CN114288203A - Novel skin care lotion for stabilizing vitamin c - Google Patents
Novel skin care lotion for stabilizing vitamin c Download PDFInfo
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- CN114288203A CN114288203A CN202210046898.0A CN202210046898A CN114288203A CN 114288203 A CN114288203 A CN 114288203A CN 202210046898 A CN202210046898 A CN 202210046898A CN 114288203 A CN114288203 A CN 114288203A
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- vitamin
- skin care
- resveratrol
- tetrahydrocurcumin
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 124
- 229960005070 ascorbic acid Drugs 0.000 title claims abstract description 47
- 230000000087 stabilizing effect Effects 0.000 title claims abstract description 15
- 239000006210 lotion Substances 0.000 title claims description 26
- LBTVHXHERHESKG-UHFFFAOYSA-N tetrahydrocurcumin Chemical compound C1=C(O)C(OC)=CC(CCC(=O)CC(=O)CCC=2C=C(OC)C(O)=CC=2)=C1 LBTVHXHERHESKG-UHFFFAOYSA-N 0.000 claims abstract description 62
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 51
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 38
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 38
- 239000011718 vitamin C Substances 0.000 claims abstract description 38
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 35
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 35
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 35
- 229940016667 resveratrol Drugs 0.000 claims abstract description 35
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims abstract description 29
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims abstract description 28
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims abstract description 27
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims abstract description 27
- 229940114124 ferulic acid Drugs 0.000 claims abstract description 27
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000001785 ferulic acid Nutrition 0.000 claims abstract description 27
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims abstract description 27
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229940099563 lactobionic acid Drugs 0.000 claims abstract description 26
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims abstract description 25
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims abstract description 23
- 229960003232 troxerutin Drugs 0.000 claims abstract description 23
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 19
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims abstract description 19
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 19
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 19
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 230000000694 effects Effects 0.000 abstract description 23
- 239000003795 chemical substances by application Substances 0.000 abstract description 13
- 230000003647 oxidation Effects 0.000 abstract description 8
- 238000007254 oxidation reaction Methods 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 7
- 230000002378 acidificating effect Effects 0.000 abstract description 6
- 230000002035 prolonged effect Effects 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 74
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000003963 antioxidant agent Substances 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 230000002421 anti-septic effect Effects 0.000 description 4
- 229940051250 hexylene glycol Drugs 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- -1 flavonoid compound Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, in particular to a novel skin care water agent for stabilizing vitamin c, which comprises the following raw materials in parts by weight: 15 parts of ethoxy diglycol, 15 parts of dipropylene glycol, 15 parts of vitamin c, 3 parts of resveratrol, 1 part of tetrahydrocurcumin, 1 part of ferulic acid, 1 part of troxerutin, 2 parts of lactobionic acid, 0.5 part of ectoine, 2 parts of hexanediol, 0.4 part of potassium sorbate and 44.1 parts of water. The troxerutin, the resveratrol and the tetrahydrocurcumin with strong oxidation resistance have a synergistic oxidation resistance effect on the vitamin C in the skin care water aqua, so that the stability of the vitamin C in the skin care water aqua is improved, the risk of oxidation of the vitamin C in the skin care water aqua in the using and storing processes is reduced, and the quality guarantee period of the vitamin C is further prolonged. Meanwhile, according to the property of better stability of vitamin C under acidic conditions, ferulic acid and lactobionic acid are introduced to provide a weakly acidic environment, so that the stability of the vitamin C is further improved.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a novel skin care lotion for stabilizing vitamin c.
Background
Vitamin C, also called ascorbic acid, has anti-wrinkle, skin whitening effects, has many advantages when used for topical applications, and thus has been widely used in cosmetic formulations, but is easily oxidized due to its structural instability, and is already oxidized seriously from the time of production to the time of arrival at the hands of the customer, and on the other hand, if penetration-promoting and synergistic antioxidant protection are not well done, even if fresh vitamin C is used on the skin, its efficacy is good although its market application is limited because the skin is temporarily yellow due to its heat and sufficient exposure to the air, and poor absorption causes the vitamin C to be oxidized and yellow before it is absorbed by the skin, i.e., the skin care effect of the ingredients themselves is not achieved, and the skin is temporarily yellow and the experience of use is poor.
Summary of the invention
In order to overcome the defects of the prior art, the invention provides a novel skin care lotion capable of stabilizing vitamin c.
The invention adopts the following technical scheme:
a novel skin care lotion for stabilizing vitamin c comprises the following raw materials in parts by weight: 5-20 parts of ethoxy diglycol; 5-20 parts of dipropylene glycol; 5-20 parts of vitamin c; 0.5-5 parts of resveratrol; 0.1-3 parts of tetrahydrocurcumin; 0.1-2 parts of ferulic acid; 0.5-3 parts of troxerutin; 0.5-3 parts of lactobionic acid; 0.1-2 parts of ectoin; 0.5-4 parts of hexanediol; 0.1-0.8 part of potassium sorbate; the water is increased to 100 parts.
As a further improvement, 15 parts of ethoxydiglycol; 15 parts of dipropylene glycol; 15 parts of vitamin c; 3 parts of resveratrol; 1 part of tetrahydrocurcumin; 1 part of ferulic acid; 1 part of troxerutin; 2 parts of lactobionic acid; 0.5 part of ectoin; 2 parts of hexanediol; 0.4 part of potassium sorbate; 44.1 parts of water.
As a further improvement, 20 parts of ethoxy diglycol; 20 parts of dipropylene glycol; 5 parts of vitamin C; 0.5 part of resveratrol; 0.1 part of tetrahydrocurcumin; 2 parts of ferulic acid; 3 parts of troxerutin; 3 parts of lactobionic acid; 2 parts of ectoin; 4 parts of hexanediol; 0.8 part of potassium sorbate; 39.6 parts of water.
As a further improvement, 15 parts of ethoxydiglycol; 15 parts of dipropylene glycol; 20 parts of vitamin c; 5 parts of resveratrol; 3 parts of tetrahydrocurcumin; 0.1 part of ferulic acid; 0.5 part of troxerutin; 0.5 part of lactobionic acid; 0.1 part of ectoin; 0.5 part of hexanediol; 0.1 part of potassium sorbate; 40.2 parts of water.
From the above description of the preparation of the present invention, it can be seen that the present invention has the following advantages over the prior art: the skin care lotion comprises ethoxy diglycol, dipropylene glycol, vitamin c, resveratrol, tetrahydrocurcumin, ferulic acid, troxerutin, lactobionic acid, ectoin, hexanediol, potassium sorbate and water. The skin care aqua containing vitamin c, which is prepared by mixing the troxerutin, the resveratrol, the tetrahydrocurcumin, the ferulic acid and the lactobionic acid with strong oxidation resistance, can ensure that the vitamin c can stably keep activity for a long time in an aqueous solution. Troxerutin, resveratrol, tetrahydrocurcumin and ferulic acid are strong antioxidant components, and can play a role in synergistic antioxidation when existing in an aqueous solution together with vitamin C, and simultaneously have better stability under an acidic condition according to the property of the vitamin C, so that ferulic acid and lactobionic acid are introduced to provide a weakly acidic environment, the stability of vitamin C is further improved, the risk of oxidation of the vitamin C in the skin care water agent in the using and storing processes is reduced, the quality guarantee period of the vitamin C is further prolonged, and the activity and the using effect of the vitamin C and the skin care water agent are ensured.
Detailed Description
A novel skin care lotion for stabilizing vitamin c comprises the following raw materials in parts by weight: 5-20 parts of ethoxy diglycol; 5-20 parts of dipropylene glycol; 5-20 parts of vitamin c; 0.5-5 parts of resveratrol; 0.1-3 parts of tetrahydrocurcumin; 0.1-2 parts of ferulic acid; 0.5-3 parts of troxerutin; 0.5-3 parts of lactobionic acid; 0.1-2 parts of ectoin; 0.5-4 parts of hexanediol; 0.1-0.8 part of potassium sorbate; the water is increased to 100 parts, wherein the hexanediol is 1, 2-hexanediol and has certain antibacterial and antiseptic effects; the vitamin C can resist oxidation, remove free radicals, resist ageing and lightening wrinkles, inhibit melanin and whiten skin, and is very soluble in water; resveratrol, tetrahydrocurcumin, ferulic acid and lactobionic acid have good antioxidation, and have the skin care effects of repairing, resisting aging, fading spots, whitening and the like after being absorbed by a human body, and resveratrol and tetrahydrocurcumin are difficult to dissolve in water; the ethoxy diglycol and the dipropylene glycol are excellent solvents and can disperse various insoluble substances, wherein the ethoxy diglycol has a certain permeation promoting effect, can promote the transdermal absorption rate of various components and simultaneously has a moisturizing effect; troxerutin is a flavonoid compound, is antioxidant, is usually accompanied by vitamin c in the nature, has the effect of stabilizing the vitamin c, and also has the effects of resisting edema and resisting coagulation; the potassium sorbate is an efficient and safe preservative, has extremely low toxicity, is high in safety and has the best preservative effect in an acidic environment. The ectoin can effectively improve the immune protection capability of skin cells, increase the cell repair capability, effectively resist the invasion of microorganisms and allergens by the skin, and improve the integral photolysis resistance of the skin care aqua.
During operation, water, ethoxydiglycol, dipropylene glycol, vitamin C, resveratrol, tetrahydrocurcumin, ferulic acid, troxerutin, lactobionic acid, ectoin, hexanediol and potassium sorbate are stirred and mixed at normal temperature, wherein an antioxidant environment formed by troxerutin, resveratrol, tetrahydrocurcumin, ferulic acid and lactobionic acid is utilized, so that the stability of the vitamin C in an aqueous solution is improved, the risk of oxidation of the vitamin C in the skin care water aqua in the use and storage processes is reduced, the quality guarantee period of the vitamin C is further prolonged, and the use effect of the vitamin C is ensured. And the troxerutin, the resveratrol, the tetrahydrocurcumin, the ferulic acid and the lactobionic acid have the skin care effects of repairing, resisting aging, lightening spots, whitening and the like after being absorbed by a human body, and the skin care effect of the skin care lotion can be improved.
Meanwhile, lactobionic acid and ferulic acid can provide an environment with a low ph value, vitamin c can be more stable in the environment with the low ph value, the stability of the vitamin c in the skin care lotion is further improved, the low ph value is favorable for the vitamin c to permeate into the skin, the skin penetration rate of the skin care lotion is improved, the vitamin c is promoted to be absorbed by the skin, and the skin care effect of the skin care lotion is improved. The environment with low pH value can enable the potassium sorbate to fully exert the antiseptic effect, the potassium sorbate and the hexanediol are matched for use, the high-efficiency safe antiseptic effect of the skin care water agent can be realized, other substances are not needed to be added to increase the antiseptic and antibacterial effects, space is reserved for other active ingredients, the proportion of the active ingredients in the skin care water agent is increased, and the skin care effect of the skin care water agent is further enhanced.
The three polyols, namely ethoxy diglycol, dipropylene glycol and hexanediol, can be used for uniformly dispersing insoluble resveratrol and tetrahydrocurcumin in the skin care water agent, and the three polyols and water can form sol in a specific proportion range, so that the resveratrol and the tetrahydrocurcumin can stably disperse in the water agent to form colloid (the water agent is detected and identified by using the Tyndall effect, is clear and transparent, but can generate a light path under the irradiation of light beams, and is caused by the scattering of the sol on light rays. Because the two components are not dissolved in water, most skin care products on the market basically adopt an emulsification dispersion mode when preparing the skin care products, the dispersion particle size of the resveratrol and the tetrahydrocurcumin is more than 100 nanometers in the emulsification dispersion mode, the dispersion particle size is large, the skin utilization rate is relatively reduced, in the formula, a novel sol-type dispersion is adopted, the specific proportion of the polyhydric alcohol and the water is utilized to ensure that the polyhydric alcohol and the water are uniformly distributed in the water to form colloid, the diameter of the colloidal particles is 1-100 nanometers, compared with the traditional particle size of more than 100 nanometers of emulsification and dispersion, the formula can ensure that the active ingredients can be better absorbed, simultaneously, the active ingredients can better contact with vitamin c dispersed in water in a larger area, thereby providing a better environment for synergistically resisting oxygen for the vitamin C and better maintaining the stability of the vitamin C. The colloidal particles in the colloid can not only effectively protect the stability of the vitamin c in the skin care aqua, but also have a certain self-protection effect on self body molecules in the micelle due to the fact that the self molecules exist in the micelle form, so that the stability of the vitamin c in the skin care aqua is protected, and the self activities of resveratrol and tetrahydrocurcumin can be protected to a greater extent, so that the resveratrol and the tetrahydrocurcumin can enter the skin to play a role in the maximum activity before the resveratrol and the tetrahydrocurcumin are absorbed by the skin.
In addition, the safety scores of the ethoxy diglycol, the dipropylene glycol and the hexanediol are all 1 or 2, the skin care lotion can be authenticated and inquired through an EWG (EWG is short for Environmental Working Group in the United states), the use safety degree is extremely high, the acne resistance is avoided, a certain permeation promoting effect is realized, the transdermal absorption rate of various components can be promoted, the skin care lotion has a moisturizing effect, and the use of the ethoxy diglycol, the dipropylene glycol and the hexanediol meets the requirements of good skin feel, high safety degree and large amount of dissolved active substances, so that the skin care lotion is more moisturizing, stable, safe and efficient in skin care.
The addition of ectoin can improve the whole anti-ultraviolet capability of the skin care water agent, prevent the skin care water agent from being damaged more before being absorbed by skin, ensure that the skin care water agent does not cause great loss of active ingredients even in the daytime, ensure the skin care effect of the skin care water agent, and the ectoin can effectively improve the immune protection capability of skin cells after being absorbed by human body, increase the cell repair capability, ensure that the skin can effectively resist the invasion of microorganisms and allergens, reduce the sensitivity of the skin and reduce the occurrence of allergy.
Experimental detection
(1) Under the condition of the same content of vitamin C, the components for stabilizing the vitamin C in the formula are continuously increased, and the action effect of the components for stabilizing the vitamin C is compared.
The raw material formula of the control group 1 is as follows: 15 parts of vitamin c and 85 parts of water.
Example group 1 raw material recipe: 10 parts of ethoxy diglycol, 10 parts of dipropylene glycol, 15 parts of vitamin c, 1 part of resveratrol, 10 parts of hexanediol and 54 parts of water.
Example group 2 raw material recipe: 15 parts of ethoxy diglycol, 15 parts of dipropylene glycol, 15 parts of vitamin c, 3 parts of resveratrol, 2 parts of hexanediol and 52 parts of water.
Example group 3 stock formulation: 15 parts of ethoxy diglycol, 15 parts of dipropylene glycol, 15 parts of vitamin c, 3 parts of resveratrol, 1 part of ferulic acid, 2 parts of lactobionic acid, 2 parts of hexanediol and 47 parts of water.
Example group 4 stock formulation: 15 parts of ethoxy diglycol, 15 parts of dipropylene glycol, 15 parts of vitamin c, 3 parts of resveratrol, 1 part of tetrahydrocurcumin, 1 part of ferulic acid, 2 parts of lactobionic acid, 2 parts of hexanediol and 46 parts of water.
Example group 5 raw material recipe: 15 parts of ethoxy diglycol, 15 parts of dipropylene glycol, 15 parts of vitamin c, 3 parts of resveratrol, 1 part of tetrahydrocurcumin, 1 part of ferulic acid, 1 part of troxerutin, 2 parts of lactobionic acid, 2 parts of hexanediol and 45 parts of water.
Example group 6 stock formulation: 15 parts of ethoxy diglycol, 15 parts of dipropylene glycol, 15 parts of vitamin c, 3 parts of resveratrol, 1 part of tetrahydrocurcumin, 1 part of ferulic acid, 1 part of troxerutin, 2 parts of lactobionic acid, 0.5 part of ectoin, 2 parts of hexanediol, 0.4 part of potassium sorbate and 44.1 parts of water.
The experimental process comprises the following steps: 18 parts of the skin care lotion prepared in each of examples 1 to 6 and control 1, 126 parts in total, and 126 parts of the skin care lotion prepared in each of examples 1 to 6 and control 1 were stored in a 37 ℃ thermostat (simulating a higher daily use temperature) in a dark place, 3 parts of each example were taken at 1,2, 3, 4, 5, and 6 weeks, respectively, and the percentage of the remaining amount of vitamin c in the samples was measured, and the average value of three samples was taken for each example.
The record of the experimental results is shown in Table 1
TABLE 1
As can be seen from the comparison of the data of the control group 1 and the example group 1 in table 1, the introduction of resveratrol greatly increases the stability of vitamin c in aqueous solution, and as can be seen from the comparison of the data of the example groups 1 and 2, the stability of vitamin c is further improved as the resveratrol increases. From the comparison of the data of example groups 2 and 3, it is evident that the addition of ferulic acid and lactobionic acid provides an acidic environment, indeed contributing to the improvement of the stability of vitamin c in aqueous solution, with unchanged antioxidant components. As can be seen from the comparison of the data of example groups 3, 4 and 5, after more antioxidant components of tetrahydrocurcumin and troxerutin are introduced, the residual quantity of vitamin c after six weeks is still more than 95%, which is far higher than the situation that the loss of the control group 1 is nearly half. While example 6 is ectoin with added preservative system potassium sorbate and uv light resistance, it can be seen from a comparison of the data from examples 6 and 5 that their addition does not substantially change the stability of vitamin c in the formulation.
(2) After the stabilizing effect of each component on the stabilized vitamin C is measured, the effect of different contents of the same component on the stabilized vitamin C is further tested.
Example group 7 stock formulation: 20 parts of ethoxy diglycol, 20 parts of dipropylene glycol, 5 parts of vitamin C, 0.5 part of resveratrol, 0.1 part of tetrahydrocurcumin, 2 parts of ferulic acid, 3 parts of troxerutin, 3 parts of lactobionic acid, 2 parts of ectoin, 4 parts of hexanediol, 0.8 part of potassium sorbate and 39.6 parts of water.
Example group 8 stock formulation: 15 parts of ethoxy diglycol, 15 parts of dipropylene glycol, 20 parts of vitamin c, 5 parts of resveratrol, 3 parts of tetrahydrocurcumin, 0.1 part of ferulic acid, 0.5 part of troxerutin, 0.5 part of lactobionic acid, 0.1 part of ectoin, 0.5 part of hexanediol, 0.1 part of potassium sorbate and 40.2 parts of water.
The experimental process comprises the following steps: the skin care lotions prepared in the above example groups 6 to 8 were taken 18 parts each, 54 parts each, and 54 samples were stored in a 37 ℃ thermostat and protected from light, 3 parts each at 1,2, 3, 4, 5, and 6 weeks, respectively, and the stabilized vitamin c content in the samples was measured, and the average of three samples was taken for each sample.
The record of the experimental results is shown in Table 2
TABLE 2
The data in table 2 show that the skin care water aqua with the added samples of different amounts of components has the residual proportion of vitamin C in the example group 6 higher than that of vitamin C in the example groups 7 and 8, and the residual proportion of vitamin C in the example group 6 is the highest, so that the formula can improve the stability of vitamin C in the prepared skin care water aqua, and the component proportioning effect in the example group 6 is the best, so that the risk of oxidation of vitamin C in the skin care water aqua in the use and storage process can be greatly reduced, the shelf life of the vitamin C is prolonged, and the use effect of the vitamin C is ensured.
(3) The effect of ethoxydiglycol, dipropylene glycol and hexylene glycol on the moisturizing performance of skin moisturizers was tested.
Control group 2: control 2 was substantially the same as the example 6 stock formulation except that control 2 did not contain ethoxydiglycol, dipropylene glycol, and hexylene glycol.
The experimental process comprises the following steps: the skin care lotions prepared in the above example groups 6 to 8 and the control group 2 were respectively 20 parts, and total 80 parts. Selecting 80 test persons from ordinary persons of 25-35 ages at random, dividing into 5 groups, each group having 20 persons, wiping example groups 6-8 and control group 2 on the skin of the same part, wiping for 5 minutes, wiping off residual samples on the skin, detecting the skin moisture content of each group of persons by using a skin moisture tester (German CK brand, and model is Corneometer CM825 MDD), and taking the average value after removing one highest value and one lowest value from each group of detection data.
The record of the experimental results is shown in Table 3
TABLE 3
The data in table 3 show that the skin care lotion prepared by wiping the skin care lotion samples containing different amounts of ethoxydiglycol, dipropylene glycol and hexylene glycol for five minutes had a higher water content in the skins of the patients of examples 6-8 than in the skin of the patient of control 2, and the highest water content in the skin of example 6 indicates that the skin care lotion prepared by wiping the samples containing different amounts of ethoxydiglycol, dipropylene glycol and hexylene glycol was effective in moisturizing the skin care lotion compared with an aqueous solution.
The above description is only an embodiment of the present invention, but the design concept of the present invention is not limited thereto, and any insubstantial modifications made by using the design concept should fall within the scope of infringing the present invention.
Claims (4)
1. The novel skin care lotion for stabilizing vitamin c is characterized by comprising the following raw materials in parts by weight: 5-20 parts of ethoxy diglycol; 5-20 parts of dipropylene glycol; 5-20 parts of vitamin c; 0.5-5 parts of resveratrol; 0.1-3 parts of tetrahydrocurcumin; 0.1-2 parts of ferulic acid; 0.5-3 parts of troxerutin; 0.5-3 parts of lactobionic acid; 0.1-2 parts of ectoin; 0.5-4 parts of hexanediol; 0.1-0.8 part of potassium sorbate; the water is increased to 100 parts.
2. The novel vitamin c stabilizing skin care lotion according to claim 1, wherein: 15 parts of ethoxy diglycol; 15 parts of dipropylene glycol; 15 parts of vitamin c; 3 parts of resveratrol; 1 part of tetrahydrocurcumin; 1 part of ferulic acid; 1 part of troxerutin; 2 parts of lactobionic acid; 0.5 part of ectoin; 2 parts of hexanediol; 0.4 part of potassium sorbate; 44.1 parts of water.
3. The novel vitamin c stabilizing skin care lotion according to claim 1, wherein: 20 parts of ethoxy diglycol; 20 parts of dipropylene glycol; 5 parts of vitamin C; 0.5 part of resveratrol; 0.1 part of tetrahydrocurcumin; 2 parts of ferulic acid; 3 parts of troxerutin; 3 parts of lactobionic acid; 2 parts of ectoin; 4 parts of hexanediol; 0.8 part of potassium sorbate; 39.6 parts of water.
4. The novel vitamin c stabilizing skin care lotion according to claim 1, wherein: 15 parts of ethoxy diglycol; 15 parts of dipropylene glycol; 20 parts of vitamin c; 5 parts of resveratrol; 3 parts of tetrahydrocurcumin; 0.1 part of ferulic acid; 0.5 part of troxerutin; 0.5 part of lactobionic acid; 0.1 part of ectoin; 0.5 part of hexanediol; 0.1 part of potassium sorbate; 40.2 parts of water.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115813801A (en) * | 2022-12-27 | 2023-03-21 | 华熙生物科技股份有限公司 | Ascorbic acid transdermal absorption composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875034A (en) * | 2017-10-11 | 2018-04-06 | 广东药科大学 | A kind of compound anti-oxidation is from micro emulsion and its preparation method and application |
| CN109820739A (en) * | 2018-11-27 | 2019-05-31 | 广州瑞誉化工科技有限公司 | A kind of skin composition and its preparation method and application of Plantain skin lightening |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875034A (en) * | 2017-10-11 | 2018-04-06 | 广东药科大学 | A kind of compound anti-oxidation is from micro emulsion and its preparation method and application |
| CN109820739A (en) * | 2018-11-27 | 2019-05-31 | 广州瑞誉化工科技有限公司 | A kind of skin composition and its preparation method and application of Plantain skin lightening |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115813801A (en) * | 2022-12-27 | 2023-03-21 | 华熙生物科技股份有限公司 | Ascorbic acid transdermal absorption composition and application thereof |
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