CN102008576A - External traditional Chinese medicine for treating sprain and preparation method thereof - Google Patents
External traditional Chinese medicine for treating sprain and preparation method thereof Download PDFInfo
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- CN102008576A CN102008576A CN201010562904.5A CN201010562904A CN102008576A CN 102008576 A CN102008576 A CN 102008576A CN 201010562904 A CN201010562904 A CN 201010562904A CN 102008576 A CN102008576 A CN 102008576A
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides an external traditional Chinese medicine for treating sprain, which is characterized by comprising the following raw materials in percentage by mass: 10-40% of sargentgloryvine stem, 8-30% of spreading hedyotis herb, 8-30% of hiraute shiny bugleweed herb, 8-30% of pratia, 5-20% of ramie root, 5-20% of garden balsam stem, 5-20% of gambir plant and 2-10% of shortstalk monkshood root. The medicinal materials are directly smashed into medicinal powder or subject to decoction in various solvents, impregnation, backflow, percolation, ultrasonic process and CO2 critical (subcritical) extraction to extract active ingredients in the medicinal materials; and a proper amount of pharmaceutical excipients is added, and the medicine for external use in forms of tincture, ointment, aerosol, membrane, cataplasm, rubber ointment and the like can be prepared by using a general preparation method. The preparation method is scientific and reasonable, the loss of active ingredients is low, the bioavailability is high, the required equipment is simple, the production period is short and the pollution is prevented. The traditional Chinese medicine provided by the invention has the functions of eliminating local swell and ecchymosis, alleviating pain and recovering functional activities, and has exact curative effect and good effect. Moreover, as the preparation is for external use, the active ingredients of the medicine are absorbed through skin permeation to reach the focus directly, the adverse reaction of general administration, the stimulus to gastrointestinal tract and the medicine toxicity are reduced, and the therapeutic effect of local administration is improved.
Description
Technical field
The present invention relates to external Chinese medicine that a kind of treatment sprains and preparation method thereof, belong to biological pharmacy technical field.
Background technology
Reason causes to sprain (sprain) many, falling down due to careless, tractives improper by strenuous exercise, the posture of bearing a heavy burden when prudent or excessively reverse etc., because joint part is too quickly reversing suddenly, cause soft tissue (as meat fiber, tendon, ligament, the blood vessel etc.) damage of extremities joint or body portion, and do not have situations such as fracture, dislocation, skin and flesh breakage.It is clinical that mainly to show as damage location pain and swelling, ecchymoma and joint motion limited.Tough band portion fibrous fracture takes place in the lighter, and weight person then ligament fibers is ruptured fully, and causes joint dislocation or subluxation, merges sliding desert of intraarticular and cartilage injury simultaneously.Comparatively common at the volley, send out in positions such as waist, ankle, knee joint, shoulder, wrist, elbow, hips.
At present to the conventional treatments of spraining be both at home and abroad: " RICE " (i.e. braking, ice compress, pressure dressing, can raise when extremity are sprained suffer from limb), do the restorative motion of some appropriateness after using the pain relieving of antipyretic-antalgic anti-inflammatory agent thing, pain to slow down.Articular sprain should be fixed in POF, adds plintlet or plaster fixation in case of necessity.The flat bed of then should sleeping behind the lumbar sprain loosens psoas muscle and ligament.The part that other treatment method such as medicine external, medicine are for oral administration, massage, acupuncture, electrotherapy etc. can be used as Comprehensive Treatment.
The effect that has pain relieving and inhibition, alleviates swelling is sprained in treatment by Chinese herbs.The traditional Chinese medical science thinks that spraining is because the external force effect causes impaired, the qi depression to blood stasis of passages through which vital energy circulates.So muscle main motion, the injury of tendon and muscle owner of lost property that then moves is limitation of activity.Select for use have promoting flow of QI and blood, the Chinese crude drug of eliminating blood stasis and smoothing collaterals, reducing swelling and alleviating pain effect carries out reasonable compatibility, preparation prescription science, the Chinese medicine preparation that drug effect is clear and definite can make local swelling, ecchymosis disappear, pain disappears, functional activity recovers.And external preparation makes the effective ingredient of medicine absorb by dermal osmosis, through focus, have efficient, low toxicity, safety, advantage such as convenient, adopt the external preparation percutaneous dosing, can reduce untoward reaction, minimizing GI irritation, the reduction drug toxicity of whole body administration and improve local application's therapeutic effect.
Summary of the invention
The external Chinese medicine that the object of the present invention is to provide a kind of treatment to sprain makes the patient sprain the position local swelling, ecchymosis disappears, and pain disappears, and functional activity recovers.
The external preparation method of Chinese medicine that provides a kind of treatment to sprain is provided another object of the present invention.
The present invention finishes by following technical proposal: the external Chinese medicine that a kind of treatment is sprained is characterized in that being made up of following raw materials by weight percentage:
Caulis Sargentodoxae 10-40%
Herba Hedyotidis Diffusae 8-30%
Herba Lycopi 8-30%
Herba pratiae begonifoliae 8-30%
Radix Boehmeriae 5-20%
Herba speranskiae tuberculatae 5-20%
Ramulus Uncariae Cum Uncis 5-20%
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2-10%
The external Chinese medicine that described treatment is sprained, preferred following raw materials by weight percentage combination, curative effect is better:
Caulis Sargentodoxae 20%
Herba Hedyotidis Diffusae 15%
The Herba Lycopi 15%
Herba pratiae begonifoliae 15%
Radix Boehmeriae 10%
Herba speranskiae tuberculatae 10%
Ramulus Uncariae Cum Uncis 10%
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5%
Wherein, Caulis Sargentodoxae is the dry rattan of Lardizabalaceae plant Caulis Sargentodoxae (Sargentodoxa cuneata (oliv.) Rehd.et wils.).The property hardship, flat.Return large intestine, Liver Channel.Have that heat-clearing and toxic substances removing is invigorated blood circulation, the effect of wind-expelling pain-stopping.Contain emodin, physcione, salidroside, dextrorotation syringaresinol diglucoside, dextrorotation dihydroguaiaretic acid, chrysophanol, Caulis Sargentodoxae polysaccharide etc.This product extract has bacteriostasis, and can suppress thrombosis to antiplatelet aggregation.Be used for abdominalgia with intestinal abscess, pathopyretic ulcer, traumatic injury, amenorrhea dysmenorrhea, rheumatic arthralgia etc.
Herba Hedyotidis Diffusae is the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae (Hedyotis diffusa Willd).Cool in nature, sweet in the mouth, light.Herb contains rubichloric acid., rubichloric acid. acid, goes the acid of acetate rubichloric acid., all square rafter glycoside acid, Herba Paederiae time glycoside, 2-methyl-3-hydroxyanthraquinone and ursolic acid, oleanolic acid etc.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.Be used for tonsillitis, pharyngolaryngitis, urinary tract infection, pelvic inflammatory disease, appendicitis, hepatitis, bacillary dysentery, venom, tumor etc.
The Herba Lycopi is the stem and leaf for labiate hair leaf lycopus lucidus (Lycopus lucidus Turcz.var.hirtus Regel) or lycopus lucidus (Lycopus lucidus Turcz.).Herb contains chemical constituents such as volatile oil, glycoside, tannin and resin, flavonoid glycoside, phenols, aminoacid, organic acid, Saponin, glucose, Herba Lycopi's sugar.The property toil, tepor.Return liver, spleen channel.Effect: promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, line water detumescence.Be usually used in cards such as gynecological's multiparity blood stasis disease and traumatic injury, pain caused by ecchymoma, sore and toxic, edema.
Herba pratiae begonifoliae is the herb of campanulaceae Herba pratiae begonifoliae platymiscium Herba pratiae begonifoliae (Pratia begoniifolia (Wall.) Lindl).Nature and flavor suffering, hardship, flat.Contain higher fatty acids triterpene ester type compound.Effect: expelling wind and removing dampness, promoting blood circulation to remove blood stasis, detoxifcation.Take orally and be used for rheumatalgia, menoxenia, leucorrhea, seminal emission.Conjunctival congestion and swelling pain, traumatic injury, innominate toxic swelling, wound hemorrhage are controlled in external.
Radix Boehmeriae is the root of contrayerva Boehmeria (Boehmeria nivea (Linn.) Gaudich.).Cold in nature, sweet in the mouth.Return liver, the heart, urinary bladder channel.Contain emodin, glycoside.Function cures mainly: clearing away heat and promoting diuresis, antiabortive hemostasis, detoxifcation.Be used for that cold, fever, measles hyperpyrexia, urinary tract infection, oedema due to nephritis, anemia of pregnant woman's stomachache, frequent fetal movement, threatened abortion, traumatic injury, fracture, skin infection swell and ache, hemorrhage etc.
The source plant of Herba speranskiae tuberculatae is mainly euphorbia plant speranskia tuberculata (Speranskia tuberculata (Bunge.) Baill.) or Balsaminaceae plant Impatientis (Impatiens balsamina L.).Wherein Tuberculate Speranskia Herb is the dry herb that has rhizome of speranskia tuberculata, and Caulis Impatientis is the dry stem of Impatientis.Acrid in the mouth, warm in nature.Return lung, Liver Channel.Effect: expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, dissipating blood stasis for subsidence of swelling, detoxifcation ophthalmalgia.Cure mainly: expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, pain relieving.Be used for rheumatic arthralgia, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, skin ulcer tinea toxic swelling.
Ramulus Uncariae Cum Uncis is the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis (Uncaria rhynch0phylla (Miq.) Jacks.), Ramulus Uncariae macrophyllae (Uncaria macrophyllaWall.), Ramulus Uncariae Cum Uncis (Uncaria hirsuta Havil.), Uncaria sinensis (Oliv.) Havil. (Uncaria sinensis (Oliv.) Havil.) or stockless fruit Ramulus Uncariae Cum Uncis (Uncaria sessilifructus Roxb.).Contain chemical constituents such as Ramulus Uncariae cum Uncis alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali, hirsutine, hirsuteine.Cool in nature, sweet in the mouth.Go into liver, heart channel.The effect that has the heat clearing away suppressing the hyperactive liver, relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and calm the frightened.Be used for pediatric epilepsy scared, dizziness, dizzy, married woman's eclamposia, total numbness.
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is the dried root of Ranunculaceae aconitum plant aconitum brachypodum (Aconitum brachypodum Diels), Radix aconiti szechenyiani (Aconitumszechenyianum Gay), Aconitum nagarum var.lasiandrum W.T.Wang (Aconitum nagarum Stapf var.lasianduum W.T.Wang).Property suffering, temperature, bitter in the mouth, very toxic.Contain multiple alkaloid, as aconitine, hypaconitine, bullatine etc.Function cures mainly: anti-inflammatory analgetic, expelling wind and removing dampness.Be used for traumatic injury, rheumatic ostalgia, toothache, fracture, sprain, sore swollen toxin etc.
Second purpose of the present invention is achieved through the following technical solutions: the external preparation method of Chinese medicine that a kind of treatment is sprained is characterized in that through following each processing step:
A, get material by following mass percent:
Caulis Sargentodoxae 10-40%
Herba Hedyotidis Diffusae 8-30%
Herba Lycopi 8-30%
Herba pratiae begonifoliae 8-30%
Radix Boehmeriae 5-20%
Herba speranskiae tuberculatae 5-20%
Ramulus Uncariae Cum Uncis 5-20%
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2-10%
B, respectively above-mentioned medical material directly is broken into medicated powder, perhaps through decoction, dipping, backflow, diafiltration, ultrasonic Treatment, the CO of all kinds of solvents
2Critical (subcritical) extraction adds proper quantity of medicinal auxiliary material again to extract the effective ingredient in the medical material, and utilization conventional formulation method is prepared into the external used medicine that the treatment of dosage forms such as tincture, ointment, aerosol, membrane, cataplasma, rubber-emplastrum is sprained.
The preferred following extraction processing method of the present invention:
(1) adds 4-15 times of water Herba Hedyotidis Diffusae, Herba Lycopi, Radix Boehmeriae, Herba speranskiae tuberculatae were decocted 1-4 hour, filter; Filtering residue adds 4-15 times of decocting again and boiled 1-4 hour, filters merging filtrate; Filtrate is condensed into extractum, adds concentration and be 95% alcoholic solution and make and contain the alcohol amount and reach 60-90%; Standing over night extracts supernatant; The supernatant decompression recycling ethanol, it is standby to get extractum.
(2) in Caulis Sargentodoxae, Herba pratiae begonifoliae, Ramulus Uncariae Cum Uncis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), add the 60-90% alcoholic solution that 3-10 doubly measures,, filter in 60-80 ℃ of hot reflux 1-4 hour; The 60-90% alcoholic solution that filtering residue reuse 3-10 doubly measures extracted 1-4 hour in 60-80 ℃ of hot reflux, filtered merging filtrate; Decompression filtrate recycling ethanol, it is standby to get extractum;
(3),, be prepared into tincture with the dilution of 50-95% dissolve with ethanol solution with step (1), (2) gained extractum mix homogeneously; Perhaps
(4) step (1), (2) gained extractum are mixed, and be heated to 60-100 ℃, other gets the ointment base heating and melting, slowly joins in the hot dipping cream, and stirring is prepared into ointment; Perhaps
(5) step (1), (2) gained extractum are merged, again with suitable hydrophilic matrix mix homogeneously after, coat to mount on the backing material and make cataplasma; Perhaps
(6) step (1), (2) gained extractum are mixed, make rubber-emplastrum on the backing material with coating to mount after substrate such as rubber, tackifier, softening agent, filler are mixed; Perhaps
(7) step (1), (2) gained extractum are mixed, be diluted to suitable concentration, be sub-packed in the container after the adding adjuvant prepares medicinal liquid, mounted valve is tightened sealing cap, fills propellant and makes aerosol; Perhaps
(8) step (1), (2) gained extractum are mixed, join in the filmogen solution, mixed film had both got membrane.
The external Chinese medicine that treatment provided by the invention is sprained, select for use have promoting flow of QI and blood, the Chinese crude drug reasonable formula of eliminating blood stasis and smoothing collaterals, reducing swelling and alleviating pain effect, play the ecchymosis that disappears, eliminate pain, alleviate swelling and the active effect of restore funcitons, determined curative effect, effect are good.Can be prepared into exterior-applied formulations such as tincture, ointment, aerosol, membrane, cataplasma, rubber-emplastrum as required, preparation method is scientific and reasonable, and effective ingredient runs off few, the bioavailability height, and equipment needed thereby is simple, and is with short production cycle, pollution-free.The present invention is as external preparation, has efficient, low toxicity, safety, advantage easily.
The specific embodiment
Embodiment 1
A, get material: Caulis Sargentodoxae 20g, Herba Hedyotidis Diffusae 15g, Herba Lycopi 15g, Herba pratiae begonifoliae 15g, Radix Boehmeriae 10g, Herba speranskiae tuberculatae 10g, Ramulus Uncariae Cum Uncis 10g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5g by following prescription.
B, the following preparation technology of process:
(1) adds 8 times of water Herba Hedyotidis Diffusae, Herba Lycopi, Radix Boehmeriae, Herba speranskiae tuberculatae were decocted 3 hours, filter; Filtering residue adds 6 times of decoctings again and boiled 2 hours, filters merging filtrate; Filtrate is condensed into extractum, adds concentration and be 95% alcoholic solution and make and contain the alcohol amount and reach 75%; Standing over night extracts supernatant; The supernatant decompression recycling ethanol, it is standby to get extractum.
(2) 75% alcoholic solution of 5 times of amounts of adding in Caulis Sargentodoxae, Herba pratiae begonifoliae, Ramulus Uncariae Cum Uncis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) in 80 ℃ of hot refluxs 1.5 hours, filters; 75% alcoholic solution of 5 times of amounts of filtering residue reuse extracted 1 hour in 80 ℃ of hot refluxs, filtered merging filtrate; Decompression filtrate recycling ethanol, it is standby to get extractum;
(3) step (1), (2) gained extractum are mixed,, be prepared into tincture with 80% alcoholic solution 50ml dissolved dilution.
Embodiment 2
A, get material: Caulis Sargentodoxae 100g, Herba Hedyotidis Diffusae 200g, Herba Lycopi 200g, Herba pratiae begonifoliae 200g, Radix Boehmeriae 80g, Herba speranskiae tuberculatae 80g, Ramulus Uncariae Cum Uncis 80g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30g by following prescription.
B, the following preparation technology of process:
(1) adds 10 times of water Herba Hedyotidis Diffusae, Herba Lycopi, Radix Boehmeriae, Herba speranskiae tuberculatae were decocted 2 hours, filter; Filtering residue adds 8 times of decoctings again and boiled 2 hours, filters merging filtrate; Filtrate is condensed into extractum, adds concentration and be 95% alcoholic solution and make and contain the alcohol amount and reach 70%; Standing over night extracts supernatant; The supernatant decompression recycling ethanol, it is standby to get extractum.
(2) 70% alcoholic solution of 6 times of amounts of adding in Caulis Sargentodoxae, Herba pratiae begonifoliae, Ramulus Uncariae Cum Uncis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) in 75 ℃ of hot refluxs 2 hours, filters; 70% alcoholic solution of 5 times of amounts of filtering residue reuse extracted 1.5 hours in 75 ℃ of hot refluxs, filtered merging filtrate; Decompression filtrate recycling ethanol, it is standby to get extractum;
(3) get sodium polyacrylate 14g, polyvinyl alcohol 12g, sodium carboxymethyl cellulose 7g, gelatin 35g, Tween 80 g adds an amount of swelling of water, again Kaolin 4g, glycerol 78g, Oleum Ricini 5g is added the back mix homogeneously, makes semisolid matrix.Step (1), (2) gained extractum are mixed, add in the substrate, stir, be coated with cream lid lining, section is prepared into cataplasma.
Embodiment 3
A, get material: Caulis Sargentodoxae 30g, Herba Hedyotidis Diffusae 10g, Herba Lycopi 10g, Herba pratiae begonifoliae 10g, Radix Boehmeriae 10g, Herba speranskiae tuberculatae 10g, Ramulus Uncariae Cum Uncis 10g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 8g by following prescription
B, the following preparation technology of process:
(1) adds 12 times of water Herba Hedyotidis Diffusae, Herba Lycopi, Radix Boehmeriae, Herba speranskiae tuberculatae were decocted 3 hours, filter; Filtering residue adds 12 times of decoctings again and boiled 3 hours, filters merging filtrate; Filtrate is condensed into extractum, adds concentration and be 95% alcoholic solution and make and contain the alcohol amount and reach 80%; Standing over night extracts supernatant; The supernatant decompression recycling ethanol, it is standby to get extractum.
(2) 80% alcoholic solution of 8 times of amounts of adding in Caulis Sargentodoxae, Herba pratiae begonifoliae, Ramulus Uncariae Cum Uncis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) in 70 ℃ of hot refluxs 2 hours, filters; 80% alcoholic solution of 8 times of amounts of filtering residue reuse extracted 2 hours in 70 ℃ of hot refluxs, filtered merging filtrate; Decompression filtrate recycling ethanol, it is standby to get extractum;
(3) step (1), (2) gained extractum are mixed, and be heated to 85 ℃, other gets about ointment base vaseline 5g, liquid paraffin 1g Hybrid Heating to 80 ℃ and makes fusion, slowly joins in the hot dipping cream, and stirring is prepared into ointment.
Therapeutic effect
Case is included standard in: the patient amounts to 31 people, and damage location sees waist, ankle, shoulder, neck, breast, side of body rib, sacrum tail, knee joint etc. and locates, and has tangible local swelling and pain, skin that ecchymosis or subcutaneous hemorrhage, dysfunction are arranged.
Therapeutic Method: according to the embodiment of the invention 1 preparation tincture, divide to be applied in the affected part 3 times, change dressings every day 1 time, 10 is 1 course of treatment.
Criterion of therapeutical effect: 1. cure: treatment back functional rehabilitation normally or normal substantially, affected part pain disappears.2. take a turn for the better: affected part pain obviously alleviates, and function is obviously recovered.3. invalid: symptom and sign does not have improvement or increases the weight of.
Therapeutic outcome: medication was cured 23 examples after 10 days, 8 examples that take a turn for the better, cure rate 74.2%, improvement rate 25.8%, total effective rate 100%.
Model case:
Zhao, the male, 34 years old, to sprain accidentally because of lifting weight, the readme flank pain is violent, and the waist activity is seriously limited.Look into lumbosacral region depth tenderness and be all the positive, anteflexion, after stretch, rotate all limited, the deep breathing pain is obvious, the pick-up test positive.According to the embodiment of the invention 1 preparation tincture, divide to be applied in the affected part 3 times, change dressings every day 1 time, suitably be aided with massage, cooperate the waistline protection.Patient's readme has not had obvious pain after 3 days, feels uncomfortable when bending over slightly, and the patient is not different from after 10 days.
Guo, the male 15 years old, sprains left ankle joint accidentally and caused pain and swelling 1 day when playing soccer.Inspection is seen: left legs and feet limitation of activity, and left ankle swelling, local skin temperature is higher.According to the embodiment of the invention 1 preparation tincture, divide 3 external applications, drug of topical application area is changed dressings 1 time than the big 1cm of damaged area every day, and is fixing with the wrapping of the capable ankle joint of elastic bandage " 8 " word, the degree of tightness appropriateness.And advise the patient to take in sail, raise and suffer from the limb rest.Swelling did not increase the weight of when changed dressings next day, pain relief; Swelling in the 3rd day begins to disappear, and pain disappears; Swelling in the 5th day is eliminated substantially, and walking obviously flexibly.The patient is not different from after 10 days.
Claims (4)
1. external Chinese medicine that treatment is sprained is characterized in that being made up of following raw materials by weight percentage:
Caulis Sargentodoxae 10-40%
Herba Hedyotidis Diffusae 8-30%
Herba Lycopi 8-30%
Herba pratiae begonifoliae 8-30%
Radix Boehmeriae 5-20%
Herba speranskiae tuberculatae 5-20%
Ramulus Uncariae Cum Uncis 5-20%
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2-10%.
2. the external Chinese medicine that treatment according to claim 1 is sprained is characterized in that the external Chinese medicine that described treatment is sprained, preferred following raw materials by weight percentage combination, and curative effect is better:
Caulis Sargentodoxae 20%
Herba Hedyotidis Diffusae 15%
The Herba Lycopi 15%
Herba pratiae begonifoliae 15%
Radix Boehmeriae 10%
Herba speranskiae tuberculatae 10%
Ramulus Uncariae Cum Uncis 10%
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5%.
3. the external preparation method of Chinese medicine that treatment according to claim 1 is sprained is characterized in that through following method preparation:
A, get material by following mass percent:
Caulis Sargentodoxae 10-40%
Herba Hedyotidis Diffusae 8-30%
Herba Lycopi 8-30%
Herba pratiae begonifoliae 8-30%
Radix Boehmeriae 5-20%
Herba speranskiae tuberculatae 5-20%
Ramulus Uncariae Cum Uncis 5-20%
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2-10%;
B, respectively above-mentioned medical material directly is broken into medicated powder, perhaps through decoction, dipping, backflow, diafiltration, ultrasonic Treatment, the CO of all kinds of solvents
2Critical (subcritical) extraction adds proper quantity of medicinal auxiliary material again to extract the effective ingredient in the medical material, and utilization conventional formulation method is prepared into the external used medicine that the treatment of dosage forms such as tincture, ointment, aerosol, membrane, cataplasma, rubber-emplastrum is sprained.
4. the external preparation method of Chinese medicine that treatment according to claim 3 is sprained is characterized in that preferred following extraction processing method:
(1) adds 4-15 times of water Herba Hedyotidis Diffusae, Herba Lycopi, Radix Boehmeriae, Herba speranskiae tuberculatae were decocted 1-4 hour, filter; Filtering residue adds 4-15 times of decocting again and boiled 1-4 hour, filters merging filtrate; Filtrate is condensed into extractum, adds concentration and be 95% alcoholic solution and make and contain the alcohol amount and reach 60-90%; Standing over night extracts supernatant; The supernatant decompression recycling ethanol, it is standby to get extractum.
(2) in Caulis Sargentodoxae, Herba pratiae begonifoliae, Ramulus Uncariae Cum Uncis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), add the 60-90% alcoholic solution that 3-10 doubly measures,, filter in 60-80 ℃ of hot reflux 1-4 hour; The 60-90% alcoholic solution that filtering residue reuse 3-10 doubly measures extracted 1-4 hour in 60-80 ℃ of hot reflux, filtered merging filtrate; Decompression filtrate recycling ethanol, it is standby to get extractum;
(3),, be prepared into tincture with the dilution of 50-95% dissolve with ethanol solution with step (1), (2) gained extractum mix homogeneously; Perhaps
(4) step (1), (2) gained extractum are mixed, and be heated to 60-100 ℃, other gets the ointment base heating and melting, slowly joins in the hot dipping cream, and stirring is prepared into ointment; Perhaps
(5) step (1), (2) gained extractum are merged, again with suitable hydrophilic matrix mix homogeneously after, coat to mount on the backing material and make cataplasma; Perhaps
(6) step (1), (2) gained extractum are mixed, make rubber-emplastrum on the backing material with coating to mount after substrate such as rubber, tackifier, softening agent, filler are mixed; Perhaps
(7) step (1), (2) gained extractum are mixed, be diluted to suitable concentration, be sub-packed in the container after the adding adjuvant prepares medicinal liquid, mounted valve is tightened sealing cap, fills propellant and makes aerosol; Perhaps
(8) step (1), (2) gained extractum are mixed, join in the filmogen solution, mixed film had both got membrane.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8991478B2 (en) | 2010-03-29 | 2015-03-31 | Hamilton Sundstrand Space Systems International, Inc. | Compact two sided cold plate with transfer tubes |
| CN105664227A (en) * | 2016-01-25 | 2016-06-15 | 邱定武 | Bandage for treating cut injuries and preparation method thereof |
| CN105749196A (en) * | 2014-12-14 | 2016-07-13 | 粟若潇 | Chinese herbal medicine preparation for treating lumbar disc herniation and multifunctional high-efficiency application apparatus thereof |
| CN115738371A (en) * | 2022-12-05 | 2023-03-07 | 山东柳新堂健康产业有限公司 | Subcritical double-solvent extraction method and application thereof |
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| CN1195529A (en) * | 1997-04-07 | 1998-10-14 | 谢朝云 | Drug for curing traumatic injuries and its preparing method |
| CN1342479A (en) * | 2001-04-27 | 2002-04-03 | 包培祯 | Quick-acting oral liquid for treating sprain and pull and its preparing process |
| CN1876034A (en) * | 2006-04-19 | 2006-12-13 | 云南雄业制药有限公司 | An externally applied analgetic and preparation method thereof |
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2010
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195529A (en) * | 1997-04-07 | 1998-10-14 | 谢朝云 | Drug for curing traumatic injuries and its preparing method |
| CN1342479A (en) * | 2001-04-27 | 2002-04-03 | 包培祯 | Quick-acting oral liquid for treating sprain and pull and its preparing process |
| CN1876034A (en) * | 2006-04-19 | 2006-12-13 | 云南雄业制药有限公司 | An externally applied analgetic and preparation method thereof |
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| 《中国民间疗法》 20030131 李贵等 家传膏药二方 27 1-4 第11卷, 第1期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8991478B2 (en) | 2010-03-29 | 2015-03-31 | Hamilton Sundstrand Space Systems International, Inc. | Compact two sided cold plate with transfer tubes |
| CN105749196A (en) * | 2014-12-14 | 2016-07-13 | 粟若潇 | Chinese herbal medicine preparation for treating lumbar disc herniation and multifunctional high-efficiency application apparatus thereof |
| CN105664227A (en) * | 2016-01-25 | 2016-06-15 | 邱定武 | Bandage for treating cut injuries and preparation method thereof |
| CN115738371A (en) * | 2022-12-05 | 2023-03-07 | 山东柳新堂健康产业有限公司 | Subcritical double-solvent extraction method and application thereof |
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| CN102008576B (en) | 2012-05-30 |
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