CN101062130A - Yang recuperating decoction soft capsule preparing method - Google Patents
Yang recuperating decoction soft capsule preparing method Download PDFInfo
- Publication number
- CN101062130A CN101062130A CNA2006100100109A CN200610010010A CN101062130A CN 101062130 A CN101062130 A CN 101062130A CN A2006100100109 A CNA2006100100109 A CN A2006100100109A CN 200610010010 A CN200610010010 A CN 200610010010A CN 101062130 A CN101062130 A CN 101062130A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- capsule
- yang
- oil
- decoction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparing method of yang-tonifying back five soup soft capsule, which comprises the following steps: putting astragalus root, chiretta rear, red peony root, sleeper, Ligusticum wallichii, peach kernel and safflower into traditional medicine extracting tank; adding into water; boiling for three times; collecting benzine; merging water boiling liquor extract; centrifuging; filtering; decompressing for filter liquor; condensing; spray-drying; grinding to 120 order; dissolving the benzine into edible oil; mixing with dried concreting powder; counting 30-40% of oil group quality in soft capsule with the dried concreting powder; grinding the mixture with colloid grinding isotrope; adding into dope of brown pigment as capsule material; producing capsule core concrete oil host liquid; stirring; fluid-pressing the capsule core concrete oil host; drying; washing ball; drying; getting the product. This product can be used to replace yang-tonifying back five soup.
Description
Technical field:
The present invention relates to a kind of BUYANG HUANWU TANG be made the preparation of soft capsule method.
Background technology:
Apoplexy is the general designation of the traditional Chinese medical science to cerebrovascular disease, comprises diseases such as cerebral hemorrhage and cerebral infarction.The sickness rate of apoplexy, mortality rate and disability rate are all quite high, are the diseases of a class serious harm human health.In China, its sickness rate is annual per 100,000 populations, 185～219 examples.Sickness rate is with age growth, and about 72% apoplexy first occurs in the old people of over-65s.Prevalence has 429～620 examples approximately in per 100,000 populations.Prevention and treatment apoplexy cause international the attention, particularly for apoplexy patient rehabilitation, also do not have very effective good medicine and Therapeutic Method at present.Our national traditional Chinese traditional treatment apoplexy with a long history accumulated very valuable experience.
" BUYANG HUANWU TANG " recorded the earliest in traditional Chinese medical science ancient books " correction of the errors of medical works ", and by Qing Dynasty's well-known doctor's Wang Qingren is created, former side forms (Radix Astragali 120 grams, Radix Angelicae Sinensis 6 grams, Radix Paeoniae Rubra 4.5 grams, Pheretima 3 grams, Rhizoma Chuanxiong 3 grams, Semen Persicae 3 grams, Flos Carthami 3 grams) by 7 flavor medicines.Being mainly used in the apoplexy of " because of void causes the stasis of blood ", is the representative prescription of benefiting QI for activating blood circulation, dredging the meridian.Came out more than 300 year, and praised highly by traditional Chinese medical science famous expert, clinical and treatment main formula that each traditional Chinese medical science name daily life of a family adopts, and adopt this basis and go up and increase and decrease improvement at disease, the clinical effectiveness highly significant is subjected to domestic and international favorable comment deeply.Not only effective to apoplexy, modern medicine shows that BUYANG HUANWU TANG is removed reducing blood viscosity, reduces platelet aggregation, improves hemorheological index, improves cerebral blood supply and microcirculation, and promotes the metabolism of brain cell, helps the reparation of brain tissue impairment.Clinical effectiveness shows that also this side causes various dysfunction effect highly significants to improving cerebral hemorrhage and cerebral thrombosis.Japan is many to BUYANG HUANWU TANG research and clinical practice.China Taiwan is used also relatively wider to BUYANG HUANWU TANG.China is at the eighties initial stage, by Beijing Changcheng Pharmaceutical Factory the prescription of BUYANG HUANWU TANG has been carried out improving (Radix Astragali 60g Radix Angelicae Sinensis 6g Radix Paeoniae Rubra 6g Pheretima 3g Rhizoma Chuanxiong 3g Semen Persicae 3g Flos Carthami 3g), develop " embolism extinguishing oral liquid-YANG invigorating is five oral liquids also ", cause clinical widely attention, the whole nation has 20 many enterprises to fall over each other to produce, but because the production technology disunity, the quality standard imperfection has influenced quality and clinical effectiveness.Owing to change oral liquid or dissolved granule into, mass efficient composition in original decoction agent is lost, owing to concentrate and improve clarity, increased precipitate with ethanol in the technology and caused loss of active ingredients with the filtration operation, particularly for having causing resuscitation with aromatic drugs in the medical materials such as Radix Angelicae Sinensis, Flos Carthami, Radix Paeoniae Rubra, the effective stearopten of activating blood circulation to dissipate blood stasis is difficult to keep, and therefore directly has influence on curative effect.This also is the basic reason that BUYANG HUANWU TANG novel form curative effect is inferior to former decoction agent.
Summary of the invention:
The purpose of this invention is to provide the preparation method that a kind of Qing Dynasty treatment by Chinese herbs apoplexy name side " BUYANG HUANWU TANG " is prepared into the Yang recuperating decoction soft capsule of modern Chinese medicine novel form " soft capsule ".
Above-mentioned purpose realizes by following technical scheme:
A kind of preparation method of Yang recuperating decoction soft capsule, it comprises: at first by weight with 120 parts of Radix Astragali, and 6 parts of Radix Angelicae Sinensis, 4.5 parts of Radix Paeoniae Rubra, 3 parts of Pheretimas, 3 parts of Rhizoma Chuanxiongs, 3 parts in Semen Persicae, 3 parts of Chinese crude drugs of Flos Carthami, put into the Chinese medicine extraction jar, decoct with water three times, 1-2 hour for the first time, be respectively for the second time, for the third time 1-1.5 hour; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; Filtrate is evaporated to relative density under 60-80 ℃ be 1.05-1.10, then its spray drying become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for the 30-40% of oil matrix amount in the soft capsule, then mixture is carried out homogenizing with colloid mill and grinds; Make capsule-core concrete oil substrate liquid with the gelatin that adds brown pigment as the capsule material, under 70-80 ℃ of stirring condition, capsule-core concrete oil substrate hydraulic pressure is made soft capsule; Drying, wash ball, drying makes soft capsule.
This technical scheme has following beneficial effect:
1. prove through technical study: this technology of the present invention is followed original BUYANG HUANWU TANG decocting process fully, kept original technology curative effect to greatest extent, pass through collection in addition, and add to scientifically and rationally in the soft capsule, make effective ingredient more complete volatile oil in the leaching process.
The art of this patent adopts the original BUYANG HUANWU TANG prescription of Qing Dynasty's Wang Qingren, keep the curative effect characteristic that it decocts agent, adopt modern state-of-the-art Chinese medicinal soft capsule dosage form and technology, because production process does not relate to the clarity problem, the functional component that has kept original decoction as much as possible, and whole volatile oil that will extract are dissolved in oleaginous base, with the extraction extractum emulsifying of other drug, are contained within the opaque capsule material of soft capsule.Make effective ingredient reasonable fully, covered the abnormal smells from the patient of Chinese medicine, made things convenient for the patient.Because seeing through of secluding air and light increased stability of drug, guaranteed curative effect.Reduced extraction process, reduced cost, increased economic efficiency, soft capsule dosage form is modern medicine novel form in addition, has improved the medicine quality, thoroughly improved Chinese medicine ill-looking decoct trouble drawback, created may for tcm product goes to the world.
2. the soft capsule of this Technology preparation is compared with oral liquid, hard capsule after the improvement with former decoction agent, and not only taking convenience has completely cut off extraneous factor (light, wet, heat) influence, and quality stability is improved.But also by external quality, changed the ill-looking drawback of Chinese medicine, be that the quality of Chinese medicine is improved and becomes possibility for going to the world.
3. the Yang recuperating decoction soft capsule produced of this Technology advances pharmacology and toxicological experiment shows: be the medicine that a kind of toxicity is low, body do not had any obvious toxic-side effects.Experimentation is as follows:
(1) acute toxicity test:
Its mouse oral median lethal dose(LD 50) (LD
50) mensuration: get 50 of kunming mouses, body weight 1822g/ only is divided into 5 groups, 10 every group at random.Before the test behind the fasting 10h, with YANG invigorating five kinds of flaccidity in infant soup capsule capsule herb liquid 1 time/day also, per os gavages, and each organizes dosage respectively 1.000,2.150,4.620,9.940,21.370mg (crude drug amount)/kg.Observed for 1 week poisoning symptom and the death condition of record animal after the administration.Calculate LD according to the animal dead situation
50
The mensuration of 1 time on the 1st maximum tolerated dose (MTD): get 20 of kunming mouses, body weight 1822g/ only.Can irritate the Cmax (crude drug 1g/mL) of stomach and 1 gastric infusion of maximum volume (0.05mL/g) that mice is tolerated with Yang recuperating decoction soft capsule capsule herb liquid.After this observe 7d continuously, allow mice ad lib and drinking-water during this.
(2) subacute toxicity test test method:
60 of female Wistar rat, body weight 120150g/ only, raise 5d in advance after, be divided into 4 groups at random, 15 every group.The I group is matched group, II, and III, the IV group is the medication group.The medication group is respectively with 1/10MTD, and the dosage of 1/3MTD and MTD gavages, successive administration 60d; Matched group gives the purified water of same dose.
Detect index: observe every day, write down the mental status, feed activity and the defecation situation of animal, weigh weekly 1 time.Before administration and after the off-test, in the rat tails blood sampling, whole blood is made blood routine examination, and serum is made biochemical indicator and detected.After the off-test, dissect animal, the pathological changes of internal organs is respectively organized in perusal; Take by weighing the weight in wet base of main organs (heart, liver, spleen, lungs, kidney), and calculate the organ coefficient (organ coefficient=internal organs weight in wet base/body weight * 100) of each internal organs.
Result of the test
Acute toxicity test: owing to its mouse oral median lethal dose(LD 50) is not measured, so carry out the mensuration of mice oral 1 time maximum tolerated dose on the 1st.Oral 1 time the maximum tolerated dose on the 1st of mice is 50g/kg, none animal dead in the 7d, and the mice food ration is normal, weight increase, and glossy, submissive by hair, no loose stool and other exception table are existing.The mice maximum tolerated dose is equivalent to 139 times of clinical application amount (0.36g/kg).Illustrate YANG invigorating also five kinds of flaccidity in infant soup capsule be the bigger medicine of safety.
Subacute toxicity test: ordinary circumstance duration of test activities in rats, appetite, hair color and fecaluria no abnormality seen.Through variance analysis, the growth promoter of each medication treated animal and matched group be no significant difference (P＞0.05) relatively.Show that Yang recuperating decoction soft capsule has no adverse effects to the growth promoter of rat.Each organizes rat weightening finish situation (seeing Table 1).
The influence that table 1 Yang recuperating decoction soft capsule increases weight to rat (.X ± S)
| Group | Number of animals only | Dosage (mgkg-1) | Average starting weight (g only-1) | Average end heavy (g only-1) | Average weight gain (g only-1) |
| I II III IV | 15 15 15 15 | 0 5000 16667 50000 | 138.9±7.4 136.5±6.8 141.2±6.4 137.3±7.2 | 237.3±13.2 236.8±11.6 238.7±14.7 238.6±12.5 | 98.4±6.5 100.3±7.1 97.5±6.2 101.3±5.7 |
The influence of Yang recuperating decoction soft capsule and serum biochemistry index conventional to rat serum, the result sees Table 2 and table 3 respectively, and each is organized does not relatively have significant difference (P＞0.05) between rat serum routine and the serum biochemistry index.Show that Yang recuperating decoction soft capsule has no adverse effects to various blood cells, liver function and renal function.
Table 2 Yang recuperating decoction soft capsule is to the influence of rat serum conventional index (.X ± S)
| Group | Leukocyte count (109L-1) | RBC number (1012L-1) | Hemoglobin (gmL-1) | Platelet (109L-1) | Neutrophilic leukocyte % | Lymphocyte % |
| I II III IV | 9.13±2.51 8.94±3.12 9.37±2.79 9.16±3.78 | 7.98±0.84 8.12±0.76 7.69±0.72 8.76±0.67 | 137±11 132±9 129±13 140±14 | 219±37 215±41 228±32 207±24 | 23.5±3.7 24.6±3.1 25.6±3.2 24.1±2.9 | 74.2±6.9 73.6±5.3 73.3±6.3 74.4±6.4 |
Table 3 Yang recuperating decoction soft capsule is to the influence of rat blood serum biochemical indicator (.X ± S)
| Group | Alkali phosphatase (UL-1) | The millet straw transaminase/(UL-1) | Total protein (gL-1) | Albumin (gL-1) | Blood urea nitrogen (mnolL-1) | Creatinine (μ molL-1) |
| I II III IV | 118.7±31.4 121.3±27.2 119.5±33.6 120.4±34.8 | 178.3±23.2 169.4±31.5 176.5±25.8 180.3±19.7 | 74.6±4.9 75.9±3.7 74.1±5.2 78.7±4.8 | 37.7±1.8 38.1±2.1 37.9±1.7 39.6±2.3 | 6.72±0.14 7.04±0.16 6.78±0.21 6.92±0.17 | 64.3±3.3 67.8±2.5 66.2±4.1 63.8±2.7 |
Table 4 Yang recuperating decoction soft capsule is to the influence of Rats Organs and Tissues coefficient (X ± S)
| Group | The heart | Liver | Spleen | Lung | Kidney |
| I II III IV | 0.36±0.02 0.37±0.03 0.40±0.03 0.37±0.04 | 3.74±0.21 3.78±0.19 4.0±0.24 3.87±0.17 | 0.29±0.04 0.27±0.06 0.31±0.05 0.34±0.06 | 0.57±0.04 0.61±0.07 0.59±0.06 0.58±0.08 | 0.68±0.07 0.64±0.09 0.71±0.07 0.67±0.06 |
Yang recuperating decoction soft capsule the results are shown in Table 4 to the influence of Rats Organs and Tissues coefficient, and each organizes between the Rats Organs and Tissues coefficient comparing difference not significantly (P＞0.05).Show that Yang recuperating decoction soft capsule is to the harmless effect of the main parenchymatous organ of rat.
The maximum tolerated dose of Yang recuperating decoction soft capsule its mouse oral administration is 50g/kg.The detection explanation Yang recuperating decoction soft capsule of routine blood test has no adverse effects to various hemocytees and the bone marrow hematogenesis function of rat; Detection to serum neutral and alkali phosphatase, glutamic oxaloacetic transaminase, GOT, total protein, albumin and creatinine shows that Yang recuperating decoction soft capsule does not have influence to the liver function of rat; The serum urea nitrogen level is the important indicator of reflection renal function, and testing result shows that it changes in normal range, and the renal function no abnormality seen illustrates renal function is had no adverse effects.Organ coefficient is that reflection is tried to the sensitivity of some organ injury degree and effectively index of thing in the toxicology, and the result shows that Yang recuperating decoction soft capsule is to harmless effects of parenchymatous organ such as the heart, liver, spleen, lung and kidneys.Result of the test shows that Yang recuperating decoction soft capsule toxicity is lower, can guarantee that clinical safety uses.
4. the Yang recuperating decoction soft capsule of this Technology production is more evident in efficacy than other dosage form product of BUYANG HUANWU TANG of existing explained hereafter.Show through the animal pharmacology pharmacodynamics test: Yang recuperating decoction soft capsule can obviously alleviate the rat delayed ischemic neurological deficits, alleviates cerebral edema, reduces ischemia-reperfusion cerebral infarction scope and pathological lesion, and significantly better than every index of embolism extinguishing oral liquid.Show that Yang recuperating decoction soft capsule has protective effect to focal brain ischemia-reperfusion injury.Experimental result provides strong rationale for Yang recuperating decoction soft capsule is used for the treatment of cerebral infarction clinically.Experimentation is as follows:
A. animal pharmacology model preparation:
Animal feeding and room temperature are controlled at about 25 ℃, and fasting 12h before the art adopts improvement Langa legal system to make the MACO model, rat with 10% chloral hydrate (0.35ml/100g) intraperitoneal injection of anesthesia after, it is fixing to lie on the back, the skin of neck iodophor disinfection; Cervical region medisection, passivity is separated right carotid (CCA), external carotid artery (ECA), internal carotid artery (ICA), and separate wing hip tremulous pulse (PPA) downwards along ICA, ligation PPA, EC and CCA proximal part are equipped with line in distal end, the nearly crotch otch of CCA, insert the bolt line, the degree of depth 18.5 ± 0.5mm blocks middle cerebral artery to anterior cerebral artery; Tighten line fully then, stay 1cm fishing the end of a thread outward, skin suture.Lift institute's the end of a thread that stays when pouring into gently again and represent the setline head end to the CCA incision when resistance is arranged, promptly re-perfusion model forms.Sham operated rats bolt line insertion depth is in 15mm, and this degree of depth is not enough to block middle cerebral artery.Room temperature remains on 25-30 ℃ in the art, and anus temperature (37.5 soil 0.5) C is kept in the 100W incandescent lighting.
The sign of model success is: (1) receives flexing in the left fore when carrying tail; (2) homonymy Homer levies (promptly with surveying enophthalmos, palpebral fissure diminishes); Turn-take to the left when (3) creeping.Non-compliant animal is rejected.Ischemia 2h pours into 24h again.
B. test grouping and administration:
40 of Sprague-Dawley rats are divided into 5 groups at random, 8 every group:
Sham operated rats (sham group); Inserting the line bolt degree of depth is in the 15mm, and this degree of depth is not enough to block middle cerebral artery;
Ischemia filling group again (ischemia-reperfusion, IR group);
Embolism extinguishing oral liquid group (matched group): ischemia is irritated and is irritated stomach 10g.kg simultaneously
-1
Yang recuperating decoction soft capsule group (experimental group): ischemia is irritated and is irritated stomach 10g.kg simultaneously
-1
Positive controls: ischemia is irritated subcutaneous injection nimodipine 1mg.kg simultaneously again
-1
C. medication:
Yang recuperating decoction soft capsule group and embolism extinguishing oral liquid group adopt administration by gavage, successive administration 7d, and 30min implements cerebral ischemia re-pouring hands art after the last administration; Sham operated rats and ischemia filling group again are respectively with the normal saline 0.1ml.100g of equivalent
-1Irritate stomach; Nimodipine 1mg.kg
-130min subcutaneous injection before the art.
D compares the influence of pouring into the back delayed ischemic neurological deficits again
Ischemia filling group again delayed ischemic neurological deficits symptom is the most obvious when pouring into 30min again, pours into 3h again, and 24h recovers to some extent.Yang recuperating decoction soft capsule group, embolism extinguishing oral liquid group all can obviously alleviate pours into 30min again, the delayed ischemic neurological deficits symptom of 3h and 24h, but Yang recuperating decoction soft capsule group effect is more obvious, and both compare no significant difference with the nimodipine group.
Table 4, YANG invigorating also the five kinds of flaccidity in infant capsule to focal brain ischemia-reperfusion injury in rats 30min, 3h, the comparison of the influence of 24h delayed ischemic neurological deficits (x ± s, n=8)
| Group | Dosage | 30min | Scoring 3h | 24h |
| Ischemia filling group again matched group experimental group positive controls | - 10g·kg -1 10g·kg -1 10mg·g -1 | 4.3±0.5 3.1±0.3 2.4±0.6 2.7±0.4 | 3.6±0.6 2.9±0.20 2.3±0.3 2.6±0.1 | 2.8±0.30 2.4±0.20 2.1±0.40 2.3±0.30 |
E.BHD is to the influence of perfusion back brain water content again
The visible ischemia-reperfusion group cerebral tissue of naked eyes is pale, swelling is obvious, the cerebral hemisphere centre joint moves to strong lateral deviation, its brain water content is apparently higher than Sham-operated control group (P＜0.01), YANG invigorating also five kinds of flaccidity in infant Capsules group, embolism extinguishing oral liquid group all can suppress brain water content increase (P＜0.01, P＜0.05), compares no significant difference with the nimodipine group.(seeing Table 5)
F.BHD is to pouring into the influence of hindbrain infarction size again
With the ischemia-reperfusion group ratio, Yang recuperating decoction soft capsule group and nimodipine group all can make the rat cerebral infarction scope obviously dwindle (P＜0.01), and both compare no significant difference; Embolism extinguishing oral liquid group also can be dwindled cerebral infarction scope (P＜0.05), but effect not as YANG invigorating also the five kinds of flaccidity in infant capsule obviously (P＜0.05) (see Table 5,) table 5 YANG invigorating also the five kinds of flaccidity in infant capsule to the influence of focal brain ischemia-reperfusion injury in rats brain water content and infarction size relatively (x ± s, n=8)
| Group | Dosage | Infarction size (%) | Brain water content (%) |
| Sham operated rats ischemia filling group again matched group experimental group positive controls | - - 10g，kg -1 10g，kg -1 1mg·kg -1 | 77.79±0.33 83.39±0.33 80.06±0.22 78.06±0.42 78.59±0.26 | - 23.6±4.7 17.8±5.2 12.3±5.3 13.4±4.1 |
G. pathological change
Visible ischemia-reperfusion infarction side cerebral tissue shows as that a large amount of neuron peripheral clearances enlarge, cell is shrunk under the light microscopic, endochylema densely dyes, karyopyknosis or fragmentation, and matched group and experimental group infarction side cerebral tissue then obviously alleviate.Visible sham operated rats ultrastructure is normal under the Electronic Speculum; Ischemia filling group again glial cell body edema, the nuclear membrane boundary is unclear, became uneven, mitochondrial swelling, ridge is fuzzy, fracture, the chromatin limit is poly-in the nuclear, capillary endothelial cell form and cell membrane are irregular, indentation, junction opened, the obvious swelling of rough endoplasmic reticulum, ribosome takes off mistake, kytoplasm swelling, and concentration increases; Yang recuperating decoction soft capsule group cell boundary is clear, structural integrity, and the mitochondrion major part is intact, and ridge is prominent more complete, and rough endoplasmic reticulum is abundanter, and ribosome sees that the capillary endothelium structure is normal more, cell connects closely.The pathology improvement slightly is better than embolism extinguishing oral liquid group, but not remarkable.
5. the Technology Chinese medicinal soft capsule dosage form of producing, in extraction process, select former traditional water decocting process for use, reduced the spissated technical process of alcohol extraction of existing oral liquid, tablet, granule, reduced cost, only one of extraction process just reduces the cost nearly 10.
6. the soft capsule produced of this Technology is compared not only taking convenience, is easy to carry with the maximum embolism extinguishing oral liquid of present clinical employing, also reduced only one of oral liquid bottle of packing cost, and every day, dosage reduced nearly 0.3 yuan of direct cost.And improved exterior quality, and improved the quality of tcm product, have international standard.
The specific embodiment of the present invention:
Embodiment 1:
A kind of preparation method of Yang recuperating decoction soft capsule, it comprises: at first with Radix Astragali 120 grams, Radix Angelicae Sinensis 6 grams, Radix Paeoniae Rubra 4.5 grams, Pheretima 3 grams, Rhizoma Chuanxiong 3 grams, Semen Persicae 3 grams, Flos Carthami 3 grams, go mud to clean, put it in the multi-functional Chinese medicine extraction pot, decoct with water three times, 1 hour for the first time, be respectively for the second time, for the third time 1.5 hours; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; Filtrate is evaporated to relative density under 60 ℃ be 1.05, then its spray drying become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 30% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Make capsule-core concrete oil substrate liquid with the gelatin that adds brown pigment as the capsule material, under 70 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is made soft capsule; Drying, wash ball, drying makes soft capsule.
Embodiment 2:
The preparation method of embodiment 1 described Yang recuperating decoction soft capsule, it comprises: at first Radix Astragali 120 restrains, Radix Angelicae Sinensis 6 grams, Radix Paeoniae Rubra 4.5 grams, Pheretima 3 grams, Rhizoma Chuanxiong 3 grams, Semen Persicae 3 grams, Flos Carthami 3 grams go mud to clean, put it in the multi-functional Chinese medicine extraction pot, decoct with water three times, 2 hours for the first time, be respectively for the second time, for the third time 1 hour; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; Filtrate is evaporated to relative density under 80 ℃ be 1.10, then its spray drying become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 40% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Make capsule-core concrete oil substrate liquid with the gelatin that adds brown pigment as the capsule material, under 80 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is made soft capsule; Drying, wash ball, drying makes soft capsule.
Embodiment 3:
The preparation method of embodiment 1 or 2 Yang recuperating decoction soft capsules, it comprises: at first Radix Astragali 120 restrains, Radix Angelicae Sinensis 6 grams, Radix Paeoniae Rubra 4.5 grams, Pheretima 3 grams, Rhizoma Chuanxiong 3 grams, Semen Persicae 3 grams, Flos Carthami 3 grams, go mud to clean, put it in the multi-functional Chinese medicine extraction pot, decoct with water three times, 1.5 hours for the first time, be respectively for the second time, for the third time 1 hour; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; Filtrate is evaporated to relative density under 70 ℃ be 1.05, then its spray drying become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for 35% of oil matrix amount in the soft capsule, then mixture is carried out the homogenizing grinding with colloid mill; Make capsule-core concrete oil substrate liquid with the gelatin that adds brown pigment as the capsule material, under 75 ℃ of stirring conditions, capsule-core concrete oil substrate hydraulic pressure is made soft capsule; Drying, wash ball, drying makes soft capsule.
Claims (1)
1. the preparation method of a Yang recuperating decoction soft capsule, it comprises: at first by weight with 120 parts of Radix Astragali, and 6 parts of Radix Angelicae Sinensis, 4.5 parts of Radix Paeoniae Rubra, 3 parts of Pheretimas, 3 parts of Rhizoma Chuanxiongs, 3 parts in Semen Persicae, 3 parts of Chinese crude drugs of Flos Carthami, put into the Chinese medicine extraction jar, it is characterized in that: the Chinese medicine in the medicinal cupping in above-mentioned is decocted with water three times, 1-2 hour for the first time, be respectively for the second time, for the third time 1-1.5 hour; Collect volatile oil simultaneously, merge the water decoction extracting solution, centrifugal filtration; Filtrate is evaporated to relative density under 60-80 ℃ be 1.05-1.10, then its spray drying become dry extract and pulverizing, is fineness less than 120 orders; The volatile oil that extracts is dissolved in a certain amount of edible oil, the edible oil of dry extract with the volatile oil that is dissolved with extraction mixed, dry extract accounts for the 30-40% of oil matrix amount in the soft capsule, then mixture is carried out homogenizing with colloid mill and grinds; Make capsule-core concrete oil substrate liquid with the gelatin that adds brown pigment as the capsule material, under 70-80 ℃ of stirring condition, capsule-core concrete oil substrate hydraulic pressure is made soft capsule; Drying, wash ball, drying makes soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100100109A CN101062130B (en) | 2006-04-30 | 2006-04-30 | Yang recuperating decoction soft capsule preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100100109A CN101062130B (en) | 2006-04-30 | 2006-04-30 | Yang recuperating decoction soft capsule preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101062130A true CN101062130A (en) | 2007-10-31 |
| CN101062130B CN101062130B (en) | 2011-06-15 |
Family
ID=38963544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100100109A Expired - Fee Related CN101062130B (en) | 2006-04-30 | 2006-04-30 | Yang recuperating decoction soft capsule preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101062130B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658565A (en) * | 2009-08-10 | 2010-03-03 | 黄山 | Granules for benefiting qi and removing blood stasis |
| CN102274313A (en) * | 2011-08-10 | 2011-12-14 | 王济见 | Medicine for treating hemiplegia |
| CN102697904A (en) * | 2012-05-24 | 2012-10-03 | 上海交通大学医学院附属新华医院崇明分院 | Traditional Chinese medicine composition for treating acute cerebral infarction as well as preparation method and application of traditional Chinese medicine composition |
| CN102879516A (en) * | 2012-09-25 | 2013-01-16 | 南京中医药大学 | Method for identifying Buyang Huanwu soup and measuring content of Buyang Huanwu soup |
| CN116650567A (en) * | 2023-06-28 | 2023-08-29 | 湖南中医药大学 | Composition for improving vascular aging and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299670C (en) * | 2004-06-08 | 2007-02-14 | 江苏吴中中药研发有限公司 | Capsules for eliminating embolism and their preparation |
-
2006
- 2006-04-30 CN CN2006100100109A patent/CN101062130B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658565A (en) * | 2009-08-10 | 2010-03-03 | 黄山 | Granules for benefiting qi and removing blood stasis |
| CN102274313A (en) * | 2011-08-10 | 2011-12-14 | 王济见 | Medicine for treating hemiplegia |
| CN102697904A (en) * | 2012-05-24 | 2012-10-03 | 上海交通大学医学院附属新华医院崇明分院 | Traditional Chinese medicine composition for treating acute cerebral infarction as well as preparation method and application of traditional Chinese medicine composition |
| CN102879516A (en) * | 2012-09-25 | 2013-01-16 | 南京中医药大学 | Method for identifying Buyang Huanwu soup and measuring content of Buyang Huanwu soup |
| CN102879516B (en) * | 2012-09-25 | 2014-07-30 | 南京中医药大学 | Method for identifying Buyang Huanwu soup and measuring content of Buyang Huanwu soup |
| CN116650567A (en) * | 2023-06-28 | 2023-08-29 | 湖南中医药大学 | Composition for improving vascular aging and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101062130B (en) | 2011-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1723981A (en) | Novel use of extractive of Momordica grosvenori as adjuvant drug for preparing medicine | |
| CN101062130B (en) | Yang recuperating decoction soft capsule preparing method | |
| CN101327302B (en) | Chuan Xiong Tea soft capsule and method for preparing the same | |
| CN1058614C (en) | Galenic composition | |
| CN101085039B (en) | Composition for preventing and treating diabetes (hyperglycaemia) and its preparation method | |
| CN100528214C (en) | Capsule for treating epilepsia and its preparing method | |
| CN103933487A (en) | Compound traditional Chinese medicament for treating depression | |
| CN101953887B (en) | Medicinal composition for preventing and treating diabetic complications and preparation method thereof | |
| CN1927324A (en) | Preparation method of traditional medicine preparation for treating women's menoxenia | |
| CN100518781C (en) | Xiegan-anshen oral-preparation preparing method and preparation thereof | |
| CN100509009C (en) | A Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases and ischemic apoplexy, and its preparation method | |
| CN1067901C (en) | Drug for curing migraine and its preparing method | |
| CN102018852A (en) | Ginseng and coptis capsule for quenching thirsty and reducing blood sugar and preparation process | |
| CN1692938A (en) | Compound traditional Chinese medicine for improving eyesight and its prepn. method | |
| CN1839934A (en) | Chinese traditional medicine and its preparation method and use | |
| CN1272047C (en) | Medicine for invigorating liver and kidney to treat dryness of large intestine and constipation | |
| CN100486621C (en) | Chinese medicinal composition for treating hemilateral headache and its preparation method | |
| CN105664102A (en) | Traditional Chinese medicine composition for improving immunity | |
| CN1931286A (en) | Chinese medicine composition for treating lung cancer caused pain | |
| CN103989940A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN1245199C (en) | Oral medicinal composition for treating diabetes | |
| CN1695715A (en) | Medication for treating dementia in blood vessel type, and preparation method | |
| CN1216626C (en) | Shenhong capsule with actions of removing blood stasis and obstruction | |
| CN113521131B (en) | Traditional Chinese medicine composition for ischemic cardiomyopathy and application thereof | |
| CN108175818B (en) | Traditional Chinese medicine composition for treating glaucoma and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110615 Termination date: 20120430 |