CN116726066B - Antibacterial gel composition and preparation method thereof - Google Patents
Antibacterial gel composition and preparation method thereof Download PDFInfo
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- CN116726066B CN116726066B CN202310928946.3A CN202310928946A CN116726066B CN 116726066 B CN116726066 B CN 116726066B CN 202310928946 A CN202310928946 A CN 202310928946A CN 116726066 B CN116726066 B CN 116726066B
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- gel composition
- antibacterial
- quaternary ammonium
- ammonium salt
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 76
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 239000000284 extract Substances 0.000 claims abstract description 50
- -1 polysiloxane Polymers 0.000 claims abstract description 44
- 238000000855 fermentation Methods 0.000 claims abstract description 38
- 230000004151 fermentation Effects 0.000 claims abstract description 38
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 36
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 33
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 29
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 244000086363 Pterocarpus indicus Species 0.000 claims abstract description 15
- 235000009984 Pterocarpus indicus Nutrition 0.000 claims abstract description 15
- 239000002023 wood Substances 0.000 claims abstract description 14
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims abstract description 11
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims abstract description 11
- 229940075000 frankincense extract Drugs 0.000 claims abstract description 11
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 10
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 22
- 239000000306 component Substances 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 20
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 12
- 125000004122 cyclic group Chemical group 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- NKSJNEHGWDZZQF-UHFFFAOYSA-N ethenyl(trimethoxy)silane Chemical compound CO[Si](OC)(OC)C=C NKSJNEHGWDZZQF-UHFFFAOYSA-N 0.000 claims description 9
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 8
- 229920002554 vinyl polymer Polymers 0.000 claims description 8
- WZJUBBHODHNQPW-UHFFFAOYSA-N 2,4,6,8-tetramethyl-1,3,5,7,2$l^{3},4$l^{3},6$l^{3},8$l^{3}-tetraoxatetrasilocane Chemical compound C[Si]1O[Si](C)O[Si](C)O[Si](C)O1 WZJUBBHODHNQPW-UHFFFAOYSA-N 0.000 claims description 7
- 244000131316 Panax pseudoginseng Species 0.000 claims description 6
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 6
- 235000019270 ammonium chloride Nutrition 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- PZJJKWKADRNWSW-UHFFFAOYSA-N trimethoxysilicon Chemical compound CO[Si](OC)OC PZJJKWKADRNWSW-UHFFFAOYSA-N 0.000 claims description 6
- 244000063299 Bacillus subtilis Species 0.000 claims description 5
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 5
- 241000717739 Boswellia sacra Species 0.000 claims description 5
- 239000004863 Frankincense Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 239000001888 Peptone Substances 0.000 claims description 5
- 108010080698 Peptones Proteins 0.000 claims description 5
- 241000235342 Saccharomycetes Species 0.000 claims description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
- 229940041514 candida albicans extract Drugs 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 5
- FWDBOZPQNFPOLF-UHFFFAOYSA-N ethenyl(triethoxy)silane Chemical compound CCO[Si](OCC)(OCC)C=C FWDBOZPQNFPOLF-UHFFFAOYSA-N 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 239000001963 growth medium Substances 0.000 claims description 5
- 239000012046 mixed solvent Substances 0.000 claims description 5
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 5
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 235000019319 peptone Nutrition 0.000 claims description 5
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 5
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 239000012138 yeast extract Substances 0.000 claims description 5
- 238000005086 pumping Methods 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 229910000077 silane Inorganic materials 0.000 claims description 3
- 239000003377 acid catalyst Substances 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 7
- 230000007794 irritation Effects 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 description 19
- 241000894006 Bacteria Species 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- 239000002253 acid Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 206010015150 Erythema Diseases 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 231100000321 erythema Toxicity 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- TZZGHGKTHXIOMN-UHFFFAOYSA-N 3-trimethoxysilyl-n-(3-trimethoxysilylpropyl)propan-1-amine Chemical compound CO[Si](OC)(OC)CCCNCCC[Si](OC)(OC)OC TZZGHGKTHXIOMN-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010033733 Papule Diseases 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 229920002413 Polyhexanide Polymers 0.000 description 2
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- 238000005325 percolation Methods 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- WSFMFXQNYPNYGG-UHFFFAOYSA-M dimethyl-octadecyl-(3-trimethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OC)(OC)OC WSFMFXQNYPNYGG-UHFFFAOYSA-M 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229940031575 hydroxyethyl urea Drugs 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of antibacterial compositions, and discloses a slow-release antibacterial gel composition and a preparation method thereof. The slow-release antibacterial gel composition comprises the following components in percentage by mass: 0.18 to 0.22 percent of chlorhexidine gluconate; 6-15% of ethanol; 0.2 to 0.5 percent of notoginseng fermentation extract; 0.3 to 0.8 percent of rosewood heart wood extract; 0.5 to 1 percent of frankincense extract; 0.5 to 1 percent of polysiloxane quaternary ammonium salt; cyclodextrin 1-5%; the balance of water. The antibacterial gel composition adopts polysiloxane quaternary ammonium salt and notoginseng fermentation extract, rosewood heart wood extract and frankincense extract and chlorhexidine gluconate as antibacterial components, and has the advantages of high antibacterial activity, stable antibacterial activity, small irritation and mild formula.
Description
Technical Field
The invention belongs to the technical field of antibacterial compositions, and particularly relates to a slow-release antibacterial gel composition and a preparation method thereof.
Background
Disposable sanitary articles are various daily necessities which are discarded after being used once, are in direct or indirect contact with human bodies, and are used for achieving the purposes of human physiological sanitation or health care antibacterial or bacteriostatic, and the antibacterial gel is a disposable sanitary article widely used by people in daily life.
As patent CN 111467249A, a no-clean antibacterial gel is disclosed, which consists of polyhexamethylene biguanide hydrochloride, dichlorobenzyl alcohol, sodium hyaluronate gel, glycerin, propylene glycol, hypromellose, polyether, hydroxyethyl urea and purified water. The bactericide is formed by compounding dichlorobenzyl alcohol and polyhexamethylene biguanide hydrochloride, so that the sterilizing effect is effectively improved. Patent CN 109432201A discloses a gynecological antibacterial gel, which is prepared from poloxamer, electrolytic silver ion antibacterial agent and glycerin, wherein the silver ion concentration of the electrolytic silver ion antibacterial agent is controlled to be matched with the poloxamer and the glycerin within a proper content range, so that a pasty gel which has a slow release effect and can adapt the phase change temperature to the temperature of a human body and stay in the vagina for a long time is formed, and meanwhile, the antibacterial performance can be well exerted. In addition, after the electrolytic silver ion antibacterial agent, the chamomile extract and the rose extract are compounded, the antibacterial and bactericidal effects are better, the adhesive performance of the pasty gel on the inner wall of the vagina can be maintained, and the long-time drug effect is maintained. Patent CN 107028875A discloses a polyamino acid antibacterial gel, which comprises the following components in percentage by weight: 0.01-50% of polyamino acid, 0.01-90% of gel matrix, 0-20% of humectant, 0-1% of preservative and the balance of water. The polyamino acid gel combines the advantages of both polyamino acid materials and gel, and has good antibacterial property and biocompatibility.
However, the antibacterial composition generally has the problems of complex antibacterial components or narrow application range, so that the development of the antibacterial gel composition with mild components, good antibacterial effect and strong compatibility adaptability and the preparation method thereof have remarkable market value.
Disclosure of Invention
In view of the above drawbacks and deficiencies of the prior art, a primary object of the present invention is to provide a slow-release antimicrobial gel composition.
Another object of the present invention is to provide a method for preparing the above sustained-release antibacterial gel composition.
The invention aims at realizing the following technical scheme:
a slow-release antibacterial gel composition comprises the following components in percentage by mass:
preferably, the slow-release antibacterial gel composition comprises the following components in percentage by mass:
further, the notoginseng fermentation extract is prepared by the following method:
adding the pseudo-ginseng powder into water, sterilizing at 105-120 ℃ for 15-30 min, cooling, inoculating zymophyte bacterial liquid, fermenting and culturing at 35-40 ℃ for 24-120 h, centrifuging after sterilizing at high temperature, collecting supernatant and concentrating to obtain the pseudo-ginseng fermentation extract.
The preparation method of the notoginseng fermentation extract has the advantages of high extraction rate and high product activity.
Further preferably, the fermentation broth is a mixed fermentation broth containing bacillus subtilis and saccharomycetes.
Further preferably, the zymophyte bacterial liquid adopts glucose with the mass concentration of 1.5-2.5%, peptone with the mass concentration of 0.5-1%, yeast extract with the mass concentration of 0.5-1%, monopotassium phosphate with the mass concentration of 0.02-0.1% and calcium carbonate with the mass concentration of 0.02-0.1% as culture medium components.
Further, the polysiloxane quaternary ammonium salt refers to a polysiloxane quaternary ammonium salt with a ring structure, and the polysiloxane quaternary ammonium salt is prepared by the following method:
adding tetramethyl cyclotetrasiloxane (D4H) and vinyl-containing alkoxy silane compound into ethanol solvent, adding chloroplatinic acid catalyst, stirring and mixing uniformly, heating to 75-80 ℃ under nitrogen protection for reaction, adding dimethyl octadecyl [3- (trimethoxy silicon-based) propyl ] ammonium chloride (DC-5700), stirring and dissolving uniformly, dripping water for coupling reaction, and vacuum pumping out solvent and low-boiling substances to obtain polysiloxane quaternary ammonium salt with a cyclic structure.
The invention adopts polysiloxane quaternary ammonium salt with specific cyclic structure and chlorhexidine gluconate as main antibacterial components, and has the advantages of high antibacterial activity, small irritation and strong compatibility adaptability. Meanwhile, the polysiloxane quaternary ammonium salt with the cyclic structure has good compatibility in a system, and the surface activity of the polysiloxane quaternary ammonium salt is combined with cyclodextrin to wrap the notoginseng fermentation extract, the rosewood heart wood extract and the frankincense extract, so that a certain slow release effect is achieved, and the system stability is improved.
Further preferably, the vinyl-containing alkoxysilane compound includes at least one of vinyltrimethoxysilane and vinyltriethoxysilane; the addition amount of the vinyl-containing alkoxysilane compound is 3-4 times of the molar amount of the tetramethyl cyclotetrasiloxane.
Further preferably, the addition amount of the dimethyloctadecyl [3- (trimethoxysilyl) propyl ] ammonium chloride is 1 to 3 times the molar amount of the vinyl-containing alkoxysilane compound.
The preparation method of the slow-release antibacterial gel composition comprises the following preparation steps:
adding chlorhexidine gluconate into a mixed solvent of water and ethanol for dissolving uniformly, heating to 50-80 ℃, adding cyclodextrin and polysiloxane quaternary ammonium salt, stirring for dissolving uniformly, cooling to below 60 ℃, sequentially adding the notoginseng fermentation extract, the rosewood heart wood extract and the frankincense extract, stirring for mixing uniformly, and standing for more than 24 hours to obtain the slow-release antibacterial gel composition.
Compared with the prior art, the invention has the beneficial effects that:
(1) The antibacterial gel composition adopts chlorhexidine gluconate and polysiloxane quaternary ammonium salt with a specific cyclic structure as main antibacterial components, and has the advantages of high antibacterial activity, small irritation and strong compatibility adaptability.
(2) The antibacterial gel composition disclosed by the invention can wrap the pseudo-ginseng fermentation extract, the rosewood heart wood extract and the frankincense extract by utilizing the surface activity of the polysiloxane quaternary ammonium salt with a cyclic structure and the cyclodextrin, so that a certain slow release effect is achieved, and the system stability is improved.
(3) The invention further adopts the notoginseng fermentation extract, the rosewood heart wood extract and the frankincense extract as the active ingredients with the functions of resisting bacteria and resisting inflammation, and has the advantages of stable antibacterial activity and mild formula.
(4) The existing extraction process of the total saponins of panax notoginseng mainly comprises a water decoction and alcohol precipitation method, an ethanol reflux method and a percolation method. Wherein the water decoction and alcohol precipitation method is easy to gelatinize because the notoginseng contains a large amount of starch and polysaccharide in the water decoction process; after alcohol precipitation, the saponin loss is large due to the adsorption effect of precipitation, the extraction rate is low, the content of the product components is not stable, and the method is widely used for developing food; the percolation method has higher extraction rate, simple operation and less impurity in the extracting solution, but excessive solvent consumption, and is mainly used for medicines; the ethanol reflux method is simple and convenient, the process condition is easy to control, but the extraction rate is lower. Compared with the existing method, the preparation method of the notoginseng fermentation extract has the advantages of high extraction rate and high product activity.
Detailed Description
The present invention will be described in further detail with reference to examples, but embodiments of the present invention are not limited thereto.
Example 1
The slow-release antibacterial gel composition comprises the following components in percentage by mass:
the notoginseng fermentation extract is prepared by the following method:
adding notoginseng powder with the mass fraction of 8% into water, sterilizing at the high temperature of 110 ℃ for 20min, cooling, and inoculating fermentation bacteria liquid, wherein the fermentation bacteria liquid is mixed fermentation bacteria liquid containing bacillus subtilis and saccharomycetes. The fermentation bacteria liquid adopts glucose with the mass concentration of 2 percent, peptone with the mass concentration of 0.8 percent, yeast extract with the mass concentration of 0.6 percent, monopotassium phosphate with the mass concentration of 0.03 percent and calcium carbonate with the mass concentration of 0.02 percent as culture medium components. Then fermenting and culturing for 48h under the condition of a shaking table at the temperature of 35-40 ℃, sterilizing at the high temperature of 110 ℃, centrifuging, taking supernatant, and concentrating to obtain the notoginseng fermentation extract.
The polysiloxane quaternary ammonium salt refers to a polysiloxane quaternary ammonium salt with a ring structure, and is prepared by the following method:
adding tetramethyl cyclotetrasiloxane (D4H) and vinyl trimethoxy silane into an ethanol solvent, wherein the molar ratio of the D4H to the vinyl trimethoxy silane is 1:4, then adding a catalytic amount of chloroplatinic acid isopropanol solution, stirring and mixing uniformly, heating to 75-80 ℃ under the protection of nitrogen, stirring and reacting for 4 hours, adding dimethyl octadecyl [3- (trimethoxy silicon) propyl ] ammonium chloride (DC-5700), stirring and dissolving uniformly, adding a proper amount of water (the theoretical amount of all hydrolysis of the vinyl trimethoxy silane and the DC-5700) in a dropwise manner, and carrying out coupling reaction to obtain the polysiloxane quaternary ammonium salt with a cyclic structure.
The preparation method of the slow-release antibacterial gel composition comprises the following preparation steps:
adding chlorhexidine gluconate into a mixed solvent of water and ethanol for dissolving uniformly, heating to 70-75 ℃, adding cyclodextrin and polysiloxane quaternary ammonium salt, stirring for dissolving uniformly, cooling to below 60 ℃, sequentially adding the notoginseng fermentation extract, the rosewood heart wood extract and the frankincense extract, stirring for mixing uniformly, and standing for more than 24 hours to obtain the slow-release antibacterial gel composition.
Example 2
The slow-release antibacterial gel composition comprises the following components in percentage by mass:
the notoginseng fermentation extract is prepared by the following method:
adding 10% of pseudo-ginseng powder into water according to the mass fraction, sterilizing at 105 ℃ for 30min, cooling, and inoculating fermentation bacteria liquid, wherein the fermentation bacteria liquid is mixed fermentation bacteria liquid containing bacillus subtilis and saccharomycetes. The fermentation bacteria liquid adopts glucose with the mass concentration of 1.5%, 1% peptone, 1% yeast extract, 0.05% monopotassium phosphate and 0.05% calcium carbonate as culture medium components. Then fermenting and culturing for 72h under the condition of a shaking table at the temperature of 35-40 ℃, sterilizing at the high temperature of 105 ℃, centrifuging, taking supernatant, and concentrating to obtain the notoginseng fermentation extract.
The polysiloxane quaternary ammonium salt refers to a polysiloxane quaternary ammonium salt with a ring structure, and is prepared by the following method:
adding tetramethyl cyclotetrasiloxane (D4H) and vinyl triethoxysilane into an ethanol solvent, wherein the molar ratio of the D4H to the vinyl triethoxysilane is 1:3, then adding a catalytic amount of chloroplatinic acid isopropanol solution, stirring and mixing uniformly, heating to 75-80 ℃ under the protection of nitrogen, stirring and reacting for 3 hours, adding dimethyl octadecyl [3- (trimethoxy silicon) propyl ] ammonium chloride (DC-5700), stirring and dissolving uniformly after the reaction is finished, dropwise adding a proper amount of water (the theoretical amount of vinyl triethoxysilane and all hydrolysis of DC-5700) for coupling reaction, and vacuum pumping the solvent and low-boiling-point substances to obtain the polysiloxane quaternary ammonium salt with the annular structure.
The preparation method of the slow-release antibacterial gel composition comprises the following preparation steps:
adding chlorhexidine gluconate into a mixed solvent of water and ethanol for dissolving uniformly, heating to 60-65 ℃, adding cyclodextrin and polysiloxane quaternary ammonium salt, stirring for dissolving uniformly, cooling to below 60 ℃, sequentially adding the notoginseng fermentation extract, the rosewood heart wood extract and the frankincense extract, stirring for mixing uniformly, and standing for more than 24 hours to obtain the slow-release antibacterial gel composition.
Example 3
The slow-release antibacterial gel composition comprises the following components in percentage by mass:
the notoginseng fermentation extract is prepared by the following method:
adding 6% of notoginseng powder into water according to the mass fraction, sterilizing at 115 ℃ for 15min, cooling, and inoculating fermentation bacteria liquid, wherein the fermentation bacteria liquid is mixed fermentation bacteria liquid containing bacillus subtilis and saccharomycetes. The fermentation bacteria liquid adopts glucose with the mass concentration of 2.5 percent, peptone with the mass concentration of 0.5 percent, yeast extract with the mass concentration of 0.5 percent, monopotassium phosphate with the mass concentration of 0.02 percent and calcium carbonate with the mass concentration of 0.02 percent as culture medium components. Then fermenting and culturing for 36h under the condition of a shaking table at the temperature of 35-40 ℃, sterilizing at the high temperature of 115 ℃, centrifuging, taking supernatant, and concentrating to obtain the notoginseng fermentation extract.
The polysiloxane quaternary ammonium salt refers to a polysiloxane quaternary ammonium salt with a ring structure, and is prepared by the following method:
adding tetramethyl cyclotetrasiloxane (D4H) and vinyl trimethoxy silane into an ethanol solvent, wherein the molar ratio of the D4H to the vinyl trimethoxy silane is 1:3.5, then adding a catalytic amount of chloroplatinic acid isopropanol solution, stirring and mixing uniformly, heating to 75-80 ℃ under the protection of nitrogen, stirring and reacting for 3.5H, adding dimethyl octadecyl [3- (trimethoxy silicon) propyl ] ammonium chloride (DC-5700), stirring and dissolving uniformly after the reaction is finished, adding an amount of DC-5700 which is 2 times the molar amount of the vinyl trimethoxy silane, dropwise adding a proper amount of water (the theoretical amount of the vinyl trimethoxy silane and the total hydrolysis of the DC-5700), performing coupling reaction, and vacuum pumping the solvent and low-boiling substances to obtain the polysiloxane quaternary ammonium salt with a cyclic structure.
The preparation method of the slow-release antibacterial gel composition comprises the following preparation steps:
adding chlorhexidine gluconate into a mixed solvent of water and ethanol for dissolving uniformly, heating to 75-80 ℃, adding cyclodextrin and polysiloxane quaternary ammonium salt, stirring for dissolving uniformly, cooling to below 60 ℃, sequentially adding the notoginseng fermentation extract, the rosewood heart wood extract and the frankincense extract, stirring for mixing uniformly, and standing for more than 24 hours to obtain the slow-release antibacterial gel composition.
1. The antibacterial gel composition obtained in the above example was subjected to antibacterial performance test, and was tested with reference to appendix C4 of GB 15979-2002 hygienic Standard for Disposable sanitary products, the test strain being Escherichia coli; the sample is used for primary action for 2min, 5min, 10min and 20min, the test is repeated for 3 times to obtain an average value, and the test temperature is 23 ℃. The test results are shown in table 1 below.
TABLE 1 antibacterial Property test results
As can be seen from the results in Table 1, the antibacterial gel composition provided by the invention has the antibacterial rate of more than 95% on Escherichia coli after being acted for 2min, 5min, 10min and 20min, and has a strong antibacterial effect.
2. The antibacterial gel composition obtained in the above example was subjected to a mildness test, and the gel composition was applied to the skin, covered with a patch, and after 24 hours, the test article was removed and the skin reaction was observed, as described in appendix A3 of GB 15979-2002 "Disposable sanitary articles sanitary Standard". The grading scale is as follows: no significant response compared to the blank was grade 0; weak erythema was grade 1; erythema reaction (erythema, infiltration, edema, possibly papule) was grade 2; the occurrence of herpes response (erythema, infiltration, edema, papule, herpes; response can exceed the test area) was grade 3; the appearance of the fusional herpes response (apparent erythema, severe infiltration, edema, fusional herpes; response beyond the test zone) was grade 4. The test results are shown in table 2 below.
Table 2 mildness test results
| Test sample | Example 1 | Example 2 | Example 3 |
| Mild grade | Level 0 | Level 0 | Level 0 |
As can be seen from the results in Table 2, the antibacterial gel composition obtained by the invention has small irritation and mild formulation.
3. The antibacterial gel composition obtained in the above example was subjected to stability test, and the gel morphology was observed and the antibacterial rate (10 min) was tested by using an acceleration test in a incubator at 54 to 57 ℃ for 14 days, with reference to annex C6 of GB 15979-2002 hygienic Standard for disposable sanitary products, and the results are shown in Table 3 below.
TABLE 3 stability test results
| Test sample | Example 1 | Example 2 | Example 3 |
| Gel morphology | Liquid without sediment and obvious flowing | Liquid without sediment and obvious flowing | Liquid without sediment and obvious flowing |
| Antibacterial rate | 99.67％ | 99.08％ | 99.25％ |
As can be seen from the results in Table 3, the antibacterial gel composition obtained by the invention has excellent high temperature resistance stability and antibacterial stability.
Comparative example 1
In this comparative example, the Notoginseng radix fermented extract, the lignum Dalbergiae Odoriferae extract and the Olibanum extract were not added, and the mass percentage of the remaining effective components was unchanged, compared with example 1.
Comparative example 2
In this comparative example, the mass percent of the remaining effective components was unchanged from example 1 without the addition of a silicone quaternary ammonium salt.
Comparative example 3
Compared with the example 1, the comparative example adopts equivalent DC-5700 antibacterial agent to replace polysiloxane quaternary ammonium salt, and the mass percentage of the rest effective matters is unchanged.
4. The antibacterial property test was conducted on the antibacterial gel composition obtained in the above comparative example, and the results are shown in table 4 below.
TABLE 4 antibacterial Property test results
As can be seen from the results in Table 4, the Notoginseng radix fermented extract, the rosewood heart wood extract and the olibanum extract, and the polysiloxane quaternary ammonium salt in the antibacterial gel composition of the present invention have obvious synergistic effect on the improvement of antibacterial properties.
5. The antibacterial gel composition obtained in the above comparative example was subjected to a mildness test, and the results are shown in table 5 below.
TABLE 5 mildness test results
| Test sample | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Mild grade | Level 1 | Level 1 | Level 1 |
As can be seen from the results of Table 5, the Notoginseng radix fermented extract, the rosewood extract and the olibanum extract, and the polysiloxane quaternary ammonium salt with a specific cyclic structure in the antibacterial gel composition of the present invention can reduce the irritation of the antibacterial gel composition of the present invention, and the polysiloxane quaternary ammonium salt with a specific cyclic structure has better mildness than the DC-5700 antibacterial agent.
6. The antibacterial gel composition obtained in the above comparative example was subjected to stability test, and the results are shown in table 6 below.
TABLE 6 stability test results
As can be seen from the results in Table 6, the Notoginseng radix fermented extract, the rosewood heart wood extract and the olibanum extract have an improvement effect on the antibacterial stability of the antibacterial gel composition of the present invention, and the polysiloxane quaternary ammonium salt with a specific cyclic structure has an obvious improvement effect on the gel form stability and antibacterial stability of the antibacterial gel composition.
The above examples are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above examples, and any other changes, modifications, substitutions, combinations, and simplifications that do not depart from the spirit and principle of the present invention should be made in the equivalent manner, and the embodiments are included in the protection scope of the present invention.
Claims (4)
1. An antibacterial gel composition is characterized by comprising the following components in percentage by mass:
0.18% -0.22% of chlorhexidine gluconate;
6% -15% of ethanol;
0.2% -0.5% of notoginseng fermentation extract;
0.3-0.8% of rosewood heart wood extract;
0.5% -1% of frankincense extract;
0.5% -1% of polysiloxane quaternary ammonium salt;
cyclodextrin 1% -5%;
the balance of water;
the notoginseng fermentation extract is prepared by the following method:
adding the pseudo-ginseng powder into water, sterilizing at a high temperature of 105-120 ℃ for 15-30 min, cooling, inoculating zymophyte bacterial liquid, fermenting and culturing at a temperature of 35-40 ℃ for 24-120 h, centrifuging after sterilizing at a high temperature, and concentrating the supernatant to obtain a pseudo-ginseng fermentation extract;
the zymophyte liquid is mixed zymophyte liquid containing bacillus subtilis and saccharomycetes;
the polysiloxane quaternary ammonium salt refers to a polysiloxane quaternary ammonium salt with a ring structure, and is prepared by the following method:
adding tetramethyl cyclotetrasiloxane and vinyl-containing alkoxy silane compound into ethanol solvent, adding chloroplatinic acid catalyst, stirring and mixing uniformly, heating to 75-80 ℃ under nitrogen protection for reaction, adding dimethyl octadecyl [3- (trimethoxy silicon base) propyl ] ammonium chloride after the reaction is completed, stirring and dissolving uniformly, dripping water for coupling reaction, and vacuum pumping out solvent and low-boiling substances to obtain polysiloxane quaternary ammonium salt with a cyclic structure;
the vinyl-containing alkoxysilane compound includes at least one of vinyltrimethoxysilane and vinyltriethoxysilane; the addition amount of the vinyl-containing alkoxy silane compound is 3-4 times of the molar amount of the tetramethyl cyclotetrasiloxane; the addition amount of the dimethyl octadecyl [3- (trimethoxy silicon based) propyl ] ammonium chloride is 1-3 times of the molar amount of the vinyl-containing alkoxysilane compound.
2. An antimicrobial gel composition according to claim 1, wherein the antimicrobial gel composition comprises the following components in percentage by mass:
chlorhexidine gluconate 0.2%;
ethanol 10%;
0.3% of notoginseng fermented extract;
0.5% of rosewood heart wood extract;
0.7% of olibanum extract;
0.8% of polysiloxane quaternary ammonium salt;
cyclodextrin 3%;
84.5% of water.
3. The antibacterial gel composition according to claim 1, wherein the fermentation broth adopts glucose with a mass concentration of 1.5% -2.5%, peptone with a mass concentration of 0.5% -1%, yeast extract with a mass concentration of 0.5% -1%, monopotassium phosphate with a mass concentration of 0.02% -0.1%, and calcium carbonate with a mass concentration of 0.02% -0.1% as culture medium components.
4. A method for preparing an antibacterial gel composition according to any one of claims 1 to 3, comprising the steps of:
and adding chlorhexidine gluconate into a mixed solvent of water and ethanol to be uniformly dissolved, heating to 50-80 ℃, adding cyclodextrin and polysiloxane quaternary ammonium salt, uniformly stirring and dissolving, cooling to below 60 ℃, sequentially adding the notoginseng fermentation extract, the rosewood heart wood extract and the frankincense extract, uniformly stirring and mixing, and standing for more than 24 hours to obtain the antibacterial gel composition.
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| CN108420980A (en) * | 2018-05-30 | 2018-08-21 | 武汉润禾生物医药有限公司 | It is a kind of treat skin injury, bacterium infection antibacterial ointment and preparation method thereof |
| CN111620988A (en) * | 2020-06-15 | 2020-09-04 | 张玉花 | Long-acting antibacterial dressing and preparation method thereof |
| CN112245495A (en) * | 2020-11-21 | 2021-01-22 | 陕西远志医药生物工程有限公司 | Slow-release antibacterial gel and preparation method thereof |
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| CN111620988A (en) * | 2020-06-15 | 2020-09-04 | 张玉花 | Long-acting antibacterial dressing and preparation method thereof |
| CN112245495A (en) * | 2020-11-21 | 2021-01-22 | 陕西远志医药生物工程有限公司 | Slow-release antibacterial gel and preparation method thereof |
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| 三七乳香合剂镇痛抗炎作用的实验研究;光民;储金秀;韩淑英;;河北医药;20150526;37(10);1458-1460 * |
| 聚硅氧烷季铵盐的合成及其抗菌性;李俊英, 李天铎, 张庆思, 朱晓丽, 祝德义, 侯同刚;日用化学工业;20040620;34(03);154-156 * |
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