CN104257684A - Medicated bath liniment for cow nipples and preparation method of medicated bath liniment - Google Patents
Medicated bath liniment for cow nipples and preparation method of medicated bath liniment Download PDFInfo
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- CN104257684A CN104257684A CN201410507531.XA CN201410507531A CN104257684A CN 104257684 A CN104257684 A CN 104257684A CN 201410507531 A CN201410507531 A CN 201410507531A CN 104257684 A CN104257684 A CN 104257684A
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Abstract
The invention discloses a medicated bath liniment for cow nipples for preventing cow mastitis, and a preparation method of the medicated bath liniment. The medicated bath liniment is prepared from more than ten raw materials such as a film-forming agent. The medicated bath liniment has the advantages on the following three aspects: 1, the film-forming agent is added to medicated bath liquor, so that a protective screen is formed between each nipple and the environment; 2 a skin care agent is added to the medicated bath liquor, so as to protect the skin of the nipples; and 3 sterilization, film formation and skin care are organically combined, so that the functions of a medicated bath disinfector for the nipples are achieved, the nipples are protected in an omnibearing manner, and the cow mastitis is very effectively prevented.
Description
Technical field
The present invention relates to a kind of for preventing the nipple dipping liniment of bovine mastitis, the invention still further relates to a kind of preparation method of this nipple dipping liniment.
Background technology
Bovine mastitis is one of common, the most multiple disease during milk cattle cultivating is produced, and primarily of cause pathogeny imcrobe infection, causes mammary gland tissue to produce pathological change, causes a kind of inflammatory reaction of dysgalactia.The sickness rate of bovine mastitis reaches 20% ~ 60% at present according to statistics, and indivedual cows sickness rate is even higher.During milch cow generation mastitis, milk yield reduces, and delay to oestrus and breed, the serious milking capacity that loses is eliminated in advance, and it is serious to add the economic losses such as discarded milk and medical expense.
Because bovine mastitis pathogenic factor is extremely complicated, only infective pathogen microorganism just has kind more than 150, and encountered pathogenic is kind more than 20, adds the factor such as strain variation and drug resistance, cause and be difficult to filter out efficient medicine rapidly and accurately, thus to make a definite diagnosis and treatment brings very large difficulty.In recent years, more general with antibiotic therapy, but the use of long-term, high-dose causes bacterial resistance sex chromosome mosaicism, people eat in disease Lac Bovis seu Bubali juice containing a large amount of pathogenic microorganism and toxin thereof or after treatment a large amount of antibiotic remains cause the symptoms such as fever, vomiting, allergy day by day seriously, harm humans health; Other Therapeutic Method is as also undesirable in Chinese herbal medicine, biotherapy effect, can not tackle the problem at its root.
Suffer from cattle at mastitis, about have the case of more than 90% be by exogenous pathogenic microorganism through the nipple mammary gland mouth of pipe, enter mammary gland tissue and cause morbidity.Therefore, kill Supramammillary pathogenic microorganism, stop pathogenic microorganism to invade, be prevent bovine mastitis from occurring the most simply, the most direct, most effectual way.Nipple dipping is method conventional at present, in China, an important step in Cow product process has been included in nipple dipping in, it is the major part of milk cow milking operation sequence, nipple dipping must be carried out after milk cow milking, therefore, nipple dipping disinfectant is that Cow product is required, and use amount is very huge.Dipping disinfectant conventional clinically at present has hibitane, potassium permanganate, iodophors, sodium hypochlorite etc., these are all water-soluble antiseptic agent, the antibacterial that can reduce the bacterial number on skin of nipple or can eliminate at short notice on skin of nipple, prevents the generation of bovine mastitis to a certain extent.But its sterilization speed is slow, and sterilizing power is held time short, have also appeared a lot of problem, and such as, to stimulation or the corrosivity of skin of nipple, life-time service can cause xerosis cutis, causes skin of nipple to chap; At arctic weather, nipple soaks and easily to freeze and frosted teat afterwards; Drug residue etc.Therefore, these traditional nipple dipping disinfectant have been not suitable with modern milk cattle cultivating needs, and simple dipping disinfectant can not prevent mastitis to occur effectively.
The present invention is on the basis of my invention's " film forming agent for milk cow nipple protection film and preparation method thereof ", to carry out preferably to filmogen, then disinfectant and skin protectant is added, add activation simultaneously, the adjuvant of Stable Iodine effect, be prepared into milk cow nipple medicated bath liniment, there is film forming, the functions such as sterilization and skin moistening, increase nipple dipping effect, be more suitable for and meet the needs of nipple dipping, layer protecting film can be formed rapidly on nipple surface, wrap nipple, close the nipple mouth of pipe, thorough blocking-up pathogenic microorganism invades mammary gland tissue by the nipple mouth of pipe, Supramammillary pathogen can be killed fast again, caring effect can be played again to skin of nipple, prevent from chapping and cold injury.Compared with the dipping medicine that other are traditional, more fully protect papilla of breast, effectively prevent the generation of bovine mastitis.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of for preventing the nipple dipping liniment of bovine mastitis, and the another one technical problem that the present invention will solve is the preparation method providing this nipple dipping liniment a kind of.
Product nipple dipping liniment of the present invention be by following active drug component and and percetage by weight proportioning be prepared from:
Film former by weight ratio be 1: 3 PVA and the polyvinyl alcohol 17-50 distilled water that adds 18 times be respectively mixed, disinfectant is povidone iodine, and it is formulated that skin-care agent is etc. that the water solublity lanoline of weight and hydrophilic glycerin add the distilled water of 3 times.
In above-mentioned raw materials: film former has filming function, nontoxic to skin of nipple, non-stimulated, stable performance, do not reduce principal agent drug effect, do not disturb assay, without uncomfortable stink, there are enough intensity and pliability after film forming, there is good water solublity, the feature such as to degrade gradually; Disinfectant has kills Supramammillary pathogenic microorganism effect; Skin-care agent has moisturizing to skin, moistens effect.By science selection, rational formula, on film-forming base, add disinfectant, skin-care agent and adjuvant, the medicinal liquid character of preparation is stable, safe and reliable, can not only kill Supramammillary pathogenic microorganism, and have good filming performance, wrap nipple, prevent pathogen from invading from nipple mouth, can also moisten skin of nipple, nursing nipple prevents dry and chaps.In above-mentioned raw materials except povidone iodine low toxicity, other composition to milch cow and human body all nontoxic, harmless, have no side effect, the liniment of preparation can be used safely, on milch cow and milk thereof without any impact.
Below the preparation method of product of the present invention:
(1) film former: the distilled water immersion 24 hours PVA and polyvinyl alcohol 17-50 being added respectively 18 times, 96 DEG C of heating in water bath 2.5 hours, and constantly stir, make it fully dissolve, filter and remove foreign material, dry in the air cool, by two kinds of solution in 1: 3 ratio mixing.
(2) disinfectant: distilled water povidone iodine being added 12 times, fully stirs, closes, keeps in Dark Place to all dissolving, filter and remove foreign material.
(3) skin-care agent: water solublity lanoline and hydrophilic glycerin 1: 1 are mixed, add the distilled water of 3 times, mixing, fully stirs, and filters and removes foreign material.
(4) by above-mentioned three kinds of solution mixing, add extraordinary ether ester compound respectively, polyoxyethylene fatty glyceride ester, sodium tripolyphosphate, sorbitol, fabaceous lecithin, pulullan, methylcellulose fully stir, then add the distilled water of surplus.
Filmogen plays styling, and the present invention selects pharmaceutical grade Polyethylene alcohol, is mainly used in people's medicine adjuvant, nontoxic, low price, easy to use; The PVA degree of polymerization selected is less, water solublity is comparatively large, pliability is poor, the polyvinyl alcohol 17-50 degree of polymerization is comparatively large, water solublity is less, pliability is better, both solution are mixed in 1: 3 ratio, makes that the film tensile strength of formation is large, pliability good, film forming is fast, performance is good.The present invention smears nipple immediately after milk cow milking, can form rapidly one deck protection book film, be wrapped in nipple surface, between nipple and environmental bacteria, form barrier, stop pathogenic microorganism to invade mammary gland tissue by the nipple mouth of pipe on nipple surface.
Povidone iodine cures wide clinical application people, it is one of best at present disinfectant, sterilization speed is fast, fungicidal spectrum is wide, efficient, low toxicity, safety, for antibacterial, fungus, virus, protozoon etc., all there is good killing action, it not only kills the pathogenic microorganism on skin of nipple, and solution can be made to be preserved for a long time, safe and reliable.
In order to make cow papillary skin protected, the water solublity lanoline good hydrophilic property of selection, has good skin moistening and conditioning performance, can alleviate the dry of skin and can improve skin elasticity; Hydrophilic glycerin is soluble in water, has very strong hygroscopicity, absorbs the moisture content in air, makes skin keep moistening and soft, high resilience, not dry by the infringement such as dust, weather, plays the effect preventing skin frostbite.Both are mixed by a certain percentage, stronger, better to the protective effect of skin.
Advantage of the present invention has three aspects, and first is add film former in dip, between nipple and environment, form barrier.Second is add skin protectant in dip, protection skin of nipple.3rd is sterilization, film forming and skin protection are organically combined, and increase the function of nipple dipping disinfectant, omnibearing protection nipple, more effectively prevents the generation of bovine mastitis.
Detailed description of the invention
Embodiment 1
Product milk cow nipple medicated bath liniment of the present invention is prepared from by following active drug component and percetage by weight proportioning:
Embodiment 2
Product milk cow nipple medicated bath liniment of the present invention is prepared from by following active drug component and percetage by weight proportioning:
Embodiment 3
Product milk cow nipple medicated bath liniment of the present invention is prepared from by following active drug component and percetage by weight proportioning:
Embodiment 4
Product milk cow nipple medicated bath liniment of the present invention is prepared from by following active drug component and percetage by weight proportioning:
Embodiment 5
Product milk cow nipple medicated bath liniment of the present invention is prepared from by following active drug component and percetage by weight proportioning:
Embodiment 6
Below the preparation method of product of the present invention:
(1) film former: the distilled water immersion 24 hours PVA and polyvinyl alcohol 17-50 being added respectively 18 times, 96 DEG C of heating in water bath 2.5 hours, and constantly stir, make it fully dissolve, filter and remove foreign material, dry in the air cool, by two kinds of solution in 1: 3 ratio mixing.
(2) disinfectant: distilled water povidone iodine being added 12 times, fully stirs, closes, keeps in Dark Place to all dissolving, filter and remove foreign material.
(3) skin-care agent: water solublity lanoline and hydrophilic glycerin 1: 1 are mixed, add the distilled water of 3 times, mixing, fully stirs, and filters and removes foreign material.
(4) by above-mentioned three kinds of solution mixing, add extraordinary ether ester compound respectively, polyoxyethylene fatty glyceride ester, sodium tripolyphosphate, sorbitol, fabaceous lecithin, pulullan, methylcellulose fully stir, then add the distilled water of surplus.
Embodiment 7
The using method of product of the present invention:
Smear nipple with said preparation after milk cow milking, with water or wet towel one wiping before milking next time, namely film can come off.
Embodiment 8
The quality testing of product of the present invention and effect assessment:
1, character
This product is tasteless, light brown, translucent, clarification, slightly glutinous thick liquid.
2, pH value
Get 4ml solution in penicillin bottle, measure with the pH instrument demarcated, after stable reading, read result and record.Solution ph is 5.3.
3, available iodine content
Get 5ml solution and be placed in beaker, add water to 50ml, use 0.01M Na
2s
2o
3when volumetric solution titration sample solution is to nearly terminal, add 2ml5% starch indicator, continue to be titrated to blue disappearance, the Na consumed during record titration end-point
2s
2o
3volumetric solution volume, calculates the available iodine content (1ml0.01M sodium thiosulfate is equivalent to 1.269mg available iodine) of solution.Solution available iodine content is 0.78mg/ml.
4, film formation time test
Smear mammilla of milk cattle with milk cow nipple medicated bath liniment, observe its film formation time, film-forming state, result, when 90s, nipple just can form a skim.Film is slowly opened, stronger, complete, in blocks, the imperforate protecting film of the film elasticity of formation.
5, stability test
Getting the milk cow nipple medicated bath liniment prepared is sub-packed in the vial of 500ml, stores, every 7d routine observation respectively at room temperature lucifuge and refrigerator (0 DEG C ~ 5 DEG C).In 12 months as a result, nothing precipitates, without layering, without metachromatism.
6, irritation test
1. once smear test: get healthy adult rabbit 10, average weight is 2.2 ± 0.2kg, and male and female are not limit, shave light man rabbit back diamond wool and be about 8cm
2, get nipple dipping liniment and each 2ml of ordinary water, what be evenly coated in a rabbit back both sides respectively shaves hair place, in administration 1,2,4,6,12,24,48, observe dermoreaction after 72h.Result spreader portion is all reacted without the skin abnormality such as erythema, vesicle.
2. smear test continuously: get other healthy adult rabbit 10, average weight is 2.2 ± 0.2kg, and male and female are not limit, shave light man rabbit back diamond wool and be about 8cm
2, get nipple dipping liniment and each 2ml of ordinary water, every day 3 times, every minor tick is roughly identical with the milk cow milking time, and shave hair place respectively at what be evenly coated in a rabbit back both sides, continuous 7d observes dermoreaction.Result spreader portion is all reacted without the skin abnormality such as erythema, vesicle.
7, stripping test
Nipple dipping liniment is smeared mammilla of milk cattle, cleans by milk cow milking operation sequence warm water after film forming, once washing after the film chance water that result is formed, without individual processing.
8, hygiene inspection
1. cultivate inspection: add on broth medium and agar culture medium respectively by nipple dipping liniment, after placing 37 DEG C of calorstat 24h, observe the change of culture medium.All without bacterial growth in result broth medium and on agar culture medium.
2. routine preservation inspection: be sub-packed in the vial of 500ml by nipple dipping liniment and seal, lucifuge is placed at normal temperatures, observes once every 1 month.Generate without microorganisms such as any antibacterial, funguses in solution in 24 months as a result, solution never degenerates.
9, fungicidal effectiveness inspection
1. bacteriostatic test: the staphylococcus aureus be separated from mammitis of cow pathological material of disease, streptococcus agalactiae, streptococcus dysgalactiae and escherichia coli are inoculated on medium agar flat board suitable separately, often kind of antibacterial Simultaneous vaccination 2 culture medium, then I, II is divided two groups, often organize 4 kinds of different culture medium, I group adds thin layer nipple dipping liniment, II group does not add nipple dipping liniment, places 37 DEG C of calorstats, observes the growing state of antibacterial after cultivating 24h.
The results are shown in Table 1.
Table 1 bacteriostatic test
Result adds the group of thin layer nipple dipping liniment, and without bacterial growth in each culture medium, do not add the group of nipple dipping liniment, in each culture medium, bacterial growth is normal.
2. bactericidal assay: the staphylococcus aureus be separated from mammitis of cow pathological material of disease, streptococcus agalactiae, streptococcus dysgalactiae and escherichia coli are inoculated on suitable medium agar flat board, often kind of antibacterial Simultaneous vaccination 2 culture medium, place after 24h cultivated by 37 DEG C of calorstats and divide I, II two groups, often organize 4 kinds of different culture medium, I group adds thin layer nipple dipping liniment, II group does not add nipple dipping liniment, then places 37 DEG C of calorstats continuation cultivations, observes bacterial growth situation after 24h.
The results are shown in Table 2.
Table 2 bactericidal assay
After result adds nipple dipping liniment, bacterium colony stops growing, dead, does not add in the culture medium of nipple dipping liniment, has bacterial growth.
10, clinical application effect test
1. test sky, milch cow Heilongjiang Province and animal husbandry company, kind is china holstein cows.Select 3 ~ 5 years old, the calving milch cow of 2 ~ 4 months 156, conventional to raise, personal management, feed essence is slightly arranged in pairs or groups, and drylot feeding combines with herding, and mechanization is milked, three times on the one, weekly regularly sterilization 2 times.
2. test drug povidone iodine, Wanda's sanitizer factory of Qiqihaer City produces, product batch number: 20120512; Milk cow nipple medicated bath liniment, the development and production of this institute, product batch number: 20120518.
3. test method when raising, environment, personal management, to milk etc. identical, test milch cow stochastic averagina is divided into three groups, and often organize 52, I group is matched group, milk front and back warm water scouring breast and nipple, need not any sterilization drugs; II group cleans breast and nipple, front and back povidone iodine dipping nipple of milking with warm water before milking; III group cleans breast and nipple with warm water before milking, and soaks nipple after milking with milk cow nipple medicated bath liniment.Test was from 21 days Mays in 2012, to end of day August 26 in 2012,7 days preliminary trial periods, experimental period is 90d, examine the state of cow breast every day, check Lac Bovis seu Bubali once by sodium lauryl sulphate rennet test method weekly, detect the incidence of bovine mastitis, and evaluate the effect of milk cow nipple medicated bath liniment prevention bovine mastitis.To the isolation of mastitis morbidity cattle, clearance test cows, treat in time.
4. the results are shown in Table 3.
Table 3 milk cow nipple medicated bath liniment clinical application effect is tested
I group bovine mastitis sickness rate is 46.15%, II group bovine mastitis sickness rate to be 17.31%, III group bovine mastitis sickness rate be 7.69%, III group bovine mastitis sickness rate than I group reduction by 38.46%, than II group reduction by 9.62%.The cow papillary skin of application milk cow nipple medicated bath liniment is moistening, soft, without breach.Result of the test shows: milk cow nipple medicated bath liniment has effect preferably, is obviously better than povidone iodine, effectively can prevent the generation of bovine mastitis.
Claims (2)
1. for preventing a nipple dipping liniment for bovine mastitis, this nipple dipping liniment be by following active drug component and and percetage by weight proportioning be prepared from:
Film former 60 ~ 70% disinfectant 10 ~ 15% skin-care agent 10 ~ 15%
Extraordinary ether ester compound 0.2 ~ 0.5% fabaceous lecithin 1 ~ 1.5% sorbitol 0.4 ~ 0.7%
Sodium tripolyphosphate 0.1 ~ 0.3% pulullan 0.2 ~ 0.5% methylcellulose 0.5 ~ 0.8%
Polyoxyethylene fatty glyceride ester 0.1 ~ 0.3% distilled water to 100%,
Film former by weight ratio be 1: 3 PVA and the polyvinyl alcohol 17-50 distilled water that adds 18 times be respectively mixed, disinfectant is povidone iodine, and it is formulated that skin-care agent is etc. that the water solublity lanoline of weight and hydrophilic glycerin add the distilled water of 3 times.
2. the method prepared as claimed in claim 1 for the nipple dipping liniment preventing bovine mastitis is as follows:
(1) film former: the distilled water immersion 24 hours PVA and polyvinyl alcohol 17-50 being added respectively 18 times, 96 DEG C of heating in water bath 2.5 hours, and constantly stir, make it fully dissolve, filter and remove foreign material, dry in the air cool, by two kinds of solution in 1: 3 ratio mixing;
(2) disinfectant: distilled water povidone iodine being added 12 times, fully stirs, closes, keeps in Dark Place to all dissolving, filter and remove foreign material;
(3) skin-care agent: water solublity lanoline and hydrophilic glycerin 1: 1 are mixed, add the distilled water of 3 times, mixing, fully stirs, and filters and removes foreign material;
(4) by above-mentioned three kinds of solution mixing, add extraordinary ether ester compound respectively, polyoxyethylene fatty glyceride ester, sodium tripolyphosphate, sorbitol, fabaceous lecithin, pulullan, methylcellulose fully stir, then add the distilled water of surplus.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622792A (en) * | 2015-03-04 | 2015-05-20 | 扬州大学 | Film-forming papilla medicated bath preparation used for controlling recessive mastitis of dairy cattle |
| CN105168239A (en) * | 2015-09-07 | 2015-12-23 | 山东大学 | Breast protection membrane for preventing dairy cow mastitis and preparing process of breast protection membrane |
| CN106138091A (en) * | 2016-08-24 | 2016-11-23 | 四川恒通动物制药有限公司 | A kind of pharmaceutical composition preventing and treating bovine mastitis and preparation method thereof |
| CN112870218A (en) * | 2021-01-27 | 2021-06-01 | 山东中农普宁药业有限公司 | Mixture for the treatment of Staphylococcus aureus mastitis |
| CN113456616A (en) * | 2021-07-09 | 2021-10-01 | 潮州市亿生健医药保健品有限公司 | Polyhexamethylene guanidine-based film coating agent for disinfection and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622792A (en) * | 2015-03-04 | 2015-05-20 | 扬州大学 | Film-forming papilla medicated bath preparation used for controlling recessive mastitis of dairy cattle |
| CN105168239A (en) * | 2015-09-07 | 2015-12-23 | 山东大学 | Breast protection membrane for preventing dairy cow mastitis and preparing process of breast protection membrane |
| CN106138091A (en) * | 2016-08-24 | 2016-11-23 | 四川恒通动物制药有限公司 | A kind of pharmaceutical composition preventing and treating bovine mastitis and preparation method thereof |
| CN112870218A (en) * | 2021-01-27 | 2021-06-01 | 山东中农普宁药业有限公司 | Mixture for the treatment of Staphylococcus aureus mastitis |
| CN113456616A (en) * | 2021-07-09 | 2021-10-01 | 潮州市亿生健医药保健品有限公司 | Polyhexamethylene guanidine-based film coating agent for disinfection and preparation method thereof |
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Inventor after: Zhou Qingmin Inventor after: Feng Wanyu Inventor before: Zhou Qingmin Inventor before: Xu Xin Inventor before: Hou Meiru Inventor before: Feng Wanyu |
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Effective date of registration: 20220110 Address after: Heping Village, chenggaozi Town, Xiangfang District, Harbin City, Heilongjiang Province Patentee after: HARBIN LU DA SHENG ANIMAL PHARMACEUTICAL Co.,Ltd. Address before: 161006 provincial Veterinary Institute, No. 112, xierdao street, Jianhua District, Qiqihar City, Heilongjiang Province Patentee before: HEILONGJIANG INSTITUTE OF VETERINARY SCIENCE |