CN109820739A - A kind of skin composition and its preparation method and application of Plantain skin lightening - Google Patents
A kind of skin composition and its preparation method and application of Plantain skin lightening Download PDFInfo
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Abstract
The invention discloses a kind of skin compositions of Plantain skin lightening, in the acceptable matrix of skin composition, include at least following active component: fullerene；Yeast extract and/or canaline；The water-soluble whitening agent constituted is compounded by niacinamide, small paper mulberry root extract, acetyl chitosamine, apple extract, Cortex Mori extract, camellia flower extract, tea extract, madecassoside, Chinese sumac extract, tricholoma matsutake；Safflower seed oil and/or bisabolol and/or vitamin E；Tetrahydro curcumin and/or ascorbic acid glucoside；Tetrahydro methylpyrimidine carboxylic acid；Fermentative brown rice filtrate.The present invention discloses preparation methods and application.Skin composition of the present invention not only has the function of light spot skin lightening, and its essence cream being prepared can quickly highlight the dark yellow colour of skin, Kohakuhi, the glossiness for promoting skin entirety, while also have property it is mild, it is low stimulate, the superperformances such as skin sense is soft and moist.
Description
Technical field
The present invention relates to a kind of shield skin compositions, and in particular to a kind of skin composition of Plantain skin lightening and its preparation
Methods and applications belong to cosmetic technical field.
Background technique
Asia women is " a white screening three is ugly " to the traditional concept of beauty, and determines that the color of skin is by melanin in skin
How much decisions.Melanin concentrates in the cell of the germinal layer of epidermis and iuntercellular.Typically no melanin in skin corium,
But when there is pigment, it can pass through skin and be in cyan, such as newborn's sacrum portion and the spot of buttocks ash cyan.In addition, the color of skin
It is also related with the degree of roughness of blood, skin in capilary and wet degree.Spot is light brown fleck, and needle point is big to the grain of rice
It is small, forehead, the bridge of the nose, cheek etc. are often come across, also appears in neck, the back of the hand etc. once in a while.I.e. melanin is non-uniform is distributed in
On skin.
The synthesis of melanin has 3 kinds of necessary materials: tyrosine (primary raw material of manufacture melanocyte)；Tyrosinase (tyrosine
It is transformed into the major rate-limiting enzyme of melanocyte, is the composition of copper and protein)；(tyrosine generates oxygen under the action of tyrosinase
Melanocyte, the reaction are oxidation process, it is necessary to can just be reacted in conjunction with oxygen).The melanin genesis approach generally acknowledged at present: tyrosine
3,4- dihydroxy propyl benzene propylhomoserin, that is, DOPA is generated under tyrosinase catalysis, DOPA, which further aoxidizes, generates DOPA quinone.DOPA quinone
Dopachrome is generated with oxidation reaction through multimerization reaction, dopachrome hydroxylation is 5,6- bis- under dopachrome color structure enzyme effect
Oxyindole carboxylic acid (DHICA), 5,6- dihydroxy indole carboxylic acid (DHICA) decarboxylations are at 5,6 dihydroxy indoles, 5,6 dihydroxy Yin
Diindyl is oxidized to 5,6- istain under tyrosinase catalysis again, and 5,6- istains finally form in conjunction with other intermediate products very black
Pigment.The formation of de- melanin, preceding part is consistent with eumelanin to DOPA quinone by tyrosine, but afterwards, has in reaction
Cysteine (Cys) participates in generation Cys- DOPA and Cys- DOPA quinone passes through cyclization decarboxylation.Eventually form de- melanin.Melanin
Synthesis occur in melanocyte this be a kind of cell from neural ridge.The specific cells of melanocyte synthesis of melanin
Device is melanosome.Melanin generate after be accumulated into pigment granule by skin epithelial cells (both it can be seen that composition skin
The cell of skin epidermis) phagocytosis is evenly distributed in our skin in skin epidermis and " caught " the different face of the depth like this
Color.
From the forming process of melanin, it is desirable to which tyrosinase activity inhibitor, melanin can be selected in whitening and light spot
The methods of cytotoxic agent, influence melanin metabolism agent, opacifier, reducing agent and Chemical peeling agent reach Whitening, spot effect.
Tyrosinase is a kind of metalloenzyme for being widely present in cupric in animal and plant body and microorganism, it have monophenolase and
Diphenol enzyme viability is the key enzyme of organism synthesis of melanin.By inhibiting the activity of tyrosinase that can inhibit melanin
Generation, this is also one of the predominating path for reaching Whitening, spot at present.Thus tyrosinase inhibitor is widely used in
Cosmetics and pharmaceuticals industry are as skin whitener, and in food service industry as anti-browning preservative.Currently used junket ammonia
Phytase activity inhibitor has: arbutin, niacinamide, glabridin, licoflavone, VC and its derivative etc..
Skin-care product are almost impossible blotch removal on the face, its effect is that melanin is allowed to disperse more equal
It is even, it allows pigment granule to decompose more fine crushing and inhibits melanin production, it is final the result is that spot is enabled to desalinate, enable spot generate
Probability is reduced, thus allow face seem more evenly, it is bright.
Summary of the invention
To solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of skin compositions of light spot skin lightening.
Skin composition of the present invention may include active constituent of the present invention and other of the present invention group
Point, or be grouped as by these groups or be substantially grouped as by these groups, " being substantially grouped as by these groups " refers to this
The invention skin composition can also include other components, as long as the other components will not change the present invention and be wanted significantly
Ask the skin composition of protection or the basic characteristic of preparation method.
" skin care " of the present invention refers to improving the situation of skin, such as: enhancing skin elasticity, whitening, nti-freckle.
In addition, heretofore described " skin composition is acceptable " refers to that skin composition of the present invention is suitable
For contacting with human skin, and toxicity, incompatibility, unstability and allergic reaction etc. will not be generated to human body.
In order to achieve the above objectives, the present invention uses following specific technical solution:
A kind of skin composition of Plantain skin lightening includes at least following active group in the acceptable matrix of skin composition
Point, and the additional amount of the active component is in terms of skin composition total weight percent:
(1) radicals scavenging and cell factor constituents for suppressing: fullerene 1-10ppm；
(2) yeast extract 0.2-3%, canaline 0.2-3% skin repair component: are selected from；
(3) water-soluble whitening agent: by niacinamide 0.5-5%, small paper mulberry root extract 0.05-0.5%, acetyl chitosamine 0.2-3%,
Apple extract 0.05-0.5%, Cortex Mori extract 0.05-0.5%, camellia flower extract 0.05-0.5%, tea extract
0.05-0.5%, madecassoside 0.05-0.5%, Chinese sumac extract 0.05-0.5%, tricholoma matsutake 0.05-0.5%
Compounding is constituted；
(4) safflower seed oil 0.4-3%, bisabolol 0.05-0.5%, vitamin E 0.1% plant whitening oil: are selected from；
(5) tyrosinase activity inhibitor: it is selected from tetrahydro curcumin 0.1-1% and ascorbic acid glucoside 0.1-2%；
(6) Facultative Halophiles extract liquor: tetrahydro methylpyrimidine carboxylic acid 0.2%；
(7) moisturizing component: fermentative brown rice filtrate 3-15%.
In above-mentioned active component,
Fullerene: the football shaped molecule being made of 60 or more carbon atoms has perfect structure.It is earliest by scientist
Found in the interstellar dust in cosmic space, thus be referred to as " present of god ", after also have a small amount of discovery in nature.Yin Fu
Strangling alkene has extremely extensive purposes and splendid performance, therefore " Nobel's chemistry in 1996 is awarded in three finders
Prize ".Fullerene is all the substance being made of same simple substance carbon as diamond, is the third homoatomic that simple substance carbon is found
Obform body.About fullerene it is anti-oxidant in terms of, mainly have a two big mechanism, first, participate in superoxide anion and hydrogen peroxide
Catalysis metabolism, the electronics of superoxide anion can be shifted, reduce damage of the free radical to body, and itself is by broken
It is bad；Second, it can also generate corresponding derivative with excessive radical reaction, and achieve the effect that remove free radical.Because of it
Free radical scavenging ability with super strength, and it is referred to as " free radical sponge ".In addition, fullerene can also be by inhibiting various cells
The factor, inflammatory factor etc. participate in the intracorporal metabolism of biology.It has been investigated that the oxidation resistance of discovery fullerene is the 172 of Vc
Times, fullerene is sustainable to play superpower free radical scavenging activity, and itself is without damage, and under the conditions of ultraviolet light, still
It can continue to play antioxidation；Have the effect of extending cell survival, improves the content of collagen in skin.Fullerene is not
Be only capable of inhibiting skin surface free radical caused by by UVA/UVB generate and the damage of resisting it to skin, and become it is coarse and
Erythema is generated, may also suppress UV to deep skin structural damage, such as I, type Ⅳ collagen albumen.By remove free radical and
Inhibit cell factor and realizes.The generation for obviously inhibiting intracellular PEG-2, the fullerene for adding 2.5ppm can make carefully
The horizontal decline 72% of PEG-2 intracellular, this illustrates that fullerene can realize white-skinned face function by lowering PEG-2 level.
Yeast extract and canaline (DermalRx SRC): U.S. Biocogent passes through by viral (phagocytosis
Body is shown) technology, filter out the molecule that diagonalization layer chymotrypsin (SCCE, also referred to as KLK7) has affinity.Through proprietary wine brewing
Yeast strain grows in the culture medium of amino acid and specific carbohydrate, to obtain pure Yeast Cultivation product.Normally
The healthy skin cell turnover period need about 4 weeks, the update (exfoliating) of skin be by disconnection aging cutin iuntercellular
Attachment complete, horn cell is linked together by a kind of cutin desmosome of protein combination, and cutin desmosome is because of skin sheet
The enzyme (KLK's) of body and constantly degenerate, thus promote decortication and skin renewal.Enzyme of the DermalRx SRC to cutin desmosome
With affinity, and then accelerate falling off for cuticula, accelerates the update of skin, cuticula falls off, the melanocyte on cuticula
Grain is driven to fall off together.
Water-soluble whitening agent: it is combined natural origin product WhiteTen SL by ten kinds of water-soluble whitening compositions.Korea Spro
BIOSPECTRUM company, state has chosen this by niacinamide, small paper mulberry root by each effect stepwise factor of research melanin genesis
Extract, acetyl chitosamine, apple extract, Cortex Mori extract, camellia flower extract, tea extract, madacasso grass
Ten kinds of glucoside, Chinese sumac extract, tricholoma matsutake natural origins compound, each stage of black synthesis is carried out effective
Inhibition.Niacinamide is also referred to as niacinamide or 3-pyridinecarboxamide, ferments from yeast.Vitamin B3
Or nicotinic acid, it is a kind of water soluble vitamin, belongs to B family vitamin, is cozymase (nicotinamide adenine dinucleotide, NAD)
With the constituent of codehydrogenase Ⅱ (nicotinamide-adenine dinucleotide phosphate, NADP), in human body in both coenzyme structures
Nicotinoyl amine moiety adds hydrogen and dehydrogenation characteristic with reversible, plays in biological oxidation and passs hydrogen effect, can promote tissue respiration, life
Object oxidation process and metabolism have weight to the integrality for maintaining normal tissue especially skin, alimentary canal and nervous system
Want meaning.The content of the skin NADH and NADPH of aging increasingly decay, and the two controls the intracellular full mistake synthesized and decompose
Journey.Precursor of the niacinamide as NADH and NADPH can be played a role by adjusting the internal horizontal balance of the two.It is high-caliber
NADPH plays powerful antioxidation, prevents protein and sugar that spontaneous glycosylation occurs.What glycosylation generated
Glycated protein is deposited on corium and shows yellowish-brown.Impaired Stratum corneum lipids barrier can also be repaired, skin resistance is improved.
The generation of fatty acid and triglycerides in sebum can also be reduced, to receive fine, soft fur hole and reduce serious journey when acne occurs
Degree.
Acetyl chitosamine inhibits to generate active tyrosine enzyme, to prevent induction melanin production.Tyrosinase initially exists
It is inactive state in cell, but becomes active form after being glycosylated.It glycosylates the activity for inhibiting enzyme by inhibiting,
To reduce melanin.Madecassoside is inhibited in a manner of dose-dependent, the generation to melanin caused by α-MSH,
And do not have cytotoxicity.Human melanocyte synthesis of melanin is effectively reduced in the madecassoside of 50 ppm, and amount is up to
20%。
Colourless, white powder is obtained after paper mulberry bark is dry, odorlessness is inhibited to B16 cell, also has
There is good anti-oxidant, anti-inflammatory effect.
Matsutake, scientific name Trichotoma matsutake, alias pine mushroom, combined bacteria, Tricholoma matsutake (lto et lmai) singer are subordinate to Basidiomycotina, Tricholomataceae, are the trees such as loose oak
External mycorrhizal fungi has unique strong fragrance, is rare rare natural medicinal bacteria in the world.Matsutake extracts significant suppression
The generation of B16 melanin processed.
Chinese sumac also known as Chinese gall tree, root, leaf, flower and fruit can be used as medicine, and have clearing heat and detoxicating, relaxing tendons and activating collaterals, the scattered stasis of blood to stop
The benefits of blood, relieving diarrhea with astringents.Chinese sumac extract has good anti-oxidant, antiviral, antibacterial, antitumaous effect.
Green-tea extract main active ingredient tea polyphenols and caffeine.With potent antioxidants, in green tea polyphenols energy
And free radical, it is possible to reduce or prevent damage caused by free radical.To the inhibiting effect of tyrosinase, acted on skin-whitening
It is closely related.Green tea polyphenols reach 45.2% in 100ppm concentration, to the inhibiting effect of tyrosinase.
Small paper mulberry is Moraceae paper mulberry category, machaka.Branch extend significantly and in overgrowing, it is 0.5-3 meters high；Sprig is hairless.
Ingredient on white-skinned face function has KazinolA, KazinolB, KazinolF.Kazinol F (Paper Mulberry) is mentioned
Object is taken to inhibit tyrosinase activity.
Winter cypress also known as camellia, it is a member of Theaceae family.Camellia flower extract is in DPPH and ABTS analysis
Show excellent antioxidation.Also have and inhibits inflammatory factor Nitric Oxide and Eotaxin-1 and reduction ring
The expression of oxygenase.Apple extract contains natural polyphenol substance, it may have inhibits the synthesis of melanin.
WhiteTen SL has efficient white-skinned face function, is each stage by inhibiting melanin production mechanism, rises
To good synergistic effect.It is able to suppress the expression of IL-4 induction Eotaxin-1 and fibroblasts of adult human dermis is stimulated to be proliferated.
Plant whitening oil: safflower seed oil, bisabolol, vitamin E are selected from, wherein safflower seed oil sub- oil rich in
Acid and vitamin E.The content of Linoleic Acid in Safflower Oil >=67.8%(national standard minimum standard), Linoleic Acid in Safflower Oil contains
Amount is that content is highest in known plants, therefore is known as " king of linoleic acid ".Linoleic acid is the constituent of cell, especially
It is the synthesis for participating in mitochondria and cell membrane phosphorus matter.Linoleic acid shortage may cause mitochondrial swelling, cell membrane mechanism, function
Change, membrane permeability, brittleness increase.The material for forming cell membrane is exactly unsaturated fatty acid.Linoleic acid has reinforcing metabolism, increases
The function of strong cell viability.Natural VE is rich in safflower seed oil, average content is in all plants in 800mgDL or so
Content is highest, therefore safflower is known as " hat of vitamin E ".Vitamin E in safflower seed oil be it is pure natural, have life
Active natural VE.Vitamin E is a kind of very strong reducing agent, has extremely strong antioxidation.There are also anti-agings for it
Effect, so that aging, the cell of aging and tissue is got increasingly vigorous.Vitamin E be it is a kind of can improve the immunity of the human body, eliminate freely
Base, the nutriment of pre- anti-cancer.ɑ-the bisabolol (ɑ-bisabolol 80 ~ 90%) in the oily source of Ka Deya tree, to melanocyte
There are apparent white-skinned face function and no cytotoxicity.Not only there is anti-inflammatory performance, be also proved to have bacteriostatic activity.
Tetrahydro curcumin: tetrahydro curcumin is by the curcumin isolated in zingiberaceous plant turmeric (curcumalonga) rhizome
(curcumin) it hydrogenates.Japan plus the long Feng Faxian of rattan have very excellent inhibition tyrosine with the ginger phenolic compounds of carboxylic acid
Enzymatic activity.Tetrahydro curcumin has the potent activities for inhibiting tyrosinase, and whitening effect is better than arbutin；Oxygen can effectively be inhibited certainly
The free radical formed simultaneously can be removed by the generation of base (oxygenfreeradicals), there is apparent antioxidation,
Such as human body skin aging, reparation, desalination pigment, nti-freckle；Also there is anti-oxidant, antitumor and study of anti-atherogenic effect
And it is used for novel medical material and intermediate.
Ascorbic acid glucoside: English name is Ascorbyl Glucoside, is also Ascorbic acid 2-
Glucoside(AA2G).It is ascorbic derivative, contains glucose stable elements.So that vitamin C can be convenient and have
Effect ground manufacture cosmetics, creams and lotion containing AA2G are used for skin, by the effect of enzyme and alpha-glucosidase on skin,
Vitamin C contained by AA2G can slowly come out.AA2G can be used to desalinate the colour of skin, and the pigment for reducing senile plaque and freckle is heavy
It forms sediment.AA2G is applied not only to whitening, while can also highlight the dull colour of skin, delays senescence, protection skin is played in sunscreen product
Effect.
Tetrahydro methylpyrimidine carboxylic acid: tetrahydro methylpyrimidine carboxylic acid also known as Ectoin (Ecoin) derive from high Halophiles
(Halomonas Elongata), therefore also it is called " Facultative Halophiles extract liquor ".1985, Professor Galinski existed
Egyptian desert discovery desert Halophiles * is in high temperature, and dry, strong UV irradiates, and under high salinity environment, can generate one in cellulosa
The natural protective ingredient of kind.Halophiles is bred by biofermentation technique, is carrying out collecting newborn program, Halophiles is under good environment
Fall off tetrahydro methylpyrimidine carboxylic acid, then carries out multi-section and purify to obtain the tetrahydro methylpyrimidine carboxylic acid starting material of white powder high-purity
Finished product.Tetrahydro methylpyrimidine carboxylic acid in cell film layer reduces the second messenger that sunburn induces, and (second messenger refers to be generated into the cell
Non-protein micromolecular can induce a series of protein phosphorylations, finally cause cytological effect by activated protein kinase) it is raw
At；The AP-2(transcription factor-2 evoked by sunburn is reduced in cellular plasm layer, is a kind of DNA binding protein of special serial number,
Can selectively be expressed with induction virus and cell enhancing original part interaction, stimulated gene) activity；It reduces and shines in nucleus
The generation of anticusp inflammation factor (anticusp inflammation factor can lead to the cell factor such as interleukin 1 for generating inflammation) after wound.Tetrahydro
Methylpyrimidine carboxylic acid plays good after-sun recovery effect to cell membrane, plasm and the multi-faceted influence of nucleus, can hinder
Only because of caused chain reaction of tanning severely, the induced mt-DNA mutation of prevention sunburn.And skin epidermis can also be protected
(langerhans' cells Langerhans Cells is important immune thin of skin to langerhans' cells between horn cell
Born of the same parents) cause to injure and reach enhancing skin immune system from environmental stimuli.Drawing because ultraviolet light irradiates for 80-90% can be reduced
The formation of the sunburn cell risen.
Fermentative brown rice filtrate: brown rice is a kind of Wholegrain rice with complete vitality, dietary fiber rich in,
Functional active components and minerals can improve cell viability and immune function of human body.Selected saccharomycete is as fermenting microbe, brown rice
It ferments as main substrate.Nutriment after fermentation in brown rice is fully discharged, converted and is enriched with.Fermentative brown rice
In filtrate polypeptide, amino acid, antiactive oxygen phytic acid, ferulic acid, lactic acid, plant amide and sterol isoreactivity rich at
Point.These active constituent energy deep layers nourish skin, inject vigour into for skin cell, the damage for effectively promoting skin cell is repaired
It is multiple, aging is resisted, and it is obscure to improve skin, keeps skin water profit beautiful.
Seven kinds described above are chosen the natural products functional component come, and are set about from each stage for inhibiting melanin to be formed,
Multipath is taken to reach light spot skin lightening result.
Further, above-mentioned plant whitening oil can also include peony seed oil, and the additional amount of the peony seed oil can
Think the 1-3% of skin composition total weight.
And above-mentioned yeast extract is then preferably the derivative oligopeptides of biofermentation.It is further preferred that above-mentioned skin is repaired
Multiple component is compounded by the derivative oligopeptides of biofermentation and canaline.
The preferred technical solution of the present invention other one are as follows:
The skin composition of Plantain skin lightening, including following components, and the additional amount of each component is with skin composition total weight
Percentages: fullerene 1-10ppm, ascorbic acid glucoside 0.1-2%, fermentative brown rice filtrate 3-15%, tetrahydro curcumin 0.1-
1%, tetrahydro methylpyrimidine carboxylic acid 0.2%, hydrolysis Sodium Hyaluronate 0.1%, Sodium Hyaluronate 0.05%, peony seed oil 1-3%, safflower
Seed oil 0.4-3%, bisabolol 0.05-0.5%, vitamin E 0.1%, yeast extract 0.2-3%, canaline 0.2-3%,
Niacinamide 0.5-5%, small paper mulberry root extract 0.05-0.5%, acetyl chitosamine 0.2-3%, apple extract 0.05-0.5%, mulberry
Bark extract 0.05-0.5%, camellia flower extract 0.05-0.5%, tea extract 0.05-0.5%, madecassoside
0.05-0.5%, Chinese sumac extract 0.05-0.5%, tricholoma matsutake 0.05-0.5%, butanediol 3%, propylene glycol 2%, 1,2-
Pentanediol 0.5%, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers 0.5%, hydrolecithin 0.2%, to hydroxyl
Acetophenone 0.2%, decoyl hydroximic acid 0.1%, glycerol caprylate 0.1%, disodium ethylene diamine tetraacetate 0.02%, surplus are water.
Equally, in above-mentioned preferred embodiment, the yeast extract is the derivative oligopeptides of biofermentation.
Another goal of the invention of the present invention is to provide a kind of preparation method of the skin composition of Plantain skin lightening, according to each component
Weight percent in skin composition, is prepared by following steps:
S1: by butanediol, hydrolysis Sodium Hyaluronate, Sodium Hyaluronate, disodium ethylene diamine tetraacetate, ascorbic acid glucoside, four
Hydrogen methylpyrimidine carboxylic acid, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers are added in emulsion pot, and stirring is warming up to
80-85 DEG C, 10 minutes are kept the temperature to being uniformly dispersed within stirring homogeneous 3 minutes；
S2: oily phase pot is added in hydrolecithin, safflower seed oil, bisabolol, vitamin E, peony seed oil, stirring is warming up to
75-80 DEG C extremely melts；
S3: emulsion pot extracts vacuum, and oily phase pot Material is pumped into emulsion pot, keeps the temperature 10 points to emulsifying completely within stirring homogeneous 5 minutes
Clock；
S4: emulsion pot stirring is cooled to 45 DEG C hereinafter, 1,2- pentanediol, parahydroxyacet-ophenone, the decoyl hydroxyl oxime that will have been melted in advance
Emulsion pot is added in acid, glycerol caprylate；Emulsion pot is added in the propylene glycol melted in advance, tetrahydro curcumin；Again by fermentative brown rice
Filtrate, fullerene solution, yeast extract, canaline and niacinamide, small paper mulberry root extract, acetyl chitosamine, apple
Fruit berry extract, Cortex Mori extract, camellia flower extract, tea extract, madecassoside, Chinese sumac extract,
Emulsion pot is added in the compound water-soluble whitening agent of ten kinds of raw materials of tricholoma matsutake；Stirring 10 minutes to being uniformly dispersed；
S5:38 DEG C or less sample detection physical and chemical index, it is qualified after filtering and discharging, obtain the skin composition of Plantain skin lightening.
A kind of skin composition for the Plantain skin lightening that above-mentioned preparation method is prepared is preparing answering in skin care item
It using form is lotion, frost, cream, any form in aqua with, skin care item.
The invention has the beneficial effects that: skin composition of the present invention not only has the function of light spot skin lightening, and
Its essence cream being prepared can quickly highlight the dark yellow colour of skin, Kohakuhi, promote the glossiness of skin entirety, while also have
The superperformances such as property is mild, low stimulation, skin sense are soft and moist.
Specific embodiment
Below in conjunction with detailed description of the invention by specific embodiments.
Percentage involved in following embodiment is the total weight according to composition.
Embodiment 1: preparation essence cream.
The raw material of moisturizing lotion forms are as follows: fullerene 2ppm, ascorbic acid glucoside 0.2%, fermentative brown rice filtrate 5%, four
Hydrogen curcumin 0.2%, tetrahydro methylpyrimidine carboxylic acid 0.2%, hydrolysis Sodium Hyaluronate 0.1%, Sodium Hyaluronate 0.05%, peony seed oil
2%, the derivative oligopeptides 0.2% of safflower seed oil 1%, bisabolol 0.1%, vitamin E 0.1%, biofermentation, canaline 0.2%,
Niacinamide 2%, small paper mulberry root extract 0.05%, acetyl chitosamine 0.2%, apple extract 0.05%, Cortex Mori extract 0.05%
, camellia flower extract 0.05%, tea extract 0.05%, madecassoside 0.05%, Chinese sumac extract 0.05%, become less severe
Mushroom extract 0.05%, butanediol 3%, propylene glycol 2%, 1,2- pentanediol 0.5%, hydroxy-ethyl acrylate/acryloyldimethyl ox sulphur
Sour sodium copolymer 0.5%, hydrolecithin 0.2%, parahydroxyacet-ophenone 0.2%, decoyl hydroximic acid 0.1%, glycerol caprylate 0.1%,
Disodium ethylene diamine tetraacetate 0.02%, surplus are water.
The raw material composition of the essence of embodiment 2 and embodiment 3 cream is same as Example 1, only difference is that raw material group
Cheng Zhong, fullerene, ascorbic acid glucoside, fermentative brown rice filtrate, tetrahydro curcumin, peony seed oil, safflower seed oil, opopanax
Alcohol, yeast extract, canaline, niacinamide, small paper mulberry root extract, acetyl chitosamine, apple extract, paper mulberry bark mention
Take object, camellia flower extract, tea extract, madecassoside, Chinese sumac extract, tricholoma matsutake.
Embodiment 2: fullerene 5ppm, ascorbic acid glucoside 1.2%, fermentative brown rice filtrate 10%, tetrahydro curcumin 0.9%,
Peony seed oil 1%, safflower seed oil 3%, bisabolol 0.3%, biofermentation derivative oligopeptides 2.8%, canaline 1.5%, niacinamide
2%, small paper mulberry root extract 0.25%, acetyl chitosamine 1.5%, apple extract 0.2%, Cortex Mori extract 0.15%, camellia
Flower extract 0.45%, tea extract 0.15%, madecassoside 0.25%, Chinese sumac extract 0.25%, Trichotoma matsutake extract
Object 0.25%.
Embodiment 3: fullerene 10ppm, ascorbic acid glucoside 1.8%, fermentative brown rice filtrate 15%, tetrahydro curcumin
0.6%, the derivative oligopeptides 1.5% of peony seed oil 3%, safflower seed oil 0.5%, bisabolol 0.5%, biofermentation, canaline 3%,
Niacinamide 5%, small paper mulberry root extract 0.5%, acetyl chitosamine 3%, apple extract 0.45%, Cortex Mori extract 0.5%, mountain
Flos Camelliae Japonicae extract 0.15%, tea extract 0.45%, madecassoside 0.5%, Chinese sumac extract 0.5%, Trichotoma matsutake extract
Object 0.45%.
The preparation method of embodiment 1-3 is identical, are as follows: first by butanediol, hydrolysis Sodium Hyaluronate, Sodium Hyaluronate,
Disodium ethylene diamine tetraacetate, ascorbic acid glucoside, tetrahydro methylpyrimidine carboxylic acid, hydroxy-ethyl acrylate/acryloyldimethyl ox
Sodium sulfonate copolymers are added in emulsion pot, and stirring is warming up to 80-85 DEG C, keep the temperature 10 points to being uniformly dispersed within stirring homogeneous 3 minutes
Clock；Then oily phase pot is added in hydrolecithin, safflower seed oil, bisabolol, vitamin E, peony seed oil, stirring is warming up to
75-80 DEG C extremely melts；Emulsion pot is extracted into vacuum again, oily phase pot Material is pumped into emulsion pot, stirring homogeneous 5 minutes is to having emulsified
Entirely, 10 minutes are kept the temperature；Then, emulsion pot stirring is cooled to 45 DEG C hereinafter, by 1, the 2- pentanediol melted in advance, para hydroxybenzene second
Emulsion pot is added in ketone, decoyl hydroximic acid, glycerol caprylate；Emulsion pot is added in the propylene glycol melted in advance, tetrahydro curcumin；Again
By fermentative brown rice filtrate, fullerene solution, yeast extract, canaline and niacinamide, small paper mulberry root extract, acetyl
Chitosamine, apple berry extract, Cortex Mori extract, camellia flower extract, tea extract, madecassoside, salt skin
Emulsion pot is added in the compound water-soluble whitening agent of ten kinds of wooden extract, tricholoma matsutake raw materials；Stirring 10 minutes equal to dispersing
It is even；Finally, 38 DEG C or less sample detection physical and chemical indexes, it is qualified after filtering and discharging, obtain the essence cream of Plantain skin lightening.
It is preferred embodiment with embodiment 2, and carries out both effectiveness test using the preparation-obtained essence cream of embodiment 2.
The specific testing process of both effectiveness test are as follows:
1, object and method:
1.1 objects: random, open, Self-controlled study is taken.Guangzhou different regions office building office staff 50 is chosen,
All testers are undesirable to oneself current colour of skin or face's spottiness.All voluntary participation clinical observers are signed and know together
Meaning book, and promise to undertake as required using light spot skin lightening essence cream.
Inclusion criteria: 1. continue the previous normal work and life state of individual before clinical observation in 1 week, and observing
Period does not use the said goods or similar product；2. not indulging in excessive drinking during observation, excessive maror is not eaten；3. during observation not
Use other skin care item and dermatologic.
1.2 methods:
1.2.1 test method:
Control group conventionally, patient daily sooner or later twice, by Irrigation it is clean after light spot skin lightening essence cream is uniformly applied to
Affected part continues 30 days.
1.2.2 evaluation method:
Effective: the colour of skin, which has, obviously to be highlighted or the desalination of face's spot, skin become fine and smooth, water profit, and skin water and oil balance, gloss has life
Gas, chloasma, color spot have certain desalination, and skin lines shoal；
It is invalid: the colour of skin continue it is obscure, dry skin or it is greasy, pore is coarse, microgroove is obvious, and color spot is obvious unchanged etc..
Statistical method data use SPSS13.0 software row Wilcoxon rank sum test, inspection level a==0.05.
2, result:
Effective 48, it is 2 invalid, effective percentage be 96%.
Adverse reaction: during using essence cream of the present invention, do not occur adverse reaction, patient reflects this essence
Newborn skin sense is good, and without irritation and uncomfortable feeling, all patients complete entire experiment.
Through the above test results, we can know that: not only the essence cream with light spot skin lightening can quickly highlight the dark yellow colour of skin, desalination
Spot, the glossiness for promoting skin entirety, also have property it is mild, it is low stimulate, the superperformances such as skin sense is soft and moist.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the above embodiments do not limit the invention in any form, all obtained by the way of equivalent substitution or equivalent transformation
Technical solution is fallen within the scope of protection of the present invention.
Claims (8)
1. a kind of skin composition of Plantain skin lightening, which is characterized in that in the acceptable matrix of skin composition, at least wrap
Following active component is included, and the additional amount of the active component is in terms of skin composition total weight percent:
(1) radicals scavenging and cell factor constituents for suppressing: fullerene 1-10ppm；
(2) yeast extract 0.2-3%, canaline 0.2-3% skin repair component: are selected from；
(3) water-soluble whitening agent: by niacinamide 0.5-5%, small paper mulberry root extract 0.05-0.5%, acetyl chitosamine 0.2-3%,
Apple extract 0.05-0.5%, Cortex Mori extract 0.05-0.5%, camellia flower extract 0.05-0.5%, tea extract
0.05-0.5%, madecassoside 0.05-0.5%, Chinese sumac extract 0.05-0.5%, tricholoma matsutake 0.05-0.5%
Compounding is constituted；
(4) safflower seed oil 0.4-3%, bisabolol 0.05-0.5%, vitamin E 0.1% plant whitening oil: are selected from；
(5) tyrosinase activity inhibitor: it is selected from tetrahydro curcumin 0.1-1% and ascorbic acid glucoside 0.1-2%；
(6) Facultative Halophiles extract liquor: tetrahydro methylpyrimidine carboxylic acid 0.2%；
(7) moisturizing component: fermentative brown rice filtrate 3-15%.
2. a kind of skin composition of Plantain skin lightening according to claim 1, which is characterized in that the plant whitening
Oil further includes peony seed oil, and the additional amount of the peony seed oil is the 1-3% of skin composition total weight.
3. a kind of skin composition of Plantain skin lightening according to claim 1, which is characterized in that the yeast extracts
Object is the derivative oligopeptides of biofermentation.
4. a kind of skin composition of Plantain skin lightening according to claim 1, which is characterized in that the skin repair
Component is compounded by the derivative oligopeptides of biofermentation and canaline.
5. a kind of skin composition of Plantain skin lightening, which is characterized in that including following components, and the additional amount of each component with
Skin composition total weight percent meter: fullerene 1-10ppm, ascorbic acid glucoside 0.1-2%, fermentative brown rice filtrate 3-
15%, tetrahydro curcumin 0.1-1%, tetrahydro methylpyrimidine carboxylic acid 0.2%, hydrolysis Sodium Hyaluronate 0.1%, Sodium Hyaluronate 0.05%,
Peony seed oil 1-3%, safflower seed oil 0.4-3%, bisabolol 0.05-0.5%, vitamin E 0.1%, yeast extract 0.2-3%,
Canaline 0.2-3%, niacinamide 0.5-5%, small paper mulberry root extract 0.05-0.5%, acetyl chitosamine 0.2-3%, apple mention
Take object 0.05-0.5%, Cortex Mori extract 0.05-0.5%, camellia flower extract 0.05-0.5%, tea extract 0.05-
0.5%, madecassoside 0.05-0.5%, Chinese sumac extract 0.05-0.5%, tricholoma matsutake 0.05-0.5%, fourth two
Alcohol 3%, propylene glycol 2%, 1,2- pentanediol 0.5%, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers 0.5%, hydrogenation
Lecithin 0.2%, parahydroxyacet-ophenone 0.2%, decoyl hydroximic acid 0.1%, glycerol caprylate 0.1%, disodium ethylene diamine tetraacetate
0.02%, surplus is water.
6. a kind of skin composition of Plantain skin lightening according to claim 4, the yeast extract is biology hair
Ferment derives oligopeptides.
7. a kind of preparation method of the skin composition of Plantain skin lightening described in claim 5 or 6, which is characterized in that according to
Weight percent of each component in skin composition, is prepared by following steps:
S1: by butanediol, hydrolysis Sodium Hyaluronate, Sodium Hyaluronate, disodium ethylene diamine tetraacetate, ascorbic acid glucoside, four
Hydrogen methylpyrimidine carboxylic acid, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers are added in emulsion pot, and stirring is warming up to
80-85 DEG C, 10 minutes are kept the temperature to being uniformly dispersed within stirring homogeneous 3 minutes；
S2: oily phase pot is added in hydrolecithin, safflower seed oil, bisabolol, vitamin E, peony seed oil, stirring is warming up to
75-80 DEG C extremely melts；
S3: emulsion pot extracts vacuum, and oily phase pot Material is pumped into emulsion pot, keeps the temperature 10 points to emulsifying completely within stirring homogeneous 5 minutes
Clock；
S4: emulsion pot stirring is cooled to 45 DEG C hereinafter, 1,2- pentanediol, parahydroxyacet-ophenone, the decoyl hydroxyl oxime that will have been melted in advance
Emulsion pot is added in acid, glycerol caprylate；Emulsion pot is added in the propylene glycol melted in advance, tetrahydro curcumin；Again by fermentative brown rice
Filtrate, fullerene solution, yeast extract, canaline and niacinamide, small paper mulberry root extract, acetyl chitosamine, apple
Fruit berry extract, Cortex Mori extract, camellia flower extract, tea extract, madecassoside, Chinese sumac extract,
Emulsion pot is added in the compound water-soluble whitening agent of ten kinds of raw materials of tricholoma matsutake；Stirring 10 minutes to being uniformly dispersed；
S5:38 DEG C or less sample detection physical and chemical index, it is qualified after filtering and discharging, obtain the skin composition of Plantain skin lightening.
8. a kind of skin composition for the Plantain skin lightening that preparation method as claimed in claim 7 is prepared is preparing skin care item
In application, the skin care item are lotion, frost, cream, any form in aqua using form.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106580797A (en) * | 2016-12-30 | 2017-04-26 | 广州科盈化妆品有限公司 | Whitening and freckle-removing cream and preparation method thereof |
| CN107998016A (en) * | 2017-12-11 | 2018-05-08 | 百朗德生物化学(海门)有限公司 | A kind of cosmetic material composition with freckle removing and whitening |
| CN108324633A (en) * | 2018-03-01 | 2018-07-27 | 华熙福瑞达生物医药有限公司 | A kind of preparation method and products thereof of fermentative brown rice stoste used for cosmetic |
| CN108379213A (en) * | 2016-12-14 | 2018-08-10 | 天津强微特生物科技有限公司 | A kind of moisture-keeping crease-shedding hand lotion |
| CN108652994A (en) * | 2018-08-03 | 2018-10-16 | 广东丸美生物技术股份有限公司 | A kind of skin matrix and its preparation method and application with moisturizing, improvement wrinkle and anti-oxidation efficacy |
-
2018
- 2018-11-27 CN CN201811423171.XA patent/CN109820739A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379213A (en) * | 2016-12-14 | 2018-08-10 | 天津强微特生物科技有限公司 | A kind of moisture-keeping crease-shedding hand lotion |
| CN106580797A (en) * | 2016-12-30 | 2017-04-26 | 广州科盈化妆品有限公司 | Whitening and freckle-removing cream and preparation method thereof |
| CN107998016A (en) * | 2017-12-11 | 2018-05-08 | 百朗德生物化学(海门)有限公司 | A kind of cosmetic material composition with freckle removing and whitening |
| CN108324633A (en) * | 2018-03-01 | 2018-07-27 | 华熙福瑞达生物医药有限公司 | A kind of preparation method and products thereof of fermentative brown rice stoste used for cosmetic |
| CN108652994A (en) * | 2018-08-03 | 2018-10-16 | 广东丸美生物技术股份有限公司 | A kind of skin matrix and its preparation method and application with moisturizing, improvement wrinkle and anti-oxidation efficacy |
Cited By (19)
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| CN110237018A (en) * | 2019-07-31 | 2019-09-17 | 东晟源研究院(广州)有限公司 | The Recipe and preparation method of various dimensions speckle removing, acne removing print and even skin tone |
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