CN114652767A - Medicated bath agent for nipples of dairy cows and preparation method thereof - Google Patents
Medicated bath agent for nipples of dairy cows and preparation method thereof Download PDFInfo
- Publication number
- CN114652767A CN114652767A CN202210463462.1A CN202210463462A CN114652767A CN 114652767 A CN114652767 A CN 114652767A CN 202210463462 A CN202210463462 A CN 202210463462A CN 114652767 A CN114652767 A CN 114652767A
- Authority
- CN
- China
- Prior art keywords
- parts
- agent
- cow
- sodium chlorite
- medicated bath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of cow mastitis, in particular to a cow nipple medicated bath agent and a preparation method thereof, wherein the medicated bath agent is prepared from the following raw materials in parts by weight: 0.5-6 parts of composite sodium chlorite effervescent tablets, 1-20 parts of film forming agent, 0.6-5 parts of plasticizer, 1-6 parts of surfactant, 0.5-3 parts of skin care agent, 6-8 parts of analgesic and bacteriostatic agent, 0.6-3 parts of thickening agent, 1-5 parts of nano titanium dioxide powder and 550-650 parts of distilled water. The cow nipple medicated bath agent provided by the invention has small irritation to cow breasts and nipple skins, can be used for efficiently sterilizing the cow nipple parts, can be used for protecting damaged or swollen parts and accelerating wound healing, and has the advantages of high efficiency, stability, safety, durability, good air permeability and good moisturizing effect.
Description
Technical Field
The invention relates to the technical field of cow mastitis, in particular to a cow nipple medicated bath agent and a preparation method thereof.
Background
Cow mastitis is caused by infection of various pathogenic microorganisms, and is one of the most common diseases in cow production and causes the largest economic loss. When people eat the milk produced by dairy cows with mastitis, the symptoms of diarrhea, vomiting, fever and the like can be caused. Therefore, the method has great significance in production practice for strengthening the prevention and treatment of cow mastitis, especially recessive mastitis.
The types of the cow nipple medicated bath liquid on the market at present are various, and the clinical commonly used medicated bath liquid comprises iodine preparations, guanidines, peroxides, quaternary ammonium salts and traditional Chinese medicines. However, the iodine preparation type medicinal bath liquid has some defects that the water content of the iodine preparation type medicinal bath liquid exceeds 90 percent, the nipple of a cow is easy to freeze and the nipple is frosted when the iodine preparation type medicinal bath liquid is used in cold climates, the cow is eliminated in advance, and the iodine preparation type medicinal bath liquid has certain stimulation effect on the skin of the cow, can cause the skin allergy of the cow, and can also cause the iodine content of a milk product to exceed the standard after long-term use; the guanidine bath lotion has certain stimulation to the skin and has poor killing effect on virus spores and the like; peroxide type medicinal bath liquid needs to be operated strictly according to the instructions or harm can be generated; the quaternary ammonium salt type medicinal bath liquid has poor sterilization effect and certain irritation to skin, and is easy to cause skin chap of dairy cows; the traditional Chinese medicine bath liquid has long treatment course and slow effect.
Disclosure of Invention
In view of the above, the invention provides a medicated bath agent for cow nipples and a preparation method thereof, the medicated bath agent for cow nipples provided by the invention has small irritation to the cow breast and nipple skin, can be used for efficiently sterilizing the cow nipple part, can be used for protecting the damaged or swollen part and accelerating wound healing, has the advantages of high efficiency, stability, safety, durability, good air permeability and good moisturizing effect, and overcomes the defects of the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a medicated bath agent for nipples of dairy cows, which is prepared from the following raw materials in parts by weight: 0.5-6 parts of composite sodium chlorite effervescent tablets, 1-20 parts of film forming agent, 0.6-5 parts of plasticizer, 1-6 parts of surfactant, 0.5-3 parts of skin care agent, 6-8 parts of analgesic bacteriostatic agent, 0.6-3 parts of thickening agent, 1-5 parts of nano titanium dioxide powder and 550-650 parts of distilled water.
According to the scheme shown in the embodiment of the invention, the composite sodium chlorite effervescent tablet and the nano titanium dioxide are used as main sterilizing substances, the composite sodium chlorite effervescent tablet has good sterilizing performance, low requirement on humidity, quick dissolution, quick drug effect, high bioavailability and convenient carrying, the nano titanium dioxide is non-toxic and harmless to skin and environment, and has super-strong sterilizing and antibacterial properties, the nano titanium dioxide can kill bacteria and clear away toxic substances released by the bacteria under photocatalysis, the nano titanium dioxide can promote the film formation of the medicated bath agent under the illumination condition, the film formation time of the medicated bath agent is shortened, and the nano titanium dioxide and the composite sodium chlorite have synergistic effect, so that the sterilizing effect is efficient and stable, and the drug resistance cannot be generated; the film forming agent can form a relatively stable protective film on the surface of the cow nipple, so that damaged and swollen parts are protected, and the wound healing is accelerated; the plasticizer can ensure that the formed film has good flexibility and is not easy to break, and the surfactant can enhance the water solubility of each component and improve the permeability of the medicated bath agent; the skin care agent can increase the content of free water in skin, so that the medicated bath agent has a good moisturizing effect; the analgesic bacteriostatic agent can reduce the irritation of the medicated bath agent to the skin of the breasts and nipples of the dairy cow and can promote the synthesis of collagen, and the thickening agent can ensure that a film formed by the film-forming agent has higher toughness and good air permeability, thereby overcoming the defects of the prior art.
According to the first aspect, the composite sodium chlorite effervescent tablet is prepared by mixing and tabletting sodium chlorite, citric acid, sodium bicarbonate, polyethylene glycol and a coating stabilizer, wherein the coating stabilizer is a mixture of anhydrous magnesium sulfate and nano silicon dioxide, and the mass ratio of the anhydrous magnesium sulfate to the nano silicon dioxide is 2-2.4: 1.
The coating stabilizer in the composite sodium chlorite effervescent tablet can not only rapidly absorb the water in the mixed solvent and facilitate the dissolution of the effervescent tablet, but also form crystal water in a difficult separation state, thereby eliminating the influence of free water on a system and improving the stability of the product.
In combination with the first aspect, the film-forming agent is a mixture of sodium alginate and myricitrin chitosan microspheres, wherein the mass ratio of the sodium alginate to the myricitrin chitosan microspheres is 2-2.5: 1.
the sodium alginate has good biocompatibility, hydrophilicity, film forming property and oxidation resistance, the myricitrin chitosan microspheres are obtained by modifying chitosan by using myricitrin, have higher antibacterial activity compared with unmodified chitosan, and can increase the hydrophily and lipophilicity of the chitosan through modification, so that the chitosan can be more stably dispersed in aqueous or oil phase solution, further, the microspheric shape of the myricitrin chitosan microspheres greatly increases the specific surface area of the chitosan, increases the contact area of the chitosan and a solvent, and further ensures that the modified chitosan can be more uniformly and durably dispersed in the solvent. The myricitrin chitosan microsphere embedded composite sodium chlorite can effectively control the drug release, prolong the drug efficacy and increase the drug stability; through the synergistic effect of sodium alginate and myricitrin chitosan microspheres, the medicated bath agent can form a relatively stable protective film on the surface of a cow nipple, and the film has good flexibility, is not easy to break and good in adhesiveness, can protect the existing damaged and swollen part, and further accelerates wound healing.
In combination with the first aspect, the plasticizer is glycerin.
The glycerin can increase the content of secondary bound water in the skin, the glycerin and the polyethylene glycol in the composite sodium chlorite effervescent tablet interact with each other to play a role in helping dissolution, the freezing point of a system can be effectively reduced, and the dairy cow nipple can be effectively prevented from being frozen when the medicated bath agent is used in cold regions.
In combination with the first aspect, the surfactant is a mixture of alkyl glycoside and sodium dodecyl sulfate, wherein the mass ratio of the alkyl glycoside to the sodium dodecyl sulfate is 1.2-2.0: 1.
the alkyl glycoside has good intermiscibility with the skin, can obviously improve the mildness of the medicated bath agent, is nontoxic and nonirritating, and is easy to biodegrade; the sodium dodecyl sulfate can be used as a surfactant to enhance the water solubility of each component, and can be adsorbed on polyethylene glycol molecular chains in the composite sodium chlorite effervescent tablet in a small micelle cluster form to improve the permeability of the medicated bath agent.
In combination with the first aspect, the skin care agent is a mixture of water-soluble lanolin and sorbitol, wherein the mass ratio of the water-soluble lanolin to the sorbitol is 1.5-2: 2.5.
the water-soluble lanolin has good hydrophilicity and a good skin moistening effect, and the sorbitol has good moisturizing performance; the water soluble lanolin can be mixed with glycerol to lower freezing point, and has effect in preventing cold injury of cow skin.
Combining the first aspect, the analgesic bacteriostatic agent is a mixture of a pseudo-ginseng extract, a clove extract and a dark plum extract, wherein the mass ratio of the pseudo-ginseng extract to the clove extract to the dark plum extract is 1.5: 2-2.3: 2 to 2.5.
The pseudo-ginseng extract can promote blood circulation to remove blood stasis and is anti-inflammatory, the dark plum extract has astringent and bacteriostatic effects, the synergistic effect of the pseudo-ginseng extract and the dark plum extract can promote the healing of milk ducts, shorten the opening time of the milk ducts after milking and greatly reduce the chance of bacteria invasion, the clove extract has the effects of relieving pain, resisting inflammation and inhibiting bacteria, and has the synergistic bactericidal effect with the dark plum extract, and the nipple wounds of the dairy cattle can be in a calm and comfortable state.
In combination with the first aspect, the thickener is one or more of sodium carboxymethylcellulose, guar gum, xanthan gum, rhamsan gum, welan gum or gellan gum.
The interaction of the sodium carboxymethylcellulose and the skin care agent can enhance the protective effect on the skin, the film formed by the sodium alginate has the defects of brittleness and poor water resistance, and the interaction of the guar gum, the xanthan gum and the sodium alginate can enable the film formed by the film forming agent to be more flexible, so that the action time of the medicated bath agent is enhanced. The thickening agent and the glycerin interact with each other, so that the contradiction between drip prevention and viscosity is overcome, the milk cow nipple is dipped with a layer of thin and uniform medicinal bath liquid, the sterilization effect is ensured, the dosage is small, the dripping is avoided, and the air permeability required by the milk cow nipple can be met.
With reference to the first aspect, the preparation method of the nano titanium dioxide powder comprises the following steps: respectively grinding titanium dioxide and silicate minerals into powder, and uniformly mixing at 1500-1600 ℃, wherein the mass ratio of the titanium dioxide to the silicate minerals is 2.5-3: 1.
The main component of the silicate mineral is quartz sand which is a porous medium, titanium dioxide and the silicate mineral are ground respectively and then mixed at high temperature, particle impurities on the surface of the quartz sand can fall off through high-temperature roasting, hydroxyl groups are not formed any more, the exposed area of the quartz sand is increased, and the improvement of the surface activity of the quartz sand is facilitated, so that the migration of the titanium dioxide in the quartz sand is promoted, the distribution of nano titanium dioxide at the inlet of the porous medium of the quartz sand is more uniform, and the uniform distribution of the titanium dioxide is facilitated.
The second aspect of the present invention provides a preparation method of the above medicated bath agent for cow nipples, which at least comprises the following steps:
activating the composite sodium chlorite effervescent tablets in distilled water for 10-15 min, and diluting by 10-15 times by adding distilled water to obtain a composite sodium chlorite solution;
mixing the film forming agent, the plasticizer, the surfactant, the skin care agent, the analgesic bacteriostatic agent, the thickening agent, the nano titanium dioxide powder, the distilled water and the composite sodium chlorite solution, and stirring uniformly to obtain the nano titanium dioxide.
The medicated bath agent for the nipples of the milk cows, provided by the invention, has the advantages of simple preparation method, controllable and accessible reaction conditions, natural and nontoxic materials as raw materials, and small irritation to the breasts and the nipple skin of the milk cows.
Optionally, the mass ratio of the composite sodium chlorite effervescent tablet to the distilled water in the activation process is 4: 50-60.
With reference to the second aspect, the content of chlorine dioxide in the composite sodium chlorite solution is 98-105 mg/L.
The cow nipple medicated bath agent provided by the invention releases chlorine dioxide gas when in use, has obvious biological killing capacity on a use part by matching with nano titanium dioxide, and can form a layer of film on the skin of a cow, and the film can protect the existing damaged or swollen part and accelerate wound healing.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
Example 1
The embodiment provides a composite sodium chlorite effervescent tablet, which is prepared by mixing and tabletting sodium chlorite, citric acid, sodium bicarbonate, polyethylene glycol and a coating stabilizer, wherein the mass ratio of the sodium chlorite, the citric acid, the sodium bicarbonate, the polyethylene glycol and the coating stabilizer is 4.7:10.2:0.7:2.4:1.5, the coating stabilizer is a mixture of anhydrous magnesium sulfate and nano silicon dioxide, and the mass ratio of the anhydrous magnesium sulfate to the nano silicon dioxide is 2:1.
Example 2
The embodiment provides a composite sodium chlorite effervescent tablet, which is prepared by mixing and tabletting sodium chlorite, citric acid, sodium bicarbonate, polyethylene glycol and a coating stabilizer, wherein the mass ratio of the sodium chlorite, the citric acid, the sodium bicarbonate, the polyethylene glycol and the coating stabilizer is 5.3:9.8:1.3:1.6:1.5, the coating stabilizer is a mixture of anhydrous magnesium sulfate and nano silicon dioxide, and the mass ratio of the anhydrous magnesium sulfate to the nano silicon dioxide is 2.4:1.
Example 3
The embodiment provides a composite sodium chlorite effervescent tablet, which is prepared by mixing and tabletting sodium chlorite, citric acid, sodium bicarbonate, polyethylene glycol and a coating stabilizer, wherein the mass ratio of the sodium chlorite, the citric acid, the sodium bicarbonate, the polyethylene glycol and the coating stabilizer is 5:10:1:2:1.5, the coating stabilizer is a mixture of anhydrous magnesium sulfate and nano silicon dioxide, and the mass ratio of the anhydrous magnesium sulfate to the nano silicon dioxide is 2.2: 1.
Example 4
This example provides a nano titanium dioxide powder, which is obtained by grinding titanium dioxide and a silicate mineral into powders respectively, and mixing them uniformly at 1500 ℃ (the mass ratio of titanium dioxide to silicate mineral is 3: 1).
Example 5
This example provides a nano titanium dioxide powder, which is prepared by grinding titanium dioxide and a silicate mineral into powders respectively, and mixing them uniformly at 1600 ℃ (the mass ratio of titanium dioxide to silicate mineral is 2.5: 1).
Example 6
This example provides a nano titanium dioxide powder, which is prepared by grinding titanium dioxide and a silicate mineral into powders respectively, and mixing them uniformly at 1550 ℃ (the mass ratio of titanium dioxide to silicate mineral is 2.7: 1).
Example 7
The embodiment provides a medicated bath agent for nipples of dairy cows, which is prepared from the following raw materials in parts by weight: 0.5 part of the composite sodium chlorite effervescent tablet prepared in the example 1, 20 parts of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 2:1), 0.6 part of glycerol, 6 parts of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 2.0:1), 0.5 part of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.5:2.5), 8 parts of an analgesic and bacteriostatic agent (the mass ratio of a panax notoginseng extract, a clove extract and a dark plum extract is 1.5:2.3:2), 0.6 part of sodium carboxymethylcellulose, 5 parts of nano titanium dioxide powder prepared in the example 4 and 550 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting the composite sodium chlorite effervescent tablet into distilled water (the mass ratio of the composite sodium chlorite effervescent tablet to the distilled water is 4:60) for activation for 10min, and adding distilled water for dilution by 15 times to obtain a composite sodium chlorite solution, wherein the content of chlorine dioxide in the composite sodium chlorite solution is 98 mg/L;
mixing the film forming agent, glycerol, surfactant, skin care agent, analgesic bacteriostatic agent, sodium carboxymethylcellulose, nano titanium dioxide powder, distilled water and the composite sodium chlorite solution, and stirring uniformly to obtain the nano sodium chlorite composite.
Example 8
The embodiment provides a medicated bath agent for nipples of dairy cows, which is prepared from the following raw materials in parts by weight: 6 parts of the composite sodium chlorite effervescent tablet prepared in the example 2, 1 part of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 2.5:1), 5 parts of glycerol, 1 part of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.2:1), 3 parts of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 2:2.5), 6 parts of an analgesic and bacteriostatic agent (the mass ratio of a pseudo-ginseng extract, a clove extract and a dark plum extract is 1.5:2:2.5), 3 parts of guar gum, 1 part of the nano titanium dioxide powder prepared in the example 5 and 650 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
the composite sodium chlorite effervescent tablets are put into distilled water (the mass ratio of the composite sodium chlorite effervescent tablets to the distilled water is 4:50) to be activated for 15min, and distilled water is added to dilute the composite sodium chlorite effervescent tablets by 10 times to obtain a composite sodium chlorite solution, wherein the content of chlorine dioxide in the composite sodium chlorite solution is 105 mg/L;
mixing the film forming agent, glycerol, surfactant, skin care agent, analgesic and antibacterial agent, guar gum, nanometer titanium dioxide powder, distilled water and the composite sodium chlorite solution, and stirring uniformly to obtain the product.
Example 9
The embodiment provides a medicated bath agent for nipples of dairy cows, which is prepared from the following raw materials in parts by weight: 3 parts of the composite sodium chlorite effervescent tablet prepared in example 3, 10 parts of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 2.2:1), 2.5 parts of glycerol, 4 parts of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.6:1), 1.5 parts of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.7:2.5), 7 parts of an analgesic and bacteriostatic agent (the mass ratio of a pseudo-ginseng extracting solution, a clove extracting solution and a dark plum extracting solution is 1.5:2.2:2.3), 2 parts of xanthan gum, 3 parts of nano titanium dioxide powder prepared in example 6 and 500 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting the composite sodium chlorite effervescent tablet into distilled water (the mass ratio of the composite sodium chlorite effervescent tablet to the distilled water is 4:55) for activation for 13min, and adding distilled water for dilution by 12 times to obtain a composite sodium chlorite solution, wherein the chlorine dioxide content in the composite sodium chlorite solution is 100 mg/L;
mixing the film forming agent, glycerol, surfactant, skin care agent, analgesic bacteriostatic agent, xanthan gum, nano titanium dioxide powder, distilled water and the composite sodium chlorite solution, and stirring uniformly to obtain the product.
Example 10
The embodiment provides a medicated bath agent for nipples of a dairy cow, which is prepared from the following raw materials in parts by weight: 4 parts of the composite sodium chlorite effervescent tablet prepared in example 3, 15 parts of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 1.4:1), 3 parts of glycerol, 2 parts of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.8:1), 2 parts of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.6:2.5), 7 parts of an analgesic and bacteriostatic agent (the mass ratio of pseudo-ginseng extract, clove extract and dark plum extract is 1.5:2.1:2.2), 3 parts of rhamnose gum, welan gum and gellan gum (the mass ratio of rhamnose gum to welan gum and gellan gum is 1:1:1), 4 parts of the nano titanium dioxide powder prepared in example 6 and 520 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting the composite sodium chlorite effervescent tablets into distilled water (the mass ratio of the composite sodium chlorite effervescent tablets to the distilled water is 4:55) for activation for 12min, and adding distilled water for dilution by 13 times to obtain a composite sodium chlorite solution, wherein the chlorine dioxide content in the composite sodium chlorite solution is 102 mg/L;
mixing film-forming agent, glycerol, surfactant, skin care agent, analgesic and antibacterial agent, rhamsan gum, welan gum and gellan gum, nanometer titanium dioxide powder and distilled water with composite sodium chlorite solution, and stirring.
Comparative example 1
The comparative example provides a cow nipple medicated bath agent tested in the research process, which is prepared from the following raw materials in parts by weight: 3 parts of the composite sodium chlorite effervescent tablet prepared in the embodiment 3, 10 parts of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 2.2:1), 2.5 parts of glycerol, 4 parts of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.6:1), 1.5 parts of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.7:2.5), 7 parts of an analgesic and bacteriostatic agent (the mass ratio of a panax notoginseng extract, a clove extract and a dark plum extract is 1.5:2.2:2.3), 2 parts of xanthan gum and 500 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting the composite sodium chlorite effervescent tablet into distilled water (the mass ratio of the composite sodium chlorite effervescent tablet to the distilled water is 4:55) for activation for 13min, and adding distilled water for dilution by 12 times to obtain a composite sodium chlorite solution, wherein the chlorine dioxide content in the composite sodium chlorite solution is 100 mg/L;
mixing the film forming agent, glycerol, surfactant, skin care agent, analgesic bacteriostatic agent, xanthan gum and distilled water with the composite sodium chlorite solution, and stirring uniformly to obtain the product.
Comparative example 2
The comparative example provides a cow nipple medicated bath agent tested in the research process, which is prepared from the following raw materials in parts by weight: 3 parts of the composite sodium chlorite effervescent tablet prepared in the embodiment 3, 10 parts of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 2.2:1), 2.5 parts of glycerol, 4 parts of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.6:1), 1.5 parts of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.7:2.5), 7 parts of an analgesic and bacteriostatic agent (the mass ratio of a panax notoginseng extract, a clove extract and a dark plum extract is 1.5:2.2:2.3), 2 parts of xanthan gum, 3 parts of commercially available nano titanium dioxide powder and 500 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting the composite sodium chlorite effervescent tablet into distilled water (the mass ratio of the composite sodium chlorite effervescent tablet to the distilled water is 4:55) for activation for 13min, and adding distilled water for dilution by 12 times to obtain a composite sodium chlorite solution, wherein the chlorine dioxide content in the composite sodium chlorite solution is 100 mg/L;
mixing film forming agent, glycerol, surfactant, skin care agent, analgesic bacteriostatic agent, xanthan gum, commercially available nanometer titanium dioxide powder, distilled water and composite sodium chlorite solution, and stirring.
Comparative example 3
The comparative example provides a cow nipple medicated bath agent tested in the research process, which is prepared from the following raw materials in parts by weight: 4 parts of a commercially available sodium chlorite effervescent tablet, 15 parts of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 1.4:1), 3 parts of glycerol, 2 parts of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.8:1), 2 parts of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.6:2.5), 7 parts of an analgesic and bacteriostatic agent (the mass ratio of a pseudo-ginseng extract, a clove extract and a dark plum extract is 1.5:2.1:2.2), 3 parts of rhamnose gum, welan gum and gellan gum (the mass ratio of the rhamnose gum to the welan gum and the gellan gum is 1:1:1), 4 parts of the nano titanium dioxide powder prepared in example 6 and 520 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting a commercially available sodium chlorite effervescent tablet into distilled water (the mass ratio of the sodium chlorite effervescent tablet to the distilled water is 4:55) for activation for 12min, and adding distilled water for dilution by 13 times to obtain a composite sodium chlorite solution, wherein the chlorine dioxide content in the composite sodium chlorite solution is 102 mg/L;
mixing film-forming agent, glycerol, surfactant, skin care agent, analgesic and antibacterial agent, rhamsan gum, welan gum and gellan gum, nanometer titanium dioxide powder and distilled water with composite sodium chlorite solution, and stirring.
Comparative example 4
The comparative example provides a cow nipple medicated bath agent tested in the research process, which is prepared from the following raw materials in parts by weight: 4 parts of the composite sodium chlorite effervescent tablet prepared in example 3, 3 parts of glycerol, 2 parts of surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.8:1), 2 parts of skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.6:2.5), 7 parts of analgesic and antibacterial agent (the mass ratio of pseudo-ginseng extract, clove extract and dark plum extract is 1.5:2.1:2.2), 3 parts of rhamnose gum, welan gum and gellan gum (the mass ratio of rhamnose gum to welan gum and gellan gum is 1:1:1), 4 parts of nano titanium dioxide powder prepared in example 6 and 520 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting the composite sodium chlorite effervescent tablet into distilled water (the mass ratio of the composite sodium chlorite effervescent tablet to the distilled water is 4:55) for activation for 12min, and adding distilled water for dilution by 13 times to obtain a composite sodium chlorite solution, wherein the chlorine dioxide content in the composite sodium chlorite solution is 102 mg/L;
mixing commercially available film forming agent, glycerol, surfactant, skin care agent, analgesic and antibacterial agent, rhamsan gum, welan gum and gellan gum, nanometer titanium dioxide powder and distilled water with composite sodium chlorite solution, and stirring.
Comparative example 5
The comparative example provides a cow nipple medicated bath agent tested in the research process, which is prepared from the following raw materials in parts by weight: 4 parts of a composite sodium chlorite effervescent tablet prepared in example 3, 15 parts of a film forming agent (the mass ratio of sodium alginate to myricitrin chitosan microspheres is 1.4:1), 3 parts of glycerol, 2 parts of a surfactant (the mass ratio of alkyl glycoside to sodium dodecyl sulfate is 1.8:1), 2 parts of a skin care agent (the mass ratio of water-soluble lanolin to sorbitol is 1.6:2.5), 7 parts of a commercially available guanidine disinfectant, 7 parts of rhamnose gum, welan gum and gellan gum (the mass ratio of rhamnose gum to welan gum and gellan gum is 1:1:1), 3 parts of nano titanium dioxide powder prepared in example 6 and 520 parts of distilled water;
the preparation method of the cow nipple medicated bath agent at least comprises the following steps:
putting the composite sodium chlorite effervescent tablet into distilled water (the mass ratio of the composite sodium chlorite effervescent tablet to the distilled water is 4:55) for activation for 12min, and adding distilled water for dilution by 13 times to obtain a composite sodium chlorite solution, wherein the chlorine dioxide content in the composite sodium chlorite solution is 102 mg/L;
mixing film-forming agent, glycerol, surfactant, skin care agent, commercially available guanidine disinfectant, rhamsan gum, welan gum and gellan gum, nanometer titanium dioxide powder, distilled water and composite sodium chlorite solution, and stirring.
Effect example 1
1. Material
1.1 disinfectant: cow nipple medicated bath agent prepared in examples 7 to 10 and comparative examples 1 to 5;
1.2 bacteria: escherichia coli (CMCC44102), staphylococcus aureus (CMCC 26003);
1.3 neutralizing agent: 1% sodium thiosulfate;
1.4 dilution: 0.9% sodium chloride injection.
2. Method (refer to technical Specification for identifying disinfectant for veterinary use (1992) No. 101 of agricultural (herding medicine))
Counting viable bacteria of the prepared bacterial liquid, and diluting the bacterial liquid into experimental bacterial liquid containing 106-107 bacteria/ml by using sodium chloride injection; respectively preparing disinfectant samples into test concentrations of 1: 600; sucking 0.5ml of experimental bacteria liquid into 4.5ml of disinfectant solution with a test concentration; fully reacting the disinfectant with the bacterial liquid for 5min and 10 min; immediately sucking 0.5ml of the above mixed solution of bacteria and drug 5min and 10min after adding bacteria solution, adding 4.5ml of neutralizing solution, and mixing; neutralizing for 10min, taking out 0.1ml, and uniformly coating in a culture dish with nutrient agar culture medium; placing the culture dish at 37 ℃ for culturing for 24h, and counting the number of colonies; sodium chloride injection (0.9%) was used in place of the disinfectant, and the above steps were performed simultaneously to serve as a control; two parallel controls were set for each of the above steps. The results of the disinfectant with different dilution times on killing escherichia coli and staphylococcus aureus are shown in table 1.
TABLE 1
The data show that the medicated bath agent for the nipples of the cows provided by the invention has excellent sterilizing performance on the using parts, has longer stable time than the traditional medicated bath agent, can release more chlorine dioxide content in a short time, can realize the prevention and treatment of mastitis of the cows, can form a protective film after sterilization is finished, achieves the effect of preventing bacteria, effectively reduces the illness probability of the cows, and has excellent effect.
Effect example 2
100 healthy rabbits of similar body weight were selected and randomly divided into 10 groups of 10 rabbits each, 4 example groups, 5 comparative example groups and one control group. Depilatory was applied to the dorsal spine of rabbits in 1 area of about 3cm by 3cm, and the depilated skin was cleaned with 75% alcohol and then sterilized. After the sterilization was completed, a "well" shaped damaged wound was scratched with an injection needle in the depilating area at a scratch interval of 0.5 cm. The hair removal areas of 4 rabbits of the example group were coated with the medicated bath agents of examples 7 to 10, the hair removal areas of rabbits of the comparative example group were coated with the medicated bath agents of comparative examples 1 to 5, and the hair removal areas of the rabbits of the comparative example group were coated with only physiological saline, covered with gauze after coating, and fixed with medical rubber. After the patch is fixed for 24 hours, the patch is removed, the patch is cleaned by warm water to suck the water, the local reaction of the skin is observed, and the conditions of erythema and edema exist, and the experimental result is shown in a table 2:
TABLE 2
As can be seen from the data in table 2, the medicated bath agent provided by the present invention is less irritating to the skin.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. The medicated bath agent for the nipples of the milk cows is characterized by being prepared from the following raw materials in parts by weight: 0.5-6 parts of composite sodium chlorite effervescent tablets, 1-20 parts of film forming agent, 0.6-5 parts of plasticizer, 1-6 parts of surfactant, 0.5-3 parts of skin care agent, 6-8 parts of analgesic and bacteriostatic agent, 0.6-3 parts of thickening agent, 1-5 parts of nano titanium dioxide powder and 550-650 parts of distilled water.
2. The medicated bath for cow teats as set forth in claim 1, wherein: the composite sodium chlorite effervescent tablet is prepared by mixing and tabletting sodium chlorite, citric acid, sodium bicarbonate, polyethylene glycol and a coating stabilizer, wherein the mass ratio of the sodium chlorite, the citric acid, the sodium bicarbonate, the polyethylene glycol and the coating stabilizer is 4.7-5.3: 9.8-10.2: 0.7-1.3: 1.6-2.4: 1.5, the coating stabilizer is a mixture of anhydrous magnesium sulfate and nano silicon dioxide, and the mass ratio of the anhydrous magnesium sulfate to the nano silicon dioxide is 2-2.4: 1.
3. The medicated bath for cow teats as set forth in claim 1, wherein: the film forming agent is a mixture of sodium alginate and myricitrin chitosan microspheres, wherein the mass ratio of the sodium alginate to the myricitrin chitosan microspheres is 2-2.5: 1.
4. The medicated bath for cow teats as set forth in claim 1, wherein: the plasticizer is glycerol; and/or
The surfactant is a mixture of alkyl glycoside and sodium dodecyl sulfate, wherein the mass ratio of the alkyl glycoside to the sodium dodecyl sulfate is 1.2-2.0: 1.
5. The medicated bath for cow teats as set forth in claim 1, wherein: the skin care agent is a mixture of water-soluble lanolin and sorbitol, wherein the mass ratio of the water-soluble lanolin to the sorbitol is 1.5-2: 2.5.
6. The cow nipple medicated bath agent according to claim 1, wherein the analgesic bacteriostatic agent is a mixture of a pseudo-ginseng extract, a clove extract and a dark plum extract, wherein the mass ratio of the pseudo-ginseng extract, the clove extract and the dark plum extract is 1.5: 2-2.3: 2-2.5.
7. The medicated bath agent for cow's teats according to claim 1, wherein the thickener is one or more of sodium carboxymethylcellulose, guar gum, xanthan gum, rhamsan gum, welan gum or gellan gum.
8. The cow nipple medicated bath agent according to claim 1, wherein the preparation method of the nano titanium dioxide powder comprises: respectively grinding titanium dioxide and silicate minerals into powder, and uniformly mixing at 1500-1600 ℃, wherein the mass ratio of the titanium dioxide to the silicate minerals is 2.5-3: 1.
9. The method for preparing the cow teat dipping solution according to any one of claims 1 to 8, comprising at least the steps of:
putting the composite sodium chlorite effervescent tablets into the distilled water for activation for 10-15 min, and adding the distilled water for dilution by 10-15 times to obtain a composite sodium chlorite solution;
and mixing and stirring the film forming agent, the plasticizer, the surfactant, the skin care agent, the analgesic bacteriostatic agent, the thickening agent, the nano titanium dioxide powder and the distilled water with the composite sodium chlorite solution uniformly to obtain the composite sodium chlorite solution.
10. The method for preparing the medicated bath agent for cow nipples as claimed in claim 9, wherein the content of chlorine dioxide in the composite sodium chlorite solution is 98-105 mg/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210463462.1A CN114652767B (en) | 2022-04-28 | 2022-04-28 | Dairy cow nipple medicated bath agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210463462.1A CN114652767B (en) | 2022-04-28 | 2022-04-28 | Dairy cow nipple medicated bath agent and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114652767A true CN114652767A (en) | 2022-06-24 |
| CN114652767B CN114652767B (en) | 2023-05-02 |
Family
ID=82037406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210463462.1A Active CN114652767B (en) | 2022-04-28 | 2022-04-28 | Dairy cow nipple medicated bath agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114652767B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023016442A1 (en) * | 2021-08-10 | 2023-02-16 | 帝斯曼知识产权资产管理有限公司 | Compound thickening agent and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2635439A1 (en) * | 1988-08-19 | 1990-02-23 | Produits Ind Cie Fse | PREPARATION OF A CLEANER DISINFECTANT TO PREVENT SUBCLINKEN MAMMITE IN RUMINANTS |
| CN108030705A (en) * | 2017-12-25 | 2018-05-15 | 河北科技大学 | A kind of compound sodium chlorite effervesce for oral care is gargled tablet and preparation method |
| US20180360047A1 (en) * | 2015-08-06 | 2018-12-20 | International Capital Investment Llc | Disinfectant for drinkable water, food contact, industry, spas, swimming pools and air sterilization |
| CN110013472A (en) * | 2019-04-30 | 2019-07-16 | 扬州大学 | A kind of mammilla of milk cattle film forming Medicatedbath lotion, preparation method and its application method |
| CN110420257A (en) * | 2019-08-30 | 2019-11-08 | 陕西汉隆清洁科技有限公司 | A kind of compound mammilla of milk cattle dip and preparation method thereof |
-
2022
- 2022-04-28 CN CN202210463462.1A patent/CN114652767B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2635439A1 (en) * | 1988-08-19 | 1990-02-23 | Produits Ind Cie Fse | PREPARATION OF A CLEANER DISINFECTANT TO PREVENT SUBCLINKEN MAMMITE IN RUMINANTS |
| US20180360047A1 (en) * | 2015-08-06 | 2018-12-20 | International Capital Investment Llc | Disinfectant for drinkable water, food contact, industry, spas, swimming pools and air sterilization |
| CN108030705A (en) * | 2017-12-25 | 2018-05-15 | 河北科技大学 | A kind of compound sodium chlorite effervesce for oral care is gargled tablet and preparation method |
| CN110013472A (en) * | 2019-04-30 | 2019-07-16 | 扬州大学 | A kind of mammilla of milk cattle film forming Medicatedbath lotion, preparation method and its application method |
| CN110420257A (en) * | 2019-08-30 | 2019-11-08 | 陕西汉隆清洁科技有限公司 | A kind of compound mammilla of milk cattle dip and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 温富勇等: "应用纳米级二氧化钛对奶牛乳房药浴降低体细胞", 《当代畜牧》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023016442A1 (en) * | 2021-08-10 | 2023-02-16 | 帝斯曼知识产权资产管理有限公司 | Compound thickening agent and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114652767B (en) | 2023-05-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101278896B (en) | Chitosan nano silver gel agent and uses thereof | |
| CN105012993B (en) | A kind of cation Medical Living Creature Gum antiseptic dressing and preparation method thereof | |
| CN107185031B (en) | A kind of biologically active medical dressing and preparation method thereof | |
| CN102670929B (en) | Composite for injury healing and preparing method thereof | |
| CN109316536A (en) | A kind of skin mucosa disinfecting agent and preparation method thereof | |
| CN109432481A (en) | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof | |
| CN108158995A (en) | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof | |
| CN108042578A (en) | A kind of health care vaginal jellies containing compound probiotic ingredient | |
| CN101543658B (en) | Cervical cap for preventing and treating cervical erosion and preparation method thereof | |
| CN107982277B (en) | Composite antibacterial aerosol and preparation method and application thereof | |
| CN114652767B (en) | Dairy cow nipple medicated bath agent and preparation method thereof | |
| CN102405935B (en) | Protamine compounded preparation, preparation method and application thereof | |
| CN106063798B (en) | Oral ulcer treatment patch film and preparation method thereof | |
| CN104257684A (en) | Medicated bath liniment for cow nipples and preparation method of medicated bath liniment | |
| CN1367018A (en) | Compound preparation of staphylococcolysis enzyme and its preparation method and application | |
| CN104288222B (en) | A kind of Nano medication for treating cow endometritis and preparation method thereof | |
| CN108404111A (en) | One kind is with kidney bean phytolectin inhibitory anti-virus preparation as main component | |
| CN111407789A (en) | Foam type bath lotion for daily prevention and treatment of animal hooves as well as preparation method and application thereof | |
| CN111905058A (en) | Pharmaceutical composition for skin mucosa nursing and wound repair and preparation method thereof | |
| CN109200326A (en) | Dressing and bandage for wound healing | |
| CN105079000B (en) | A kind of composition and its application, preparation | |
| EP2170081A1 (en) | Antimicrobial compositions | |
| CN108096276A (en) | A kind of debridement healing washing lotion and its application | |
| RU2535141C1 (en) | Gel composition of wide spectrum of biological action | |
| CN100388949C (en) | Lysostaphin freeze dried powder used for preventing and treating cattle edometritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |