CN115192689A - Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and traditional Chinese medicine preparation thereof - Google Patents
Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and traditional Chinese medicine preparation thereof Download PDFInfo
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- CN115192689A CN115192689A CN202210995486.1A CN202210995486A CN115192689A CN 115192689 A CN115192689 A CN 115192689A CN 202210995486 A CN202210995486 A CN 202210995486A CN 115192689 A CN115192689 A CN 115192689A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and a traditional Chinese medicine preparation thereof, and belongs to the technical field of medicines. A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 3-12 parts of unprocessed nux vomica, 3-12 parts of unprocessed radix aconiti, 2-10 parts of unprocessed rhizoma arisaematis, 2-10 parts of unprocessed rhizoma pinelliae, 2-10 parts of angelica, 2-10 parts of cortex acanthopanacis, 3-12 parts of garden balsam stem, 2-10 parts of cinnamon, 3-12 parts of ligusticum wallichii, 1-9 parts of asarum, 2-10 parts of dried ginger, 2-10 parts of safflower, 2-10 parts of eucommia bark, 1-9 parts of rhizoma cibotii and 1-9 parts of acutangular anisodus root. The traditional Chinese medicine composition disclosed by the invention fully exerts the medicine effect by utilizing a traditional Chinese medicine dialectical method and based on the monarch, minister, assistant and guide interaction relationship among the raw materials, so that the pain symptom of a patient suffering from neck, shoulder, waist and leg pain can be relieved or eliminated, and the daily activity of the patient is improved.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, application and a traditional Chinese medicine preparation thereof.
Background
Neck, shoulder, waist and leg pain is a frequently encountered disease and a common disease, and has the characteristic of repeated attack. There are many causes of pain in the neck, shoulder, waist and legs, which are related to soft tissue injury, chronic strain of soft tissue, wind-cold-dampness, allergy or immunity, and clinical symptoms include pain in the waist, intermittent claudication, radiation pain in one or both lower limbs, numbness of lower limbs, and paresthesia.
Along with the change of life style of people, the incidence rate of neck, shoulder, waist and leg pains is on the rise year by year and the trend of youthfulness. According to survey statistics, 59.1% of people in the population of 30-40 years old have cervical and lumbar diseases in 2000 samples; among the population between 50 and 60 years old, the patients account for 81%; the incidence rate of people over 60 years old is as high as 82%. The disease has high morbidity, long treatment course and easy relapse, so that severe pain and long-term dysfunction caused by the disease seriously affect the physical and mental health and the life quality of a patient, and the effective prevention and treatment of the disease is the current main task.
Western medicine considers that neck, shoulder, waist and leg pain is related to aseptic inflammation, aspirin, sulindac, nimesulide, acetaminophen, phenylbutazone and other antipyretic and analgesic medicines are mainly used for oral administration in treatment, and a closed treatment method is adopted for local skin of a pain part, so that symptoms can be temporarily relieved, but the disease is easy to recur after healing, and the dependence on medicines is enhanced. Therefore, the prevention and treatment strategies for this disease in traditional Chinese medicine are gradually paid attention.
According to the syndrome differentiation of the traditional Chinese medicine, neck, shoulder, waist and leg pain belongs to the categories of pain arthralgia, injured tendons and bone arthralgia, internal causes are mainly caused by liver and kidney deficiency, old people are weak, channels and collaterals are damaged after trauma, qi stagnation and blood stasis are caused, and external causes are mainly caused by wind-cold-dampness pathogen immersion. The middle-aged and the elderly patients suffer from hypofunction of viscera due to weakness of the elderly, long-term labor, deficiency of qi and blood, insecurity of defensive system and external defense system, and prolonged labor force exertion, which can result in damage to muscles, ligaments, fascia and joints, and cold-dampness, which can result in blood stasis in veins, qi stagnation and blood stasis.
Patent document CN107095916 discloses an external traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain, a preparation method and a use method thereof, wherein the composition comprises the following components in parts by weight: 70-90 parts of pseudo-ginseng, 25-35 parts of monkshood, 25-35 parts of kusnezoff monkshood root, 25-35 parts of borneol, 30-40 parts of dipsacus root, 30-40 parts of szechuan lovage rhizome, 15-25 parts of garden balsam stem, 15-25 parts of carpet bugle herb, 15-25 parts of frankincense, 15-25 parts of myrrh, 55-65 parts of white mustard seed, 65-75 parts of safflower, 35-45 parts of Chinese angelica, 35-45 parts of notopterygium root, 35-45 parts of doubleteeth pubescent angilica root, 35-45 parts of eucommia bark, 35-45 parts of eupolyphaga, 35-45 parts of leech, 45-55 parts of lycopodium clavatum, 45-55 parts of suberect spatholobus stem and 45-55 parts of rhizoma corydalis. The external traditional Chinese medicine composition has the main curative effect of eliminating the pain and has single curative effect. Because the daily living ability of the patient with the pain of the neck, the shoulder, the waist and the legs is affected by different degrees besides the pain, the treatment needs to eliminate the pain and improve the daily living ability of the patient, thereby treating both the symptoms and root causes of the pain of the neck, the shoulder, the waist and the legs of the patient.
The patent document with publication number CN 10739949A discloses an ointment for treating pain in neck, shoulder, waist and lower extremities, which is prepared from notopterygium root, pubescent angelica root, spatholobus stem, ligusticum wallichii, radix paeoniae rubra, clematis root, angelica, kudzu root, atractylodes rhizome, ledebouriella root, achyranthes root, tetrandra root, large-leaved gentian, drynaria rhizome, cibotium rhizome, dioscorea rhizome, astragalus root, fleece-flower root, dipsacus root, tortoise plastron, peach kernel, pawpaw, buck grass, speranskia herb, safflower, eucommia bark, acanthopanax bark, cassia twig, perilla leaf, monkshood, radix aconiti agrestis, nux vomica, frankincense, myrrh, centipede, scorpion, garter snake, earthworm, dragon's blood, banksia rose, white mustard seed, corydalis tuber, asarum, cinnamon, notoginseng, catechu, mentholum, camphor, castor bean, orange seed, sweetgum fruit, diphenhydramine hydrochloride tablet, far infrared ceramic powder, etc. The ointment has the advantages of complex raw material medicines, inaccurate and appropriate compatibility and low treatment efficiency.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to solve the technical problem of providing the traditional Chinese medicine composition for treating the neck, shoulder, waist and leg pain so as to improve the treatment effect of the neck, shoulder, waist and leg pain.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 3-12 parts of unprocessed nux vomica, 3-12 parts of unprocessed radix aconiti, 2-10 parts of unprocessed rhizoma arisaematis, 2-10 parts of unprocessed rhizoma pinelliae, 2-10 parts of angelica, 2-10 parts of cortex acanthopanacis, 3-12 parts of garden balsam stem, 2-10 parts of cinnamon, 3-12 parts of ligusticum wallichii, 1-9 parts of asarum, 2-10 parts of dried ginger, 2-10 parts of safflower, 2-10 parts of eucommia bark, 1-9 parts of rhizoma cibotii and 1-9 parts of acutangular anisodus root.
Preferably, the traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 6-9 parts of unprocessed nux vomica, 6-9 parts of unprocessed radix aconiti, 4-7 parts of unprocessed rhizoma arisaematis, 4-7 parts of unprocessed rhizoma pinelliae, 4-7 parts of angelica, 4-7 parts of cortex acanthopanacis, 6-9 parts of garden balsam stem, 4-7 parts of cinnamon, 6-9 parts of ligusticum wallichii, 3-6 parts of asarum, 4-7 parts of dried ginger, 4-7 parts of safflower, 4-7 parts of eucommia bark, 3-6 parts of rhizoma cibotii and 3-6 parts of acutangular anisodus root.
Preferably, the traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 7 parts of nux vomica, 7 parts of unprocessed radix aconiti, 6 parts of unprocessed rhizoma arisaematis, 6 parts of unprocessed rhizoma pinelliae, 6 parts of angelica, 6 parts of cortex acanthopanacis, 8 parts of garden balsam stem, 6 parts of cinnamon, 8 parts of ligusticum wallichii, 5 parts of asarum, 6 parts of dried ginger, 6 parts of safflower, 6 parts of eucommia ulmoides, 5 parts of rhizoma cibotii and 5 parts of acutangular anisodus.
Preferably, the traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain is prepared by the following method:
the method comprises the following steps: weighing raw materials, adding water, extracting effective components with ultrasonic wave, and filtering after extraction to obtain filtrate I;
step two: adding ethanol into the filtrate I, standing, and removing precipitate to obtain filtrate II;
step three: and concentrating the filtrate II, and removing ethanol to obtain a pure paste.
Preferably, 8-12ml of water is added into each gram of the bulk drugs.
Preferably, the power of the ultrasonic wave is 1000-1500W, and the ultrasonic time is 8-15min.
Preferably, the volume concentration of ethanol is 90% or more.
Preferably, the traditional Chinese medicine composition is applied to preparation of a medicine for treating neck, shoulder, waist and leg pain.
A Chinese medicinal preparation comprises the Chinese medicinal composition and pharmaceutically acceptable adjuvants.
Preferably, the auxiliary material is one or more of vanillyl butyl ether, azone and menthol.
Preferably, the traditional Chinese medicine preparation is an external preparation.
The basic characteristics of the raw material medicaments used in the invention are as follows:
raw nux vomica: dried mature seed of Strychnos nuxvomica l. Harvesting mature fruits in winter, taking out seeds, and drying in the sun. It enters liver and spleen meridians. Bitter in nature and warm in taste; it is toxic. The functional indications are as follows: unblock collaterals to alleviate pain, dissipate nodulation and resolve swelling.
Raw radix aconiti: is dried mother root of Aconitum Carmichaeli Debx of Ranunculaceae. Collected and dug in the late 6 th to the early 8 th of the month, removed the rootlets, fibrous roots and silt, and dried in the sun. It enters heart, liver, kidney and spleen meridians. Pungent, bitter and hot in nature; it is toxic. The functional indications are as follows: dispel wind and dampness, warm meridians and alleviate pain.
Rhizoma arisaematis: is a dried tuber of Arisaema erubes (wall.) Schott, a plant of Araceae. Collected in autumn and winter when stem and leaf withered, removed fibrous root and outer skin, and dried. It enters lung, liver and spleen meridians. Bitter and pungent in property and warm in nature; is toxic. The functional indications are as follows: dry dampness and resolve phlegm, dispel wind and stop convulsion, dissipate nodulation and resolve swelling.
Raw pinellia ternate: is a dried tuber of the plant Pinellia tuber of the family Araceae, pinellia ternata (thunb.) Breit. Collected in summer and autumn, cleaned, removed of outer skin and fibrous root, and dried in the sun. It enters spleen, stomach and lung meridians. Nature and taste: pungent and warm; is toxic. The functional indications are as follows: dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, relieve stuffiness and dissipate nodulation.
Chinese angelica: is dried root of Angelica sinensis (oliv.) Diels) belonging to family Umbelliferae. Removing impurities, cleaning, moistening, slicing, and drying in the sun or at low temperature. It enters liver, heart and spleen meridians. Nature and taste: sweet, pungent and warm. The functional indications are as follows: tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation.
Cortex acanthopanacis: is dried root bark of Acanthopanax gracilistylus W.W.Smith of Araliaceae. Digging root in summer and autumn, cleaning, peeling root bark, and sun drying to enter liver and kidney meridians. Pungent, bitter and warm in nature. The functional indications are as follows: dispel wind-damp, tonify liver and kidney, strengthen tendons and bones.
Garden balsam stem: is a whole plant of Speranskia tuboculata (Bunge) Baill. Collected in summer and autumn. Processing: cleaning, drying in the sun, and cutting into pieces. It enters liver and kidney meridians. Pungent, bitter and warm in nature. Has little toxicity. The functional indications are as follows: dispel wind and dampness, remove toxicity and alleviate pain.
Cinnamon: is dried bark of Cinnamomum cassia Cassia Presl of Lauraceae. Peeling in autumn, and drying in shade. It enters kidney, spleen, heart and liver meridians. Pungent and sweet in nature and flavor and big heat. The functional indications are as follows: tonify fire and strengthen yang, guide fire to the origin, dispel cold and alleviate pain, activate blood and dredge channels.
Ligusticum wallichii: is dried rhizome of Ligusticum chuanxiong Hort (or Ligusticum wallichii Franch.) belonging to Umbelliferae. Processing: removing impurities, sizing, soaking, cleaning, moistening, slicing, and drying. It enters liver, gallbladder and pericardium meridians. Pungent and warm in nature and flavor. The functional indications are as follows: activate blood and move qi, dispel wind and alleviate pain.
Asarum: is dried whole plant of Asarum heterotropoides Fr.Schmidt var.mandshuricum (Maxim.) Kitag. Processing: removing impurities, spraying clear water, slightly moistening, cutting, and drying in the shade. It enters heart, lung and kidney meridians. Pungent and warm in nature and flavor. The functional indications are as follows: dispel wind and cold, induce resuscitation and alleviate pain, warm lung and resolve retained fluid.
Dried ginger: is dried rhizome of Zingiber officinale Rosc. Collected in winter, removed fibrous root and silt, dried in the sun or dried at low temperature. It enters spleen, stomach, kidney, heart and lung meridians. Pungent and hot in nature. The functional indications are as follows: warming the middle energizer to dispel cold, restoring yang to activate collaterals, drying dampness and dissolving phlegm.
Safflower: is dried flower of Carthamus tinctorius L. It enters heart and liver meridians. Pungent and warm in nature and flavor. The functional indications are as follows: promoting blood circulation, dredging channels, removing blood stasis and relieving pain.
Eucommia ulmoides: is dried bark of Eucommia ulmoides Oliv. belonging to family Eucommiaceae. It enters liver and kidney meridians. Sweet in nature and taste, warm. The functional indications are as follows: tonify liver and kidney, strengthen tendons and bones, prevent abortion.
Rhizoma cibotii: is dried rhizome of Cibotium barometz (L.) J.Sm. It enters liver and kidney meridians. Bitter and sweet in property and warm in nature. The functional indications are as follows: tonify liver and kidney, strengthen waist and spine, dispel wind-damp.
And (3) trisection: is prepared from radix Anisodus acutangula C.Y.Wu et C.Chen of Scopolia of Solanaceae by using root, stem and leaf and seed. Pungent, bitter and warm in nature. It is toxic. The functional indications are as follows: anaesthesia, relieving pain, dispelling wind and removing dampness.
Compared with the prior art, the invention has the following beneficial effects:
1. based on the deep research on the pathogenesis of neck, shoulder, waist and leg pain, the invention considers that the main external cause of neck, shoulder, waist and leg pain is wind-cold-dampness pathogen, the main internal cause is qi stagnation and blood stasis and deficiency of vital qi, the basic pathogenesis is the invasion of wind-cold-dampness pathogen, and the channel and qi and blood are blocked and the obstruction leads to pain, so the treatment has the main principles of dredging arthralgia and relieving pain, promoting blood circulation and removing blood stasis, and tonifying liver and kidney.
2. The traditional Chinese medicine composition meets the compatibility principle of 'monarch, minister, assistant and guide', and is a monarch medicine, wherein the raw nux vomica, the raw radix aconiti, the raw rhizoma arisaematis, the raw pinellia ternate, the garden balsam stem, the asarum and the radix anisodus are matched to dispel cold and dampness, relieve arthralgia, dredge collaterals, warm channels, detoxify and dissipate stagnation, so that the channels and collaterals are unblocked, and the pain of a patient is relieved or eliminated; the Chinese angelica, the cinnamon, the ligusticum wallichii, the dried ginger and the safflower are matched to promote blood circulation and remove blood stasis, further promote qi and blood circulation and improve blood circulation, and are ministerial drugs; cortex acanthopanacis, eucommia ulmoides and rhizoma cibotii are used as adjuvant and guiding drugs on the basis of smooth channels and collaterals and qi and blood, and are supplemented with the effects of tonifying liver and kidney, strengthening tendons and bones, strengthening healthy qi, expelling evil and treating both principal and secondary aspects; the medicines are cooperated to realize the effect of relieving pain, recover health and prevent relapse.
3. The traditional Chinese medicine composition disclosed by the invention fully exerts the medicine effect by utilizing a traditional Chinese medicine dialectical method and based on the monarch, minister, assistant and guide interaction relationship among the raw materials, so that the pain symptom of a patient suffering from neck, shoulder, waist and leg pain can be relieved or eliminated, the daily life disorder of the patient is reduced, and the daily activity of the patient is improved.
4. The traditional Chinese medicine composition is extracted by combining ultrasonic extraction and alcohol precipitation, and a proper ultrasonic extraction process is adopted according to the comprehensive characteristics of the raw material medicines, the preferable ultrasonic power is 1000-1500W, and the ultrasonic time is 8-15min, so that the tissues of the raw material medicines are effectively damaged, the extraction efficiency of the active ingredients is improved, and the medicine effect is enhanced; on the basis of ultrasonic extraction, the invention adopts alcohol precipitation to remove impurities, the temperature of the alcohol precipitation is preferably below 20 ℃, the volume concentration of the alcohol is above 90%, the time of the alcohol precipitation is above 24 hours, the addition amount of the alcohol is 2-3 times of the volume of the filtrate, under the conditions, the precipitation speed is moderate, excessive coalescence or bulk precipitation is not generated, so that the components such as protein, polysaccharide and the like in the filtrate are more fully removed, the purity of the effective components of the liquid medicine is higher, and the liquid medicine is more favorable for storage and absorption of skin.
5. The traditional Chinese medicine preparation is prepared by adding pharmaceutically acceptable auxiliary materials into a traditional Chinese medicine composition, wherein the auxiliary materials are preferably one or more than two of vanillyl butyl ether, azone and menthol, and 3.5-4.5g, preferably 4g, of the auxiliary materials are added into per 100ml of the pure paste; the auxiliary materials are more preferably a composition of vanillyl butyl ether, azone and menthol, and the mass ratio of the vanillyl butyl ether to the azone to the menthol is 1: (1.5-2.5): (0.8-1.2) to accelerate the absorption of the liquid medicine, promote local blood circulation and realize more remarkable treatment effect, wherein the vanillyl butyl ether can generate mild and lasting heat source effect after acting on the skin and accelerate local microcirculation; azone is a common skin penetration enhancer to promote the drug effect to penetrate into the skin of an affected part; the menthol has fragrance, and has effects of relieving inflammation, relieving pain and promoting blood circulation; the three components are cooperated with each other, so that the absorption effect of the skin of the affected part on the liquid medicine can be accelerated, the internal circulation is enhanced, the medicinal effect can play a more remarkable role in a shorter time, the utilization of the medicine is enhanced, and the curative effect is improved.
Detailed Description
In order to better understand the present invention, the following examples are further provided to clearly illustrate the contents of the present invention, but the contents of the present invention are not limited to the following examples. In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the present invention. It will be apparent, however, to one skilled in the art, that the present invention may be practiced without one or more of these specific details.
In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.
Unless otherwise specified, all starting materials are derived from commercially available products, and if not specified, contain no other components not specifically specified except for unavoidable impurities.
Example 1: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 7 parts of nux vomica, 7 parts of unprocessed radix aconiti, 6 parts of unprocessed rhizoma arisaematis, 6 parts of unprocessed pinellia ternate, 6 parts of angelica, 6 parts of cortex acanthopanacis, 8 parts of garden balsam stem, 6 parts of cinnamon, 8 parts of ligusticum wallichii, 5 parts of asarum, 6 parts of dried ginger, 6 parts of safflower, 6 parts of eucommia ulmoides, 5 parts of rhizoma cibotii and 5 parts of acutangular anisodus root.
Weighing the raw material medicines in parts by weight, adding water, adding 10ml of water into each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.5 times of the volume of the first filtrate, standing for 48 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 80 deg.C, and removing ethanol to obtain pure extract.
Wherein the power of the ultrasonic wave is 1250W, and the time is 10min.
The relative density of the fine paste was 1.17.
Example 2: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 6 parts of nux vomica, 6 parts of unprocessed radix aconiti, 4 parts of unprocessed rhizoma arisaematis, 4 parts of unprocessed pinellia ternate, 4 parts of angelica, 4 parts of cortex acanthopanacis, 6 parts of garden balsam stem, 4 parts of cinnamon, 6 parts of ligusticum wallichii, 3 parts of asarum, 4 parts of dried ginger, 4 parts of safflower, 4 parts of eucommia ulmoides, 3 parts of rhizoma cibotii and 3 parts of acutangular anisodus root.
Weighing the raw material medicines in parts by weight, adding water, adding 8ml of water in each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by using gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2 times of the volume of the first filtrate, standing for 48 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 75 deg.C, removing ethanol to obtain refined pure paste.
Wherein the power of the ultrasonic wave is 1500W, and the ultrasonic time is 8min.
The relative density of the fine paste was 1.15.
Example 3: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 9 parts of nux vomica, 9 parts of unprocessed radix aconiti, 5 parts of unprocessed rhizoma arisaematis, 5 parts of unprocessed rhizoma pinelliae, 5 parts of angelica, 5 parts of cortex acanthopanacis, 9 parts of garden balsam stem, 5 parts of cinnamon, 9 parts of ligusticum wallichii, 4 parts of asarum, 5 parts of dried ginger, 5 parts of safflower, 5 parts of eucommia ulmoides, 4 parts of rhizoma cibotii and 4 parts of acutangular anisodus root.
Weighing the raw material medicines in parts by weight, adding water, adding 9ml of water in each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by using gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.3 times of the volume of the first filtrate, standing for 32 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 80 deg.C, and removing ethanol to obtain pure extract.
Wherein the power of the ultrasonic wave is 1300W, and the ultrasonic time is 12min.
The relative density of the fine paste was 1.18.
Example 4: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 8 parts of nux vomica, 8 parts of unprocessed radix aconiti, 7 parts of unprocessed rhizoma arisaematis, 7 parts of unprocessed rhizoma pinelliae, 7 parts of angelica, 7 parts of cortex acanthopanacis, 7 parts of garden balsam stem, 7 parts of cinnamon, 8 parts of ligusticum wallichii, 6 parts of asarum, 7 parts of dried ginger, 7 parts of safflower, 7 parts of eucommia ulmoides, 6 parts of rhizoma cibotii and 6 parts of acutangular anisodus root.
Weighing the raw material medicines in parts by weight, adding water, adding 10ml of water in each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by using gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.5 times of the volume of the first filtrate, standing for 40 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 85 deg.C, removing ethanol to obtain refined pure paste.
Wherein the power of the ultrasonic wave is 1000W, and the ultrasonic time is 15min.
The relative density of the fine paste was 1.20.
Example 5: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 3 parts of nux vomica, 3 parts of unprocessed radix aconiti, 2 parts of unprocessed rhizoma arisaematis, 2 parts of unprocessed rhizoma pinelliae, 2 parts of angelica, 2 parts of cortex acanthopanacis, 2 parts of garden balsam stem, 2 parts of cinnamon, 3 parts of ligusticum wallichii, 1 part of asarum, 2 parts of dried ginger, 2 parts of safflower, 2 parts of eucommia ulmoides, 1 part of rhizoma cibotii and 1 part of acutangular anisodus.
Weighing the raw material medicines in parts by weight, adding water, adding 12ml of water in each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by using gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 3 times of the volume of the first filtrate, standing for 42 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 80 deg.C, and removing ethanol to obtain pure extract.
Wherein the power of the ultrasonic wave is 1400W, and the ultrasonic time is 10min.
The relative density of the fine paste was 1.16.
Example 6: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 4 parts of nux vomica, 4 parts of unprocessed radix aconiti, 3 parts of unprocessed rhizoma arisaematis, 3 parts of unprocessed rhizoma pinelliae, 3 parts of angelica, 3 parts of cortex acanthopanacis, 3 parts of garden balsam stem, 3 parts of cinnamon, 4 parts of ligusticum wallichii, 2 parts of asarum, 3 parts of dried ginger, 3 parts of safflower, 3 parts of eucommia ulmoides, 2 parts of rhizoma cibotii and 2 parts of acutangular anisodus.
Weighing the raw material medicines in parts by weight, adding water, adding 9ml of water in each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by using gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2 times of the volume of the first filtrate, standing for 24 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 80 deg.C, removing ethanol to obtain refined pure paste.
Wherein the power of the ultrasonic wave is 1500W, and the ultrasonic time is 15min.
The relative density of the fine paste was 1.17.
Example 7: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 10 parts of nux vomica, 10 parts of unprocessed radix aconiti, 8 parts of unprocessed rhizoma arisaematis, 8 parts of unprocessed rhizoma pinelliae, 8 parts of angelica, 8 parts of cortex acanthopanacis, 10 parts of garden balsam stem, 8 parts of cinnamon, 10 parts of ligusticum wallichii, 7 parts of asarum, 8 parts of dried ginger, 8 parts of safflower, 8 parts of eucommia ulmoides, 7 parts of rhizoma cibotii and 7 parts of acutangular anisodus root.
Weighing the raw material medicines in parts by weight, adding water, adding 10ml of water in each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by using gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.6 times of the volume of the first filtrate, standing for 30 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 80 deg.C, and removing ethanol to obtain pure extract.
Wherein the power of the ultrasonic wave is 1300W, and the ultrasonic time is 12min.
The relative density of the fine paste was 1.15.
Example 8: preparation of Chinese medicinal composition
A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain comprises the following raw material medicines in parts by weight: 12 parts of nux vomica, 12 parts of unprocessed radix aconiti, 10 parts of unprocessed rhizoma arisaematis, 10 parts of unprocessed rhizoma pinelliae, 10 parts of angelica, 10 parts of cortex acanthopanacis, 12 parts of garden balsam stem, 10 parts of cinnamon, 12 parts of ligusticum wallichii, 9 parts of asarum, 10 parts of dried ginger, 10 parts of safflower, 10 parts of eucommia ulmoides, 9 parts of rhizoma cibotii and 9 parts of acutangular anisodus root.
Weighing the raw material medicines in parts by weight, adding water, adding 10ml of water in each gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by using gauze after extraction to obtain a first filtrate; adding 95% ethanol into the first filtrate, wherein the addition amount of the ethanol is 2.5 times of the volume of the first filtrate, standing for 48 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 80 deg.C, removing ethanol to obtain refined pure paste.
Wherein the power of the ultrasonic wave is 1200W, and the ultrasonic time is 12min.
The relative density of the fine paste was 1.18.
Example 9: preparation of Chinese medicinal preparation
Providing the fine pure cream prepared in the example 1, vanillyl butyl ether, azone and menthol, measuring 100ml of the fine pure cream, adding 1g of vanillyl butyl ether, 2g of azone and 1g of menthol, and uniformly mixing to obtain the preparation.
Example 10: preparation of Chinese medicinal preparation
Providing the fine pure cream prepared in the example 2, vanillyl butyl ether, azone and menthol, measuring 100ml of the fine pure cream, adding 1g of vanillyl butyl ether, 1.5g of azone and 1.2g of menthol, and uniformly mixing to obtain the preparation.
Example 11: preparation of Chinese medicinal preparation
Providing the fine pure cream prepared in the example 3, vanillyl butyl ether, azone and menthol, measuring 100ml of the fine pure cream, adding 1g of vanillyl butyl ether, 2.5g of azone and 0.8g of menthol, and uniformly mixing to obtain the preparation.
Example 12: preparation of Chinese medicinal preparation
Providing the fine paste, the vanillyl butyl ether and the azone prepared in the example 4, measuring 100ml of the fine paste, adding 1g of the vanillyl butyl ether and 3g of the azone, and uniformly mixing to obtain the preparation.
Example 13: preparation of Chinese medicinal preparation
Providing the fine paste and azone prepared in example 5, weighing 100ml of the fine paste, adding 3.5g azone, and mixing well to obtain the preparation.
Example 14: preparation of Chinese medicinal preparation
Providing the fine pure cream, the azone and the menthol prepared in the example 6, measuring 100ml of the fine pure cream, adding 2.5g of the azone and 1g of the menthol, and uniformly mixing to obtain the preparation.
Comparative example 1
Weighing the same raw materials as in example 1, adding water, adding 12ml of water to each gram of raw materials, decocting with strong fire (180 ℃) for 30min, filtering with gauze to remove residues, decocting the filtrate with slow fire (100 ℃) for 2h, standing and cooling to obtain the pure paste.
The relative density of the fine paste was 1.15.
Comparative example 2
Weighing the same raw material medicines as in example 1, adding water, adding 15ml of water per gram of raw material medicines, extracting effective components by ultrasonic waves, and filtering by gauze after extraction to obtain a first filtrate; adding 75% ethanol into the first filtrate, wherein the addition amount of the ethanol is 4 times of the volume of the first filtrate, standing for 48 hours at 20 ℃, and removing precipitates to obtain a second filtrate; concentrating the filtrate II at 80 deg.C, and removing ethanol to obtain pure extract.
Wherein the power of the ultrasonic wave is 900W, and the time is 20min.
The relative density of the fine paste was 1.16.
Effect case 1: acute toxicity and irritation test of skin
1.1 acute toxicity test on skin: taking 24 healthy white rabbits with the weight of 1.8-2.0kg and the male and female halves, randomly dividing the rabbits into a complete skin group and a damaged skin group according to the weight, wherein each group is provided with two parallel rabbits, and each group is provided with 3 rabbits.
Complete skin group: 24h before the experiment, the hair on the left side and the right side of the back of the tested rabbit is shaved by a pair of scissors and a shaver for about 4cm multiplied by 5cm, so that the skin is ensured to be complete and not damaged.
Group of damaged skin: 24h before the experiment, the hair on the left side and the right side of the back of the tested rabbit is shaved by about 4cm multiplied by 5cm by a scissors and a shaver respectively, and after a tested area is disinfected, the skin is slightly lacerated by a five-blade knife until mild bleeding is achieved.
2g of the fine paste prepared in example 1 was applied to the skin of a rabbit for 24 hours, and after the completion of the experiment, the remaining test substance was washed away with warm water. And observing the change of the skin, hair, eyes and mucosa of the rabbit at 1h, 24h, 48h and 72h to 7d after removing the test object, and the general toxic manifestation and death condition of respiration, central nervous system, limb activity and the like.
2g of the Chinese medicinal preparation prepared in example 9 was applied to the skin of a rabbit for 24 hours, and after the completion of the experiment, the residual test substance was washed away with warm water. And observing the change of the skin, hair, eyes and mucosa of the rabbit at 1h, 24h, 48h and 72h to 7d after removing the test object, and the general toxic manifestation and death condition of respiration, central nervous system, limb activity and the like.
The experimental results are as follows: in the observation period of 7d, the rabbits move freely, no abnormality is found in mental state, appetite and defecation, and the rabbits do not die. The fine paste prepared in example 1 and the Chinese medicinal preparation prepared in example 9 do not cause acute toxic reaction when applied to intact and damaged skin of rabbits.
1.2 acute skin irritation test: taking 24 healthy white rabbits with the weight of 1.8-2.0kg and the male and female halves, randomly dividing the rabbits into a complete skin group and a damaged skin group according to the weight, wherein each group is provided with two parallel rabbits, and each group is provided with 3 rabbits.
Complete skin group: 24h before the experiment, the hair on the two sides of the spine of the tested rabbit is shaved by a pair of scissors and a shaver by an area of about 5cm multiplied by 10cm respectively, so as to ensure the skin to be complete and not damaged.
Group of damaged skin: 24h before the experiment, the hair on the two sides of the spine of the tested rabbit is shaved by about 5cm multiplied by 10cm by using scissors and a shaver, and after the tested area is disinfected, the skin is slightly scratched by using a five-blade knife until mild bleeding is achieved.
2g of the fine paste prepared in example 1 was applied to the skin of a rabbit for 5 hours, and after the completion of the experiment, the remaining test substance was removed with warm water. And observing the skin reaction of the smearing part at 1h, 24h, 48h and 72h after the test substance is removed.
2g of the Chinese medicinal preparation prepared in example 9 was applied to the skin of a rabbit for 5 hours, and after completion of the experiment, the residual test substance was removed with warm water. And observing the skin reaction of the smearing part at 1h, 24h, 48h and 72h after the test substance is removed.
The experimental results are as follows: no irritation reaction such as erythema, edema and the like is seen on the skin of the tested area of the intact skin group, and no irritation is caused to the intact skin of the rabbits. The broken skin group started barely visible erythema and resolved within 12 hours without edema and other irritation reactions.
Effect case 2: clinical test of treating neck, shoulder, waist and leg pain by using traditional Chinese medicine composition
1 data and method
1.1 general data 160 patients with neck, shoulder, waist and leg pain, who were treated between 12 months 15 days of 2021 and 6 months 30 days of 2022, were selected from Nanzhanghuakang hospital and divided into 32 cases, each of which was a control group, an observation 1 group, an observation 2 group, a comparison 1 group and a comparison 2 group, by a random numerical table method. In the control group, 17 men and 15 women had their ages of 31-62 years. 19 men and 13 women in group 1 were observed, age 35-63 years. In the observation group 2, 18 men and 14 women were observed, and the age was 30-60 years. In comparative group 1, 18 men and 14 women were aged 32-60 years. 16 men and 16 women in the comparative group 2 were aged 34 to 61 years. The general data comparison of five patients shows that the difference is not statistically significant (P > 0.05) and is comparable.
1.2 inclusion and exclusion criteria
1.2.1 inclusion criteria (1) patients have symptoms of stiffness of waist and back, soreness and discomfort, needle prickling, local tension, tightness and stiffness; (2) patients understand the study and sign informed consent.
1.2.2 exclusion criteria (1) incorporation of important organ dysfunction; (2) the presence of mental illness; (3) the study was withdrawn midway.
1.3 methods
1.3.1 the patients in the control group receive the traditional Chinese medicine acupuncture and moxibustion treatment, aiming at the patients with neck pain and shoulder pain, medical staff cross left and right to pick points, including Yangxi, hegu, quchi and Fengchi, and the patients are confirmed to take the needles immediately after producing the needle feeling and do not leave the needles for treatment for 1 time/day; aiming at lumbago patients, medical staff select points of lumbago and backache, including Huan tiao, weizhong, yanglingquan, shenshu, chengfu and Jiexi, and confirm that patients have needle sensation and then take out the needle immediately without leaving the needle, and the treatment is carried out for 1 time/day; aiming at patients with knee pain, medical staff take knee pain acupoints, and after confirming that patients have needle sensation, the patients immediately take out the needles without leaving the needles, and the treatment is carried out for 1 time per day.
1.3.2 observe that 1 group of patients receive the treatment of the comprehensive traditional Chinese medicine scheme, and medical staff carry out external treatment on the patients on the basis of acupuncture treatment. After the acupuncture and moxibustion is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription for external use is the refined pure ointment prepared in example 1, and the dosage is 1.5g/100cm 2 The preparation is applied to affected part, and is gently massaged for absorption, 3 times daily, 10 days for 1 treatment course, and 2 treatment courses.
1.3.3 observe that 2 groups of patients receive the treatment of the comprehensive traditional Chinese medicine scheme, and medical staff carry out external treatment on the patients on the basis of acupuncture treatment. After the acupuncture and moxibustion is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription for external treatment is the traditional Chinese medicine preparation prepared in the example 9, and the dosage is 1.5g/100cm 2 The preparation is applied to the affected part, and gently massaged for complete absorption, 3 times per day, 10 days for 1 treatment course, and 2 treatment courses.
1.3.4 contrast group 1 patients were treated with the overall regimen of TCM and were paramedically treatedThe personnel carry out external treatment for patients on the basis of acupuncture treatment. After the acupuncture and moxibustion is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription for external treatment is the refined pure paste prepared in comparative example 1, 1.5g/100cm for each time 2 The preparation is applied to affected part, and is applied by applying the ointment on affected part, and gently massaging for complete absorption, 3 times daily, 10 days for 1 treatment course, and 2 treatment courses.
1.3.5 contrast 2 groups of patients received the treatment of the comprehensive traditional Chinese medicine scheme, and medical staff performed external treatment on the patients on the basis of acupuncture treatment. After the acupuncture and moxibustion is finished, no adverse reaction is observed, and then external treatment is carried out. The prescription for external treatment is the refined pure paste prepared in comparative example 2, 1.5g/100cm for each time 2 The preparation is applied to affected part, and is applied by applying the ointment on affected part, and gently massaging for complete absorption, 3 times daily, 10 days for 1 treatment course, and 2 treatment courses.
1.4 Observation index and judgment Standard
1.4.1 comparison of the therapeutic Effect of two groups of patients
The treatment effect is divided into healing, obvious effect and effectiveness. And (3) healing: the pain symptom disappears, the activities of the waist, the legs and the cervical vertebra are normal, and the recurrence is not seen; the effect is shown: the pain symptom is improved, the moving range of the waist, the legs and the cervical vertebra is enlarged, and the movement is slightly limited; the method has the following advantages: the pain symptoms are not improved, and the activities of the waist, the legs and the cervical vertebra are obviously limited. Treatment significant efficiency = (recovery + significant)/total number of cases × 100%.
1.4.2 comparing VAS scores of two groups of patients
Neck, shoulder, waist and leg pain performances before and after treatment are evaluated through a VAS scale, wherein the grade of 0 represents no pain performance, the grade of 3 represents that slight pain exists, the grade of 4-6 represents that the pain has certain influence on normal learning life, and the grade of 7-10 represents that the pain is difficult to tolerate.
1.4.3 comparing ADL scores of two groups of patients
The assessment is made by ADL scale, a score of >60 indicates that the patient is essentially self-care in life; the score of 40-60 indicates that the patient needs help in life and has moderate dysfunction; a score of <40 indicates that the patient is strongly life dependent and has severe dysfunction.
1.5 statistical methods
Statistical analysis was performed using SPSS17.0 statistical software. The data are measured as mean + -standard deviation
Representing, adopting t test; the count data are expressed in terms of rate (%), using χ 2 And (6) checking. P<0.05 indicates that the difference is statistically significant.
2 results
2.1 comparison of the therapeutic effects of two groups of patients
Note: compared with the control group, the compound of the formula, * p is less than 0.05; in comparison with the comparative group 1, △ p is less than 0.05; in comparison with the comparative group 2, ☆ P＜0.05。
from the above results, the treatment significant efficiency of the patients in the observation group 1 and the observation group 2 is higher than that of the control group, and the difference has statistical significance (P < 0.05); the treatment significant efficiency of the patients in the observation group 1 and the observation group 2 is higher than that in the comparison group 1, and the differences have statistical significance (P is less than 0.05); the treatment efficiency of the patients in the observation group 1 and the observation group 2 is higher than that in the comparison group 2, and the difference has statistical significance (P < 0.05). The treatment effect of the patients in the observation group 2 is higher than that of the patients in the observation group 1, and the auxiliary materials used in the invention are beneficial to improving the treatment effect of the traditional Chinese medicine composition on neck, shoulder, waist and leg pain.
2.2 comparison of VAS scores in two groups of patients
Note: compared with the control group, the compound is added, * p is less than 0.05; in comparison with the comparative group 1, △ p is less than 0.05; in comparison with the comparative group 2, ☆ P＜0.05。
comparison of VAS scores for five patients before treatment, differences were not statistically significant (P > 0.05).
After treatment, patients in observation 1 and observation 2 both had lower VAS scores than the control group, with statistical significance for the difference (P < 0.05); the VAS scores of the patients in both observation 1 and observation 2 groups were lower than that in the control 1 group, and the differences were statistically significant (P < 0.05); the VAS scores of the patients in both observation 1 and observation 2 groups were lower than those in the control 2 group, and the differences were statistically significant (P < 0.05). The VAS scores of the patients in the observation group 2 are lower than those of the patients in the observation group 1, which shows that the auxiliary materials used in the invention are beneficial to relieving the pain of neck, shoulder, waist and leg pains. The ADL score of patients in comparative group 1 was lower than that of the control group, and the difference was not statistically significant (P > 0.05). The ADL score of the patients in the comparative 2 group was lower than that of the control group, and the difference was not statistically significant (P > 0.05).
2.3 ADL score comparison of two groups of patients
Note: compared with the control group, the compound is added, * p is less than 0.05; in comparison with the comparative group 1, △ p is less than 0.05; in comparison with the comparative group 2, ☆ P＜0.05。
before treatment, five groups of patients had no statistical significance for the comparison of ADL scores (P > 0.05).
After treatment, patients in observation group 1 and observation group 2 had higher ADL scores than the control group, and the difference was statistically significant (P < 0.05); the ADL scores of the patients in the observation 1 group and the observation 2 group are higher than those in the comparison 1 group, and the differences have statistical significance (P < 0.05); the ADL scores of patients in observation 1 and observation 2 were higher than those in control 2, and the differences were statistically significant (P < 0.05). The ADL scores of the patients in the observation group 2 are higher than those of the patients in the observation group 1, which shows that the auxiliary materials used in the invention are beneficial to enhancing the treatment effect of the patients and reducing the normal life disorders of the patients. The ADL score of the patients in comparative group 1 was higher than that of the control group, and the difference was not statistically significant (P > 0.05). The ADL score of the patients in the comparative group 2 was higher than that in the control group, and the difference was not statistically significant (P > 0.05).
Discussion of 3
Neck, shoulder, waist and leg pain is a pain symptom which is shown in the neck, shoulder, waist and leg parts, has no great influence on the life, work and study of a patient in the early stage, has continuous development of diseases in the later stage, has serious influence on health and life quality, reduces normal social activities of the patient, deteriorates physical activity, lowers emotion and lowers self-confidence. The serious patient may be paralyzed and lose all the labor capacity, which causes serious burden to the society and families. Therefore, the patients with neck, shoulder, waist and leg pain should pay attention to the early stage of mild symptoms, and the treatment should be carried out in time to ensure the early recovery.
Based on the deep research on the pathogenesis of neck, shoulder, waist and leg pain, the inventor believes that the basic pathogenesis of the disease is the invasion of wind-cold-dampness, which causes the obstruction of channels and collaterals and qi and blood and leads to pain, so the treatment should be mainly based on the principles of removing obstruction of qi to relieve pain, promoting blood circulation to remove blood stasis, tonifying liver and kidney. The traditional Chinese medicine composition disclosed by the invention has the advantages that the raw nux vomica, the raw radix aconiti, the raw rhizoma arisaematis, the raw pinellia ternate, the garden balsam stem, the asarum and the radix anisodii acutanguli are matched to relieve the arthralgia, so that a patient is in a painless state, channels and collaterals are dredged by virtue of the medicine effect, qi and blood are dredged under the assistance of the angelica, the cinnamon, the ligusticum wallichii, the dried ginger and the safflower, the conditioning of the channels and the qi and blood state of the patient is realized, on the basis, the cortex acanthopanacis, the eucommia ulmoides and the rhizoma cibotii are matched, the liver and kidney are tonified, the bones and muscles are strengthened, the healthy qi is strengthened, the evil is caused, the simultaneous treatment of the symptoms and root causes of neck, shoulder, waist and leg pain is realized, and the remarkable curative effect is obtained. The traditional Chinese medicine comprehensive treatment is carried out on the patients with neck, shoulder, waist and leg pain, the pain symptoms can be obviously improved, a better treatment effect is obtained, the daily activity of the patients is improved, and the traditional Chinese medicine comprehensive treatment has a certain application value.
Finally, the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting, and other modifications or equivalent substitutions made by the technical solutions of the present invention by those of ordinary skill in the art should be covered within the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain is characterized in that: the raw material medicaments comprise the following components in part by weight: 3-12 parts of unprocessed nux vomica, 3-12 parts of unprocessed radix aconiti, 2-10 parts of unprocessed rhizoma arisaematis, 2-10 parts of unprocessed rhizoma pinelliae, 2-10 parts of angelica, 2-10 parts of cortex acanthopanacis, 3-12 parts of garden balsam stem, 2-10 parts of cinnamon, 3-12 parts of ligusticum wallichii, 1-9 parts of asarum, 2-10 parts of dried ginger, 2-10 parts of safflower, 2-10 parts of eucommia bark, 1-9 parts of rhizoma cibotii and 1-9 parts of acutangular anisodus root.
2. The traditional Chinese medicine composition for treating pain in the neck, shoulders, waist and legs as claimed in claim 1, wherein: the raw material medicaments comprise the following components in part by weight: 6-9 parts of raw nux vomica, 6-9 parts of raw radix aconiti, 4-7 parts of raw rhizoma arisaematis, 4-7 parts of raw pinellia ternate, 4-7 parts of angelica sinensis, 4-7 parts of cortex acanthopanacis, 6-9 parts of garden balsam stem, 4-7 parts of cinnamon, 6-9 parts of ligusticum wallichii, 3-6 parts of asarum, 4-7 parts of rhizoma zingiberis, 4-7 parts of safflower carthamus, 4-7 parts of eucommia ulmoides, 3-6 parts of rhizoma cibotii and 3-6 parts of acutangular anisodus root.
3. The traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain according to claim 2, wherein: the raw material medicaments comprise the following components in parts by weight: 7 parts of nux vomica, 7 parts of unprocessed radix aconiti, 6 parts of unprocessed rhizoma arisaematis, 6 parts of unprocessed rhizoma pinelliae, 6 parts of angelica, 6 parts of cortex acanthopanacis, 8 parts of garden balsam stem, 6 parts of cinnamon, 8 parts of ligusticum wallichii, 5 parts of asarum, 6 parts of dried ginger, 6 parts of safflower, 6 parts of eucommia ulmoides, 5 parts of rhizoma cibotii and 5 parts of acutangular anisodus.
4. The Chinese medicinal composition for treating pain in the neck, the shoulders, the waist and the legs as claimed in claim 1, 2 or 3, wherein: the preparation method comprises the following steps:
the method comprises the following steps: weighing raw materials, adding water, extracting effective components with ultrasonic wave, and filtering after extraction to obtain filtrate I;
step two: adding ethanol into the filtrate I, standing, and removing precipitate to obtain filtrate II;
step three: and concentrating the filtrate II, and removing ethanol to obtain a pure paste.
5. The Chinese medicinal composition for treating pain in the neck, the shoulders, the waist and the legs of claim 4, wherein: adding 8-12ml of water into each gram of the raw material medicines.
6. The Chinese medicinal composition for treating pain in the neck, the shoulders, the waist and the legs as claimed in claim 5, wherein: the power of the ultrasonic wave is 1000-1500W, and the ultrasonic time is 8-15min.
7. The Chinese medicinal composition for treating pain in the neck, the shoulders, the waist and the legs as claimed in claim 6, wherein: the volume concentration of the ethanol is more than 90%.
8. The use of the Chinese medicinal composition for the treatment of pain in the neck, shoulder, waist and leg of any one of claims 1-7 in the preparation of a medicament for the treatment of pain in the neck, shoulder, waist and leg.
9. A Chinese medicinal preparation comprising the Chinese medicinal composition of any one of claims 1-7 and pharmaceutically acceptable adjuvants.
10. The traditional Chinese medicine preparation according to claim 9, characterized in that: the auxiliary material is one or more of vanillyl butyl ether, azone and menthol.
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| CN107095916A (en) * | 2017-07-02 | 2017-08-29 | 陈首名 | Treat external medicine composition of neck-shoulder pain, lumbago and leg pain and preparation method thereof and application method |
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| CN109908245A (en) * | 2019-04-28 | 2019-06-21 | 宋少军 | It is a kind of for treating the Chinese medicine composition of neck-shoulder pain, lumbago and leg pain disease |
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| CN107095916A (en) * | 2017-07-02 | 2017-08-29 | 陈首名 | Treat external medicine composition of neck-shoulder pain, lumbago and leg pain and preparation method thereof and application method |
| CN107397949A (en) * | 2017-07-15 | 2017-11-28 | 长沙天卓生物科技有限公司 | A kind of ointment for treating neck-shoulder pain, lumbago and leg pain and preparation method thereof |
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