CN108420980A - It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof - Google Patents

It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof Download PDF

Info

Publication number
CN108420980A
CN108420980A CN201810535869.4A CN201810535869A CN108420980A CN 108420980 A CN108420980 A CN 108420980A CN 201810535869 A CN201810535869 A CN 201810535869A CN 108420980 A CN108420980 A CN 108420980A
Authority
CN
China
Prior art keywords
parts
skin injury
bacterium infection
oil
antibacterial ointment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201810535869.4A
Other languages
Chinese (zh)
Inventor
郑和国
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wuhan Runhe Biological Medical Co Ltd
Original Assignee
Wuhan Runhe Biological Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuhan Runhe Biological Medical Co Ltd filed Critical Wuhan Runhe Biological Medical Co Ltd
Priority to CN201810535869.4A priority Critical patent/CN108420980A/en
Publication of CN108420980A publication Critical patent/CN108420980A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to it is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof, belong to treatment skin injury, bacterium infection technical field of pharmaceuticals, the parts by weight of its each component are 5 ~ 8 parts of Asian puccoon, callicarpa nudiflora 5 ~ 8 parts, 4 ~ 7 parts of kuh-seng, 4 ~ 7 parts of monkshood, 3 ~ 5 parts of the tuber of stemona, 3 ~ 5 parts of giant knotweed, 3 ~ 5 parts of Radix Notoginseng, 3 ~ 5 parts of frankincense, 2 ~ 5 parts of myrrh, 3 ~ 6 parts of Sculellaria barbata, 3 ~ 5 parts of chlorohexidene, 20 ~ 40 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate；The present invention is to be based on modern Chinese medicine with doctor trained in Western medicine to skin injury, the pathogenetic understanding of bacterium infection and principle of reatment, and selected Chinese and western medical raw material is formulated using unique formula；The antibacterial ointment antibacterial anti-inflammatory is antipruritic, and clinical efficacy is notable, has no toxic side effect.

Description

It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof
Technical field
The present invention relates to a kind of ointment and preparation method thereof, and in particular to a kind of suppression for treating skin injury, bacterium infection Bacterium ointment and preparation method thereof belongs to treatment skin injury, bacterium infection technical field of pharmaceuticals.
Background technology
Skin infection can be divided into bacillary, fungoid and viral.When there is red, swollen, pain, purulence, mostly skin bacterium Sexuality dye.Skin infection may alternatively appear in Various Seasonal, and hair crowd is extensive well, has more the portions such as present face, neck, chest, the back of the body, shoulder, hand, foot Position.Common skin bacterial infected with：Impetigo（It is commonly called as " impetigo "）Epifolliculitis, furuncle, carbuncle, skin injury infection, eczema, Prickly heat secondary bacterial infection.Tinea pedis secondary bacterial infection, acne secondary bacterial infection.Bacterial skin infections will appear when serious Situations such as shiver with cold, fever, hospital should be arrived in time this moment and be treated.
There are many antibacterial anti-inflammatory ointment of class for the existing common external used medicine of skin infection treatment, but toxicity is stronger mostly, And it is ineffective；Therefore, the present invention propose it is a kind of treat skin injury, bacterium infection antibacterial ointment, it is easy to use, and due to Traditional Chinese medicine ingredients are used, are free from side effects, uneasy to recur, curative effect is satisfactory.
Invention content
The present invention is and to propose a kind of antibacterial in order to solve the problems, such as to treat the treatment of skin injury, bacterium infection at present, disappear Scorching antipruritic good effect, treatment skin injury without side-effects, bacterium infection antibacterial ointment.The antibacterial ointment mainly will be various Chinese medicine material is ground into powder, then heating melts, emulsifies uniform and manufactured together with grease, emulsifier and thickener, conveniently makes With and smear.
To achieve the above object, the present invention adopts the following technical scheme that：
It is a kind of treat skin injury, bacterium infection antibacterial ointment, the parts by weight of each component are：
5 ~ 8 parts of Asian puccoon, callicarpa nudiflora 5 ~ 8 parts, 4 ~ 7 parts of kuh-seng, 4 ~ 7 parts of monkshood, 3 ~ 5 parts of the tuber of stemona, 3 ~ 5 parts of giant knotweed, Radix Notoginseng 3 ~ 5 Part, 3 ~ 5 parts of frankincense, 2 ~ 5 parts of myrrh, 3 ~ 6 parts of Sculellaria barbata, 3 ~ 5 parts of chlorohexidene, 20 ~ 40 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate；
5 ~ 6 parts of Asian puccoon, callicarpa nudiflora 5 ~ 6 parts, 6 ~ 7 parts of kuh-seng, 6 ~ 7 parts of monkshood, 4 ~ 5 parts of the tuber of stemona, 4 ~ 5 parts of giant knotweed, Radix Notoginseng 4 ~ 5 Part, 4 ~ 5 parts of frankincense, 4 ~ 5 parts of myrrh, 4 ~ 6 parts of Sculellaria barbata, 4 ~ 5 parts of chlorohexidene, 20 ~ 40 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate；
7 ~ 8 parts of Asian puccoon, callicarpa nudiflora 7 ~ 8 parts, 4 ~ 5 parts of kuh-seng, 4 ~ 5 parts of monkshood, 3 ~ 4 parts of the tuber of stemona, 3 ~ 4 parts of giant knotweed, Radix Notoginseng 3 ~ 4 Part, 3 ~ 4 parts of frankincense, 2 ~ 4 parts of myrrh, 3 ~ 4 parts of Sculellaria barbata, 3 ~ 4 parts of chlorohexidene, 20 ~ 40 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
It is a kind of treat skin injury, bacterium infection antibacterial ointment preparation method, including following preparation process：
（1）It crushes：By Asian puccoon, callicarpa nudiflora, kuh-seng, monkshood, the tuber of stemona, giant knotweed, Radix Notoginseng, frankincense, myrrh, Sculellaria barbata, chlorohexidene Equal Chinese medicine materials are ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering； The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
The pharmacological property of Chinese medicine used in the present invention is as follows：
Asian puccoon：Cool blood, promoting blood circulation, heat-clearing, removing toxic substances；
It is callicarpa nudiflora：Anti-inflammatory is detoxified, and is restrained, hemostasis；
Kuh-seng：Heat-clearing and damp-drying drug, desinsection is antipruritic, antibacterial, anti-inflammatory, antiallergy；
Monkshood：Dispelling wind and eliminating dampness, antalgic；
The tuber of stemona：Moistening lung to lower qi cough-relieving, desinsection；
Giant knotweed：Clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, scattered stasis pain is relieving cough and reducing sputum；
Radix Notoginseng：Dissipate stasis of blood hemostasis, detumescence ding-tong；
Sculellaria barbata：It is clearing heat and detoxicating, promoting blood circulation, swelling and pain relieving；
Frankincense：It activates blood and relax tendons, promoting qi circulation and relieving pain；
Myrrh：The promoting flow of qi and blood circulation, swelling and pain relieving；
Castor oil：Bitter, cool in nature, purging intense heat, except steaming, detoxification sore treatment；
Chlorohexidene：A kind of wide-spectrum bactericide, it can be combined with saliva glycoprotein, and facing adhesion protein is made to reduce, and interfere bacterial plaque shape At.In addition, chlorohexidene can also be combined with bacterial cell exo polysaccharides, makes bacterium be not easy to be adsorbed onto on acquisition film, reach prevention and subtract The purpose of few periodontosis and dental caries.
Chlorhexidine acetate：Also it is Robenidine Roripa, chlorhexidine acetate, Chlorhexidine, double benzyl chloride chlorhexidine, for sun Ionic surface active agent, has a broad antifungal spectrum have killing effect to most Grain-positives and negative bacteria, also have to Pseudomonas aeruginosa Effect, for remote holder of performing the operation, skin, planing surface and sterilization of instruments.
The invention has the advantages that and advantageous effect：
The present invention is the pathogenetic understanding and principle of reatment with doctor trained in Western medicine to skin injury, bacterium infection based on modern Chinese medicine, Selected Chinese and western medical raw material, is formulated using unique formula；When treatment, this appropriate reagent is taken to be applied to affected part, one day one Secondary or twice, a month as a course for the treatment of；It takes effect within usual one month, can cure within 1~5 month；The antibacterial ointment is not easy multiple after curing Hair, has no toxic side effect.
Specific implementation mode
Product of the present invention is further described below in conjunction with the embodiment of the present invention, the description of embodiment is only for ease of understanding With with the application of the invention, rather than to the limitation protected of the present invention.Unless stated otherwise, preparation process under room temperature, normal pressure state into Row；Unless stated otherwise, the reagent that is used in the present invention, method and apparatus is the art conventional reagent, method and apparatus； Unless stated otherwise, the experimental condition used in the present invention is the art normal test conditions；Unless stated otherwise, this hair Bright middle agents useful for same is purchased in market.
Embodiment 1
It is a kind of treat skin injury, bacterium infection antibacterial ointment, the parts by weight of each component are：
5 parts of Asian puccoon, callicarpa nudiflora 5 parts, 7 parts of kuh-seng, 7 parts of monkshood, 5 parts of the tuber of stemona, 5 parts of giant knotweed, 5 parts of Radix Notoginseng, 5 parts of frankincense, myrrh 5 Part, 6 parts of Sculellaria barbata, 5 parts of chlorohexidene, 35 parts of castor oil, 4 parts of acetic acid chlorhexidine, 2 parts of lauryl sodium sulfate, vitamin E oil 4 Part, 2 parts of glycerin monostearate；
It is a kind of treat skin injury, bacterium infection antibacterial ointment preparation method, including following preparation process：
（1）It crushes：By Asian puccoon, callicarpa nudiflora, kuh-seng, monkshood, the tuber of stemona, giant knotweed, Radix Notoginseng, frankincense, myrrh, Sculellaria barbata, chlorohexidene Equal Chinese medicine materials are ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering； The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
Embodiment 2
It is a kind of treat skin injury, bacterium infection antibacterial ointment, the parts by weight of each component are：
6 parts of Asian puccoon, callicarpa nudiflora 6 parts, 5 parts of kuh-seng, 5 parts of monkshood, 4 parts of the tuber of stemona, 4 parts of giant knotweed, 4 parts of Radix Notoginseng, 4 parts of frankincense, myrrh 4 Part, 4 parts of Sculellaria barbata, 4 parts of chlorohexidene, 35 parts of castor oil, 4 parts of acetic acid chlorhexidine, 2 parts of lauryl sodium sulfate, vitamin E oil 4 Part, 2 parts of glycerin monostearate；
It is a kind of treat skin injury, bacterium infection antibacterial ointment preparation method, including following preparation process：
（1）It crushes：By Asian puccoon, callicarpa nudiflora, kuh-seng, monkshood, the tuber of stemona, giant knotweed, Radix Notoginseng, frankincense, myrrh, Sculellaria barbata, chlorohexidene Equal Chinese medicine materials are ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering； The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
Embodiment 3
It is a kind of treat skin injury, bacterium infection antibacterial ointment, the parts by weight of each component are：
8 parts of Asian puccoon, callicarpa nudiflora 8 parts, 4 parts of kuh-seng, 4 parts of monkshood, 3 parts of the tuber of stemona, 3 parts of giant knotweed, 3 parts of Radix Notoginseng, 3 parts of frankincense, myrrh 2 Part, 3 parts of Sculellaria barbata, 3 parts of chlorohexidene, 35 parts of castor oil, 4 parts of acetic acid chlorhexidine, 2 parts of lauryl sodium sulfate, vitamin E oil 4 Part, 2 parts of glycerin monostearate；
It is a kind of treat skin injury, bacterium infection antibacterial ointment preparation method, including following preparation process：
（1）It crushes：By Asian puccoon, callicarpa nudiflora, kuh-seng, monkshood, the tuber of stemona, giant knotweed, Radix Notoginseng, frankincense, myrrh, Sculellaria barbata, chlorohexidene Equal Chinese medicine materials are ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering； The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
Clinical trial is reported：
One, clinical manifestation：
(1) psoriasis：Itch, maculopapule, scaling erythema, koebner levy the big warts of grain grain and asymmetry periphery joint It is scorching.
(2) neurodermatitis：Itch, papule, mossization have dry skin without exudation, are apt to occur in the neck portion easily to be rubbed, Elbow joint stretches side, the positions such as base fabric.
(3) eczema：Papule, papulo-vesicle have sepage, and incrustation, normal symmetry distribution, chronic eczema has rough coat, moss Change or have and is chapped from the cold.
(4) nettle rash：Normal unexpected onset, first feels pruitus, occurs differing in size quickly, form differs, cerise Or pale asphyxia wheal.Being dispersed in distribution can also merge in flakes.It dissipates and leaves no trace after several minutes or a few hours, but new wheal is again successively Occur.Some patients can have respiratory tract and symptom of digestive tract.
(5) acne：This disease is apt to occur in youth of both sexes, is apt to occur in facial area, papule of the fash based on acne, tubercle, capsule The pleomorphism damage such as swollen is characterized.
Two, curative effect determinate standard
Clinical cure：Symptom all disappears after treatment, restores completely at skin lesion, skin smooth is identical as normal skin.
Effectively：Symptom is substantially reduced, and skin lesion area reduces, and the state of an illness is controlled.
In vain：Symptom is without change.
Three, clinical application method and treatment results
1, clinical application method
Control group patient does not smear external used medicine and treats；
Experimental group patient smears the medicament in embodiment 1-3, and massage 3~5 minutes after cleaning affected part half an hour with clear water, 3 times a day, seven days as a treatment course.2 courses for the treatment of are used continuously.
2. therapeutic effect：
Table one：Therapeutic effect
Recovery from illness It is effective Effectively In vain It is total
Treatment group 20 14 3 4 41
Control group 6 10 11 14 41
It can be seen that from one data of table：
One, treatment group：Cure rate 48.8%；Obvious effective rate is 34.1%；Effective percentage is 7.3%；Inefficiency is 9.8%.
Two, control group：Cure rate 14.6%；Obvious effective rate is 24.4%；Effective percentage is 26.9%；Inefficiency is 34.1%.
The above is only the application implementation mode of the present invention, it is noted that for the ordinary skill people of the art For member, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvements and modifications Also it should be regarded as protection scope of the present invention.

Claims (4)

1. it is a kind of treat skin injury, bacterium infection antibacterial ointment, which is characterized in that the parts by weight of each component are：
5 ~ 8 parts of Asian puccoon, callicarpa nudiflora 5 ~ 8 parts, 4 ~ 7 parts of kuh-seng, 4 ~ 7 parts of monkshood, 3 ~ 5 parts of the tuber of stemona, 3 ~ 5 parts of giant knotweed, Radix Notoginseng 3 ~ 5 Part, 3 ~ 5 parts of frankincense, 2 ~ 5 parts of myrrh, 3 ~ 6 parts of Sculellaria barbata, 3 ~ 5 parts of chlorohexidene, 20 ~ 40 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
2. it is a kind of treat skin injury, bacterium infection antibacterial ointment, which is characterized in that the parts by weight of each component are：
5 ~ 6 parts of Asian puccoon, callicarpa nudiflora 5 ~ 6 parts, 6 ~ 7 parts of kuh-seng, 6 ~ 7 parts of monkshood, 4 ~ 5 parts of the tuber of stemona, 4 ~ 5 parts of giant knotweed, Radix Notoginseng 4 ~ 5 Part, 4 ~ 5 parts of frankincense, 4 ~ 5 parts of myrrh, 4 ~ 6 parts of Sculellaria barbata, 4 ~ 5 parts of chlorohexidene, 20 ~ 40 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
3. it is a kind of treat skin injury, bacterium infection antibacterial ointment, which is characterized in that the parts by weight of each component are：
7 ~ 8 parts of Asian puccoon, callicarpa nudiflora 7 ~ 8 parts, 4 ~ 5 parts of kuh-seng, 4 ~ 5 parts of monkshood, 3 ~ 4 parts of the tuber of stemona, 3 ~ 4 parts of giant knotweed, Radix Notoginseng 3 ~ 4 Part, 3 ~ 4 parts of frankincense, 2 ~ 4 parts of myrrh, 3 ~ 4 parts of Sculellaria barbata, 3 ~ 4 parts of chlorohexidene, 20 ~ 40 parts of castor oil, 2 ~ 5 parts of acetic acid chlorhexidine, 1 ~ 2 part of lauryl sodium sulfate, 2 ~ 5 parts of vitamin E oil, 1 ~ 3 part of glycerin monostearate.
4. it is a kind of treat skin injury, bacterium infection antibacterial ointment preparation method, which is characterized in that including following preparation walk Suddenly：
（1）It crushes：By Asian puccoon, callicarpa nudiflora, kuh-seng, monkshood, the tuber of stemona, giant knotweed, Radix Notoginseng, frankincense, myrrh, Sculellaria barbata, chlorohexidene Equal Chinese medicine materials are ground into fine powder with pulverizer；
（2）Decoction filtering：The purified water of 20 times of amounts of raw material gross weight is added in fine powder, decocts 2 ~ 3h, filtrate is collected in filtering； The water that 8 ~ 15 times of amounts of medicinal material weight are added in the dregs of a decoction again decocts 1 ~ 2h, and filtrate is collected in filtering, filtrate will merge twice；
（3）Concentration：The heating of above-mentioned filtrate is concentrated into the medicinal extract of semisolid；
（4）Drying and crushing：It by medicinal extract freeze-drying at solid, crushes, crosses 200 mesh sieve, obtain Chinese medicinal powder；
（5）Melt emulsification：It takes castor oil and acetic acid chlorhexidine to be heated in 70~80 DEG C of water-baths, melts, stir evenly, then Lauryl sodium sulfate, vitamin E oil and glycerin monostearate is added, heating fusing stirs evenly, obtains emulsion；
（6）Mixing：Chinese medicinal powder is added in above-mentioned emulsion, stirs evenly and cools down to get the antibacterial ointment.
CN201810535869.4A 2018-05-30 2018-05-30 It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof Withdrawn CN108420980A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810535869.4A CN108420980A (en) 2018-05-30 2018-05-30 It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810535869.4A CN108420980A (en) 2018-05-30 2018-05-30 It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof

Publications (1)

Publication Number Publication Date
CN108420980A true CN108420980A (en) 2018-08-21

Family

ID=63164503

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810535869.4A Withdrawn CN108420980A (en) 2018-05-30 2018-05-30 It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof

Country Status (1)

Country Link
CN (1) CN108420980A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116726066A (en) * 2023-07-27 2023-09-12 中科万康药业(广州)有限公司 Sustained-release antibacterial gel composition and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101879283A (en) * 2010-06-13 2010-11-10 中国人民解放军第三军医大学 Novel membrane spraying preparation for skin trauma and preparation method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101879283A (en) * 2010-06-13 2010-11-10 中国人民解放军第三军医大学 Novel membrane spraying preparation for skin trauma and preparation method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
《药学服务指南丛书》编委会: "《非处方药使用手册》", 30 April 2005, 群言出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116726066A (en) * 2023-07-27 2023-09-12 中科万康药业(广州)有限公司 Sustained-release antibacterial gel composition and preparation method thereof
CN116726066B (en) * 2023-07-27 2024-03-26 中科万康药业(广州)有限公司 Antibacterial gel composition and preparation method thereof

Similar Documents

Publication Publication Date Title
US11571452B2 (en) Method of treating a skin wound with a liquid-state topical pharmaceutical composition
CN108578615A (en) A kind of antibacterial ointment preparation method for treating pruritus dermatopathy
CN110292602A (en) Yellow burn oil formula of a kind of compound five and preparation method thereof
CN104415265A (en) Ointment for treating onychomycosis and preparation method thereof
CN1326546C (en) Pure Chinese medicinal preparation for external treating burn and scald
CN113398237B (en) Traditional Chinese medicine composition with antibacterial, itching relieving and dandruff stopping functions and preparation method thereof
CN106474350A (en) A kind of plant antibiotic compound spray and preparation method thereof
CN110664858B (en) Artemisia annua extract composition for skin, product and application thereof
CN105168361A (en) Compound plant oil liniment for treating burns and scalds and preparation method of compound plant oil liniment
CN108420980A (en) It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof
CN102698086B (en) Chinese medicinal emulsion for treating bedsore accumulated toxin decay
CN101904932B (en) External application Chinese ointment for preventing and curing skin injury caused by ionizing radiation
CN107007761A (en) A kind of Chinese medicine burn oil and preparation method thereof
CN105055661A (en) Composition for treating scalds and preparation method thereof
CN101940652B (en) Chinese medicinal liniment for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus
CN106728069B (en) Slough-removing and tissue regeneration-promoting paste for treating scalds and burns
CN116585404B (en) External traditional Chinese medicine composition for treating adult simple skin pruritus and preparation method thereof
CN104306734B (en) Treat diabetic gangrene externally applied ointment preparation and preparation method thereof
CN116570700B (en) Traditional Chinese medicine preparation with antibacterial, anti-inflammatory and acne removing effects and application thereof
CN107233406A (en) A kind of traditional Chinese medicine for outer use for treating hormone face
CN107714781B (en) Pharmaceutical composition for treating burns and scalds and preparation method and application thereof
CN107096017A (en) Treat dermopathic external medicine composition and its application method
CN104906217A (en) Traditional Chinese medicine ointment for treating acute catarrhal conjunctivitis and preparation method thereof
CN113082079A (en) External medicinal liquor for hyperosteogeny
CN103356777B (en) Medicament for treating rosacea

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20180821

WW01 Invention patent application withdrawn after publication