CN104257931A - Orthopedic traumatic injury external application patch and preparation method thereof - Google Patents
Orthopedic traumatic injury external application patch and preparation method thereof Download PDFInfo
- Publication number
- CN104257931A CN104257931A CN201410568044.4A CN201410568044A CN104257931A CN 104257931 A CN104257931 A CN 104257931A CN 201410568044 A CN201410568044 A CN 201410568044A CN 104257931 A CN104257931 A CN 104257931A
- Authority
- CN
- China
- Prior art keywords
- traumatic injury
- parts
- application agent
- radix
- hour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000014674 injury Diseases 0.000 title claims abstract description 65
- 230000008736 traumatic injury Effects 0.000 title claims abstract description 62
- 238000002360 preparation method Methods 0.000 title claims description 22
- 230000000399 orthopedic effect Effects 0.000 title abstract 6
- 239000004863 Frankincense Substances 0.000 claims abstract description 37
- 239000003814 drug Substances 0.000 claims abstract description 35
- 241001261538 Lycodon rufozonatus Species 0.000 claims abstract description 29
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 8
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 8
- 239000011505 plaster Substances 0.000 claims description 63
- 239000000843 powder Substances 0.000 claims description 57
- 239000003795 chemical substances by application Substances 0.000 claims description 49
- 241000717739 Boswellia sacra Species 0.000 claims description 30
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 22
- 229910052802 copper Inorganic materials 0.000 claims description 22
- 239000010949 copper Substances 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 22
- 241000511967 Tylophora Species 0.000 claims description 21
- 241001480581 Marasmius Species 0.000 claims description 20
- 241000566151 Pandion Species 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 15
- 239000000284 extract Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 239000012530 fluid Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 9
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 7
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 7
- 229920000742 Cotton Polymers 0.000 claims description 7
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 7
- 239000011425 bamboo Substances 0.000 claims description 7
- 238000001354 calcination Methods 0.000 claims description 7
- 238000005520 cutting process Methods 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 230000000149 penetrating effect Effects 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 230000000717 retained effect Effects 0.000 claims description 7
- 238000003892 spreading Methods 0.000 claims description 7
- 230000007480 spreading Effects 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 7
- 244000082204 Phyllostachys viridis Species 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 32
- 208000002193 Pain Diseases 0.000 abstract description 26
- 230000036407 pain Effects 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 16
- 239000008280 blood Substances 0.000 abstract description 14
- 210000004369 blood Anatomy 0.000 abstract description 12
- 230000017531 blood circulation Effects 0.000 abstract description 11
- 240000007551 Boswellia serrata Species 0.000 abstract description 8
- 210000000988 bone and bone Anatomy 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 abstract description 5
- 230000000144 pharmacologic effect Effects 0.000 abstract description 4
- 238000011084 recovery Methods 0.000 abstract description 3
- 241001254604 Angelica pubescens Species 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 241000234276 Curculigo Species 0.000 abstract 1
- 241000501743 Gentiana macrophylla Species 0.000 abstract 1
- 241000566150 Pandion haliaetus Species 0.000 abstract 1
- 241000203383 Schefflera Species 0.000 abstract 1
- 241000331436 Tylophora floribunda Species 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- ZLIBICFPKPWGIZ-UHFFFAOYSA-N pyrimethanil Chemical compound CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 ZLIBICFPKPWGIZ-UHFFFAOYSA-N 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000008961 swelling Effects 0.000 description 9
- 210000003205 muscle Anatomy 0.000 description 8
- 208000006820 Arthralgia Diseases 0.000 description 6
- 241001330002 Bambuseae Species 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 208000010392 Bone Fractures Diseases 0.000 description 5
- 206010017076 Fracture Diseases 0.000 description 5
- 208000025747 Rheumatic disease Diseases 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000000552 rheumatic effect Effects 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 231100000862 numbness Toxicity 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- NBGQZFQREPIKMG-UHFFFAOYSA-N 3beta-hydroxy-beta-boswellic acid Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CCC3C21C NBGQZFQREPIKMG-UHFFFAOYSA-N 0.000 description 2
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 2
- NGSWKAQJJWESNS-UHFFFAOYSA-N 4-coumaric acid Chemical compound OC(=O)C=CC1=CC=C(O)C=C1 NGSWKAQJJWESNS-UHFFFAOYSA-N 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- NBGQZFQREPIKMG-PONOSELZSA-N Boswellic acid Chemical compound C1C[C@@H](O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C NBGQZFQREPIKMG-PONOSELZSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000029549 Muscle injury Diseases 0.000 description 2
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 2
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 2
- 241000293001 Oxytropis besseyi Species 0.000 description 2
- 241000180649 Panax notoginseng Species 0.000 description 2
- 235000003143 Panax notoginseng Nutrition 0.000 description 2
- 241000203379 Schefflera arboricola Species 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 229920001206 natural gum Polymers 0.000 description 2
- 229940100243 oleanolic acid Drugs 0.000 description 2
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- LFJQCDVYDGGFCH-JTQLQIEISA-N (+)-β-phellandrene Chemical compound CC(C)[C@@H]1CCC(=C)C=C1 LFJQCDVYDGGFCH-JTQLQIEISA-N 0.000 description 1
- LFJQCDVYDGGFCH-SNVBAGLBSA-N (+/-)-beta-Phellandrene Natural products CC(C)[C@H]1CCC(=C)C=C1 LFJQCDVYDGGFCH-SNVBAGLBSA-N 0.000 description 1
- CXENHBSYCFFKJS-GZCJILEISA-N (3E)-3,7,11-trimethyldodeca-1,3,6,10-tetraene Chemical compound CC(C)=CCCC(C)=CC\C=C(/C)C=C CXENHBSYCFFKJS-GZCJILEISA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- HRGUSFBJBOKSML-UHFFFAOYSA-N 3',5'-di-O-methyltricetin Chemical compound COC1=C(O)C(OC)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 HRGUSFBJBOKSML-UHFFFAOYSA-N 0.000 description 1
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- XUGISPSHIFXEHZ-UHFFFAOYSA-N 3beta-acetoxy-cholest-5-ene Natural products C1C=C2CC(OC(C)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 XUGISPSHIFXEHZ-UHFFFAOYSA-N 0.000 description 1
- YEYCQJVCAMFWCO-UHFFFAOYSA-N 3beta-cholesteryl formate Natural products C1C=C2CC(OC=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 YEYCQJVCAMFWCO-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000566143 Accipitridae Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000255791 Bombyx Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000131329 Carabidae Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241000334161 Cercis chinensis Species 0.000 description 1
- 241000270292 Colubridae Species 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 1
- 239000005751 Copper oxide Substances 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241000123586 Dipsacaceae Species 0.000 description 1
- 241000123589 Dipsacus Species 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010072132 Fracture pain Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241000967672 Gentiana crassicaulis Species 0.000 description 1
- 241000290619 Gentiana dahurica Species 0.000 description 1
- 241000501719 Gentiana straminea Species 0.000 description 1
- 241001071804 Gentianaceae Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000233062 Gymnopus androsaceus Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 244000153234 Hibiscus abelmoschus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- 108010025252 Kassinin Proteins 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000283956 Manis Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- NWBJYWHLCVSVIJ-UHFFFAOYSA-N N-benzyladenine Chemical compound N=1C=NC=2NC=NC=2C=1NCC1=CC=CC=C1 NWBJYWHLCVSVIJ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 208000002565 Open Fractures Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- IDDMFNIRSJVBHE-UHFFFAOYSA-N Piscigenin Natural products COC1=C(O)C(OC)=CC(C=2C(C3=C(O)C=C(O)C=C3OC=2)=O)=C1 IDDMFNIRSJVBHE-UHFFFAOYSA-N 0.000 description 1
- 241001250596 Pleione Species 0.000 description 1
- HCXVJBMSMIARIN-LWINXXIXSA-N Poriferasterol Natural products CC[C@H](C=C[C@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C HCXVJBMSMIARIN-LWINXXIXSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000131808 Scolopendra Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000887536 Stichopus horrens Species 0.000 description 1
- 208000021945 Tendon injury Diseases 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- SSEUDFYBEOIWGF-AWEZNQCLSA-N Tylophorine Chemical compound C1=C(OC)C(OC)=CC2=C(C=C(C(OC)=C3)OC)C3=C(C[C@H]3N(CCC3)C3)C3=C21 SSEUDFYBEOIWGF-AWEZNQCLSA-N 0.000 description 1
- SSEUDFYBEOIWGF-CQSZACIVSA-N Tylophorine Natural products C1=C(OC)C(OC)=CC2=C(C=C(C(OC)=C3)OC)C3=C(C[C@@H]3N(CCC3)C3)C3=C21 SSEUDFYBEOIWGF-CQSZACIVSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- LFJQCDVYDGGFCH-UHFFFAOYSA-N beta-phellandrene Natural products CC(C)C1CCC(=C)C=C1 LFJQCDVYDGGFCH-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 208000010217 blepharitis Diseases 0.000 description 1
- 159000000007 calcium salts Chemical group 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- XUGISPSHIFXEHZ-VEVYEIKRSA-N cholesteryl acetate Chemical compound C1C=C2C[C@@H](OC(C)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 XUGISPSHIFXEHZ-VEVYEIKRSA-N 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 229910000431 copper oxide Inorganic materials 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 1
- 229960004976 desogestrel Drugs 0.000 description 1
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 210000000610 foot bone Anatomy 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000035929 gnawing Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 239000004021 humic acid Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 210000004417 patella Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002315 pressor effect Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000009286 sanguis draxonis Substances 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 235000008521 threonine Nutrition 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- BMCJATLPEJCACU-UHFFFAOYSA-N tricin Natural products COc1cc(OC)c(O)c(c1)C2=CC(=O)c3c(O)cc(O)cc3O2 BMCJATLPEJCACU-UHFFFAOYSA-N 0.000 description 1
- 229930182493 triterpene saponin Natural products 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000014393 valine Nutrition 0.000 description 1
- 150000003680 valines Chemical class 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000009306 yunnan baiyao Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an orthopedic traumatic injury external application patch. The orthopedic traumatic injury external application patch is prepared from the following raw materials in parts by weight: 6-18 parts of dinodon rufozonatum snake, 5-12 parts of tylophora floribunda, 6-12 parts of frankincense, 9-15 parts of pubescent angelica root, 4-8 parts of cupric scala, 8-12 parts of osprey bone, 6-10 parts of microphale pilosipe, 8-12 parts of scandent schefflera stem and leaf, 9-15 parts of large-leaf gentian root and 6-9 parts of common curculigo rhizome. The invention further has the excellent effects that the orthopedic traumatic injury external application patch is prepared by many traditional Chinese medicines, and is reasonable in combination, excellent in curative effect of traumatic injury, concurrent in the treatment of symptoms and root causes, quick in taking effect, free of toxic or side effects, and free of relapse after recovery; the orthopedic traumatic injury external application patch has the pharmacological effects of blood circulation activation, blood stasis dissipation, anti-inflammation and pain alleviation, and is suitable for the treatment of traumatic injury; the orthopedic traumatic injury external application patch is facile in medicine source and low in cost of medicinal materials, and can reduce the burden on patients.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of orthopaedics traumatic injury external plaster application agent and preparation method.
Background technology
Traumatic injury is orthopaedics common frdquently encountered disease, and for attacking outside brute force, local muscle arteries and veins muscle injury, venation is unfavorable, and stagnation of QI-blood forms.Clinical in local pain, swelling is livid purple, and articular muscle obstacle is main manifestations.Traumatic injury belongs to the traditional Chinese medical science " muscle and tendon injury " category.The traditional Chinese medical science is thought, primary disease mostly is qi depression to blood stasis, and blockage of the vessel is so-called, and when with blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain is for controlling.Chinese traditional treatment traumatic injury has the history of several thousand, ancient claims the introduction that " traumatic injury " is all wounds, how because of External Force Acting, or overexerts when self fault and causes.The muscles and bones trauma that the traditional Chinese medical science causes in human body because of External Force Acting all, swelling and pain due to blood stasis, disharmony between QI and blood, blockage of main and collateral channels, so that internal organs are impaired etc., are referred to as traumatic injury.
Through the ages, personal traumatic injury, fracture, be a kind of arising suddenly, cause the critically ill urgency of life, disability is final, and the disease of refractory.Just have the saying of 100 days injured in the sinews or bones from ancient times, up to now, also do not have one real, system, complete, overall therapy system, does not have a kind ofly to treat the medicine that traumatic injury has unique curative effect yet.The Therapeutic Principle of traumatic injury: the wounded, critical serious symptom, then when emergency is for first.The method for the treatment of: first reason hinders first aid, causing resuscitation with aromatic drugs, dredging the meridian, rescues to obtain a slim chance of survival, carries out reunion of bone immediately, debridement finishing compound, admittedly de-wound, it is top priority that 16 methods are cured in the first aid of enforcement wound.
The Chinese invention patent document of publication number CN 102302752 A (application number 201110241852.6) discloses a kind of plaster for treating traumatic injuries, and he is made up of following herbal component: Radix Notoginseng 6-9 gram, thousand Rhizoma Zingiberis Recens 6-9 gram, Rhizoma Et Radix Notopterygii 6-9 gram, Bombyx Batryticatus 6-9 gram, Radix Saposhnikoviae 6-9 gram, Radix Aconiti 10-14 gram, Radix Aconiti Kusnezoffii 10-14 gram, Scolopendra 2-4 gram, Rhizoma Sparganii 6-9 gram, Rhizoma Curcumae 6-9 gram, Flos Carthami 6-9 gram, Semen Persicae 6-9 gram, Rhizoma Alpiniae Officinarum 6-9 gram, Rhizoma Drynariae 6-9 gram, Radix Paeoniae Rubra 6-9 gram, Semen Ricini 6-9 gram, Rhizoma Curcumae Longae 6-8 gram; Semen Strychni liquid medicine 10-14 gram, Squama Manis 6-9 gram, Fructus Caryophylli 6-9 gram, Cortex Cinnamomi 6-9 gram, Borneolum Syntheticum 6-9 gram, Olibanum 6-9 gram, Moschus 1-3 gram.The Chinese invention patent document of publication number CN 101804158 A (application number 201010152062.6) discloses a kind of ointment for injuries, is made up: Os Draconis 30g, Cortex Albiziae 35g of the medicine of following weight proportion, Rhizoma Pleiones Yunnanensis 30g, Radix Dipsaci 35g ， female ground beetle 27g, Rhizoma Dioscoreae Septemlobae 35g, Pyritum 12g, Radix Berchemiae Giraldianae 30g, Radix Cyathulae 25g, Bos taurus domesticus Gmelin 37g, Cortex cercis chinensis 35g, Radix Polygalae 30g, Rhizoma Drynariae 30g, Sanguis Draxonis 25g, Borneolum Syntheticum 25g, Aerugo 20g, Camphora 45.The Chinese invention patent document of publication number CN 103417648 A (application number 201310390225.8) discloses a kind of Chinese medicine preparation being used for the treatment of traumatic injury, be made up of the raw material of following weight parts: Herba speranskiae tuberculatae 40-60 part, Rhizoma Polygoni Cuspidati 40-60 part, Lignum Sappan 40-60 part, Olibanum (processed with vinegar) 40-60 part, Myrrha (processed with vinegar) 40-60 part, Caulis Spatholobi 40-60 part.
Modern medicine mainly takes the treatment of anti-inflammation analgesia medicine, comprises non-steroid antiinflammatory immunoregulatory drugs, steroidal anti-inflammatory immune substance, desogestrel etc., but such drug side effect is comparatively large, takes the function that can affect many organs and system for a long time in a large number.The Chinese medicine for the treatment of traumatic injury common are: Radix Notoginseng powder, YUNNAN BAIYAO, repercussive and analgesic tincture etc., there is good reducing swelling and alleviating pain, promote the effects such as body tissue healing, but treatment is long for the course for the treatment of, effective speed slowly, thus causes injury region muscle, tough with loss in various degree.
Summary of the invention
The object of this invention is to provide a kind of short treating period, curative effect high, without the orthopaedics traumatic injury external plaster application agent of side reaction.
Technical scheme of the present invention is:
Orthopaedics traumatic injury external plaster application agent, is prepared from by following raw material, is mass parts: Dinodon rufozonatum (Cantor) 6-18, tylophora florlbunda 5-12, Olibanum 6-12, Radix Angelicae Pubescentis 9-15, copper chippings 4-8, Os Pandion haliaeti 8-12, Marasmius equicrinis Muell. 6-10, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8-12, Radix Gentianae Macrophyllae 9-15, white Rhizoma Curculiginis 6-9.
In preferred scheme, Dinodon rufozonatum (Cantor) 10-14, tylophora florlbunda 7-10, Olibanum 8-10, Radix Angelicae Pubescentis 11-13, copper chippings 5-7, Os Pandion haliaeti 9-11, Marasmius equicrinis Muell. 7-9, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 9-11, Radix Gentianae Macrophyllae 11-13, white Rhizoma Curculiginis 7-8.
Be more preferably, Dinodon rufozonatum (Cantor) 12, tylophora florlbunda 8.5, Olibanum 9, Radix Angelicae Pubescentis 12, copper chippings 6, Os Pandion haliaeti 10, Marasmius equicrinis Muell. 8, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10, Radix Gentianae Macrophyllae 12, white Rhizoma Curculiginis 7.5.
The above-mentioned preparation method for orthopaedics traumatic injury external plaster application agent, step is as follows:
(1) decaptitated by Dinodon rufozonatum (Cantor), remove the peel, clean, cutting, mixes thoroughly with ethanol, slightly vexed, when little fire is fried to surperficial buff, takes out, spreading for cooling; Get Olibanum and add Chinese liquor pouring profit, be sucked to wine, cure with low baking temperature, extremely oil is thoroughly on paper, and matter is crisp, and tack-free is degree, is ground into fine powder and gets final product (every Olibanum block 1kg, Chinese liquor 60g);
(2) get the calcining of copper chippings slow fire, shrend, bits fall, and clean with clear water, enter in marmite to fry and see Mars, levigation, sieve, obtain fine powder 1 with Chinese liquor; Get Os Pandion haliaeti charred medicinal herb with its property retained, grind into powder, obtain fine powder 2; Get clean Marasmius equicrinis Muell., little fire dries, and is ground into fine powder 3, by fine powder 1,2,3 mix homogeneously;
(3) clean to tylophora florlbunda, Radix Angelicae Pubescentis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Gentianae Macrophyllae and white Rhizoma Curculiginis, step (2) gained mixing fine powders are placed in penetrating bag, together marmite is placed in the Dinodon rufozonatum (Cantor) after step (1) processes, the clear water adding 3 times amount soaks, be placed on stove fire, big fire decocts twice, and first time decocts 2-3 hour, second time decocts 1-2 hour, twice medicinal liquid mixing, filters, obtains decocting liquid; Gained decocting liquid is through being condensed into fluid extract;
(4) take the plaster substrate of 2.5 times amount crude drug, after melting with slow fire, cooling, adds fluid extract and step (1) gained frankincense powder while stirring, stirs;
(5) dip the plaster prepared with bamboo let, spread out on cotton, amount to packaging, put the storage of shady and cool place, obtain external plaster application agent.
The preparation method of above-mentioned orthopaedics traumatic injury external plaster application agent, preferred scheme is, in step (1), Chinese liquor drenches profit 1-3 hour (preferably drench profit 1.5-2.5 hour, the pouring be more preferably moistens 2 hours).
The preparation method of above-mentioned orthopaedics traumatic injury external plaster application agent, preferred scheme is, in step (1), low baking temperature cures 12-24 hour (preferably cure 16-20 hour, what be more preferably cures 18 hours).
The preparation method of above-mentioned orthopaedics traumatic injury external plaster application agent, preferred scheme is, the middle 160-200 mesh sieve excessively of step (2) (preferred 170-190 mesh sieve excessively, mistake 180 mesh sieve be more preferably).
The preparation method of above-mentioned orthopaedics traumatic injury external plaster application agent, preferred scheme is, in step (3), clear water soak time is 0.5-2.5 hour (preferred soak time is 1-2 hour, and the soak time be more preferably is 1.5 hours).
The preparation method of above-mentioned orthopaedics traumatic injury external plaster application agent, preferred scheme is, is cooled to 60-80 DEG C (be preferably cooled to 65-75 DEG C, what be more preferably is cooled to 70 DEG C) in step (4).
Present invention also offers described external plaster application agent and prepare the application in orthopaedics traumatic injury medicine.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Tylophora florlbunda: base is former: be the root of asclepiadaceae Tylophora plant tylophora florlbunda.Composition: containing 2,3,5,6-tetramethoxyphenanthro[9,10:6',7' and tylophorine.The property of medicine: pungent, temperature.Mild toxicity.Function cures mainly: dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling.Cure mainly cough with asthma abundant expectoration, diphtheria, infantile convulsion, rheumatic arthralgia, traumatic injury, fracture, venom, carbuncle furuncle, acute conjunctivitis, stomatitis, edema, hepatosplenomegaly.Compatibility and incompatibility of drugs: " Zhejiang conventional medical herbs among the people ": " anemia of pregnant woman and weakling are cautious use of.”
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): base is former: be root or the stem and leaf of Araliaceae Schefflera plant schefflera arboricola.Composition: containing sickleleaf celery alcohol in schefflera arboricola; Also containing (E)--farnesene, poriferasterol.2 Triterpene saponins: 3-O-[a-L-rhamnopyranosyl-(la)--D-glucopyranosiduronic acid base] oleanolic acid 28-O--D-pyranglucoside are contained, 3-O-[a-L-arabopyranose base-(la)--D-glucopyranosiduronic acid base] oleanolic acid 28-O--D-pyranglucoside in leaf and stem.Cell kassinin kinin element class is also had, trans-Semen Maydis purine, benzyladenine in leaf.The property of medicine: pungent, sweet, micro-hardship, temperature.Function cures mainly: wind-expelling pain-stopping, promoting blood circulation and detumescence.Cure mainly rheumatic arthralgia, headache, toothache, epigastric pain, dysmenorrhea, puerperal abdonimal pain, treating swelling and pain by traumatic injury, fracture, skin ulcer swells.Compatibility and incompatibility of drugs: " Guangxi conventional medical herbs handbook among the people ": " be not taken by pregnant women.”
White Rhizoma Curculiginis: base is former: be the root of the large Stichopus variegatus (Sempen) of Dipsacaceae thorn Genus Dipsacus plant.The property of medicine: sweet, micro-hardship, temperature.Function cures mainly: lung benefiting spleen invigorating, kidney invigorating and YANG supporting, relaxing muscles and tendons to promote blood circulation.Cure mainly cough due to deficiency of the lung, insufficiency of the spleen dyspepsia, impotence due to deficiency of the kidney, leukorrhagia, uterine prolapse, traumatic injury, fracture.
Copper chippings: base is former: be the chip come off when forging copper.Composition: main component is metallic copper, in atmosphere by the effect of steam, oxygen, carbon dioxide, the normal coating material such as copper oxide, curpic carbonate being covered with trace on the surface.The property of medicine: bitter, flat, poisonous.Function cures mainly: synthetism dissipating blood stasis.Cure mainly injured bone, congestion swells and ache, traumatic hemorrhage, marginal blepharitis eye.Compatibility and incompatibility of drugs: " book on Chinese herbal medicine converges and says ": " this is the agent of metal and stone, and Discontinue medication as soon as get effect can not cross clothes.”
Dinodon rufozonatum (Cantor): base is former: be the entirety of Colubridae animal Dinodon rufozonatum (Cantor).Nature and flavor: sweet in the mouth; Warm in nature.Gui Jing: the heart; Spleen channel.Function cures mainly: wind-damp dispelling; Pain relieving; Removing toxic substances sore.Main air wet arthritis; Overall pain; Tuberculous lymphadenitis; Chronic fistula; Ulcer; Scabies.Pharmacological action: 1. antiinflammatory action, Dinodon rufozonatum (Cantor) water, alcohol extract all have obvious antiinflammatory action.2. analgesic activity; 3. calm, syngignoscism; 4. anti-frightened Jue effect.
Olibanum: base is former: be the gum resin of olive subject plant Boswellia carterii Birdw.Nature and flavor: arduous, temperature.Gui Jing: enter the heart, liver, spleen channel.Chemical analysis: resinous 60 ~ 70%, natural gum 27 ~ 35%, volatile oil 3 ~ 8%.The main component of resin is free α, β-boswellic acid 33%, in conjunction with boswellic acid 1.5%, and olibanoresene 33%.Natural gum is calcium salt and the magnesium salt 20% of arabitic acid, bassorin 6%; In addition, still containing amaroid 0.5%.Volatile oil is faint yellow, has fragrance, and containing pinene, racemization-limonene and α, β-phellandrene, its main fragrance ingredient is not bright.Function cures mainly; Regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Radix Angelicae Pubescentis: base is former: this product is the dry root of samphire Angelica pubescens.Nature and flavor: pungent, bitter, tepor.Gui Jing: return kidney, urinary bladder channel.Effect: expelling wind and removing dampness, numbness relieving and pain relieving.Cure mainly: for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.Pharmacological action: 1, calmness, hypnosis, analgesia, antiinflammatory action; 2, inhibitory action is had to isolated frog heart.Decoct, when frog lower limb pours into, has pressor effect; 3, some antibacterial action is had to Bacillus tuberculosis.
Os Pandion haliaeti: base is former: be the skeleton of Accipitridae animal fish hawk.Nature and flavor: salty; Flat.Gui Jing: kidney channel.Function cures mainly: reuniting the fractured tendons and bones, detumescence pain.Main traumatic injury, fracture.
Marasmius equicrinis Muell.: base is former: Mycophyta Basidiomycetes Agaricales Agaricaceae Marasmius equicrinis Muell., is used as medicine with shoestring.Nature and flavor: micro-hardship, warm in nature.Gui Jing: Liver Channel.Function cures mainly: analgesic therapy of invigorating blood circulation.Main traumatic injury; Fracture pain; Migraine, various neuralgia, lumbago and skelalgia, rheumatic arthralgia.Chemical analysis: Marasmius androsaceus (L.ex Fr.) Fr. mycelia, containing mannitol in shoestring, cholesteryl acetate, glycine, aspartic acid, threonine, valines etc., also isolate cupreol from mycelium, Palmic acid, 28 carbonic acid, p-hydroxycinnamic acid and tricin, separately containing humic acid.
Radix Gentianae Macrophyllae: base is former: this product is the dry root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana straminea maxim, gentiana crassicaulis Duthie or Gentiana dahurica.Nature and flavor: pungent, bitter are flat.Gui Jing: return stomach, liver, gallbladder meridian.Effect: wind-damp dispelling, clearing away damp-heat, stopping numbness pain.Cure mainly: for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, and day feeds hectic fever, and infantile malnutrition generates heat.
External plaster application agent scientific formula provided by the invention, preparation method is simple, and products obtained therefrom is easy to use, be easy to carry.In addition, excellent results of the present invention also shows:
1,the present invention adopts kinds of traditional Chinese medicines to prepare, and rationally, treatment traumatic injury curative effect is good, treating both the principal and secondary aspects of a disease, instant effect, have no side effect in collocation, does not recur after recovery from illness.
2,the present invention have invigorate blood circulation, dissipating blood stasis, antiinflammatory, pain relieving pharmacological action be applicable to treat traumatic injury.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1orthopaedics traumatic injury external plaster application agent, is prepared from by following raw material, is mass parts: Dinodon rufozonatum (Cantor) 6g, tylophora florlbunda 5g, Olibanum 6g, Radix Angelicae Pubescentis 9g, copper chippings 4g, Os Pandion haliaeti 8g, Marasmius equicrinis Muell. 6g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8g, Radix Gentianae Macrophyllae 9g, white Rhizoma Curculiginis 6g.
The orthopaedics preparation method of traumatic injury external plaster application agent:
(1) decaptitated by Dinodon rufozonatum (Cantor), remove the peel, clean, cutting, mixes thoroughly with ethanol, slightly vexed, when little fire is fried to surperficial buff, takes out, spreading for cooling; Get Olibanum and add Chinese liquor pouring profit 1 hour, be sucked to wine, cure 12 hours with low baking temperature, extremely oil is thoroughly on paper, and matter is crisp, tack-free for spending, and is ground into fine powder and gets final product (every Olibanum block 1kg, Chinese liquor 60g);
(2) get the calcining of copper chippings slow fire, shrend, bits fall, and clean with clear water, enter in marmite to fry and see Mars, levigation, cross 160 mesh sieves, obtain fine powder 1 with Chinese liquor; Get Os Pandion haliaeti charred medicinal herb with its property retained, grind into powder, obtain fine powder 2; Get clean Marasmius equicrinis Muell., little fire dries, and is ground into fine powder 3, by fine powder 1,2,3 mix homogeneously;
(3) clean to tylophora florlbunda, Radix Angelicae Pubescentis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Gentianae Macrophyllae and white Rhizoma Curculiginis, step (2) gained mixing fine powders are placed in penetrating bag, together marmite is placed in the Dinodon rufozonatum (Cantor) after step (1) processes, the clear water adding 3 times amount soaks 0.5 hour, be placed on stove fire, big fire decocts twice, and first time decocts 2-3 hour, second time decocts 1-2 hour, twice medicinal liquid mixing, filters, obtains decocting liquid; Gained decocting liquid is through being condensed into fluid extract;
(4) take the plaster substrate of 2.5 times amount crude drug, after melting with slow fire, be cooled to 60 DEG C, add fluid extract and step (1) gained frankincense powder while stirring, stir;
(5) dip the plaster prepared with bamboo let, spread out on cotton, amount to packaging, put the storage of shady and cool place, obtain external plaster application agent.
The using method of external plaster application agent of the present invention: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 4 days, changes once, within 7 days, is a course for the treatment of.
embodiment 2orthopaedics traumatic injury external plaster application agent, is prepared from by following raw material, is mass parts: Dinodon rufozonatum (Cantor) 18g, tylophora florlbunda 12g, Olibanum 12g, Radix Angelicae Pubescentis 15g, copper chippings 8g, Os Pandion haliaeti 12g, Marasmius equicrinis Muell. 10g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 12g, Radix Gentianae Macrophyllae 15g, white Rhizoma Curculiginis 9g.
The orthopaedics preparation method of traumatic injury external plaster application agent:
(1) decaptitated by Dinodon rufozonatum (Cantor), remove the peel, clean, cutting, mixes thoroughly with ethanol, slightly vexed, when little fire is fried to surperficial buff, takes out, spreading for cooling; Get Olibanum and add Chinese liquor pouring profit 3 hours, be sucked to wine, cure 24 hours with low baking temperature, extremely oil is thoroughly on paper, and matter is crisp, tack-free for spending, and is ground into fine powder and gets final product (every Olibanum block 1kg, Chinese liquor 60g);
(2) get the calcining of copper chippings slow fire, shrend, bits fall, and clean with clear water, enter in marmite to fry and see Mars, levigation, cross 200 mesh sieves, obtain fine powder 1 with Chinese liquor; Get Os Pandion haliaeti charred medicinal herb with its property retained, grind into powder, obtain fine powder 2; Get clean Marasmius equicrinis Muell., little fire dries, and is ground into fine powder 3, by fine powder 1,2,3 mix homogeneously;
(3) clean to tylophora florlbunda, Radix Angelicae Pubescentis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Gentianae Macrophyllae and white Rhizoma Curculiginis, step (2) gained mixing fine powders are placed in penetrating bag, together marmite is placed in the Dinodon rufozonatum (Cantor) after step (1) processes, the clear water adding 3 times amount soaks 2.5 hours, be placed on stove fire, big fire decocts twice, and first time decocts 2-3 hour, second time decocts 1-2 hour, twice medicinal liquid mixing, filters, obtains decocting liquid; Gained decocting liquid is through being condensed into fluid extract;
(4) take the plaster substrate of 2.5 times amount crude drug, after melting with slow fire, be cooled to 80 DEG C, add fluid extract and step (1) gained frankincense powder while stirring, stir;
(5) dip the plaster prepared with bamboo let, spread out on cotton, amount to packaging, put the storage of shady and cool place, obtain external plaster application agent.
The using method of external plaster application agent of the present invention: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 4 days, changes once, within 7 days, is a course for the treatment of.
Model case: Liu XX, female, 40 years old, people from Tai'an.Main to state: in May, 2011, because of accidentally throwing from stair, causes left foot bone to be fractured, sends to hospital and carry out bone-setting treatment, a postoperative wheat harvesting period left foot still swelling, gnawing pains take no rest, can not leave the bed on foot.Then here treatment.
Use the present embodiment gained orthopaedics traumatic injury external plaster application agent, affected part is cleaned up, gets this patch of suitable size, heat softening, be attached to affected part, within 4 days, change once, within 7 days, be a course for the treatment of.After using a course for the treatment of, left foot swelling fades, and after using two courses for the treatment of, patient's left foot can land and walk, and after January, basic rehabilitation walking freely.Patient is without any discomfort.
embodiment 3orthopaedics traumatic injury external plaster application agent, is prepared from by following raw material, is mass parts: Dinodon rufozonatum (Cantor) 10g, tylophora florlbunda 7g, Olibanum 8g, Radix Angelicae Pubescentis 11g, copper chippings 5g, Os Pandion haliaeti 9g, Marasmius equicrinis Muell. 7g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 9g, Radix Gentianae Macrophyllae 11g, white Rhizoma Curculiginis 7g.
The orthopaedics preparation method of traumatic injury external plaster application agent:
(1) decaptitated by Dinodon rufozonatum (Cantor), remove the peel, clean, cutting, mixes thoroughly with ethanol, slightly vexed, when little fire is fried to surperficial buff, takes out, spreading for cooling; Get Olibanum and add Chinese liquor pouring profit 1.5 hours, be sucked to wine, cure 16 hours with low baking temperature, extremely oil is thoroughly on paper, and matter is crisp, tack-free for spending, and is ground into fine powder and gets final product (every Olibanum block 1kg, Chinese liquor 60g);
(2) get the calcining of copper chippings slow fire, shrend, bits fall, and clean with clear water, enter in marmite to fry and see Mars, levigation, cross 170 mesh sieves, obtain fine powder 1 with Chinese liquor; Get Os Pandion haliaeti charred medicinal herb with its property retained, grind into powder, obtain fine powder 2; Get clean Marasmius equicrinis Muell., little fire dries, and is ground into fine powder 3, by fine powder 1,2,3 mix homogeneously;
(3) clean to tylophora florlbunda, Radix Angelicae Pubescentis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Gentianae Macrophyllae and white Rhizoma Curculiginis, step (2) gained mixing fine powders are placed in penetrating bag, together marmite is placed in the Dinodon rufozonatum (Cantor) after step (1) processes, the clear water adding 3 times amount soaks 1 hour, be placed on stove fire, big fire decocts twice, and first time decocts 2-3 hour, second time decocts 1-2 hour, twice medicinal liquid mixing, filters, obtains decocting liquid; Gained decocting liquid is through being condensed into fluid extract;
(4) take the plaster substrate of 2.5 times amount crude drug, after melting with slow fire, be cooled to 65 DEG C, add fluid extract and step (1) gained frankincense powder while stirring, stir;
(5) dip the plaster prepared with bamboo let, spread out on cotton, amount to packaging, put the storage of shady and cool place, obtain external plaster application agent.
The using method of external plaster application agent of the present invention: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 4 days, changes once, within 7 days, is a course for the treatment of.
Model case a: XX, man, 17 years old, master stated: afternoon in April, 2011 and classmate injure right knee joint accidentally when playing football in court, and time medical, the previous day rises, joint swelling and pain, joint stuffiness, and patient is because worrying that school work is reluctant to come hospitalization here and see a doctor.Check: the blue or green stasis of blood of the right knee surface skin of patient, knee joint kneecap has the large lump of goose ovum, pressing pain, knee joint joint stuffiness.
Adopt the present embodiment gained orthopaedics traumatic injury external plaster application agent, after the course for the treatment of, symptom obviously alleviates, and continues to take a course for the treatment of, and the blue or green stasis of blood, pain disappear.Adhere to taking a course for the treatment of, swelling disappears, and activity freely.
embodiment 4orthopaedics traumatic injury external plaster application agent, is prepared from by following raw material, is mass parts: Dinodon rufozonatum (Cantor) 14g, tylophora florlbunda 10g, Olibanum 10g, Radix Angelicae Pubescentis 13g, copper chippings 7g, Os Pandion haliaeti 11g, Marasmius equicrinis Muell. 9g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 11g, Radix Gentianae Macrophyllae 13g, white Rhizoma Curculiginis 8g.
The orthopaedics preparation method of traumatic injury external plaster application agent:
(1) decaptitated by Dinodon rufozonatum (Cantor), remove the peel, clean, cutting, mixes thoroughly with ethanol, slightly vexed, when little fire is fried to surperficial buff, takes out, spreading for cooling; Get Olibanum and add Chinese liquor pouring profit 2.5 hours, be sucked to wine, cure 20 hours with low baking temperature, extremely oil is thoroughly on paper, and matter is crisp, tack-free for spending, and is ground into fine powder and gets final product (every Olibanum block 1kg, Chinese liquor 60g);
(2) get the calcining of copper chippings slow fire, shrend, bits fall, and clean with clear water, enter in marmite to fry and see Mars, levigation, cross 190 mesh sieves, obtain fine powder 1 with Chinese liquor; Get Os Pandion haliaeti charred medicinal herb with its property retained, grind into powder, obtain fine powder 2; Get clean Marasmius equicrinis Muell., little fire dries, and is ground into fine powder 3, by fine powder 1,2,3 mix homogeneously;
(3) clean to tylophora florlbunda, Radix Angelicae Pubescentis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Gentianae Macrophyllae and white Rhizoma Curculiginis, step (2) gained mixing fine powders are placed in penetrating bag, together marmite is placed in the Dinodon rufozonatum (Cantor) after step (1) processes, the clear water adding 3 times amount soaks 2 hours, be placed on stove fire, big fire decocts twice, and first time decocts 2-3 hour, second time decocts 1-2 hour, twice medicinal liquid mixing, filters, obtains decocting liquid; Gained decocting liquid is through being condensed into fluid extract;
(4) take the plaster substrate of 2.5 times amount crude drug, after melting with slow fire, be cooled to 75 DEG C, add fluid extract and step (1) gained frankincense powder while stirring, stir;
(5) dip the plaster prepared with bamboo let, spread out on cotton, amount to packaging, put the storage of shady and cool place, obtain external plaster application agent.
The using method of external plaster application agent of the present invention: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 4 days, changes once, within 7 days, is a course for the treatment of.
Model case: what XX, man, 50 years old, builder.Main to state: in July, 2011, to slip traumatic injury from wooden ladder in an engineering, right open fracture of leg, redness of bleeding, hurt like hell, in hospitalize nearly three months, after leaving hospital, right lower limb was often numb, with swelling, pain, need to lean on to turn and could walk, life can not be taken care of oneself completely.After under the introduction of friend, come here go to a doctor.
Use the present embodiment gained orthopaedics traumatic injury external plaster application agent, after the course for the treatment of, feeling of numbness disappears, and occasionally has hypodynia.Can walk alone after two courses for the treatment of, two courses for the treatment of of continual cure, pain disappears, and can independently normally walk, and life is taken care of oneself completely.
embodiment 5orthopaedics traumatic injury external plaster application agent, is prepared from by following raw material, is mass parts: Dinodon rufozonatum (Cantor) 12g, tylophora florlbunda 8.5g, Olibanum 9g, Radix Angelicae Pubescentis 12g, copper chippings 6g, Os Pandion haliaeti 10g, Marasmius equicrinis Muell. 8g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10g, Radix Gentianae Macrophyllae 12g, white Rhizoma Curculiginis 7.5g.
The orthopaedics preparation method of traumatic injury external plaster application agent:
(1) decaptitated by Dinodon rufozonatum (Cantor), remove the peel, clean, cutting, mixes thoroughly with ethanol, slightly vexed, when little fire is fried to surperficial buff, takes out, spreading for cooling; Get Olibanum and add Chinese liquor pouring profit 2 hours, be sucked to wine, cure 18 hours with low baking temperature, extremely oil is thoroughly on paper, and matter is crisp, tack-free for spending, and is ground into fine powder and gets final product (every Olibanum block 1kg, Chinese liquor 60g);
(2) get the calcining of copper chippings slow fire, shrend, bits fall, and clean with clear water, enter in marmite to fry and see Mars, levigation, cross 180 mesh sieves, obtain fine powder 1 with Chinese liquor; Get Os Pandion haliaeti charred medicinal herb with its property retained, grind into powder, obtain fine powder 2; Get clean Marasmius equicrinis Muell., little fire dries, and is ground into fine powder 3, by fine powder 1,2,3 mix homogeneously;
(3) clean to tylophora florlbunda, Radix Angelicae Pubescentis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Gentianae Macrophyllae and white Rhizoma Curculiginis, step (2) gained mixing fine powders are placed in penetrating bag, together marmite is placed in the Dinodon rufozonatum (Cantor) after step (1) processes, the clear water adding 3 times amount soaks 1.5 hours, be placed on stove fire, big fire decocts twice, and first time decocts 2-3 hour, second time decocts 1-2 hour, twice medicinal liquid mixing, filters, obtains decocting liquid; Gained decocting liquid is through being condensed into fluid extract;
(4) take the plaster substrate of 2.5 times amount crude drug, after melting with slow fire, be cooled to 70 DEG C, add fluid extract and step (1) gained frankincense powder while stirring, stir;
(5) dip the plaster prepared with bamboo let, spread out on cotton, amount to packaging, put the storage of shady and cool place, obtain external plaster application agent.
The using method of external plaster application agent of the present invention: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 4 days, changes once, within 7 days, is a course for the treatment of.
test example 1the clinical practice of traumatic injury external plaster application agent of embodiment 5 gained orthopaedics:
1, physical data
In April ,-2012 in July, 2010, screen 473 routine orthopaedics traumatic injury sufferers in 3 hospitals, wherein man 297 example, female 176 example, max age 54 years old, minimal ages 15 years old, 34.9 years old mean age.All patients are divided into treatment group 300 people and matched group 173 people at random.Two groups of no significant difference (P>0.05) in age and the state of an illness, have comparability.
2, Therapeutic Method
Treatment group takes embodiment 5 gained orthopaedics traumatic injury external plaster application agent, and using method is: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 4 days, changes once, within 7 days, is a course for the treatment of.Treat 3 courses for the treatment of altogether.Matched group adopts other medicine (conventional medication such as pill for traumatic injuries, ZHENGHONGHUA YOU, pseudo-ginseng blood-circulation-invigovating cream).
4, efficacy assessment standard
Recovery from illness: traumatic injury transference cure is movable normal;
Take a turn for the better: traumatic injury symptom is clearly better;
Invalid: traumatic injury symptom has no improvement.
5, therapeutic outcome
Clinical efficacy comparison after two groups of patient treatments, as shown in table 1.
Table 1: take embodiment 5 product 15-54 year traumatic injury patient treatment outcome
Copper chippings eliminating stasis to stop pain in side; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), tylophora florlbunda wind-expelling pain-stopping, promoting blood circulation and detumescence; Olibanum can eliminating stasis to stop pain, eliminating carbuncle of invigorating blood circulation again, and putrefaction-removing granulation-promoting is external wounds key medicine; The all medicines of we share, and can mutually adjust, and strengthen effect of relaxing muscles and tendons to promote blood circulation, removing obstruction in the collateral to relieve pain, promoting blood circulation to remove blood stasis.Therapeutic effect: cure 275 examples (91.7%), 25 examples that take a turn for the better (8.3%), total effective rate 100%.Successful is better than matched group.Through statistical procedures, difference has statistical significance (P<0.05).
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. orthopaedics traumatic injury external plaster application agent, is characterized in that, is prepared from, is mass parts by following raw material: Dinodon rufozonatum (Cantor) 6-18, tylophora florlbunda 5-12, Olibanum 6-12, Radix Angelicae Pubescentis 9-15, copper chippings 4-8, Os Pandion haliaeti 8-12, Marasmius equicrinis Muell. 6-10, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8-12, Radix Gentianae Macrophyllae 9-15, white Rhizoma Curculiginis 6-9.
2. as claimed in claim 1, it is characterized in that, Dinodon rufozonatum (Cantor) 10-14, tylophora florlbunda 7-10, Olibanum 8-10, Radix Angelicae Pubescentis 11-13, copper chippings 5-7, Os Pandion haliaeti 9-11, Marasmius equicrinis Muell. 7-9, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 9-11, Radix Gentianae Macrophyllae 11-13, white Rhizoma Curculiginis 7-8.
3. external plaster application agent as claimed in claim 1, is characterized in that, Dinodon rufozonatum (Cantor) 12, tylophora florlbunda 8.5, Olibanum 9, Radix Angelicae Pubescentis 12, copper chippings 6, Os Pandion haliaeti 10, Marasmius equicrinis Muell. 8, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10, Radix Gentianae Macrophyllae 12, white Rhizoma Curculiginis 7.5.
4., according to the preparation method of the arbitrary described external plaster application agent of claim 1-3, it is characterized in that, step is as follows:
(1) decaptitated by Dinodon rufozonatum (Cantor), remove the peel, clean, cutting, mixes thoroughly with ethanol, slightly vexed, when little fire is fried to surperficial buff, takes out, spreading for cooling; Get Olibanum and add Chinese liquor pouring profit, be sucked to wine, cure with low baking temperature, extremely oil is thoroughly on paper, and matter is crisp, and tack-free is degree, is ground into fine powder and gets final product (every Olibanum block 1kg, Chinese liquor 60g);
(2) get the calcining of copper chippings slow fire, shrend, bits fall, and clean with clear water, enter in marmite to fry and see Mars, levigation, sieve, obtain fine powder 1 with Chinese liquor; Get Os Pandion haliaeti charred medicinal herb with its property retained, grind into powder, obtain fine powder 2; Get clean Marasmius equicrinis Muell., little fire dries, and is ground into fine powder 3, by fine powder 1,2,3 mix homogeneously;
(3) clean to tylophora florlbunda, Radix Angelicae Pubescentis, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Gentianae Macrophyllae and white Rhizoma Curculiginis, step (2) gained mixing fine powders are placed in penetrating bag, together marmite is placed in the Dinodon rufozonatum (Cantor) after step (1) processes, the clear water adding 3 times amount soaks, be placed on stove fire, big fire decocts twice, and first time decocts 2-3 hour, second time decocts 1-2 hour, twice medicinal liquid mixing, filters, obtains decocting liquid; Gained decocting liquid is through being condensed into fluid extract;
(4) take the plaster substrate of 2.5 times amount crude drug, after melting with slow fire, cooling, adds fluid extract and step (1) gained frankincense powder while stirring, stirs;
(5) dip the plaster prepared with bamboo let, spread out on cotton, amount to packaging, put the storage of shady and cool place, obtain external plaster application agent.
5. the preparation method of external plaster application agent according to claim 4, is characterized in that, in step (1), Chinese liquor drenches profit 1-3 hour (preferably drench profit 1.5-2.5 hour, the pouring be more preferably moistens 2 hours).
6. the preparation method of external plaster application agent according to claim 4, is characterized in that, in step (1), low baking temperature cures 12-24 hour (preferably cure 16-20 hour, what be more preferably cures 18 hours).
7. the preparation method of external plaster application agent according to claim 4, is characterized in that, the middle 160-200 mesh sieve excessively of step (2) (preferred 170-190 mesh sieve excessively, mistake 180 mesh sieve be more preferably).
8. the preparation method of external plaster application agent according to claim 4, is characterized in that, in step (3), clear water soak time is 0.5-2.5 hour (preferred soak time is 1-2 hour, and the soak time be more preferably is 1.5 hours).
9. the preparation method of external plaster application agent according to claim 4, is characterized in that, is cooled to 60-80 DEG C (be preferably cooled to 65-75 DEG C, what be more preferably is cooled to 70 DEG C) in step (4).
10. the external plaster application agent as described in as arbitrary in claim 1-3 is preparing the application in orthopaedics traumatic injury medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410568044.4A CN104257931A (en) | 2014-10-23 | 2014-10-23 | Orthopedic traumatic injury external application patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410568044.4A CN104257931A (en) | 2014-10-23 | 2014-10-23 | Orthopedic traumatic injury external application patch and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104257931A true CN104257931A (en) | 2015-01-07 |
Family
ID=52149588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410568044.4A Pending CN104257931A (en) | 2014-10-23 | 2014-10-23 | Orthopedic traumatic injury external application patch and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104257931A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623795A (en) * | 2015-02-03 | 2015-05-20 | 山东省立医院 | External application bag for traumatic orthopedics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007056491A2 (en) * | 2005-11-07 | 2007-05-18 | Jaleva, Llc | Film-forming resins as a carrier for topical application of pharmacologically active agents |
| CN102648929A (en) * | 2012-04-17 | 2012-08-29 | 中国中医科学院中医基础理论研究所 | Chinese medicinal composition for treating osteoarthritis and preparation method thereof |
-
2014
- 2014-10-23 CN CN201410568044.4A patent/CN104257931A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007056491A2 (en) * | 2005-11-07 | 2007-05-18 | Jaleva, Llc | Film-forming resins as a carrier for topical application of pharmacologically active agents |
| CN102648929A (en) * | 2012-04-17 | 2012-08-29 | 中国中医科学院中医基础理论研究所 | Chinese medicinal composition for treating osteoarthritis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王宝红等: "中药薰洗在断指再植术后伤指康复中的应用", 《实用医技杂志》 * |
| 薛红强: "中药熏洗配合按摩治疗躁关节韧带损伤108例", 《陕西中医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623795A (en) * | 2015-02-03 | 2015-05-20 | 山东省立医院 | External application bag for traumatic orthopedics |
| CN104623795B (en) * | 2015-02-03 | 2017-08-25 | 山东省立医院 | A kind of external application bag of orthopaedic trauma |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104644943A (en) | Traditional Chinese medicine composition, medicinal moxibustion containing same and preparation method | |
| CN107468850A (en) | Chinese medicine composition, preparation method and applications and Chinese medicine preparation and preparation method thereof | |
| CN104524530B (en) | A kind of Chinese medicine composition and its application in the medicine for preparing treatment arthralgia and myalgia | |
| CN1322885C (en) | Plaster medicine composition with multiple purpose for treating affection pain due to dampness | |
| CN102895365B (en) | External ointment for treating bone injury and orthopedics inflammation | |
| CN104258278A (en) | Gushangling (for bone injury) spray | |
| CN1132616C (en) | Traditional Chinese medicine for treating arthralgia-syndrome | |
| CN108498617A (en) | Rheumatalgia Chinese medicine composition and its preparation method and application, lavipeditum packet and preparation method thereof and pharmaceutical preparation | |
| CN103977367A (en) | Traditional Chinese medicament for treating qi-stagnation blood-aggregation type bedsore and preparation method thereof | |
| CN108310070A (en) | A kind of Chinese medicine composition and preparation method thereof for treating pain | |
| CN103340972B (en) | Traditional Chinese medicine composition for treating traumatic injuries | |
| CN107823280A (en) | A kind of Chinese medicine composition for treating pain and preparation method thereof | |
| CN104257931A (en) | Orthopedic traumatic injury external application patch and preparation method thereof | |
| CN105561272A (en) | Traditional Chinese medicine preparation for relieving Reynolds disease and preparation method thereof | |
| CN110538272A (en) | swelling-reducing and collateral-dredging powder for treating soft tissue injury and joint swelling and pain and preparation method thereof | |
| CN104274785A (en) | Traditional Chinese medicine preparation for hand tendon injuries and preparation method thereof | |
| CN103127349B (en) | Medicine for treating traumatic injury | |
| CN104474372B (en) | A kind of pill and preparation method for fracture surgery rehabilitation medical | |
| CN102038928A (en) | Traditional Chinese medicine for treating acute and chronic urticaria and dermatosis | |
| CN105687424A (en) | Ointment for treating traumatic injuries | |
| CN105497817A (en) | Chinese herbal preparation for treating turgescence caused by trauma of ankle joint and preparation method thereof | |
| CN106619852A (en) | Traditional Chinese medicine lavipeditum life cultivation and health preservation prescription with effects of warming channels and dispersing cold, and dredging grain of skin and texture of the subcutaneous flesh | |
| CN105617214A (en) | Traditional Chinese medicine composition for treating scabies | |
| CN104606642A (en) | Gel for treating traumatic injury and preparation method of gel | |
| CN105362944A (en) | Traditional Chinese medicine ointment for treating orthopedics sprain and contusion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 352000 children's Palace Road, Jiaocheng District, Fujian, Ningde, No. Applicant after: Zhang Xiangcai Address before: 250000, Licheng District, Licheng District, Shandong, Ji'nan Applicant before: Zhang Xiangcai |
|
| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150107 |
|
| RJ01 | Rejection of invention patent application after publication |