CN101049465A - Capsule of Chinese traditional medicine for treating cyclomastopathy - Google Patents
Capsule of Chinese traditional medicine for treating cyclomastopathy Download PDFInfo
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Abstract
A Chinese medicine in the form of capsule for treating mastoplasia is prepared from 18 Chinese-medicinal materials including cypress tuber, ash bark, Chuan-xiong rhizome, red sage root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine, particularly a kind of Chinese medicinal capsule for the treatment of cyclomastopathy.
Background technology
Cyclomastopathy is common gynecological disease, frequently-occurring disease.Relevant bibliographical information, its sickness rate accounts for the women of child-bearing age's 30~60%, and 30~50 years old is its onset peak age.The cyclomastopathy main clinical manifestation is mastalgia and the lump in breast relevant with menstrual phase, the characteristics of pain are distending pain of the breast, dull pain, twinge, mostly occur and before menstruation or in menstrual phase pain, increase the weight of, the whole menstrual phase of a few patients all has pain, and pain is sometimes to cervical region, axillary fossa, the inboard radiation of upper arm.The characteristics of lump are that general matter is tough and not hard, can be distributed in one-sided breast or bilateral breast, and a few patients is with nipple discharge.Cyclomastopathy is a kind of neither the inflammation pathological changes of non-tumor again, is based on the lobules of mammary gland and the slow pathological process of last ductal ectasia hypertrophy or cystic lesion eventually.The danger that the women who suffers from cyclomastopathy brings out breast carcinoma is 2~4 times of normal women.At present, doctor trained in Western medicine thinks that ovarian dysfunction, lutein and estrogen ratio disequilibrium, lutein secretion descend, estrogen increases, can cause mammoplasia, doctor trained in Western medicine adopts Drug therapys such as hormone to the treatment of this disease more, as androgen, potassium iodide, vitamin etc.The deficiency that this type of medicine exists is: oral potassium iodide, vitamin, can not effect a radical cure cyclomastopathy, and easily recurrence after the drug withdrawal; It is better to the endocrine therapeutic effect to take androgen, but is prone to side effect such as menoxenia, leukopenia and digestive tract, neurological symptom, and the patient is reluctant to accept more.Chinese medicine is called nodules of the breast to cyclomastopathy, thinks that its cause of disease is many to be caused due to the depression of liver-QI by factors such as spirit depressing, feelings will are not smooth.Mammary gland belongs to Liver Channel and follows capable position, depression of liver-QI, disorder of QI movement, then distending pain of the breast; Depression of liver-QI, the stagnation of QI is hematogenous blockage then, qi depression to blood stasis, distending pain of the breast or twinge appear in the stagnation of blood stasis QI-blood circulation; Depression of liver-QI, stagnation of liver-QI is violated spleen, dysfunction of the spleen in transportation, accumulatively wet raise phlegm, stagnation of Qi and phelgm, the newborn network of the stagnant obstruction of the stasis of blood forms lump; Or because of deficiency of the liver and kindey, the cold and deficiency of CHONG and REN meridians is due to tying in the phlegm-damp.But control from the Liver and kidney opinion mostly in clinical.Stagnation of liver-QI is depression of liver-QI and then produces blood stasis, expectorant with fixed attention; It is many based on insufficiency of kidney-YANG to suffer from a deficiency of the kidney, and yang-energy is warm, it is unable to agitate, and qi-blood-body fluid is stopped and is that the stasis of blood is an expectorant.With the stagnation of liver-QI cross-reference of suffering from a deficiency of the kidney, treatment is gone up can not be well-separated clinically, normal soothing the liver the kidney warming and usefulness.Therefore, the Therapeutic Principle of the traditional Chinese medical science is: soothing the liver strongly fragrant, the kidney warming is positive, promoting flow of QI and blood, relieving accumulation of pathogens reduces phlegm.At present the Chinese medicine to the treatment of cyclomastopathy is mainly Chinese patent medicines such as RUPIXIAO, and this medicine mainly is made up of 15 flavor Chinese medicines such as Cornu Cervi, Herba Taraxaci, Thallus Laminariae (Thallus Eckloniae), Caulis Spatholobi, Radix Notoginseng, Sargassum, Radix Scrophulariae, Flos Carthami, but this medicine cure rate is lower; In addition, also have asparagine, RUKUAIXIAO PIAN, RUKANG PIAN, breast peace sheet etc., these Chinese Traditional Medicines take often, take that dose is big, the cycle is long, cost is high, curative effect is also not ideal enough.
Summary of the invention
The object of the present invention is to provide a kind of therapeutic effect obviously, have no side effect, medical expense is low, short treating period, is exclusively used in a kind of Chinese medicinal capsule for the treatment of cyclomastopathy of treatment cyclomastopathy.
For reaching above purpose, the technical solution adopted in the present invention is: this a kind of Chinese medicinal capsule for the treatment of cyclomastopathy, it is characterized in that it is to be made Radix Bupleuri 5.0-6.5% by following raw materials by weight percent medicine, Rhizoma Cyperi 3.5-5.0%, Pericarpium Citri Reticulatae Viride 2.5-3.5%, Radix Aucklandiae 3.5-5.0%, Rhizoma Corydalis 5.0-6.5%, Rhizoma Chuanxiong 3.5-5.0%, Radix Salviae Miltiorrhizae 5.0-6.5%, Radix Angelicae Sinensis 3.5-5.0%, Radix Paeoniae Rubra 3.5-5.0%, Semen Persicae 3.5-5.0%, rhizoma sparganic 3.5-5.0%, Rhizoma Curcumae 3.5-5.0%, Fructus Trichosanthis 6.5-8.5%, Bulbus Fritillariae Thunbergii 3.5-5.0%, Sargassum 13.0-15.5%, Concha Ostreae 6.5-8.5%, Spica Prunellae 5.0-6.5%, Cornu Cervi 5.0-6.5%.The optimum weight percentage ratio of each material medicine of Chinese medicinal capsule of this treatment cyclomastopathy is: Radix Bupleuri 5.8%, Rhizoma Cyperi 4.3%, Pericarpium Citri Reticulatae Viride 2.9%, the Radix Aucklandiae 4.4%, Rhizoma Corydalis 5.8%, Rhizoma Chuanxiong 4.4%, Radix Salviae Miltiorrhizae 5.8%, Radix Angelicae Sinensis 4.4%, Radix Paeoniae Rubra 4.4%, Semen Persicae 4.4%, rhizoma sparganic 4.3%, Rhizoma Curcumae 4.3%, Fructus Trichosanthis 7.2%, Bulbus Fritillariae Thunbergii 4.3%, Sargassum 14.5%, Concha Ostreae 7.2%, Spica Prunellae 5.8%, Cornu Cervi 5.8%.
The preparation method of the Chinese medicinal capsule of this treatment cyclomastopathy, produce according to the following steps:
(a), take by weighing each material medicine by above-mentioned percentage by weight: Radix Bupleuri 5.0-6.5%, Rhizoma Cyperi 3.5-5.0%, Pericarpium Citri Reticulatae Viride 2.5-3.5%, Radix Aucklandiae 3.5-5.0%, Rhizoma Corydalis 5.0-6.5%, Rhizoma Chuanxiong 3.5-5.0%, Radix Salviae Miltiorrhizae 5.0-6.5%, Radix Angelicae Sinensis 3.5-5.0%, Radix Paeoniae Rubra 3.5-5.0%, Semen Persicae 3.5-5.0%, rhizoma sparganic 3.5-5.0%, Rhizoma Curcumae 3.5-5.0%, Fructus Trichosanthis 6.5-8.5%, Bulbus Fritillariae Thunbergii 3.5-5.0%, Sargassum 13.0-15.5%, Concha Ostreae 6.5-8.5%, Spica Prunellae 5.0-6.5%, Cornu Cervi 5.0-6.5%.After weighing up, the Sargassum in the prescription, Concha Ostreae, Spica Prunellae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Trichosanthis are added 5-8 water doubly, decoct 3 times, each 40-60 minute, filter, and filtrate is concentrated, be concentrated into the ratio that decocts medicine raw material prescription gross weight be till 1: 1, the mixed liquor of partially mixed medicine;
(b), the mixed liquor to the partially mixed medicine produced in (a) step adds ethanol again, alcoholic acid addition be partially mixed medicine mixed liquor 60%, under 25 ℃ of temperature, left standstill 48 hours, filter, must with the ethanol admixing medical solutions, recovery ethanol gets the dealcoholysis admixing medical solutions to there not being the alcohol flavor from the ethanol admixing medical solutions again;
(c), the Radix Bupleuri with in the prescription, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Semen Persicae, rhizoma sparganic, Rhizoma Curcumae, Bulbus Fritillariae Thunbergii, harts horn carbon is broken into fine powder and mixes, the mixing fine powders medicine of another part hybrid medicine;
(d), with the mixing fine powders medicine of the dealcoholysis admixing medical solutions that makes in (b) step and another part hybrid medicine of (c) making in the step fully mix thoroughly, oven dry, porphyrize, incapsulate at last, the heavy 0.5g of every capsules is finished medicines.
Instructions of taking: oral, every day 3 times, each 5, three months is a course of treatment.
The pharmacology of this Chinese medicinal capsule is: Radix Bupleuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Rhizoma Corydalis mainly are dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Semen Persicae, rhizoma sparganic, Rhizoma Curcumae mainly are the notes of the ancient Chinese that disappears of invigorating blood circulation; Fructus Trichosanthis, Bulbus Fritillariae Thunbergii, Sargassum, Concha Ostreae, Spica Prunellae mainly are resolving phlegm and softening hard masses, dispersing swelling and dissipating binds; Cornu Cervi, energy the kidney warming sun, promoting the circulation of blood detumescence are the main medicine of early sucking knot.
Clinical Application Analysis: from January, 2004 to 2005 year December, adopt the present invention to treat 160 routine cyclomastopathy patients altogether, data all derives from my breast disease out-patient department of institute, and patient age is between 21~55 years old; The course of disease 3 months~7 years; Pathological changes is positioned at a side breast person 55 examples, both sides person 105 examples; Be confined to 1 quadrant person 47 example, surpass 1 quadrant person 113 example; Periodicity mastalgia 48 examples, irregularities mastalgia 112 examples; Nipple discharge 25 examples.
Diagnostic criteria is: formulate diagnostic criteria with reference to the cyclomastopathy diagnosis that breast disease Professional Committee of Society of Surgery of Chinese Chinese medicine association formulates: (1) has mammary gland tumor, and how with mastalgia, continuous 3 months can not spontaneous remission; (2) using molybdenum palladium shadowgraph confirms; (3) get rid of breast carcinoma, mammary gland fibroadenoma and physiological mastalgia, as through fore udder distending pain, adolescence mastalgia and mastalgia.
Criterion of therapeutical effect: the cyclomastopathy criterion of therapeutical effect that breast disease Professional Committee of Society of Surgery of the Chinese Chinese medicine of reference association formulates is formulated criterion of therapeutical effect: recovery from illness: lump in breast, pain disappear, and drug withdrawal was not recurred in 3 months; Effectively: the lump major diameter dwindles 〉=and 1/3, symptoms such as pain are obviously improved; Invalid: the lump major diameter dwindles<and 1/3, symptoms such as pain do not have obvious improvement.
Therapeutic Method: obey at the eliminating cold for resuscitation mouth of a river after meal, every day 3 times, and each 5, take after three months and check, determine therapeutic effect.
Therapeutic outcome: by treatment, in 160 examples, cure 150 examples, cure rate is 93.75%; Effective 4 examples, effective percentage are 2.5%; Total effective 154 examples, total effective rate is 96.25%; Invalid 6 examples, inefficiency are 3.7%.
In therapeutic process, selected 160 routine patients else, adopt the RUPIXIAO treatment, made the treatment controlled observation with same Therapeutic Method.From results of comparison, adopt the present invention's treatment, its cure rate can improve 33.75%, and total effective rate can improve 32.5%, and inefficiency can reduce by 32.6%.
Adopt the present invention and RUPIXIAO to the forward and backward curative effect comparison sheet of cyclomastopathy patient treatment
Beneficial effect of the present invention is: compare with the medicine of the treatment cyclomastopathy of present use, therapeutic effect is more obvious, and has no side effect, low, the short treating period of medical expense.
Embodiment 1
Produce this Chinese medicinal capsule of 1000g material medicine.Take by weighing Radix Bupleuri 58g, Rhizoma Cyperi 43g, Pericarpium Citri Reticulatae Viride 29g, Radix Aucklandiae 44g, Rhizoma Corydalis 58g, Rhizoma Chuanxiong 44g, Radix Salviae Miltiorrhizae 58g, Radix Angelicae Sinensis 44g, Radix Paeoniae Rubra 44g, Semen Persicae 44g, rhizoma sparganic 43g, Rhizoma Curcumae 43g, Fructus Trichosanthis 72g, Bulbus Fritillariae Thunbergii 43g, Sargassum 145g, Concha Ostreae 72g, Spica Prunellae 58g, Cornu Cervi 58g.Its production stage is: (a) earlier the Sargassum in the above-mentioned prescription, Concha Ostreae, Spica Prunellae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Trichosanthis are added 7 times water, decoct each 50 minutes 3 times, filter, concentrate, the ratio that is concentrated into the prescription gross weight is till 1: 1, the mixed liquor of partially mixed medicine; (b), the mixed liquor to the partially mixed medicine produced in (a) step adds ethanol again, alcoholic acid addition be partially mixed medicine mixed liquor 60%, under 25 ℃, left standstill 48 hours, filter, must with the ethanol admixing medical solutions, recovery ethanol gets the dealcoholysis admixing medical solutions to there not being the alcohol flavor from the ethanol admixing medical solutions again; (c), the Radix Bupleuri with in the prescription, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Semen Persicae, rhizoma sparganic, Rhizoma Curcumae, Bulbus Fritillariae Thunbergii, harts horn carbon is broken into fine powder and mixes, the mixing fine powders medicine of another part hybrid medicine; (d), with the mixing fine powders medicine of the dealcoholysis admixing medical solutions that makes in (b) step and another part hybrid medicine of (c) making in the step fully mix thoroughly, oven dry, porphyrize, incapsulate at last, the heavy 0.5g of every capsules is finished medicines.
Model case
Li Yafang, the woman, 28 years old, married, Yang Li people from town, Laiwu City Laicheng district came me institute to go to a doctor on May 25th, 2004, and mastalgia has half a year, and bilateral breast can touch lump, is diagnosed as cyclomastopathy through molybdenum palladium shadowgraph.Take this capsule for treating, cured in 3 months, follow-up investigation 1 year is not seen recurrence.Similar case has 58 examples, adopts the Chinese medicinal capsule oral medication of this prescription, takes 3-5 month, all obtains curing.
Embodiment 2
Produce this Chinese medicinal capsule of 1000g material medicine.Take by weighing Radix Bupleuri 55g, Rhizoma Cyperi 41g, Pericarpium Citri Reticulatae Viride 30g, Radix Aucklandiae 50g, Rhizoma Corydalis 55g, Rhizoma Chuanxiong 50g, Radix Salviae Miltiorrhizae 54g, Radix Angelicae Sinensis 50g, Radix Paeoniae Rubra 35g, Semen Persicae 41g, rhizoma sparganic 35g, Rhizoma Curcumae 41g, Fructus Trichosanthis 75g, Bulbus Fritillariae Thunbergii 43g, Sargassum 150g, Concha Ostreae 80g, Spica Prunellae 65g, Cornu Cervi 50g.Its production stage is with embodiment 1.
Model case
Hao Langui, the woman, 32 years old, married, Yang Zhuan people from town, Laiwu City Laicheng district, come me institute to go to a doctor on June 10th, 2005, mastalgia has 4 months, and one-sided mammary gland can touch lump, is diagnosed as cyclomastopathy through molybdenum palladium shadowgraph, take this capsule, cured in 3 months, follow-up investigation 1 year is not seen recurrence.Similar case has 42 examples, has 40 examples to obtain curing in 3-6 month, though other has 2 example performances to alleviate, does not cure.
Embodiment 3
Produce this Chinese medicinal capsule of 1000g material medicine.Take by weighing Radix Bupleuri 65g, Rhizoma Cyperi 37g, Pericarpium Citri Reticulatae Viride 35g, Radix Aucklandiae 36g, Rhizoma Corydalis 65g, Rhizoma Chuanxiong 44g, Radix Salviae Miltiorrhizae 65g, Radix Angelicae Sinensis 36g, Radix Paeoniae Rubra 50g, Semen Persicae 44g, rhizoma sparganic 50g, Rhizoma Curcumae 43g, Fructus Trichosanthis 65g, Bulbus Fritillariae Thunbergii 35g, Sargassum 140g, Concha Ostreae 70g, Spica Prunellae 55g, Cornu Cervi 65g.Its production stage is with embodiment 1.
Model case
Chen Ping, the woman, 36 years old, Laiwu City Gangcheng District people came me institute to go to a doctor on August 28th, 2004.Mastalgia has 1 year, and bilateral breast can touch lump, is diagnosed as cyclomastopathy through molybdenum palladium shadowgraph.Take this capsule, 3 first quarter moons are cured, and follow-up investigation 1 year is not seen recurrence.Similar case has 50 examples, has 46 examples to obtain curing in half a year, and other has 4 examples invalid.
Claims (3)
1, a kind of Chinese medicinal capsule for the treatment of cyclomastopathy, it is characterized in that it is to be made Radix Bupleuri 5.0-6.5% by following raw materials by weight percent medicine, Rhizoma Cyperi 3.5-5.0%, Pericarpium Citri Reticulatae Viride 2.5-3.5%, Radix Aucklandiae 3.5-5.0%, Rhizoma Corydalis 5.0-6.5%, Rhizoma Chuanxiong 3.5-5.0%, Radix Salviae Miltiorrhizae 5.0-6.5%, Radix Angelicae Sinensis 3.5-5.0%, Radix Paeoniae Rubra 3.5-5.0%, Semen Persicae 3.5-5.0%, rhizoma sparganic 3.5-5.0%, Rhizoma Curcumae 3.5-5.0%, Fructus Trichosanthis 6.5-8.5%, Bulbus Fritillariae Thunbergii 3.5-5.0%, Sargassum 13.0-15.5%, Concha Ostreae 6.5-8.5%, Spica Prunellae 5.0-6.5%, Cornu Cervi 5.0-6.5%.
2, a kind of Chinese medicinal capsule for the treatment of cyclomastopathy according to claim 1 is characterized in that each material medicine optimum weight percentage ratio is: Radix Bupleuri 5.8%, Rhizoma Cyperi 4.3%, Pericarpium Citri Reticulatae Viride 2.9%, the Radix Aucklandiae 4.4%, Rhizoma Corydalis 5.8%, Rhizoma Chuanxiong 4.4%, Radix Salviae Miltiorrhizae 5.8%, Radix Angelicae Sinensis 4.4%, Radix Paeoniae Rubra 4.4%, Semen Persicae 4.4%, rhizoma sparganic 4.3%, Rhizoma Curcumae 4.3%, Fructus Trichosanthis 7.2%, Bulbus Fritillariae Thunbergii 4.3%, Sargassum 14.5%, Concha Ostreae 7.2%, Spica Prunellae 5.8%, Cornu Cervi 5.8%.
3, a kind of preparation method for the treatment of the Chinese medicinal capsule of cyclomastopathy according to claim 1 and 2 is characterized in that it is to produce according to the following steps:
(a), take by weighing each material medicine by above-mentioned percentage by weight: Radix Bupleuri 5.0-6.5%, Rhizoma Cyperi 3.5-5.0%, Pericarpium Citri Reticulatae Viride 2.5-3.5%, Radix Aucklandiae 3.5-5.0%, Rhizoma Corydalis 5.0-6.5%, Rhizoma Chuanxiong 3.5-5.0%, Radix Salviae Miltiorrhizae 5.0-6.5%, Radix Angelicae Sinensis 3.5-5.0%, Radix Paeoniae Rubra 3.5-5.0%, Semen Persicae 3.5-5.0%, rhizoma sparganic 3.5-5.0%, Rhizoma Curcumae 3.5-5.0%, Fructus Trichosanthis 6.5-8.5%, Bulbus Fritillariae Thunbergii 3.5-5.0%, Sargassum 13.0-15.5%, Concha Ostreae 6.5-8.5%, Spica Prunellae 5.0-6.5%, Cornu Cervi 5.0-6.5%.Sargassum in the prescription, Concha Ostreae, Spica Prunellae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Trichosanthis are added 5-8 water doubly, decoct 3 times, each 40-60 minute, filter, and filtrate concentrated, be concentrated into the ratio that decocts medicine raw material prescription gross weight be till 1: 1, the mixed liquor of partially mixed medicine;
(b), the mixed liquor to the partially mixed medicine produced in (a) step adds ethanol again, alcoholic acid addition be partially mixed medicine mixed liquor 60%, under 25 ℃ of temperature, left standstill 48 hours, filter, must with the ethanol admixing medical solutions, recovery ethanol gets the dealcoholysis admixing medical solutions to there not being the alcohol flavor from the ethanol admixing medical solutions again;
(c), the Radix Bupleuri with in the prescription, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Semen Persicae, rhizoma sparganic, Rhizoma Curcumae, Bulbus Fritillariae Thunbergii, harts horn carbon is broken into fine powder and mixes, the mixing fine powders medicine of another part hybrid medicine;
(d), with the mixing fine powders medicine of the dealcoholysis admixing medical solutions that makes in (b) step and another part hybrid medicine of (c) making in the step fully mix thoroughly, oven dry, porphyrize, incapsulate at last, the heavy 0.5g of every capsules is finished medicines.
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