CN116712498A - Traditional Chinese medicine raw material composition, pharmaceutical composition and application thereof - Google Patents
Traditional Chinese medicine raw material composition, pharmaceutical composition and application thereof Download PDFInfo
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- CN116712498A CN116712498A CN202310667759.4A CN202310667759A CN116712498A CN 116712498 A CN116712498 A CN 116712498A CN 202310667759 A CN202310667759 A CN 202310667759A CN 116712498 A CN116712498 A CN 116712498A
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- chinese medicine
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Abstract
Provides a traditional Chinese medicine raw material composition, a pharmaceutical composition and application thereof. The traditional Chinese medicine raw material composition comprises the following active ingredients in parts by weight: 10-30 parts of selfheal; at least one of 3-30 parts of semen vaccariae, 9-40 parts of caulis spatholobi, 6-30 parts of roasted rhizoma cyperi, 3-20 parts of semen citri reticulatae and 10-30 parts of dandelion; at least one of 2-20 parts of liquorice and 6-20 parts of fructus cnidii; 3-30 parts of eupatorium; and optionally at least one of 3-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia. The traditional Chinese medicine raw material composition and the pharmaceutical composition are accurate in compatibility, and can effectively treat diseases such as mastitis, hyperplasia of mammary glands, breast nodules or galactocele. In addition, the traditional Chinese medicine raw material composition and the pharmaceutical composition can effectively improve clinical symptoms of patients and life quality, and have no obvious adverse reaction.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine raw material composition for treating breast diseases, a pharmaceutical composition and application thereof.
Background
Breast diseases belong to benign diseases of the breast, and the incidence rate thereof has been on the rise in recent years. The advanced age is between 20 and 40 years and more than 50% of patients are young, unfounded females.
Mammary gland diseases including mastitis and hyperplasia of mammary glands are common and frequent diseases of women, are well developed in women aged 30-50 years, often appear or aggravate along with menstrual discharge or bad emotion, and are related to menstrual history, inoculation history, lactation history, contraceptive administration history, dietary structure and social psychological factors, and the main symptoms are as follows: 1. breast pain; 2. a lump in the breast; 3. mammary gland overflow.
The traditional Chinese medicine considers that the nipple belongs to the branch of the liver meridian, the breast is the circulation of the stomach meridian, the kidney meridian enters the breast, and the breast distending pain during the menstruation has close relation with the liver, the kidney and the stomach. "surgical Authence" cloud: the liver meridian of nipple jueyin belongs to the stomach meridian of breast Yangming, and the cloud: depression hurts liver, thinking hurts spleen, and people who want to feel heart and want to feel hard feel, cause distension and astringency of channels and collaterals, coalesce and nucleate, just like bean big, gradually get chess pieces. Therefore, the breast diseases have a large relationship with liver and spleen, and also have a very close relationship with kidney, stomach and thoroughfare vessels, and the pathogenesis of the breast diseases is that the qi and blood of the breast are not smooth, and the breast is not general; or malnutrition of the milk collaterals, pain due to lack of nourishment.
The principle of treating the breast diseases is to reduce the wound of the patient as much as possible on the basis of the same curative effect. However, there is currently a lack of effective methods of conservative treatment.
Disclosure of Invention
The invention aims at providing a traditional Chinese medicine raw material composition, a pharmaceutical composition and application thereof.
According to an aspect of the present invention, there is provided a Chinese medicinal raw material composition comprising the following active ingredients by weight: 10-30 parts of selfheal; at least one of 3-30 parts of semen vaccariae, 9-40 parts of caulis spatholobi, 6-30 parts of roasted rhizoma cyperi, 3-20 parts of semen citri reticulatae and 10-30 parts of dandelion; at least one of 2-20 parts of liquorice and 6-20 parts of fructus cnidii; 3-30 parts of eupatorium; and optionally at least one of 3-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia.
According to an exemplary embodiment of the present invention, the Chinese medicine raw material composition may include the following active ingredients by weight: 20-30 parts of selfheal; 10-30 parts of semen vaccariae, 15-40 parts of caulis spatholobi, 15-30 parts of roasted rhizoma cyperi, 15-20 parts of semen citri reticulatae and 20-30 parts of dandelion; 10-20 parts of liquorice and 15-20 parts of fructus cnidii; 10-30 parts of eupatorium; and optionally at least one of 10-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia.
According to an exemplary embodiment of the present invention, the Chinese medicine raw material composition may include the following active ingredients by weight: 20-30 parts of selfheal, 20-30 parts of dandelion, 10-20 parts of liquorice and 10-30 parts of eupatorium.
According to an exemplary embodiment of the present invention, the Chinese medicine raw material composition may include the following active ingredients by weight: 20-30 parts of selfheal, 10-30 parts of semen vaccariae, 15-40 parts of suberect spatholobus stem, 15-20 parts of fructus cnidii and 10-30 parts of herba eupatorii.
According to an exemplary embodiment of the present invention, the Chinese medicine raw material composition may include the following active ingredients by weight: 20-30 parts of selfheal, 10-30 parts of semen vaccariae, 15-40 parts of suberect spatholobus stem, 15-30 parts of roasted nutgrass galingale rhizome, 15-20 parts of tangerine seed, 20-30 parts of dandelion, 10-20 parts of liquorice, 15-20 parts of common cnidium fruit and 10-30 parts of eupatorium.
According to another aspect of the present invention, there is provided a pharmaceutical composition made of the above-described Chinese medicinal raw material composition.
According to an exemplary embodiment of the present invention, the pharmaceutical composition may further comprise pharmaceutically acceptable excipients.
According to an exemplary embodiment of the present invention, the pharmaceutically acceptable auxiliary material may include at least one of starch, maltose, sucrose, honey and vegetable oil.
According to an exemplary embodiment of the present invention, the pharmaceutical composition may be prepared by the steps of: placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in the form of decoction pieces into a decocting container, and adding water into the decocting container; and decocting for a predetermined time, and filtering to remove residues to obtain medicinal composition as decoction.
According to an exemplary embodiment of the present invention, the pharmaceutical composition may be prepared by the steps of: placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in the form of decoction pieces into a decocting container, and adding water into the decocting container; and decocting for a predetermined time, and filtering to obtain residue to obtain the pharmaceutical composition as dressing.
According to an exemplary embodiment of the present invention, the pharmaceutical composition may be prepared by the steps of: drying and pulverizing each traditional Chinese medicine raw material in the form of decoction pieces in the traditional Chinese medicine raw material composition to 80-120 meshes; mixing the crushed Chinese medicinal materials, and aging and sterilizing at 100-110deg.C for 10-30 min to obtain the medicinal composition as powder.
According to an exemplary embodiment of the present invention, the pharmaceutical composition may be prepared by the steps of: placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in a decoction piece form into a decoction container, and adding water into the decoction container; decocting for a predetermined time, and removing residue to obtain decoction; adding pharmaceutically acceptable auxiliary materials into the medicinal soup, and decocting to obtain the medicinal composition as paste.
According to a further aspect of the present invention there is provided the use of a traditional Chinese medicine raw material composition as described above or a pharmaceutical composition as described above in the manufacture of a medicament for the treatment of mastitis, hyperplasia of mammary glands, breast nodules or breast cysts.
The traditional Chinese medicine raw material composition and the pharmaceutical composition have the effects of activating blood circulation, regulating qi, softening and resolving hard mass, dredging collaterals and relieving pain, and also have the functions of softening and resolving hard mass, detumescence and relieving pain, activating blood and dredging collaterals, and have obvious curative effects of treating mastitis, hyperplasia of mammary glands, breast nodules or galactocele and the like. In addition, the traditional Chinese medicine raw material composition and the pharmaceutical composition can fundamentally improve the life quality of patients. In addition, the traditional Chinese medicine raw material composition and the pharmaceutical composition have no obvious toxic or side effect. Furthermore, the pharmaceutical composition of the present invention can be used in combination with the dressing of the present invention to better treat mastitis conditions.
Detailed Description
The raw material composition of the traditional Chinese medicine, the pharmaceutical composition and the application thereof of the present invention will now be described in detail.
Based on years of traditional Chinese medicine experience, the inventor of the invention proposes a traditional Chinese medicine raw material composition and a pharmaceutical composition for treating mastopathy such as mastitis, hyperplasia of mammary glands, breast nodules or galactocele.
The traditional Chinese medicine raw material composition comprises the following active ingredients (or consists of the following active ingredients) by weight: 10-30 parts of selfheal; at least one of 3-30 parts of semen vaccariae, 9-40 parts of caulis spatholobi, 6-30 parts of roasted rhizoma cyperi, 3-20 parts of semen citri reticulatae and 10-30 parts of dandelion; at least one of 2-20 parts of liquorice and 6-20 parts of fructus cnidii; 3-30 parts of eupatorium; and optionally at least one of 3-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia.
Furthermore, in an exemplary embodiment of the present invention, the Chinese medicinal raw material composition according to the present invention may further include pharmaceutically acceptable excipients, for example, at least one of starch, maltose, sucrose, honey and vegetable oil; however, the present invention is not limited thereto. Specifically, the traditional Chinese medicine raw material composition according to the invention can comprise 10-30 parts of selfheal, 3-30 parts of semen vaccariae, 9-40 parts of suberect spatholobus stem, 6-30 parts of roasted nutgrass galingale rhizome, 3-20 parts of tangerine seed and 10-30 parts of dandelion, 2-20 parts of liquorice and 6-20 parts of fructus cnidii, 3-30 parts of eupatorium, and optionally at least one of 3-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia as an effective ingredient and a pharmaceutically acceptable auxiliary material; or the medicine consists of at least one of 10-30 parts of selfheal, 3-30 parts of semen vaccariae, 9-40 parts of suberect spatholobus stem, 6-30 parts of roasted nutgrass galingale rhizome, 3-20 parts of tangerine seed and 10-30 parts of dandelion, 2-20 parts of liquorice and at least one of 6-20 parts of fructus cnidii, 3-30 parts of eupatorium, and optionally at least one of 3-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia serving as an effective component and a pharmaceutically acceptable auxiliary material.
Prunella vulgaris (Latin brand name: PRUNELLAE SPICA) can be dried fruit of Prunella vulgaris Prunella vulgaris L. The amount of the selfheal may be in the range of 10 parts to 30 parts, for example, the amount of the selfheal may be in the range of 12 parts to 28 parts, 14 parts to 26 parts, 16 parts to 24 parts, 18 parts to 22 parts or 20 parts to 30 parts, or any of the ranges defined by the numerical values given above, for example, 12 parts to 26 parts, 14 parts to 28 parts. Prunella vulgaris has effects of clearing liver fire, resolving stagnation, and can be used for treating liver fire conjunctival congestion, swelling and pain, scrofula, tuberculosis, goiter, acute mastitis, etc.
The semen Vaccariae (Latin brand name: VACCARIAE SEMEN) may be dried mature seed of Garcke of Caryophyllaceae plant herba Cynanchi Stauntonii Vaccaria segetalis (Neck.). The amount of the seed of the cowherb is in the range of 3 to 30 parts, for example, the amount of the seed of the cowherb can be in the range of 5 to 25 parts, 10 to 20 parts or 10 to 30 parts, or any of the ranges defined by the numerical values given above, for example, 10 parts to 25 parts. Semen Vaccariae has effects of promoting blood circulation, dredging channels, promoting lactation, and promoting urination, and can be used for treating blood stasis amenorrhea, galactostasis, dystocia, carbuncle, and malignant boil.
Caulis Spatholobi (Latin chemical name: SPATHOLOBI CAULIS) can be dried rattan of Spatholobus stem Spatholobus suberectus Dunn of Leguminosae. The amount of the spatholobus stem is in the range of 9 to 40 parts, for example, the amount of the spatholobus stem may be in the range of 10 to 40 parts, 15 to 35 parts, 20 to 30 parts, or any of the ranges defined by the numerical values given above, for example, 15 to 40 parts or 15 to 30 parts. Caulis Spatholobi has effects of replenishing blood, promoting blood circulation, relieving rigidity of muscles and activating collaterals, and can be used for treating soreness of waist and knee, limb numbness, rheumatism paralysis, dysmenorrhea, etc.
The roasted RHIZOMA Cyperi is prepared by parching RHIZOMA Cyperi with optional adjuvants, and RHIZOMA Cyperi (Latin brand name: cyperi RHIZOMA) can be dried rhizome of Cyperus rotundus L. Belonging to Cyperaceae. The amount of the roasted nutgrass galingale rhizome is in the range of 6 parts to 30 parts, for example, the amount of the roasted nutgrass galingale rhizome may be in the range of 10 parts to 30 parts, 15 parts to 25 parts, or any range defined by the numerical values given above, for example, 15 parts to 30 parts. The prepared nutgrass galingale rhizome can sooth liver, regulate qi, regulate menstruation and relieve pain, and is used for chest, rib, epigastric pain, dysmenorrhea and the like.
The semen Citri Reticulatae (Latin brand name: CITRI RETICULATAE SEMEN) can be dry mature seed of Rutaceae plant orange Citrus reticulata Blanco and its cultivar. The amount of the orange core is in the range of 3 parts to 20 parts, for example, the amount of the orange core may be in the range of 5 parts to 20 parts, 7 parts to 18 parts, or 10 parts to 15 parts, or any of the ranges defined by the numerical values given above, for example, 15 parts to 20 parts. The tangerine seeds can soften hardness and dissipate nodulation, regulate qi and alleviate pain. Can be used for treating pain of multiple parts of human body.
HERBA Taraxaci (Latin, taraxaci HERBA) can be selected from dried whole herb of Taraxacum officinale Taraxacum mongolicum hand-Mazz, taraxacum officinale Taraxacum borealisinense Kitam or several plants of the same genus. The dandelion may be used in an amount ranging from 10 parts to 30 parts, for example, dandelion may be used in an amount ranging from 12 parts to 28 parts, 14 parts to 26 parts, 16 parts to 24 parts, or 20 parts to 30 parts, or any of the ranges defined by the numerical values given above, for example, 16 parts to 30 parts. Dandelion has the actions of clearing heat and removing toxicity, promoting diuresis, resolving hard mass and relieving swelling. Can be used for treating furuncle, toxic heat, acute mastitis, and swelling and pain.
Glycyrrhrizae radix (Latin brand name: GLYCYRRHIZAE RADIX ET RHIZOMA) can be dry root and rhizome of Glycyrrhrizae radix Glycyrrhiza uralensis Fisch. Glycyrrhiza glabra Glycyrrhiza inflata bat. Or Glycyrrhiza glabra Glycyrrhiza glabra L. Of Leguminosae. The amount of licorice is in the range of 2 parts to 20 parts, for example, the amount of licorice may be in the range of 5 parts to 20 parts, 7 parts to 17 parts, or 10 parts to 15 parts, or any of the ranges defined by the numerical values given above, for example, 10 parts to 20 parts. Glycyrrhrizae radix has effects of clearing heat and detoxicating, and harmonizing drug property, and can be used for treating stomach and abdomen spasm pain, laryngopharynx swelling and pain, pyocutaneous disease and toxic swelling etc.
FRUCTUS Cnidii (Latin brand name: CNIDII FRUCTUS) can be dry mature fruit of cnidiumonii (L.) Cuss. The amount of fructus Cnidii is in the range of 6 parts to 20 parts, for example, the amount of fructus Cnidii may be in the range of 5 parts to 20 parts, 7 parts to 17 parts, or 10 parts to 15 parts, or any of the ranges defined by the numerical values given above, for example, 15 parts to 20 parts. Fructus Cnidii has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, and relieving itching, and can be used for treating pudendum eczema pruritus, etc.
HERBA Eupatorii (Latin brand name: eupatorii HERBA) may be dry aerial parts of Eupatorium fortunei Eupatorium fortunei Turcz. The amount of eupatorium is in the range of 3 parts to 30 parts, for example, the amount of eupatorium may be in the range of 5 parts to 30 parts, 10 parts to 25 parts or 15 parts to 20 parts, or any of the ranges defined by the values given above, for example, 10 parts to 30 parts. Herba Eupatorii has effects of eliminating dampness, dispelling pathogenic factors, and can be used for aversion to cold, fever, and distention and oppression of head.
The flos Rosae Rugosae (Latin chemical name: ROSAE RUGOSAE FLOS) can be dried flower bud of Rosa rugosa Thunb. The amount of rose is in the range of 3 parts to 15 parts, for example, the amount of rose may be in the range of 5 parts to 15 parts, 6 parts to 14 parts, 7 parts to 13 parts, 8 parts to 14 parts, 9 parts to 13 parts or 10 parts to 12 parts, or any of the ranges defined by the values given above, for example, 10 parts to 15 parts. The rose can regulate qi, alleviate depression, promote blood circulation, remove blood stasis, regulate menstruation and relieve pain, and can be used for treating breast distending pain, irregular menstruation and the like.
Lavender (Latin brand name: lavandula angustifolia Mill.) may be whole herb of Lavender belonging to Labiatae family. The amount of lavender is in the range of 10 parts to 15 parts, for example, the amount of lavender may be in the range of 11 parts to 14 parts or 12 parts to 13 parts, or any of the ranges defined by the values given above, for example, 11 parts to 13 parts. Lavender has effects of clearing heat and detoxicating, dispelling pathogenic wind and relieving itching.
Camellia is the flower of camellia (Latin brand name: camellia japonica L.). The amount of camellia may be in the range of 10 parts to 15 parts, for example, the amount of camellia may be in the range of 11 parts to 14 parts or 12 parts to 13 parts, or any of the ranges defined by the values given above, for example, 11 parts to 13 parts. The camellia has the effects of astringing, stopping bleeding, cooling blood, regulating stomach, regulating qi, removing blood stasis, relieving swelling and the like.
Gardenia (Latin brand name: gardenia jasminoides Ellis) can be evergreen shrubs of Gardenia genus of Rubiaceae family. The amount of gardenia is in the range of 10 parts to 15 parts, for example, the amount of gardenia may be in the range of 11 parts to 14 parts or 12 parts to 13 parts, or any of the ranges defined by the numerical values given above, for example, 11 parts to 13 parts. The gardenia has the effects of purging pathogenic fire, relieving restlessness, clearing heat, promoting urination, cooling blood and removing toxin.
The inventor of the invention makes a series of breakthrough progress in the aspect of the research of preventing and treating mammary gland diseases by traditional Chinese medicine according to years of experience of traditional Chinese medicine, and innovatively proposes the traditional Chinese medicine raw material composition by taking the effects of warming and removing stasis, activating blood and dredging collaterals as a treatment method.
Specifically, the formula principle of the traditional Chinese medicine raw material composition provided by the invention is as follows: the Chinese medicinal composition has the main treatment effects on mastitis, hyperplasia of mammary glands, breast nodules or galactocele by taking the Chinese medicinal materials with the functions of warming and resolving masses, promoting blood circulation and removing obstruction in collaterals as treatment theories, and the Chinese medicinal materials are indispensable; at least one of semen Vaccariae, caulis Spatholobi, rhizoma Cyperi preparata, semen Citri Reticulatae and herba Taraxaci is used as ministerial drug for assisting monarch drug in enhancing therapeutic effect; at least one of Glycyrrhrizae radix and fructus Cnidii is used as adjuvant to strengthen the effects of softening and resolving hard mass, promoting blood circulation for removing blood stasis, dredging collaterals and relieving pain; the eupatorium is taken as a guiding drug and a harmonizing drug in nature, plays roles of harmonizing, reducing or eliminating adverse reactions after the cooperation of the drugs, and further, has the effects of resisting bacteria, diminishing inflammation, relieving pain and relieving itching in the traditional Chinese medicine raw material composition. In addition, in the present invention, at least one of rose, lavender, camellia and gardenia can formulate the odor of the raw material composition and the pharmaceutical composition of the traditional Chinese medicine according to the present invention to have faintness. Therefore, in the traditional Chinese medicine raw material composition and the pharmaceutical composition, the above medicines are used together, so that obvious synergistic effect is exerted, the efficacy is clear, the quality is controllable, and a new choice is provided for treating the mammary gland diseases. In addition, licorice and cnidium fruit can be used simultaneously to raise anti-sensitization effect.
In conclusion, the traditional Chinese medicine raw material composition and the pharmaceutical composition are accurate in compatibility, and can effectively treat mastopathy such as mastitis, hyperplasia of mammary glands, breast nodules or galactocele. In addition, the traditional Chinese medicine raw material composition and the pharmaceutical composition can effectively improve clinical symptoms of patients and life quality, and have no obvious adverse reaction. In addition, the invention evaluates the effectiveness and safety of the traditional Chinese medicine raw material composition and the pharmaceutical composition from clinical experiments, thereby proving the dominant curative effect of the traditional Chinese medicine raw material composition and the pharmaceutical composition in treating mastopathy such as mastitis, hyperplasia of mammary glands, breast nodules or galactocele and the like, and providing a new method for treating the mastopathy.
Furthermore, in a preferred embodiment of the present invention, the Chinese medicinal raw material composition may include (or consist of) the following active ingredients by weight: 20-30 parts of selfheal; 10-30 parts of semen vaccariae, 15-40 parts of caulis spatholobi, 15-30 parts of roasted rhizoma cyperi, 15-20 parts of semen citri reticulatae and 20-30 parts of dandelion; 10-20 parts of liquorice and 15-20 parts of fructus cnidii; 10-30 parts of eupatorium; and optionally at least one of 10-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia.
In another preferred embodiment of the present invention, the Chinese medicinal raw material composition may include (or consist of) the following active ingredients by weight: 20-30 parts of selfheal, 20-30 parts of dandelion, 10-20 parts of liquorice and 10-30 parts of eupatorium.
In a further preferred embodiment of the present invention, the Chinese medicinal raw material composition may include (or consist of) the following active ingredients by weight: 20-30 parts of selfheal, 10-30 parts of semen vaccariae, 15-40 parts of suberect spatholobus stem, 15-20 parts of fructus cnidii and 10-30 parts of herba eupatorii.
In a further preferred embodiment of the present invention, the Chinese medicinal raw material composition may include (or consist of) the following active ingredients by weight: 20-30 parts of selfheal, 10-30 parts of semen vaccariae, 15-40 parts of suberect spatholobus stem, 15-30 parts of roasted nutgrass galingale rhizome, 15-20 parts of tangerine seed, 20-30 parts of dandelion, 10-20 parts of liquorice, 15-20 parts of common cnidium fruit and 10-30 parts of eupatorium.
Furthermore, in the embodiment of the present invention, the above-mentioned raw materials of Chinese medicine may be used in the form of decoction pieces which reach quality standards after preliminary processing or concoction treatment. The above mentioned raw materials of traditional Chinese medicine may be used in the form of traditional Chinese medicine. The above-mentioned raw materials of Chinese medicine may be used in the form of Chinese medicinal materials and decoction pieces.
The pharmaceutical composition according to the invention is prepared from the above traditional Chinese medicine raw material composition.
The pharmaceutical composition of the invention can be prepared by adopting a conventional preparation method of traditional Chinese medicines.
In one embodiment of the present invention, the pharmaceutical composition as a decoction may be prepared by the steps of: placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in the form of decoction pieces into a decocting container, and adding water into the decocting container; and decocting for a predetermined time, and filtering to remove residues to obtain medicinal composition as decoction. Specifically, each of the Chinese medicinal materials in the form of decoction pieces is put into a decocting vessel, water is added into the decocting vessel, after boiling with strong fire, the decoction is decocted with small fire for 30 minutes, and the decoction is decocted for two to three times (for example, twice), and each time the decoction is decocted to 200 milliliters, and the decoction is filtered to obtain the medicinal composition serving as decoction.
In another embodiment of the invention, the pharmaceutical composition as an application is made by the steps of: placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in the form of decoction pieces into a decocting container, and adding water into the decocting container; and decocting for a predetermined time, and filtering to obtain residue to obtain the pharmaceutical composition as dressing. Specifically, each of the Chinese medicinal materials in the form of decoction pieces is put into a decocting vessel, water is added into the decocting vessel, after boiling with strong fire, decocting with slow fire for 30 minutes, and the residue is obtained by filtration, so as to obtain the pharmaceutical composition as an application.
In yet another embodiment of the present invention, a pharmaceutical composition as a powder is made by the steps of: drying and pulverizing each Chinese medicinal material in decoction piece form in the Chinese medicinal material composition to 80-120 mesh; mixing the crushed Chinese medicinal materials, and aging and sterilizing at 100-110deg.C for 10-30 min to obtain medicinal composition as powder.
In yet another embodiment of the present invention, the pharmaceutical composition as a paste is prepared by the steps of: placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in the form of decoction pieces into a decocting container, and adding water into the decocting container; decocting for a predetermined time, and removing residue to obtain decoction; adding pharmaceutically acceptable adjuvants (such as starch, vegetable oil, etc.) into the decoction, and decocting to obtain medicinal composition as paste.
The pharmaceutical composition provided by the invention has the effects of promoting blood circulation, regulating qi, softening hardness, dissipating stagnation, dredging collaterals and relieving pain. In addition, the pharmaceutical composition provided by the invention has no obvious toxic or side effect, can effectively improve clinical symptoms of patients and life quality, and has no obvious adverse reaction.
According to another aspect of the invention there is provided the use of a traditional Chinese medicine raw material composition as described above or a pharmaceutical composition as described above in the manufacture of a medicament for the treatment of mastitis, hyperplasia of mammary glands, breast nodules or breast cysts.
In addition, the traditional Chinese medicine raw material composition and the pharmaceutical composition according to the embodiment of the invention have remarkable effects in treating breast diseases.
The pharmaceutical compositions and methods of preparation of the present invention will be described in the following specific examples.
Example 1: decoction and dressing
Traditional Chinese medicine raw materials: 20 g of selfheal, 25 g of dandelion, 10 g of eupatorium and 10 g of liquorice.
The preparation method comprises the following steps: adding the above Chinese medicinal materials into a decocting container, adding water until the above Chinese medicinal materials are not used, decocting with strong fire for 30min, decocting twice with slow fire to 200 ml each time, and filtering to obtain decoction and residue (i.e. dressing).
Example 2: decoction
Traditional Chinese medicine raw materials: 20 g of selfheal, 20 g of semen vaccariae, 20 g of suberect spatholobus stem, 10 g of eupatorium and 15 g of fructus cnidii.
The preparation method comprises the following steps: a decoction was prepared according to the preparation method of example 1.
Example 3: decoction
Traditional Chinese medicine raw materials: 25 g of selfheal, 15 g of semen vaccariae, 15 g of semen citri reticulatae, 25 g of dandelion, 15 g of roasted nutgrass galingale rhizome, 30 g of suberect spatholobus stem, 10 g of eupatorium, 10 g of liquorice and 20 g of fructus cnidii.
The preparation method comprises the following steps: a decoction was prepared according to the preparation method of example 1.
Example 4: decoction and dressing
Traditional Chinese medicine raw materials: 30 g of selfheal, 20 g of semen vaccariae, 20 g of semen citri reticulatae, 30 g of dandelion, 20 g of roasted nutgrass galingale rhizome, 25 g of suberect spatholobus stem, 10 g of eupatorium, 10 g of liquorice and 15 g of fructus cnidii.
The preparation method comprises the following steps: decoction and dressing were prepared according to the preparation method of example 1.
Example 5: powder preparation
Traditional Chinese medicine raw materials: 30 g of selfheal, 20 g of semen vaccariae, 20 g of semen citri reticulatae, 30 g of dandelion, 30 g of roasted nutgrass galingale rhizome, 30 g of suberect spatholobus stem, 30 g of eupatorium, 20 g of liquorice and 20 g of fructus cnidii.
The preparation method comprises the following steps: drying and pulverizing the above Chinese medicinal materials to 100 mesh, mixing the pulverized Chinese medicinal materials, and aging and sterilizing at 100deg.C for 20 min to obtain powder.
Example 6: powder preparation
Traditional Chinese medicine raw materials: 25 g of selfheal, 30 g of semen vaccariae, 15 g of semen citri reticulatae, 25 g of dandelion, 25 g of roasted nutgrass galingale rhizome, 40 g of suberect spatholobus stem, 25 g of eupatorium, 15 g of liquorice and 15 g of fructus cnidii.
The preparation method comprises the following steps: a powder was prepared according to the procedure of example 5.
Example 7: powder preparation
Traditional Chinese medicine raw materials: 20 g of selfheal, 20 g of semen vaccariae, 20 g of semen citri reticulatae, 20 g of dandelion, 20 g of roasted nutgrass galingale rhizome, 30 g of suberect spatholobus stem, 20 g of eupatorium, 20 g of liquorice and 20 g of fructus cnidii.
The preparation method comprises the following steps: a powder was prepared according to the procedure of example 5.
Example 8: paste
Traditional Chinese medicine raw materials: 25 g of selfheal, 20 g of semen vaccariae, 15 g of semen citri reticulatae, 30 g of dandelion, 15 g of roasted nutgrass galingale rhizome, 30 g of suberect spatholobus stem, 15 g of eupatorium, 15 g of liquorice and 15 g of fructus cnidii.
The preparation method comprises the following steps: placing the above Chinese medicinal materials into a decocting container, adding water into the container, soaking in water until water completely permeates the Chinese medicinal materials, decocting with water for 2 times, filtering to obtain decoction, adding starch and vegetable oil into the decoction, and decocting to obtain paste.
Example 9: paste
Traditional Chinese medicine raw materials: 30 g of selfheal, 30 g of semen vaccariae, 20 g of semen citri reticulatae, 30 g of dandelion, 20 g of roasted nutgrass galingale rhizome, 30 g of suberect spatholobus stem, 20 g of eupatorium, 20 g of liquorice and 20 g of fructus cnidii.
The preparation method comprises the following steps: the paste was prepared according to the preparation method of example 8.
Clinical efficacy observation of the pharmaceutical composition of the invention
Case selection: the total number of patients is 35, and the patients are all patients with hyperplasia of mammary glands, breast nodules, galactocele, mastitis and the like.
The medicine requirement is as follows: the intake of high fat foods is reduced during the treatment.
Notice that: it should be used with cautions for patients with allergy and skin ulcer.
The administration method of each dosage form comprises the following steps:
decoction: the decoction is adjusted to about 40 deg.C, and is applied to the affected part with sterile gauze or sterile cotton pad. The time of each day is not limited, and 30 minutes is suitable for each time. The decoction can be repeatedly heated and applied for one day.
The dressing comprises the following steps: the application agent with the temperature of about 40 ℃ is directly contacted with the affected part of the patient for hot compress. Each time for 30 minutes, 2-6 times daily. The external application range of the dressing is larger than the range of the affected part, and the thickness is better to cover the affected part.
Powder: after the affected part is disinfected, the powder is applied to the affected part and covered with sterile gauze for 2 times a day.
Paste: after the affected part is disinfected, the ointment is uniformly coated on the affected part and covered with sterile gauze for 2 times daily.
The results show that:
patients were treated with the decoction and dressing of examples 1 and 4 and the pharmaceutical compositions of examples 2, 3 and 5 to 9, and 10 patients with symptoms of 7 days of treatment, blood vessel obstruction, breast distention and pain were relieved; a patient 10 with reduced hyperplasia of mammary glands; 15 patients with reduced benign cysts of the breast. After 45 days of treatment, the patients with breast distending pain, hyperplasia of mammary glands and benign cyst of the breast are all improved obviously. Furthermore, no significant adverse reactions were observed throughout the treatment period.
In addition, other patients using examples 1 to 9 were also followed, as follows. Hereinafter, the administration was performed for 1 course of treatment for 7 days.
Clinical trial Using example 1
The traditional Chinese medicine composition prepared in the embodiment 1 is used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: the patient adjusts the temperature of the decoction of the example 1 to about 40 ℃, dips the decoction with sterile gauze or sterile cotton pad, applies the decoction to the affected part of the breast for 30 minutes each time, and the frequency of each day is not limited; the application of example 1 was adjusted to about 40 degrees and was applied directly to the affected area of the patient's breast. Each time for 30 minutes, 2-6 times daily. The external application range of the dressing is larger than the affected area, and the thickness is better to cover the affected area of the breast.
Case 1: the breast distending pain was cured after 1 course of treatment by continuously using the traditional Chinese medicine composition decoction prepared in example 1 and the dressing in combination at 25 years old.
Case 2: the breast distending pain was cured after 1 course of treatment by the combination of the decoction and the dressing of the traditional Chinese medicine composition prepared in example 1 for 1 month after 27 years.
Case 3: the traditional Chinese medicine composition decoction prepared in the example 1 is used for treating 26 years old, hyperplasia of mammary glands and nodules continuously, and is used for curing after 3 treatment courses by combined treatment of the traditional Chinese medicine composition decoction and the dressing.
Case 4: the breast benign cyst of 35 years old was healed after 3 courses of treatment with the combination of the traditional Chinese medicine composition decoction and the dressing prepared in example 1.
Case 5: the breast benign cyst of 37 years old was healed after 3 treatment courses of continuous use of the traditional Chinese medicine composition decoction and the dressing prepared in example 1.
Clinical trials Using example 2
The traditional Chinese medicine composition decoction prepared in the embodiment 2 is used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: the patient adjusts the temperature of the decoction of the traditional Chinese medicine composition of the embodiment 2 to about 40 ℃, dips the decoction with sterile gauze or sterile cotton pad, and applies the decoction to the affected part of the breast. The time of each day is not limited, and 30 minutes is suitable for each time.
Case 6: the breast distending pain was half a month at 26 years old, and the breast distending pain was cured after 1 course of treatment by continuously using the Chinese medicinal composition decoction prepared in example 2.
Case 7: the breast hyperplasia and the breast nodule are cured after 2 half courses of treatment by continuously using the traditional Chinese medicine composition decoction prepared in the example 2.
Case 8:39 years old, benign cysts of the breast healed after 2 half courses of treatment using the traditional Chinese medicine composition decoction prepared in example 2 continuously.
Case 9: the breast benign cyst aged 40 years was healed after 3 courses of treatment with the traditional Chinese medicine composition decoction prepared in example 2.
Clinical trial Using example 3
The traditional Chinese medicine composition decoction prepared in the embodiment 3 is used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: the patient adjusts the temperature of the decoction of the traditional Chinese medicine composition of the embodiment 3 to about 40 ℃, dips the decoction with sterile gauze or sterile cotton pad, and applies the decoction to the affected part of the breast. The time of each day is not limited, and 30 minutes is suitable for each time.
Case 10: the breast distending pain was cured after 1 half course of treatment with the decoction of the traditional Chinese medicine composition prepared in example 3 for 1 month after the age of 29 years.
Case 11:30 years old, hyperplasia of mammary glands and nodules are cured after 3 treatment courses continuously using the traditional Chinese medicine composition decoction prepared in the embodiment 3.
Case 12:32 years old, benign cysts of the breast are healed after 3 courses of treatment using the traditional Chinese medicine composition decoction prepared in example 3 continuously.
Case 13: the breast benign cyst was healed after 35 years old after 3 courses of treatment with the traditional Chinese medicine composition decoction prepared in example 3.
Clinical trials Using example 4
The Chinese medicinal decoction (dressing) prepared in example 4 was used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and breast cyst. The using method comprises the following steps: the patient adjusts the temperature of the traditional Chinese medicine composition decoction of the embodiment 4 to about 40 ℃, dips the decoction with sterile gauze or sterile cotton pad, applies the decoction to the affected part of the breast for 30 minutes each time, and the daily frequency is not limited; the application agent with the temperature of about 40 ℃ is directly contacted with the affected part of the breast of a patient for hot compress. Each time for 30 minutes, 2-6 times daily. The external application range of the dressing is larger than the affected area, and the thickness is better to cover the affected area of the breast.
Case 14: the decoction and the dressing of the traditional Chinese medicine composition prepared in example 4, which are used continuously for treating breast distending pain for 1 month, are cured after 1 treatment course.
Case 15: the decoction and the dressing of the traditional Chinese medicine composition prepared in the example 4 are continuously used for treating 29 years old, hyperplasia of mammary glands and nodules after 2 half courses of treatment.
Case 16: the decoction and the dressing of the traditional Chinese medicine composition prepared in the example 4 are continuously used for treating 31 years old, hyperplasia of mammary glands and nodules after 2 treatment courses.
Case 17: the decoction and the dressing of the traditional Chinese medicine composition prepared in the example 4 are used for treating 2 half courses of treatment after being used for treating 32 years old breast benign cysts continuously.
Case 18: the decoction and the dressing of the traditional Chinese medicine composition prepared in the example 4 are continuously used for treating the benign cyst of the breast after 3 treatment courses after being combined for treatment of 37 years old.
Clinical trial Using example 5
The powder of the traditional Chinese medicine composition prepared in the embodiment 5 is used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: after the patient disinfected the affected area of the breast, the powder of example 5 was applied to the affected area, covered with sterile gauze 2 times daily.
Case 19: the breast distending pain was cured after 1 month at 32 years of age by continuously using the traditional Chinese medicine composition powder prepared in example 5 for 1 course of treatment.
Case 20: the breast hyperplasia and the breast nodule are cured after 3 treatment courses by continuously using the traditional Chinese medicine composition powder prepared in the example 5.
Case 21: after 33 years old, benign cysts of the breast were healed after 3 consecutive courses of treatment using the traditional Chinese medicine composition powder prepared in example 5.
Clinical trial Using example 6
The traditional Chinese medicine composition powder prepared in the example 6 is used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: after the patient disinfected the affected area of the breast, the powder of example 6 was applied to the affected area, covered with sterile gauze 2 times daily.
Case 22: after 27 years old, breast distending pain was cured for 2 months after 1 course of treatment with the traditional Chinese medicine composition powder prepared in example 6 continuously.
Case 23:30 years old, hyperplasia of mammary glands and nodules, and the traditional Chinese medicine composition powder prepared in the example 6 is continuously used for curing after 2 half courses of treatment.
Case 24: after 35 years old, benign cysts of the breast were healed after 2 half courses of treatment with the traditional Chinese medicine composition powder prepared in example 6 continuously.
Clinical trial Using example 7
The powder of the Chinese medicinal composition prepared in the example 7 is used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: after the patient disinfected the affected area of the breast, the powder of example 7 was applied to the affected area, covered with sterile gauze 2 times daily.
Case 25: after 30 years old, breast distending pain was cured for 2 months after 1 course of treatment with the traditional Chinese medicine composition powder prepared in example 7 continuously.
Case 26: the breast hyperplasia and the breast nodule are cured after 3 half courses of treatment by continuously using the traditional Chinese medicine composition powder prepared in the example 7.
Case 27: after 37 years old, benign cysts of the breast are cured after 3 half courses of treatment with the traditional Chinese medicine composition powder prepared in example 7.
Clinical trial Using example 8
The Chinese medicinal composition paste prepared in example 8 is used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: after the patient disinfected the affected area of the breast, the ointment of example 8 was applied to the affected area evenly, covered with sterile gauze 2 times daily.
Case 28: the breast distending pain was cured after 1 course of treatment with the paste of the Chinese medicinal composition prepared in example 8 for 1 month after the age of 27 years.
Case 29:30 years old, hyperplasia of mammary glands and nodules, and the traditional Chinese medicine composition ointment prepared in the example 8 is continuously used for curing after 2 treatment courses.
Case 30: the breast benign cyst was cured after 2 half courses of treatment with the traditional Chinese medicine composition paste prepared in example 8 continuously at 31 years old.
Case 31:39 years old, benign cysts of the breast healed after 3 half courses of treatment with the paste of the traditional Chinese medicine composition prepared in example 8.
Clinical trial Using example 9
The Chinese medicinal composition paste prepared in example 9 was used for treating patients with mastitis, hyperplasia of mammary glands, breast nodules and galactocele. The using method comprises the following steps: after the patient disinfected the affected area of the breast, the ointment of example 9 was applied to the affected area uniformly, covered with sterile gauze 2 times daily.
Case 32: the breast distending pain was cured after 1 course of treatment with the paste of the Chinese medicinal composition prepared in example 9 continuously for 1 month at 25 years old.
Case 33: the breast hyperplasia and the breast nodule after 27 years old are cured after 2 treatment courses continuously using the traditional Chinese medicine composition paste prepared in the example 9.
Case 34: after 33 years old, benign cysts of the breast were healed after 2 half courses of treatment using the traditional Chinese medicine composition paste prepared in example 9 continuously.
Case 35: the breast benign cyst was cured after 3 consecutive courses of treatment with the paste of the traditional Chinese medicine composition prepared in example 9 at age 35.
In conclusion, in the traditional Chinese medicine raw material composition and the pharmaceutical composition, the above medicines are used together, so that obvious synergistic effect is exerted, the efficacy is clear, and the quality is controllable. In addition, the use of the pharmaceutical composition of the present invention can reduce and alleviate the development and exacerbation of the above diseases. In addition, the pharmaceutical composition can achieve the effects of softening hardness, resolving hard mass, activating blood, dissolving stasis, dredging collaterals and relieving pain.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments. Within the scope of the technical idea of the invention, various modifications and combinations of the technical solutions of the invention can be made, which modifications and combinations all belong to the protection scope of the invention.
Claims (11)
1. The traditional Chinese medicine raw material composition is characterized by comprising the following active ingredients in parts by weight:
10-30 parts of selfheal;
at least one of 3-30 parts of semen vaccariae, 9-40 parts of caulis spatholobi, 6-30 parts of roasted rhizoma cyperi, 3-20 parts of semen citri reticulatae and 10-30 parts of dandelion;
at least one of 2-20 parts of liquorice and 6-20 parts of fructus cnidii;
3-30 parts of eupatorium; and
optionally, at least one of 3-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia.
2. The traditional Chinese medicine raw material composition according to claim 1, wherein the traditional Chinese medicine raw material composition comprises the following active ingredients by weight:
20-30 parts of selfheal;
10-30 parts of semen vaccariae, 15-40 parts of caulis spatholobi, 15-30 parts of roasted rhizoma cyperi, 15-20 parts of semen citri reticulatae and 20-30 parts of dandelion;
10-20 parts of liquorice and 15-20 parts of fructus cnidii;
10-30 parts of eupatorium; and
optionally, at least one of 10-15 parts of rose, 10-15 parts of lavender, 10-15 parts of camellia and 10-15 parts of gardenia.
3. The traditional Chinese medicine raw material composition according to claim 1, wherein the traditional Chinese medicine raw material composition comprises the following active ingredients by weight: 20-30 parts of selfheal, 20-30 parts of dandelion, 10-20 parts of liquorice and 10-30 parts of eupatorium.
4. The traditional Chinese medicine raw material composition according to claim 1, wherein the traditional Chinese medicine raw material composition comprises the following active ingredients by weight: 20-30 parts of selfheal, 10-30 parts of semen vaccariae, 15-40 parts of suberect spatholobus stem, 15-20 parts of fructus cnidii and 10-30 parts of herba eupatorii.
5. The traditional Chinese medicine raw material composition according to claim 1, wherein the traditional Chinese medicine raw material composition comprises the following active ingredients by weight: 20-30 parts of selfheal, 10-30 parts of semen vaccariae, 15-40 parts of suberect spatholobus stem, 15-30 parts of roasted nutgrass galingale rhizome, 15-20 parts of tangerine seed, 20-30 parts of dandelion, 10-20 parts of liquorice, 15-20 parts of common cnidium fruit and 10-30 parts of eupatorium.
6. A pharmaceutical composition, characterized in that it is made of the traditional Chinese medicine raw material composition according to any one of claims 1 to 5.
7. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition is prepared by the steps of:
placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in a decoction piece form into a decoction container, and adding water into the decoction container; and
after decocting for a predetermined time, filtering to remove residues, and obtaining the pharmaceutical composition as decoction.
8. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition is prepared by the steps of:
placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in a decoction piece form into a decoction container, and adding water into the decoction container; and
after decocting for a predetermined time, the residue is obtained by filtration to obtain the pharmaceutical composition as a dressing.
9. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition is prepared by the steps of:
drying and pulverizing each traditional Chinese medicine raw material in the form of decoction pieces in the traditional Chinese medicine raw material composition to 80-120 meshes;
mixing the crushed Chinese medicinal materials, and aging and sterilizing at 100-110deg.C for 10-30 min to obtain the medicinal composition as powder.
10. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition is prepared by the steps of:
placing each traditional Chinese medicine raw material in the traditional Chinese medicine raw material composition in a decoction piece form into a decoction container, and adding water into the decoction container;
decocting for a predetermined time, and removing residue to obtain decoction;
adding pharmaceutically acceptable auxiliary materials into the medicinal soup, and decocting to obtain the medicinal composition as paste.
11. Use of a traditional Chinese medicine raw material composition according to any one of claims 1 to 5 or a pharmaceutical composition according to any one of claims 6 to 10 for the preparation of a medicament for the treatment of mastitis, hyperplasia of mammary glands, breast nodules or breast cysts.
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| CN108245635A (en) * | 2018-04-16 | 2018-07-06 | 陕西博臻医药科技有限公司 | A kind of external used medicine for treating cyclomastopathy and mastodynia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108245635A (en) * | 2018-04-16 | 2018-07-06 | 陕西博臻医药科技有限公司 | A kind of external used medicine for treating cyclomastopathy and mastodynia |
Non-Patent Citations (1)
| Title |
|---|
| 曾荃: "急性乳腺炎", 广西中医药, no. 01, 20 February 1981 (1981-02-20), pages 35 * |
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