CN103933487A - Compound traditional Chinese medicament for treating depression - Google Patents
Compound traditional Chinese medicament for treating depression Download PDFInfo
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- CN103933487A CN103933487A CN201410194263.0A CN201410194263A CN103933487A CN 103933487 A CN103933487 A CN 103933487A CN 201410194263 A CN201410194263 A CN 201410194263A CN 103933487 A CN103933487 A CN 103933487A
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Abstract
The invention provides a compound traditional Chinese medicament for treating depression, and relates to compound traditional Chinese medicaments. The compound traditional Chinese medicament is prepared from the following raw materials in parts by mass: 0.5-2 parts of radix bupleuri, 0.5-2 parts of radix curcumae, 0.5-2 parts of ginseng, 0.3-1 part of pinellia ternate, 1-3 parts of poria cocos, 0.5-1.5 parts of dried tangerine peel, 0.5-1 part of immature bitter orange, 0.3-1 part of bamboo shavings and 0-1 part of liquorice. The compound traditional Chinese medicament has the effects of resolving depression and eliminating phlegm, strengthening spleen and nourishing heart, and can be used for treating patients with mild or moderate depression with syndromes of qi depression and phlegm obstruction, and deficiency of heart and spleen. Pharmacodynamics study indicates that the medicinal composition can be used for remarkably antagonizing a rat with chronic unpredictable mild stress, increasing the crossing score and rearing score of a model rat and improving the behavioral state, wherein the action mechanism of the medicinal composition is closely related to improvement of the content of hypothalamus NE, DA and 5-HT, the concentrations of ACTH (adrenocorticotropic hormone) and COR (cortisol) of serum, the content of seahorse cAMP (cyclic adenosine monophosphate) and the contents of copper and zinc of serum.
Description
Technical field
The present invention relates to herbal mixture, especially relate to a kind of herbal mixture of Cure of depression.
Background technology
Depression is a kind of common mood disorders, can be caused by a variety of causes, and low as main clinical characteristics taking remarkable and lasting mental state, suicidal thought and behavior can appear in severe patient.According to World Health Organization's statistics, the sickness rate of global depression is 11%, and number of the infected reaches 1.2 hundred million, has become the large illness in the world the 4th, expects the year two thousand twenty, and depression may become the second largest disease that is only second to coronary heart disease.In recent years, because work rhythm quickening, life stress increase, various stressors increases, the sickness rate of China's depression constantly raises, and has reached 12.5%, and is the trend of becoming younger.But, because the cause and onset of disease mechanism of primary disease is intricate, illustrate not yet completely, Drug therapy or only for certain mechanism, its action spectrum is narrower, or need long-term taking, even there is the untoward reaction such as Liver and kidney toxicity, clinical practice is restricted.Therefore, strengthen the research for the treatment of depression scheme, control primary disease is had to great science and social meaning.
Though Chinese medicine is recorded without depression name of disease, according to its symptom, can be belonged to the categories such as the traditional Chinese medical science " melancholia ", " Bulbus Lilii syndrome ", " hysteria ".Because it is from the beginning of being main mainly with the domination of pathogen such as the stagnation of QI, stagnation of phlegm, sick wasting QI-blood for a long time, undermines heart spleen and forms the card of simulataneous insufficiency and excessive.Already confirmed, the depression comprehensive effect of Chinese medicine compound multipath, too many levels, is that the advantage of its Chinese medicine organic conception embodies, and has become a kind of Critical policies of depression study on prevention.Chinese patent CN102370727A discloses a kind of Chinese traditional compound medicine of Cure of depression, comprises the raw material of Chinese medicine of following weight proportioning: Radix Bupleuri 8～12, the Radix Paeoniae Alba 8～12, Poria 10～14, Radix Angelicae Sinensis 8～12, the Rhizoma Pinelliae 10～14, Cortex Magnoliae Officinalis 8～12, Rhizoma Acori Graminei 8～12, Radix Curcumae 8～12, Os Draconis 13～17, Concha Ostreae 13～17, Radix Glycyrrhizae 5～7; Its preparation method is that above-mentioned 11 taste medical materials are cleaned, be mixed in proportion, add the water of 6～8 times of medical material gross weight or ethanol that volume ratio is 70% and decoct 3 times, each 50 minutes, merge 3 times decoction liquor, filter, and concentrated, the fluid extract that while obtaining 60 DEG C, proportion is 1.17, adopts conventional preparation technology, can be made into said dosage form on any pharmaceutics, as tablet, capsule, granule, oral liquid, pill, syrup.
Summary of the invention
The object of this invention is to provide a kind of herbal mixture of Cure of depression.
The present invention's raw material in mass ratio consists of: Radix Bupleuri 0.5～2, Radix Curcumae 0.5～2, Radix Ginseng 0.5～2, the Rhizoma Pinelliae 0.3～1, Poria 1～3, Pericarpium Citri Reticulatae 0.5～1.5, Fructus Aurantii Immaturus 0.5～1, Caulis Bambusae In Taenia 0.3～1, Radix Glycyrrhizae 0～1.
The preparation method of the herbal mixture of Cure of depression of the present invention can adopt the conventional method of pharmaceutical field, uses conventional pharmaceutic adjuvant to carry out.For example adopt conventional method that extract is mixed with carrier or adjuvant conventional at least one pharmaceutics, then make various peroral dosage forms.Described carrier can be selected from least one in excipient, filler, diluent, lubricant, wetting agent, disintegrating agent, surfactant, antiseptic, sweeting agent, aromatic etc.Particularly, such as starch, dextrin, lactose, microcrystalline Cellulose, hydroxypropyl methylcellulose, Polyethylene Glycol, magnesium stearate, micropowder silica gel, glucose, mannitol, xylitol, glycine etc. of described carrier.
As required, the herbal mixture of Cure of depression of the present invention can be made into the preparation that is suitable for oral medication, and described preparation can be selected from the one in tablet, capsule, soft capsule, granule, drop pill, dispersible tablet, oral cavity disintegration tablet, pill, oral liquid etc.
The herbal mixture of Cure of depression of the present invention is taken after can decocting, also can water or ethanol extraction after take.
The using dosage of the herbal mixture of Cure of depression of the present invention, if taking granule dosage form as example, patient's dosage every day is 10g, can every bag when preparation with 5g dress, each serving with 1 bag, within 1 day, take 2 times, taking continuously 1 month was 1 course for the treatment of.
The present invention's flavour of a drug of writing out a prescription share, and have resolving depression and reduce phlegm, the function of invigorating spleen and nourishing heart.The pharmacological research of compositions that the party is extracted shows, said composition has the anti-inhibitory action of specificity to chronic mild Unpredictability stress depression disease rat model, significantly increases the horizontal score of rat model and marks with the vertical behavioristics that must grade.
The invention discloses a kind of herbal mixture that is used for the treatment of depression.It separates through 0～75% ethanol extraction taking Radix Bupleuri, Radix Curcumae, Radix Ginseng, the Rhizoma Pinelliae, Poria, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Caulis Bambusae In Taenia, Radix Glycyrrhizae as raw material, makes certain dosage form.Above-mentioned nine medicines share, and resolving depression reduces phlegm, and invigorating spleen and nourishing heart belongs to stagnation of QI stagnation of phlegm, deficiency of both the heart and spleen person for light, moderate depressive patients.Pharmacodynamic study shows: pharmaceutical composition is antagonism chronic mild Unpredictability stress depression disease rat significantly, increase the horizontal score of rat model and vertical score, improve behavioristics's state, its mechanism of action with improve hypothalamus NE, DA, 5-HT content, serum ACTH, COR concentration and Hippocampus cAMP content, serum copper, zinc content is closely related.Said composition can be made medically acceptable oral formulations, as dosage forms such as tablet, capsule (soft capsule or hard capsule), granules, prove that from pharmacodynamic study the present invention has resolving depression and reduces phlegm, the function of invigorating spleen and nourishing heart, is effective compound recipe of Cure of depression.
Detailed description of the invention
For the present invention is further described in detail, provide specific embodiment, but only as illustrating the present invention, instead of in order to limit the scope of the invention.
The granule dosage form of embodiment 1 pharmaceutical composition of the present invention
Adopt routine to prepare granule method, get 1 part of Radix Bupleuri (described part can calculate by 100g, below identical), 1 part of Radix Curcumae, 1 part of Radix Ginseng, 1 part of the Rhizoma Pinelliae, 3 parts, Poria, 1 part of Pericarpium Citri Reticulatae, 0.5 part of Fructus Aurantii Immaturus, 1 part of Caulis Bambusae In Taenia, 0.5 part, Radix Glycyrrhizae, amount of water is respectively 10 times, 8 times, extracts for the first time 2h, extracts for the second time 1.5h, filter, merging filtrate, adds right amount of auxiliary materials after concentrating, be dried, pulverize, and mixes, granulate, sieve, be dried, make the drug combination preparation of granule dosage form.
The test of pesticide effectiveness of embodiment 2 present compositions and mechanism research
The object of this test is to observe the therapeutical effect of the present composition to rat depression model.Specific as follows:
1 material
1.1 laboratory animal SD male rats, 40, clean level, 180g left and right, is provided credit number SCXK (Soviet Union) 2002-0031 by Nanjing Medical University's Experimental Animal Center.
The 1.2 medicine present compositions adopt granule, and the used time is prepared desired concn with pure water.Other reagent chemicalses have maprotiline, are purchased from Novartis Pharma AG and produce, with being mixed with 1mg/ml suspension with distilled water before.
1.3 models preparations adopt chronic mild Unpredictabilities stress rat depression model.The every cage of Normal group is raised 6, normally takes the photograph diseases caused by retention of fluid food, does not give any stimulation.All the other rats except Normal group, every all single cage raising, and accept 21 days various stress stimulations, stimulating method, according to Katz method improvement, comprise: 2 48h fasting, 2 times 24h prohibits water, 2 illuminations (12h) all night, 24 DEG C of frozen water swimming 5min, 2 45 DEG C of baking oven baking the affected part after applying some drugs 5min, No. 2 folder tail 1min, 2 high level vibration (160Hz) 10min, put upside down round the clock for 2 times, 2 24h are moist raises (at the bottom of 200ml water being added to the cage that is covered with one deck wood sawdust, wood sawdust all being soaked) and 1 flash stimulation (120 times/s) 15min.Give at random a kind of stimulation every day, make the generation of the unpredictable stimulation of rat, adapt to avoid producing.
2 methods
2.1 modelings by SD male rat, are divided into normal group, model group, herbal mixture group, maprotiline group, 10 of every group of rats with grouping medication at random.Model group, herbal mixture group, maprotiline group are prepared scheme according to above-mentioned model and are given at random stress stimulation 21 days.Medicine group gavages heavily respectively corresponding medicine by 1ml/100g Mus, and every day 1 time, normal group, model group give the drinking water gavage of respective amount.
2.2 observation index
● Open-Field behavior scoring: in the 1st day, the scoring of the 22nd Tian Hang Open-Field behavioristics of experiment.
● hypothalamus NE, DA, 5-HT content detection.
● serum ACTH, COR concentration and Hippocampus cAMP content detection.
● serum copper, zinc content detection.
3 results
The impact that 3.1 herbal mixtures are learned rat behavior.
Depression model rat growth of weight is slow, and horizontal and vertical activity and sucrose solution consumption all obviously reduce (P < 0.05, P < 0.01).And herbal mixture can significantly improve rat behavior and learns index, there is remarkable antidepressant effect, for the follow-up correlational study that carries out Chinese medicine compound depression provides the pharmacodynamics foundation of science.
The impact of 3.2 herbal mixtures on rat blood serum ACTH, COR and Hippocampus cAMP content
Herbal mixture significantly reduces serum ACTH, COR concentration, promotes Hippocampus cAMP content, participates in regulating hpa axis function (table 1).
The each group of table 1 rat blood serum ACTH, COR and Hippocampus cAMP changes of contents
Note:
Δp<0.05,
Δ Δp<0.01vs normal group;
▲p<0.05,
▲ ▲p<0.01vs model group.
The impact of 3.3 herbal mixtures on amygdala in rats NE, 5-HT, DA content
Herbal mixture significantly raise corpus amygdaloideum NE, 5-HIAA, 5-HT, HVA, DA content, participate in the adjusting (table 2) to monoamine neurotransmitters.
The each group of table 2 amygdala in rats NE, 5-HT, DA changes of contents
Note:
Δp<0.05,
Δ Δp<0.01vs normal group;
▲p<0.05,
▲ ▲p<0.01vs model group.
The impact of 3.4 herbal mixtures on rat blood serum copper, zinc content
Herbal mixture significantly improves serum zinc content, reduces serum copper content, participates in regulating microelement (table 3).
The each group of table 3 rat blood serum copper, zinc changes of contents
Note:
Δp<0.05vs normal group;
▲p<0.05,
▲ ▲p<0.01vs model group
Pharmacodynamic study result shows, pharmaceutical composition of the present invention is the active drug of Cure of depression.
Claims (1)
1. a herbal mixture for Cure of depression, is characterized in that raw material in mass ratio consists of: Radix Bupleuri 0.5～2, Radix Curcumae 0.5～2, Radix Ginseng 0.5～2, the Rhizoma Pinelliae 0.3～1, Poria 1～3, Pericarpium Citri Reticulatae 0.5～1.5, Fructus Aurantii Immaturus 0.5～1, Caulis Bambusae In Taenia 0.3～1, Radix Glycyrrhizae 0～1.
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| CN201410194263.0A CN103933487A (en) | 2014-05-09 | 2014-05-09 | Compound traditional Chinese medicament for treating depression |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173800A (en) * | 2014-08-19 | 2014-12-03 | 冯小明 | Traditional Chinese medicine preparation for treating depression and preparation method thereof |
| CN104189867A (en) * | 2014-09-26 | 2014-12-10 | 田胜硕 | Traditional Chinese medicine composition for treating post-schizophrenic depression |
| CN104288677A (en) * | 2014-09-26 | 2015-01-21 | 广西中医药大学 | Yao medicine composition for treating depression and preparation method thereof |
| CN112043807A (en) * | 2020-09-03 | 2020-12-08 | 中国人民解放军63919部队 | Anti-depression traditional Chinese medicine compound |
| CN115501305A (en) * | 2022-10-25 | 2022-12-23 | 许二平 | Traditional Chinese medicine composition for treating liver depression and spleen deficiency damp excess type depression and application thereof |
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| CN1308959A (en) * | 2001-01-12 | 2001-08-22 | 王东桥 | Medicine 'Yishenjieyu' for treating mental diseases (psychosis) |
| CN101011561A (en) * | 2006-11-01 | 2007-08-08 | 黄达驹 | Modern traditional Chinese medicine oral preparation huanglianwendan decoction and production method thereof |
| CN101530599A (en) * | 2009-04-20 | 2009-09-16 | 高新华 | A pharmaceutical composition for treating mental depression |
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2014
- 2014-05-09 CN CN201410194263.0A patent/CN103933487A/en active Pending
Patent Citations (3)
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|---|---|---|---|---|
| CN1308959A (en) * | 2001-01-12 | 2001-08-22 | 王东桥 | Medicine 'Yishenjieyu' for treating mental diseases (psychosis) |
| CN101011561A (en) * | 2006-11-01 | 2007-08-08 | 黄达驹 | Modern traditional Chinese medicine oral preparation huanglianwendan decoction and production method thereof |
| CN101530599A (en) * | 2009-04-20 | 2009-09-16 | 高新华 | A pharmaceutical composition for treating mental depression |
Non-Patent Citations (1)
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| 陈艳玲等: "柴郁温胆汤及其拆方对慢性应激抑郁大鼠的作用", 《安徽中医学院学报》, vol. 32, no. 2, 30 April 2013 (2013-04-30), pages 64 - 68 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173800A (en) * | 2014-08-19 | 2014-12-03 | 冯小明 | Traditional Chinese medicine preparation for treating depression and preparation method thereof |
| CN104173800B (en) * | 2014-08-19 | 2017-09-08 | 冯小明 | It is a kind of to treat Chinese medicine preparation of depression and preparation method thereof |
| CN104189867A (en) * | 2014-09-26 | 2014-12-10 | 田胜硕 | Traditional Chinese medicine composition for treating post-schizophrenic depression |
| CN104288677A (en) * | 2014-09-26 | 2015-01-21 | 广西中医药大学 | Yao medicine composition for treating depression and preparation method thereof |
| CN104288677B (en) * | 2014-09-26 | 2017-11-03 | 广西中医药大学 | It is a kind of to treat precious jade medicine compound of depression and preparation method thereof |
| CN112043807A (en) * | 2020-09-03 | 2020-12-08 | 中国人民解放军63919部队 | Anti-depression traditional Chinese medicine compound |
| CN115501305A (en) * | 2022-10-25 | 2022-12-23 | 许二平 | Traditional Chinese medicine composition for treating liver depression and spleen deficiency damp excess type depression and application thereof |
| CN115501305B (en) * | 2022-10-25 | 2023-11-21 | 许二平 | Traditional Chinese medicine composition for treating depression caused by liver depression and spleen deficiency and excessive dampness and application thereof |
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Application publication date: 20140723 |