CN113425769A - Traditional Chinese medicine composition for treating arthralgia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating arthralgia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating arthralgia and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw material components: 1-6 parts of kusnezoff monkshood root, 2-6 parts of ground beetle, 1-2 parts of scorpion, 1-2 parts of centipede, 2-6 parts of szechuan lovage rhizome, 2-8 parts of kadsura pepper stem, 5-10 parts of rose mallow and 2-6 parts of garden balsam stem, and the medicine can treat diseases such as arthralgia and has a good treatment effect; the preparation method comprises the following steps: the preparation method comprises the steps of crushing, grinding and sieving kusnezoff monkshood root, eupolyphaga, scorpion, centipede, ligusticum wallichii, kadsura pepper stem, radix cynanchi bungei and garden balsam stem, adding ethanol, refluxing and extracting, and concentrating to obtain an extract.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating arthralgia and a preparation method thereof.
Background
The connection between bones is called bone connection. The bone connection is divided into direct connection and indirect connection, and the joint is a form of indirect connection and generally consists of three parts, namely a joint surface, a joint capsule and a joint cavity. Joints are also the structures necessary for differential growth, transmission of extension, shear, compression, torsion, and a wide variety of movements.
With the increase of age, the flexibility and the toughness of the joint are reduced to a certain degree, so that the joint is easy to be damaged by loss and can be induced to produce various joint diseases, the most intuitive symptom is joint pain, the daily life of people can be affected very adversely, and meanwhile, the pain can be brought. Therefore, the development of a medicament capable of treating diseases such as arthralgia and the like is very important.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating arthralgia, which can treat diseases such as arthralgia and has a good treatment effect.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating arthralgia, which has simple process, and the prepared medicine has good treatment effect and convenient use.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the invention provides a traditional Chinese medicine composition for treating arthralgia, which comprises the following raw material components: 1-6 parts of kusnezoff monkshood root, 2-6 parts of ground beetle, 1-2 parts of scorpion, 1-2 parts of centipede, 2-6 parts of szechuan lovage rhizome, 2-8 parts of kadsura pepper stem, 5-10 parts of rose mallow flower and 2-6 parts of garden balsam stem.
In another aspect, the embodiment of the present invention provides a preparation method of a traditional Chinese medicine composition for treating arthralgia, which includes the following steps: pulverizing radix Aconiti Kusnezoffii, Eupolyphaga Seu Steleophaga, Scorpio, Scolopendra, rhizoma Ligustici Chuanxiong, caulis Piperis Futokadsurae, flos Urenae Lobatae and caulis et folium Gaultheriae Yunnanensis, sieving, adding ethanol, reflux extracting, concentrating to obtain extract, and making into final product.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
aiming at the first aspect, the embodiment of the invention provides a traditional Chinese medicine composition for treating arthralgia, which comprises the following raw material components: 1-6 parts of kusnezoff monkshood root, 2-6 parts of ground beetle, 1-2 parts of scorpion, 1-2 parts of centipede, 2-6 parts of szechuan lovage rhizome, 2-8 parts of kadsura pepper stem, 5-10 parts of rose mallow flower and 2-6 parts of garden balsam stem.
In the above examples, the effects of the raw materials are as follows:
kusnezoff monkshood root: expelling wind and removing dampness, warming channel and expelling cold, and relieving swelling and pain; mainly wind-cold-damp arthralgia, headache, stroke, cold pain in the heart and abdomen, cold hernia pain, traumatic injury, swelling and pain due to blood stasis, yin gangrene and pyogenic infections, anesthesia and pain relief;
b, ground beetle: promoting blood circulation, removing blood stasis, dredging channels, and relieving pain; traumatic injury, blood stasis and swelling pain, broken bones and muscles, amenorrhea, postpartum abdominal pain due to blood stasis;
scorpion: calming endogenous wind, relieving spasm, counteracting toxic pathogen, resolving hard mass, dredging collaterals, and relieving pain; can be used for treating infantile convulsion, spasm, facial distortion due to apoplexy, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, and lymphoid tuberculosis;
centipede: wind-extinguishing, spasm-relieving, toxin-expelling, nodulation-dissipating, collateral-dredging and pain-relieving; can be used for treating infantile convulsion, spasm, facial distortion due to apoplexy, hemiplegia, tetanus, rheumatism, suppurative sore, lymphoid tuberculosis, and venomous snake bite;
ligusticum wallichii: promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia;
caulis piperis futokadsurae: dispelling wind-damp, dredging channels and collaterals, and relieving arthralgia; can be used for treating arthralgia due to wind-cold-dampness, pain of limbs and joints, spasm of tendons and vessels, and difficulty in flexion and extension.
And (3) peach blossom: dispelling pathogenic wind, promoting diuresis, promoting blood circulation, eliminating seed, and clearing away heat and toxic materials; cold, rheumatalgia, dysentery, diarrhea, stranguria syndrome, leukorrhagia, menoxenia, traumatic injury and swelling and pain, pharyngitis, acute mastitis, sore and furuncle, and venomous snake bite;
garden balsam stem: dispelling pathogenic wind and removing dampness, relieving rigidity of muscles and promoting blood circulation, removing blood stasis and detumescence, removing toxic substance and relieving eye pain; mainly wind-damp arthralgia, contracture of muscles and bones, cold-damp beriberi, waist sprain, paralysis, amenorrhea, eczema of scrotum, sore and furuncle pyogenic infections.
In the raw material medicinal materials of the traditional Chinese medicine composition for treating arthralgia, the kusnezoff monkshood root contains various alkaloids such as aconitine, hypaconitine, and glauconine, and the ethanol infusion has obvious analgesic effect, can treat joint diseases such as rheumatic arthritis, relieve the symptoms of arthralgia, and has certain effect of reducing fever; the eupolyphaga contains various volatile oils, amino acids, steroids, phenols, organic acids, alkaloids and various trace elements necessary for human bodies, has the anticoagulation effect, can play a role in promoting blood circulation and relieving pain, is beneficial to relieving symptoms such as arthralgia caused by joint diseases and the like, and also has the effects of regulating blood fat and resisting tumors; the scorpion contains polypeptide with antiepileptic activity and analgesic activity, trimethylamine, betaine, taurine and various amino acids, has the function of resisting convulsion, is beneficial to treating rheumatism and various joint symptoms caused by rheumatism, and also has the function of resisting tumors; centipede fatty oil, cholesterol, formic acid, amino acid and other substances, similar to scorpion, have the efficacies of resisting convulsion and tumor, and simultaneously have the antifungal effect, and can also treat rheumatic diseases; the ligusticum wallichii contains various substances such as tetramethylpyrazine and loline, also contains various volatile oils, has obvious sedation, can dilate blood vessels, has the effect of activating blood, can influence cell metabolism, enhances physiological functions, also has obvious effects of easing pain and inhibiting bacteria, and can effectively relieve symptoms such as arthralgia; the kadsura pepper stem contains various components such as the piperine, the piperitone stigmasterol and the volatile oil, has better curative effect on coronary heart disease and cerebral thrombosis, also has the effects of expelling wind-damp and relieving pain, and can treat rheumatic diseases and symptoms such as arthralgia caused by the rheumatic diseases; the rose mallow contains various substances such as phenolic components, amino acids, sterol and the like, and can treat diseases such as rheumatoid arthritis, rheumatic arthralgia and the like; the herba speranskiae tuberculatae contains various components such as indazole-3-acetonitrile, kaempferol-3-glucoside, quercetin-3-glucoside, etc., has the effects of dispelling pathogenic wind, removing dampness, promoting blood circulation, and relieving pain, and can be used for treating various rheumatic diseases and arthralgia. The raw material medicines are matched with each other, and the synergistic effect is realized, so that the medicinal materials can fully exert respective beneficial effects, and the treatment effect of the product medicine on symptoms such as arthralgia and the like caused by various joint diseases is enhanced.
In a second aspect, the embodiment of the present invention provides a preparation method of a traditional Chinese medicine composition for treating arthralgia, which includes the following steps: pulverizing radix Aconiti Kusnezoffii, Eupolyphaga Seu Steleophaga, Scorpio, Scolopendra, rhizoma Ligustici Chuanxiong, caulis Piperis Futokadsurae, flos Urenae Lobatae and caulis et folium Gaultheriae Yunnanensis, sieving, adding ethanol, reflux extracting, concentrating to obtain extract, and making into final product.
In the embodiment, firstly, the wu, the eupolyphaga, the scorpio, the centipede, the ligusticum wallichii, the kadsura pepper stem, the radix hyperici japonici and the garden balsam stem are crushed, ground and sieved, and the beneficial components in the medicinal materials can be better extracted in the subsequent steps by grinding the medicinal materials into powder, so that the treatment effect of the product medicament is enhanced, and the medicinal materials can fully exert respective beneficial effects; then adding ethanol for reflux extraction, and taking the ethanol as a solvent to extract beneficial components in the medicinal materials in a reflux extraction manner without damaging the beneficial components; then concentrating into extract, and further preparing into ointment and other finished medicines in different states, which is convenient and quick to use and is more beneficial to treatment. The whole preparation method is simple in flow, the prepared medicine can effectively relieve and treat various joint diseases, joint pain and other symptoms, the treatment effect is good, and the use is convenient and quick.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The invention provides a traditional Chinese medicine composition for treating arthralgia, which comprises the following raw material components: 1-6 parts of kusnezoff monkshood root, 2-6 parts of ground beetle, 1-2 parts of scorpion, 1-2 parts of centipede, 2-6 parts of szechuan lovage rhizome, 2-8 parts of kadsura pepper stem, 5-10 parts of rose mallow flower and 2-6 parts of garden balsam stem.
In the above examples, the effects of the raw materials are as follows:
kusnezoff monkshood root: expelling wind and removing dampness, warming channel and expelling cold, and relieving swelling and pain; mainly wind-cold-damp arthralgia, headache, stroke, cold pain in the heart and abdomen, cold hernia pain, traumatic injury, swelling and pain due to blood stasis, yin gangrene and pyogenic infections, anesthesia and pain relief;
b, ground beetle: promoting blood circulation, removing blood stasis, dredging channels, and relieving pain; traumatic injury, blood stasis and swelling pain, broken bones and muscles, amenorrhea, postpartum abdominal pain due to blood stasis;
scorpion: calming endogenous wind, relieving spasm, counteracting toxic pathogen, resolving hard mass, dredging collaterals, and relieving pain; can be used for treating infantile convulsion, spasm, facial distortion due to apoplexy, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, and lymphoid tuberculosis;
centipede: wind-extinguishing, spasm-relieving, toxin-expelling, nodulation-dissipating, collateral-dredging and pain-relieving; can be used for treating infantile convulsion, spasm, facial distortion due to apoplexy, hemiplegia, tetanus, rheumatism, suppurative sore, lymphoid tuberculosis, and venomous snake bite;
ligusticum wallichii: promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia;
caulis piperis futokadsurae: dispelling wind-damp, dredging channels and collaterals, and relieving arthralgia; can be used for treating arthralgia due to wind-cold-dampness, pain of limbs and joints, spasm of tendons and vessels, and difficulty in flexion and extension;
and (3) peach blossom: dispelling pathogenic wind, promoting diuresis, promoting blood circulation, eliminating seed, and clearing away heat and toxic materials; cold, rheumatalgia, dysentery, diarrhea, stranguria syndrome, leukorrhagia, menoxenia, traumatic injury and swelling and pain, pharyngitis, acute mastitis, sore and furuncle, and venomous snake bite;
garden balsam stem: dispelling pathogenic wind and removing dampness, relieving rigidity of muscles and promoting blood circulation, removing blood stasis and detumescence, removing toxic substance and relieving eye pain; mainly wind-damp arthralgia, contracture of muscles and bones, cold-damp beriberi, waist sprain, paralysis, amenorrhea, eczema of scrotum, sore and furuncle pyogenic infections.
In the raw material medicinal materials of the traditional Chinese medicine composition for treating arthralgia, the kusnezoff monkshood root contains various alkaloids such as aconitine, hypaconitine, and glauconine, and the ethanol infusion has obvious analgesic effect, can treat joint diseases such as rheumatic arthritis, relieve the symptoms of arthralgia, and has certain effect of reducing fever; the eupolyphaga contains various volatile oils, amino acids, steroids, phenols, organic acids, alkaloids and various trace elements necessary for human bodies, has the anticoagulation effect, can play a role in promoting blood circulation and relieving pain, is beneficial to relieving symptoms such as arthralgia caused by joint diseases and the like, and also has the effects of regulating blood fat and resisting tumors; the scorpion contains polypeptide with antiepileptic activity and analgesic activity, trimethylamine, betaine, taurine and various amino acids, has the function of resisting convulsion, is beneficial to treating rheumatism and various joint symptoms caused by rheumatism, and also has the function of resisting tumors; centipede fatty oil, cholesterol, formic acid, amino acid and other substances, similar to scorpion, have the efficacies of resisting convulsion and tumor, and simultaneously have the antifungal effect, and can also treat rheumatic diseases; the ligusticum wallichii contains various substances such as tetramethylpyrazine and loline, also contains various volatile oils, has obvious sedation, can dilate blood vessels, has the effect of activating blood, can influence cell metabolism, enhances physiological functions, also has obvious effects of easing pain and inhibiting bacteria, and can effectively relieve symptoms such as arthralgia; the kadsura pepper stem contains various components such as the piperine, the piperitone stigmasterol and the volatile oil, has better curative effect on coronary heart disease and cerebral thrombosis, also has the effects of expelling wind-damp and relieving pain, and can treat rheumatic diseases and symptoms such as arthralgia caused by the rheumatic diseases; the rose mallow contains various substances such as phenolic components, amino acids, sterol and the like, and can treat diseases such as rheumatoid arthritis, rheumatic arthralgia and the like; the herba speranskiae tuberculatae contains various components such as indazole-3-acetonitrile, kaempferol-3-glucoside, quercetin-3-glucoside, etc., has the effects of dispelling pathogenic wind, removing dampness, promoting blood circulation, and relieving pain, and can be used for treating various rheumatic diseases and arthralgia. The raw material medicines are matched with each other, and the synergistic effect is realized, so that the medicinal materials can fully exert respective beneficial effects, and the treatment effect of the product medicine on symptoms such as arthralgia and the like caused by various joint diseases is enhanced.
Further, in some embodiments of the present invention, the amounts of the raw materials are: 3 parts of kusnezoff monkshood root, 3 parts of ground beetle, 1.6 parts of scorpion, 1.2 parts of centipede, 5 parts of szechuan lovage rhizome, 7 parts of kadsura pepper stem, 8 parts of rose mallow and 5 parts of garden balsam stem.
In the above embodiment, the dosage ratio of each raw material is further limited, so that each raw material can be better matched with each other, a synergistic effect is achieved, each raw material can fully exert respective beneficial effects, adverse effects on the drug effect of the product due to improper dosage ratio of the raw materials can be avoided, the treatment effects of the product on symptoms such as arthralgia caused by various joint diseases are further enhanced, and the treatment effect is better.
Further, in some embodiments of the present invention, the raw material further comprises an osmotic agent in an amount of 1-2% by mass based on the total mass of the drug.
In the embodiment, the penetrant is added, so that the beneficial components in the medicine can be promoted to permeate into the skin to enter the body, the absorption of the human body to the medicine is promoted, the medicine effect is further promoted, the medicine dosage can be reduced on the premise of ensuring the sufficient treatment effect, the treatment of the product medicine can be further promoted, and the treatment effect of the product medicine on symptoms such as arthralgia is enhanced. In addition, the dosage of the penetrant is limited, so that the beneficial effects of the penetrant can be better exerted, and the adverse effects caused by improper dosage can be avoided.
Further, in some embodiments of the present invention, the osmotic agent is laurocapram.
In the above embodiment, through using laurocapram as the penetrant, the promotion medicine that can be better permeates, promotes the human absorption to beneficial component in the medicine to further promote the drug effect, strengthen the treatment of product medicine, laurocapram also has certain antibacterial effect simultaneously, helps further promoting the quality of product medicine, more is favorable to using.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating arthralgia, which comprises the following steps: pulverizing radix Aconiti Kusnezoffii, Eupolyphaga Seu Steleophaga, Scorpio, Scolopendra, rhizoma Ligustici Chuanxiong, caulis Piperis Futokadsurae, flos Urenae Lobatae and caulis et folium Gaultheriae Yunnanensis, sieving, adding ethanol, reflux extracting, concentrating to obtain extract, and making into final product.
In the embodiment, firstly, the wu, the eupolyphaga, the scorpio, the centipede, the ligusticum wallichii, the kadsura pepper stem, the radix hyperici japonici and the garden balsam stem are crushed, ground and sieved, and the beneficial components in the medicinal materials can be better extracted in the subsequent steps by grinding the medicinal materials into powder, so that the treatment effect of the product medicament is enhanced, and the medicinal materials can fully exert respective beneficial effects; then adding ethanol for reflux extraction, and taking the ethanol as a solvent to extract beneficial components in the medicinal materials in a reflux extraction manner without damaging the beneficial components; then concentrating into extract, and further preparing into ointment and other finished medicines in different states, which is convenient and quick to use and is more beneficial to treatment. The whole preparation method is simple in flow, the prepared medicine can effectively relieve and treat various joint diseases, joint pain and other symptoms, the treatment effect is good, and the use is convenient and quick.
Further, in some embodiments of the present invention, the mesh number of the screen is 120 mesh.
In the above embodiment, through the mesh number to the sieve restriction, can be better carry out further screening control to the particle size of the medicinal material granule after smashing through sieving, be favorable to like this fully extracting the beneficial component in each raw material medicinal material in follow-up step, make each medicinal material can be better combine together, mutually support, play synergistic effect, help further strengthen the therapeutic effect of product medicine to all kinds of symptoms such as arthralgia, can further promote the product quality.
Further, in some embodiments of the invention, 70% ethanol, 6 times the weight of the drug material, is added for reflux extraction.
In the above embodiment, through carrying out further control to the quantity and the concentration of ethanol, can be more abundant extract the useful component in each medicinal material through the mode of backward flow leaching, can avoid the useful component in the medicinal material to receive destruction or loss at the in-process of extracting, help further promoting the quality of product medicine, strengthen its therapeutic effect to all kinds of joint diseases.
Further, in some embodiments of the invention, the reflux extraction is repeated twice, each time adding 70% ethanol 6 times the weight of the raw drug, each time for 2 h.
In the above embodiment, by repeating the reflux extraction twice, and further limiting the ethanol dosage and concentration of the reflux extraction at each time and the extraction time, various beneficial components contained in the medicinal material can be more fully extracted, the loss and waste of the beneficial components of the medicinal material are reduced, the curative effect of the product medicament is further promoted, and the quality of the product medicament is further improved.
Further, in some embodiments of the invention, the extract is concentrated to a relative density of 1.3 after reflux extraction.
In the above embodiment, the ethanol solution after the reflux extraction is concentrated to the relative density of 1.3, so that the ethanol solution becomes an extract, which is helpful for further improving the drug effect, and meanwhile, the extract can be further prepared into other types of medicaments such as ointment, and the like, and can be used in cooperation with different use scenes, so that the use is more convenient, and the treatment is more facilitated.
Further, in some embodiments of the present invention, the composition is concentrated to an extract, and then an osmotic agent is added to prepare a plaster.
In the embodiment, the concentrated extract is added with the penetrating agent to prepare the plaster, and the plaster is smeared on the joint part of the focus when in actual use, so that the penetrating power of the plaster is enhanced by the penetrating agent, and the medicine can be fully absorbed by a human body, thereby further enhancing the treatment effect, being more convenient to use and being more beneficial to treatment.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating arthralgia, which is prepared by the following method:
taking 6g of kusnezoff monkshood root, 6g of eupolyphaga, 2g of scorpion, 2g of centipede, 6g of szechuan lovage rhizome, 8g of kadsura pepper stem, 10g of rose mallow and 6g of garden balsam stem, crushing, grinding, sieving by a 120-mesh sieve, carrying out reflux extraction twice, adding 276g of 70% ethanol for each time, extracting for 2 hours for each time, concentrating to obtain an extract with the relative density of 1.3, adding 0.92g of laurocapram, and preparing into the plaster.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating arthralgia, which is prepared by the following method:
taking 1g of radix aconiti agrestis, 2g of eupolyphaga, 1g of scorpion, 1g of centipede, 2g of ligusticum wallichii, 2g of kadsura pepper stem, 5g of prunus persica flower and 2g of garden balsam stem, crushing, grinding, sieving by a 120-mesh sieve, carrying out reflux extraction twice, adding 96g of 70% ethanol for each time, extracting for 2 hours for each time, concentrating to obtain an extract with the relative density of 1.3, adding 0.16g of laurocapram, and preparing into the plaster.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating arthralgia, which is prepared by the following method:
taking 3g of kusnezoff monkshood root, 4g of eupolyphaga, 1.5g of scorpion, 1.5g of centipede, 4g of szechuan lovage rhizome, 5g of kadsura pepper stem, 7g of rose mallow and 4g of garden balsam stem, crushing, grinding, sieving by a 120-mesh sieve, extracting twice under reflux, adding 180g of 70% ethanol each time, extracting for 2 hours each time, concentrating to obtain an extract with the relative density of 1.3, adding 0.45g of laurocapram, and preparing into the plaster.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating arthralgia, which is prepared by the following method:
taking 5g of kusnezoff monkshood root, 5g of eupolyphaga, 2g of scorpion, 1g of centipede, 4g of szechuan lovage rhizome, 3g of kadsura pepper stem, 7g of rose mallow and 4g of garden balsam stem, crushing, grinding, sieving by a 120-mesh sieve, extracting under reflux twice, adding 186g of 70% ethanol each time, extracting for 2 hours each time, concentrating to obtain an extract with the relative density of 1.3, adding 0.62g of laurocapram, and preparing into the plaster.
Example 5
The embodiment provides a traditional Chinese medicine composition for treating arthralgia, which is prepared by the following method:
taking 3g of kusnezoff monkshood root, 3g of eupolyphaga, 1.6g of scorpion, 1.2g of centipede, 5g of szechuan lovage rhizome, 7g of kadsura pepper stem, 8g of rose mallow and 5g of garden balsam stem, crushing, grinding, sieving by a 120-mesh sieve, extracting twice under reflux, adding 203g of 70% ethanol each time, extracting for 2 hours each time, concentrating to obtain an extract with the relative density of 1.3, adding 0.68g of laurocapram, and preparing into the plaster.
Test examples
The traditional Chinese medicine composition for treating arthralgia provided by the embodiment 5 of the invention is used for 36 patients suffering from rheumatic diseases and accompanied with arthralgia, wherein 12 men and 24 women wipe twice a day, the disease condition is continuously observed for 60 days, and the treatment effect is judged according to the following judgment criteria:
and (3) curing: the arthralgia completely disappears, and no relapse occurs;
the method has the following advantages: the symptoms of arthralgia are significantly relieved, but not completely eliminated;
and (4) invalidation: the symptoms before and after treatment are unchanged.
The observation results are shown in table 1:
TABLE 1
| Sex | Number of people/person | Cure/human | Effective/human | Invalid/human |
| For male | 12 | 10 | 2 | 0 |
| Woman | 24 | 21 | 2 | 1 |
According to the results, the traditional Chinese medicine composition for treating arthralgia provided by the invention can effectively treat symptoms such as arthralgia and has a good treatment effect.
The following are some typical cases:
the patient 1, female, is 39 years old, suffers from rheumatic arthritis, and has symptoms of pain in knee joints, muscular pain, hypodynamia and the like; when the traditional Chinese medicine composition provided by the invention is used for treatment, the knee joint pain is completely eliminated after the continuous treatment is carried out for 15 days, other symptoms are also cured, no recurrence is caused, and the treatment effect is obvious.
Patient 2, female, age 45, with rheumatoid arthritis, with morning stiffness symptoms, neck joint pain; by using the traditional Chinese medicine composition provided by the invention, morning stiffness symptoms are completely eliminated after 30 days of continuous treatment, neck joint pain symptoms are also cured, relapse does not occur, and the treatment effect is obvious.
The patient 3, male, 42 years old, has sprained the right foot, and then has pain symptoms frequently appearing at the ankle joint of the right foot, which causes adverse effects on the daily life; after the traditional Chinese medicine composition provided by the invention is used for continuously treating 45 days, the symptoms of right ankle joint pain completely disappear, no recurrence is caused, and the treatment effect is obvious.
In summary, according to the traditional Chinese medicine composition for treating arthralgia and the preparation method thereof provided by the embodiment of the invention, in the raw material medicinal materials of the traditional Chinese medicine composition, the kusnezoff monkshood root contains various alkaloids such as aconitine, hypaconitine, and glaucoline, and the ethanol infusion has an obvious analgesic effect, can treat joint diseases such as rheumatoid arthritis, and relieve arthralgia symptoms, and also has a certain antipyretic effect; the eupolyphaga contains various volatile oils, amino acids, steroids, phenols, organic acids, alkaloids and various trace elements necessary for human bodies, has the anticoagulation effect, can play a role in promoting blood circulation and relieving pain, is beneficial to relieving symptoms such as arthralgia caused by joint diseases and the like, and also has the effects of regulating blood fat and resisting tumors; the scorpion contains polypeptide with antiepileptic activity and analgesic activity, trimethylamine, betaine, taurine and various amino acids, has the function of resisting convulsion, is beneficial to treating rheumatism and various joint symptoms caused by rheumatism, and also has the function of resisting tumors; centipede fatty oil, cholesterol, formic acid, amino acid and other substances, similar to scorpion, have the efficacies of resisting convulsion and tumor, and simultaneously have the antifungal effect, and can also treat rheumatic diseases; the ligusticum wallichii contains various substances such as tetramethylpyrazine and loline, also contains various volatile oils, has obvious sedation, can dilate blood vessels, has the effect of activating blood, can influence cell metabolism, enhances physiological functions, also has obvious effects of easing pain and inhibiting bacteria, and can effectively relieve symptoms such as arthralgia; the kadsura pepper stem contains various components such as the piperine, the piperitone stigmasterol and the volatile oil, has better curative effect on coronary heart disease and cerebral thrombosis, also has the effects of expelling wind-damp and relieving pain, and can treat rheumatic diseases and symptoms such as arthralgia caused by the rheumatic diseases; the rose mallow contains various substances such as phenolic components, amino acids, sterol and the like, and can treat diseases such as rheumatoid arthritis, rheumatic arthralgia and the like; the herba speranskiae tuberculatae contains various components such as indazole-3-acetonitrile, kaempferol-3-glucoside, quercetin-3-glucoside, etc., has the effects of dispelling pathogenic wind, removing dampness, promoting blood circulation, and relieving pain, and can be used for treating various rheumatic diseases and arthralgia. The raw material medicines are matched with each other, and the synergistic effect is realized, so that the medicinal materials can fully exert respective beneficial effects, and the treatment effect of the product medicine on symptoms such as arthralgia and the like caused by various joint diseases is enhanced.
The preparation method comprises the steps of crushing, grinding and sieving the Wu, the ground eupolyphaga, the scorpion, the centipede, the ligusticum wallichii, the kadsura pepper stem, the radix hyperici japonici and the garden balsam stem, wherein the beneficial components in the medicinal materials can be better extracted in the subsequent steps by grinding the medicinal materials into powder, so that the treatment effect of the product medicament is enhanced, and the medicinal materials can fully exert respective beneficial effects; then adding ethanol for reflux extraction, and taking the ethanol as a solvent to extract beneficial components in the medicinal materials in a reflux extraction manner without damaging the beneficial components; then concentrating into extract, and further preparing into ointment and other finished medicines in different states, which is convenient and quick to use and is more beneficial to treatment. The whole preparation method is simple in flow, the prepared medicine can effectively relieve and treat various joint diseases, joint pain and other symptoms, the treatment effect is good, and the use is convenient and quick.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating arthralgia is characterized by comprising the following raw material components: 1-6 parts of kusnezoff monkshood root, 2-6 parts of ground beetle, 1-2 parts of scorpion, 1-2 parts of centipede, 2-6 parts of szechuan lovage rhizome, 2-8 parts of kadsura pepper stem, 5-10 parts of rose mallow flower and 2-6 parts of garden balsam stem.
2. The traditional Chinese medicine composition for treating arthralgia according to claim 1, wherein the dosage of each raw material is as follows: 3 parts of kusnezoff monkshood root, 3 parts of ground beetle, 1.6 parts of scorpion, 1.2 parts of centipede, 5 parts of szechuan lovage rhizome, 7 parts of kadsura pepper stem, 8 parts of rose mallow and 5 parts of garden balsam stem.
3. The traditional Chinese medicine composition for treating arthralgia according to claim 1, wherein the raw materials further comprise an osmotic agent in an amount of 1-2% by mass based on the total mass of the medicine.
4. The traditional Chinese medicine composition for treating joint pain according to claim 3, wherein the penetrant is laurocapram.
5. A method for preparing the Chinese medicinal composition for treating arthralgia according to any one of claims 1 to 4, which comprises the steps of: pulverizing radix Aconiti Kusnezoffii, Eupolyphaga Seu Steleophaga, Scorpio, Scolopendra, rhizoma Ligustici Chuanxiong, caulis Piperis Futokadsurae, flos Urenae Lobatae and caulis et folium Gaultheriae Yunnanensis, sieving, adding ethanol, reflux extracting, concentrating to obtain extract, and making into final product.
6. The method for preparing a Chinese medicinal composition for treating arthralgia according to claim 5, wherein the mesh size of said sieve is 120 meshes.
7. The method for preparing a Chinese medicinal composition for treating arthralgia according to claim 5, wherein the reflux extraction is performed by adding 70% ethanol in an amount 6 times the weight of the raw material drugs.
8. The method for preparing a Chinese medicinal composition for treating arthralgia according to claim 7, wherein the reflux extraction is repeated twice, and 70% ethanol, 6 times the weight of the raw material drug, is added each time, and the extraction is performed for 2 hours each time.
9. The method for preparing a Chinese medicinal composition for treating arthralgia according to claim 5, wherein the extract is concentrated to a relative density of 1.3 after the reflux extraction.
10. The method for preparing a Chinese medicinal composition for treating arthralgia according to claim 5, wherein the composition is prepared by concentrating into an extract, adding a penetrant, and making into plaster.
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