CN1876034A - An externally applied analgetic and preparation method thereof - Google Patents
An externally applied analgetic and preparation method thereof Download PDFInfo
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- CN1876034A CN1876034A CN 200610010832 CN200610010832A CN1876034A CN 1876034 A CN1876034 A CN 1876034A CN 200610010832 CN200610010832 CN 200610010832 CN 200610010832 A CN200610010832 A CN 200610010832A CN 1876034 A CN1876034 A CN 1876034A
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an externally-used analgesic medicament, which is prepared from Kusnezoff monkshood root, shortstalk monkshood root, star aniseed, Eucalyptus globules leaf, notoginseng, Eriosema himalaicum Ohashi and drynaria by a predetermined weight proportions.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly, the present invention relates to a kind of externally applied analgetic and preparation method thereof.
Background technology
Pain is one of clinical modal symptom, usually perplexs and is tormenting the patient, has a strong impact on patient's orthobiosis.For pain is alleviated, adopt approach such as taking, inject Western medicine or use externally applied analgetic orally to solve usually.Existing Western medicine often reaches pain relieving by approach such as narcotic analgesic (as morphine, codeine, pethidine hydrochloride, methadone etc.), analgesic anti-inflammatory analgesic (as Ah woods, ibuprofen etc.), anxiety pain relievings (as Benzodiazepines etc.), patient's medication inconvenience, all there is untoward reaction in various degree, may produce addiction and dependency, and only be a kind of method of respite clinical symptoms, and having the Chinese medicine analgesic now based on decoction and unguentum, curative effect preparation preferably is rarely found.The present invention is according to Traditional Chinese medical theory, and scientific composition reaches aim of alleviating pain by blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, and external has no side effect, and has effectively remedied the deficiency of existing analgesic drug product.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of more efficiently externally-used pain-relieving medicine is provided.
Another object of the present invention provides the preparation method of described externally-used pain-relieving medicine.
Solution of the present invention is based on motherland's medical science the mechanism and the Therapeutic Principle of pain is proposed.According to theory of Chinese medical science, pain often is obstructed because of the mechanism of qi of certain one in patient's body, network road obturation, battalion defend smooth due to.All external pathogens immerse human body, and the visitor is in skin or be stranded in meridians; Or frustrate the wound blood stasis by falling to wink; Or by overaction of the five emotions, disturb in the seven emotions, and factor such as phlegm-damp cohesion causes depression and stagnation of QI or pent-up, all can make us body network road and block, blood fortune is not smooth, thereby causes pain.Huangdi's Internal Classics is said: " general rule not bitterly, pain then not bitterly ".Therefore, the treatment of pain principle should be to want with " leading to ", promptly uses circulation of qi promoting, invigorates blood circulation, and methods such as collateral dredging are circulated and alleviating pain meridian qi and blood.
Purpose of the present invention is achieved by following technical proposals.
☆ except as otherwise noted, the percent that is adopted among the present invention is percetage by weight.
The invention provides a kind of externally-used pain-relieving medicine, this medicament selection Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Herba Piperris Tonkinensis, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat pain.Wherein the outer scraper of Radix Aconiti Kusnezoffii and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) has significant analgesia, invigorates blood circulation and improves the effect of local microcirculation; Being aided with Radix Alangii is local muscle relaxant, but eliminating stasis to stop pain helps analgesic at partial penetrating Absorption; The Herba Piperris Tonkinensis analgesia of dispeling the wind; The Radix Notoginseng dissipating blood stasis for subsidence of swelling, hemostasis is invigorated blood circulation; MIANDAJI detumescence hemostasis helps the healing of wound tissue; The Caulis et Radix Periplocae Forrestii relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic; The continuous wound of Rhizoma Drynariae eased pain; The number medicine is 5 usefulness mutually, can strengthen the analgesic effect of Radix Aconiti Kusnezoffii and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani).
In order to reach better therapeutic, medicine of the present invention also makes up with Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Caulis Sargentodoxae, Flos Carthami.The Caulis Fibraureae heat-clearing and toxic substances removing, local antiinflammatory effect is remarkable, and the compatibility Caulis Fibraureae is to improve the anti-trauma infection contamination effect of medicine of the present invention; The Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) removing blood stasis to reduce swelling, the synthetism hemostasis; The Caulis Sargentodoxae expelling wind and activating blood circulation, heat-clearing and toxic substances removing; The Flos Carthami blood circulation promoting and blood stasis dispelling, pain relieving; All medicines cooperate, and have strengthened detumescence and analgesic and have renderd a service.
In order to obtain optimum curative effect, medicine of the present invention can also add Borneolum Syntheticum (C on the basis of said medicine
10H
18O).At this moment because of Borneolum Syntheticum nature and flavor suffering, hardship, be slightly cold.GUIXIN, spleen, lung meridian.The refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.It both can help the fraud of the big heat of all medicines of system, but priming reaches hole key skin thoroughly again.This 13 flavor medicine is made up detumescence and analgesic curative effect the best.
The consumption of drug component of the present invention draws through groping in a large number to sum up, and each amounts of components is for all to have better curative effect in the following weight parts scope:
60～100 parts of Radix Aconiti Kusnezoffii, 20～60 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 10～40 parts of Radix Alangiis, 20～70 parts of Herba Piperris Tonkinensiss, 10～40 parts of Radix Notoginseng, 20～70 parts of Radix Stelleraes, 20～60 parts of Caulis et Radix Periplocae Forrestiis, 20～60 parts of Rhizoma Drynariae.
Be preferably: 84 parts of Radix Aconiti Kusnezoffii, 44 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 20 parts of Radix Alangiis, 52 parts of Herba Piperris Tonkinensiss, 20 parts of Radix Notoginseng, 48 parts of Radix Stelleraes, 44 parts of Caulis et Radix Periplocae Forrestiis, 40 parts of Rhizoma Drynariae.
Each amounts of components of medicine of the present invention can also be 60～100 parts of Radix Aconiti Kusnezoffii, 20～60 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 10～40 parts of Radix Alangiis, 20～70 parts of Herba Piperris Tonkinensiss, 10～40 parts of Radix Notoginseng, 20～70 parts of Radix Stelleraes, 20～60 parts of Caulis et Radix Periplocae Forrestiis, 20～60 parts of Rhizoma Drynariae, 10～50 parts of Caulis Fibraureaes, 20～70 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae)s, 20～60 parts of Caulis Sargentodoxae, 10～30 parts on Flos Carthami.
Be preferably: 84 parts of Radix Aconiti Kusnezoffii, 44 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 20 parts of Radix Alangiis, 52 parts of Herba Piperris Tonkinensiss, 20 parts of Radix Notoginseng, 48 parts of Radix Stelleraes, 44 parts of Caulis et Radix Periplocae Forrestiis, 40 parts of Rhizoma Drynariae, 30 parts of Caulis Fibraureaes, 40 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae)s, 40 parts of Caulis Sargentodoxae, 16 parts on Flos Carthami.
The medicine of the present invention further consumption of each component is 60～100 parts of Radix Aconiti Kusnezoffii, 20～60 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 10～40 parts of Radix Alangiis, 20～70 parts of Herba Piperris Tonkinensiss, 10～40 parts of Radix Notoginseng, 20～70 parts of Radix Stelleraes, 20～60 parts of Caulis et Radix Periplocae Forrestiis, 20～60 parts of Rhizoma Drynariae, 10～50 parts of Caulis Fibraureaes, 20～70 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae)s, 20～60 parts of Caulis Sargentodoxae, 10～30 parts on Flos Carthami, 1～5 part of Borneolum Syntheticum.
Be preferably: 84 parts of Radix Aconiti Kusnezoffii, 44 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 20 parts of Radix Alangiis, 52 parts of Herba Piperris Tonkinensiss, 20 parts of Radix Notoginseng, 48 parts of Radix Stelleraes, 44 parts of Caulis et Radix Periplocae Forrestiis, 40 parts of Rhizoma Drynariae.30 parts of Caulis Fibraureaes, 40 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae)s, 40 parts of Caulis Sargentodoxae, 16 parts on Flos Carthami, 2 parts of Borneolum Syntheticums.
Radix Aconiti Kusnezoffii described in the present invention is: the dried root of ranunculaceae plant Dendrobium denneanum Kerr. crow Aconitum vilmorinianumKom or South Yunnan Radix Aconiti Kusnezoffii A.austroyunnanense W.T.Wang.
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) described in the present invention is: the dried root of ranunculaceae plant Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) Aconitumbrachypodum Diels.
Radix Alangii described in the present invention is: the dried root of Alangiaceae plant Radix Alangii Alangium chinense (Lour.) Harms.Fibrous root is called " Radix Alangii ", and lateral root is called " platinum bar ".
Herba Piperris Tonkinensis described in the present invention is: dry stem, the leaf of Piperaceae plant Herba Piperris Tonkinensis Piper boehmerifoliumWall.var.tonkinense C.DC..
Caulis et Radix Periplocae Forrestii described in the present invention is: dry old stem and the root of asclepiadaceae plant Caulis et Radix Periplocae Forrestii Periploca forrestiiSchltr. and blue or green mabi Periploca calophylla (Wight) Falc..
MIANDAJI described in the present invention is: the dry root of thymelaeceae plant cotton Radix Euphorbiae Pekinensis Stellera chamaejasme L..
Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) described in the present invention is: the dry root of the full edge chu lan tree of Chloranthaceae plant Chioranthushoiostegius (Hand.Mazz.) P.ei et Shan.
Medicine of the present invention is according to character of medicinal material, and based on heat reflow method, the preparation technology of bound fraction medical material percolation combines the extraction advantage of heat reflow method and percolation.Color and luster was bright when Herba Piperris Tonkinensis and Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) medical material contained pigment in volatile oil, the Flos Carthami and be dissolved in the cold alcohol in the drug component of the present invention, so with Herba Piperris Tonkinensis, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Flos Carthami employing ethanol percolate extraction.All the other medical materials contain alkaloid and glycoside (Saponin and cardiotonic glycoside) adopts alcohol heat reflux to extract.
Preferably, medicine activity component preparation method of the present invention is as follows:
(1) Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Herba Piperris Tonkinensis, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, each medical material of Rhizoma Drynariae with described weight proportion is ground into coarse powder respectively, and be standby;
(2) Herba Piperris Tonkinensis is added 60%～80% ethanol, carry out percolation by percolation, the liquid of filtering merges, and filter is to clear and bright, standby;
(3) with the coarse powder mixing of the Radix Aconiti Kusnezoffii of described weight proportion, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, add 60%～80% ethanol, refluxed 4～6 hours, put cold, emit backflow just, medicinal residues repeat to reflux 2～3 times, each 2～3 hours, merge backflow, after being concentrated into appropriate volume, with the abundant mixing of first backflow, filter is to clear and bright, standby;
(4) with above-mentioned percolate and the abundant mix homogeneously of backflow, leave standstill 3～5 days after, filter promptly gets effective ingredient of the present invention to clear and bright.
If also with Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Caulis Sargentodoxae, Flos Carthami combination, its preparation method is:
(1) Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Herba Piperris Tonkinensis, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), each medical material of Caulis Sargentodoxae with described weight proportion is ground into coarse powder respectively, and be standby;
(2) it is an amount of Herba Piperris Tonkinensis, the Flos Carthami of described weight proportion to be added 60%～80% ethanol, carries out percolation by percolation, and the liquid of filtering merges, and filter is to clear and bright, standby;
(3) with Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), the Caulis Sargentodoxae coarse powder mixing of described weight proportion, add 60%～80% ethanol, refluxed 4～6 hours, put cold, emit backflow just, medicinal residues repeat to reflux 2～3 times, each 2～3 hours, merge backflow, after being concentrated into appropriate volume, with the abundant mixing of first backflow, filter is to clear and bright, standby;
(4) with percolate and the abundant mix homogeneously of backflow, leave standstill 3～5 days after, filter is to clear and bright.Promptly get effective ingredient of the present invention.
If also add Borneolum Syntheticum, the preparation method of medicine of the present invention is:
(1) Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Herba Piperris Tonkinensis, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), each medical material of Caulis Sargentodoxae with described weight proportion is ground into coarse powder respectively, and be standby;
(2) with Herba Piperris Tonkinensis, add 60%～80% ethanol, carry out percolation by percolation, the liquid of filtering merges, filter is to clear and bright, standby;
(3) with Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), the Caulis Sargentodoxae coarse powder mixing of described weight proportion, it is an amount of to add 60%～80% ethanol, refluxes 4～6 hours, puts cold, emit backflow just, medicinal residues repeat to reflux 2～3 times, each 2～3 hours, merge backflow, after being concentrated into appropriate volume, with the abundant mixing of first backflow, filter is to clear and bright, standby;
(4) with 1～5 part of the Borneolum Syntheticum of described weight proportion and above-mentioned percolate, the abundant mix homogeneously of backflow, leave standstill 3～5 days after, filter promptly gets effective ingredient of the present invention to clear and bright.
Effective ingredient of the present invention can further adopt the conventional method of Chinese medicine preparation to be prepared into suitable external preparations, as liniment, aerosol, spray, emplastrum.
Behind effective constituent determination ethanol content of the present invention, according to the concentration of alcohol that determines, add suitable solvent to full dose, making and adjusting medicinal liquid to the ethanol of stipulating 50%～70% that contains is degree, fully mixing.Filter is to clear and bright, and liniment is made in fill.
Ethanol content in the effective ingredient of the present invention is adjusted to 50%～70% is degree, fully mixing.Filter is to clear and bright, add an amount of propellant after, mutual encapsulation is made aerosol in having the pressure vessel of special valving.
Ethanol content in the effective ingredient of the present invention is adjusted to 50%～70% is degree, fully mixing.Filter is encapsulated in the pressure vessel with special valving to clear and bright, makes spray.
With the abundant mixing of effective ingredient of the present invention, filter with suitable substrate mixing, is coated and is made emplastrum on the back lining materials behind the cryoconcentration to clear and bright.
Compared with prior art, the present invention has following distinguishing feature:
(1) relieving pain of the present invention, active constituents of medicine can reach key skin depths, hole thoroughly, and the patient is carried out the pain relieving of human body deep layer.
(2) safety non-toxic of the present invention has evident in efficacy, short treating period, characteristics such as easy to use, has better market prospect.
(3) raw material uniqueness of the present invention, preparation technology are simple, can effectively reduce drug price.
Below by toxicity and pharmacological tests, advantage of the present invention is described further.
1. acute toxicity test: to the mouse skin administration,, can't measure LD because acute toxicity of the present invention is very little with effective ingredient of the present invention
50, every day, maximum tolerated dose was 100ml/ kilogram (a 48g crude drug/kilogram), was 200 times of human dosage, mice shows no abnormal situation.
2. long term toxicity test: with effective ingredient of the present invention the rabbit local skin is coated with continuously and puts 28 days on the skin, total amount is equivalent to 333～666 times of clinical every day of consumption, all in normal range, the coating local skin and the heart, liver, spleen, lung, kidney, thyroid, pancreas, stomach, small intestinal, large intestine, thymus, adrenal gland, testis, uterus, ovary etc. there is no unusually for routine blood test, liver, renal function and other biochemical indicators.
3. skin anaphylactic test: carry out the sensitization experiment with Cavia porcellus, the result shows that medicine of the present invention does not have sensitization.
4. skin irritation test: disposable and muptiple-use (1 time/day, 6 hours/time, totally 10 days) stimulation test is carried out in administration to the rabbit skin, and the result shows medicine no abnormality seen of the present invention.
Clinical test results:
(1) tolerance test
Clinical application situation 1～5ml/ time, 5～10ml/ time, continuous use 7 days.Adopt 1/4,1/2,1,2,3,6 times of former dosage as test dose, promptly be divided into 6 test group, totally 30 routine experimenters.Result of the test is as shown in table 1.
Table 1.
| Test group | 1 consumption | Daily number of times | Consumption per day | The medication natural law | Experimenter's number |
| The 1st group | 1.25ml | 4 times | 5ml | 1 day | 4 people |
| The 2nd group | 2.50ml | 4 times | 10ml | 1 day | 4 people |
| The 3rd group | 5.0ml | 4 times | 20ml | 1 day | 4 people |
| The 4th group | 5.0ml | 6 times | 30ml | 2 days | 6 people |
| The 5th group | 5.0ml | 8 times | 40ml | 4 days | 6 people |
| The 6th group | 5.0ml | 8 times | 40ml | 7 days | 6 people |
Apply medicinal lotion or ointment by experimenter's forearm inside skin, test in strict accordance with testing program, security inspection carries out systematic observation after observing vital sign, untoward reaction, local skin safety indexes, medication, do not see the performance of untoward reaction symptom and aconitine poisoning symptom, body temperature changes at 0～0.1 ℃, the dynamic change of heart rate, pulse, breathing, systolic pressure, diastolic pressure all in normal range.Security inspection is normally, there are 3 routine experimenter's electrocardiogram abscissas to shorten for the P-R interval, diagnose jointly through electrocardiogram doctor and Vasculocardiology Deparment doctor, belong to normal ECG, 1 routine haemanalysis abscissa WBC fluctuates 10.1 from 6.6, and BUN fluctuates 7096 from 6.0, all a little more than normal value, all the other experimenters all do not have the normal range of exceeding at aspects such as vital sign, drug safety inspections, do not find the untoward reaction symptom.The tolerance test that this shows medicine of the present invention does not cause the unusual of experimenter's vital sign, security inspection, does not cause the untoward reaction symptom.Mode medication by medication 7 days, 5.0ml/ time, every day 8 times, topical administration is safe.
(2) treatment acute soft tissue injury, rheumatoid arthritis 288 routine clinical observations
According to the result of a clinical trial phase, the dosage and course of treatment of II clinical trial phase is decided to be: every day 3 times, 1～5.0ml/ time, 5 days courses of treatment.By the single at random blind contrast clinical trial of the multicenter of 288 examples, objective evaluation the present invention treats various pain effectiveness and the safety that rheumatic arthritis, bones and muscles pain due to rheumatism and traumatic injury (qi depression to blood stasis or double wind and cold arthromyodynia) cause, its detumescence of primary part observation, pain relieving, improves the curative effect of movable function.
Clinical test results shows:
1. treatment acute soft tissue injury: total effects (cure rate 2.86%, obvious effective rate 35.71%, effective percentage 60.00%, total effective rate 98.57%); Clinical symptoms, sign curative effect (local pain disappearance rate 17.14%, local swelling disappearance rate 41.79%, local tenderness disappearance rate 14.29%, the limited disappearance rate 53.73% of limb activity, skin ecchymosis disappearance rate 32.20%).
2. treatment rheumatoid arthritis: total effects (cure rate 0.0%, obvious effective rate 9.73%, effective percentage 58.33%, total effective rate 68.06%); Clinical symptoms, sign curative effect (local pain disappearance rate 12.50%, local swelling disappearance rate 27.94%, local tenderness disappearance rate 19.44%, the limited disappearance rate 14.06% of limb activity, morning stiff disappearance rate 5.63%, pain pain increase in intensity under coldness disappearance rate 16.67%).
3. treat cancerous pain 56 examples
The indignant condition of patient: advanced malignant tumor patient 56 examples, all cases all have the pain of the distinct program that causes because of cancerous protuberance.Male's 39 examples wherein, women's 17 examples; Minimum 32 years old of age, maximum 81 years old, 61 years old mean age.The present invention is coated with in right amount spills on gauze, wiped in the relaxing tumor pain position each 5ml, every day 3～4 times repeatedly 3～4 minutes.Total pain relief 18 examples are alleviated 32 examples, invalid 6 examples, and total effective rate is 89.3%.5 minutes～1 hour onset time, mostly be 15～30 minutes; Effective time 1～6 hour, middle bit time are 4 hours; Total remission time 1～52 hour, middle bit time is 8.5 hours.
Clinical trial confirms: the present invention treats pain and the cancerous pain total effective rate that acute soft tissue injury, rheumatoid arthritis cause and is respectively 98.57%, 68.06% and 89.3%.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail, but owing to the present invention can summarize with other concrete forms without prejudice to principal character of the present invention.Therefore, illustrated embodiment just can not limit the present invention to explanation of the present invention.
Embodiment 1
Take by weighing Radix Aconiti Kusnezoffii 60g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20g, Radix Alangii 10g, Herba Piperris Tonkinensis 30g, Radix Notoginseng 10g, Caulis et Radix Periplocae Forrestii 20g, Rhizoma Drynariae 20g, Radix Stellerae 20g by recipe quantity.
Earlier become coarse powder standby each medical material pulverize separately.It is an amount of that the Herba Piperris Tonkinensis coarse powder is added 60%～80% ethanol, carries out percolation by percolation, and the liquid of filtering merges, and filter is to clear and bright, standby.Behind all the other medicinal material coarse powder mixings, an amount of with 60～80% ethanol, refluxed 3～5 hours, to put coldly, filter is to clear and bright.Percolate is mixed with backflow, make effective ingredient.
Mensuration contains the alcohol amount, and according to the concentration that contains the alcohol amount, the ethanol that adds suitable concentration was placed 3～5 days to full dose, and filter is to clear and bright, and liniment is made in fill.
Ethanol content in the above-mentioned effective ingredient is adjusted to 50%～70% is degree, fully mixing.Filter is to clear and bright, add an amount of propellant after, mutual encapsulation is made aerosol in having the pressure vessel of special valving.
Ethanol content in the above-mentioned effective ingredient is adjusted to 50%～70% is degree, fully mixing.Filter is encapsulated in the pressure vessel with special valving to clear and bright, makes spray.
With the abundant mixing of above-mentioned effective ingredient.Filter with suitable substrate mixing, is coated and is made emplastrum on the back lining materials behind the cryoconcentration to clear and bright.
Embodiment 2
Repeat embodiment 1, following difference is arranged: take by weighing Radix Aconiti Kusnezoffii 80g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40g, Radix Alangii 20g, Herba Piperris Tonkinensis 40g, Radix Notoginseng 20g, Caulis et Radix Periplocae Forrestii 40g, Rhizoma Drynariae 40g, Radix Stellerae 45g by recipe quantity.
Embodiment 3
Repeat embodiment 1, following difference is arranged: take by weighing Radix Aconiti Kusnezoffii 100g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 60g, Radix Alangii 40g, Herba Piperris Tonkinensis 70g, Radix Notoginseng 40g, Caulis et Radix Periplocae Forrestii 60g, Rhizoma Drynariae 60g, Radix Stellerae 70g by recipe quantity.
Embodiment 4
Repeat embodiment 1, following difference is arranged: take by weighing Radix Aconiti Kusnezoffii 60g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20g, Radix Alangii 10g, Herba Piperris Tonkinensis 30g, Radix Notoginseng 10g, Caulis et Radix Periplocae Forrestii 20g, Rhizoma Drynariae 20g, Radix Stellerae 20g, Caulis Fibraureae 10g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 20g, Caulis Sargentodoxae 20g, Flos Carthami 10g by recipe quantity.
Earlier become coarse powder standby each medical material pulverize separately.It is an amount of that Herba Piperris Tonkinensis, Flos Carthami are added 60～80% ethanol, carries out percolation by percolation, and the liquid of filtering merges, and filter is to clear and bright, standby.Behind all the other medicinal material coarse powder mixings, an amount of with 60～80% ethanol, refluxed 3～5 hours, to put coldly, filter is to clear and bright.Percolate is mixed with backflow, make effective ingredient.
Embodiment 5
Repeat embodiment 1, following difference is arranged: take by weighing Radix Aconiti Kusnezoffii 80g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40g, Radix Alangii 20g, Herba Piperris Tonkinensis 40g, Radix Notoginseng 20g, Caulis et Radix Periplocae Forrestii 40g, Rhizoma Drynariae 40g, Radix Stellerae 45g, Caulis Fibraureae 20g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 30g, Caulis Sargentodoxae 30g, Flos Carthami 20g by recipe quantity.
Embodiment 6
Repeat embodiment 1, following difference is arranged: take by weighing Radix Aconiti Kusnezoffii 100g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 60g, Radix Alangii 40g, Herba Piperris Tonkinensis 70g, Radix Notoginseng 40g, Caulis et Radix Periplocae Forrestii 60g, Rhizoma Drynariae 60g, Radix Stellerae 70g, Caulis Fibraureae 50g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 70g, Caulis Sargentodoxae 60g, Flos Carthami 30g by recipe quantity.
Embodiment 7
Repeat embodiment 6, following difference is arranged: Borneolum Syntheticum 1g and percolate, backflow are mixed, make effective ingredient.
Embodiment 8
Repeat embodiment 6, following difference is arranged: Borneolum Syntheticum 2g and percolate, backflow are mixed, make effective ingredient.
Embodiment 9
Repeat embodiment 6, following difference is arranged: Borneolum Syntheticum 3g and percolate, backflow are mixed, make effective ingredient.
Embodiment 10
Repeat above-mentioned enforcement 6, following difference is arranged: Borneolum Syntheticum 5g and percolate, backflow are mixed, make effective ingredient.
Claims (10)
1. an externally applied analgetic is characterized in that the primary raw material medicine composition of making this pharmaceutically active ingredient is by weight: 60～100 parts of Radix Aconiti Kusnezoffii, 20～60 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 10～40 parts of Radix Alangiis, 20～70 parts of Herba Piperris Tonkinensiss, 10～40 parts of Radix Notoginseng, 20～70 parts of Radix Stelleraes, 20～60 parts of Caulis et Radix Periplocae Forrestiis, 20～60 parts of Rhizoma Drynariae.
2. according to the medicine of claim 1, wherein the consumption of each crude drug is: 84 parts of Radix Aconiti Kusnezoffii, 44 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 20 parts of Radix Alangiis, 52 parts of Herba Piperris Tonkinensiss, 20 parts of Radix Notoginseng, 48 parts of Radix Stelleraes, 44 parts of Caulis et Radix Periplocae Forrestiis, 40 parts of Rhizoma Drynariae.
3. the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
(1) Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Herba Piperris Tonkinensis, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, each medical material of Rhizoma Drynariae with described weight proportion is ground into coarse powder respectively, and be standby;
(2) Herba Piperris Tonkinensis is added 60%～80% ethanol, carry out percolation by percolation, the liquid of filtering merges, and filter is to clear and bright, standby;
(3) with the coarse powder mixing of the Radix Aconiti Kusnezoffii of described weight proportion, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, add 60%～80% ethanol, refluxed 4～6 hours, put cold, emit backflow just, medicinal residues repeat to reflux 2～3 times, each 2～3 hours, merge backflow, after being concentrated into appropriate volume, with the abundant mixing of first backflow, filter is to clear and bright, standby;
(4) with above-mentioned percolate and the abundant mix homogeneously of backflow, leave standstill 3～5 days after, filter promptly gets the active component of medicine of the present invention to clear and bright.
4. medicine according to claim 1, wherein crude drug also has 10～50 parts of Caulis Fibraureaes, 20～70 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae)s, 20～60 parts of Caulis Sargentodoxae, 10～30 parts on Flos Carthami.
5. medicine according to claim 4, wherein the consumption of each component is: 84 parts of Radix Aconiti Kusnezoffii, 44 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 20 parts of Radix Alangiis, 52 parts of Herba Piperris Tonkinensiss, 20 parts of Radix Notoginseng, 48 parts of Radix Stelleraes, 44 parts of Caulis et Radix Periplocae Forrestiis, 40 parts of Rhizoma Drynariae, 30 parts of Caulis Fibraureaes, 40 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae)s, 40 parts of Caulis Sargentodoxae, 16 parts on Flos Carthami.
6. the preparation method of claim 4 or 5 described medicines, it comprises the following steps:
(1) Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Herba Piperris Tonkinensis, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), each medical material of Caulis Sargentodoxae with described weight proportion is ground into coarse powder respectively, and be standby;
(2) it is an amount of Herba Piperris Tonkinensis, the Flos Carthami of described weight proportion to be added 60%～80% ethanol, carries out percolation by percolation, and the liquid of filtering merges, and filter is to clear and bright, standby;
(3) with Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), the Caulis Sargentodoxae coarse powder mixing of described weight proportion, add 60%～80% ethanol, refluxed 4～6 hours, put cold, emit backflow just, medicinal residues repeat to reflux 2～3 times, each 2～3 hours, merge backflow, after being concentrated into appropriate volume, with the abundant mixing of first backflow, filter is to clear and bright, standby;
(4) with percolate and the abundant mix homogeneously of backflow, leave standstill 3～5 days after, filter is to clear and bright.Promptly get effective ingredient of the present invention.
7. medicine according to claim 4 wherein also has in the crude drug: 1～5 part of Borneolum Syntheticum.
8. medicine according to claim 7, wherein the consumption of each component is: 2 parts of 84 parts of Radix Aconiti Kusnezoffii, 44 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 20 parts of Radix Alangiis, 52 parts of Herba Piperris Tonkinensiss, 20 parts of Radix Notoginseng, 48 parts of Radix Stelleraes, 44 parts of Caulis et Radix Periplocae Forrestiis, 40 parts of Rhizoma Drynariae, 30 parts of Caulis Fibraureaes, 40 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae)s, 40 parts of Caulis Sargentodoxae, 16 parts on Flos Carthami and Borneolum Syntheticums.
9. the preparation method of claim 7 or 8 described medicines, it comprises the following steps:
(1) Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Herba Piperris Tonkinensis, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), each medical material of Caulis Sargentodoxae with described weight proportion is ground into coarse powder respectively, and be standby;
(2) the Herba Piperris Tonkinensis and Flos Carthami is added 60%～80% ethanol, carry out percolation by percolation, the liquid of filtering merges, and filter is to clear and bright, standby;
(3) with Radix Aconiti Kusnezoffii, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Alangii, Radix Notoginseng, Radix Stellerae, Caulis et Radix Periplocae Forrestii, Rhizoma Drynariae, Caulis Fibraureae, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), the Caulis Sargentodoxae coarse powder mixing of described weight proportion, it is an amount of to add 60%～80% ethanol, refluxes 4～6 hours, puts cold, emit backflow just, medicinal residues repeat to reflux 2～3 times, each 2～3 hours, merge backflow, after being concentrated into appropriate volume, with the abundant mixing of first backflow, filter is to clear and bright, standby;
(4) with 1～5 part of the Borneolum Syntheticum of described weight proportion and above-mentioned percolate, the abundant mix homogeneously of backflow, leave standstill 3～5 days after, filter promptly gets required active component to clear and bright.
10. preparation method according to claim 9, wherein add an amount of propellant in the active component that step (4) is made after, mutual encapsulation is made aerosol in having the pressure vessel of special valving; Perhaps its branch is encapsulated in the pressure vessel with special valving, makes spray; Perhaps with behind its cryoconcentration with suitable substrate mixing, coat and make emplastrum on the back lining materials.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102008576A (en) * | 2010-11-29 | 2011-04-13 | 昆明理工大学 | External traditional Chinese medicine for treating sprain and preparation method thereof |
| CN103083489A (en) * | 2013-01-24 | 2013-05-08 | 王林祥 | Traditional Chinese medicine wine for treating lumbar spondylosis, cervical spondylosis, early osteoproliferation and old wounds |
| CN104042815A (en) * | 2014-06-28 | 2014-09-17 | 张志全 | Traditional Chinese medicine plaster for treating cancer pain |
| CN104353023A (en) * | 2014-10-21 | 2015-02-18 | 苏州仁捷瑞自动化科技有限公司 | Bonesetting ointment paste with promoting blood circulation and preparation method thereof |
| CN106389742A (en) * | 2016-10-09 | 2017-02-15 | 上海民生志远健康管理科技发展有限公司 | Traditional Chinese medicine composition for curing cancer pain |
| CN114832055A (en) * | 2022-01-12 | 2022-08-02 | 贵州中医药大学 | Preparation method and application of medicine for controlling cancer pain |
Family Cites Families (1)
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| CN1403123A (en) * | 2002-10-19 | 2003-03-19 | 吉林省辉南长龙生化药业股份有限公司 | Notoginseng medicine for treating traumatic injury and its prepn |
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- 2006-04-19 CN CNB2006100108327A patent/CN100368002C/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008576A (en) * | 2010-11-29 | 2011-04-13 | 昆明理工大学 | External traditional Chinese medicine for treating sprain and preparation method thereof |
| CN103083489A (en) * | 2013-01-24 | 2013-05-08 | 王林祥 | Traditional Chinese medicine wine for treating lumbar spondylosis, cervical spondylosis, early osteoproliferation and old wounds |
| CN104042815A (en) * | 2014-06-28 | 2014-09-17 | 张志全 | Traditional Chinese medicine plaster for treating cancer pain |
| CN104353023A (en) * | 2014-10-21 | 2015-02-18 | 苏州仁捷瑞自动化科技有限公司 | Bonesetting ointment paste with promoting blood circulation and preparation method thereof |
| CN106389742A (en) * | 2016-10-09 | 2017-02-15 | 上海民生志远健康管理科技发展有限公司 | Traditional Chinese medicine composition for curing cancer pain |
| CN114832055A (en) * | 2022-01-12 | 2022-08-02 | 贵州中医药大学 | Preparation method and application of medicine for controlling cancer pain |
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