CN114601873A - Itching relieving patch prepared from spearmint and preparation method thereof - Google Patents
Itching relieving patch prepared from spearmint and preparation method thereof Download PDFInfo
- Publication number
- CN114601873A CN114601873A CN202210173137.1A CN202210173137A CN114601873A CN 114601873 A CN114601873 A CN 114601873A CN 202210173137 A CN202210173137 A CN 202210173137A CN 114601873 A CN114601873 A CN 114601873A
- Authority
- CN
- China
- Prior art keywords
- spearmint
- itching relieving
- parts
- prepared
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 48
- 230000007803 itching Effects 0.000 title claims abstract description 44
- 235000014749 Mentha crispa Nutrition 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 244000078639 Mentha spicata Species 0.000 title 1
- 244000024873 Mentha crispa Species 0.000 claims abstract description 36
- 239000000243 solution Substances 0.000 claims abstract description 27
- 238000003756 stirring Methods 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 18
- 239000011159 matrix material Substances 0.000 claims abstract description 17
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241001071917 Lithospermum Species 0.000 claims abstract description 16
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 16
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 16
- 229960001631 carbomer Drugs 0.000 claims abstract description 16
- 239000012153 distilled water Substances 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 241000972672 Phellodendron Species 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 13
- 229920001661 Chitosan Polymers 0.000 claims abstract description 11
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 11
- 235000009566 rice Nutrition 0.000 claims abstract description 11
- 235000021419 vinegar Nutrition 0.000 claims abstract description 11
- 239000000052 vinegar Substances 0.000 claims abstract description 11
- 239000011259 mixed solution Substances 0.000 claims abstract description 7
- 241000246044 Sophora flavescens Species 0.000 claims abstract description 6
- 238000000605 extraction Methods 0.000 claims abstract description 6
- 239000000706 filtrate Substances 0.000 claims abstract description 6
- 238000002791 soaking Methods 0.000 claims abstract description 6
- 238000005303 weighing Methods 0.000 claims abstract description 6
- 240000007594 Oryza sativa Species 0.000 claims abstract 3
- 241000245665 Taraxacum Species 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 3
- 208000002193 Pain Diseases 0.000 abstract description 8
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 5
- 239000003908 antipruritic agent Substances 0.000 abstract description 3
- 230000000857 drug effect Effects 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 241000209094 Oryza Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 241000218691 Cupressaceae Species 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000001769 paralizing effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an itching relieving patch prepared from spearmint and a preparation method thereof, wherein the itching relieving patch comprises the following steps: the method comprises the following steps: dissolving a proper amount of chitosan in a certain amount of rice vinegar to form gel liquid; step two: weighing spearmint, lithospermum, phellodendron, dandelion, cortex dictamni, sophora flavescens and fructus kochiae, soaking and decocting the mixture in water, and separating filtrate and filter residue to obtain a traditional Chinese medicine extracting solution; step three: adding the Chinese medicinal extractive solution into the gel solution; step four: adding medical carbomer into distilled water, and stirring to obtain matrix; step five: adding the extraction mixed solution into the prepared matrix, stirring uniformly, adding sodium hydroxide to adjust the pH value to 6.0-7.0, and stirring uniformly to obtain itching relieving gel; step six: and (3) smearing the itching relieving gel on the patch to obtain the itching relieving patch. The natural detumescence antipruritic component has the advantages of reliability and safety, suitability for both the old and the young, instant pain and itch relief by sticking, lasting drug effect guaranteed by the full moisture of the gel, and good long-acting detumescence antipruritic effect.
Description
Technical Field
The invention relates to the technical field of itching relieving patches, in particular to an itching relieving patch prepared from spearmint and a preparation method thereof.
Background
The spearmint is a name of a traditional Chinese medicinal material, has the effects of dispelling wind, regulating qi and relieving pain, can inhibit paralytic sensory nerve endings, has the effects of relieving pain and itching, is suitable for patients suffering from neuralgia, rheumatic arthralgia and skin itch, has obvious effects of relieving pain and itching after being used by some patients bitten by mosquitoes, and can reduce swelling, relieve pain, resist bacteria and diminish inflammation. The invention aims to develop an itching relieving patch which is pure natural and has long-acting pain relieving and itching relieving effects.
Disclosure of Invention
The technical problem to be solved by the invention is to provide an itching relieving patch made of spearmint and a preparation method thereof, so as to solve the problems in the background technology.
The technical problem solved by the invention is realized by adopting the following technical scheme: an itching relieving patch prepared from spearmint and a preparation method thereof comprise the following steps:
the method comprises the following steps: dissolving a proper amount of chitosan in a certain amount of rice vinegar, and uniformly stirring to form a semitransparent gel liquid;
step two: weighing a certain amount of spearmint, lithospermum, phellodendron, dandelion, cortex dictamni, sophora flavescens and kochiae, cutting, mixing to obtain a mixture, soaking the mixture in water for 40-50 min, decocting for 2-4 h, and separating filtrate and filter residue to obtain a traditional Chinese medicine extracting solution;
step three: cooling the Chinese medicinal extractive solution to 65 deg.C, adding gel solution, standing for 20-24 hr, filtering, and centrifuging to obtain extractive solution;
step four: slowly adding a certain amount of medical carbomer into distilled water, and uniformly stirring to prepare a matrix;
step five: adding the extraction mixed solution into the prepared matrix, stirring uniformly, adding sodium hydroxide to adjust the pH value to 6.0-7.0, and stirring uniformly to obtain itching relieving gel;
step six: and (3) smearing the itching relieving gel on the patch to obtain the itching relieving patch.
As a preferred embodiment of the present invention:
the weight portion ratio of the chitosan to the rice vinegar in the step one is 1-2:60, and the weight portion of the prepared gel liquid is 100.
As a preferred embodiment of the present invention:
the spearmint, the lithospermum, the golden cypress, the dandelion, the cortex dictamni, the radix sophorae flavescentis and the fructus kochiae in parts by weight are as follows: 90 parts of spearmint, 60 parts of lithospermum, 40 parts of phellodendron, 30 parts of dandelion, 30 parts of cortex dictamni, 40 parts of radix sophorae flavescentis and 50 parts of fructus kochiae.
As a preferred embodiment of the present invention:
the mixture is decocted into a first decoction liquid and a second decoction liquid, the first decoction liquid and the second decoction liquid are combined and heated and concentrated, and the weight parts of the traditional Chinese medicine extracting solution are controlled to be 700 and 900 parts.
As a preferred embodiment of the present invention:
the centrifugal rotating speed in the third step is 3000-3500 r/min.
As a preferred embodiment of the present invention:
the weight part ratio of the medical carbomer to the distilled water is 3-5:200, the medical carbomer circle and the distilled water are stirred uniformly and then need to stand for one day, and the weight part of the matrix is 250 parts.
Compared with the prior art, the invention has the beneficial effects that: the natural detumescence antipruritic component has the advantages of reliability and safety, suitability for both the old and the young, instant pain and itch relief by sticking, lasting drug effect guaranteed by the full moisture of the gel, and good long-acting detumescence antipruritic effect.
Detailed Description
The present invention is further described in order to make the technical means, the creation features, the achievement objects and the functions of the present invention easy to understand.
Example 1
An itching relieving patch prepared from spearmint and a preparation method thereof comprise the following steps:
the method comprises the following steps: dissolving a proper amount of chitosan in a certain amount of rice vinegar, and uniformly stirring to form a semitransparent gel liquid;
step two: weighing a certain amount of spearmint, lithospermum, phellodendron, dandelion, cortex dictamni, sophora flavescens and kochiae, cutting, mixing to obtain a mixture, soaking the mixture in water for 40min, decocting for 2h, and separating filtrate and filter residue to obtain a traditional Chinese medicine extracting solution;
step three: cooling the Chinese medicinal extractive solution to 65 deg.C, adding gel solution, standing for 20 hr, filtering, and centrifuging to obtain extractive solution;
step four: slowly adding a certain amount of medical carbomer into distilled water, and uniformly stirring to prepare a matrix;
step five: adding the extraction mixed solution into the prepared matrix, stirring uniformly, adding sodium hydroxide to adjust the pH value to 6.0, and stirring uniformly to obtain itching relieving gel;
step six: and (3) smearing the itching relieving gel on the patch to obtain the itching relieving patch.
The weight portion ratio of the chitosan to the rice vinegar in the step one is 1:60, and the weight portion of the prepared gel liquid is 100.
The spearmint, the lithospermum, the phellodendron, the dandelion, the cortex dictamni, the radix sophorae flavescentis and the fructus kochiae are prepared from the following raw materials in parts by weight: 90 parts of spearmint, 60 parts of lithospermum, 40 parts of phellodendron, 30 parts of dandelion, 30 parts of cortex dictamni, 40 parts of radix sophorae flavescentis and 50 parts of fructus kochiae.
And the mixture is decocted into a first decoction and a second decoction, the first decoction and the second decoction are combined and heated and concentrated, and the weight part of the traditional Chinese medicine extracting solution is controlled to be 700 parts.
The centrifugal rotating speed in the third step is 3000 r/min.
The weight portion ratio of the medical carbomer to the distilled water is 3:200, the medical carbomer circle and the distilled water are stirred uniformly and then need to stand for one day, and the weight portion of the matrix is 250 portions.
Example 2
An itching relieving patch prepared from spearmint and a preparation method thereof comprise the following steps:
the method comprises the following steps: dissolving a proper amount of chitosan in a certain amount of rice vinegar, and uniformly stirring to form a semitransparent gel liquid;
step two: weighing a certain amount of spearmint, lithospermum, phellodendron, dandelion, cortex dictamni, sophora flavescens and kochiae, cutting, mixing to obtain a mixture, soaking the mixture in water for 45min, decocting for 3h, and separating filtrate and filter residue to obtain a traditional Chinese medicine extracting solution;
step three: cooling the Chinese medicinal extractive solution to 65 deg.C, adding gel solution, standing for 22 hr, filtering, and centrifuging to obtain extractive mixed solution;
step four: slowly adding a certain amount of medical carbomer into distilled water, and uniformly stirring to prepare a matrix;
step five: adding the extraction mixed solution into the prepared matrix, stirring uniformly, adding sodium hydroxide to adjust the pH value to 6.5, and stirring uniformly to obtain itching relieving gel;
step six: and (3) smearing the itching relieving gel on the patch to obtain the itching relieving patch.
The weight portion ratio of the chitosan to the rice vinegar in the step one is 1.5:60, and the weight portion of the prepared gel liquid is 100.
The spearmint, the lithospermum, the phellodendron, the dandelion, the cortex dictamni, the radix sophorae flavescentis and the fructus kochiae are prepared from the following raw materials in parts by weight: 90 parts of spearmint, 60 parts of lithospermum, 40 parts of phellodendron, 30 parts of dandelion, 30 parts of cortex dictamni, 40 parts of radix sophorae flavescentis and 50 parts of fructus kochiae.
And the mixture is decocted into a first decoction and a second decoction, the first decoction and the second decoction are combined and heated and concentrated, and the weight part of the traditional Chinese medicine extracting solution is controlled to be 800 parts.
The centrifugal rotating speed in the third step is 3200 r/min.
The weight portion ratio of the medical carbomer to the distilled water is 4:200, the medical carbomer circle and the distilled water are stirred uniformly and then need to stand for one day, and the weight portion of the matrix is 250 portions.
Example 3
An itching relieving patch prepared from spearmint and a preparation method thereof comprise the following steps:
the method comprises the following steps: dissolving a proper amount of chitosan in a certain amount of rice vinegar, and uniformly stirring to form a semitransparent gel liquid;
step two: weighing a certain amount of spearmint, lithospermum, phellodendron, dandelion, cortex dictamni, sophora flavescens and kochiae, cutting, mixing to obtain a mixture, soaking the mixture in water for 50min, decocting for 2-4 h, and separating filtrate and filter residue to obtain a traditional Chinese medicine extracting solution;
step three: cooling the Chinese medicinal extractive solution to 65 deg.C, adding gel solution, standing for 24 hr, filtering, and centrifuging to obtain extractive solution;
step four: slowly adding a certain amount of medical carbomer into distilled water, and uniformly stirring to prepare a matrix;
step five: adding the extraction mixed solution into the prepared matrix, stirring uniformly, adding sodium hydroxide to adjust the pH value to 7.0, and stirring uniformly to obtain itching relieving gel;
step six: and (3) smearing the itching relieving gel on the patch to obtain the itching relieving patch.
The weight portion ratio of the chitosan to the rice vinegar in the step one is 2:60, and the weight portion of the prepared gel liquid is 100.
The spearmint, the lithospermum, the golden cypress, the dandelion, the cortex dictamni, the radix sophorae flavescentis and the fructus kochiae in parts by weight are as follows: 90 parts of spearmint, 60 parts of lithospermum, 40 parts of phellodendron, 30 parts of dandelion, 30 parts of cortex dictamni, 40 parts of radix sophorae flavescentis and 50 parts of fructus kochiae.
And the mixture is decocted into a first decoction and a second decoction, the first decoction and the second decoction are combined and heated and concentrated, and the weight part of the traditional Chinese medicine extracting solution is controlled to be 900 parts.
The centrifugal rotating speed in the third step is 3500 r/min.
The weight part ratio of the medical carbomer to the distilled water is 5:200, the medical carbomer circle and the distilled water are stirred uniformly and then need to stand for one day, and the weight part of the matrix is 250.
Case study analysis:
patients were screened, and patients with subjective symptoms of pruritus, pain, and swelling were treated as case patients, 50 patients who met the treatment were observed, and were applied to the affected part by an antipruritic patch 2 times a day and reviewed within 2 weeks after the treatment. The cured patients had 42 cases, 6 cases with obvious effect and 2 cases with no effect.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof. It is noted that, in this document, relational terms such as first and second, and the like, if any, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Claims (6)
1. An itching relieving patch prepared from spearmint and a preparation method thereof are characterized in that: the method comprises the following steps:
the method comprises the following steps: dissolving a proper amount of chitosan in a certain amount of rice vinegar, and uniformly stirring to form a semitransparent gel liquid;
step two: weighing a certain amount of spearmint, lithospermum, phellodendron, dandelion, cortex dictamni, sophora flavescens and kochiae, cutting, mixing to obtain a mixture, soaking the mixture in water for 40-50 min, decocting for 2-4 h, and separating filtrate and filter residue to obtain a traditional Chinese medicine extracting solution;
step three: cooling the Chinese medicinal extractive solution to 65 deg.C, adding gel solution, standing for 20-24 hr, filtering, and centrifuging to obtain extractive solution;
step four: slowly adding a certain amount of medical carbomer into distilled water, and uniformly stirring to prepare a matrix;
step five: adding the extraction mixed solution into the prepared matrix, stirring uniformly, adding sodium hydroxide to adjust the pH value to 6.0-7.0, and stirring uniformly to obtain itching relieving gel;
step six: and (3) smearing the itching relieving gel on the patch to obtain the itching relieving patch.
2. The itching relieving patch prepared from spearmint and the preparation method of the itching relieving patch prepared from spearmint according to claim 1 are characterized in that: the weight portion ratio of the chitosan to the rice vinegar in the step one is 1-2:60, and the weight portion of the prepared gel liquid is 100.
3. The itching relieving patch prepared from spearmint and the preparation method of the itching relieving patch prepared from spearmint according to claim 1 are characterized in that: the spearmint, the lithospermum, the phellodendron, the dandelion, the cortex dictamni, the radix sophorae flavescentis and the fructus kochiae are prepared from the following raw materials in parts by weight: 90 parts of spearmint, 60 parts of lithospermum, 40 parts of phellodendron, 30 parts of dandelion, 30 parts of cortex dictamni, 40 parts of radix sophorae flavescentis and 50 parts of fructus kochiae.
4. The itching relieving patch prepared from spearmint and the preparation method of the itching relieving patch prepared from spearmint according to claim 1 are characterized in that: the mixture is decocted into a first decoction liquid and a second decoction liquid, the first decoction liquid and the second decoction liquid are combined and heated and concentrated, and the weight parts of the traditional Chinese medicine extracting solution are controlled to be 700 and 900 parts.
5. The itching relieving patch prepared from spearmint and the preparation method of the itching relieving patch prepared from spearmint according to claim 1 are characterized in that: the centrifugal rotating speed in the third step is 3000-3500 r/min.
6. The itching relieving patch prepared from spearmint and the preparation method of the itching relieving patch prepared from spearmint according to claim 1 are characterized in that: the weight part ratio of the medical carbomer to the distilled water is 3-5:200, the medical carbomer circle and the distilled water are stirred uniformly and then need to stand for one day, and the weight part of the matrix is 250 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210173137.1A CN114601873A (en) | 2022-02-24 | 2022-02-24 | Itching relieving patch prepared from spearmint and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210173137.1A CN114601873A (en) | 2022-02-24 | 2022-02-24 | Itching relieving patch prepared from spearmint and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114601873A true CN114601873A (en) | 2022-06-10 |
Family
ID=81858292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210173137.1A Pending CN114601873A (en) | 2022-02-24 | 2022-02-24 | Itching relieving patch prepared from spearmint and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114601873A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784335A (en) * | 2012-08-23 | 2012-11-21 | 徐慧 | Traditional Chinese medicine compound lotion for treating urticaria papulosa and preparation method thereof |
| CN103908512A (en) * | 2013-01-08 | 2014-07-09 | 国药控股深圳中药有限公司 | Preparation methods of traditional Chinese medicine gel and traditional Chinese medicine lotion for treating dermatopathy |
| CN108434227A (en) * | 2018-05-23 | 2018-08-24 | 内蒙古恒森药业有限公司 | A kind of drug for treating tinea pedis |
| CN108888676A (en) * | 2018-09-04 | 2018-11-27 | 柳州市妇幼保健院 | A kind of Chinese medicine composition and preparation method thereof for treating eczema |
| CN110585294A (en) * | 2019-10-17 | 2019-12-20 | 覃友云 | Chinese herbal medicine spray for treating skin tinea |
-
2022
- 2022-02-24 CN CN202210173137.1A patent/CN114601873A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784335A (en) * | 2012-08-23 | 2012-11-21 | 徐慧 | Traditional Chinese medicine compound lotion for treating urticaria papulosa and preparation method thereof |
| CN103908512A (en) * | 2013-01-08 | 2014-07-09 | 国药控股深圳中药有限公司 | Preparation methods of traditional Chinese medicine gel and traditional Chinese medicine lotion for treating dermatopathy |
| CN108434227A (en) * | 2018-05-23 | 2018-08-24 | 内蒙古恒森药业有限公司 | A kind of drug for treating tinea pedis |
| CN108888676A (en) * | 2018-09-04 | 2018-11-27 | 柳州市妇幼保健院 | A kind of Chinese medicine composition and preparation method thereof for treating eczema |
| CN110585294A (en) * | 2019-10-17 | 2019-12-20 | 覃友云 | Chinese herbal medicine spray for treating skin tinea |
Non-Patent Citations (4)
| Title |
|---|
| 宁在兰: "家庭实用坐浴疗法", 《家庭医学》 * |
| 白国良: "中医药治疗慢性湿疹的临床效果探讨", 《中国现代药物应用》 * |
| 聂勇: "黄连阿胶汤辨治皮肤病初探", 《河南中医》 * |
| 闵春艳 等: "复方苦参乳膏中蛇床子素的含量考察", 《抗感染药学》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108888676A (en) | A kind of Chinese medicine composition and preparation method thereof for treating eczema | |
| CN111686147A (en) | Eucommia ulmoides extract and application thereof in treating osteoporosis | |
| CN114601873A (en) | Itching relieving patch prepared from spearmint and preparation method thereof | |
| CN102302616B (en) | Cataplasm for treating knee osteoarthritis and preparation method thereof | |
| CN1060955C (en) | Plaster for treating wound | |
| CN112294884A (en) | Plant composition capable of quickly relieving itching and pain of skin and preparation method thereof | |
| CN116870076B (en) | Anti-inflammatory analgesic traditional Chinese medicine composition and preparation method and application thereof | |
| CN111420018A (en) | Chinese herbal medicine massage essential oil composition for dredging channels and collaterals and using method | |
| CN110731992A (en) | paralysis plaster, its preparation method and paralysis plaster prepared thereby | |
| CN111265566A (en) | A Chinese medicinal composition for treating fracture, and its preparation method | |
| CN1473612A (en) | Paste for relieving swelling and alleviating pain and its producing method | |
| CN115120659B (en) | Formula and preparation method of smearing nursing ointment for traditional Chinese medicine massage therapy | |
| CN115054645B (en) | Traditional Chinese medicine composition for relieving eye fatigue and preparation method thereof | |
| CN115317582B (en) | Eye patch for improving eyesight and soothing eyes | |
| CN108969612A (en) | A kind of preparation method of novel analgesic plaster | |
| CN1171629C (en) | Chapstick and preparing method thereof | |
| CN115252754B (en) | A topical herbal composition with physical cooling and fever reducing effects, and its preparation method | |
| CN114668826A (en) | Blood circulation promoting, blood stasis removing, tendon relaxing and pain relieving liquid and preparation method thereof | |
| CN112007166A (en) | Polyisobutylene traditional Chinese medicine plaster matrix and preparation method thereof | |
| CN118320023A (en) | Traditional Chinese medicine composition and traditional Chinese medicine application for treating diabetic peripheral neuropathy | |
| CN1473611A (en) | Rheumatism paste and its preparing method | |
| CN112076259A (en) | Preparation method and application of traditional Chinese medicine ointment for treating tinea pedis | |
| CN110731996A (en) | A Chinese medicinal composition for treating rheumatic arthralgia, and its application | |
| CN105560837A (en) | Drug for treating skin injuries and preparation method thereof | |
| CN1060394C (en) | Process for preparing prescription and medicinal extract of plaster for activating meridians |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220610 |