CN110215415A - Low viscous submicron emulsion of one kind and the preparation method and application thereof - Google Patents
Low viscous submicron emulsion of one kind and the preparation method and application thereof Download PDFInfo
- Publication number
- CN110215415A CN110215415A CN201910349925.XA CN201910349925A CN110215415A CN 110215415 A CN110215415 A CN 110215415A CN 201910349925 A CN201910349925 A CN 201910349925A CN 110215415 A CN110215415 A CN 110215415A
- Authority
- CN
- China
- Prior art keywords
- oil
- submicron emulsion
- low viscous
- homogeneous
- emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000839 emulsion Substances 0.000 title claims abstract description 100
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- 238000010521 absorption reaction Methods 0.000 claims abstract description 30
- 239000000126 substance Substances 0.000 claims abstract description 26
- 239000004094 surface-active agent Substances 0.000 claims abstract description 25
- 239000004615 ingredient Substances 0.000 claims abstract description 20
- 239000002537 cosmetic Substances 0.000 claims abstract description 19
- 239000004519 grease Substances 0.000 claims abstract description 14
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 13
- 239000003755 preservative agent Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000006210 lotion Substances 0.000 claims description 40
- 239000003921 oil Substances 0.000 claims description 25
- 235000019198 oils Nutrition 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 16
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- 240000000528 Ricinus communis Species 0.000 claims description 9
- 235000004443 Ricinus communis Nutrition 0.000 claims description 9
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 8
- 238000004945 emulsification Methods 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 6
- 239000000498 cooling water Substances 0.000 claims description 6
- 239000004006 olive oil Substances 0.000 claims description 6
- 235000008390 olive oil Nutrition 0.000 claims description 6
- 229920000570 polyether Polymers 0.000 claims description 6
- 239000004359 castor oil Substances 0.000 claims description 5
- 235000019438 castor oil Nutrition 0.000 claims description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- -1 sucrose Ester Chemical class 0.000 claims description 5
- 239000011782 vitamin Substances 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims description 4
- 239000002738 chelating agent Substances 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 4
- 229940051250 hexylene glycol Drugs 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 229930003799 tocopherol Natural products 0.000 claims description 4
- 235000010384 tocopherol Nutrition 0.000 claims description 4
- 229960001295 tocopherol Drugs 0.000 claims description 4
- 239000011732 tocopherol Substances 0.000 claims description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims description 3
- 241000557821 Azadirachta Species 0.000 claims description 3
- 244000052909 Dioscorea esculenta Species 0.000 claims description 3
- 240000007575 Macadamia integrifolia Species 0.000 claims description 3
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims description 3
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims description 3
- 235000017011 Mandorlo dulce Nutrition 0.000 claims description 3
- 244000076313 Mandorlo dulce Species 0.000 claims description 3
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 3
- 244000044822 Simmondsia californica Species 0.000 claims description 3
- 235000019486 Sunflower oil Nutrition 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 235000021302 avocado oil Nutrition 0.000 claims description 3
- 239000008163 avocado oil Substances 0.000 claims description 3
- 239000008169 grapeseed oil Substances 0.000 claims description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 3
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002600 sunflower oil Substances 0.000 claims description 3
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 2
- 240000008530 Rosa canina Species 0.000 claims description 2
- 235000000539 Rosa canina Nutrition 0.000 claims description 2
- 235000010337 Rosa dumalis Nutrition 0.000 claims description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 229940042585 tocopherol acetate Drugs 0.000 claims description 2
- 244000294611 Punica granatum Species 0.000 claims 1
- 235000014360 Punica granatum Nutrition 0.000 claims 1
- YAVVGPBYBUYPSR-UHFFFAOYSA-N benzene;oxygen Chemical compound [O].C1=CC=CC=C1 YAVVGPBYBUYPSR-UHFFFAOYSA-N 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 238000010200 validation analysis Methods 0.000 abstract description 3
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 34
- 210000003491 skin Anatomy 0.000 description 30
- 238000012360 testing method Methods 0.000 description 26
- 239000002245 particle Substances 0.000 description 19
- 229940108325 retinyl palmitate Drugs 0.000 description 17
- 235000019172 retinyl palmitate Nutrition 0.000 description 17
- 239000011769 retinyl palmitate Substances 0.000 description 17
- 239000000047 product Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 11
- 239000012071 phase Substances 0.000 description 10
- 238000009826 distribution Methods 0.000 description 9
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 8
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 8
- 235000019155 vitamin A Nutrition 0.000 description 8
- 239000011719 vitamin A Substances 0.000 description 8
- 229940045997 vitamin a Drugs 0.000 description 8
- 230000003712 anti-aging effect Effects 0.000 description 7
- 238000005119 centrifugation Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000002390 adhesive tape Substances 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 238000000265 homogenisation Methods 0.000 description 5
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 4
- 229960001777 castor oil Drugs 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 239000012086 standard solution Substances 0.000 description 4
- UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 description 4
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 4
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 229960005323 phenoxyethanol Drugs 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 229920002385 Sodium hyaluronate Chemical class 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical class [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 150000003712 vitamin E derivatives Chemical class 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- AXPZIVKEZRHGAS-UHFFFAOYSA-N 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1OC(=O)C(CC=2C=CC=CC=2)C1 AXPZIVKEZRHGAS-UHFFFAOYSA-N 0.000 description 1
- 240000005002 Erythronium dens canis Species 0.000 description 1
- 229920000289 Polyquaternium Polymers 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- JSXROLUNEDJZJE-UHFFFAOYSA-N acetic acid;phenol Chemical class CC(O)=O.OC1=CC=CC=C1 JSXROLUNEDJZJE-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- DTTVNCZEOYSFFF-UHFFFAOYSA-N ethoxyurea Chemical compound CCONC(N)=O DTTVNCZEOYSFFF-UHFFFAOYSA-N 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 230000002687 intercalation Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 231100000435 percutaneous penetration Toxicity 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000037067 skin hydration Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of low viscous submicron emulsions and the preparation method and application thereof, and low viscous submicron emulsion is made of the raw material of following mass percentage through super-pressure nanometer homogeneous: 1) water and water soluble ingredient 35%~99.5%；2) moisturizing grease 0.1%~30%；3) oil-soluble active UV absorption indicator substance 0.1%~15%；4) surfactant 0.1%~15%；5) preservative 0.2%~5%；The sum of mass percent of said components is 100%.Preparation method is included the following steps: to prepare water phase and oily phase respectively, be obtained using extra-high-pressure nano homogenizer emulsifying.Low viscous submicron emulsion contains various high-efficiency activated skin care ingredients, in the cosmetics applied to different systems, so that making an addition to active skincare substance in cosmetics is able to the effect of playing its active skincare, and with scientific its effective skin care of method validation.
Description
Technical field
The present invention relates to a kind of cosmetics, skin care item technology, more particularly to a kind of low viscous submicron emulsion and preparation method thereof
With application, a kind of skin care item of low viscous submicron emulsion system are such as prepared, a kind of active skincare group of submicron emulsion can also be prepared
Point, it makes an addition in all kinds of skin care item.
Background technique
As the cosmetology consciousness of people is also gradually increased, demand of the consumer to cosmetics is more and more, selection
It is more and more, and require more and more, have to product efficacy and more and more specifically more clearly require, to product appearance and skin sense
Etc. sensory experiences also increasingly pay attention to.The slim and graceful luxurious effect skin care item of skin sense come into being.Such skin care quality sense is salubrious, easily
By percutaneous absorption, there is special nursing role to skin.
In addition to safety, the also concern increasingly by consumer and manufacturer of the validity of cosmetics." cosmetics
Effect declares verification guide principle " (exposure draft) to effect declare verifying principle, method and all elements carried out it is bright
Really specification.During cosmetic industry fast development, the function subdivision trend of product is more obvious, cosmetic industry evaluation
It is to its both effectiveness effective means for declaring to carry out scientific support, essence is to declare to provide corresponding card for the effect of cosmetics
According to and foundation.By the development evolvement of many years, gradually perfect, the national prison of China safety evaluation of cosmetics system
Also gradually thus preceding product hygienic quality of focusing on is transferred to concern Product quality and safety to management thought, and measuring means is also experiencing
From traditional product toxicology test to reinforcement raw materials control, carries out more scientific risk assessment and introduce substitution detection method
Transformation.Cosmetic industry evaluation can be by a variety of methods such as biochemistry, cell biology, clinical evaluation to cosmetic industry
Carry out integration test, reasonable analysis and scientific explarnation.It is objective in addition to the experimental program for formulating scientific and precise in evaluation procedure
Evaluation appts also become essential a part in appraisal.Common effect detection has whitening, crease-resistant, anti-aging, tight
The effect of skin and other effects skin care item is caused to be detected.
Product efficacy passes through active skincare ingredients progress Transdermal absorption and plays a role to realize validity of products, and active
The percutaneous absorbtion amount and percutaneous absorbtion rate of skin care ingredient are then particularly important.The cuticula of epidermis is the main screen of Transdermal absorption
Barrier, foreign bodies through cuticula speed be also percutaneous absorbtion main rate-limiting step.In general, molecular weight is less than 300,
Positively charged substance is easy to permeate if having both fat-soluble and certain water solubility.As azone substance can improve cuticula
Percutaneous absorbtion rate can be greatly improved in permeability.The percutaneous absorbtion of functional component is more, and product effect is better, and product efficacy obtains most
The performance of limits.
Under normal circumstances, influence the factor of percutaneous absorbtion: (1) depend on transdermal substance itself characteristic: as molecular weight,
Polarity, the fat-soluble and factors such as water-soluble；(2) cuticula has storage cavern effect to the substance of percutaneous absorbtion, can store moieties,
These substance a part will be slowly absorbed, and another part will be rinsed or be taken away by skin friction；(3) matrix dosage form exists
The absorption process of transdermal substance is influenced to a certain extent: the 1. influence to skin hydration effect: cuticula energy under certain condition
Continue excessive absorption moisture, referred to as aquation.Water imbibition matrix and emulsified bases have water suction and water signature, be easy with
Skin secretion mixing, emulsification, are conducive to cuticula and are in hydration status, weaken its barrier action；2. the affinity with matrix
Power: it when matrix is big with transdermal substance affinity and forms soluble complex, discharges and slows down from matrix；On the contrary then affinity
Small, release is accelerated, and absorbs and increases；3. transdermal substance and skin contact area: in two-phase matrix, such as oil-in-water type or Water-In-Oil
Type, it is necessary to enable nutrient to have higher distribution coefficient in foreign minister, so that the substance can be conducive to skin surface close contact
It absorbs.4. the pH value of matrix can influence the percutaneous absorbtion of weak electrolyte, when matrix pH value is less than the pKa of acidic materials or is greater than alkali
Property object pKa when, which exists with molecular forms, fat-soluble to become larger, and is conducive to absorb.
Submicron emulsion submicron emulsion (SE), partial size in the new emulsion for 0.1 μm~1 μm, have compared with
High load medicine and encapsulation rate, by using Submicron Emulsion as active carrier, it is intended to prepare a kind of with partial size appropriate, biology benefit
Expenditure is high, good absorbing, safety and stability, bland New Emulsion, and a new way efficiently, safe can be opened up for skin care item
Diameter.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of low viscous submicron emulsions, containing each
The high-efficiency activated skin care ingredient of kind.
The second object of the present invention is to provide a kind of ultralow viscous submicron emulsion containing various high-efficiency activated skin care ingredients
The preparation method of system in the cosmetics applied to different systems, is sent out so that making an addition to active skincare substance in cosmetics
The effect of waving its active skincare.
The third object of the present invention is to provide a kind of low viscous submicron emulsion Transdermal absorption in skin care item, cosmetics and answers
With method, using its effective skin care of the method validation of science.
An object of the present invention adopts the following technical scheme that realization: a kind of low viscous submicron emulsion, by following quality percentage
The raw material of number meter is made through super-pressure nanometer homogeneous:
The sum of mass percent of said components is 100%.
Further, the water soluble ingredient is in chelating agent, single or polyols blend, water-soluble actives
The composition of one or more kinds of arbitrary proportion mixing.
Further, the moisturizing grease be selected from Sucrose acetoisobutyrate, castor bean, Castor oil, jojoba seed oil,
Olive oil, Queensland nut seed oil, olive oil, saualane, avocado oil, grape seed oil, sunflower oil, dog rose fruit oil,
Lavender oil, Prunus Amygdalus Dulcis Oil, oat kernel oil, thorn A Ganshu benevolence oil, granada seed oil, azadirachta seed be oily, one in white pond flower seed oil
Kind or the composition of two or more arbitrary proportions mixing.
Further, the oil-soluble active UV absorption indicator substance is selected from vitamin A derivatives, tocopherol, fertility
The combination of one or more of phenol acetic acid esters, vitamine C palmitate, ascorbyl palmitate arbitrary proportion mixing
Object.
Further, the surfactant is selected from rilanit special 40, rilanit special 60, PPG-26- butylol polyether-
26, the composition of one or more of solubilizer LRI arbitrary proportion mixing.
Further, the preservative be selected from methyl hydroxybenzoate, Phenoxyethanol, Sensiva SC50, benzyl alcohol, pentanediol,
The composition of one or more of hexylene glycol, pungent glycol, olein arbitrary proportion mixing.
The second object of the present invention adopts the following technical scheme that realization: a kind of preparation method of low viscous submicron emulsion, including
Following steps:
1) water and water soluble ingredient of formula ratio under room temperature, is added, is dispersed with stirring and dissolves, forms system A；
2) moisturizing grease, oil-soluble active UV absorption indicator substance and the surface under room temperature, adding formula ratio are living
Property agent, stir evenly, formed system B；
3) system B is added in system A room temperature, stirs homogeneous, and emulsification is uniform；Or system A, B is separately heated to 75
~80 DEG C, homogeneous is stirred, uniformly, it is stand-by that room temperature is down in stirring for emulsification；The preservative for finally successively adding formula ratio again, obtains general
Logical homogeneous lotion；
4) it uses extra-high-pressure nano homogenizer emulsifying: setting the condition of extra-high-pressure nano homogenizer, received with super-pressure
Rice homogenizer carries out homogeneous to common homogeneous lotion obtained by step 3), to prepare low viscous submicron emulsion.
Further, it is 20 DEG C that the condition of the step 4) extra-high-pressure nano homogenizer, which is the temperature of cooling water circulation,；If
Determine host high-pressure pump: 1500bar, low pressure automatic adjustment are as follows: 32/33bar.
Further, it is repeated homogeneous 2-9 times using the step 4).
An object of the present invention adopts the following technical scheme that realization: the low viscous submicron emulsion of one kind is in skin care item, cosmetics
The application of middle Transdermal absorption.
Compared with prior art, the beneficial effects of the present invention are:
(1) a kind of preparation method of ultralow viscous submicron emulsion system containing various high-efficiency activated skin care ingredients is provided, is answered
In cosmetics for different systems, it is able to play the function of its active skincare so that making an addition to active skincare substance in cosmetics
Effect, and with scientific its effective skin care of method validation.Prepared by concrete application super-pressure nanotechnology a kind of low glues high-efficiency activated shield
The submicron emulsion system of skin ingredient provides a kind of Research Thinking of skin-care effect for being effectively improved daily use chemicals skin care item.Super-pressure is equal
Matter number is more, and product cut size is smaller, and the influence after homogeneous 3 times to product cut size size is little.Extra-high-pressure nano homogenizer
Condition set: cooling water circulation temperature as 20 DEG C；Set host high-pressure pump: 1500bar, low pressure automatic adjustment are as follows: 32/
33bar, to prepare super-pressure nanometer homogeneous lotion.
(2) through experimental exploring it is found that preparing the proportion that stable submicron emulsion key is oily phase and surfactant, i.e.,
The grease and water-soluble substances of equivalent, the surfactant of addition is more, and the partial size of lotion is smaller more stable.The molten substance of oil it is total
Content is within 3 times of surface-active contents or when lower loading, and the partial size of available solution is smaller, more concentrates, is steady
Fixed submicron emulsion.Because emulsifier is bigger, the micella of formation is more, and emulsion particle is also more, and latex particle size is got over
It is small.
Although ordinary emulsion can obtain stable submicron emulsion by adding more surfactants, addition is more
Surfactant, formulation cost increases, and the irritation of product also increases, and particle diameter distribution is still relatively wide, but receives by super-pressure
Rice homogenizer homogenization emulsion particle diameter it is smaller, the additive amount of surfactant is lower, and product is more stable, active skincare at
The percutaneous absorbtion amount divided is higher.
(3) it finds after tested, takes the ordinary emulsion and sub-micro that the oil of ambient stable is mutually 1:1 with the proportion of surfactant
Lotion compares test, obtains the uptake and absorption rate of both；Submicron emulsion transdermal absorption factor can be than traditional cream
Liquid is high.
Detailed description of the invention
Fig. 1 is the particle diameter distribution of the common homogeneous lotion of embodiment 1；
The emulsion particle diameter that Fig. 2 is 1 extra-high-pressure nano homogenizer homogeneous of embodiment 1 time is distributed；
The emulsion particle diameter that Fig. 3 is 1 extra-high-pressure nano homogenizer homogeneous of embodiment 3 times is distributed；
The emulsion particle diameter that Fig. 4 is 1 extra-high-pressure nano homogenizer homogeneous of embodiment 5 times is distributed；
The emulsion particle diameter that Fig. 5 is 1 extra-high-pressure nano homogenizer homogeneous of embodiment 7 times is distributed；
The emulsion particle diameter that Fig. 6 is 1 extra-high-pressure nano homogenizer homogeneous of embodiment 9 times is distributed；
Fig. 7 is the emulsion particle diameter distribution of surfactant/oil phase=1/3 in the low viscous submicron emulsion of embodiment 2；
Fig. 8 is the absorbance value standard concentration curve of Retinol Palmitate；
Fig. 9 is that the external residual quantity of Retinol Palmitate changes over time curve；
Figure 10 is the external residual quantity percentage column figure of P18-1, P18-2-3 lotion；
Figure 11 is the partial size state of two kinds of lotions in the anti-ageing submicron emulsion of 3 vitamin A of example；
Figure 12 is the partial size state that 4 vitamin E of example nourishes two kinds of lotions in submicron emulsion.
Specific embodiment
In the following, being described further in conjunction with attached drawing and specific embodiment to the present invention, it should be noted that not
Under the premise of conflicting, new implementation can be formed between various embodiments described below or between each technical characteristic in any combination
Example.
In the present invention, if not refering in particular to, all parts, percentage are unit of weight, used equipment and raw material etc.
It is commercially available or commonly used in the art.Method in following embodiments is unless otherwise instructed the normal of this field
Rule method.
A kind of low viscous submicron emulsion is made of the raw material of following mass percentage through super-pressure nanometer homogeneous:
The sum of mass percent of said components is 100%.
As further preferred scheme, the water soluble ingredient is more selected from chelating agent (such as EDETATE SODIUM), single or mixing
(water soluble humectants are as urinated for first alcohol (such as dipropylene glycol, propylene glycol, sorbierite, butanediol, glycerol) and water-soluble actives
Element, ethoxy urea, trehalose, polyquaternium -51, tremella polysaccharides, Sodium Hyaluronate, carbohydrate isomer, water solubility
Extract etc.) one or more of arbitrary proportion mixing composition.
As further preferred scheme, the moisturizing grease be selected from Sucrose acetoisobutyrate, castor bean, Castor oil,
Jojoba seed oil, olive oil, Queensland nut seed oil, olive oil, saualane, avocado oil, grape seed oil, sunflower oil, dog
Tooth cynarrhodion oil, lavender oil, Prunus Amygdalus Dulcis Oil, oat kernel oil, thorn A Ganshu benevolence oil, granada seed oil, azadirachta seed oil, Bai Chihua
The composition of one or more of seed oil arbitrary proportion mixing.
As further preferred scheme, the oil-soluble active UV absorption indicator substance is selected from retinyl palmitate etc.
The vitamin e derivatives such as vitamin A derivatives, tocopherol, tocopherol acetate, vitamine C palmitate, ascorbic acid palm
The composition of one or more of acid esters arbitrary proportion mixing.
As further preferred scheme, the surfactant is selected from emulsifier (such as Sucrose Acetate acid sucrose of high hlb
Ester), one of solubilizer (such as rilanit special 40, rilanit special 60, PPG-26- butylol polyether -26, solubilizer LRI)
Or the composition of two or more arbitrary proportion mixing.
As further preferred scheme, the preservative is selected from methyl hydroxybenzoate, Phenoxyethanol, Sensiva SC50, benzene first
The composition of one or more of alcohol, pentanediol, hexylene glycol, pungent glycol, olein arbitrary proportion mixing.
It is specific embodiment of the present invention below, used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained by buying pattern outside fixed.
A kind of embodiment 1: low viscous submicron emulsion
Table 1 is the formula composition of the low viscous submicron emulsion of embodiment 1
| Standard Chinese name | Mass percentage % |
| Water | 79.7 |
| Butanediol (water soluble ingredient) | 8 |
| Retinyl palmitate (oil-soluble active UV absorption indicator substance) | 0.1 |
| Sucrose acetoisobutyrate (moisturizing grease) | 2.9 |
| Castor-oil plant (Ricinus Communis) seed oil (moisturizing grease) | 5 |
| Solubilizer LRI (surfactant) | 4 |
| Methyl hydroxybenzoate (preservative) | 0.3 |
Note: the INCI title of solubilizer LRI: Cremophor RH40/- 26/ water of PPG-26- butylol polyether
A kind of embodiment 2: low viscous submicron emulsion
Table 2 is the formula composition of the low viscous submicron emulsion of embodiment 2
Note: the INCI title of solubilizer LRI: Cremophor RH40/- 26/ water of PPG-26- butylol polyether
The formula of embodiment 2 and embodiment 1 be formulated the difference is that only lipophilic component content is different, form 3 emulsion systems
(being shown in Table 2), each system complete step 1) -3 in preparation method), common homogeneous emulsion fraction storage sample, remaining major part is made
The extra-high-pressure nano homogenizer emulsifying for carrying out step 4), is repeated 3 times, and test result comparison is shown in Table 4.
The preparation method of the low viscous submicron emulsion of embodiment 1-2, includes the following steps:
1) water and water soluble ingredient of formula ratio under room temperature, is added, is dispersed with stirring and dissolves, forms system A；
2) moisturizing grease, oil-soluble active UV absorption indicator substance and the surface under room temperature, adding formula ratio are living
Property agent, stir evenly, formed system B；
3) system B is added in system A room temperature, stirs homogeneous, and emulsification is uniform；Or system A, B is separately heated to 75
~80 DEG C, homogeneous is stirred, uniformly, it is stand-by that room temperature is down in stirring for emulsification；The preservative for finally successively adding formula ratio again, obtains general
Logical homogeneous lotion；It leaves and takes part and is used as test；
4) it uses extra-high-pressure nano homogenizer emulsifying: setting the condition of extra-high-pressure nano homogenizer: cooling water circulation
Temperature be 20 DEG C；Setting host high-pressure pump: 1500bar (can beat) in operation between 1460~1536, low pressure automatic adjustment
Are as follows: 32/33bar；Homogeneous, homogeneous 0-9 are carried out to common homogeneous lotion obtained by step 3) with extra-high-pressure nano homogenizer
It is secondary, to prepare low viscous submicron emulsion.
5) it takes out step 3) and 4) resulting partial emulsion carries out centrifugal stability test, centrifugal condition: centrifugation rate
3000r/min, length of testing speech 30min, quickly judge emulsion intercalation method；
6) step 3) and 4) resulting partial emulsion are taken out and carries out partial size with Bettersize2000B laser fineness gage
Distribution tests quickly judge the particle diameter distribution situation of lotion.
The effect assessment and performance detection of embodiment 1-2
1. detecting to the performance of the low viscous submicron emulsion of embodiment 1, detection project and result are referring to table 3 and Fig. 1-
6。
The change of size comparison of the different homogenization cycles of table 3
Step 3) is prepared into above-mentioned formula system, i.e., it is ordinary emulsion that homogenization cycles, which are 0 gained, using super-pressure nanometer
Low viscous submicron emulsion obtained by homogenizer emulsifying, discovery super-high-pressure homogenization number is more, and product cut size is smaller (being shown in Table 3), grain
Diameter change procedure is shown in Fig. 1-6, it is known that the influence after homogeneous 3 times to product cut size size is little.
It as shown in figures 1 to 6, is the change of size mistake with a batch of common homogeneous lotion and super-pressure nanometer homogeneous lotion
Journey, it is known that common homogeneous emulsion particle diameter is larger relatively to be dispersed, and is more concentrated by the more partial sizes of extra-high-pressure nano homogenizer homogenization cycles
The analysis offset small toward partial size.
2. the performance of the low viscous submicron emulsion of pair embodiment 2 detects, detection project and result are referring to table 4.
The state vs of 4 different content surface active agent emulsions of table
As shown in Table 4, when surfactant/oil phase=1/1, common low viscous emulsion particle diameter is larger, super-pressure nanometer homogeneous
Emulsion particle diameter is smaller more to be concentrated；When the molten active matter of oil is 2 times of surfactant or higher ratio, common low slimy milk liquid is unstable
It is fixed, super-pressure nanometer homogeneous emulsion-stabilizing, it is known that the shakiness of low level of surfactant can be made using extra-high-pressure nano homogenizer
Determine lotion to become stable, it is possible to reduce the application of lotion Surfactant.
3. 3 sections of nanometer homogeneous lotions (homogeneous 3 times) obtained by pair embodiment 2, with Bettersize2000B laser particle size
Distribution instrument carries out particle diameter distribution test, quickly judges the particle diameter distribution situation of lotion, as a result as follows:
The partial size of 5 different content surface active agent emulsions of table compares
Tested above it is found that the total content of the molten substance (moisturizing grease) of oil be within 3 times of surface-active contents or
When lower loading, the stable submicron emulsion that its partial size of lotion smaller (being shown in Table 5) more concentrates (see Fig. 7) can be obtained.(when the molten object of oil
When the total content of matter is 4 times of surfactant, obtained emulsion particle diameter is not in the range of submicron emulsion, not as ours
Research object)
In conclusion by table 2, table 4 and table 5 it is found that the molten active material of oil and water-soluble object of equal volume in embodiment 2
Matter can be such that the unstable lotion of low level of surfactant becomes stable, can reduce cream using extra-high-pressure nano homogenizer homogeneous
The application of liquid Surfactant reduces formulation cost and the stimulation of surfactant bring, obtains the smaller milder of partial size more
Stable lotion.
4. characterizing the percutaneous absorptivity of submicron emulsion
Vitamin is commonly used in skin care item and its derivative carrys out skin care, and the bioactivity of vitamin A is mainly reflected in maintenance machine
A variety of skin care anti-aging functions, the vitamin Es such as growth, the complete, inhibition of lipid peroxidation of maintenance epidermis of body have anti-aging, resist
Peroxidating and the effect of ultraviolet injury resistant.The oil that vitamin A derivatives or vitamin e derivative etc. have UV absorption can be added
Melt into point is prepared into submicron emulsion, and carries out percutaneous penetration.This test object (is also known as regarded with Retinol Palmitate
Flavol palmitate) for, including following characteristics content:
A, prepare the standard solution of Retinol Palmitate: 10.00 μ g/mL Retinol Palmitate standards of selection are molten
Liquid carries out ultraviolet absorption peak scanning with ultraviolet permeability analyzer UV-2000S in 400-220nm wave-length coverage, obtains it most
Big absorbing wavelength is 326nm；The absorbance value under 326nm is read, Retinol Palmitate absorbance value-mass concentration is drawn
Curve, obtained Retinol Palmitate standard curve are y=0.0866x-0.00112, R2=0.998.
B, position first is chosen in experimenter's forearm health skin, having a size of 4cm2Square, it is with cotton swab that lotion is uniform
It is applied in sampling range, makes the coating weight 0.020g of lotion；
C, sample time is 0.5h, 1h, 1.5h, 2h, after reaching sample time, not with adhesive tape removing corresponding sample range
Absorbed lotion；
D, adhesive tape is put into the air-tight bottle of brown after removing, accurately pipettes 25.00mL dehydrated alcohol into air-tight bottle, is used
SK1200E ultrasonic cleaner ultrasound 30min；
E, the external residual lotion that elution is gone out with adhesive tape avulsion, obtains a series of samples to be measured, with ultraviolet permeability point
Analyzer UV-2000S measures absorbance value of the sample liquid at 326nm.
In this experiment, the formula of the low viscous submicron emulsion of vitamin A is as follows:
The low viscous submicron emulsion formula table of 6 vitamin A of table
| Standard Chinese title | Content % |
| Water | 83.65 |
| Butanediol (water soluble ingredient) | 8 |
| EDETATE SODIUM (water soluble ingredient) | 0.05 |
| Castor-oil plant (Ricinus Communis) seed oil (moisturizing grease) | 3 |
| Retinyl palmitate (oil-soluble active UV absorption indicator substance) | 1 |
| - 26/ water of Cremophor RH40/butylol polyether (surfactant) | 4 |
| Methyl hydroxybenzoate (preservative) | 0.3 |
The experiment carries out percutaneous absorbtion simulation test, same formula system system using Retinol Palmitate as identifying object
The ordinary emulsion obtained is labeled as P18-1, is labeled as P18- with by 3 obtained submicron emulsions of extra-high-pressure nano homogenizer homogeneous
2-3 verifies the Transdermal absorption situation of the active constituent of two lotion.
The process of percutaneous absorbtion simulation test:
1) it prepares the standard solution of Retinol Palmitate: accurately weighing the Retinol Palmitate standard specimen of certain mass
In beaker, appropriate dehydrated alcohol dissolution is added.Be made into mass concentration be 6.00 μ g/mL, 7.00 μ g/mL, 8.00 μ g/mL,
9.00 μ g/mL, 10.00 μ g/mL standard solution.
2) 10.00 μ g/mL Retinol Palmitate standard solution are selected, are existed with ultraviolet permeability analyzer UV-2000S
Ultraviolet absorption peak scanning is carried out in 400-220nm wave-length coverage, obtains a length of 326nm of maximum absorption wave；
3) with the absorbance of the Retinol Palmitate reference substance of purple light spectrophotometric determination known concentration, abscissa
For the concentration of reference substance, ordinate is absorbance, reads the absorbance value under 326nm, fits standard according to the result measured
Concentration curve, obtained regression equation are as follows: A=0.0866C-0.00112, R2=0.998.It is as shown in Figure 8 to draw standard curve.
4) before doing serial experiment, we choose t=0.5h carry out preliminary experiment, find the Transdermal absorption time in 0.5h,
The Transdermal absorption percentage difference of P18-1 and P18-2-3 lotion is 1.5% or so, therefore in subsequent serial experiment, inhaling
It is appropriately extended between time receiving, chooses 0.5h, 1h, 1.5h, 2h respectively and tested as soak time.
5) sampling point is chosen in experimenter's forearm, having a size of 4cm2Square, lotion is uniformly applied to sampling with cotton swab
In range, make the coating weight 0.020g of lotion, sample time 0.5h, 1h, 1.5h, 2h, after reaching sample time, uses adhesive tape
The unabsorbed lotion of corresponding sample range is removed, adhesive tape is put into the air-tight bottle of brown after removing, accurately pipettes 25.00mL
Dehydrated alcohol is into air-tight bottle, with SK1200E ultrasonic cleaner ultrasound 30min, external residual of the elution with adhesive tape avulsion out
Lotion obtains a series of samples to be measured, measures absorbance value of the sample liquid at 326nm.
Test result: as shown in Figure 9, the active matter of same concentrations is within the identical testing time, the external residual of P18-1
Concentration is higher, i.e., less by the skin care ingredient of percutaneous absorption；As shown in Figure 10, in the identical testing time, P18-2-3's is external
Residual volume percentage ratio P18-1 is small, illustrates in the same testing time, and the absorption rate of P18-2-3 is larger, and from figure
In as can be seen that 1h to 1.5h during P18-2-3 residual quantity percentage decline amount ratio P18-1 it is more, illustrate this section survey
It tries in the time, the absorption rate ratio P18-1's of P18-2-3 is big.
The anti-ageing submicron emulsion of 3 vitamin A of embodiment
The low viscous submicron emulsion formula table of 7 embodiment of table, 3 vitamin A
| Standard Chinese name | Mass percentage % |
| Water (purified water or deionized water) | 81.65 |
| EDETATE SODIUM (chelating agent in water soluble ingredient) | 0.05 |
| Butanediol (water soluble ingredient) | 8 |
| Retinol Palmitate (oil-soluble active UV absorption indicator substance) | 1 |
| Castor oil (moisturizing grease) | 3 |
| Castor-oil plant (Ricinus Communis) seed oil (moisturizing grease) | 5 |
| Solubilizer LRI (surfactant) | 1 |
| Methyl hydroxybenzoate (preservative) | 0.3 |
Note: the INCI title of solubilizer LRI: Cremophor RH40/- 26/ water of PPG-26- butylol polyether
The anti-ageing submicron emulsion of vitamin A the preparation method is as follows:
1. a suitable vessel is added in 1,3-BDO, EDETATE SODIUM and water, it is heated to 80-85 DEG C, is dissolved by heating completely,
It stirs evenly, is labeled as water phase, keep the temperature spare.
2. a suitable vessel is added in castor oil, Retinol Palmitate and solubilizer LRI, it is heated to 80-85 DEG C, is added
Thermal agitation is uniform, is labeled as oily phase, keeps the temperature spare.
3. under appropriate shearing condition, during the oil phase is added to the aqueous phase, stirs emulsifying 10 minutes, stop homogeneous, stirring
It is cooling.
4. be cooled to 40 DEG C hereinafter, allotment terminate, finally successively add methyl hydroxybenzoate again, obtain common homogeneous lotion；It takes
A part is labeled as ordinary emulsion P18-1 out, uses for contrast test.
5. use extra-high-pressure nano homogenizer, set temperature that cooling water starts the cycle over as 20 DEG C, setting host condition: height
Press pump: 1500bar, low pressure automatic adjustment are as follows: 32/33bar cleans extra-high-pressure nano homogenizer with purified water, then will be above-mentioned
The resulting ordinary emulsion of step pours into, and beginning is high-pressure homogeneous, and homogeneous resulting lotion early period is outwelled, and a clean container is taken to hold institute
The lotion obtained.The step repeats repeatedly, and submicron emulsion is made.
The effect assessment and performance detection of embodiment 3
1. centrifugation test
Equipment: instrument title: DTL-A- type desk centrifuge, centrifugation rate and length of testing speech: 2000rpm, 30min are surveyed
Test result: ordinary emulsion and submicron emulsion pass through centrifugation test, and the two is all stable emulsion.
2. partial size is tested
Equipment: Bettersize2000B laser fineness gage
Test result: as shown in figure 11, the partial size of ordinary emulsion is bigger more dispersed, processed through extra-high-pressure nano homogenizer
Lotion partial size it is smaller more concentrate, be distributed within the scope of submicron emulsion.
4 vitamin E of embodiment nourishes submicron emulsion
8 embodiment of table, 4 vitamin E nourishes submicron emulsion formula table
The anti-ageing submicron emulsion of vitamin A the preparation method is as follows:
1. first Sodium Hyaluronate, hexylene glycol, propylene glycol are added a suitable vessel and are dispersed with stirring uniformly, purifying is added
Water is heated to 80-85 DEG C, stirs evenly, and is labeled as water phase, keeps the temperature spare.
2. a suitable vessel is added in Sucrose acetoisobutyrate, tocopherol, Phenoxyethanol and solubilizer LRI, stirring is equal
It is even, it is heated to 80-85 DEG C, is labeled as oily phase, is kept the temperature spare.
3. the oil phase is added to the aqueous phase middle emulsifying 10 minutes in the case where stirring homogeneous, stop homogeneous, stirring cooling.
4. being cooled to 40 DEG C hereinafter, allotment terminates, taking-up a part is labeled as ordinary emulsion, uses for contrast test.
5. use extra-high-pressure nano homogenizer, set temperature that cooling water starts the cycle over as 20 DEG C, setting host condition: height
Press pump: 1500bar (can beat) in operation between 1460~1536, low pressure automatic adjustment are as follows: 32/33bar is cleaned with purified water
Then extra-high-pressure nano homogenizer is poured into the resulting ordinary emulsion of above-mentioned steps, beginning is high-pressure homogeneous, and homogeneous is resulting early period
Lotion is outwelled, and a clean container is taken to hold resulting lotion.The step is repeated two more times, and submicron emulsion is made.
The effect assessment and performance detection of embodiment 3-4
1. centrifugation test
Equipment: instrument title: DTL-A- type desk centrifuge, centrifugation rate and length of testing speech: 2000rpm, 30min are surveyed
Test result: ordinary emulsion and submicron emulsion pass through centrifugation test, and the two is all stable emulsion.
2. partial size is tested
Equipment: Bettersize2000B laser fineness gage
Test result: as shown in figure 12, the partial size of ordinary emulsion is bigger more dispersed, processed through extra-high-pressure nano homogenizer
Lotion partial size it is smaller more concentrate, be distributed within the scope of submicron emulsion.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of low viscous submicron emulsion, which is characterized in that by the raw material of following mass percentage through super-pressure nanometer homogeneous system
At:
The sum of mass percent of said components is 100%.
2. low viscous submicron emulsion as described in claim 1, which is characterized in that the water soluble ingredient is selected from chelating agent, single
Or the composition of one or more of polyols blend, water-soluble actives arbitrary proportion mixing.
3. low viscous submicron emulsion as described in claim 1, which is characterized in that the moisturizing grease is selected from Sucrose Acetate acid sucrose
Ester, castor bean, Castor oil, jojoba seed oil, olive oil, Queensland nut seed oil, olive oil, saualane, avocado oil, Portugal
Grape seed oil, sunflower oil, dog rose fruit oil, lavender oil, Prunus Amygdalus Dulcis Oil, oat kernel oil, thorn A Ganshu benevolence oil, pomegranate seed
The composition of one or more of oil, azadirachta seed oil, white pond flower seed oil arbitrary proportion mixing.
4. low viscous submicron emulsion as described in claim 1, which is characterized in that the oil-soluble active UV absorption indicator substance
One in vitamin A derivatives, tocopherol, tocopherol acetate, vitamine C palmitate, ascorbyl palmitate
Kind or the composition of two or more arbitrary proportions mixing.
5. low viscous submicron emulsion as described in claim 1, which is characterized in that the surfactant is selected from rilanit special
40, one or more of rilanit special 60, PPG-26- butylol polyether -26, solubilizer LRI arbitrary proportion mix
Composition.
6. low viscous submicron emulsion as described in claim 1, which is characterized in that the preservative is selected from methyl hydroxybenzoate, benzene oxygen second
One or more of alcohol, Sensiva SC50, benzyl alcohol, pentanediol, hexylene glycol, pungent glycol, olein are any
The composition of ratio mixing.
7. a kind of preparation method of low viscous submicron emulsion, which comprises the steps of:
1) water and water soluble ingredient of formula ratio under room temperature, is added, is dispersed with stirring and dissolves, forms system A；
2) moisturizing grease, oil-soluble active UV absorption indicator substance and the surfactant of formula ratio under room temperature, are added,
It stirs evenly, forms system B；
3) system B is added in system A room temperature, stirs homogeneous, and emulsification is uniform；Or system A, B is separately heated to 75~80
DEG C, homogeneous is stirred, uniformly, it is stand-by that room temperature is down in stirring for emulsification；The preservative for finally successively adding formula ratio again obtains common equal
Matter lotion；
4) it uses extra-high-pressure nano homogenizer emulsifying: setting the condition of extra-high-pressure nano homogenizer, it is equal with super-pressure nanometer
Matter machine carries out homogeneous to common homogeneous lotion obtained by step 3), to prepare low viscous submicron emulsion.
8. preparation method as claimed in claim 7, which is characterized in that the condition of the step 4) extra-high-pressure nano homogenizer is
The temperature of cooling water circulation is 20 DEG C；Set host high-pressure pump: 1500bar, low pressure automatic adjustment are as follows: 32/33bar.
9. preparation method as claimed in claim 7, which is characterized in that repeated homogeneous 2-9 times using the step 4).
10. a kind of low viscous submicron emulsion Transdermal absorption in skin care item, cosmetics as described in any one of claims 1-9
Using.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910349925.XA CN110215415A (en) | 2019-04-28 | 2019-04-28 | Low viscous submicron emulsion of one kind and the preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910349925.XA CN110215415A (en) | 2019-04-28 | 2019-04-28 | Low viscous submicron emulsion of one kind and the preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110215415A true CN110215415A (en) | 2019-09-10 |
Family
ID=67820154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910349925.XA Pending CN110215415A (en) | 2019-04-28 | 2019-04-28 | Low viscous submicron emulsion of one kind and the preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110215415A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111166682A (en) * | 2020-01-17 | 2020-05-19 | 广州娇兰佳人化妆品连锁有限公司 | Micro-emulsified skin care emulsion and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044343A1 (en) * | 1999-01-30 | 2000-08-03 | Henkel Kommanditgesellschaft Auf Aktien | Microemulsions and their use in finishing absorbent carrier substrates |
| CN108498382A (en) * | 2018-06-28 | 2018-09-07 | 武汉百思凯瑞生物科技有限公司 | A kind of moisturizing conveys nano-composition and its preparation method and application altogether |
| CN109453043A (en) * | 2018-12-13 | 2019-03-12 | 诺斯贝尔化妆品股份有限公司 | A kind of nanoemulsions having good stability |
| CN109568178A (en) * | 2017-09-29 | 2019-04-05 | 山西远扬医药科技有限公司 | A kind of nanometer of micro emulsion composition and its nano micro-emulsification cosmetic of preparation |
-
2019
- 2019-04-28 CN CN201910349925.XA patent/CN110215415A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044343A1 (en) * | 1999-01-30 | 2000-08-03 | Henkel Kommanditgesellschaft Auf Aktien | Microemulsions and their use in finishing absorbent carrier substrates |
| CN109568178A (en) * | 2017-09-29 | 2019-04-05 | 山西远扬医药科技有限公司 | A kind of nanometer of micro emulsion composition and its nano micro-emulsification cosmetic of preparation |
| CN108498382A (en) * | 2018-06-28 | 2018-09-07 | 武汉百思凯瑞生物科技有限公司 | A kind of moisturizing conveys nano-composition and its preparation method and application altogether |
| CN109453043A (en) * | 2018-12-13 | 2019-03-12 | 诺斯贝尔化妆品股份有限公司 | A kind of nanoemulsions having good stability |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111166682A (en) * | 2020-01-17 | 2020-05-19 | 广州娇兰佳人化妆品连锁有限公司 | Micro-emulsified skin care emulsion and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107397714B (en) | Have effects that anti-blue light contamination and desalinates essence cream and its preparation and application of microgroove | |
| CN107951771A (en) | A kind of baby child releives moisturizing skin care creams and preparation method thereof | |
| Hanifah et al. | Formulation and stability testing of nanoemulsion lotion containing centella asiatica extract | |
| Sahle et al. | Polyglycerol fatty acid ester surfactant–based microemulsions for targeted delivery of ceramide AP into the stratum corneum: Formulation, characterisation, in vitro release and penetration investigation | |
| CN109908004B (en) | Multiple emulsion sunscreen cosmetic and preparation method thereof | |
| CN112237556B (en) | Grease composition for repairing skin barrier and application thereof | |
| CN114617785B (en) | Vesicle type carrier and preparation method thereof, cosmetic auxiliary material and preparation method thereof | |
| CN105662896A (en) | Calophyllum inophyllum kernel oil included lecithin liposome and application thereof in soothing scar-fading products | |
| CN110063901A (en) | A kind of sun-proof creams and preparation method thereof suitable for sensitive flesh | |
| CN109846776A (en) | A kind of centella asiatica extract and its preparation method and application | |
| CN112137906A (en) | Composition for improving sun protection value of sun-proof emulsion and preparation method thereof | |
| CN110215415A (en) | Low viscous submicron emulsion of one kind and the preparation method and application thereof | |
| CN108434046A (en) | A kind of moisture-keeping cosmetics composition and moisturiser | |
| CN113332182A (en) | High-stability vegetable oil liposome and preparation and detection methods thereof | |
| CN108113924A (en) | A kind of composite plant Shu Min agent and preparation method and application | |
| CN107693418A (en) | One kind nourishes anti-chap camellia oleifera fruit hand lotion and preparation method thereof | |
| CN115154347B (en) | Cleansing cream and preparation method thereof | |
| CN116392403A (en) | Sun-screening composition, oil-in-water sun-screening emulsion preparation, and preparation method and application thereof | |
| CN115813807A (en) | Makeup removing cream and preparation method thereof | |
| CN115282106A (en) | Sunscreen emulsion containing fructus Phyllanthi extract and its preparation method | |
| CN108721151A (en) | A kind of makeup remover and preparation method thereof being prepared by trichosanthes seed oil | |
| Ishak et al. | Optimization, Development, And Safety Evaluation Of Olive Oil Nanoemulsion For Topical Application: A Response Surface Methodology | |
| CN114366696A (en) | A nanometer emulsion of fructus Bruceae oil with antiaging effect, and its preparation method and application | |
| CN117731552A (en) | Mangiferin microcapsule and preparation method and application thereof | |
| Lubart et al. | A Novel Facial Cream Based on Skin Penetrable Hemp Oil Microparticles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190910 |