CN114366696A - A nanometer emulsion of fructus Bruceae oil with antiaging effect, and its preparation method and application - Google Patents
A nanometer emulsion of fructus Bruceae oil with antiaging effect, and its preparation method and application Download PDFInfo
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Abstract
The invention belongs to the field of cosmetics, and relates to a Bridgkin fruit oil nano emulsion (O/W type) with an anti-aging effect, and a preparation method and application thereof. The nano-emulsion comprises the following components in parts by weight: 0.01-20 parts of mazuki fruit oil, 0.5-40 parts of polyhydric alcohol and 0.5-20 parts of polyglycerol surfactant, wherein the polyglycerol surfactant is polyglycerol water-in-oil type nonionic surfactant. The nano emulsion is O/W type nano emulsion prepared by adopting a non-high pressure homogenization process, the process is simple and easy to operate, and the prepared nano emulsion is stable and small in particle size, so that the product is easier to absorb by skin; compared with the traditional nano emulsion, the nano emulsion disclosed by the invention is milder, has strong moisture retention property, can effectively remove free radicals, and has an excellent anti-aging effect.
Description
Technical Field
The invention belongs to the field of cosmetics, and relates to a Bridgkin fruit oil nano emulsion with an anti-aging effect, and a preparation method and application thereof.
Background
Most of the emulsions in the market are prepared by a conventional emulsification method, and the emulsion has larger particle size, generally larger than 1um, influences the absorption of skin on nutrients and hardly plays an effect. Chinese patent CN104739658A discloses a ceramide nano-emulsion and a preparation method thereof, but the ceramide nano-emulsion is prepared by using an emulsifying machine capable of implementing high shear force such as a high-pressure emulsifying machine, and refining emulsified particles of the emulsion through the high shear force, the process has low mass production efficiency and high production cost, and in addition, the treatment by the high shear force may also cause the denaturation of various functional raw materials.
In the existing cosmetics, PEG-20 methyl glucose sesquistearate, PEG-20 stearate, PEG-100 stearate and the like are generally used as PEG (polyethylene glycol) type emulsifiers, ceteareth 6, ceteareth 25 and the like are used as emulsifiers, the emulsifiers are EO (ethylene oxide) type emulsifiers, the conventional emulsifiers are high in addition amount and low in combination cost, and the conventional emulsifiers contain dioxane, so that the conventional emulsifiers are irritant to skin, easily cause skin allergy and have carcinogenic risk after being used for a long time.
Disclosure of Invention
In some embodiments, the present invention provides a nanoemulsion comprising the following components in parts by weight: 0.01-20 parts of mazuki fruit oil, 0.5-40 parts of polyhydric alcohol and 0.5-20 parts of polyglycerol surfactant, wherein the polyglycerol surfactant is polyglycerol water-in-oil type nonionic surfactant.
The Bridgkin fruit oil is also called maorezu fruit oil, and is extracted from fruit of palm genus plant maorezu tree in Amazon basin.
In some embodiments, the nanoemulsion comprises the following components in parts by weight: 0.01-15 parts of Daphnia lansium fruit oil, 2-40 parts of polyhydric alcohol and 0.5-15 parts of polyglycerol surfactant.
In some embodiments, the nanoemulsion comprises the following components in parts by weight: 0.1-10 parts of Daphnia lansium fruit oil, 6-40 parts of polyhydric alcohol and 0.5-10 parts of polyglycerol surfactant.
In some embodiments, the polyglycerol-based surfactant comprises at least one of polyglycerol-2 diisostearate, polyglycerol-2 isostearate, polyglycerol-3 diisostearate, polyglycerol-3 stearate, or polyglycerol-3 polyrnerolate.
In some embodiments, the polyol comprises at least one of glycerol, butylene glycol, propylene glycol, or dipropylene glycol.
In some embodiments, the nanoemulsion further comprises 0.01 to 2 parts by weight of a thickener.
In some embodiments, the nanoemulsion further comprises 0.05 to 1.5 parts by weight of a thickener.
In some embodiments, the nanoemulsion further comprises 0.05 to 1.0 parts by weight of a thickener.
In some embodiments, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, sodium polyacrylate, acrylic acid/C10-30 alkanol acrylate crosspolymer, or ammonium acryloyldimethyl taurate/VP copolymer.
In some embodiments, the nanoemulsion further comprises 0.5-30 parts by weight of an emollient.
In some embodiments, the nanoemulsion further comprises 0.5-25 parts by weight of an emollient.
In some embodiments, the nanoemulsion further comprises 0.5-20 parts by weight of an emollient.
In some embodiments, the emollient comprises at least one of polydimethylsiloxane, cyclopentadimethylsiloxane, caprylic/capric triglyceride, dioctyl carbonate, meadowfoam seed oil, or squalane.
In some embodiments, the nanoemulsion further comprises a pH adjuster.
In some embodiments, the nanoemulsion comprises 0.01 to 1.5 parts by weight of a pH adjuster.
In some embodiments, the nano agent comprises 0.01 to 1.2 parts by weight of a pH adjusting agent.
In some embodiments, the nano agent comprises 0.01 to 1 part by weight of a pH adjusting agent.
In some embodiments, the pH adjusting agent comprises at least one of arginine, aminomethyl propanol, tromethamine, sodium hydroxide, and potassium hydroxide.
In some embodiments, the nanoemulsion further comprises a preservative.
In some embodiments, the nanoemulsion comprises 0.01-2 parts by weight of a preservative.
In some embodiments, the nanoemulsion comprises 0.01 to 1.5 parts by weight of a preservative.
In some embodiments, the nanoemulsion comprises 0.03-1.0 parts by weight of a preservative.
In some embodiments, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
In some embodiments, the present invention provides a nanoemulsion comprising the following components in weight percent: 0.01-20% of mazuki fruit oil, 0.5-40% of polyhydric alcohol, 0.5-20% of polyglycerol surfactant, 0.01-2% of thickening agent, 0.5-30% of emollient and 100% of water; the polyglycerol surfactant is polyglycerol water-in-oil nonionic surfactant.
In some embodiments, the anti-aging bruise fruit oil nanoemulsion (O/W type, oil-in-water) provided by the invention is prepared by adopting a non-high-pressure homogenization process, the process is simple and easy to operate, and the prepared nanoemulsion is stable and small in particle size, so that the product is easier to absorb by skin.
In some embodiments, the nanoemulsions of the present invention are milder than conventional nanoemulsions.
In some embodiments, the anti-aging Bridgkin fruit oil nanoemulsion prepared by the invention has good stability and strong moisture retention, can effectively remove free radicals, and has excellent anti-aging effect.
In some embodiments, the nanoemulsion comprises the following components in weight percent: 0.01-15% of mazuki fruit oil, 2-40% of polyhydric alcohol, 0.5-15% of polyglycerol surfactant, 0.05-1.5% of thickening agent, 0.5-25% of emollient and 100% of water.
In some embodiments, the nanoemulsion comprises the following components in weight percent: 0.1-10% of mazuki fruit oil, 6-40% of polyhydric alcohol, 0.5-10% of polyglycerol surfactant, 0.05-1.0% of thickening agent, 0.5-20% of emollient and 100% of water.
In some embodiments, the nanoemulsion further comprises a pH adjuster.
In some embodiments, the pH adjusting agent is 0.01 to 1.5% by weight.
In some embodiments, the pH adjusting agent is 0.01 to 1% by weight.
In some embodiments, the nanoemulsion further comprises a preservative.
In some embodiments, the preservative is present in an amount of 0.01 to 2% by weight.
In some embodiments, the preservative is present in an amount of 0.01 to 1.5% by weight.
In some embodiments, the polyglycerol water-in-oil surfactant comprises at least one of polyglycerol-2 diisostearate, polyglycerol-2 isostearate, polyglycerol-3 diisostearate, polyglycerol-3 stearate, or polyglycerol-3 polyrnerolate.
In some embodiments, the polyol comprises at least one of glycerol, butylene glycol, propylene glycol, or dipropylene glycol.
In some embodiments, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, sodium polyacrylate, acrylic acid/C10-30 alkanol acrylate crosspolymer, or ammonium acryloyldimethyl taurate/VP copolymer.
In some embodiments, the emollient comprises at least one of polydimethylsiloxane, cyclopentadimethylsiloxane, caprylic/capric triglyceride, dioctyl carbonate, meadowfoam seed oil, or squalane.
In some embodiments, the pH adjusting agent comprises at least one of arginine, aminomethyl propanol, tromethamine, sodium hydroxide, and potassium hydroxide.
In some embodiments, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
In some embodiments, the nanoemulsion is an oil-in-water nanoemulsion.
In some embodiments, the nanoemulsion ranges from 10nm to 2000nm in particle size.
In some embodiments, the nanoemulsion ranges from 10nm to 1000nm in particle size.
In some embodiments, the nanoemulsion ranges from 100nm to 500nm in particle size.
In some embodiments, the present invention provides a use of the nanoemulsion in preparing an anti-aging cosmetic.
In some embodiments, the present invention provides a method of preparing the nanoemulsion, comprising the steps of: (1) mixing and stirring the polyhydric alcohol and the polyglycerol water-in-oil type nonionic surfactant uniformly; (2) adding the emollient dropwise while stirring until the emollient is completely added and stirring uniformly; (3) dropwise adding water while stirring until the water is completely added and uniformly stirring to obtain oil phase gel; (4) putting deionized water and a thickening agent into a reaction kettle, heating to 60-90 ℃, and stirring to obtain uniform liquid; (5) cooling to 30-60 ℃, and stirring for dissolving uniformly; (6) and (4) adding the oil phase solution obtained in the step (3), and stirring and dissolving uniformly to obtain the oil phase.
In some embodiments, the step (5) comprises cooling to 30-60 ℃, adding a pH regulator and a preservative, and stirring to dissolve uniformly.
In some embodiments, the method of preparing the nanoemulsion of the present invention comprises two steps:
(1) the first step of preparing an oleogel comprises the steps of: 1) mixing and stirring the polyhydric alcohol and the polyglycerol water-in-oil type nonionic surfactant uniformly; 2) adding the emollient dropwise while stirring until the emollient is completely added and stirring uniformly; 3) dropwise adding deionized water while stirring until the deionized water is completely added and uniformly stirring;
(2) the second step is to prepare the nano emulsion, which comprises the following steps: 1) putting deionized water and a thickening agent into a reaction kettle, heating and stirring to obtain uniform liquid; 2) cooling, adding a pH regulator and a preservative, and stirring and dissolving uniformly; 3) adding oleogel, stirring and dissolving uniformly.
In some embodiments, the method of preparing the nanoemulsion of the present invention comprises two steps:
(1) the first step of preparing an oleogel comprises the steps of: 1) mixing and stirring the polyhydric alcohol and the polyglycerol water-in-oil type nonionic surfactant uniformly; 2) adding the emollient dropwise while stirring until the emollient is completely added and stirring uniformly; 3) dropwise adding deionized water while stirring until the deionized water is completely added and uniformly stirring;
(2) the second step is to prepare the nano emulsion, which comprises the following steps: 1) putting deionized water and a thickening agent into a reaction kettle, heating to about 70-85 ℃ (but not limited thereto), and stirring to obtain uniform liquid; 2) cooling to about 20-60 deg.C (but not limited thereto), adding pH regulator and antiseptic, stirring and dissolving uniformly; 3) adding oleogel, stirring and dissolving uniformly.
Detailed Description
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.
The "Bridgy fruit oil" manufacturer source used in the following examples was Clariant; trade name: RF3810 Burti Oil Refined.
Examples 1-5 Bridgkin's oil nanoemulsion formulations with anti-aging properties and methods of making the same
1. The first step is as follows: oil gel:
TABLE 1 oil gel formulation Table
The preparation method comprises the following steps:
(1) mixing and stirring the polyhydric alcohol and the polyglycerol water-in-oil type nonionic surfactant uniformly;
(2) adding the emollient dropwise while stirring until the emollient is completely added and stirring uniformly;
(3) and dropwise adding deionized water while stirring until the deionized water is completely added and uniformly stirring.
2. The second step is that: nano-emulsion:
TABLE 2 nanoemulsion formulation table
The preparation method comprises the following steps:
(1) putting deionized water and a thickening agent into a reaction kettle, heating to about 85 ℃, and stirring to obtain uniform liquid;
(2) cooling to about 45 ℃, adding a pH regulator and a preservative, and stirring and dissolving uniformly;
(3) adding oleogel, stirring and dissolving uniformly.
The obtained liquid was observed to obtain an oil-in-water type nano emulsion.
Comparative example 1A formula of a common emulsion containing Bridgkin's fruit oil (water-in-oil type) and a method for preparing the same
Compared with the example 1, the formula of the comparative example 1 has the same components, and the preparation process is different. Polyglycerol type water-in-oil nonionic surfactant in the conventional process, the type of emulsion prepared was water-in-oil emulsion, while the emulsion prepared in example 1 was oil-in-water emulsion.
TABLE 3A formula of common emulsion containing Bridgy fruit oil (water in oil type)
The preparation method comprises the following steps:
(1) adding water, thickener and glycerol in oil-containing phase into water phase pot, heating to about 85 deg.C, and stirring to obtain uniform liquid;
(2) putting the residual oil-phase material and methyl hydroxybenzoate and ethyl hydroxybenzoate in the antiseptic into an oil phase pot, heating to about 85 deg.C, and stirring to obtain a uniform liquid;
(3) slowly pumping the raw materials of the water phase pot into the oil phase pot, and simultaneously starting stirring and homogenizing until complete emulsification;
(4) cooling to about 40 ℃, adding the pH regulator and the materials in the residual preservative phase, and stirring and dissolving uniformly.
Comparative examples 2-4A common emulsion formulation (oil in water type) containing Bridgkin's fruit oil and method of making
The polyglycerol water-in-oil nonionic surfactant in example 1 was replaced with an oil-in-water polyglycerol nonionic surfactant and an EO-containing emulsifier, and the types and contents of the remaining materials were not changed.
TABLE 4 common emulsion (oil in water) containing Bridgy fruit oil formula table
The preparation method comprises the following steps:
(1) adding water, thickener and glycerol in oil-containing phase into water phase pot, heating to about 85 deg.C, and stirring to obtain uniform liquid;
(2) putting the residual oil-phase material and methyl hydroxybenzoate and propyl hydroxybenzoate in the antiseptic into an oil phase pot, heating to about 85 deg.C, and stirring to obtain a uniform liquid;
(3) slowly pumping the raw materials in the oil phase pot into the water phase pot, and simultaneously starting stirring and homogenizing until complete emulsification;
(4) cooling to about 40 ℃, adding the pH regulator and the materials in the residual preservative phase, and stirring and dissolving uniformly.
Comparative example 5
Compared with the formulation of example 1, the glycerin content of composition 1 in the component of example 1 is changed to 5%, and other materials and preparation methods are unchanged.
Comparative example 6
The glycerin content of composition 1 in the example 1 ingredient was changed to 50% compared to the example 1 formulation, with the other materials and preparation methods unchanged.
Comparative example 7
Compared with the formulation of the example 1, the same amount of the polyglycerol water-in-oil type nonionic surfactant contained in the composition 2 in the formulation of the example 1 is replaced by the water-in-oil type surfactant sorbitan sesquioleate, and other materials and preparation methods are unchanged.
Test 1 average particle diameter
The average particle size was determined using a laser particle size analyzer.
Test 2 stability test
Cold resistance: the sample was placed in a low-temperature refrigerator at-10. + -. 1 ℃ and returned to room temperature, and the presence or absence of delamination was observed.
Heat resistance: the sample was placed in a thermostat at 45. + -. 1 ℃ and returned to room temperature, and the presence or absence of delamination was observed.
And (3) centrifugal test: taking a certain amount of sample, setting the centrifugal rotating speed to be 3000r/min, centrifuging for 30min, and observing whether layering exists.
Table 5 particle size and stability test results
| Sample (I) | Average particle diameter/nm | Centrifugation | Heat resistance at 45 DEG C | Cold resistance at-10 deg.C |
| Example 1 | 320.6 | Stabilization | Stabilization | Stabilization |
| Example 2 | 384.1 | Stabilization | Stabilization | Stabilization |
| Example 3 | 380.6 | Stabilization | Stabilization | Stabilization |
| Example 4 | 363.7 | Stabilization | Stabilization | Stabilization |
| Example 5 | 352.9 | Stabilization | Stabilization | Stabilization |
| Comparative example 1 | / | Layering | Demixing after 1 day | Demixing after 1 day |
| Comparative example 2 | 2276 | Layering | Demixing after 4 days | Stabilization |
| Comparative example 3 | 1820 | Stabilization | Stabilization | Stabilization |
| Comparative example 4 | 2682 | Stabilization | Demixing after 7 days | Stabilization |
| Comparative example 5 | 4370 | Layering | Layering | Layering |
| Comparative example 6 | 1150 | Layering | Demixing after 7 days | Stabilization |
| Comparative example 7 | 1064.7 | Stabilization | Demixing after 7 days | Stabilization |
Particle size and stability test results show that the particle sizes of the samples of examples 1-5 are less than 400nm and obviously less than those of comparative examples 1-7, the samples of examples 1-5 are stable in centrifugation, heat resistance and cold resistance tests, and the samples of comparative examples 1-2 and 4-7 are unstable due to the layering phenomenon in the centrifugation and heat resistance test processes.
It can be seen from example 1 and comparative example 1 that, in the case of the same material and different processes, the emulsion prepared in example 1 is of oil-in-water type, and the emulsion prepared in comparative example 1 is of water-in-oil type, which are not comparable to each other. As can be seen from the comparison between example 1 and comparative examples 2-4, under the condition of the same amount of emulsifier and the same amount of other materials, the particle size of the sample in example 1 is smaller, the nano level can be achieved, and the stability is good.
As can be seen from the comparison of example 1 with comparative examples 5 to 6, neither formulations having a polyol content below or above a certain range in the product formulation can achieve a nano-scale or well-stabilized product.
Test 3 Patch test
1. The test substance: inventive examples 1-5 nanoemulsions.
2. The test method comprises the following steps: a proper spot sticking tester is selected, a closed spot sticking test method is adopted, a tested object is placed in the spot sticking tester, a special adhesive tape is externally applied to the back of a tested object, the tested object is removed after being applied for 24 hours, skin reactions are observed for 0.5 hour, 24 hours and 48 hours after the tested object is removed, the results are recorded according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition), and the test results are shown in Table 6.
TABLE 6 test results of human skin patches
The results of the human skin patch test show that 0 of 30 subjects in examples 1-5 have adverse skin reactions, which indicates that examples 1-5 of the invention are safe and non-irritant.
Test 4 comparative test against free radicals
Comparative tests were carried out with the same amount of nano-emulsion of the fruit oil of Bridgman as the conventional emulsion, and both the formulations of example 1 and comparative example 3 contained 1.25% of the fruit oil of Bridgman.
The samples of example 1 and comparative example 3 were prepared as 1% sample solutions, respectively, and the following tests were performed.
Test 4.1 test for superoxide anion radical scavenging ability
Preheating 4.5mL of Tris-HCl buffer solution with the concentration of 0.05mol/LpH ═ 8.2 in a water bath kettle at 25 ℃ for 20min, adding 1mL of sample and 0.4mL of 25mmol/L pyrogallol solution, uniformly mixing, reacting in the water bath kettle at 25 ℃ for 5min, and adding 1.0mL of 8mol/L HCI to terminate the reaction. The absorbance was measured at 299nm using Tris-HCl buffer as reference, and the blank was replaced with 1mL of the sample in solvent.
Superoxide anion radical clearance (%) [1- (a2/a1) ] -100%;
where A1 is the absorbance value of the blank and A2 is the absorbance value of the sample.
Test 4.2 measurement of scavenging ability for hydroxyl radical
2mmol/LFeSO are added into a 25mL colorimetric tube in turn43mL，1mmol/LH2O23mL, shaking up, then adding 3mL of salicylic acid with the concentration of 6mmol/L, shaking up, heating in a water bath at 37 ℃ for 15min, taking out, measuring the absorbance, respectively adding the solution to be measured with a certain concentration, shaking up, continuing to heat in the water bath for 15min, taking out and measuring the absorbance, wherein the following formula is the clearance rate of the solution to be measured on hydroxyl free radicals (OH).
The clearance rate (%) of hydroxyl radical is [ A0- (AX-AX 0) ]/A0X 100%
Wherein A0 is the absorbance value of the blank control; AX is the absorbance value after adding a sample to remove free radicals; AX0 without addition of H202Background absorbance value of the solution.
TABLE 7 free radical scavenging Capacity test results
| Sample (I) | Superoxide anion scavenging ratio (%) | P-hydroxy radical clearance (%) |
| Example 1 | 88.36 | 84.52 |
| Comparative example 3 | 54.93 | 56.17 |
The free radical scavenging ability test result shows that the superoxide anion scavenging rate of the embodiment 1 of the invention is up to more than 85%, the hydroxyl free radical scavenging rate is up to more than 84%, and the hydroxyl free radical scavenging rate is far higher than that of the comparative example 3, which shows that the anti-aging Bridgkin fruit oil nano emulsion provided by the invention has obvious free radical scavenging ability and can effectively prevent skin aging. Compared with common emulsion, the nano emulsion can promote the absorption of nutrients.
Experiment 5 human trial evaluation test
The samples of example 1 and comparative example 3 were selected for human trial evaluation tests, the test method being as follows:
60 healthy volunteers aged 35-55 years, 40 females, 20 males were selected and randomly divided into 2 groups of 20 females, 10 males, and the test site could not use any product (cosmetics or external medicines and health products for internal use) other than the test sample. The samples of example 1 were used for the left face and the samples of comparative example 3 were used for the right face, and the changes of the left face and the right face were observed once in the morning and evening for 4 weeks. In the trial process, the volunteers need to evaluate the moisture retention of the face, wrinkle fading effect, skin firmness and mildness, wherein the highest score is 5, and the lowest score is 1. The test results are shown in table 8.
TABLE 8 human body test results
| Sample (I) | Moisture retention | Wrinkle-reducing effect | Degree of skin firmness | Degree of mildness |
| Example 1 | 4.28 | 4.63 | 4.47 | 4.68 |
| Comparative example 3 | 3.62 | 3.24 | 3.32 | 4.26 |
Human body trial test results show that the comparative example 3 is an oil-in-water emulsion as compared with the example 1, is stable as the example 1, but has the advantages of humidity preservation, wrinkle reduction effect, skin firmness and mildness which are not as excellent as those of the example 1, and the Bridgkin fruit oil nano emulsion with the anti-aging function has good effects of humidity preservation and anti-aging.
Claims (10)
1. The nano-emulsion is characterized by comprising the following components in parts by weight: 0.01-20 parts of mazuki fruit oil, 0.5-40 parts of polyhydric alcohol and 0.5-20 parts of polyglycerol surfactant, wherein the polyglycerol surfactant is polyglycerol water-in-oil type nonionic surfactant.
2. The nanoemulsion of claim 1, comprising the following components in parts by weight: 0.01-15 parts of Daphnia lansium fruit oil, 2-40 parts of polyhydric alcohol and 0.5-15 parts of polyglycerol surfactant;
preferably, the composition comprises the following components in parts by weight: 0.1-10 parts of Daphnia lansium fruit oil, 6-40 parts of polyhydric alcohol and 0.5-10 parts of polyglycerol surfactant;
preferably, the polyglycerol-based surfactant comprises at least one of polyglycerol-2 diisostearate, polyglycerol-2 isostearate, polyglycerol-3 diisostearate, polyglycerol-3 stearate or polyglycerol-3 polyrnerolate; preferably, the polyol comprises glycerol, at least one of butylene glycol, propylene glycol or dipropylene glycol.
3. The nanoemulsion of claim 1, further comprising 0.01-2 parts by weight of a thickener;
preferably, 0.05 to 1.5 parts by weight of a thickening agent is contained;
preferably, 0.05 to 1.0 part by weight of a thickening agent is contained;
preferably, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, sodium polyacrylate, acrylic acid/C10-30 alkanol acrylate crosspolymer or ammonium acryloyldimethyl taurate/VP copolymer;
preferably, the nano-emulsion further comprises 0.5-30 parts by weight of an emollient;
preferably, the skin-care lotion comprises 0.5-25 parts by weight of an emollient;
preferably, the skin-care lotion comprises 0.5-20 parts by weight of an emollient;
preferably, the emollient comprises at least one of polydimethylsiloxane, cyclopentadimethylsiloxane, caprylic/capric triglyceride, dioctyl carbonate, meadowfoam seed oil, or squalane;
preferably, the nanoemulsion further comprises a pH adjuster;
preferably, the pH regulator comprises 0.01-1.5 parts by weight of pH regulator;
preferably, the pH regulator comprises 0.01-1.2 parts by weight of pH regulator;
preferably, the pH regulator comprises 0.01-1 part by weight of pH regulator;
preferably, the pH adjusting agent comprises at least one of arginine, aminomethyl propanol, tromethamine, sodium hydroxide and potassium hydroxide;
preferably, the nanoemulsion further comprises a preservative;
preferably, 0.01 to 2 parts by weight of a preservative is contained;
preferably, 0.01 to 1.5 parts by weight of a preservative is contained;
preferably, 0.03-1.0 part by weight of preservative is contained;
preferably, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
4. The nano-emulsion is characterized by comprising the following components in percentage by weight: 0.01-20% of mazuki fruit oil, 0.5-40% of polyhydric alcohol, 0.5-20% of polyglycerol surfactant, 0.01-2% of thickening agent, 0.5-30% of emollient and 100% of water; the polyglycerol surfactant is polyglycerol water-in-oil nonionic surfactant;
preferably, the nanoemulsion comprises the following components in percentage by weight: 0.01-15% of mazuki fruit oil, 2-40% of polyhydric alcohol, 0.5-15% of polyglycerol surfactant, 0.05-1.5% of thickening agent, 0.5-25% of emollient and 100% of water;
preferably, the nanoemulsion comprises the following components in percentage by weight: 0.1-10% of mazuki fruit oil, 6-40% of polyhydric alcohol, 0.5-10% of polyglycerol surfactant, 0.05-1.0% of thickening agent, 0.5-20% of emollient and 100% of water;
5. the nanoemulsion of claim 4, further comprising a pH adjuster;
preferably, the weight percentage of the pH regulator is 0.01-1.5%;
preferably, the weight percentage of the pH regulator is 0.01-1%;
preferably, the nanoemulsion further comprises a preservative;
preferably, the weight percentage of the preservative is 0.01-2%;
preferably, the weight percentage of the preservative is 0.01-1.5%.
6. The nanoemulsion of claim 4, wherein the polyglycerol-based surfactant comprises at least one of polyglycerol-2 diisostearate, polyglycerol-2 isostearate, polyglycerol-3 diisostearate, polyglycerol-3 stearate, or polyglycerol-3 polyrnerolate.
7. The nanoemulsion of claim 4, wherein the polyol comprises at least one of glycerol, butylene glycol, propylene glycol, or dipropylene glycol;
preferably, the thickener comprises at least one of xanthan gum, hydroxyethyl cellulose, carbomer, sodium polyacrylate, acrylic acid/C10-30 alkanol acrylate crosspolymer or ammonium acryloyldimethyl taurate/VP copolymer;
preferably, the emollient comprises at least one of polydimethylsiloxane, cyclopentadimethylsiloxane, caprylic/capric triglyceride, dioctyl carbonate, meadowfoam seed oil, or squalane;
preferably, the pH adjusting agent comprises at least one of arginine, aminomethyl propanol, tromethamine, sodium hydroxide and potassium hydroxide;
preferably, the preservative comprises at least one of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, sodium benzoate, or benzyl alcohol.
8. The nanoemulsion of any of claims 1-7, wherein the nanoemulsion is an oil-in-water nanoemulsion;
preferably, the particle size of the nano-emulsion is 10nm to 2000 nm;
preferably, the particle size of the nano-emulsion is 10 nm-1000 nm;
preferably, the particle size of the nano-emulsion is 100nm to 500 nm.
9. Use of a nanoemulsion as claimed in any one of claims 1 to 7 for the preparation of an anti-ageing cosmetic.
10. A process for preparing a nanoemulsion according to any of claims 1 to 7, comprising the following steps:
(1) mixing and stirring the polyhydric alcohol and the polyglycerol water-in-oil type nonionic surfactant uniformly;
(2) adding the emollient dropwise while stirring until the emollient is completely added and stirring uniformly;
(3) dropwise adding water while stirring until the water is completely added and uniformly stirring to obtain an oil phase solution;
(4) putting deionized water and a thickening agent into a reaction kettle, heating to 60-90 ℃, and stirring to obtain uniform liquid;
(5) cooling to 30-60 ℃, and stirring for dissolving uniformly;
(6) and (4) adding the oil phase solution obtained in the step (3), and stirring and dissolving uniformly to obtain the oil phase.
Preferably, the step (5) comprises cooling to 30-60 ℃, adding a pH regulator and a preservative, and stirring and dissolving uniformly;
preferably, the oil phase solution is an oil phase gel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210014866.2A CN114366696A (en) | 2022-01-07 | 2022-01-07 | A nanometer emulsion of fructus Bruceae oil with antiaging effect, and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210014866.2A CN114366696A (en) | 2022-01-07 | 2022-01-07 | A nanometer emulsion of fructus Bruceae oil with antiaging effect, and its preparation method and application |
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| JP2007070329A (en) * | 2005-09-09 | 2007-03-22 | Noevir Co Ltd | Microemulsion composition and method for producing the same |
| CN107693433A (en) * | 2017-11-13 | 2018-02-16 | 广州市花安堂生物科技有限公司 | A kind of moisturizing elite and preparation method thereof |
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| CN113876638A (en) * | 2021-10-18 | 2022-01-04 | 广州森馨生物科技有限公司 | High-stability skin-care moisturizing particle essence and preparation method thereof |
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2022
- 2022-01-07 CN CN202210014866.2A patent/CN114366696A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007070329A (en) * | 2005-09-09 | 2007-03-22 | Noevir Co Ltd | Microemulsion composition and method for producing the same |
| CN107693433A (en) * | 2017-11-13 | 2018-02-16 | 广州市花安堂生物科技有限公司 | A kind of moisturizing elite and preparation method thereof |
| CN112294701A (en) * | 2020-11-24 | 2021-02-02 | 泉后(广州)生物科技研究院有限公司 | Low-irritation whitening nano composition and preparation method and application thereof |
| CN113876638A (en) * | 2021-10-18 | 2022-01-04 | 广州森馨生物科技有限公司 | High-stability skin-care moisturizing particle essence and preparation method thereof |
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