12 parts.
2. be used for the treatment of the Chinese medicine composition of female climacteric syndrome as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of female climacteric syndrome as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in treatment female climacteric syndrome medicine of female climacteric syndrome according to claim 1.
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| CN105641511A (en) * | 2016-01-14 | 2016-06-08 | 傅智炫 | Chinese medicine composition for treating female climacteric syndrome and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102698104A (en) * | 2012-06-06 | 2012-10-03 | 张俊波 | Medicine for treating climacteric syndrome and preparation method |
| CN103599353A (en) * | 2013-11-15 | 2014-02-26 | 武汉新国峰科技开发有限公司 | Chinese patent medicine for inhibiting and calming nerves and preparation method thereof |
| CN104027568A (en) * | 2014-07-01 | 2014-09-10 | 崔新明 | Traditional Chinese medicine composition for treating climacteric syndrome and preparation method thereof |
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| CN102698104A (en) * | 2012-06-06 | 2012-10-03 | 张俊波 | Medicine for treating climacteric syndrome and preparation method |
| CN103599353A (en) * | 2013-11-15 | 2014-02-26 | 武汉新国峰科技开发有限公司 | Chinese patent medicine for inhibiting and calming nerves and preparation method thereof |
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| CN105641511A (en) * | 2016-01-14 | 2016-06-08 | 傅智炫 | Chinese medicine composition for treating female climacteric syndrome and preparation method and application thereof |
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