CN105535389A - Traditional Chinese medicinal composition for treating lumbar and cervical bone hyperplasia and preparation method thereof - Google Patents

Traditional Chinese medicinal composition for treating lumbar and cervical bone hyperplasia and preparation method thereof Download PDF

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Publication number
CN105535389A
CN105535389A CN201610033115.XA CN201610033115A CN105535389A CN 105535389 A CN105535389 A CN 105535389A CN 201610033115 A CN201610033115 A CN 201610033115A CN 105535389 A CN105535389 A CN 105535389A
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cervical vertebra
chinese medicine
medicine composition
radix
active component
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何东良
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Guangxi Fuxinyi Biological Technology Co Ltd
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Guangxi Fuxinyi Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125Camphor; Nuclear substituted derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/24Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention relates to a traditional Chinese medicinal composition for treating lumbar and cervical bone hyperplasia and a preparation method thereof. The traditional Chinese medicinal composition comprises the following raw materials: galium aparine, euphorbiaceae, diversecolor cinquefoil, chengkou mahonia, azedarach, monkshood, radix aconiti kusnezoffii, fistular onion stalk, ardisia punctata, alangium platanifolium, periploca forrestii schltr, parabarium huaitingii, faamh gov buerng, camphor and alcohol. The invention further provides the preparation method for the traditional Chinese medicinal composition. The traditional Chinese medicinal composition provided by the invention has the effects of dispelling wind, eliminating dampness, warming and activating meridian, activating blood and relieving pain, and has a remarkable effect on treating lumbar and cervical bone hyperplasia.

Description

A kind ofly treat Chinese medicine composition of waist hyperosteogeny of cervical vertebra and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind ofly treat Chinese medicine composition of waist hyperosteogeny of cervical vertebra and preparation method thereof.
Background technology
Hyperosteogeny causes joint, local, muscle, ligament moving obstacle with sclerotin pathological proliferation, and the pain that occurs together is the disease of cardinal symptom.The places such as cervical vertebra, lumbar vertebra, joint and calcaneus can be occurred in, comprise hypertrophy spondylitis, hpertrophic osteoarthropathy and calcanean spur etc.Primary disease is apt to occur in the person in middle and old age of more than 40 years old and is engaged in the staff of load-bearing, for a long time station, sitting, common with the pathological changes of the larger joint of range of activity, vertebra.The cause of disease of bone matrix hyperplasia is not bright so far, belongs to the category of senile degeneration more, a lot of about its etiology and pathogenesis hypothesis, as machinery say, function is said, angiopathy, dysbolism, dyshormonia etc.Basic understandings is on interior gene basis, is caused morbidity by bringing out of exopathogenic factor.Current doctor trained in Western medicine adopts non-hormone antiinflammation pain-stopping pharmaceutical, physical therapy and operative treatment, has certain effect, but there is no special effective therapy so far to relief of symptoms.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra;
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of waist hyperosteogeny of cervical vertebra.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra of the present invention is prepared from by the raw material comprising following weight portion:
Radix Aconiti 20-60 part, Radix Aconiti Kusnezoffii 20-60 part, Bulbus Allii Fistulosi 5-20 part, blood party 10-30 part, Radix Alangii 10-30 part, Heiguteng exract 10-30 part, red nine Ns of 10-30 parts, Radix Parthenocissi Heterophyllae 10-30 part, Camphora 1-3 part, ethanol 5-15 part.
Preferably, be prepared from by the raw material comprising following weight portion:
Radix Aconiti 30-50 part, Radix Aconiti Kusnezoffii 30-50 part, Bulbus Allii Fistulosi 10-15 part, blood party 15-25 part, Radix Alangii 15-25 part, Heiguteng exract 15-25 part, red nine Ns of 15-25 parts, Radix Parthenocissi Heterophyllae 15-25 part, Camphora 1-2 part, ethanol 5-10 part.
Below the crude drug source of Chinese medicine preparation of the present invention:
Radix Aconiti is the dry parent root of ranunculaceae plant Aconitum carmichjaelii Debx. AconitumcarmichaeliDebx..Pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Radix Aconiti Kusnezoffii is the dried root of ranunculaceae plant Aconitum kusnezoffii Reichb AconitumkusnezoffiiReichb..Pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Bulbus Allii Fistulosi is Liliaceae allium Herba Alii fistulosi AlliumfistulosumL., with bulb or all herbal medicine.Pungent, temperature.Relieving the exterior syndrome by diaphoresis, activates yang, diuresis.For headache due to common cold, nasal obstruction; Dysuria is controlled in external, carbuncle furuncle and phyma poison.
Blood party is root or the Herb of Myrsinacea plant mountain XUEDAN.Bitter; Pungent; Property is put down.Wind-damp dispelling; Promoting blood flow to regulate menstruation; Reducing swelling and alleviating pain.Main air pain of dampness syndrome; Dysmenorrhea; Amenorrhea; Traumatic injury; Laryngopharynx swelling and pain; Nameless gall.
Radix Alangii is Alangiaceae Alangium plant alangium chinense Alangiumchinense(Lour.) Rehd. and melon wood A.platanifolium(Sieb.etZucc.) Harms. with side root, must shape root (fibrous root) and leaf, flower be used as medicine.Pungent, tepor.Poisonous.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, scattered silt pain relieving.Lead to for Fengshi Guanjie, traumatic injury, schizophrenia.
Heiguteng exract (PeriplocaforrestiiSchltr) belongs to dry root or the Herb of Asclepiadaceae (Asclepiadaceae) P. sepium Bunge subfamily (Subfam.Periplocoideaek.Schum) plant Caulis et Radix Periplocae Forrestii; there is the function of expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, the numbness that disappears pain relieving, can relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness; Cure mainly rheumatic arthritis, traumatic injury, stomachache, dyspepsia, amenorrhea, dysentery etc.
Red nine Ns, root, the rattan of apocynaceae plant parabarium huaitingii Chun et Tsiang ParabariumhuaitingiiChunetTsiang.Bitter in the mouth, micro-pungent, property is put down.Slightly poisonous.Dispelling, collateral-activating, bone and muscle strengthening.
Radix Parthenocissi Heterophyllae is root or the stem of vitaceae great Ye parthenocissus.Hardship, temperature.Expelling wind and removing dampness, dredging collateral, hemostasis, removing toxic substances.Dispelling the wind and dampness pathogens arthralgia pain, migraine, rheumatism sore, fracture.
Camphora is Lauraceae cinnamon Camphor tree Cinnamomumcamphora(L.) Presl., with root, branch, leaf and waste wood through distilling the crystalline particulate of gained.Pungent, temperature.Sensible ward off dirty, warming middle-JIAO to relieve pain, dampness removing parasite killing.Vomit and diarrhoea for cold-damp, stomach abdomen pain; Scabies is controlled in external, tinea, dental caries are had a pain.
Wine is a kind of beverage that rice, wheat, broomcorn millet, Sorghum vulgare Pers. etc. and song lead to.Sweetness and bitterness is pungent, temperature.Enter the heart, liver, lung, stomach warp.Promoting blood circulation, resisting cold gas, row medicine gesture.Control wind and cold arthralgia pain, muscle arteries and veins contraction is anxious, the thoracic obstruction, trusted subordinate's cold type of pain.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.Concrete preparation method is as follows:
Scheme one: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme two: get whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme three: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra of the present invention, with pharmaceutically acceptable carrier combination, can make various conventional external preparation, as liniment, granule, lotion, tincture, oil preparation, paste, (soft) unguentum, presses agent etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: distilled water, ethanol etc.
Cosolvent: the polyhydric alcohol such as glycerol, sorbitol.
Antiseptic: benzoic acid, sodium benzoate, propanoic acid, parabens, ethylparaben etc.
Greasing base: vaseline, liquid Paraffin, lanoline, Cera Flava, animal oil, vegetable oil, glyceryl monostearate, octadecanol etc. and composition thereof,
Water-soluble base: glycerol, sodium alginate, carbopol resin, starch gelatin, methylcellulose, sodium carboxymethyl cellulose, Polyethylene Glycol, polyvinyl alcohol.
Penetration enhancer: cutin moisturizing diuretin, pyrrolones derivant, linoleic acid, lauryl alcohol, tween, Dodecyl trimethyl ammonium chloride, dodecyl sodium sulfate, sodium lauryl sulphate, menthol, laurocapram (azone) etc.
Such as, it can be prepared as various common exterior-applied formulation by one of following method:
Method 1: emplastrum
Get one of scheme one to scheme three gained active component, the substrate conventional with emplastrum and base material are made.
Above-mentioned emplastrum acceptable substrate comprises one of cotton, non-woven fabrics, paper, plastic sheeting, aluminium foil, polyethylene composite film, hard gauze; Conventional substrate comprises one of greasing base, water-soluble base, antiseptic, penetration enhancer or whole.
Method 2: liniment
Get one of scheme one to scheme three gained active component, add liniment and commonly use adjuvant, production method is prepared into liniment of the present invention routinely.
Above-mentioned liniment is commonly used adjuvant and is comprised one of diluent, antiseptic, cosolvent, penetration enhancer or whole.
Method 3: unguentum
Get one of scheme one to scheme three gained active component, add unguentum and commonly use adjuvant, production method is prepared into unguentum of the present invention routinely.
Above-mentioned unguentum is commonly used accessory package and is drawn together one of greasing base, water-soluble base, antiseptic, penetration enhancer or whole.
Method 4: lotion
Get one of scheme one to scheme three gained active component, after dilution, add water and stir evenly, leave standstill after filtering, to obtain final product.
The applicant is reference modern pharmacological research achievement on the basis of research tradition tcm syndrome differentiation and treatment, and strong medical treatment experience for many years, through test for many years, multiple formulations is screened, have found a kind of Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra.Formula of the present invention is rationally innovated, Radix Aconiti, Radix Aconiti Kusnezoffii expelling wind and removing dampness, antalgic, is monarch drug in side; Blood party, Radix Alangii, Heiguteng exract, red nine Ns, Radix Parthenocissi Heterophyllae dispels the wind, dehumidifying, invigorates blood circulation, dredging collateral, is ministerial drug in side altogether; Bulbus Allii Fistulosi relieving the exterior syndrome by diaphoresis is adjuvant drug in side; Be equipped with Camphora understand things pain-stopping, ethanol promoting blood circulation, resisting cold gas, row medicine gesture, and the two promotes other drug Transdermal absorption.Full side plays the merit of expelling wind and removing dampness, promoting the flow of QI in the collateral by warming the meridian, promoting blood circulation and stopping pain altogether, and treatment lumbar vertebra, hyperosteogeny of cervical vertebra are evident in efficacy.
A kind of Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra provided by the invention has the following advantages:
1, compositions provided by the invention is safe and effective, the merit of expelling wind and removing dampness, promoting the flow of QI in the collateral by warming the meridian, promoting blood circulation and stopping pain, and treatment lumbar vertebra, hyperosteogeny of cervical vertebra are evident in efficacy.2, compositions provided by the invention has significant curative effect to waist hyperosteogeny of cervical vertebra, and total effective rate reaches 96.0%.
3, Traditional Chinese medicine composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 liniment
Take Radix Aconiti 2kg, Radix Aconiti Kusnezoffii 2kg, Bulbus Allii Fistulosi 0.5kg, blood party 1kg, Radix Alangii 1kg, Heiguteng exract 1kg, red nine Ns of 1kg, Radix Parthenocissi Heterophyllae 1kg, Camphora 0.1kg, ethanol 0.5kg.Extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, and the percent by volume adding clear paste weight 2 times is the ethanol of 95%, stirs evenly, leave standstill 48 hours, filter, add 2 times that purified water ad pond om is medical material gross weight, add the sodium benzoate of 0.1%, the methyl hydroxybenzoate of 0.05%, mixing, subpackage, obtains liniment of the present invention.
Embodiment 2 emplastrum
Take Radix Aconiti 6kg, Radix Aconiti Kusnezoffii 6kg, Bulbus Allii Fistulosi 2kg, blood party 3kg, Radix Alangii 3kg, Heiguteng exract 3kg, red nine Ns of 3kg, Radix Parthenocissi Heterophyllae 3kg, Camphora 0.3kg, ethanol 1.5kg.With 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, coats obtained emplastrum on non-woven fabrics.
Embodiment 3 emplastrum
Take Radix Aconiti 3kg, Radix Aconiti Kusnezoffii 3kg, Bulbus Allii Fistulosi 1kg, blood party 1.5kg, Radix Alangii 1.5kg, Heiguteng exract 1.5kg, red nine Ns of 1.5kg, Radix Parthenocissi Heterophyllae 1.5kg, Camphora 0.1kg, ethanol 0.5kg.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, mix with rubber mass, coat obtained emplastrum on hard gauze.
Embodiment 4 liniment
Take Radix Aconiti 5kg, Radix Aconiti Kusnezoffii 5kg, Bulbus Allii Fistulosi 1.5kg, blood party 2.5kg, Radix Alangii 2.5kg, Heiguteng exract 2.5kg, red nine Ns of 2.5kg, Radix Parthenocissi Heterophyllae 2.5kg, Camphora 0.2kg, ethanol 1kg.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, and each ethanol consumption is respectively 10 times, 8 times of medical material total amount, and extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds 2 times that purified water ad pond om is medical material gross weight, add the sodium benzoate of 0.1%, the methyl hydroxybenzoate of 0.05%, mixing, subpackage, obtains liniment of the present invention.
Embodiment 5 unguentum
Take Radix Aconiti 4kg, Radix Aconiti Kusnezoffii 4kg, Bulbus Allii Fistulosi 1kg, blood party 2kg, Radix Alangii 2kg, Heiguteng exract 2kg, red nine Ns of 2kg, Radix Parthenocissi Heterophyllae 2kg, Camphora 0.2kg, ethanol 0.8kg.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, for subsequent use.
Take stearic acid 15g, vaseline 100g, lanoline 80g, glyceryl stearate 35g, hexadecanol 80g, be heated to 85 DEG C, stir evenly, as oil phase, for subsequent use; Separately get glycerol 130g, ethylparaben 2g, sodium lauryl sulphate 20g, laurocapram 25g, add above-mentioned thick paste and volatile oil, water use regulation makes the biphase 1000g altogether of oil, water, as aqueous phase, is heated to 90 DEG C, after all dissolving, constant temperature to 85 DEG C, stirs evenly; Oil phase is slowly added aqueous phase, puts in refiner and stir, cooling, solidifies, subpackage, obtains unguentum of the present invention.
Embodiment 6 unguentum
Take Radix Aconiti 3.5kg, Radix Aconiti Kusnezoffii 3.5kg, Bulbus Allii Fistulosi 1.2kg, blood party 1.8kg, Radix Alangii 1.2kg, Heiguteng exract 2.3kg, red nine Ns of 2.5kg, Radix Parthenocissi Heterophyllae 2kg, Camphora 0.1kg, ethanol 1kg.Extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, makes alcohol content be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, for subsequent use.
Take stearic acid 18g, vaseline 100g, lanoline 80g, glyceryl stearate 30g, hexadecanol 82g, be heated to 85 DEG C, stir evenly, as oil phase, for subsequent use; Separately get glycerol 110g, ethylparaben 4g, sodium lauryl sulphate 30g, laurocapram 30g, add above-mentioned thick paste and volatile oil, water use regulation makes the biphase 1000g altogether of oil, water, as aqueous phase, is heated to 90 DEG C, after all dissolving, constant temperature to 85 DEG C, stirs evenly; Oil phase is slowly added aqueous phase, puts in refiner and stir, cooling, solidifies, subpackage, obtains unguentum of the present invention.
Embodiment 7 powder
Take Radix Aconiti 4.5kg, Radix Aconiti Kusnezoffii 4.5kg, Bulbus Allii Fistulosi 1.5kg, blood party 2.3kg, Radix Alangii 2.5kg, Heiguteng exract 1.8kg, red nine Ns of 2kg, Radix Parthenocissi Heterophyllae 2.5kg, Camphora 0.2kg, ethanol 0.7kg.Pulverize, sieve, to obtain final product.
Efficacy assessments and clinical trial are summed up
1 basic document
Observe hyperosteogeny patient 75 example, man 32 example, female 43 example, age 32-75 year, the course of disease gets rid of gestation and women breast-feeding their children, those who are allergic to this drug, late deformity, maimed person, disability person.Patient all haves a medical check-up through x-ray and is diagnosed as hyperosteogeny of cervical vertebra 45 example, lumbar vertebra hyperosteogeny 30 example.
2 Therapeutic Method
With the emplastrum of the embodiment of the present invention 3, stick affected part, repeated multiple times, within 2 weeks, be 1 course for the treatment of, after observing treatment, symptom changes situation, administration time 1 month-3 months.
3 curative effect judging standards
Recovery from illness: clinical symptom disappearance, freely, x line check bone matrix hyperplasia does not have growth to local movement, follows up a case by regular visits to without recurrence after 1 year.
Effective: clinical symptoms disappears substantially, local movement is without obviously limited.
Effective: clinical symptoms is obviously improved, tired or can symptom be occurred after catching cold, but comparatively before alleviate to some extent, lighter work can be participated in.
Invalid: 2 ~ 3 courses for the treatment of are treated in medication, clinical symptoms is improved not obvious, and joint movement disorder is unchanged, very then increases the weight of.
4 the results are shown in Table 1.
Table 1 efficacy result
Recovery from illness Effective Effectively Invalid Effective percentage (%)
Curative effect 16 35 21 3 96.0
Clinical effectiveness shows: the total effective rate of Chinese medicine composition to cervical vertebra, lumbar vertebra hyperosteogeny patient that the present invention treats waist hyperosteogeny of cervical vertebra is 96.0%, and result shows, the present invention has the curative effect of good treatment waist hyperosteogeny of cervical vertebra.
Model case:
Case 1: Wu X, female, 40 years old.Often have dizziness, nauseating, symptoms of emesis, makes a definite diagnosis hyperosteogeny of cervical vertebra through hospital, gives the embodiment of the present invention 5 and treats, and treats March, dizzy, feels sick, and symptoms of emesis disappears, and continue to strengthen and treat January, after 1 year, further consultation cannot be sent out, and follows up a case by regular visits to better so far.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (7)

1. treat a Chinese medicine composition for waist hyperosteogeny of cervical vertebra, it is characterized in that it comprises being prepared from by the raw material of following weight portion: Radix Aconiti 20-60 part, Radix Aconiti Kusnezoffii 20-60 part, Bulbus Allii Fistulosi 5-20 part, blood party 10-30 part, Radix Alangii 10-30 part, Heiguteng exract 10-30 part, red nine Ns of 10-30 parts, Radix Parthenocissi Heterophyllae 10-30 part, Camphora 1-3 part, ethanol 5-15 part.
2. the Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra as claimed in claim 1, is characterized in that it is prepared from by the raw material comprising following weight portion: Radix Aconiti 30-50 part, Radix Aconiti Kusnezoffii 30-50 part, Bulbus Allii Fistulosi 10-15 part, blood party 15-25 part, Radix Alangii 15-25 part, Heiguteng exract 15-25 part, red nine Ns of 15-25 parts, Radix Parthenocissi Heterophyllae 15-25 part, Camphora 1-2 part, ethanol 5-10 part.
3. the Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra as claimed in claim 1 or 2, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
4. the Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
5. the Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
6. the Chinese medicine composition for the treatment of waist hyperosteogeny of cervical vertebra as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, alcohol content is made to be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtain active component.
7. treat a Chinese medicine composition for waist hyperosteogeny of cervical vertebra, be prepared from by the Chinese medicine composition of the treatment waist hyperosteogeny of cervical vertebra described in claim 1 or 2 and pharmaceutically acceptable carrier combination.
CN201610033115.XA 2016-01-19 2016-01-19 Traditional Chinese medicinal composition for treating lumbar and cervical bone hyperplasia and preparation method thereof Pending CN105535389A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106177662A (en) * 2016-08-16 2016-12-07 余昌仕 A kind of treat prominent Chinese medicine composition of hyperosteogeny, intercalated disc and preparation method thereof
CN110946973A (en) * 2019-12-31 2020-04-03 武汉市蔡氏福宁中草药有限公司 Chinese medicinal material extract and preparation method thereof

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CN101112491A (en) * 2007-08-23 2008-01-30 余以正 Externally-used drug for treating hyperosteogeny and method for preparing the same

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CN101112491A (en) * 2007-08-23 2008-01-30 余以正 Externally-used drug for treating hyperosteogeny and method for preparing the same

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106177662A (en) * 2016-08-16 2016-12-07 余昌仕 A kind of treat prominent Chinese medicine composition of hyperosteogeny, intercalated disc and preparation method thereof
CN110946973A (en) * 2019-12-31 2020-04-03 武汉市蔡氏福宁中草药有限公司 Chinese medicinal material extract and preparation method thereof

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