CN106138521A - A kind of cicatrix repairs gel and preparation method thereof - Google Patents

A kind of cicatrix repairs gel and preparation method thereof Download PDF

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Publication number
CN106138521A
CN106138521A CN201610483292.8A CN201610483292A CN106138521A CN 106138521 A CN106138521 A CN 106138521A CN 201610483292 A CN201610483292 A CN 201610483292A CN 106138521 A CN106138521 A CN 106138521A
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cicatrix
gel
preservative
parts
minutes
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施永杰
张烨倩
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Zhengzhou Leiman Pharmaceutical Co Ltd
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Zhengzhou Leiman Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses a kind of cicatrix and repair gel, it is made up of the raw material of following portions by weight: heparin sodium 0.03 ~ 0.05 part, hyaluronic acid 0.04 ~ 0.06 part, Aloe powder 0.04 ~ 0.06 part, Semen Vitis viniferae extract 0.04 ~ 0.06 part, vitamin E 0.05 ~ 0.15 part, Oleum lavandula angustifolia 0.05 ~ 0.15 part, bisabolol 0.12 ~ 0.25 part, nicotiamide 0.35 ~ 0.7 part, carbomer 0.6 ~ 0.8 part, allantoin 0.8 ~ 1.3 part, Herba Centellae extract 0.8 ~ 1.3 part, glycerol 5 ~ 6.8 parts, solubilizing agent 1 ~ 1.4 part, nertralizer 0.2 ~ 0.8 part, 0.05 ~ 0.15 part of essence, preservative 0.25 ~ 0.35 part, 85 ~ 91 parts of water.Preparation process of the present invention is easy, and constant product quality, safe and non-stimulating, skin care, life-time service can repair scarred skin.

Description

A kind of cicatrix repairs gel and preparation method thereof
Technical field
The invention belongs to cicatrix recovery technique field, be specifically related to a kind of cicatrix and repair gel and preparation method thereof.
Background technology
" cicatrix " be the detrimental effect of the factors such as physics, biology, chemistry in human body skin soft tissue, cause skin soft tissue Major injury and can not the most normally repair, turning the outward appearance that i.e. affects that stayed by fibrous tissue replacement reparation affects again merit The local symptom of energy.What " cicatrix " brought to patient is that the huge human body is painful and psychic pain, especially burns, scalds, sternly The cicatrix left over after weight wound.Several years of scar hyperplasia phase almost allow patient suffer untold misery.The atrophy phase then makes again trouble Person's skin area, particularly face are changed beyond recognition, dysfunction, cause the great body of patient, heart double combination obstacle.
Keloid is swelled, and epidermis is warty hypertrophy, smooth surface, and color is ruddy and shinny, is often found to have the hair of expansion Thin blood vessel.Skin lesion is protruding from edge, Eriocheir sinensis foot shape.Skin injury size differs, appearance difference, and matter is hard, as Cartilage sample, more subjective symptoms is felt very to itch and is felt bad or have pain, burning sensation.Due to pain acumen, it may be teleneuron conduction Sensitive or micro-neuromatous formation, even clothes etc. touch gently and i.e. feel pain.Development is relatively slower, the most persistently increases, has Cicatrix epidermis and perienchyma shinny, color is the most white.The phenomenon bounced back the most voluntarily, has once in a while and cancerates.Keloid It is apt to occur in the positions such as breast, shoulder, neck, the back of the body and auricle.Although keloid is relatively conventional, but treat difficulty so far.Therefore, how to press down Make fibrocellular propagation, prevent it from recurring difficulty together with continuing to increase and having become current medical circle.
The most conventional treatment technology has 1. skin graftings, 2. laser therapy, 3. skin dilator treatment, 4. resection and suture operation Deng steroid hormone class Drug therapy, 7. cold therapies etc. such as surgical operations, 5. attrition, 6. use dexamethasone.These technology The symptom alleviating patient in various degree, in said method, non-drug therapy all exists costly, patient is more painful, hands The deficiencies such as art treatment time length, and use the steroid hormone class Drug therapys such as dexamethasone may health be damaged even Cause sterility and infertility, osteoporosis etc..
Summary of the invention
It is an object of the invention to provide a kind of cicatrix and repair gel and preparation method thereof, this scar repair agent can be the most moist And reparation scarred skin.
A kind of cicatrix repairs gel, is made up of the raw material of following portions by weight: heparin sodium 0.03 ~ 0.05 part, hyaluronic acid 0.04 ~ 0.06 part, Aloe powder 0.04 ~ 0.06 part, Semen Vitis viniferae extract 0.04 ~ 0.06 part, vitamin E 0.05 ~ 0.15 part, smoke Clothing grass oil 0.05 ~ 0.15 part, bisabolol 0.12 ~ 0.25 part, nicotiamide 0.35 ~ 0.7 part, carbomer 0.6 ~ 0.8 part, allantoin 0.8 ~ 1.3 part, Herba Centellae extract 0.8 ~ 1.3 part, glycerol 5 ~ 6.8 parts, solubilizing agent 1 ~ 1.4 part, nertralizer 0.2 ~ 0.8 part is fragrant Essence 0.05 ~ 0.15 part, preservative 0.25 ~ 0.35 part, 85 ~ 91 parts of water.
Preferably, above-mentioned cicatrix reparation gel is made up of the raw material of following portions by weight: heparin sodium 0.04 part, hyaluronic acid 0.05 part, Aloe powder 0.05 part, Semen Vitis viniferae extract 0.05 part, vitamin E 0.1 part, Oleum lavandula angustifolia 0.1 part, bisabolol 0.2 Part, nicotiamide 0.5 part, carbomer 0.7 part, allantoin 1 part, Herba Centellae extract 1 part, glycerol 6 parts, solubilizing agent 1.2 parts, neutralize Agent 0.7 part, 0.1 part of essence, preservative 0.3 part, 87.91 parts of water.
Preferably, described solubilizing agent is Cremophor RH40 and/or polysorbate-20, and described nertralizer is three Ethanolamine or potassium hydroxide, described preservative is methyl hydroxybenzoate and/or phenoxyethanol.
Above-mentioned cicatrix repairs the preparation method of gel, comprises the following steps:
(1) take appropriate water heparin sodium and a small amount of preservative to be soaked 15 ~ 30 minutes, obtain standby material 1；
(2) essence, Oleum lavandula angustifolia, solubilizing agent, vitamin E and bisabolol are stirred, obtain standby material 2；
(3) Semen Vitis viniferae extract, Herba Centellae extract, glycerol, allantoin, carbomer and hyaluronic acid are joined the water of surplus In, stirring, dissolve and be heated to 70 ~ 90 DEG C, constant temperature, after 25 ~ 40 minutes, is naturally cooling to 35 ~ 45 DEG C；
(4) in step (3) products therefrom add Aloe powder, nicotiamide, the preservative of surplus, step (1) gained standby material 1 and 2,35 ~ 45 DEG C of insulated and stirred of step (2) gained standby material 4 ~ 6 minutes, homogenizing 1 ~ 2 minute, it is cooled to room temperature；
(5) in step (4) products therefrom, add nertralizer, stir 20 ~ 40 minutes, to obtain final product.
Wherein, described heparin sodium, hyaluronic acid, Aloe powder, Semen Vitis viniferae extract, vitamin E, Oleum lavandula angustifolia, opopanax Alcohol, nicotiamide, carbomer, allantoin, Herba Centellae extract, glycerol, solubilizing agent, nertralizer, essence and preservative are commonly Commercially available prod, described water is deionized water.
Raw material of the present invention is easy to get, and preparation process is easy, and constant product quality is safe and non-stimulating, adding of skin-moisturizing, skin composition Entering, it is possible to gentle skin care, accelerate the reparation of damage skin, promote effect of damage skin healing, life-time service can be repaired Scarred skin, it is simple to large-scale industrial produces.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but protection scope of the present invention is not limited to this.
The Semen Vitis viniferae extract used in embodiment in detail below and Herba Centellae extract all select Zhengzhou litchi promise biological The product of Science and Technology Ltd.；Oleum lavandula angustifolia selects the product of Yi Li De Run agricultural development company limited.Semen Vitis viniferae extract is The antioxidation that finds in nature at present, the material that Scavenging ability is the strongest, freedom unnecessary in effectively removing human body Base, has the effect of superpower slow down aging and enhancing immunity, and antioxidation, antiallergic, resisting fatigue health invigorating, improvement Asia are good for Health state slow down aging, improve the symptom such as irritable, dizzy weak, hypomnesis.Herba Centellae extract has outstanding The effect that healing of wound and cicatrix are repaired, its reason is that asiaticoside has collage synthesis and new vascular generation, stimulation in promotion The important function such as granulation growth, so beneficially wound healing；Herba Centellae extract also has stronger antioxidation, can press down Free radical activity processed, desalinates melanin pigmentation, improves skin blood circulation, updates skin cell regeneration, helps melanin smooth Metabolism goes out external.Oleum lavandula angustifolia can be with heat-clearing and toxic substances removing, cleaning skin, wrinkle removal skin care, whitening and speckle dispelling, oil control and acne removal, reparation be sensitive, Improve sleep, strengthen active mood eye haustra-dsipelling black eye, may additionally facilitate the skin-protecting functions such as damaged tissues regeneration recovery.
Embodiment 1
A kind of cicatrix repairs gel, is made up of the raw material of following portions by weight: heparin sodium 0.04 part, hyaluronic acid 0.05 part, reed 0.05 part of luxuriant growth powder, Semen Vitis viniferae extract 0.05 part, vitamin E 0.1 part, Oleum lavandula angustifolia 0.1 part, bisabolol 0.2 part, nicotiamide 0.5 part, carbomer 0.7 part, allantoin 1 part, Herba Centellae extract 1 part, glycerol 6 parts, Cremophor RH40 1.2 parts, three Ethanolamine 0.7 part, 0.1 part of essence, methyl hydroxybenzoate 0.3 part, 87.91 parts of water.
Above-mentioned cicatrix repairs the preparation method of gel, comprises the following steps:
(1) take appropriate water and heparin sodium and a small amount of methyl hydroxybenzoate are soaked 20 minutes (for by heparin sodium maceration), obtain standby Material 1；
(2) essence, Oleum lavandula angustifolia, Cremophor RH40, vitamin E and bisabolol are stirred, obtain standby material 2；
(3) Semen Vitis viniferae extract, Herba Centellae extract, glycerol, allantoin, carbomer and hyaluronic acid are joined the water of surplus In, stirring, dissolve and be heated to 80 DEG C, constant temperature, after 30 minutes, is naturally cooling to 40 DEG C；
(4) in step (3) products therefrom, Aloe powder, nicotiamide, the methyl hydroxybenzoate of surplus, step (1) gained standby material 1 are added And step (2) gained standby material 2, stirring 5 minutes, homogenizing processes 1 minute, is cooled to room temperature；
(5) in step (4) products therefrom, add triethanolamine, stir 30 minutes, to obtain final product.
Using display continuously through several not specific users, the cicatrix of above-mentioned preparation is repaired water when gel is smeared and is moistened, clearly, no Greasy, absorb fast；For there being the user of cicatrix, take cicatrix reparation gel described in appropriate embodiment 1 and be applied directly at cicatrix, and Massage several minutes gently, until cicatrix is repaired gel and fully absorbed by skin, every day 2 ~ 3 times, use one week continuously, cicatrix color Shoaling, scar length has reduced, and after using one month, major part user's scar length is obviously reduced, some user's Scar eliminating medicine Mistake loses.
Embodiment 2
A kind of cicatrix repairs gel, is made up of the raw material of following portions by weight: heparin sodium 0.03 part, hyaluronic acid 0.04 part, reed 0.04 part of luxuriant growth powder, Semen Vitis viniferae extract 0.04 part, vitamin E 0.05 part, Oleum lavandula angustifolia 0.05 part, bisabolol 0.12 part, cigarette Amide 0.35 part, carbomer 0.6 part, allantoin 0.8 part, Herba Centellae extract 0.8 part, glycerol 5.18 parts, polysorbate-20 1 part, potassium hydroxide 0.2 part, 0.05 part of essence, methyl hydroxybenzoate 0.25 part, 90.4 parts of water.
Above-mentioned cicatrix repairs the preparation method of gel, comprises the following steps:
(1) take appropriate water and heparin sodium and a small amount of methyl hydroxybenzoate are soaked 20 minutes (for by heparin sodium maceration), obtain standby Material 1；
(2) essence, Oleum lavandula angustifolia, polysorbate-20, vitamin E and bisabolol are stirred, obtain standby material 2；
(3) Semen Vitis viniferae extract, Herba Centellae extract, glycerol, allantoin, carbomer and hyaluronic acid are joined the water of surplus In, stirring, dissolve and be heated to 80 DEG C, constant temperature, after 30 minutes, is naturally cooling to 40 DEG C；
(4) in step (3) products therefrom, Aloe powder, nicotiamide, the methyl hydroxybenzoate of surplus, step (1) gained standby material 1 are added And step (2) gained standby material 2, stirring 5 minutes, homogenizing processes 1 minute, is cooled to room temperature；
(5) in step (4) products therefrom, add potassium hydroxide, stir 30 minutes, to obtain final product.
Using display continuously through several not specific users, the cicatrix of above-mentioned preparation is repaired water when gel is smeared and is moistened, clearly, no Greasy, absorb fast；For there being the user of cicatrix, take cicatrix reparation gel described in appropriate embodiment 2 and be applied directly at cicatrix, and Massage several minutes gently, until cicatrix is repaired gel and fully absorbed by skin, every day 2 ~ 3 times, use one week continuously, cicatrix color Shoaling, scar length has reduced, and after using one month, major part user's scar length is obviously reduced, some user's Scar eliminating medicine Mistake loses.
Embodiment 3
A kind of cicatrix repairs gel, is made up of the raw material of following portions by weight: heparin sodium 0.05 part, hyaluronic acid 0.06 part, reed 0.06 part of luxuriant growth powder, Semen Vitis viniferae extract 0.06 part, vitamin E 0.15 part, Oleum lavandula angustifolia 0.15 part, bisabolol 0.25 part, cigarette Amide 0.7 part, carbomer 0.8 part, allantoin 1.3 parts, Herba Centellae extract 1.3 parts, glycerol 6 parts, polysorbate-20 1.4 Part, potassium hydroxide 0.2 part, 0.1 part of essence, phenoxyethanol 0.3 part, 87.12 parts of water..
Above-mentioned cicatrix repairs the preparation method of gel, comprises the following steps:
(1) take appropriate water and heparin sodium and a small amount of phenoxyethanol are soaked 20 minutes (for by heparin sodium maceration), obtain standby Material 1；
(2) essence, Oleum lavandula angustifolia, polysorbate-20, vitamin E and bisabolol are stirred, obtain standby material 2；
(3) Semen Vitis viniferae extract, Herba Centellae extract, glycerol, allantoin, carbomer and hyaluronic acid are joined the water of surplus In, stirring, dissolve and be heated to 80 DEG C, constant temperature, after 30 minutes, is naturally cooling to 40 DEG C；
(4) in step (3) products therefrom, Aloe powder, nicotiamide, the phenoxyethanol of surplus, step (1) gained standby material 1 are added And step (2) gained standby material 2, stirring 5 minutes, homogenizing processes 1 minute, is cooled to room temperature；
(5) in step (4) products therefrom, add potassium hydroxide, stir 30 minutes, to obtain final product.
Using display continuously through several not specific users, the cicatrix of above-mentioned preparation repairs water profit when gel is smeared, delicate fragrance, no Greasy, absorb fast；For there being the user of cicatrix, take cicatrix reparation gel described in appropriate embodiment 3 and be applied directly at cicatrix, and Massage several minutes gently, until cicatrix is repaired gel and fully absorbed by skin, every day 2 ~ 3 times, use 5 days continuously, cicatrix color Substantially shoaling, scar length has reduced, and after using one month, major part user's scar length is obviously reduced, some user's scar Trace is vanished from sight.

Claims (4)

1. a cicatrix repairs gel, it is characterised in that be made up of the raw material of following portions by weight: heparin sodium 0.03 ~ 0.05 part, Hyaluronic acid 0.04 ~ 0.06 part, Aloe powder 0.04 ~ 0.06 part, Semen Vitis viniferae extract 0.04 ~ 0.06 part, vitamin E 0.05 ~ 0.15 part, Oleum lavandula angustifolia 0.05 ~ 0.15 part, bisabolol 0.12 ~ 0.25 part, nicotiamide 0.35 ~ 0.7 part, carbomer 0.6 ~ 0.8 Part, allantoin 0.8 ~ 1.3 part, Herba Centellae extract 0.8 ~ 1.3 part, glycerol 5 ~ 6.8 parts, solubilizing agent 1 ~ 1.4 part, nertralizer 0.2 ~ 0.8 part, 0.05 ~ 0.15 part of essence, preservative 0.25 ~ 0.35 part, 85 ~ 91 parts of water.
2. cicatrix as claimed in claim 1 repairs gel, it is characterised in that be made up of the raw material of following portions by weight: heparin 0.04 part of sodium, hyaluronic acid 0.05 part, Aloe powder 0.05 part, Semen Vitis viniferae extract 0.05 part, vitamin E 0.1 part, lavandula angustifolia Oil 0.1 part, bisabolol 0.2 part, nicotiamide 0.5 part, carbomer 0.7 part, allantoin 1 part, Herba Centellae extract 1 part, glycerol 6 Part, solubilizing agent 1.2 parts, nertralizer 0.7 part, 0.1 part of essence, preservative 0.3 part, 87.91 parts of water.
3. cicatrix as claimed in claim 1 or 2 repairs gel, it is characterised in that: described solubilizing agent is PEG-40 hydrogenated castor Oil and/or polysorbate-20, described nertralizer is triethanolamine or potassium hydroxide, described preservative be methyl hydroxybenzoate and/or Phenoxyethanol.
4. as described in arbitrary in claims 1 to 3, cicatrix repairs the preparation method of gel, it is characterised in that comprise the following steps:
(1) take appropriate water heparin sodium and a small amount of preservative to be soaked 15 ~ 30 minutes, obtain standby material 1；
(2) essence, Oleum lavandula angustifolia, solubilizing agent, vitamin E and bisabolol are stirred, obtain standby material 2；
(3) Semen Vitis viniferae extract, Herba Centellae extract, glycerol, allantoin, carbomer and hyaluronic acid are joined the water of surplus In, stirring, dissolve and be heated to 70 ~ 90 DEG C, constant temperature, after 25 ~ 40 minutes, is naturally cooling to 35 ~ 45 DEG C；
(4) in step (3) products therefrom add Aloe powder, nicotiamide, the preservative of surplus, step (1) gained standby material 1 and 2,35 ~ 45 DEG C of insulated and stirred of step (2) gained standby material 4 ~ 6 minutes, homogenizing 1 ~ 2 minute, it is cooled to room temperature；
(5) in step (4) products therefrom, add nertralizer, stir 20 ~ 40 minutes, to obtain final product.
CN201610483292.8A 2016-06-28 2016-06-28 A kind of cicatrix repairs gel and preparation method thereof Pending CN106138521A (en)

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CN110302414A (en) * 2019-08-20 2019-10-08 广西信业生物技术有限公司 A kind of medical scar repairs silicone gel dressing and preparation method
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CN107158358A (en) * 2017-07-10 2017-09-15 东北林业大学 A kind of anti-trick rhagadia cream of hazelnut oil and preparation method thereof
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CN111920742A (en) * 2020-09-18 2020-11-13 微著生物科技(东营)有限责任公司 Chitosan multi-effect repair mask and preparation method thereof
CN114644764A (en) * 2020-12-21 2022-06-21 广东达成弘业生物科技有限公司 UV (ultraviolet) photocuring hydrogel and preparation method thereof
CN113208989A (en) * 2021-03-31 2021-08-06 湖北神丹健康食品有限公司 Preserved egg gel paste and preparation method thereof
CN113208989B (en) * 2021-03-31 2023-06-27 湖北神丹健康食品有限公司 Preserved egg gel paste and preparation method thereof
CN113662881A (en) * 2021-09-30 2021-11-19 水羊化妆品制造有限公司 Composition for repairing sensitive skin, preparation method and application thereof
CN115670989A (en) * 2021-12-15 2023-02-03 上海优萃生物科技有限公司 Composition capable of rapidly promoting rapid repair of scars and acne marks
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