CN108392555A - Bedsore emplastrum - Google Patents

Abstract

Bedsore emplastrum is using Chinese herbal medicines such as Radix Angelicae Sinensis, Radix Glycyrrhizae, the root of Dahurain angelica, semen armeniacae amarae and rosemary through processing as a kind of emplastrum of main ingredient (and dissolve in hyaluronic acid etc.).It can not only treat bedsore, it may also be used for treat other various scytitis, ulcer sores, activate blood circulation and disperse blood clots, swelling and pain relieving, skin itchy and mange etc..But also pigmentation, freckle, blackspot can be eliminated etc., and there is the effect of skin whitening.

Description

Bedsore emplastrum

The present invention relates to a kind of emplastrums, more particularly to a kind of bedsore emplastrum.

Bedsore refers generally to pressure sore, is being commonly called as pressure sore.Pressure sore, that is, pressure ulcer is the hair because local organization is pressurized for a long time Raw duration ischemic, anoxic, malnutrition and cause tissue fester downright bad.Pressure ulcer is a kind of general in rehabilitation, nursing The problem of all over property.It is a kind of common skin diseases caused by pressure factor, nutrition condition, skin resistance reduction etc.. Pressure sore early stage rubefaction should then take the measures such as turn decompression that can improve.Fester when superficial occurs in skin, ulcer, exudation It when liquid is more, should just be treated in time, such as drug therapy, physical therapy, Chinese medicine external therapy or even surgical operation.Paralysis disease People's long-term bed if nursing is improper is easy for that bedsore occurs, be mostly because of long sleeping and less replacement position, skin in compression and Caused by ischemic；Especially underfed patient and paralyzed limbs are easier that bedsore occurs with sensory disturbance person.Bedsore is once Occur, not only results in nursing difficulty, and influence the rehabilitation of patient, severe patient goes back entail dangers to life.Bedsore occurs often in The apophysis position of compression.Sore face is disinfected frequently with bedsore powder, band bed sore ointment and hydrogen peroxide or medicinal alcohol at present in treatment, is used In treatment slough, dead skin.These medicinal powder, ointment are not easy to be easy to make bedding etc. by medicinal powder, medicine in apophysis position adherency, treatment Cream pollutes, and use is not very convenient.So it is various may result in delay treatment and aggravation.On the other hand, emplastrum mean by Drug is dissolved or is mixed in natural or synthetic high molecular material matrix, and booth is coated in framed back material, for sticking one kind of skin Exterior-applied formulation.Emplastrum is a kind of important percutaneous dosing mode, refer to extract, medicine materical crude slice and chemicals and suitable matrix and The manufactured external preparation for being sticked for skin, a kind of sheet topically or systemically acted on being generated of base material.It includes rubber paste Agent, gel ointment (also referred to as Babu plaster) and patch etc..This specification is related to three kinds of emplastrums as above.Currently, China's emplastrum It is used primarily in antalgic and inflammation relieving field, common physical distress includes neck shoulder lumbago；Acute and chronic strain is pulled and osteoarthritis Deng.External used medicine can directly act on affected part, efficient and simple and convenient, can avoid oral analgesic common gastrointestinal tract and liver Kidney side effect.From the point of view of product, common emplastrum has SHEXIANG ZHUANGGU GAO, shangshi zhitong plaster, shangshi zhitong gao, analgesic rheumatoid plaster, removing dampness and relieving pain Cream, activating meridians to stop pain cream, analgesic plaster and Yunnan Baiyao cream etc., these emplastrums belong to anodyne without exception.At present still Without the emplastrum for treating bedsore.The bedsore emplastrum of this patent is mainly used for treating skin disease.Because medicinal material used in it is to work as Return, Radix Glycyrrhizae, the root of Dahurain angelica, semen armeniacae amarae, frankincense, calomel mercurous chloride, myrrh, Chinese herbal medicines or its extract such as dragon's blood and rosemary, therefore it is not only With anti-corrosive antibacterial effect, and can also be used to treat a kind of various dermopathic emplastrums such as bedsore.

It is an object of the present invention to create a kind of bedsore emplastrum, make the skin of people convenient for directly absorb Radix Angelicae Sinensis, Radix Glycyrrhizae, The active ingredient of the root of Dahurain angelica, semen armeniacae amarae and rosemary etc., for treating bedsore, also act as treat other various scytitis, Ulcer sores activate blood circulation and disperse blood clots, swelling and pain relieving, skin itchy and mange etc..

In order to achieve the above objectives, bedsore emplastrum of the invention, be by the Radix Angelicae Sinensis through processing, Radix Glycyrrhizae, the root of Dahurain angelica, semen armeniacae amarae with And a kind of emplastrum of the Chinese herbal medicines such as rosemary as main ingredient (and dissolving in hyaluronic acid (NMF)).To further enhance emplastrum Drug effect, the Chinese herbal medicines such as Radix Angelicae Sinensis, Radix Glycyrrhizae, the root of Dahurain angelica, semen armeniacae amarae, frankincense, calomel mercurous chloride, myrrh, dragon's blood and rosemary through processing are made For main ingredient, a kind of bedsore spray may also be fabricated which.

So-called emplastrum means material medicine and suitable matrix paste is made, is coated on back lining materials for skin Skin sticks, and can generate a kind of systemic or local action laminar preparation.Emplastrum is a kind of modern Percutaneously administrable preparation, closely Develop very fast over year, have the characteristics that all of transdermal drug delivery system, i.e., first pass effect without liver avoids gastrointestinal tract from destroying, is malicious Small side effects, lasting medicine, easy to use etc..As previously mentioned, emplastrum includes gel ointment, rubber ointment etc..Gel ointment Original is known as Babu plaster (abbreviation cataplasm), after meaning extract, medicine materical crude slice or chemicals and suitable hydrophilic matrix mixing, It is coated on manufactured emplastrum on back lining materials.And rubber ointment refers to extract or the matrix mixing such as chemicals and rubber Afterwards, it is coated on back lining materials and manufactured emplastrum.The structure of gel ointment includes three parts：1. back sheet, mainly as The carrier of lotion commonly uses non-woven fabrics or spun rayon cloth etc.；2. paste layer, i.e. matrix and main ingredient part, generate one in sticking Fixed adhesion is allowed to be in close contact with skin, to achieve the purpose that treatment；3. anti-stick layer.Play a part of to protect lotion, usually Use anti-sticker, plastic film and hard gauze etc..The gel ointment is characterized in, the good biocompatibility of a. and skin, Hydrophilic macromolecule matrix has gas permeability, absorption of perspiration, without sensitization and nonirritant；B. drugloading rate is big, is particularly suitable for The medicinal extract of Chinese medicine；C. Release Performance is good, strong with the compatibility of skin, can improve the hydration of cuticula, it is saturating to be conducive to drug Skin absorbs；D. Transdermal absorption controlled-release technology is applied to make blood concentration held stationary, lasting medicine；E. easy to use, it will not pollute Clothing or bedding, it is washable to remove, it can paste repeatedly；F. gasoline and other organic solvents are not used in production process, are avoided to ring The pollution in border.And rubber ointment, it can directly be affixed on skin.It does not pollute skin, clothing or bedding, matrix chemical inertness.The former The shortcomings that be the barrier action that need to overcome skin, it is desirable that it is with certain adhesive force and skin permeation rate.And the latter's layer of paste is relatively thin, carries Dose is smaller, holds time shorter, and irritant, anaphylaxis, it is easy to aging the shortcomings of.On the other hand, scientific research proves, when Return, Radix Glycyrrhizae, the root of Dahurain angelica etc. have different degrees of antibacterial antisepsis.Radix Angelicae Sinensis has antibacterial anti-corrosion and anti-inflammatory effect；For another example Radix Glycyrrhizae, Sodium benzoate therein is the anti-corrosion composition in the drug, it has certain bacteriostasis；And the root of Dahurain angelica is to Escherichia coli, dysentery Bacillus, proteus, typhoid bacillus, paratyphosum Bacterium, Pseudomonas aeruginosa, comma bacillus, Bacillus tuberculosis etc. have inhibition to make With；And Rosmarinus officinalis extract is to Escherichia coli, bacillus subtilis, Bacillus cercus, salmonella, Staphylococcus aureus 7 kinds of bacterium, proteus, micrococcus luteus bacteriums have bacteriostatic activity.(《Food industry science and technology》,2011,32(7):67-70). Rosemary has very strong anti-corrosive antibacterial to act on, and has stronger inhibition killing effect to Escherichia coli, comma bacillus etc..So-called cotton-padded mattress Sore emplastrum, in addition to antibacterial antisepsis, wherein Radix Angelicae Sinensis cures mainly ulcer sores, traumatic injury, for activating blood circulation and dispersing blood clots, subsiding a swelling Analgesic；And licorice tablet, it is a kind of kobadrin drug, effect is rather extensive.Extract of licorice root and preparation after refining and processing are It is a kind of with good cough-relieving, eliminating the phlegm, antiasthmatic effect drug.Radix Glycyrrhizae then has good white-skinned face function for skin.Radix Glycyrrhizae Effect be far above in this, Chinese medicine think Radix Glycyrrhizae have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription work( Effect, is " state is old " in Chinese medicine, is one of most common Chinese medicinal material, and most of Traditional Chinese medicinal prescription has all been arranged in pairs or groups Radix Glycyrrhizae, i.e., so-called " ten sides, nine grass ".Why Chinese medicine thinks that Radix Glycyrrhizae has these effects, is because Radix Glycyrrhizae is sweet in flavor, according to yin-yang and five elements theory, sweet category Soil, soil is placed in the middle, so Radix Glycyrrhizae energy " middle benefit gas ", Chinese medicine thinks that all poison are met soil and changed, and Radix Glycyrrhizae is " essences of nine soil ", so Radix Glycyrrhizae can solve All poison (《Bencao Jingshu》《Compendium of Materia Medica》).As for the root of Dahurain angelica, it is used as medicine with root, the dehumidifying that gets rid of illness, apocenosis myogenic, promoting blood circulation and stopping pain Etc. multiple functions.The root of Dahurain angelica cures mainly pain furuncle poison, can also control knife arrow and hinder sore etc..In addition, semen armeniacae amarae has anti-inflammatory and analgesic effect.It is modern Research has shown that fat oil contained in semen armeniacae amarae can be such that keratoderma softens, and moisturize skin care, have the neural peripheral vessel of protection and Histoorgan and the effect that bactericidal can be pressed down.In addition, internal active tyrosine can be inhibited by the HCN that enzyme hydrolysis is generated Enzyme eliminates pigmentation, freckle, blackspot etc., to achieve the effect that beautifying skin.And frankincense, traumatic injury, carbuncle swells sore can be controlled Ulcer.Calomel mercurous chloride, take orally have eliminating the phlegm disperse accumulation, relieve oedema or abdominal distension through diuresis or purgation defaecation the effect of.It is outer to control for scabies, stubborn dermatitis, ulcer on the shank, syphilis, sore and wet Rash.In addition to traditional Chinese medicine ingredients, hyaluronic acid is shown with its unique molecular structure and physicochemical property in body a variety of important Physiological function, such as lubricating joint adjust the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, promote wound Healing etc..Particular, it is important that hyaluronic acid has special water retention, it is that moisture retention is best in presently found nature Substance, being referred to as ideal natural moisturizing factor (Natural moisturizing factor, NMF), it can improve skin Skin Nutrition and Metabolism, make skin it is tender, it is smooth, go wrinkle, increase elasticity, prevent aging, be good transdermal again while moisturizing Sorbefacient.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.To sum up, The bedsore emplastrum of this patent exactly utilizes the Chinese herbal medicines such as Radix Angelicae Sinensis, Radix Glycyrrhizae, the root of Dahurain angelica, semen armeniacae amarae, frankincense, calomel mercurous chloride and rosemary Antiseptic and inhibiting bacteria function acts on, and creates a kind of emplastrum for treating bedsore.It is demonstrated experimentally that when treating bedsore, bedsore emplastrum is not by people The position of body limits, and only apply can make bedsore be almost recovered in 1 week or so.Not only in this way, bedsore emplastrum can treat it is various Inflammatory pain, ulcer sores, activate blood circulation and disperse blood clots, skin itchy, mange and traumatic injury, knife arrow hinder the various diseases such as sore.And this Emplastrum can also eliminate pigmentation, freckle, blackspot etc., and have the effect of skin whitening.

Claims (2)

1. a kind of emplastrum, which is characterized in that comprising a Radix Angelicae Sinensis through processing, Radix Glycyrrhizae, the root of Dahurain angelica, semen armeniacae amarae, frankincense, calomel mercurous chloride, The Chinese herbal medicine powders such as myrrh, dragon's blood and rosemary or its extract are as main ingredient (and dissolve in hyaluronic acid etc.)；One by these Chinese herbal medicine or its extract are coated on back lining materials and manufactured bedsore emplastrum.

2. emplastrum according to claim 1, it is characterized in that by Radix Angelicae Sinensis, Radix Glycyrrhizae, the root of Dahurain angelica, semen armeniacae amarae, breast through processing The Chinese herbal medicines such as perfume, calomel mercurous chloride, myrrh, dragon's blood and rosemary are made into a kind of cotton-padded mattress as main ingredient (and dissolve in hyaluronic acid etc.) Sore spray.