CN113662881A - Composition for repairing sensitive skin, preparation method and application thereof - Google Patents
Composition for repairing sensitive skin, preparation method and application thereof Download PDFInfo
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- CN113662881A CN113662881A CN202111158185.5A CN202111158185A CN113662881A CN 113662881 A CN113662881 A CN 113662881A CN 202111158185 A CN202111158185 A CN 202111158185A CN 113662881 A CN113662881 A CN 113662881A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention provides a composition for repairing sensitive skin, which comprises the following raw materials in parts by weight: 1-4 parts by weight of ultramicro sodium hyaluronate; 0.5-2 parts by weight of acetylated sodium hyaluronate; 0.5-2 parts by weight of ectoin; 0.25 to 1 part by weight of madecassoside. The invention selects four components of ultramicro sodium hyaluronate, acetylated sodium hyaluronate, ectoin and madecassoside for compatibility, and combines a specific weight ratio, thereby promoting fibroblast proliferation and increase of collagen expression, promoting epidermal cell proliferation, repairing damaged epidermal cells, and enhancing the barrier function of skin, thereby realizing the effect of skin repair. Meanwhile, the skin inflammation relieving ointment can relieve the skin injury caused by inflammation, reduce the generation of proinflammatory mediators IL-1 and MMPs, reduce the inflammatory reaction of the skin and realize the effects of resisting inflammation and relieving. The composition for repairing sensitive skin has the advantages of simple components, specific effect, high biocompatibility and high safety.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition for repairing sensitive skin, and a preparation method and application thereof.
Background
With the development of society and the improvement of living standard of people, the skin care problem is more and more paid attention by consumers. The need for skin care has shifted from previous prevention and delay to current restorative aspects. Particularly, the modern living rhythm is accelerated, the working pressure is increased, and the night is increased, so that the skin state of a consumer is poorer and poorer, and the trend of changing to sensitive skin is accompanied. The sensitive skin means that the skin generates various reactions which are not tolerant to the skin under the external stimulation, and various problems such as redness, peeling, tightness and the like occur, and the sensitive skin is essentially characterized in that the skin cuticle is thinned to cause the skin moistening degree to be insufficient, and finally, the barrier function of the skin is too weak to resist the external stimulation.
Sensitive skin, due to its special intolerance characteristics, not only responds significantly to external stimuli, but also makes healing more difficult. From the composition, most of the skin care products for repairing sensitive skin in the market are composed of various plant extracts. However, different natural plant extracts may bring about synergistic and antagonistic effects during the compounding process. Adding multiple plant extracts without hasty while the additive effects of efficacy and effects have not been analyzed and verified is not necessarily a sensible option. In addition, the addition of various plant extracts adds extra burden to sensitive skin and has opposite effects on skin repair.
Therefore, the development of a composition which has simple components and has the effects of skin repair, inflammation resistance and soothing is urgent.
Disclosure of Invention
In view of the above, the invention provides a composition for repairing sensitive skin, and the composition for repairing sensitive skin provided by the invention has extremely high affinity to sensitive skin and can repair sensitive skin.
Sensitive skin generally has the following skin characteristics: the skin looks thin and is easy to be allergic, and the red blood streak on the face is obvious. The skin is easily reddened, and generally, the skin is easily reddened and heated due to temperature change, supercooling or overheating. Environmental factors (contact sensitive muscles, redness sensitive muscles, pressure sensitive muscles), seasonal changes and facial cosmetic irritations are common to genetic factors, but more so because of the use of hormonal cosmetics, which lead to sensitive skin and may be accompanied by systemic skin sensitivity.
The invention provides a composition for repairing sensitive skin, which comprises the following raw materials in parts by weight:
the weight portions are equivalent to weight percent when the total amount is 100.
The composition for repairing sensitive skin provided by the invention comprises 1-4 parts by weight of ultramicro sodium hyaluronate; specifically, the amount of the organic solvent may include 1 part by weight, 2 parts by weight, 3 parts by weight, 4 parts by weight, or a value between any two of the above.
The ultramicro sodium hyaluronate is commercial micro eight hundred hyaluronic acid of the company. Hyaluronic Acid (HA), also known as hyaluronic acid, HAs a molecular formula of (C)14H21NO11)nIs a disaccharide glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid has high viscoelasticity, plasticity, super-strong water retention property, permeability and good biological absorbability, and is widely applied to the fields of cosmetics, medicine, food and the like. The biological activity and use effect of HA are directly related to their relative molecular weights, so that different efficacies and effects are exhibited according to the difference in their molecular weights. For example, high molecular weights (Mr > 2X 10)6) The HA (HMWHA) of (A) has better viscoelasticity, moisture retention, inflammatory reaction inhibition and the like; and the molecular weight is 1-2X 106The HA HAs good moisture retention, lubrication and drug slow release effects; low Molecular Weight HA (LMWHA)Has antitumor, wound healing, bone and blood vessel generation promoting, and immunity regulating effects.
The ultramicro sodium hyaluronate is hydrolyzed sodium hyaluronate with ultrahigh biological activity, the molecular weight of which is less than 5000, and the hydrolyzed sodium hyaluronate is obtained by adopting a professional enzyme digestion process and a spray drying/freeze drying technology.
The molecular weight of the ultramicro sodium hyaluronate is below 5000.
The composition for repairing sensitive skin provided by the invention comprises 0.5-2 parts by weight of acetylated sodium hyaluronate. Specifically, it may include 0.5 parts by weight, 1 part by weight, 2 parts by weight, or a point value between any two of the above.
The acetylated sodium hyaluronate is obtained by acetylation reaction of natural moisturizing factor sodium Hyaluronate (HA), and introduction of acetyl brings lipophilicity to HA, so that affinity and adsorbability of HA to skin are enhanced.
The composition for repairing sensitive skin provided by the invention comprises 0.5-2 parts by weight of ectoin as a raw material; specifically, it may include 0.5 parts by weight, 1 part by weight, 2 parts by weight, or a point value between any two of the above.
The invention provides a composition for repairing sensitive skin, which comprises 0.25-1 part by weight of madecassoside; specifically, it may be 0.25 parts by weight, 0.5 parts by weight, 1 part by weight, or a point value between any two of the above.
Madecassoside (MC) is the main active ingredient of triterpenoid saponin in centella asiatica of the family umbelliferae.
In some embodiments, the composition for repairing sensitive skin provided by the invention comprises the following raw materials in parts by weight:
in some embodiments, the composition for repairing sensitive skin provided by the invention comprises the following raw materials in parts by weight:
in some embodiments, the composition for repairing sensitive skin provided by the invention comprises the following raw materials in parts by weight:
in some embodiments, the composition for repairing sensitive skin provided by the invention comprises the following raw materials in parts by weight:
the invention selects four components of ultramicro sodium hyaluronate, acetylated sodium hyaluronate, ectoin and madecassoside for compatibility, and combines a specific weight ratio, thereby promoting fibroblast proliferation and increase of collagen expression, promoting epidermal cell proliferation, repairing damaged epidermal cells, and enhancing the barrier function of skin, thereby realizing the effect of skin repair. Meanwhile, the skin inflammation relieving ointment can relieve the skin injury caused by inflammation, reduce the generation of proinflammatory mediators IL-1 and MMPs, and reduce the inflammatory reaction of the skin, thereby realizing the effects of resisting inflammation and relieving. The whole composition only contains four functional components, and the functional components are all high molecular polysaccharide and plant extract with extremely high biocompatibility, and have extremely high affinity for sensitive skin. The composition for repairing sensitive skin integrates simple components, special effect, prevention and treatment combination, high biocompatibility and high safety, and has certain unique advantages and wide application prospect.
The invention provides application of any one of the compositions in preparation of a product for repairing sensitive skin.
The method for repairing sensitive skin comprises the steps of increasing the moisture content of the horny layer of the skin, reducing the water loss of the skin, increasing the elasticity of the skin, improving red blood streak or reducing lactic acid stabbing pain.
The product is not limited, and can be cosmetics, and the dosage form of the product can be water, milk, cream and the like.
The invention provides a product for repairing sensitive skin, which comprises the composition in any one of the technical schemes.
In the product provided by the invention, the composition accounts for 2-9% of the product by weight.
The product provided by the invention is preferably a cosmetic, and the cosmetic is a skin cosmetic.
In a part of preferred embodiments of the invention, the raw materials comprise the following components in percentage by mass:
in a part of preferred embodiments of the invention, the raw materials comprise the following components in percentage by mass:
in a part of preferred embodiments of the invention, the raw materials comprise the following components in percentage by mass:
in a part of preferred embodiments of the invention, the raw materials comprise the following components in percentage by mass:
the invention provides a preparation method of a product for repairing sensitive skin, which comprises the following steps:
mixing ultramicro sodium hyaluronate, acetylated sodium hyaluronate, ectoin, madecassoside and water, and stirring.
The present invention is not limited to the specific mixing and stirring manner, and those skilled in the art can easily understand it.
The invention relates to a method for repairing skin, which comprises the following steps: applying the composition of any of the above claims to the skin.
The application may be in particular coating.
Compared with the traditional repairing composition, the skin care composition provided by the invention focuses on skin repair, and meanwhile, the effects of the skin care composition are extended to the fields of water replenishing, moisture preserving, anti-aging, wrinkle removing and the like. While multiple effects impart more functionality to a composition to some extent, diversification of effects is often accompanied by a reduction in the effect of the effects or a complication of the composition. Either the decline in efficacy or the complication of the composition is not conducive to the repair of sensitive skin, and the complicated efficacy composition can cause additional skin burden. The method focuses on the problem of repairing the sensitive skin, starts from the root of the skin problem, and solves the problem of repairing the sensitive skin in multiple dimensions. The composition has more specific efficacy and obviously improves the effect of repairing skin.
The traditional repairing composition achieves the purpose of skin repair mainly by promoting the proliferation of skin cells. However, such compositions only address the existing skin repair issues and do not address the issues of skin inflammation and soothing. The invention combines skin repair and anti-inflammatory relief into a whole and cooperates together, thereby realizing the comprehensive repair of the skin. The repair of the sensitive skin can be effectively realized, the skin inflammation can be reduced, and the problem of the repair of the sensitive skin is fundamentally solved.
The functional composition consists of ultramicro hyaluronic acid, acetylated hyaluronic acid, ectoin and madecassoside, the three polysaccharides have high biocompatibility, and the madecassoside is the main component in the plant extract, so that the composition has high biocompatibility and safety and cannot cause the problem of stimulation to sensitive skin.
Drawings
FIG. 1 is a graph showing the rate of increase in the moisture content of stratum corneum of skin according to examples of the present invention and comparative examples;
FIG. 2 is a graph showing the change in rate of water dispersion loss of skin according to examples of the present invention and comparative examples;
FIG. 3 is a graph showing the change in the skin elasticity improvement rate of examples of the present invention and comparative examples;
FIG. 4 is a graph showing the improvement rate of red blood cells in the skin of the examples and comparative examples of the present invention;
FIG. 5 is a graph showing the change in the lactic acid stinging improvement rate of examples of the present invention and comparative examples.
Detailed Description
The invention provides a composition for repairing sensitive skin, a preparation method and application thereof, and a person skilled in the art can realize the composition by properly improving process parameters by referring to the content. It is expressly intended that all such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the scope of the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The raw materials adopted by the invention are all common products sold in the market and can be purchased in the market.
In order to further illustrate the present invention, the following detailed description will be made of a composition for repairing sensitive skin, a preparation method and applications thereof, which are provided by the present invention, in combination with examples.
Examples 1 to 5
The formula is shown in the table 1:
TABLE 1
The preparation method comprises the following steps:
1. compositions were prepared according to the formulations of examples 1 to 3
2. Accurately weighing the four component raw materials, mixing the four component raw materials according to corresponding proportions, and stirring the mixture to obtain a uniform and transparent aqueous solution.
Comparative examples 1 to 5
The formula is shown in table 2:
TABLE 2
The preparation method comprises the following steps:
1. the composition is prepared according to the formula of comparative examples 1-5
2. Accurately weighing the four component raw materials, mixing the four component raw materials according to corresponding proportions, and stirring the mixture to obtain a uniform and transparent aqueous solution.
Efficacy evaluation
1 Water content of stratum corneum
1) Principle of testing
The invention adopts CK German skin moisture tester CM825 to test the moisture content of the stratum corneum. The water content of the horny layer not only reflects the physiological function of the horny layer of human skin, but also represents the physiological function of the whole skin and even the whole body on the skin. The increase and decrease of the water content of the horny layer are closely related to the damage and repair degree of the skin. When the skin is damaged to a high degree, the moisture content of the stratum corneum of the skin is reduced, and when the damaged skin is repaired, the moisture content of the stratum corneum of the skin is increased. Measuring the water content of the stratum corneum is of great significance to understanding the physiological functions of the body, particularly the repair state of the skin. The present invention is used to measure the efficacy of the efficacy composition in repairing an organ.
2) Test method
-a test environment: the testing environment temperature is 22 +/-1 ℃, the humidity is 50 +/-5%, and real-time dynamic detection is carried out;
-test volunteers: age between 16-60 years (excluding pregnant or lactating women); patients without severe systemic disease, immunodeficiency or autoimmune disease; those who have not had a history of severe allergy to skin care cosmetics in the past; hormone drugs and immunosuppressants have not been used in the last month; those who did not participate in other clinical trials; the tested drugs are used according to the regulations and the data is complete; all volunteers should fill out informed consent before testing.
-a testing step:
preparation before testing: any product (cosmetic or external medicine) cannot be used for 2-3 days before the tested part. Before the test, the skin moisture tester CM825 evaluation was performed by drawing a sample application area on each cheek side of the tester.
-a test procedure: the skin stratum corneum water content of the area demarcated by the cheek of the subject was measured as the original value after the subject was rested in a constant temperature and humidity room for 30 minutes. Then, the same amount of experimental samples are respectively used in the test areas of the testees, the same thickness and time are coated, and the moisture content of the stratum corneum of the skin is respectively measured aiming at the test areas after the skin is washed clean and dried by air. The test of the same volunteer was performed by the same measurement staff.
3) Test results
The calculation formula of the water content increase rate of the horny layer is as follows: c% ((C))2-C1)/C1*100％
Note: c is the moisture content increase rate,%;
C2skin moisture content for continued use of the sample after 28 days;
C1the original value of the skin moisture content before using the sample;
the data are collated in Table 3 below:
TABLE 3
FIG. 1 shows a graph of the rate of change of the moisture content of the stratum corneum of the skin, and FIG. 1 shows a graph of the rate of change of the moisture content of the stratum corneum of the skin according to the examples and comparative examples of the present invention; it can be seen from fig. 1 and table 3 that the composition for repairing sensitive skin provided by the present invention increases the moisture content of the stratum corneum of the skin to some extent, and also laterally feeds back the damaged skin to some extent to be repaired. By comparing the increase rate of the moisture content of the stratum corneum between comparative examples 3 and 4 and example 2, it can be seen that the compositions of the present invention have a synergistic effect between the components, and when some of the components are missing, the efficacy of the compositions is significantly reduced.
2. Percutaneous water loss of skin
1) Principle of testing
The present invention uses a Delfin finland skin moisture loss tester VapoMeter to test the transdermal moisture loss. Transdermal moisture loss refers to the transport of moisture through the skin by passive diffusion, the most common use being the assessment of the skin barrier function and the condition of the skin. The invention is used for measuring the skin state and barrier function after using the efficacy composition and feeding back the repairing effect of the composition.
2) Test method
-a test environment: the testing environment temperature is 22 +/-1 ℃, the humidity is 50 +/-5%, and real-time dynamic detection is carried out;
-test volunteers: age between 16-60 years (excluding pregnant or lactating women); patients without severe systemic disease, immunodeficiency or autoimmune disease; those who have not had a history of severe allergy to skin care cosmetics in the past; hormone drugs and immunosuppressants have not been used in the last month; those who did not participate in other clinical trials; the tested drugs are used according to the regulations and the data is complete; all volunteers should fill out informed consent before testing.
-a testing step:
preparation before testing: any product (cosmetic or external medicine) cannot be used for 2-3 days before the tested part. Before testing, the using area of the sample is drawn on one side of the cheek of the tester respectively, and the evaluation of the skin percutaneous water loss test is carried out.
-a test procedure: the subjects rested in a constant temperature and humidity room for 30 minutes, and then the skin water loss in the area demarcated by the cheek was measured as the original value. Then, the same amount of experimental samples are respectively used in the test areas of the testees, the test areas are coated with the same thickness and time, and the test areas are respectively subjected to percutaneous moisture loss measurement after being washed clean and dried in the air. The test of the same volunteer was performed by the same measurement staff.
3) Test results
The long-acting skin percutaneous water loss improvement rate calculation formula: v% ((V))1-V2)/V1*100％
Note: v is the improvement rate of skin percutaneous water loss,%;
V2the amount of water dispersed through the skin after 28 days of continuous use of the sample;
V1the original value of the skin transdermal water dispersion loss before using the sample;
the experimental data are shown in table 4:
TABLE 4
A change of the skin moisture loss through skin is shown in figure 2, and figure 2 is a change chart of the change of the skin moisture loss through water of the embodiment and the comparative example of the invention.
From the results, the composition for repairing sensitive skin provided by the invention improves the percutaneous water loss of the skin to a certain degree, and indicates that the barrier function of the skin is repaired to a certain degree. The composition of the present invention has a synergistic effect between the components by comparing the skin transdermal moisture improvement rates between comparative examples 3 and 4 and example 2, and the efficacy effect of the composition is remarkably reduced when some components are missing.
3. Elasticity of skin
1) Principle of testing
The invention adopts CK Germany skin elasticity tester Cutomer MPA580 to test the skin elasticity. Skin elasticity is the ability of the skin to stretch and recover its original shape, and is generally related to the content of skin collagen, elastin and natural fats. The invention is used for measuring the recovery condition of skin collagen and elastin, the health condition of skin and the like after the functional composition is used, and is used for feeding back the repairing effect of the composition.
2) Test method
-a test environment: the testing environment temperature is 22 +/-1 ℃, the humidity is 50 +/-5%, and real-time dynamic detection is carried out;
-test volunteers: age between 16-60 years (excluding pregnant or lactating women); patients without severe systemic disease, immunodeficiency or autoimmune disease; those who have not had a history of severe allergy to skin care cosmetics in the past; hormone drugs and immunosuppressants have not been used in the last month; those who did not participate in other clinical trials; the tested drugs are used according to the regulations and the data is complete; all volunteers should fill out informed consent before testing.
-a testing step:
preparation before testing: any product (cosmetic or external medicine) cannot be used for 2-3 days before the tested part. Before the test, the areas of application of the samples were drawn on the cheek sides of the subjects, respectively, and skin elasticity was evaluated.
-a test procedure: the skin elasticity of the area demarcated by the cheek of the subject was measured as the original value after the subject was rested in a constant temperature and humidity chamber for 30 minutes. Then, the same amount of test samples were applied to the test areas of the subjects, respectively, with the same thickness and time, and skin elasticity measurements were performed on the test areas, respectively, after rinsing, and air drying. The test of the same volunteer was performed by the same measurement staff.
3) Test results
Skin elasticity improvement rate calculation formula: n% (N)2-N1)/N1*100％
Note: n is the skin elasticity improvement rate,%;
N2skin elasticity for the continued use of the sample after 28 days;
N1the original value of the skin elasticity before using the sample;
the experimental data are as follows in table 5:
TABLE 5
The change of the skin elasticity improvement rate is obtained as shown in fig. 3, and fig. 3 is a graph showing the change of the skin elasticity improvement rate of the examples and comparative examples of the present invention.
The above results demonstrate that the composition for repairing sensitive skin provided by the invention has the effect of improving the skin elasticity, and the repairing effect of the composition of the invention is also laterally confirmed. The synergistic effect between the components of the composition of the present invention is shown by comparing the skin elasticity improvement rate between comparative examples 3 and 4 and example 2, and the efficacy effect of the composition is remarkably reduced when some components are missing.
4. Skin hemoglobin levels
1) Principle of testing
The present invention uses a skin pigment tester, andrera 3D, to test skin hemoglobin levels. The red blood streak is mainly caused by the fact that the position of a capillary vessel is easier to contact and sense the change of the external environment due to the weakness of the stratum corneum of the face, and therefore the phenomenon of the face is caused by the expansion of the capillary vessel. The method is used for measuring the skin heme level after the use of the efficacy composition, and is used for feeding back the effect of the composition on the restoration of the red blood silk.
2) Test method
-a test environment: the testing environment temperature is 22 +/-1 ℃, the humidity is 50 +/-5%, and real-time dynamic detection is carried out;
-test volunteers: age between 16-60 years (excluding pregnant or lactating women); patients without severe systemic disease, immunodeficiency or autoimmune disease; those who have not had a history of severe allergy to skin care cosmetics in the past; hormone drugs and immunosuppressants have not been used in the last month; those who did not participate in other clinical trials; the tested drugs are used according to the regulations and the data is complete; all volunteers should fill out informed consent before testing.
-a testing step:
preparation before testing: any product (cosmetic or external medicine) cannot be used for 2-3 days before the tested part. Before the test, the sample application area was drawn on the cheek side of the test subject, and skin hemoglobin evaluation was performed.
-a test procedure: after the subject was rested in a constant temperature and humidity room for 30 minutes, the skin red blood streak in the area demarcated by the cheek was measured as the original value. Then, the same amount of test samples were applied to the test areas of the subjects, respectively, and the skin hemoglobin measurement was performed on the test areas after rinsing, air drying, and the like. The test of the same volunteer was performed by the same measurement staff.
3) Test results
Long-acting calculation formula: m% ((M))1-M2)/M1*100％
Note: m is improvement rate of red blood streak,%;
M2skin hemoglobin levels 28 days after application of the samples;
M1is the skin hemoglobin level prior to use of the sample;
the experimental data are shown in table 6:
TABLE 6
FIG. 4 is a graph showing the change of the improvement rate of red blood cells in the skin, and FIG. 4 is a graph showing the change of the improvement rate of red blood cells in the skin according to the example of the present invention and the comparative example.
As can be seen from FIG. 4, the composition of the present invention has the effect of repairing red blood cells, and the skin hemoglobin is significantly reduced after the composition of the present invention is applied. By comparing the improvement rate of the red blood cells of the skin between the comparative examples 3 and 4 and the example 2, the composition of the invention has synergistic effect, and when partial components are absent, the efficacy effect of the composition is obviously reduced.
5. Evaluation of lactic acid stinging
1) Principle of testing
It is thought that the development of skin sensitization is a complex process involving the skin barrier-cutaneous nervous system-skin immune cells. Under the combined action of internal and external factors, the barrier function of the skin is damaged, so that the sensory nerve afferent signals are increased, the response of the skin to external stimulation is enhanced, and the skin immune inflammatory response is initiated. The score of lactic acid stabbing pain tests before and after using the product can directly reflect the repairing effect of the product on the skin barrier function. The present invention tests the skin barrier repair efficacy of the composition by assessing lactic acid stinging before and after use of the product.
2) Test method
-a test environment: the testing environment temperature is 22 +/-1 ℃, the humidity is 50 +/-5%, and real-time dynamic detection is carried out;
-test volunteers: age between 16-60 years (excluding pregnant or lactating women); patients without severe systemic disease, immunodeficiency or autoimmune disease; those who have not had a history of severe allergy to skin care cosmetics in the past; hormone drugs and immunosuppressants have not been used in the last month; those who did not participate in other clinical trials; the tested drugs are used according to the regulations and the data is complete; all volunteers should fill out informed consent before testing.
-a testing step:
preparation before testing: any product (cosmetic or external medicine) cannot be used for 2-3 days before the tested part.
-a test procedure: the subject sits statically in a constant temperature and humidity room for 30 minutes, then uses 10% lactic acid water solution and distilled water with equal amount in the left and right nasolabial folds of the subject respectively, and inquires the self skin feeling symptoms of the subject at 0.5, 2 and 5min, and scores according to a quartering method: no prickling sensation is 0 point, slight prickling sensation is 1 point, moderate prickling sensation is 2 points, and severe prickling sensation is 3 points. The test of the same volunteer was performed by the same measurement staff.
3) Test results
The lactic acid stabbing pain improvement rate calculation formula is as follows: r ═ R1-R2)/R1×100％
R: lactic acid sting improvement rate;
R1: pre-sample lactate sting scores;
R2: lactate sting score 28 days after using the sample;
lactic sting score 0.5min +2min +5min sting score;
the experimental data are shown in table 7:
TABLE 7
Fig. 5 is a graph showing the change of the lactic acid stinging improvement rate, and fig. 5 is a graph showing the change of the lactic acid stinging improvement rate of the example of the present invention and the comparative example.
The results show significant differences, which indicate that the composition for repairing sensitive skin provided by the invention has the efficacy of repairing skin barriers. By comparing the improvement rates of comparative examples 3 and 4 with example 2, it can be seen that the efficacy composition of the present invention has a synergistic effect, and the efficacy effect of the composition is remarkably decreased when some components are absent. The lactic acid sting test result shows that the composition has polar irritation, and the skin sensitivity can be obviously reduced and the external irritation can be relieved by using the composition.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The composition for repairing sensitive skin is characterized by comprising the following raw materials in parts by weight:
2. the composition according to claim 1, characterized in that it comprises the following raw materials in parts by weight:
3. the composition as claimed in claim 1, wherein the molecular weight of the sodium hyaluronate is below 5000.
4. Use of a composition according to any one of claims 1 to 3 for the preparation of a product for repairing sensitive skin.
5. The use according to claim 4, wherein the repair of sensitive skin comprises increasing the moisture content of the stratum corneum of the skin, reducing the loss of moisture from the skin, increasing the elasticity of the skin, improving red blood streaks, or reducing lactic prickling.
6. A product for repairing sensitive skin comprising the composition of any one of claims 1 to 3.
7. The product according to claim 7, characterized in that the composition is present in a percentage of between 2% and 9% by weight of the product.
8. The product according to claim 7, characterized by comprising the following raw materials in percentage by mass:
9. a method for preparing a product for restoring sensitive skin according to any one of claims 6 to 8, comprising:
mixing ultramicro sodium hyaluronate, acetylated sodium hyaluronate, ectoin, madecassoside and water, and stirring.
10. A method of repairing skin comprising: applying the composition according to any one of claims 1 to 3 to the skin.
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| CN113662881B (en) | 2023-05-23 |
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