CN1814072A - Xiegan-anshen oral-preparation preparing method and preparation thereof - Google Patents
Xiegan-anshen oral-preparation preparing method and preparation thereof Download PDFInfo
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Abstract
The invention discloses a method for preparing xiegan anshen oral preparation and the oral preparation, and its characters lie in dividing raw materials into three groups, respectively crushing or extractive refining according to process conditions of research, combining the made intermediate products, and adding in pharmaceutically acceptable auxiliary materials or not to make different preparation treatments so as to make different oral solid or liquid preparations. It can be made into xiegan anshen pills with small dosage and good curative effect and is suitable to be made into multiple oral solid and liquid preparations such as tablets, capsules, mixtures, etc., reducing dosage, improving curative effect and providing more forms of prepared drugs for clinic patients to select.
Description
Technical field
The present invention relates to a kind of method for preparing Chinese patent medicine, and the preparation of making in this way, relate in particular to a kind of eliminating pathogen in the liver the calm the nerves method of oral formulations and oral formulations of making in this way of preparing.
Background technology
The eliminating pathogen in the liver Anshen Wan is a kind of comparatively widely Chinese patent medicine of clinical use, by 9 parts of Radix Gentianae, 9 parts of Radix Scutellariaes, 9 parts of Fructus Gardeniaes (Rhizoma Zingiberis Recens is processed), 60 parts of Concha Margaritiferas, 15 parts of Concha Ostreaes, 15 parts of Os Draconis, 9 parts of Semen Platycladi, 15 parts of Semen Ziziphi Spinosaes (stir-fry), 9 parts of Radix Polygalaes (going do willingly grass to process), 9 parts of Radix Angelicae Sinensis, 9 parts of Radix Rehmanniae, 9 parts of Radix Ophiopogonis, 9 parts of Fructus Tribulis (deburring salt is processed), 9 parts in Poria, 9 parts of Semen Plantaginiss (salt is processed), 9 parts of Rhizoma Alismatis (salt is processed), 3 parts in Radix Glycyrrhizae is through being ground into fine powder, sieve, mixing, use water pill, make after the drying, once oral 6g, 2 times on the one, have purging liver-fire, the effect of tranquillization with heavy prescription is used for the treatment of insomnia, vexed, palpitation with fear and neurasthenia.The drug standard of eliminating pathogen in the liver Anshen Wan records in the 4th 92 pages of Drug Standard of Ministry of Public Health of the Peoples Republic of Chinas (Chinese traditional patent formulation preparation) (documents 1).
But the weak point of said preparation and drug standard thereof is that its preparation method is more original, simply, coarse, what adopt is the method that raw material of Chinese medicine is directly beaten the general one-tenth ball of water behind the powder, not refining through the extraction of effective ingredient, thereby dose is big, curative effect is relatively poor, act on slower, be not easy to carry, and be not suitable for adopting preparation technique more advanced on the pharmaceutics and add on the pharmaceutics acceptable adjuvant that to make dose little, be easy to carry, better efficacy, act on various modern dosage form such as tablet faster, capsule, mixture etc. have limited such medicine range of application clinically.Its another weak point is, according to the nature difference of each raw material components, does not adopt different extraction process for purification, thereby has also influenced the quality of preparation.
Summary of the invention
An object of the present invention is to provide a kind of extraction that is different from existing method, refining, preparation method, thereby produce that dose is less, better efficacy, act on medicine faster.
Another object of the present invention is with the rational preparation technology and the technological parameter that find out, the multiple eliminating pathogen in the liver of the producing different dosage form oral formulations of calming the nerves, the tablet of calming the nerves as eliminating pathogen in the liver, capsule, mixture etc.
Prove through experimental study, extract in the lump as flavour of a drug above-mentioned full side, gained extractum is more and than thickness, be difficult to preparations shaping, and flavour of a drug such as Poria soak the chronic of the heart when decocting, and flavour of a drug such as Radix Gentianae, Radix Scutellariae soak the active constituent content that extracts the back for a long time and descend, and flavour of a drug such as Concha Margaritifera, Concha Ostreae, Os Draconis need decoct the long time and should not handle with alcohol, as feed intake easy " quick-fried spattering " and filtration difficulty during decoction with medicated powder.So the present invention adopts prepares the calm the nerves method of oral formulations of eliminating pathogen in the liver and is:
Raw material components is divided into three groups to be pulverized respectively or extract refining: Poria, Rhizoma Alismatis are one group, pulverize or soak, extract refining; Concha Margaritifera, Concha Ostreae, Os Draconis are one group, and extracting in water is refining; Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae are one group, and extracting in water is refining; The prepared intermediate products of three groups of raw material components merge, and do not add or add on the pharmaceutics acceptable adjuvant and carry out different preparation processing, make different oral formulations.
According to the different preparation processing modes and the needs of dosage form, can not add adjuvant when adopting preparation method of the present invention, also can add acceptable auxiliary on the various pharmaceuticss, as disintegrating agent, lubricant, binding agent, cosolvent, thickening agent, antiseptic etc., and be prepared into acceptable multiple pharmaceutical dosage form on the pharmaceutics with the modern Chinese medicine formulation method.Medicated powder after for example Poria, Rhizoma Alismatis can being pulverized mixes with Concha Margaritifera, Concha Ostreae, the purified extractum of Os Draconis extracting in water and Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, the purified extractum of Radix Glycyrrhizae extracting in water, crushed after being dried is made pill, powder, capsule, medicinal tea, oral suspensions respectively; Medicated powder after also Poria, Rhizoma Alismatis can being pulverized mixes with Concha Margaritifera, Concha Ostreae, the purified extractum of Os Draconis extracting in water and Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, the purified extractum of Radix Glycyrrhizae extracting in water, not adding or add suitable adjuvant granulates, tabletting or pack or encapsulated promptly can be made into tablet or granule or capsule; Also can be with the extractum of three groups of raw material components extracting in waters through precipitate with ethanol or precipitate with ethanol and handling accordingly not, add preparation different solid preparation or the required different auxiliary material of liquid preparation, promptly can be made into multi-form oral liquids such as multi-form oral solid formulation such as capsule, tablet, pill, powder, drop pill, granule or mixture, soft extract, syrup.
Preparation method and the process conditions determined through experimental study are: Poria, Rhizoma Alismatis powder are broken into fine powder or fine powder, sieve, or add 8 times of water gagings immersion decoctions after 1～12 hour for the first time, second and third time adds 6 times of water gagings and decocts, each 1 hour, be concentrated into an amount of after decoction liquor merges; The decocting that adds 4～8 times of amounts after Concha Margaritifera, Concha Ostreae, Os Draconis are pulverized boils 3～5 times, each 1～3 hour, is concentrated into an amount of after decoction liquor merges; Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae add 6～10 times of water gagings and decoct 2～4 times, each 0.5～2 hour, are concentrated into an amount of after decoction liquor merges.
The preferred processing condition of said method is: Poria, Rhizoma Alismatis powder are broken into fine powder, cross 100 mesh sieves, and with its double as adjuvant; Concha Margaritifera, Concha Ostreae, Os Draconis Powder are broken into the coarse granule of 2mm～10mm, and the decocting that adds 6 times of amounts boils 4 times, each 2 hours, are concentrated into an amount of after decoction liquor merges; Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae add 8 times of water gagings for the first time, the boiling water decoction that feeds intake, second and third time adds 6 times of water gagings and decocts, and each 1 hour, is evaporated to an amount of after decoction liquor merges.
In order further to reduce the impurity of intermediate product, reduce the dose of made preparation and adapt to the particularly requirement of liquid preparation of some preparation, can select Poria, water decoction of Rhizoma Alismatis (as not being the words that adopt the method for pulverizing) and Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, one group or two groups in these two groups of water decoctions of the water decoction of Radix Glycyrrhizae is condensed into the clear paste that relative density is 1.05～1.15 (60 ℃), add ethanol and make that to contain the alcohol amount be 50%～80%, stir evenly, leave standstill after-filtration, be concentrated into an amount of behind the filtrate recycling ethanol.
The preferred processing condition of above-mentioned precipitate with ethanol is: it is the clear paste of 1.09～1.11 (60 ℃) that the water decoction concentrating under reduced pressure becomes relative density, adds ethanol and makes that to contain the alcohol amount be 70%, stirs evenly, and leaves standstill 24 hours after-filtration, is concentrated into an amount of behind the filtrate recycling ethanol.
Adopt above-mentioned preparation method not only can make dose still less, the eliminating pathogen in the liver Anshen Wan of better efficacy, also be more suitable for making various oral solid formulations and oral liquids such as tablet, capsule, mixture, for clinical patients provides more dosage form selection.
The result of pharmacological testing and clinical research proves: the eliminating pathogen in the liver of adopting above-mentioned preparation method the to make oral formulations of calming the nerves not only has the function of purging liver-fire, tranquillization with heavy prescription, can be used for Cure for insomnia, vexed, palpitation with fear and neurasthenia, also had better tranquilizing soporific, anti-central nervous excitation, resisting hypertension, effect such as analgesic, can be used for the treatment of pathogenic fire derived from stagnation of liver-QI card syndromes such as insomnia, susceptible to lose temper due to restlessness, palpitation with fear, neurasthenia and thirst and liking drink, conjunctival congestion, bitter taste, big constipation better, and not have tangible untoward reaction.
The specific embodiment
Come further to set forth the preparation method of medicine of the present invention and the preparation of making thereof by the following examples, these embodiment have comprised toxicity test, pharmacodynamics test and the clinical efficacy result of the test of medicine of the present invention.But this should be interpreted as that scope of the present invention only limits to following embodiment, every technology that realizes based on foregoing of the present invention all belongs to the scope of protection of present invention.
Embodiment 1: the preparation tablets of medicine of the present invention
Get Radix Gentianae 62.5g, Concha Margaritifera 416.7g, Radix Scutellariae 62.5g, Fructus Gardeniae (Rhizoma Zingiberis Recens is processed) 62.5g, Fructus Tribuli (deburring salt is processed) 62.5g, Concha Ostreae 104.2g, Os Draconis 104.2g, Poria 62.5g, Semen Plantaginis (salt is processed) 62.5g, Rhizoma Alismatis (salt is processed) 62.5g, Semen Ziziphi Spinosae (stir-fry) 104.2g, Semen Platycladi 62.5g, Radix Polygalae (going do willingly grass to process) 62.5g, Radix Rehmanniae 62.5g, Radix Ophiopogonis 62.5g, Radix Angelicae Sinensis 62.5g, Radix Glycyrrhizae 20.8g, Poria wherein, Rhizoma Alismatis adds 8 times of water gagings and decocts 3 times (soaking first 8 hours), each 1.5 hours, being concentrated into relative density after decoction liquor merges was 1.20 (80 ℃); Concha Margaritifera, Concha Ostreae, Os Draconis add 5 times of water gagings and decoct 3 times, each 3 hours, are concentrated into inventory (g) after decoction liquor merges: medicine liquid volume (ml)=10: 1; Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae add 8 times of water gagings and decoct 2 times, and each 1.5 hours, being concentrated into relative density after decoction liquor merges was 1.20 (80 ℃); Three groups of extractum merge, and make bed material in right amount with starch, and spray adds extractum and carries out one-step palletizing, and granulate is pressed into 1000, every 0.5g, and coating, promptly.Once oral 4,2 times on the one.
Embodiment 2: the capsule preparation of medicine of the present invention
Get Radix Gentianae 83.3g, Concha Margaritifera 555.6g, Radix Scutellariae 83.3g, Fructus Gardeniae (Rhizoma Zingiberis Recens is processed) 83.3g, Fructus Tribuli (deburring salt is processed) 83.3g, Concha Ostreae 138.9g, Os Draconis 138.9g, Poria 83.3g, Semen Plantaginis (salt is processed) 83.3g, Rhizoma Alismatis (salt is processed) 83.3g, Semen Ziziphi Spinosae (stir-fry) 138.9g, Semen Platycladi 83.3g, Radix Polygalae (going do willingly grass to process) 83.3g, Radix Rehmanniae 83.3g, Radix Ophiopogonis 83.3g, Radix Angelicae Sinensis 83.3g, Radix Glycyrrhizae 27.8g, wherein Poria, Rhizoma Alismatis powder are broken into fine powder, cross 100 mesh sieves; Concha Margaritifera, Concha Ostreae, Os Draconis add 7 times of water gagings and decoct 3 times, each 3 hours, are concentrated into inventory (g) after decoction liquor merges: medicine liquid volume (ml)=8: 1; Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae add 8 times of water gagings and decoct 2 times, each 1.5 hours, being concentrated into relative density after decoction liquor merges was 1.20 (80 ℃), extracted concentrated solutions with three flavors such as above-mentioned Concha Margaritifera and merged, mix with above-mentioned fine powder again, drying is pulverized, and crosses 80 mesh sieves, mixing, incapsulate, make 1000, promptly.Once oral 3,2 times on the one.
Embodiment 3: the mixture preparation of medicine of the present invention
Get Radix Gentianae 25g, Concha Margaritifera 166.7g, Radix Scutellariae 25g, Fructus Gardeniae (Rhizoma Zingiberis Recens is processed) 25g, Fructus Tribuli (deburring salt is processed) 25g, Concha Ostreae 41.7g, Os Draconis 41.7g, Poria 25g, Semen Plantaginis (salt is processed) 25g, Rhizoma Alismatis (salt is processed) 25g, Semen Ziziphi Spinosae (stir-fry) 41.7g, Semen Platycladi 25g, Radix Polygalae (going do willingly grass to process) 25g, Radix Rehmanniae 25g, Radix Ophiopogonis 25g, Radix Angelicae Sinensis 25g, Radix Glycyrrhizae 8.3g, wherein Poria, Rhizoma Alismatis add 8 times of water gagings immersion decoctions after 10 hours for the first time, second and third time adds 6 times of water gagings and decocts, each 1 hour, be concentrated into relative density after decoction liquor merges and be about 1.10 (60 ℃); Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae add 8,6,6 times of water gagings and decoct 3 times, each 1 hour, boiling water feeds intake for the first time, be concentrated into relative density after decoction liquor merges and be about 1.10 (60 ℃), add ethanol and make that to contain the alcohol amount be 70%, stir evenly, leave standstill after-filtration, be concentrated into 1.25 (80 ℃) behind the filtrate recycling ethanol; Concha Margaritifera, Concha Ostreae, Os Draconis Powder are broken into the coarse granule of 2mm～10mm, add 6 times of water gagings and decoct 4 times, each 2 hours, are concentrated into inventory (g) after decoction liquor merges: medicine liquid volume (ml)=12: 1; Three groups of extractum merge, and mixing is centrifugal, gets supernatant, adds cyclamate 0.4g, sorbic acid 2g, and polysorbate 80 9g adds water to 1000ml, filters, fill, sterilization, promptly.Once oral 10ml, 2 times on the one.
Toxicity test:
Animal experiment proves, the eliminating pathogen in the liver of the present invention oral formulations of calming the nerves is 240g crude drug/kg every day to the maximum tolerated dose of mouse stomach, 1200 times of the clinical consumption per day that is equivalent to be grown up; Press 100 times and 25 times of adult's clinical dosage and give 6 weeks of rat continuous irrigation stomach, every physiology of animal, biochemistry, routine blood test, organs and tissues morphology etc. show no obvious abnormalities.
Pharmacodynamics test:
Pharmacodynamics test proves, eliminating pathogen in the liver of the present invention calms the nerves that oral formulations has the spontaneous activity that suppresses mice, improves animal sleep, antagonism central nervous excitation, resisting hypertension, effect (being p＜0.01 or p＜0.05) such as analgesic, with the eliminating pathogen in the liver Anshen Wan comparison no significant difference (p＞0.05) of the documents 1 that contains equal crude drug dosage.
Clinical research:
Clinical at random, the double blinding dual analog, parallel group the test in, selection meets the insomnia diagnostic criteria, meets the patient of pathogenic fire derived from stagnation of liver-QI card diagnostic criteria, each 36 example of test group and matched group, two groups sex, age, severity extent, course of disease distribution, cardinal symptom, syndrome integration, each index of Pittsburgh etc. are no significant difference (p＞0.05) all.Test group and matched group patient take 3 eliminating pathogen in the liver Anshen Wan 6g that produce by documents 1 with Beijing group of Tongrentang of eliminating pathogen in the liver ANSHEN JIAONANG of the present invention respectively, 2 times on the 1st, take medicine continuously for 2 weeks.
The result is to the curative effect of insomnia, and the cure rate of test group is 22.22%, and cure-remarkable-effectiveness rate is 38.89%, and total effective rate is 83.33%, and matched group is respectively 20.00%, 34.29%, 68.57%, two group difference does not have significance (p＞0.05); To the curative effect of pathogenic fire derived from stagnation of liver-QI card syndrome, the cure rate of test group is 11.11%, and cure-remarkable-effectiveness rate is 55.56%, and total effective rate is 86.11%, and matched group is respectively 8.57%, 31.43%, 77.14%, two group difference does not have the difference of showing property (p＞0.05); But in the keeping the score of symptom and signs such as insomnia after treatment, susceptible to lose temper due to restlessness, palpitation with fear, thirst and liking drink, bitter taste, conjunctival congestion, big constipation, test group is better than matched group (p＜0.01) to the effect of palpitation with fear, the sleep therapy curative effect relatively in, the time for falling asleep of test is than the short (p＜0.05=of matched group.Do not observe eliminating pathogen in the liver mind-tranquilizing formulation of the present invention in the test untoward reaction is arranged.
Above presentation of results, owing to each component in the eliminating pathogen in the liver mind-tranquilizing formulation being divided into groups and having adopted different extraction process for purification according to its characteristic, the result with the identical situation of the crude drug amount of taking of the eliminating pathogen in the liver Anshen Wan of documents 1 under, made medicine of the present invention has reduced dose, and has unexpectedly improved curative effect.The eliminating pathogen in the liver of adopting preparation method of the present invention the to make oral formulations of calming the nerves not only has the identical treatment effect of the eliminating pathogen in the liver Anshen Wan of documents 1, also palpitation with fear and difficulty falling asleep there is better therapeutic, improved quality, reduced consumption, also for the patient provides multiple different dosage form, needs have clinically been satisfied simultaneously.
Claims (10)
1. one kind prepares the calm the nerves method of oral formulations of the eliminating pathogen in the liver that contains 9 parts of Radix Gentianae, 9 parts of Radix Scutellariaes, 9 parts of Fructus Gardeniaes (Rhizoma Zingiberis Recens is processed), 60 parts of Concha Margaritiferas, 15 parts of Concha Ostreaes, 15 parts of Os Draconis, 9 parts of Semen Platycladi, 15 parts of Semen Ziziphi Spinosaes (stir-fry), 9 parts of Radix Polygalaes (going do willingly grass to process), 9 parts of Radix Angelicae Sinensis, 9 parts of Radix Rehmanniae, 9 parts of Radix Ophiopogonis, 9 parts of Fructus Tribulis (deburring salt is processed), 9 parts in Poria, 9 parts of Semen Plantaginiss (salt is processed), 9 parts of Rhizoma Alismatis (salt is processed), 3 parts in Radix Glycyrrhizae, and it is characterized in that raw material components is divided into three groups to be pulverized respectively or extract refining: Poria, Rhizoma Alismatis are pulverized or soak, extract refining; Concha Margaritifera, Concha Ostreae, Os Draconis extracting in water are made with extra care; Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae extracting in water are made with extra care; The prepared intermediate products of three groups of raw material components merge, and do not add or add on the pharmaceutics acceptable adjuvant and carry out different preparation processing, make different oral administration solids or liquid preparation.
2. preparation method according to claim 1 is characterized in that: Poria, Rhizoma Alismatis powder are broken into fine powder or fine powder, sieve; Or adding 8 times of water gagings immersion decoctions after 1～12 hour for the first time, second and third time adds 6 times of water gagings and decocts, and each 1 hour, is concentrated into an amount of after decoction liquor merges.
3. preparation method according to claim 1 and 2 is characterized in that: Poria, Rhizoma Alismatis powder are broken into fine powder, cross 100 mesh sieves, and with its double as adjuvant.
4. preparation method according to claim 1 is characterized in that: the decocting that adds 4～8 times of amounts after Concha Margaritifera, Concha Ostreae, Os Draconis are pulverized boils 3～5 times, each 1～3 hour, is concentrated into an amount of after decoction liquor merges.
5. according to claim 1 or 4 described preparation methoies, it is characterized in that: Concha Margaritifera, Concha Ostreae, Os Draconis Powder are broken into the coarse granule of 2mm～10mm, and the decocting that adds 6 times of amounts boils 4 times, each 2 hours, are concentrated into an amount of after decoction liquor merges.
6. preparation method according to claim 1, it is characterized in that: Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae add 6～10 times of water gagings and decoct 2～4 times, each 0.5～2 hour, be concentrated into an amount of after decoction liquor merges.
7. preparation method according to claim 6, it is characterized in that: Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae add 8 times of water gagings for the first time, the boiling water decoction that feeds intake, second and third time adds 6 times of water gagings and decocts, each 1 hour, be evaporated to an amount of after decoction liquor merges.
8. according to claim 1,2,6 or 7 described preparation methoies, it is characterized in that: one group or two groups in these two groups of water decoctions of the water decoction of water decoction of Poria, Rhizoma Alismatis and Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae is condensed into the clear paste that relative density is 1.05～1.15 (60 ℃), add ethanol and make that to contain the alcohol amount be 50%～80%, stir evenly, leave standstill after-filtration, be concentrated into an amount of behind the filtrate recycling ethanol.
9. preparation method according to claim 8, it is characterized in that: it is the clear paste of 1.09～1.11 (60 ℃) that in these two groups of water decoctions of the water decoction of water decoction of Poria, Rhizoma Alismatis and Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Semen Platycladi, Semen Ziziphi Spinosae, Radix Polygalae, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Fructus Tribuli, Semen Plantaginis, Radix Glycyrrhizae one group or two groups of concentrating under reduced pressure become relative density, add ethanol and make that to contain the alcohol amount be 70%, stir evenly, leave standstill 24 hours after-filtration, be concentrated into an amount of behind the filtrate recycling ethanol.
10. adopt the eliminating pathogen in the liver of the described method preparation of claim 1～9 oral formulations of calming the nerves, it is characterized in that these preparations comprise tablet, capsule, granule, pill, powder, medicinal tea, mixture, syrup, soft extract, oral suspensions, drop pill.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491625B (en) * | 2009-02-11 | 2011-05-25 | 陆小左 | Sedative anti-insomnia oral medicine |
| US7968128B2 (en) | 2008-11-03 | 2011-06-28 | Viva Pharmaceutical Inc. | Plant extract compositions for affecting sleep |
| CN102697995A (en) * | 2012-06-20 | 2012-10-03 | 李良 | Gentian Chinese medicinal decoction for relieving insomnia and preparation method of gentian Chinese medicinal decoction |
| CN102698094A (en) * | 2012-06-18 | 2012-10-03 | 田冬梅 | Medicament for treating female depression |
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2005
- 2005-12-06 CN CNB2005100222313A patent/CN100518781C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7968128B2 (en) | 2008-11-03 | 2011-06-28 | Viva Pharmaceutical Inc. | Plant extract compositions for affecting sleep |
| CN101491625B (en) * | 2009-02-11 | 2011-05-25 | 陆小左 | Sedative anti-insomnia oral medicine |
| CN102698094A (en) * | 2012-06-18 | 2012-10-03 | 田冬梅 | Medicament for treating female depression |
| CN102697995A (en) * | 2012-06-20 | 2012-10-03 | 李良 | Gentian Chinese medicinal decoction for relieving insomnia and preparation method of gentian Chinese medicinal decoction |
| CN102697995B (en) * | 2012-06-20 | 2014-04-16 | 李良 | Gentian Chinese medicinal decoction for relieving insomnia and preparation method of gentian Chinese medicinal decoction |
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| CN100518781C (en) | 2009-07-29 |
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