CN105534864A - Cosmetic composition having anti-allergic effect, preparation method and application thereof - Google Patents
Cosmetic composition having anti-allergic effect, preparation method and application thereof Download PDFInfo
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- CN105534864A CN105534864A CN201610037327.5A CN201610037327A CN105534864A CN 105534864 A CN105534864 A CN 105534864A CN 201610037327 A CN201610037327 A CN 201610037327A CN 105534864 A CN105534864 A CN 105534864A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/986—Milk; Derivatives thereof, e.g. butter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
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- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a cosmetic composition having an anti-allergic effect, in particular provides a cosmetic composition with an anti-allergic effect, which contains myrrh essential oil and goat milk. The composition can quickly permeate epidermis to reach the deep skin tissues, so as to play an unexpected anti-allergic role.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of to there is cosmetic composition of antiallergic effect and its preparation method and application.
Technical background
Common skin allergy is medically called allergy, also known as allergy, when referring to that body is subject to some antigenic stimulus, occurs based on the specific immune response of the exception of physiological dysfunction or tissue cell insult.Along with the continuous deterioration of global ecological environment, add the raising that people realize skin health, the perception rate of skin sensitivity and stimulation and attention rate rise gradually.According to incompletely statistics, the crowd that the whole world feels sensitivity skin gets more and more, and wherein male accounts for 38%, and women accounts for 61%.The developers of cosmetic industry appreciate this phenomenon, by Anti-allergic cosmetic pendulum in more and more important position.
Anti-allergic skin care product in the market obtains antiallergic effect often through some plant extracts of interpolation, but due to the barrier function of skin, the effective ingredient of plant extraction liquid especially polymer substance, water-soluble substances is difficult to absorbing transmission from skin, and causes actual effect very micro-.But, after a large amount of research work carried out in above-mentioned Anti-allergic cosmetic field, applicant unexpectedly, be surprised to find, known specified plant quintessence oil itself and Goat Milk are with the ratio combination in the scope determined very much in the art, due to its significant potentiation and permeance property, the antiallergic effect that the antiallergic composition tool obtained has clear improvement, thus complete the present invention.
Summary of the invention
For above-mentioned prior art, the technical problem to be solved in the present invention is to provide a kind of antiallergic composition, and said composition can be good at being absorbed through skin surface, has good antiallergic effect.
In order to solve the problems of the technologies described above, the present invention is achieved through the following technical solutions:
A kind of Anti-allergic cosmetic compositions, described compositions forms primarily of the component of following weight parts: Myrrha quintessence oil 0.01 ~ 1 part, Goat Milk 0.1 ~ 10 part.
Wherein in some embodiments, described compositions forms primarily of the component of following weight parts: Myrrha quintessence oil 0.1 ~ 0.5 part, Goat Milk 1 ~ 5 part.
Wherein in some embodiments, described compositions also comprises the component of following weight parts: Flos Magnoliae quintessence oil 0.01 ~ 1 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01 ~ 1 part and Olibanum quintessence oil 0.01 ~ 1 part.
Another object of the present invention is to provide a kind of cosmetics with antiallergic effect, its component primarily of following weight percentage ratio forms: above-mentioned there is antiallergic effect cosmetic composition 0.11 ~ 11wt%, emulsifying agent 1 ~ 4wt%, vegetable oil 5 ~ 10wt%, PEG-4001 ~ 8wt%, HANSHENGJIAO 0.1 ~ 0.5wt%, antiseptic 0.2 ~ 0.5%, water surplus.
Wherein in some embodiments, the described cosmetics with antiallergic effect, its component primarily of following weight percentage ratio forms: above-mentioned there is antiallergic effect cosmetic composition 2 ~ 5wt%, emulsifying agent 2 ~ 3wt%, vegetable oil 6 ~ 8wt%, PEG-4003 ~ 5wt%, HANSHENGJIAO 0.2 ~ 0.3wt%, antiseptic 0.3 ~ 0.4%, water surplus.
In a preferred embodiment of the invention, described emulsifying agent is a kind of in hydrolecithin, lecithin, glyceryl stearate, PEG-100 stearate, sorbitan stearate, polysorbate-20, polysorbate-60, Polyoxyethylene Sorbitan Monooleate, ceteareth-25, ceteareth-6, methyl sesquistearate, PEG-20 methyl sesquistearate, Pyrusussuriensis smooth olive oil acid esters, cetearyl glucoside, C12-20 alkyl androstanediol or their mixing.Preferred further, described emulsifying agent is hydrolecithin and C12-20 alkyl androstanediol.The weight of described hydrolecithin and C12-20 alkyl androstanediol is (1 ~ 2): (1 ~ 2).
In a preferred embodiment of the invention, described vegetable oil is a kind of in Oleum Hippophae, Ginger Root oil, soybean oil, safflower oil, olive oil, Radix Oenotherae erythrosepalae oil, Rosehips oil, American Avocado Tree oil, Jojoba oil, Oleum Vitis viniferae, white Limnanthes Alba Seed Oil, Butyrospermum parkii fruit fat, cocoa seed fat, macadimia nut seed oil, camellia seed oil, Petiolus Trachycarpi oil, palm-kernel oil, Rosa Canina fruit oil, Semen Tritici aestivi germ oil, Semen pruni armeniacae oil or their mixing.Preferred further, described vegetable oil is Jojoba oil and Oleum Vitis viniferae.The weight of described Jojoba oil and Oleum Vitis viniferae is (1 ~ 5): (1 ~ 5).
In a preferred embodiment of the invention, described antiseptic is described antiseptic can be pentanediol, hexanediol, glycerol caprylate, imidazolidinyl urea, DMDM Hydantoin, Methylisothiazolinone, phenoxyethanol, Nipagin ester apoplexy due to endogenous wind a kind of or their mixing.Preferred further, described antiseptic is Methylisothiazolinone, phenoxyethanol, and the mass ratio of described Methylisothiazolinone, phenoxyethanol is (0.005 ~ 0.01): (0.2 ~ 0.5).
Composite skin care product of the present invention can by the preparation of conventional production technology, preferred following preparation method, and it comprises the following steps:
(1) mentioned emulsifier, vegetable oil are dropped into oil phase pot, be heated to 70 ~ 85 DEG C, heat preservation for standby use after waiting all components to melt;
(2) above-mentioned PEG-400, HANSHENGJIAO, water are dropped into emulsifying pot, be heated to 70 ~ 85 DEG C, be incubated 15 ~ 30 minutes.
(3) by the emulsifying pot of the oil phase suction step (2) in step (1), homogenizing (homogenizing speed is 3000rpm) insulated and stirred (stir speed (S.S.) is 30rpm) 15 ~ 45 minutes after 3 ~ 15 minutes.
(4) under 102 ~ 108MPa pressure, 81 ~ 82 DEG C of temperature conditions, by high pressure homogenizer circulation homogenizing 8 ~ 9 times, control homogenizer outlet temperature lower than 85 DEG C, obtain the microemulsion of particle diameter at below 100nm.
(5) emulsion in step (4) is cooled to 40 ~ 45 DEG C, adds above-mentioned cosmetic composition, the preservative component with antiallergic effect, stir.
The preparation method of the microemulsion obtained by above-mentioned technique, have employed 2 homogenizing methods, common homogenizer is used for 1st time to obtain emulsified body, high pressure homogenizer is adopted for 2nd time to obtain microemulsion, obtained microemulsion particle diameter evenly, the stability of long-time placement is better, is more conducive to the osmotic absorption of product.Preparation process is simple and convenient, constant product quality, and large-scale industrial is produced convenient.
Beneficial effect of the present invention is as follows:
1, the present invention is through a large amount of experiment of inventor and research, and draw the compositions with antiallergic effect, it mainly comprises 2 kinds of components: Myrrha quintessence oil and Goat Milk.These 2 kinds of components are composite can reach deep skin tissue through epidermis rapidly, has beyond thought antiallergic effect.2, Flos Magnoliae quintessence oil Herba Lysimachiae foenum-graeci quintessence oil and Olibanum quintessence oil can the short ability of oozing of enhancing composition and antiallergic effects further.3, the raw material that antianaphylactic compositions of the present invention adopts is all natural origin, and it is safe and effective, also represent respect environment simultaneously, respects the new trend of consumer and Appropriate application natural resources.
Detailed description of the invention
Below in conjunction with detailed description of the invention to of the present invention for a more detailed description, but embodiments of the present invention are not limited thereto, and for the technological parameter do not indicated especially or condition, can refer to routine techniques and carry out.
Quintessence oil is from the flower of plant, leaf, stem, root or fruit, is refined the volatile flavor of extraction by steam distillation, squeezing and pressing method, cold-maceration or solvent extraction method.Flos Magnoliae quintessence oil in the present invention, Herba Lysimachiae foenum-graeci quintessence oil, Myrrha quintessence oil, Olibanum quintessence oil extract respectively and obtain from Flos Magnoliae, lavandula angustifolia, Myrrha, Olibanum.These quintessence oils can be commercially available respectively, also method conventionally can extract preparation voluntarily.Each quintessence oil in the present invention should meet the requirement of cosmetics related quality criterion.
Embodiment 1
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
Above-mentioned cosmetics can by the preparation of conventional production technology, preferred following preparation method, and it comprises the following steps:
(1) above-mentioned hydrolecithin, C12-20 alkyl androstanediol, Jojoba oil, Oleum Vitis viniferae are dropped into oil phase pot, be heated to 70 ~ 85 DEG C, heat preservation for standby use after waiting all components to melt;
(2) above-mentioned PEG-400, HANSHENGJIAO, water are dropped into emulsifying pot, be heated to 70 ~ 85 DEG C, be incubated 15 ~ 30 minutes.
(3) by the emulsifying pot of the oil phase suction step (2) in step (1), homogenizing (homogenizing speed is 3000rpm) insulated and stirred (stir speed (S.S.) is 30rpm) 15 ~ 45 minutes after 3 ~ 15 minutes.
(4) under 102 ~ 108MPa pressure, 81 ~ 82 DEG C of temperature conditions, by high pressure homogenizer circulation homogenizing 8 ~ 9 times, control homogenizer outlet temperature lower than 85 DEG C, obtain the microemulsion of particle diameter at below 100nm.
(5) emulsion in step (4) is cooled to 40 ~ 45 DEG C, adds above-mentioned Goat Milk, Myrrha quintessence oil, Methylisothiazolinone, phenoxyethanol, stir.
Embodiment 2
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
The preparation method of above-mentioned cosmetics is with embodiment 1.
Embodiment 3
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
The preparation method of above-mentioned cosmetics is with embodiment 1.
Embodiment 4
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
The preparation method of above-mentioned cosmetics is with embodiment 1.
Embodiment 5
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
The preparation method of above-mentioned cosmetics is with embodiment 1.
Embodiment 6
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
The preparation method of above-mentioned cosmetics is with embodiment 1.
Comparative example 1
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
The preparation method of above-mentioned cosmetics is with embodiment 1.
Comparative example 1
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
The preparation method of above-mentioned cosmetics is with embodiment 1.
Comparative example 3
A kind of compound with antiallergic effect of the present embodiment, it is made up of the raw material of following weight percentage ratio:
Above-mentioned cosmetics can by the preparation of conventional production technology, preferred following preparation method, and it comprises the following steps:
(1) above-mentioned hydrolecithin, C12-20 alkyl androstanediol, Jojoba oil, Oleum Vitis viniferae are dropped into oil phase pot, be heated to 70 ~ 85 DEG C, heat preservation for standby use after waiting all components to melt;
(2) above-mentioned PEG-400, HANSHENGJIAO, water are dropped into emulsifying pot, be heated to 70 ~ 85 DEG C, be incubated 15 ~ 30 minutes.
(3) by the emulsifying pot of the oil phase suction step (2) in step (1), homogenizing (homogenizing speed is 3000rpm) insulated and stirred (stir speed (S.S.) is 30rpm) 15 ~ 45 minutes after 3 ~ 15 minutes.
(4) emulsion in step (3) is cooled to 40 ~ 45 DEG C, adds above-mentioned Goat Milk, Myrrha quintessence oil, Methylisothiazolinone, phenoxyethanol, stir.
Experimental example 1 antiallergic efficacy assessments
One, experiment purpose
The antiallergic effect of the cosmetics obtained by the various embodiments described above is evaluated by relative analysis.
Two, experimental technique
Experiment grouping: this experiment is divided into experimental group and matched group, wherein the cosmetics of experimental group obtained by above-described embodiment 1 ~ 6, the cosmetics of matched group obtained by above-mentioned comparative example 1 ~ 3 and the commercially available Anti-allergic cosmetic of comparative example 4 one.
Tested object: above-mentioned each group all has volunteer 12,18-60 year, healthy, without dermatosis and irritated medical history, non-sensitive skin, can by Normalization rule cosmetics, and cooperating personnel complete appraisal on request, there is certain expressive faculty, the impression after energy actual response uses.
Testing scheme: using facial lip nasal fossa as test zone, smear the lactic acid of 10% at test zone, when tester feels stimulation, smears test products.Testee, according to pain, carries out when the 4th minute noting down antianaphylactic effect (dividing: without effect, slight effect, partial action and obvious effect).
Three, experimental result
Experimental result is in table 1.
Table 1 antiallergic table with test results
| Without effect | Slight effect | Partial action | Obvious effect | |
| Embodiment 1 | 0 | 1 | 6 | 5 |
| Embodiment 2 | 0 | 0 | 5 | 7 |
| Embodiment 3 | 0 | 0 | 4 | 8 |
| Embodiment 4 | 0 | 0 | 2 | 10 |
| Embodiment 5 | 0 | 0 | 3 | 9 |
| Embodiment 6 | 0 | 0 | 2 | 10 |
| Comparative example 1 | 2 | 3 | 4 | 3 |
| Comparative example 2 | 1 | 1 | 5 | 4 |
| Comparative example 3 | 0 | 2 | 4 | 6 |
| Comparative example 4 | 0 | 2 | 3 | 7 |
As known from Table 1, the Anti-allergic cosmetic obtained by embodiment 1 ~ 6 respond well, and be better than commercially available prod comparative example 4; Embodiment 3 is more known with embodiment 5 ~ 6, and Flos Magnoliae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil and Olibanum quintessence oil can strengthen the antiallergic effect of product further; Embodiment 3 is more known with comparative example 1 ~ 2, Myrrha quintessence oil and Goat Milk composite after there is collaborative antiallergic effect; Embodiment 3 is more known with comparative example 3, and the microemulsion system that 2 emulsion processes obtain can promote the antiallergic effect of product.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore all contents not departing from technical solution of the present invention, according to technical spirit of the present invention to any simple modification made for any of the above embodiments, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (8)
1. have the cosmetic composition of antiallergic effect, it is characterized in that, described compositions forms primarily of the component of following weight parts: Myrrha quintessence oil 0.01 ~ 1 part, Goat Milk 0.1 ~ 10 part.
2. the cosmetic composition with antiallergic effect according to claim 1, is characterized in that, described compositions forms primarily of the component of following weight parts: Myrrha quintessence oil 0.1 ~ 0.5 part, Goat Milk 1 ~ 5 part.
3. the cosmetic composition with antiallergic effect according to claim 1 and 2, is characterized in that, described compositions also comprises the component of following weight parts: Flos Magnoliae quintessence oil 0.01 ~ 1 part, Herba Lysimachiae foenum-graeci quintessence oil 0.01 ~ 1 part and Olibanum quintessence oil 0.01 ~ 1 part.
4. one kind has the cosmetics of antiallergic effect, it is characterized in that, described cosmetics form primarily of the component of following weight percentage ratio: the compositions 0.11 ~ 11wt% as described in any one of claim 1-3, emulsifying agent 1 ~ 4wt%, vegetable oil 5 ~ 10wt%, PEG-4001 ~ 8wt%, HANSHENGJIAO 0.1 ~ 0.5wt%, antiseptic 0.2 ~ 0.5%, water surplus.
5. cosmetics according to claim 4, it is characterized in that, described cosmetics form primarily of the component of following weight percentage ratio: the compositions 2 ~ 5wt% as described in any one of claim 1-3, emulsifying agent 2 ~ 3wt%, vegetable oil 6 ~ 8wt%, PEG-4003 ~ 5wt%, HANSHENGJIAO 0.2 ~ 0.3wt%, antiseptic 0.3 ~ 0.4%, water surplus.
6. the cosmetics according to claim 4 or 5, it is characterized in that, described emulsifying agent is a kind of in hydrolecithin, lecithin, glyceryl stearate, PEG-100 stearate, sorbitan stearate, polysorbate-20, polysorbate-60, Polyoxyethylene Sorbitan Monooleate, ceteareth-25, ceteareth-6, methyl sesquistearate, PEG-20 methyl sesquistearate, Pyrusussuriensis smooth olive oil acid esters, cetearyl glucoside, C12-20 alkyl androstanediol or their mixing.
7. the cosmetics according to claim 4 or 5, it is characterized in that, described vegetable oil is a kind of in Oleum Hippophae, Ginger Root oil, soybean oil, safflower oil, olive oil, Radix Oenotherae erythrosepalae oil, Rosehips oil, American Avocado Tree oil, Jojoba oil, Oleum Vitis viniferae, white Limnanthes Alba Seed Oil, Butyrospermum parkii fruit fat, cocoa seed fat, macadimia nut seed oil, camellia seed oil, Petiolus Trachycarpi oil, palm-kernel oil, Rosa Canina fruit oil, Semen Tritici aestivi germ oil, Semen pruni armeniacae oil or their mixing.
8. prepare a production method for the cosmetics as described in any one of claim 4 ~ 7, it is characterized in that, comprise the steps:
(1) emulsifying agent, vegetable oil are dropped into oil phase pot, be heated to 70 ~ 85 DEG C, heat preservation for standby use after waiting all components to melt;
(2) PEG-400, HANSHENGJIAO, water are dropped into emulsifying pot, be heated to 70 ~ 85 DEG C, stir, be incubated 15 ~ 30 minutes;
(3) by the emulsifying pot of the oil phase suction step (2) in step (1), homogenizing (homogenizing speed is 3000rpm) insulated and stirred (stir speed (S.S.) is 30rpm) 15 ~ 45 minutes after 3 ~ 15 minutes;
(4) under 102 ~ 108MPa pressure, 81 ~ 82 DEG C of temperature conditions, by high pressure homogenizer circulation homogenizing 8 ~ 9 times, control homogenizer outlet temperature lower than 85 DEG C, obtain the microemulsion of particle diameter at below 100nm;
(5) emulsion in step (4) is cooled to 40 ~ 45 DEG C, adds cosmetic composition, the antiseptic with antiallergic effect, stir.
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| CN114929034A (en) * | 2020-05-20 | 2022-08-19 | 株式会社索辛 | Antiallergic functional food composition, cosmetic, and transdermal preparation for external use |
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| CN114929034A (en) * | 2020-05-20 | 2022-08-19 | 株式会社索辛 | Antiallergic functional food composition, cosmetic, and transdermal preparation for external use |
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Application publication date: 20160504 |