CN104116771A - Red tablets with effect of promoting blood circulation and stopping pain and preparation method of red tablets - Google Patents
Red tablets with effect of promoting blood circulation and stopping pain and preparation method of red tablets Download PDFInfo
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Abstract
The invention relates to red tablets with an effect of promoting blood circulation and stopping pain. The red tablets are prepared from 80-90g of pseudo-ginseng, 20-30g of flos carthami, 15-25g of angelica sinensis, 15-25g of ligusticum wallichii, 15-25g of radix angelicae and 20-30g of ground beetles. The invention further provides a preparation method of the red tablets. The red tablets prepared by the method provided by the invention have the remarkable function of promoting blood circulation and stopping pain. Initial pharmacologic experimental and clinical application results show that the product is remarkable in effect of promoting blood circulation and stopping pain; due to adjustment of dosage ratio of raw medicinal materials, the cost of the raw medicinal materials of a single tablet is further lowered; and meanwhile, as the preparation process is improved, the dose of the medicine is reduced, so that the red tablets are more convenient to use.
Description
Technical field
Technical solution of the present invention is included into the field of Chinese medicines, relates to a kind of mercurochrome tablet with promoting blood circulation and stopping pain, promoting tissue regeneration by removing blood stasis effect and preparation method thereof.
Background technology
Orthopaedic disease belongs to a class multiple diseases in daily life, mostly needs the long period to cure, and greatly affects patient's orthobiosis.Western medical treatment is conventionally from anti-inflammatory analgesic, and endo-medicine is indometacin, ibuprofen etc. such as, the successful of analgesia, antiinflammatory, but all exist and can not take for a long time, and can only alleviating pain symptom, cannot play the problem of the effect of radical cure.Meanwhile, these medicines are larger to human liver injury of kidney, and side effect is obvious.
Chinese traditional treatment traumatic injury has the history of several thousand, ancient title " traumatic injury " is the introduction of all wounds, how because of External Force Acting, or in the situation of self fault, overexert and cause, contain because disharmony between QI and blood, muscles and bones trauma, congestion that External Force Acting causes in human body swell and ache, blockage of main and collateral channels is so that the disease such as internal organs are impaired.To be normal appearance and multiple a kind of orthopaedics sufferer in daily life due to traumatic injury, therefore at present various for the medicament categories of traumatic injury on the market, the conventional medicine with promoting blood circulation and stopping pain effect reaches dozens or even hundreds of kind, but all there is many-sided problem for the treatment of traumatic injury in these medicines, or the course for the treatment of is long, onset is slow, or medical expense is high, or DeGrain etc.
The 20th of ministry standard " Traditional Chinese medicine historical preparation " recorded a kind of " mercurochrome tablet ", made by Radix Notoginseng 750g, Rhizoma Chuanxiong 175g, Radix Angelicae Dahuricae 175g, Radix Angelicae Sinensis 175g, Eupolyphaga Seu Steleophaga 175g Flos Carthami 175g, also record a kind of " trauma treating Diedahongyao ", made by Radix Notoginseng 101.4g, Flos Carthami 23.6g, Radix Angelicae Sinensis 23.6g, Rhizoma Chuanxiong 23.6g, Radix Angelicae Dahuricae 23.6g and Eupolyphaga Seu Steleophaga 23.6g.Although these two kinds of mercurochrome tablet titles are slightly different, but its medical material composition and proportion relation are similar, in clinical use all to congestion swell and ache, the disease such as rheumatic numbness has obvious therapeutical effect, and because raw material only comprises 6 taste medical materials, cost is lower, is accepted by extensive patients.But rise along with the general of Chinese crude drug price in recent years, cause the price of Chinese patent medicine correspondingly to improve.In prior art, also have " Yunnan red tablet ", made by medical materials such as Radix Notoginseng, Rhizoma Paridis, Radix dactylicapni (Radix Dactylicapnotis), Delavay ampelopsis root, Pseudostreblus indica Bur., Radix seu Cortex Heteropanacis, Radix Psammosilenes, Rhizoma Acori Graminei, Radix Scutellariae, manufacture-yellow Radix Aconiti Kusnezoffii; " SHENYANG HONGYAO PIAN " is on the basis of " mercurochrome tablet ", to increase the product that Rhizoma Corydalis makes simply.As can be seen here, the Chinese patent medicine that mercurochrome tablet is extensively approved for a kind of quilt really, those skilled in the art have carried out omnibearing exploration and research to it, and have obtained corresponding achievement.
Therefore, in order to reduce costs better, improve the excessive shortcoming of dose that old preparation method causes, inventor has carried out further research and exploration to " mercurochrome tablet " accepted by extensive patients, maintaining under the constant prerequisite even increasing of drug effect, reduce as much as possible raw material consumption, and by preferred extraction process, obtain that a kind of effect is good, the mercurochrome tablet product of cost, and then obtain the present invention.
Summary of the invention
An object of the present invention is to provide a kind of mercurochrome tablet with promoting blood circulation and stopping pain effect, this product is evident in efficacy, with low cost, good mouthfeel, and every containing the crude drug extract being equivalent to more than mercurochrome tablet crude drug crude drug 0.25g.
Another object of the present invention is to provide the preparation method of above-mentioned promoting blood circulation and stopping pain effect mercurochrome tablet.
The crude drug of mercurochrome tablet of the present invention is as follows:
Radix Notoginseng 80-90g, Flos Carthami 20-30g, Radix Angelicae Sinensis 15-25g, Rhizoma Chuanxiong 15-25g, Radix Angelicae Dahuricae 15-25g and Eupolyphaga Seu Steleophaga 20-30g.
Further, Radix Notoginseng 83-88g, Flos Carthami 25-30, Radix Angelicae Sinensis 15-20, Rhizoma Chuanxiong 20-25g, Radix Angelicae Dahuricae 15-20g and Eupolyphaga Seu Steleophaga 25-30g.
Further, Radix Notoginseng 85-88g, Flos Carthami 25-28g, Radix Angelicae Sinensis 17-20g, Rhizoma Chuanxiong 21-24g, Radix Angelicae Dahuricae 17-20g and Eupolyphaga Seu Steleophaga 25-28g.
More specifically, Radix Notoginseng 85.8g, Flos Carthami 26.6g, Radix Angelicae Sinensis 19.2g, Rhizoma Chuanxiong 23.6g, Radix Angelicae Dahuricae 19.2g and Eupolyphaga Seu Steleophaga 26.6g.
More specifically, Radix Notoginseng 88g, Flos Carthami 27g, Radix Angelicae Sinensis 17.5g, Rhizoma Chuanxiong 21g, Radix Angelicae Dahuricae 17g and Eupolyphaga Seu Steleophaga 27g.
The present invention also provides the preparation method of the above-mentioned mercurochrome tablet with promoting blood circulation and stopping pain effect, comprises the following steps:
(1) weighting raw materials in proportion, mixes after pulverizing;
(2) in crude drug, add the distilled water of 6-8 times of weight, and add enzyme, keep temperature 40-60 degree Celsius, carry out enzymolysis processing 1-3 hour;
(3) by the mixture boiled after enzymolysis 10 minutes, make, after enzyme-deactivating, to be cooled to room temperature, isolate filtrate 1 and filtering residue 1;
(4) get filtrate 1, be evaporated to 1/3rd, centrifugal, obtain extracting solution 1;
(5) get filtering residue 1, add 75% ethanol-n-butyl alcohol mixed solution, be adjusted to pH=7-9 with alkali, reflux, extract, 2-5 hour, separates and obtains filtrate 2 and filtering residue 2;
(6) merge extractive liquid, 1 and filtrate 2, add 0.1% active carbon by weight, filters, and being concentrated into relative density is 1.05-1.12, obtains concentrated solution; Further be concentrated into thick paste shape;
(7) add appropriate filler, disintegrating agent, correctives, mix homogeneously, makes tablet through soft material processed, granulation, dry, tablet forming technique, and every containing the crude drug extract being equivalent to more than mercurochrome tablet crude drug crude drug 0.25g.
Wherein, preferably, in step (2), enzyme is selected from trypsin, cathepsin, pepsin, cellulase or its compositions, preferably the compound enzyme of trypsin and cellulase 2:1 or cathepsin and cellulase 2:1.
Preferably, in step (5), 75% ethanol-n-butyl alcohol mixed solution refers to the mixed solution of 75% ethanol-n-butyl alcohol (3:1).
Preferably, in step (7), filler is selected from dextrin, Pulvis Talci, microcrystalline Cellulose or its mixture, most preferably the compositions of Pulvis Talci and microcrystalline Cellulose 1:1; Disintegrating agent is selected from carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, most preferably low-substituted hydroxypropyl cellulose.
Instructions of taking: get tablet of the present invention, 1 time 1,3 times on the one, oral.
The inventor has spent plenty of time and work, the consumption proportion relation of mercurochrome tablet crude drug studied, and by the screening to preparation technology, in the hope of the technical scheme that obtains a kind of effect significantly and cost is minimized.Below will introduce in detail R&D process of the present invention and beneficial effect.
One, the research of crude drug proportion relation
The 20th of ministry standard " Traditional Chinese medicine historical preparation " recorded two kinds of mercurochrome tablets, respectively " mercurochrome tablet ", made by Radix Notoginseng 750g, Rhizoma Chuanxiong 175g, Radix Angelicae Dahuricae 175g, Radix Angelicae Sinensis 175g, Eupolyphaga Seu Steleophaga 175g Flos Carthami 175g, and " trauma treating Diedahongyao ", made by Radix Notoginseng 101.4g, Flos Carthami 23.6g, Radix Angelicae Sinensis 23.6g, Rhizoma Chuanxiong 23.6g, Radix Angelicae Dahuricae 23.6g and Eupolyphaga Seu Steleophaga 23.6g.
Therefore, in order to reduce costs better, improve the excessive shortcoming of dose that old preparation method causes, first inventor studies the proportion relation of mercurochrome tablet 6 taste raw medicinal materials used, attempt to find out more applicable crude drug proportion relation, with maintaining under the constant prerequisite even increasing of drug effect, reduce as much as possible raw material consumption.On this basis, the inventor surprisingly finds, Flos Carthami and Eupolyphaga Seu Steleophaga exist unique relatedness in this side, and then proposes the present invention.
The Experimental agents adopting:
Chinese crude drug is purchased from Beijing Tongrentang, and after being mixed in proportion respectively, the 1000ml that adds water, decocts 30 minutes, and after filtration, the slag of the getting it filled 1000ml that adds water again decocts 30 minutes, merges decocting liquid twice, is concentrated into 200ml, makes water extraction liquid, for subsequent use.
1, experiment material
Kunming mouse, body weight 18-22g, 140; Standard male Wistar rat, body weight 190-220g, 70; Medicine: 6 kinds of water extraction liquid, 0.7% acetic acid that said method makes.
2, experimental technique and result
2.1 analgesic effect
Get above-mentioned mice, be divided at random 7 groups by body weight, 20 every group, wherein 6 treated animals gastric infusion 0.2ml/g said extracted liquid respectively, blank group gives the distilled water of same volume, every day 1 time, successive administration 10 days, 1 hour pneumoretroperitoneum of last administration is injected 0.7% acetic acid 0.1mg/g.Observe the writhing response number of times that in 15 minutes, each treated animal is caused by acetic acid, the results are shown in following table.
(compared with blank group, * P ﹤ 0.05, * * P ﹤ 0.01)
(compared with existing combination, Δ P ﹤ 0.05)
The effect of 2.2 pairs of ecchymosis
Get above-mentioned rat, be divided at random 7 groups by body weight, 10 every group, within first 18 hours, remove rat back Mus hair, 5*4cm in experiment
2.With this depilation region of mouse clamp, cause subcutaneous hemorrhage.After 12 hours, by 0.2ml/g dosage gastric infusion, wherein 1 group gives the distilled water of same volume.Administration every day 1 time, successive administration 7 days, perusal swelling and the ecchymosis situation that disappears when administration, measures residual area, carries out integration, using its total score as ecchymosis severity, the results are shown in following table.
The standards of grading of ecchymosis
On the impact of rat ecchymosis
(compared with blank group, * P ﹤ 0.05, * * P ﹤ 0.01)
(compared with existing combination, Δ P ﹤ 0.05)
As can be seen here, in the prerequisite that the present composition reduces at raw medicinal material consumption, still obtained significant effect.
Two, the screening of preparation method
1, the screening of enzymolysis step
1.1 experiment material
6 kinds of raw medicinal materials, cellulase, trypsin, pepsin, papain, cathepsin.Combine 1 proportion relation weighing medical material according to the present invention, pulverize, mix, take 240g for subsequent use, be divided into 12 parts, every part of 20g.
1.2 experimental technique
Taking decocting boil, water extract-alcohol precipitation is as contrast, relatively cellulase, trypsin, pepsin, papain, cathepsin and combination thereof the impact on total peptides extraction rate in compositions.Extracting method is, after pulverizing medicinal materials is mixed, and decocting group: add respectively 6 times of weight distilled water to decoct 3 times, each 10 minutes, filtrate filtered, and concentrating under reduced pressure becomes 100ml; Alcohol extraction group: add respectively 6 times of weight, 75% ethanol to decoct 3 times, each 10 minutes, decompression recycling ethanol, concentrating under reduced pressure becomes 100ml; Enzymolysis group: add 6 times of weight distilled water to boil 15 minutes, be cooled to after room temperature, add enzyme 2g, keep temperature 40-60 degree Celsius, carry out enzymolysis processing 1 hour, filter, concentrating under reduced pressure becomes 100ml.Measure total peptide yield of various extracting modes.
1.3 experimental result
The screening of table 5 enzyme class
As can be seen from the above table, enzymolysis, compared with traditional extraction technique, extracts fully, and efficiency is high, wherein, will after protease and cellulase combination, significantly promote the yield of total peptide, and this may mutually promote relevant to hydrolysing component in mixed material.
2, extract the selection of solvent
We have investigated the rate of transform of different solvents to arasaponin Flos Carthami saponin in the present composition (combination 1).By the filtering residue 120g after trypsin and cellulase 2:1 enzymolysis, be divided into 6 groups, every group of 20g, all extracts after crude drug the testing index composition rate of transform with following every kind of solvent.
The impact of table different solvents on Flos Carthami saponin and the arasaponin rate of transform
As can be seen here, 75% ethanol, n-butyl alcohol or its combination apparently higher than other solvent, have retained active component to the rate of transform of saponin component better.
3, the selection of adjuvant
The selection of 3.1 filleies
After the thick paste that preparation method step of the present invention (6) is made is pulverized, add respectively sucrose, lactose, dextrin, Pulvis Talci, starch, microcrystalline Cellulose adjuvant, investigate respectively granulating efficiency, melting, experimental result shows, dextrin, Pulvis Talci, microcrystalline Cellulose or its mixture have clear improvement to the viscosity of thick paste, granulating efficiency is better, and wherein the combined effect of Pulvis Talci and microcrystalline Cellulose 1:1 is best.
The effect expedition of table 6 filler
The selection of 3.2 disintegrating agents
Disintegrating agent is selected from carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, most preferably low-substituted hydroxypropyl cellulose.
The thick paste that preparation method step of the present invention (6) is made adds respectively starch, polyvinylpolypyrrolidone, ketopyrrolidine, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose after pulverizing, and investigates respectively disintegration and state.Experimental result shows, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose all can dissolve dispersion in 3 minutes, and wherein effect optimum is low-substituted hydroxypropyl cellulose.
The effect expedition of table disintegrating agent
Three, the confirmation of clinical efficacy
Choose contusion, sprain, tension injury patient, 80 examples, in age 20-60 year, men and women half and half.It is divided into two groups at random, and the mercurochrome tablet that the 40 routine administration embodiment of the present invention 1 make, takes medicine 3 every day, and each 17 days is a course for the treatment of; The existing compositions of 40 routine administration (trauma treating Diedahongyao), takes medicine 2 every day, and each 27 days is a course for the treatment of.
Criterion of therapeutical effect:
Alleviate completely: symptom, sign disappear, painless, sign is without vestige.
Partial rcsponse: conscious pain disappears not obvious, and sign vestige slightly exists;
Invalid: pain continues, sign vestige exists.
Result: effective percentage statistics
As can be seen here, the total effective rate of medicine of the present invention is better than existing trauma treating Diedahongyao.
Generally speaking, the mercurochrome tablet that adopts method of the present invention to prepare has remarkable promoting blood circulation and stopping pain effect.Show through preliminary pharmacological experiment and clinical practice result: the effect of this product promoting blood circulation and stopping pain is remarkable, and because of the adjustment of crude drug consumption proportion, also reduced the crude drug cost of monolithic tablet, the while is due to preparation technology's improvement, reduce the dose of medicine, be more convenient for using.
Detailed description of the invention
Below in conjunction with embodiment, this mercurochrome tablet is described further.Those skilled in the art should be able to understand, these embodiment are also not intended to invention protection domain to make restriction, and those skilled in the art can obtain similar scheme by the change of conventional means on the basis of the application's disclosure.
Embodiment 1
Have a mercurochrome tablet for promoting blood circulation and stopping pain effect, crude drug is: Radix Notoginseng 85.8g, Flos Carthami 26.6g, Radix Angelicae Sinensis 19.2g, Rhizoma Chuanxiong 23.6g, Radix Angelicae Dahuricae 19.2g and Eupolyphaga Seu Steleophaga 26.6g, and its preparation method comprises the following steps:
(1) weighting raw materials in proportion, mixes after pulverizing;
(2) to the distilled water that adds 6-8 times of weight in crude drug, add trypsin and cellulase (2:1) 20g, keep 50 degrees Celsius of temperature, carry out enzymolysis processing 2 hours;
(3) by the mixture boiled after enzymolysis 10 minutes, make, after enzyme-deactivating, to be cooled to room temperature, isolate filtrate 1 and filtering residue 1;
(4) get filtrate 1, be evaporated to 1/3rd, centrifugal, obtain extracting solution 1;
(5) get filtering residue 1, add 75% ethanol-n-butyl alcohol (3:1) mixed solution, with alkali adjusting pH to 8, reflux, extract, 3 hours, separates and obtains filtrate 2 and filtering residue 2;
(6) merge extractive liquid, 1 and filtrate 2, add 0.1% active carbon by weight, filters, and being concentrated into relative density is 1.05-1.12, obtains concentrated solution; Further be concentrated into thick paste shape;
(7) add appropriate Pulvis Talci and microcrystalline Cellulose (1:1), carboxymethyl starch sodium and appropriate correctives, mix homogeneously, through soft material processed, granulation, dry, tabletting, to obtain final product, and every containing the crude drug extract that is equivalent to mercurochrome tablet crude drug crude drug 0.3g.
Embodiment 2
Have a mercurochrome tablet for promoting blood circulation and stopping pain effect, crude drug is: Radix Notoginseng 88g, Flos Carthami 27g, Radix Angelicae Sinensis 17.5g, Rhizoma Chuanxiong 21g, Radix Angelicae Dahuricae 17g and Eupolyphaga Seu Steleophaga 27g, and its preparation method comprises the following steps:
(1) weighting raw materials in proportion, mixes after pulverizing;
(2) in crude drug, add the distilled water of 6 times of weight, and add cathepsin and cellulase (2:1) 20g, keep 60 degrees Celsius of temperature, carry out enzymolysis processing 1.5 hours;
(3) by the mixture boiled after enzymolysis 10 minutes, make, after enzyme-deactivating, to be cooled to room temperature, isolate filtrate 1 and filtering residue 1;
(4) get filtrate 1, be evaporated to 1/3rd, centrifugal, obtain extracting solution 1;
(5) get filtering residue 1, add 75% ethanol-n-butyl alcohol (2:1) mixed solution, with alkali adjusting pH to 9, reflux, extract, 4 hours, separates and obtains filtrate 2 and filtering residue 2;
(6) merge extractive liquid, 1 and filtrate 2, add 0.1% active carbon by weight, filters, and being concentrated into relative density is 1.05-1.12, obtains concentrated solution; Further be concentrated into thick paste shape;
(7) add appropriate Pulvis Talci, low-substituted hydroxypropyl cellulose and correctives, mix homogeneously, through soft material processed, granulation, dry, tabletting, to obtain final product,, every containing the crude drug extract that is equivalent to mercurochrome tablet crude drug crude drug 0.26g.
Claims (9)
1. one kind has the mercurochrome tablet of promoting blood circulation and stopping pain effect, it is characterized in that its crude drug is: Radix Notoginseng 80-90g, Flos Carthami 20-30g, Radix Angelicae Sinensis 15-25g, Rhizoma Chuanxiong 15-25g, Radix Angelicae Dahuricae 15-25g and Eupolyphaga Seu Steleophaga 20-30g, every containing the crude drug extract being equivalent to more than mercurochrome tablet crude drug crude drug 0.25g.
2. mercurochrome tablet according to claim 1, is characterized in that its crude drug more preferably: Radix Notoginseng 83-88g, Flos Carthami 25-30, Radix Angelicae Sinensis 15-20, Rhizoma Chuanxiong 20-25g, Radix Angelicae Dahuricae 15-20g and Eupolyphaga Seu Steleophaga 25-30g.
3. mercurochrome tablet according to claim 2, is characterized in that its crude drug more preferably: Radix Notoginseng 85-88g, Flos Carthami 25-28g, Radix Angelicae Sinensis 17-20g, Rhizoma Chuanxiong 21-24g, Radix Angelicae Dahuricae 17-20g and Eupolyphaga Seu Steleophaga 25-28g.
4. mercurochrome tablet according to claim 3, is characterized in that its crude drug more preferably: Radix Notoginseng 85.8g, Flos Carthami 26.6g, Radix Angelicae Sinensis 19.2g, Rhizoma Chuanxiong 23.6g, Radix Angelicae Dahuricae 19.2g and Eupolyphaga Seu Steleophaga 26.6g.
5. mercurochrome tablet according to claim 3, is characterized in that its crude drug more preferably: Radix Notoginseng 88g, Flos Carthami 27g, Radix Angelicae Sinensis 17.5g, Rhizoma Chuanxiong 21g, Radix Angelicae Dahuricae 17g and Eupolyphaga Seu Steleophaga 27g.
6. the preparation method of the mercurochrome tablet of claim 1-5 any one, is characterized in that comprising the following steps:
(1) weighting raw materials in proportion, mixes after pulverizing;
(2) in crude drug, add the distilled water of 6-8 times of weight, and add enzyme, keep temperature 40-60 degree Celsius, carry out enzymolysis processing 1-3 hour;
(3) by the mixture boiled after enzymolysis 10 minutes, make, after enzyme-deactivating, to be cooled to room temperature, isolate filtrate 1 and filtering residue 1;
(4) get filtrate 1, be evaporated to 1/3rd, centrifugal, obtain extracting solution 1;
(5) get filtering residue 1, add 75% ethanol-n-butyl alcohol mixed solution, be adjusted to pH=7-9 with alkali, reflux, extract, 2-5 hour, separates and obtains filtrate 2 and filtering residue 2;
(6) merge extractive liquid, 1 and filtrate 2, add 0.1% active carbon by weight, filters, and being concentrated into relative density is 1.05-1.12, obtains concentrated solution; Further be concentrated into thick paste shape;
(7) add appropriate filler, disintegrating agent, correctives, mix homogeneously, makes tablet through soft material processed, granulation, dry, tablet forming technique, and every containing the crude drug extract being equivalent to more than mercurochrome tablet crude drug crude drug 0.25g.
7. preparation method according to claim 6, it is characterized in that in step (2), enzyme is selected from trypsin, cathepsin, pepsin, cellulase or its compositions, preferably the compound enzyme of trypsin and cellulase 2:1 or cathepsin and cellulase 2:1.
8. according to the preparation method described in claim 6 or 7, it is characterized in that, in step (5), 75% ethanol-n-butyl alcohol mixed solution refers to the mixed solution of 75% ethanol-n-butyl alcohol (3:1).
9. according to the preparation method described in claim 6-8 any one, it is characterized in that, in step (7), filler is selected from dextrin, Pulvis Talci, microcrystalline Cellulose or its mixture, the most preferably compositions of Pulvis Talci and microcrystalline Cellulose 1:1; Disintegrating agent is selected from carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, most preferably low-substituted hydroxypropyl cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410354780.XA CN104116771B (en) | 2014-07-24 | A kind of mercurochrome tablet with promoting blood circulation and stopping pain effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410354780.XA CN104116771B (en) | 2014-07-24 | A kind of mercurochrome tablet with promoting blood circulation and stopping pain effect and preparation method thereof |
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| Publication Number | Publication Date |
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| CN104116771A true CN104116771A (en) | 2014-10-29 |
| CN104116771B CN104116771B (en) | 2017-01-04 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114668826A (en) * | 2022-03-31 | 2022-06-28 | 赣州佰珍堂香料有限公司 | Blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114668826A (en) * | 2022-03-31 | 2022-06-28 | 赣州佰珍堂香料有限公司 | Blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and preparation method thereof |
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