CN104415265A - Ointment for treating onychomycosis and preparation method thereof - Google Patents

Abstract

The invention provides an ointment for treating onychomycosis and a preparation method thereof. The ointment comprises following raw material medicines, by weight, 16-22 parts of barks of pseudolarix kaempferi, 15-25 parts of pomegranate peel, 10-20 parts of radix stemonae, 20-40 parts of sophora flavescens, 10-20 parts of alums, 15-25 parts of impatiens balsamina, 10-20 parts of fructus xanthii, 10-20 parts of fructus kochiae and 10-20 parts of fructus cnidii, The ointment is prepared through following steps: (A) mixing the pseudolarix kaempferi, the pomegranate peel, the radix stemonae, the sophora flavescens, the alums, the impatiens balsamina, the fructus xanthii, the fructus kochiae and the fructus cnidii according to the weight parts and crushing the raw materials into powders in more than 100 meshes; (B) melting Vaseline by four times of the raw material medicine powders at 38-60 DEG C, adding the raw material powders with stirring quickly and uniformly, and cooling the raw material powders to obtain the ointment. The ointment is used in a manner of being coated on affected parts for 3 times per day.

Description

A kind of ointment for the treatment of tinea unguium and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, be specially a kind of ointment for the treatment of tinea unguium and preparation method thereof.

Background technology

Tinea unguium, is also tinea unguium, and the traditional Chinese medical science claims " tinea unguium ", is then tinea unguium now, and it is that the infected by microbes being called pathogenic fungi by a large class causes.Tinea unguium pathological changes starts from first far-end, lateral margin or first pleat portion, shows as first color and paramophia.Generally start morbidity with 1-2 finger (toe) first, severe one all refers to (toe), and first all can be suffered from.Ill deck tarnishes, and with the passing of time deck becomes fragile and breakage comes off.Easy recurrence, can attempt the medicine containing the clean skin composition of health, winter in spring easily recurs or increases the weight of, and many alleviations summer and autumn.Many in canescence, and tarnish; Deck thickens significantly, and surface is uneven.Its matter ravels, and often has keratin and detrital deposit under first.Sometimes, deck can be separated with nail matrix.

Often mistaken ideas are existed for tinea unguium, mainly comes from antifungal drug such as griseofulvin etc. previously and often can cause liver injury.From latter stage in last century, the appearance of the novel antifungal drugs treatment of tinea unguium is occurred revolutionary change.These medicines are incorporated into collenchyme very soon after entering human body carries out sterilizing or Antifungi growth, decreases the damage to liver, kidney largely.The side effect of these novel antifungal drugs and general antibiotics no significant difference.The medicine that Systemic administration is conventional has the medicines such as itraconazole, terbinafine, fluconazol, ketoconazole.

Summary of the invention

The object of this invention is to provide a kind of determined curative effect, have no side effect, technique simply ointment for the treatment of tinea unguium and preparation method thereof.

The present invention treats the crude drug of ointment by following parts by weight of tinea unguium: Cortex Pseudolaricis 16 ~ 22 parts, Pericarpium Granati 15 ~ 25 parts, the Radix Stemonae 10 ~ 20 parts, Radix Sophorae Flavescentis 20 ~ 40 parts, 10 ~ 20 parts, Alumen, Flos Impatientis 15 ~ 25 parts, Fructus Xanthii 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts are made.

As optimization, the ointment for the treatment of tinea unguium, is made up of the crude drug of following parts by weight: Cortex Pseudolaricis 18 parts, Pericarpium Granati 20 parts, the Radix Stemonae 15 parts, Radix Sophorae Flavescentis 30 parts, 16 parts, Alumen, Flos Impatientis 18 parts, Fructus Xanthii 16 parts, the Fructus Kochiae 15 parts, Fructus Cnidii 16 parts.

The preparation method of the ointment of this treatment tinea unguium comprises the following steps:

A, by described in Cortex Pseudolaricis, Pericarpium Granati, the Radix Stemonae, Radix Sophorae Flavescentis, Alumen, Flos Impatientis, Fructus Xanthii, the Fructus Kochiae, Fructus Cnidii parts by weight mixing, be ground into the medicated powder of more than 100 orders;

B, to be melted at 38 DEG C ~ 60 DEG C by the vaseline being four times in described medicated powder parts by weight, add the medicated powder of described parts by weight, rapid stirring is even, cools and get final product.During use, ointment is coated onto sufferer place, every day three times.

In the ointment of invention treatment tinea unguium, Cortex Pseudolaricis has parasite killing, itching-relieving efficacies, controls scabies pruritus.

Pericarpium Granati astringing intestine to stop diarrhea, hemostasis, anthelmintic.Control chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.

The Radix Stemonae cures mainly nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendum Pruritus.

Radix Sophorae Flavescentis heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.

Alumen Alumen sour-puckery flavor cold in nature, has stronger astriction.The traditional Chinese medical science is thought, Alumen has removing toxic substances parasite killing, quick-fried wet antipruritic, hemostasis antidiarrheal, effect of heat clearing away expectorant.

Flos Impatientis expelling wind and removing dampness; Promoting blood circulation and stopping pain; Removing toxic substances parasite killing.Main air wets disabled wilted limbs; Waist side of body pain; Women closes stomachache; Postnatal blood stasis is not to the greatest extent; Traumatic injury; Fracture; Skin sore; Venom; Leucorrhea; Fungal infection of hand and foot; Tinea unguium.

Fructus Xanthii acrid in the mouth, hardship, warm in nature, poisonous.Return lung meridian.There is the function of the dehumidifying of loose wind, understand things pain-stopping.Raw Fructus Xanthii is strong with wind-repellent itching-relieving power.Be usually used in itchy skin eruption and other dermatosiss.

Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.

Fructus Cnidii warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.Said medicine coordinates, and may be used for treating tinea unguium.Treat tinea unguium after soaking with 30% glacial acetic acid relative to employing Flos Impatientis, curative effect is more remarkable.

Pertinent clinical data is as follows:

Totally 180 examples, man 101 example, female 79 example; 28 ~ 57 years old age, average (45.39 ± 16.85) year; The course of disease 3 ~ 17 years, average (3.42 ± 2.19) year.Three groups of general clinical datas are through statistical procedures there was no significant difference (P > 0.05).

Diagnostic criteria: clinical manifestation be deck muddy, thicken, surface irregularity, variable color, deck destroy, incomplete, come off, tilt and paronychia.

Therapeutic Method: each 45 examples of first three groups, accept embodiment 1, embodiment 2, embodiment 3 medicinal ointment therapy respectively, external is a course for the treatment of in three times 30 days on the one.Contrast groups 45 example employing Flos Impatientis with external application after 30% glacial acetic acid or soaking in rice vinegar, is changed dressings 1 ~ 2 time, is observed its curative effect after 1 month in tinea unguium every day.

Criterion of therapeutical effect: effective: sick first disappears, and new fingernail major part grows, without pruritus; Take a turn for the better: part fingernail grows, and become fragile improvement, has no and be separated with nail matrix, without eating hollow, without pruritus; Invalid: after medication, symptom is comparatively treated front without significant change.

After four groups of case treatments, comparitive study statistical result is as follows:

Group	Embodiment 1	Embodiment 2	Embodiment 3	Contrast groups
					Number of cases	45	45	45	45
Effective (n%)	41（91.1%）	42（93.4%）	40（88.9%）	36（80.0%）
					Effectively (n%)	3（86.7%）	1（2.2%）	4（8.9%）	4（8.9%）
Invalid (n%)	1（2.2%）	2（4.4%）	1（2.2%）	5（11.1%）
					Anaphylaxis (n%)	0（0%）	0 （0%）	0 （0%）	0（0%）
Total effective rate (n%)	97.8%	95.6%	97.8%	88.9%

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1:

Get Cortex Pseudolaricis 18 grams, Pericarpium Granati 20 grams, the Radix Stemonae 15 grams, Radix Sophorae Flavescentis 30 grams, 16 grams, Alumen, Flos Impatientis 18 grams, Fructus Xanthii 16 grams, the Fructus Kochiae 15 grams, Fructus Cnidii 16 grams.Grinding and processing becomes the medicated powder of more than 100 orders.

First melted at 50 DEG C by 450 grams of vaseline, add medicated powder, rapid stirring is even, cooling.

Embodiment 2:

Get Cortex Pseudolaricis 16 grams, Pericarpium Granati 15 grams, the Radix Stemonae 10 grams, Radix Sophorae Flavescentis 20 grams, 10 grams, Alumen, Flos Impatientis 15 grams, Fructus Xanthii 10 grams, the Fructus Kochiae 10 grams, Fructus Cnidii 10 grams.Grinding and processing becomes the medicated powder of more than 100 orders.

First melted at 38 DEG C by 360 grams of vaseline, add medicated powder, rapid stirring is even, cooling.

Embodiment 3:

Get Cortex Pseudolaricis 22 grams, Pericarpium Granati 25 grams, the Radix Stemonae 20 grams, Radix Sophorae Flavescentis 40 grams, 20 grams, Alumen, Flos Impatientis 25 grams, Fructus Xanthii 20 grams, the Fructus Kochiae 20 grams, Fructus Cnidii 20 grams.Grinding and processing becomes the medicated powder of more than 100 orders.

First melted at 60 DEG C by 630 grams of vaseline, add medicated powder, rapid stirring is even, cooling.

Claims (3)

1. treat an ointment for tinea unguium, it is characterized in that being made up of the crude drug of following parts by weight: Cortex Pseudolaricis 16 ~ 22 parts, Pericarpium Granati 15 ~ 25 parts, the Radix Stemonae 10 ~ 20 mark, Radix Sophorae Flavescentis 20 ~ 40 parts, 10 ~ 20 parts, Alumen, Flos Impatientis 15 ~ 25 parts, Fructus Xanthii 10 ~ 20 parts, the Fructus Kochiae 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts.

2. treat the ointment of tinea unguium according to claim 1, it is characterized in that being made up of the crude drug of following parts by weight: Cortex Pseudolaricis 18 parts, Pericarpium Granati 20 parts, the Radix Stemonae 15 mark, Radix Sophorae Flavescentis 30 parts, 16 parts, Alumen, Flos Impatientis 18 parts, Fructus Xanthii 16 parts, the Fructus Kochiae 15 parts, Fructus Cnidii 16 parts.

3. prepare an ointment method for the treatment of tinea unguium described in claim 1, it is characterized in that comprising the following steps:

A, by described in Cortex Pseudolaricis, Pericarpium Granati, the Radix Stemonae, Radix Sophorae Flavescentis, Alumen, Flos Impatientis, Fructus Xanthii, the Fructus Kochiae, Fructus Cnidii parts by weight mixing, be ground into the medicated powder of more than 100 orders;

B, to be melted at 38 DEG C ~ 60 DEG C by the vaseline being four times in described medicated powder parts by weight, add the medicated powder of described parts by weight, rapid stirring is even, cools and get final product.