CN107873701A - A kind of aerosol for expelling parasite, sterilizing and mite killing and preparation method thereof - Google Patents
A kind of aerosol for expelling parasite, sterilizing and mite killing and preparation method thereof Download PDFInfo
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- CN107873701A CN107873701A CN201711089409.5A CN201711089409A CN107873701A CN 107873701 A CN107873701 A CN 107873701A CN 201711089409 A CN201711089409 A CN 201711089409A CN 107873701 A CN107873701 A CN 107873701A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/06—Oxygen or sulfur directly attached to a cycloaliphatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/20—Fabaceae or Leguminosae [Pea or Legume family], e.g. pea, lentil, soybean, clover, acacia, honey locust, derris or millettia
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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Abstract
The invention discloses a kind of aerosol for expelling parasite, sterilizing and mite killing and preparation method thereof, belong to aerosol spray technique field.It is made up of the raw material of following weight percent content：Menthol 0.1% 0.5%, thymol 0.1% 0.5%, natural botanical extraction liquid 0.5% 1.0%, natural plant essential oils 0.5% 1.0%, rilanit special 1.0% 1.5%, ethylene glycol 1.0% 1.5%, corrosion inhibiter 0.2% 0.5% and propellant 20% 35%, surplus is deionized water；Natural botanical extraction liquid includes：The 20wt% of cinerin 0, the 60wt% of Radix Sophorae Flavescentis extractive liquid 5, surplus is ethylene glycol；Natural plant essential oils include：The 40wt% of citronella oil 5, the 15wt% of citral 5, surplus is ethylene glycol.Bactericidal effect of the aerosol with wide spectrum and the time is walked quickly and kept away with longer, can guarantee that the activity of natural botanical extraction liquid and natural plant essential oils.
Description
Technical field
The invention belongs to aerosol spray technique field, and in particular to it is a kind of for expelling parasite, sterilizing and mite killing aerosol and its
Preparation method.
Background technology
Household insecticide has a long history, and China has with various natural plants, mineral before thousands of years
Smoke fire burns the record of mosquito.By thousands of years of differentiation, it is now widely used for mainly having mosquito in terms of mosquito control
Fragrant, electric culicifuge incense, vaporizer mosquito liquid, aerosol, spray etc..The Medication structure of these insecticides also several times changes, as plan is removed
Worm chrysanthemum esters medicine succeed in developing and extensive use, this kind of efficiently, hygienic medication of low toxicity, safety gradually instead of to people and animals with
Environment has the medicines such as the Ba Sha of serious harm.Mosquito-repellent incense is so that its is cheap, easy to use, goes through in the product of this numerous mosquito
The features such as history is long, repelling effect is preferable is got close to by consumers in general.
It is well known that one of mosquito and the fly category four pests, not only pollute environment but also infect disease, many diseases of the mankind
All there is direct relation with both insects.So over the past thousands of years, people, which work as elimination mosquito and fly, to accomplish anything to treat.
With using and developing for mosquitos and flies medicine is killed, mosquitos and flies is also resulted in the drug-fast enhancing of these medicines, therefore continue to increase medicine
The toxicity of product also brings bigger pollution to environment, the health to the mankind also result in more harm.According to scientific research institution
Testing result show, can detect that a number of organic chemical pesticides are residual in many species bodies in present nature
Stay, even can also detect a small amount of organic chemical pesticides in the penguin body of South Pole life.Many plants, animal in nature
Even atmosphere, is all shrouded by the residue of organic chemistry.
More and more extensive with the application of agricultural chemicals, the mankind are also more and more deep to the understanding of agricultural chemicals.The concept of agricultural chemicals, especially
It is the concept of insecticide, has occurred that deep change.Today, we do not focus on " killing ", but focus on " regulation ".
Preferable insecticide should be " the reasonable insecticide of biology " in public mind, i.e., pacify to pest efficient, to environment, to non-target organism
Full insecticide.Currently used insecticide mainly has organic phosphates, chrysanthemum esters, carbamates, nicotinoids etc., has not
With the drug-fast relevant report of degree.
Playing the role of many plants in nature, either isolate all has except mite or expelling parasite, such as Radix Sophorae Flavescentis extractive liquid, in vain
Flower pyrethrin etc., its relative to chemical pest repellant have the advantages that it is small to human toxicity, easily decompose.
Made of Radix Sophorae Flavescentis extractive liquid is the root by Chinese herbal medicine kuh-seng, stem, leaf, fruit extraction, main component has matrine
(Matrine, C15H24N2), oxymatrine (Oxymatrine, C15H24N2O2), Iosmatrine (Iosmatrine,
C15H24N2O), sophocarpine (Sophocarpine, C15H22N2O) etc., commonly referred to as Banlangen, is a kind of natural plant source
Agricultural chemicals.Radix Sophorae Flavescentis extractive liquid to insect through tagging, stomach poison function make insect nerve center paralysis then make polypide protein coagulation, block
Polypide stomata, makes insect be choked to death, particular for acarid, excellent.A variety of chemical substance collective effects in matrine, no
It can be developed immunity to drugs because single component acts on.
Cinerin is a kind of insecticide for extracting from chrysanthemum cinesariaefolium, and it is easily decomposed in illumination and air, right
The virulence of insect is big, but for homeothermal animal but fool proof.Cinerin is a kind of environmentally friendly kills
Worm agent, its environmentally safe, noresidue, have been widely cited in agricultural and daily life.
But the active ingredient in natural insecticide, such as Radix Sophorae Flavescentis extractive liquid, cinerin is easily divided in atmosphere
Solution, its wide effect and continuous disinfection effect can not be realized.
The content of the invention
In order to solve upper problem, an object of the present invention is to provide a kind of aerosol for expelling parasite, sterilizing and mite killing,
Bactericidal effect of the aerosol with wide spectrum and the time is walked quickly and kept away with longer, can guarantee that natural botanical extraction liquid and natural plants
The activity of essential oil；The second object of the present invention there is provided the preparation method of foregoing aerosol, for Radix Sophorae Flavescentis extractive liquid etc. is easy
The active ingredient of decomposition is enclosed in sealed shell of tank and provides special environment, it is not decomposed, and aerosol makes it after spraying
Dispersed formation water-base disperse system, can guarantee that and walk quickly and keep away effect more than 6 hours.The technical scheme is as follows：
On the one hand, the embodiments of the invention provide a kind of aerosol for expelling parasite, sterilizing and mite killing, the aerosol is by following heavy
The raw material of amount degree is made：Menthol 0.1%-0.5%, thymol 0.1%-0.5%, natural botanical extraction liquid 0.5%-
1.0%th, natural plant essential oils 0.5%-1.0%, rilanit special 1.0%-1.5%, ethylene glycol 1.0%-1.5%, corrosion inhibiter 0.2%-
0.5% and propellant 20%-35%, surplus are deionized water.Wherein, natural botanical extraction liquid includes：Cinerin 0-
20wt%, Radix Sophorae Flavescentis extractive liquid 5-60wt%, surplus are ethylene glycol；The natural plant essential oils include：Citronella oil 5-40wt%, lemon
Aldehyde 5-15wt%, surplus are ethylene glycol.
Preferably, aerosol provided by the invention is made up of the raw material of following weight percent content：Menthol 0.2%, hundred
In phenol 0.2%, natural botanical extraction liquid 1.0%, natural plant essential oils 1.0%, rilanit special 1.5%, ethylene glycol 1.0%, corrosion inhibiter
0.4% and propellant 30%, surplus be deionized water.Wherein, natural botanical extraction liquid includes：Cinerin 15wt%, kuh-seng
Extract solution 55wt%, surplus are ethylene glycol；Natural plant essential oils include：Citronella oil 30wt%, citral 10wt%, surplus are second two
Alcohol.
Wherein, aerosol is made in above-mentioned each raw material.
Wherein, in said components：Thymol and menthol are respectively provided with bactericidal effect and all have pleasant aroma
Taste；Thymol and menthol are respectively provided with good as expelling parasite and the main matter of mite killing to acarid, protoscolex, housefly and culex etc.
Good effect, thymol and menthol synergy have preferably sterilization and insecticidal action；Meanwhile menthol and natural plants
Essential oil has the function that to provide novel aroma；Rilanit special is emulsifying agent, makes active ingredient scattered more uniformly, effect is more
Persistently, and its is environmentally friendly；Ethylene glycol is used for the solubility for increasing active ingredient and the work with certain moisture absorption and moisturizing
With；Propellant is used to provide power during spraying, makes active ingredient atomization uniform, more scattered.
Wherein, wherein, citronella oil is also known as vanilla flavour concentrate or citronella oil.Obtained by the herb of lemongrass through steam distillation.It is yellowish
Color liquid.There is strong Chinese pepper fragrance.Main component is citronellal, geraniol and citronellol.For extracting citronellal, for synthesis
Laurine, geraniol and menthol.It also is used as insecticide, anophelifuge and soap perfume.In addition, citronella oil can be used as it is molten
Agent is used to dissolve the organic matters such as menthol.Its main function is desinsection and provides fragrance.
Wherein, the molecular formula of citral is C10H16O, it is one of most important representative in open chain monoterpene.It is present in lemon-grass oil
In litsea citrate oil.Natural lemon aldehyde is the mixture of two kinds of geometric isomer compositions.Colourless or slightly yellow liquid, in strong lemon
Lemon fragrance.Oxidizable flavescence in atmosphere, redox reaction generation geranic acid or transformation of geraniol/nerol easily occurs.It is led
It is used to provide fragrance.
In above-mentioned raw materials, cinerin, Radix Sophorae Flavescentis extractive liquid and citral etc. are all easily aoxidized or decomposed, using normal
Rule mode（As vial encapsulates）The discoloration of ineffective or product can be caused.The present invention by foregoing each raw material by pressing certain agent
Spray is made in amount, and it not only acts synergistically with more preferable expelling parasite, sterilizing and acaricidal action, has without adding compound essence
There is natural delicate fragrance, remained using rear harmful substance few；Meanwhile cinerin, Radix Sophorae Flavescentis extractive liquid and citral etc. are effective
Material will not be aoxidized or decomposed, long action time.
Wherein, the corrosion inhibiter in the embodiment of the present invention be selected from ring ethylamine, sodium benzoate, natrium nitrosum, ammonium benzoate and
One or more in sodium molybdate etc..
Wherein, one kind in dimethyl ether, propane, normal butane and iso-butane etc. of the propellant in the embodiment of the present invention or
It is a variety of.
Preferably, the propellant in the embodiment of the present invention is dimethyl ether.
Wherein, the rilanit special in the embodiment of the present invention marked as AA220.
Preferably, aerosol provided by the invention is made up of the raw material of following weight percent content：Menthol 0.2%, hundred
In phenol 0.2%, natural botanical extraction liquid 1.0%, natural plant essential oils 1.0%, rilanit special AA220 1.5%, ethylene glycol 1.0%,
Corrosion inhibiter 0.4% and dimethyl ether 30%, surplus are deionized water.Wherein, natural botanical extraction liquid includes：Cinerin
15wt%, Radix Sophorae Flavescentis extractive liquid 55wt%, surplus are ethylene glycol；Wherein, natural plant essential oils include：Citronella oil 30wt%, citral
10wt%, surplus are ethylene glycol.
On the other hand, the embodiments of the invention provide the preparation method of foregoing aerosol, this method to comprise the following steps：
(1) menthol, thymol, natural plant essential oils, natural botanical extraction liquid are added in ethylene glycol by proportioning and dissolved, then pressed
Proportioning adds rilanit special, and transparent brown emulsion is obtained after mixing.
(2) corrosion inhibiter is added in deionized water by proportioning, clear solution is obtained after mixing.
(3) after the transparent brown emulsion that step (1) obtains is mixed with the clear solution that step (2) obtains by proportioning, then
Propellant is added by proportioning, and aerosol is made.
In the preparation method, it is evenly distributed on by the respective characteristic of raw material in corresponding system, and it is uniform at normal temperatures
Mixing, it ensure that active principle is not decomposed or aoxidized and dispersed.
The beneficial aspect of the present invention has：
(1) bio-toxicity of each component in the present invention and insecticidal effect can compare favourably with chemical synthesis insecticide completely.
(2) present invention uses natural plant composition, noresidue, and most fast composition can divide completely in one week in atmosphere
Solution, it is free from environmental pollution, to not producing harm outside human body and insect.
(3) present invention uses aerosol form, can stablize and ensure drug effect, and various plants extract compounds, and has and kills
The multiple efficacies such as worm except mite, pest-resistant, expelling parasite.
(4) because supplied materials is natural, composition is more complicated, does not produce any resistance to the action of a drug.
(5) raw material sources that the present invention uses are extensive, and preparation method is simple, and cost is cheap, can be with large-scale promotion.
(6) containing a large amount of compositions with nature delicate fragrance in the present invention, without adding compound essence, Consumer's Experience is good.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, present invention work is further retouched in detail below
State.
Embodiment 1
Embodiment 1 provides a kind of aerosol for expelling parasite, sterilizing and mite killing and preparation method thereof, and this method includes following step
Suddenly：
(1) by menthol 2g, thymol 2g, natural botanical extraction liquid 10g（Consisting of：Cinerin 15wt%, kuh-seng
Extract solution 55wt%, surplus are ethylene glycol）And natural plant essential oils（Consisting of：Citronella oil 30wt%, citral 10wt%, surplus
For ethylene glycol）10g, add in 10g ethylene glycol and dissolve, add 15g rilanit specials（Marked as AA220）, obtained after mixing
Transparency emulsion.
(2) 4g sodium benzoates are added in 670g deionized waters, clear solution is obtained after mixing.
(3) clear solution that the transparency emulsion for obtaining step (1) obtains with step (2) loads in inhalator jar after mixing,
After aerosol valve sealed cans, 300g dimethyl ethers are added into aerosol.
The performance of the aerosol provided embodiment 1 is tested, and common water base insecticide is also simultaneously spray（For city
Product is sold, containing menthol）, its result is as follows：
Table 1
| Project | Index | Common water base insecticide | Present example 1 |
| Acidity a）(in terms of HCl), %≤ | 0.02 | 0.015 | 0.01 |
| Condensation rate b）, % >= | 98 | 98.5 | 99 |
| Interior pressure（55±2）DEG C, MPa | 0.5-1.0 | 0.87 | 0.89 |
| Ejection speed, g/s >= | 2 | 2.5 | 3.1 |
| Heat storage stability d）(54 DEG C ± 2 DEG C, 14d) | Active ingredient resolution ratio≤5%, spray speed >=2g/s, net content >=390g | It is qualified | It is qualified |
| Mite killing | Nothing | In 100%12 hours | |
| Bactericidal effect | Nothing | ≤15cfu/cm2 |
As can be seen from Table 1, all technical of aerosol provided by the invention meet national standard technology will
Ask, and be better than in terms of condensation rate, spouting velocity using common water base insecticide.
Embodiment 2
Embodiment 2 provides another aerosol for being used for expelling parasite, sterilizing and mite killing and preparation method thereof, and this method includes following
Step：
(1) by menthol 2g, thymol 4g, natural botanical extraction liquid（Consisting of：Radix Sophorae Flavescentis extractive liquid 30wt%, surplus are second two
Alcohol）6g, natural plant essential oils（Consisting of：Citronella oil 15wt%, citral 10wt%, surplus are ethylene glycol）10g, add 6g second
Dissolved in glycol, add 10g rilanit specials（Marked as AA220）, transparency emulsion is obtained after mixing.
(2) 5g natrium nitrosums are added sequentially in 660g deionized waters, clear solution is obtained after mixing.
(3) clear solution that the transparency emulsion for obtaining step (1) obtains with step (2) loads in inhalator jar after mixing,
After aerosol valve sealed cans, 300g dimethyl ethers are added into aerosol.
Embodiment 3-6
Embodiment 3-6 is identical with the preparation method of embodiment 2, and difference is：The raw material and proportioning used is had any different, its group
Into as shown in table 1：
Table 1
| Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Menthol (g) | 1 | 3 | 5 | 2 |
| Thymol (g) | 5 | 2 | 4 | 1 |
| Rilanit special (g) | 15 | 10 | 12 | 15 |
| Natural botanical extraction liquid | 10 | 9 | 8 | 9 |
| Natural plant essential oils (g) | 5 | 6 | 8 | 8 |
| Ethylene glycol (g) | 9 | 9 | 13 | 11 |
| Corrosion inhibiter species | Natrium nitrosum | Sodium benzoate | Sodium benzoate+natrium nitrosum | Ammonium benzoate |
| Corrosion inhibiter (g) | 4 | 2 | 3+1 | 5 |
| Propellant species | Normal butane | Propane | Dimethyl ether+propane | Dimethyl ether |
| Propellant (g) | 300 | 290 | 150+150 | 260 |
Effect example
1. in Room mosquito repellent and walk quickly and keep away the time experiment
Material to be tested：Aedes albopictus, -5 days 3 days female insects do not sucked blood after emergence.
Mosquito cage：Long 400mm, wide 300mm, high 300mm.
Experimental condition：Temperature（26±1）DEG C, relative humidity 65% ± 10%.
Attack is tested：300 test worms are put into mosquito cage, testing crew arm exposes 40mm × 40mm skin areas, its
Remaining part point tightly hides.Arm is stretched into 2min is placed in mosquito cage, observation finds that mosquito stops falling, before its mouthpart will be pierced into skin
Shake arm is expelled, and is designated as 1 test worm and is stopped falling.Tester and the test worm that the test worm for coming to stop falling is more than 30 are attack
Power is qualified, and this person and this cage mosquito can carry out repellency test.
Repellency test：Select 4 and the qualified testing crew of above attack（Men and women half and half, and before experiment and during experiment
It should not drink, tea or coffee, the product of the class containing essence should not be used）, 50mm × 50mm skin is respectively drawn in its both hands the back of the hand
Area a, wherein hand presses 1.5 μ L/cm2Dose uniformity smear repellant to be measured, exposure 40mm × 40mm therein skin
Skin, tightly cover remainder.Another hand is blank control.After smearing repellant 2h, hand is stretched into the qualified mosquito of attack
2min in cage, observation, which whether there is mosquito, is come to stop to fall to suck blood.Afterwards at interval of 1h tests once, as long as there is a mosquito to come to inhale
Blood, which is sentenced, makees repellant failure.Record repellant effective protecting time（h）.Control hand first does control test every time, and attack closes
The test worm of lattice can continue to test, and test worm attack is unqualified, need to change qualified test worm and tested.As a result such as following table.
Table 3
As a result show, the aerosol that embodiment 1-6 is provided, due to using natural plant essential oils composition and other active ingredients, drive
Avoiding effect can reach National Standard of the People's Republic of China GB-T13917.9-2009 A class standards, walks quickly and keeps away the time and is more than
6.5 hours, and the time of walking quickly and keeping away of conventional water-based spray agent is less than 4 hours.
2. aroma sensory's evaluation experimental
Subjective appreciation is carried out to 42 people, is randomly divided into two kinds, the people of experimental group 21 and the people of control group 21, experimental group carry to embodiment 1
The aerosol of confession carries out olfactory organoleptic's evaluation, and control group is to existing water base aerosol（Commercially available prod, it is fragrant containing menthol and synthesis
Essence etc.）Carry out olfactory organoleptic's evaluation；Tested using 5 scales（Enjoy a lot 2 points, typically like 1 point, no taste 0 is divided, typically
It is disagreeable -1 point, it is very disagreeable -2 points）, experimental group is equally divided into 1.52 points, and control group is 1.38 points.From the results, it was seen that
The fragrance for the aerosol that this patent provides is more easy to be received by most people.
3. sterilize effective time experiment
By to Escherichia coli（ATCC 25922）With golden yellow staphylococcus（ATCC 6538）Fungistatic effect tested, will
Bacterium is put into activation culture in 37 DEG C of liquid culture medium, and after 12 hours, 2500rpm is centrifuged 15 minutes, is washed with phosphate buffer
Dilution, then centrifuge, bacterial concentration is finally adjusted to 103cells/ml.Experimental group antibacterial is separately added into the above-mentioned bacterium solutions of 10mL
Liquid 1mL and control group antimicrobial fluid 1mL, 25 DEG C of baking ovens are interior, dark place is positioned over shaking table shaken cultivation, take 20 μ L liquid to use after 1 hour
ATP fluorescence detectors are tested, and calculate clearance.
Experimental group：The spray provided using embodiment 1 is as antiseptic.
Control group 1：The composition of antiseptic is as follows：Menthol 0.2wt%, thymol 0.2wt%, natural botanical extraction liquid（In vain
Flower pyrethrin 15wt%, Radix Sophorae Flavescentis extractive liquid 55wt%, surplus is ethylene glycol）1.0 wt%, natural plant essential oils（Citronella oil
30wt%, citral 10wt%, surplus are ethylene glycol）1.0wt%, ethylene glycol 1.0wt%, surplus are deionized water.Its preparation method
Under the conditions of 40-60 DEG C mixed liquor is mixed and made into for each raw material is fitted into vial seal.
Control group 2：The composition of antiseptic is as follows：Menthol 0.2wt%, thymol 0.2wt%, ethylene glycol 1.0wt%, surplus
For deionized water.Its preparation method is that each raw material is mixed and made into mixed liquor under the conditions of 40-60 DEG C and is fitted into vial and seals.
Experimental group and control group are open in sky in normal use 45 days, 120 days, 180 days and original product respectively
In gas bacteriostatic experiment is carried out after 4 hours and 12 hours.Its result is：
Experimental group：Normal use 45 days, Escherichia coli and golden yellow staphylococcus clearance are respectively 100% and 83.7%；Normally make
With 120 days, Escherichia coli and golden yellow staphylococcus clearance were respectively 100% and 80.3%；Normal use 180 days, Escherichia coli
It is respectively 95.2% and 76.5% with golden yellow staphylococcus clearance；Open wide and place 4 hours, Escherichia coli and golden yellow staphylococcus are gone
Except rate is respectively 77.5% and 63.9%；Open wide and place 12 hours, Escherichia coli and golden yellow staphylococcus clearance are respectively 43.9%
With 31.4%.
Control group 1：Normal use 45 days, Escherichia coli and golden yellow staphylococcus clearance are respectively 100% and 77.7%；Just
Often use 120 days, Escherichia coli and golden yellow staphylococcus clearance are respectively 98.3% and 72.1%；Normal use 180 days, large intestine
Bacillus and golden yellow staphylococcus clearance are respectively 90.6% and 63.4%；Open wide and place 4 hours, Escherichia coli and golden yellow grape
Bacterium clearance is respectively 53.9% and 40.3%；Open wide and place 12 hours, Escherichia coli and golden yellow staphylococcus clearance are respectively
32.8% and 17.3%.
Control group 2：Normal use 45 days, Escherichia coli and golden yellow staphylococcus clearance are respectively 83.5% and 65.3%；
Normal use 120 days, Escherichia coli and golden yellow staphylococcus clearance are respectively 77.8% and 62.1%；Normal use 180 days, greatly
Enterobacteria and golden yellow staphylococcus clearance are respectively 73.2% and 60.4%；Open wide and place 4 hours, Escherichia coli and golden yellow Portugal
Grape bacterium clearance is respectively 50.7% and 38.8%；Open wide and place 12 hours, Escherichia coli and golden yellow staphylococcus clearance difference
For 31.3% and 16.8%.
The aerosol that can be seen that this patent offer from above-mentioned experiment has more preferably relative to the bottled formula bactericide of routine
Fungistatic effect and the longer antibacterial shelf-life, and the data from control group 1 and control group 2 can be seen that natural botanical extraction liquid
It is easier to decompose in atmosphere with natural plant essential oils exposure.
4. desinsection and effective time experiment
Aerosol in embodiment 1-6 is made standby, 30 houseflies living, 20 culexs living are respectively put into each closed experiment
In case, using the aerosol of the present invention respectively to atomized liquid is sprayed on tank wall, spray value is 3 seconds.Start timing and timing is observed
Record knocks down number of elements after 24 hours, and the mosquitos and flies in removing case, chamber is respectively put into equal number of again after placing 24 hours
Mosquitos and flies simultaneously sprays blank control, and number of elements is knocked down after starting timing and regularly observing and recording 24 hours.Carry out blank control examination simultaneously
Test, as a result see below.Blank control formula is as follows：The mixed solvent that 6g ethylene glycol and 4g plants essential oils are formed, adds 10g hydrogen
Change castor oil（Marked as AA220）, transparency emulsion is obtained after mixing.
(2) 1g sodium benzoates and 3g natrium nitrosums are added sequentially in 680g deionized waters, obtained after mixing transparent molten
Liquid.
(3) clear solution that the transparency emulsion for obtaining step (1) obtains with step (2) loads in inhalator jar after mixing,
After aerosol valve sealed cans, 300g dimethyl ethers are added into aerosol.
As a result such as following table
Table 4
From table 4, it can be seen that excluding natural death and alcohol function, the present embodiment is effectively killed and stability can reach excellent
Insect killing effect.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (7)
1. a kind of aerosol for expelling parasite, sterilizing and mite killing, it is characterised in that by the raw material system of following weight percent content
Into：Menthol 0.1%-0.5%, thymol 0.1%-0.5%, natural botanical extraction liquid 0.5%-1.0%, natural plant essential oils 0.5%-
1.0%th, rilanit special 1.0%-1.5%, ethylene glycol 1.0%-1.5%, corrosion inhibiter 0.2%-0.5% and propellant 20%-35%, surplus
For deionized water；The natural botanical extraction liquid includes：Cinerin 0-20wt%, Radix Sophorae Flavescentis extractive liquid 5-60wt%, surplus
For ethylene glycol；The natural plant essential oils include：Citronella oil 5-40wt%, citral 5-15wt%, surplus are ethylene glycol.
2. the aerosol according to claim 1 for expelling parasite, sterilizing and mite killing, it is characterised in that by following weight hundred
The raw material than content is divided to be made：Menthol 0.2%, thymol 0.2%, natural botanical extraction liquid 1.0%, natural plant essential oils 1.0%,
Rilanit special 1.5%, ethylene glycol 1.0%, corrosion inhibiter 0.4% and propellant 30%, surplus are deionized water；The natural plants carry
Liquid is taken to include：Cinerin 15wt%, Radix Sophorae Flavescentis extractive liquid 55wt%, surplus are ethylene glycol；The natural plant essential oils include：
Citronella oil 30wt%, citral 10wt%, surplus are ethylene glycol.
3. the aerosol according to claim 1 or 2 for expelling parasite, sterilizing and mite killing, it is characterised in that the corrosion inhibiter
One or more in ring ethylamine, sodium benzoate, natrium nitrosum, ammonium benzoate and sodium molybdate.
4. the aerosol according to claim 1 or 2 for expelling parasite, sterilizing and mite killing, it is characterised in that the propellant
One or more in dimethyl ether, propane, normal butane and iso-butane.
5. the aerosol according to claim 1 or 2 for expelling parasite, sterilizing and mite killing, it is characterised in that the propellant
For dimethyl ether.
6. the aerosol according to claim 1 or 2 for expelling parasite, sterilizing and mite killing, it is characterised in that the hydrogenation castor
Sesame oil marked as AA220.
7. the preparation method of the aerosol for expelling parasite, sterilizing and mite killing as described in claim any one of 1-6, its feature exist
In the described method comprises the following steps：
(1) menthol, thymol, natural plant essential oils, natural botanical extraction liquid are added in ethylene glycol by proportioning and dissolved, then pressed
Proportioning adds rilanit special, and transparent brown emulsion is obtained after mixing；
(2) corrosion inhibiter is added in deionized water by proportioning, clear solution is obtained after mixing；
(3) after the transparent brown emulsion that step (1) obtains is mixed with the clear solution that step (2) obtains by proportioning, then by matching somebody with somebody
Aerosol is made than adding propellant.
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