CN109330914B - Nano ceramide emulsion and preparation process and application thereof - Google Patents
Nano ceramide emulsion and preparation process and application thereof Download PDFInfo
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- CN109330914B CN109330914B CN201811433085.7A CN201811433085A CN109330914B CN 109330914 B CN109330914 B CN 109330914B CN 201811433085 A CN201811433085 A CN 201811433085A CN 109330914 B CN109330914 B CN 109330914B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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Abstract
The invention provides a nano ceramide emulsion and a preparation process and application thereof, belonging to the technical field of cosmetics. 100 parts of the nano ceramide emulsion comprises 0.1-1 part of ceramide as a skin conditioner, 2-5 parts of isononyl isononanoate as an emollient oil, 0.5-2.0 parts of steareth-2 as an emulsifier, 0.5-2.0 parts of steareth-21 as an emulsifier, 0.1-0.5 part of vitamin E acetate as a skin conditioner and the balance of water. The nano ceramide emulsion product has the characteristics of stability, reliability, low irritation and good effect, and for the production process, the turning emulsification method is only related to the proportion of the emulsifier and the oil, so that no new equipment or special process is needed, and the nano ceramide emulsion product has strong advantages in production, thereby greatly reducing the production cost of the product and simultaneously ensuring the product effect.
Description
Technical Field
The invention relates to a nano ceramide emulsion and a preparation process thereof, belonging to the technical field of cosmetics.
Background
Ceramide is present as part of the skin composition in the stratum corneum in amounts up to 50%. With age, ceramide gradually runs off; experiments show that the cosmetic rich in ceramide can improve the hydration of skin, has the effects of resisting aging, supplementing intercellular substance, moisturizing and repairing, and is an extremely important raw material in high-grade cosmetics.
Under the circumstances, how to improve the utilization rate of ceramide becomes the subject of daily chemicals, wherein, the patent No. CN101707900A adopts a method of firstly preparing micro-emulsion and then preparing nano-emulsion by a high-pressure homogenizer, and the characteristic of easy penetration of the nano-emulsion is utilized to improve the utilization rate of the ceramide; also, the method of high pressure homogenization, which is the process method of patent No. CN106691889A, is used, and the method of improving the solubility in water after hydrolysis modification of ceramide is also used; for the process of firstly preparing the micron emulsion and then preparing the micron emulsion by using the high-pressure homogenizer, the process production is troublesome because emulsification is needed firstly and then high-pressure homogenization is needed, new equipment is also needed to be purchased, and the nano emulsion produced by the high-pressure homogenization has uneven particle size, emulsion liquid drops are easy to gather, so that the product becomes unstable, the productivity is low and the like, thereby limiting the application of the high-pressure homogenization method; in the modification method, the effect of the modified ceramide is difficult to confirm, and the effect of the modified ceramide cannot be ensured.
Disclosure of Invention
Based on the problems, the invention aims to provide a nano ceramide emulsion and a preparation process thereof, the nano ceramide emulsion is prepared by using a method of turning to an emulsification process, the particle size of the emulsion is distributed between 100 and 1000nm, the appearance of the nano ceramide emulsion has obvious light blue, and the turning to the emulsification process is only related to the emulsification process and the ratio of an emulsifier to oil, so that new equipment is not needed, and the nano ceramide emulsion has strong advantages in production.
In order to solve the technical problems, the invention adopts the following technical scheme:
a nano ceramide emulsion comprises the following components in parts by weight:
0.2-0.8 part of skin conditioner ceramide, 2-5 parts of skin-moistening grease isononyl isononanoate, 0.5-2.0 parts of emulsifier steareth-2, 0.5-2.0 parts of emulsifier steareth-21, 0.1-0.5 part of skin conditioner vitamin E acetate and the balance of water.
Furthermore, the nano ceramide emulsion also comprises 0.1-10 parts of humectant glycerin and 0.01-0.2 part of thickener xanthan gum.
In order to inhibit the growth of bacteria in the emulsion, 0.4-1.0 part of preservative is also added into the nano ceramide emulsion, wherein the preservative refers to raw materials which can be used for inhibiting the growth of bacteria in the cosmetic 2015 edition of cosmetic safety technical specification, and the preservative comprises but is not limited to sodium benzoate, potassium sorbate, phenoxyethanol and the like, and the addition amount of the preservative is added according to different types of the preservative; in addition, other water-soluble skin conditioning agents can be included to ensure better skin conditioning of the emulsion of the invention, and the water-soluble skin conditioning agents can be added according to actual conditions.
Further, the skin conditioner ceramide is at least one of a type I ceramide, a type II ceramide, and a type III ceramide.
A preparation process of nano ceramide emulsion comprises the following steps:
firstly, adding ceramide, isononyl isononanoate, vitamin E acetate, steareth-2 and steareth-21 into an emulsifying pot, stirring at the speed of 15-30rpm/min and heating to 80-90 ℃, simultaneously adding glycerol, xanthan gum and water into a water phase pot, and heating to 85-90 ℃; then pumping 20% of the water phase into an emulsifying pot, stirring for 10-20min under heat preservation, slowly cooling to 60 deg.C until the whole emulsion turns from milky white to transparent and then to light blue, adding the rest water phase and antiseptic, and cooling to room temperature to obtain the nanometer ceramide emulsion.
The nano ceramide emulsion can be applied to skin care cosmetics, including smoothing toner, eye cream, face cleaning cream, shower gel, hair dye, hair conditioner and the like.
Compared with the prior art, the invention has the following beneficial effects:
the nano ceramide emulsion product has the characteristics of stability, reliability, low irritation and good effect, and for the production process, the turning emulsification method is only related to the emulsification process and the proportion of the emulsifier and the oil, no new equipment is needed, and the nano ceramide emulsion product has strong advantages in production, so that the production cost of the product is greatly reduced, and the product effect can be ensured.
Detailed Description
In order that those skilled in the art will more clearly and intuitively understand the present invention, the present invention will be further described below.
Example 2
The nano ceramide emulsion comprises the following components in parts by weight per 100 parts of emulsion:
0.5 part of type II ceramide, 0.5 part of type III ceramide, 2 parts of skin moistening grease isononyl isononanoate, 1 part of emulsifier steareth-2, 1 part of emulsifier steareth-21, 0.1 part of skin conditioner vitamin E acetate, 10 parts of humectant glycerin, 0.1 part of xanthan gum, 0.6 part of phenoxyethanol and the balance of water.
Example 4
The nano ceramide emulsion comprises the following components in parts by weight per 100 parts of emulsion:
0.2 part of I-type ceramide, 0.1 part of II-type ceramide, 0.2 part of III-type ceramide, 4 parts of skin oil isononyl isononanoate, 2 parts of emulsifier steareth-2, 1 part of emulsifier steareth-21, 0.3 part of skin conditioner vitamin E acetate, 6 parts of humectant glycerin, 0.12 part of xanthan gum, 0.4 part of sodium benzoate and the balance of water.
Example 6
The nano ceramide emulsion comprises the following components in parts by weight per 100 parts of emulsion:
0.3 part of I-type ceramide, 0.3 part of II-type ceramide, 0.2 part of III-type ceramide, 4 parts of skin oil isononyl isononanoate, 1.8 parts of emulsifier steareth-2, 1.2 parts of emulsifier steareth-21, 0.5 part of skin conditioner vitamin E acetate, 4 parts of humectant glycerin, 0.15 part of xanthan gum, 0.8 part of phenoxyethanol and the balance of water.
The components and the amounts of the components added in the above examples are shown in Table 1. The same preparation process is adopted for manufacturing, and after the preparation is finished, the emulsion becomes blue-light-emitting and semitransparent, so that the nano-emulsion is finished, otherwise, the nano-emulsion fails. The preparation method comprises the following steps:
firstly, adding ceramide, isononyl isononanoate, vitamin E acetate, steareth-2 and steareth-21 into an emulsifying pot, stirring at the speed of 15-30rpm/min and heating to 80-90 ℃, simultaneously adding glycerol, xanthan gum, water and the like into a water phase pot, and heating to 85-90 ℃; then pumping 20% of the water phase into an emulsifying pot, stirring for 10-20min under heat preservation, slowly cooling to 60 deg.C until the whole emulsion turns from milky white to transparent and then to light blue, adding the rest water phase and antiseptic, and cooling to room temperature to obtain the nanometer ceramide emulsion.
Table 1 shows the components added in the examples and the amounts of the components added
For the above 3 examples, both examples 4, 6 gave blue-light-semipermeable emulsions, whereas example 2 gave only ordinary emulsions.
For the 2 successful ceramide nanoemulsions, stability testing and trial were performed, while 10 adult men and women were selected for safety and irritation testing, with the results shown in table 2.
Table 2 safety and irritation test results
| Name of test | Example 4 | Example 6 |
| Heat resistance of 48 DEG C | Stabilization | Stabilization |
| Cold resistance of minus 15 DEG C | Stabilization | Stabilization |
| Centrifugation | Stabilization | Stabilization |
| Has irritation feeling | 0 person | 0 person |
The test results show that the nano ceramide emulsion is stable and reliable, and has low irritation and good effect.
The embodiments described above are presented to enable those skilled in the art to make and use the invention. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the embodiments described herein, and those skilled in the art should make improvements and modifications to the present invention based on the disclosure of the present invention within the protection scope of the present invention.
Claims (6)
1. The nano ceramide emulsion is characterized in that 100 parts of emulsion comprises the following components in parts by weight:
0.2-0.8 part of skin conditioner ceramide, 2-5 parts of skin oil isononyl isononanoate, 0.5-2.0 parts of emulsifier steareth-2, 0.5-2.0 parts of emulsifier steareth-21, 0.1-0.5 part of skin conditioner vitamin E acetate and the balance of water;
the nano ceramide emulsion is prepared by a turning emulsion method.
2. The nano ceramide emulsion as claimed in claim 1, wherein 0.1-10 parts of glycerin as a humectant and 0.01-0.2 parts of xanthan gum as a thickener are further added.
3. The nano ceramide emulsion according to claim 2, wherein 0.4-1.0 part of preservative is further added.
4. The nano ceramide emulsion of claim 1, wherein the skin conditioning agent ceramide is at least one of a type I ceramide, a type II ceramide, and a type III ceramide.
5. A process for preparing the nano ceramide emulsion as claimed in claim 2 or 3, which comprises the following steps:
firstly, adding ceramide, isononyl isononanoate, vitamin E acetate, steareth-2 and steareth-21 into an emulsifying pot, stirring at the speed of 25rpm/min and heating to 90 ℃, simultaneously adding glycerol, xanthan gum and water into an aqueous phase pot, and heating to 90 ℃; then pumping 20% of the water phase into an emulsifying pot step by step, stirring for 20min under heat preservation, slowly cooling to 60 ℃ until the whole emulsion is changed from milky white to transparent and then to light blue, adding the rest water phase, and cooling to room temperature to obtain the nano ceramide emulsion.
6. Use of the nano ceramide emulsion according to any one of claims 1 to 4 in skin care cosmetics for non-therapeutic purposes.
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| CN114681351A (en) * | 2022-04-01 | 2022-07-01 | 广州市娇兰化妆品有限公司 | Nanoemulsion of ceramide-like extract with triple effects and preparation method and application thereof |
| CN114948756B (en) * | 2022-06-20 | 2023-05-23 | 华南理工大学 | Biomass high-concentration ceramide dispersion emulsion and preparation method thereof |
Citations (3)
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|---|---|---|---|---|
| CN1731986A (en) * | 2002-12-26 | 2006-02-08 | 考斯尼森斯公司 | Method for preparing PIT emulsion rubberized active fat soluble substance and emulsion prepared by the method |
| CN106963657A (en) * | 2017-02-17 | 2017-07-21 | 上海应用技术大学 | A kind of nanoemulsions and the method prepared using phase transition temperature method |
| CN108498382A (en) * | 2018-06-28 | 2018-09-07 | 武汉百思凯瑞生物科技有限公司 | A kind of moisturizing conveys nano-composition and its preparation method and application altogether |
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| CN103520080B (en) * | 2013-09-26 | 2015-10-28 | 广州市白云联佳精细化工厂 | The astringent of a kind of milky or micro-blueing light |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1731986A (en) * | 2002-12-26 | 2006-02-08 | 考斯尼森斯公司 | Method for preparing PIT emulsion rubberized active fat soluble substance and emulsion prepared by the method |
| CN106963657A (en) * | 2017-02-17 | 2017-07-21 | 上海应用技术大学 | A kind of nanoemulsions and the method prepared using phase transition temperature method |
| CN108498382A (en) * | 2018-06-28 | 2018-09-07 | 武汉百思凯瑞生物科技有限公司 | A kind of moisturizing conveys nano-composition and its preparation method and application altogether |
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