CN102688182A - Vagina pH buffer antibacterial gel and preparation method thereof - Google Patents
Vagina pH buffer antibacterial gel and preparation method thereof Download PDFInfo
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- CN102688182A CN102688182A CN2012101807841A CN201210180784A CN102688182A CN 102688182 A CN102688182 A CN 102688182A CN 2012101807841 A CN2012101807841 A CN 2012101807841A CN 201210180784 A CN201210180784 A CN 201210180784A CN 102688182 A CN102688182 A CN 102688182A
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- gel
- vagina
- chitosan
- polycarbophil
- antibacterial
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 239000006174 pH buffer Substances 0.000 title abstract description 3
- 238000001879 gelation Methods 0.000 title description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
- 229920001661 Chitosan Polymers 0.000 claims abstract description 30
- 229920000148 Polycarbophil calcium Polymers 0.000 claims abstract description 21
- 229950005134 polycarbophil Drugs 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 229960001631 carbomer Drugs 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000008367 deionised water Substances 0.000 claims abstract description 6
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 20
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- 230000008569 process Effects 0.000 claims description 7
- 238000007599 discharging Methods 0.000 claims description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
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- 239000000427 antigen Substances 0.000 abstract description 2
- 102000036639 antigens Human genes 0.000 abstract description 2
- 108091007433 antigens Proteins 0.000 abstract description 2
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
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- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 8
- 231100000321 erythema Toxicity 0.000 description 8
- 230000036783 anaphylactic response Effects 0.000 description 7
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- 241000700199 Cavia porcellus Species 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 6
- 206010046914 Vaginal infection Diseases 0.000 description 6
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000195622 Astasia Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 206010010947 Coordination abnormal Diseases 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
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- VYZAHLCBVHPDDF-UHFFFAOYSA-N Dinitrochlorobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 VYZAHLCBVHPDDF-UHFFFAOYSA-N 0.000 description 1
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- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 1
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- 239000006053 animal diet Substances 0.000 description 1
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- 239000000227 bioadhesive Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- 239000006210 lotion Substances 0.000 description 1
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- 230000000474 nursing effect Effects 0.000 description 1
- 229940127249 oral antibiotic Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
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CN2012101807841A CN102688182B (en) | 2012-06-04 | 2012-06-04 | Vagina pH buffer antibacterial gel and preparation method thereof |
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CN2012101807841A CN102688182B (en) | 2012-06-04 | 2012-06-04 | Vagina pH buffer antibacterial gel and preparation method thereof |
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CN102688182A true CN102688182A (en) | 2012-09-26 |
CN102688182B CN102688182B (en) | 2013-11-27 |
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CN2012101807841A Expired - Fee Related CN102688182B (en) | 2012-06-04 | 2012-06-04 | Vagina pH buffer antibacterial gel and preparation method thereof |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103908479A (en) * | 2014-04-29 | 2014-07-09 | 安徽徽科生物工程技术有限公司 | Medical hydrogel for treating gynecological diseases or skin diseases and application of medical hydrogel |
CN105362289A (en) * | 2015-10-24 | 2016-03-02 | 惠峪 | Vagina-retained boric acid preparation and preparation method thereof |
CN105919926A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Carbomer cervical gel and preparation method thereof |
CN106265486A (en) * | 2016-08-18 | 2017-01-04 | 滨州医学院附属医院 | A kind of miconazole nitrate sustained-release gel and preparation method thereof |
CN106540046A (en) * | 2016-12-21 | 2017-03-29 | 甘起伍 | A kind of vagina antibiosis pharmaceutical gel |
CN109793706A (en) * | 2019-03-20 | 2019-05-24 | 吉林省盛赛医药实业有限公司 | A kind of gynecological gel and preparation method thereof with carboxyl double ion biology crosslinking technological |
CN110575431A (en) * | 2019-08-28 | 2019-12-17 | 南京天朗制药有限公司 | Vaginal acid-base buffer gel and preparation method thereof |
CN112933109A (en) * | 2021-02-03 | 2021-06-11 | 湖南奥朗特医疗器械有限公司 | Vagina pH regulator and preparation method and application thereof |
CN114230808A (en) * | 2021-12-20 | 2022-03-25 | 中国科学院重庆绿色智能技术研究院 | Preparation method of antibacterial gel with amino polyethylene glycol as gel matrix |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6017521A (en) * | 1989-10-31 | 2000-01-25 | Columbia Laboratories, Inc. | Use of polycarboxylic acid polymers to treat vaginal infections |
US20010031251A1 (en) * | 1999-12-22 | 2001-10-18 | Columbia Laboratories, Inc. | Vaginal pH Buffering for preventing miscarriage and premature labor, and for treating or preventing bacterial vaginosis |
KR20040028336A (en) * | 2002-09-30 | 2004-04-03 | 김종국 | Novel composite of thermosensitive antifungal gel for vaginal administration |
CN1823813A (en) * | 2005-12-08 | 2006-08-30 | 吴奕光 | Nursing and treating composition for female vagina and its preparation method |
CN101773516A (en) * | 2009-11-26 | 2010-07-14 | 上海华拓医药科技发展股份有限公司 | Acidic buffer gel preparation for vaginas and preparation method and application thereof |
CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
-
2012
- 2012-06-04 CN CN2012101807841A patent/CN102688182B/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6017521A (en) * | 1989-10-31 | 2000-01-25 | Columbia Laboratories, Inc. | Use of polycarboxylic acid polymers to treat vaginal infections |
US20010031251A1 (en) * | 1999-12-22 | 2001-10-18 | Columbia Laboratories, Inc. | Vaginal pH Buffering for preventing miscarriage and premature labor, and for treating or preventing bacterial vaginosis |
KR20040028336A (en) * | 2002-09-30 | 2004-04-03 | 김종국 | Novel composite of thermosensitive antifungal gel for vaginal administration |
CN1823813A (en) * | 2005-12-08 | 2006-08-30 | 吴奕光 | Nursing and treating composition for female vagina and its preparation method |
CN101773516A (en) * | 2009-11-26 | 2010-07-14 | 上海华拓医药科技发展股份有限公司 | Acidic buffer gel preparation for vaginas and preparation method and application thereof |
CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103908479A (en) * | 2014-04-29 | 2014-07-09 | 安徽徽科生物工程技术有限公司 | Medical hydrogel for treating gynecological diseases or skin diseases and application of medical hydrogel |
CN103908479B (en) * | 2014-04-29 | 2017-06-06 | 安徽徽科生物工程技术有限公司 | For treating gynecological disease or dermopathic medical aquogel and its application |
CN105362289B (en) * | 2015-10-24 | 2018-08-31 | 惠峪 | A kind of vaginal retention borate compounds and preparation method thereof |
CN105362289A (en) * | 2015-10-24 | 2016-03-02 | 惠峪 | Vagina-retained boric acid preparation and preparation method thereof |
CN105919926A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Carbomer cervical gel and preparation method thereof |
CN105919926B (en) * | 2016-06-29 | 2019-11-05 | 江苏开源康达医疗器械有限公司 | A kind of Carbomer cervical gel and preparation method thereof |
CN106265486A (en) * | 2016-08-18 | 2017-01-04 | 滨州医学院附属医院 | A kind of miconazole nitrate sustained-release gel and preparation method thereof |
CN106540046A (en) * | 2016-12-21 | 2017-03-29 | 甘起伍 | A kind of vagina antibiosis pharmaceutical gel |
CN109793706A (en) * | 2019-03-20 | 2019-05-24 | 吉林省盛赛医药实业有限公司 | A kind of gynecological gel and preparation method thereof with carboxyl double ion biology crosslinking technological |
CN110575431A (en) * | 2019-08-28 | 2019-12-17 | 南京天朗制药有限公司 | Vaginal acid-base buffer gel and preparation method thereof |
WO2021036294A1 (en) * | 2019-08-28 | 2021-03-04 | 南京天朗制药有限公司 | Vaginal acid-base buffer gel and preparation method |
CN110575431B (en) * | 2019-08-28 | 2021-08-03 | 南京天朗制药有限公司 | Vaginal acid-base buffer gel and preparation method thereof |
CN112933109A (en) * | 2021-02-03 | 2021-06-11 | 湖南奥朗特医疗器械有限公司 | Vagina pH regulator and preparation method and application thereof |
CN114230808A (en) * | 2021-12-20 | 2022-03-25 | 中国科学院重庆绿色智能技术研究院 | Preparation method of antibacterial gel with amino polyethylene glycol as gel matrix |
CN114230808B (en) * | 2021-12-20 | 2024-04-16 | 中国科学院重庆绿色智能技术研究院 | Preparation method of antibacterial gel with amino polyethylene glycol as gel matrix |
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Publication number | Publication date |
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CN102688182B (en) | 2013-11-27 |
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