CN103800219A - Multifunctional high-efficiency moisturizing stock solution - Google Patents
Multifunctional high-efficiency moisturizing stock solution Download PDFInfo
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- CN103800219A CN103800219A CN201210442325.6A CN201210442325A CN103800219A CN 103800219 A CN103800219 A CN 103800219A CN 201210442325 A CN201210442325 A CN 201210442325A CN 103800219 A CN103800219 A CN 103800219A
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Abstract
The invention provides a multifunctional high-efficiency moisturizing stock solution. The multifunctional high-efficiency moisturizing stock solution comprises polyglutamic acids with two molecular weight ranges or salts of the polyglutamic acids; wherein the average molecular weight of one polyglutamic acid ranges from 1000 to 10000Da, and the average molecular weight of the other polyglutamic acid ranges from 700000 to 1200000Da. The multifunctional high-efficiency moisturizing stock solution is capable of realizing intelligent moisture retention in environment with different temperature and humidity, forming a layer of moisturizing thin film on the surface of skin, reducing water loss, penetrating into skin corium layers, promoting generation of collagen, elastic fiber and self hyaluronic acid, slowing down skin aging, and refreshing skin. The multifunctional high-efficiency moisturizing stock solution is free of perfume, pigment, and mineral oil, and is especially suitable for people with allergic constitution and pregnant women. The multifunctional high-efficiency moisturizing stock solution can be used for preparation of a plurality of cosmetic products, and can be made into paste, cream, and emulsion.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of multi-functional efficient moisture-retention stock solution and exploration and application thereof.
Background technology
Healthy smooth skin comes from effective moisturizing, not only should have water absorbing capacity, and will have water holding capacity for the wetting agent material of skin care item, with the evaporation that prevents that water from dividing, and must have safety.The industrial traditional wetting agent that is applicable to make up comprises glycerol, sorbitol, sodium lactate, propylene glycol and aminoacid etc.Water absorbability, safety and the stability limit of these wetting agents its practical application effect.Although as glycerol, sorbitol and propylene glycol have good water retention property, easily cause the viscosity of skin care item to strengthen, skinfeel declines.Sodium lactate has good water holding capacity, in the formula of product, is difficult to emulsifying.Hyaluronic acid, collagen or amino-acid ester are with good water holding capacity, but its effect of evaporating from skin at minimizing water is lower and can manifest viscosity at skin surface.Although squalane has moisture retention and can avoid water to evaporate from skin surface, its oiliness character makes user dermal sensation greasy.In order to reach the moisture-retaining capacity of combination property, existing skin care item all use multiple wetting agent simultaneously.
With age, skin cell metabolism function declines gradually, and newborn collagen protein and hyaluronic acid decline, and the degradation process of mentioned component is accelerated simultaneously, causes xerosis cutis, flexibility decrease, and wrinkle increases.Due to environmental pollution and ultraviolet radiation, easily cause the colour of skin dimmed, lackluster, there is mottle in groups of people's face.For wrinkle and mottle, existing skin care item adopt chemicals more, and for example lactic acid contributes to dispel horny layer and enhances metabolism, and kojic acid has the effect of skin whitening.But the toxic and side effects of chemicals is large, zest is strong, and be difficult to reach the object for the treatment of both the principal and secondary aspects of a disease.Therefore, searching can be given smooth, the nonadherent multifunctional efficient moisturizer of skin care item skinfeel becomes skin care item industry problem demanding prompt solution.
The polyhydric molecular structure of polyglutamic acid and salt thereof, gives its excellent water binding property and moisture-retaining capacity, and its multiple skin-care effect is probed into and is applied in skin care item.Application patent (the JP 2004210700 A) report of ICHIMARU company of Japan, polyglutamic acid and salt thereof can impel the raising of Keratin (PCA), lactic acid (LA) and allantoin (UCA) equal size of skin nexine, thereby realize from inner its moisture-retaining capacity that strengthens of skin.Taiwan Wei Dan scientific & technical corporation entrusts the experiment of Duo Jia research institution to confirm, low-molecular-weight polyglutamic acid and salt thereof can stimulate fibroblast growth, and the polyglutamic acid of high molecular and salt thereof have effect that more obvious check melanin generates.And fibroblast participates in the process of the outer machine-processed composition secretion of various kinds of cell, comprise the Secretion regulation of collagen protein, Fibronectin, hyaluronic acid, chondroitin sulfate, dermatan sulfate and elastin laminin etc.Therefore, polyglutamic acid and salt thereof have also increased the generation of the natural moisture preservings such as skin self collagen albumen, hyaluronic acid and elastin laminin, the tender factor.
Different water suctions, moisturizing, whitening characteristic that the present invention utilizes the polyglutamic acid of different molecular weight to possess, a kind of economy and extremely effective Multifunctional protective moor liquid are provided, life-time service can also play gentle whitening effect, promote skin nature moisturizing factor to generate, reinvent healthy beautiful skin.This stock solution perfume-free, non-pigment, without mineral oil, be especially applicable to allergic constitution and anemia of pregnant woman and use.
Polyglutamic acid stock solution of the present invention not only can be used as moisture retention water and uses separately, also can be used as other skin care item formula mother solutions, plays skin care item synergistic function, soft and fine smooth feeling is provided and improves skin health.
Summary of the invention
The object of the invention is, for existing skin care item moisturizing composition viscosity, shortcoming that effect is single, provide a kind of multifunctional efficient moisturizing stock solution and exploration and application thereof with intelligent moisturizing, lock water, whitening, promotion skin health.
A kind of multifunctional efficient moisturizing stock solution, is characterized in that, concrete recipe ingredient is as follows:
Mean molecule quantity 10,00 ~ 10,000 daltonian polyglutamic acid or its salt 0.5% ~ 6%,
Mean molecule quantity 700,000 ~ 1200,000 daltonian polyglutamic acid or its salt 0.1% ~ 6%,
Hyaluronate sodium 0.01% ~ 3%,
Antiseptic 0.1% ~ 0.5%,
Sterilized water adds to 1000ml.
Preferably, in described component, polyglutamic acid or its salt are: polyglutamic acid sodium and/or polyglutamic acid potassium and/or polyglutamic acid magnesium and/or polyglutamic acid calcium.
Further preferred, in described component, polyglutamic acid or its salt are: polyglutamic acid sodium.
Preferably, in described component, polyglutamic acid or its salt particle mean size are: 10 ~ 150 μ m.
A kind of multifunctional efficient moisturizing stock solution, is characterized in that, concrete making step is as follows:
(1), by mean molecule quantity 10,00 ~ 10,000 daltonian polyglutamic acid or its salt are soluble in water, fully mix;
(2), by mean molecule quantity 700,000 ~ 1200,000 daltonian polyglutamic acid or its salt are soluble in water, fully mix;
(3) hyaluronate sodium is soluble in water, be heated to 60 ℃, fully dissolve and mix;
(4) by above-mentioned each composition mix homogeneously, add antiseptic stirring and dissolving, other compositions of polishing.
The present invention also provides the application of a kind of multifunctional efficient moisturizing stock solution aspect cosmetics making.
The application of above-mentioned multifunctional efficient moisturizing stock solution aspect cosmetics making, concrete steps are as follows:
(1) be averaged molecular weight 10,00 ~ 10,000 daltonian polyglutamic acid or its salt, mean molecule quantity 700,000 ~ 1200,000 daltonian polyglutamic acid or its salt, hyaluronate sodium, antiseptic and sterilized water, fully dissolve mix homogeneously, make a kind of multifunctional efficient moisturizing stock solution;
(2) the conventional adjuvant of preparing cosmetics is suitably added in sterilized water on demand, fully dissolve and mix;
(3) functional additive is added on demand in right amount without in water inlet, fully dissolve and mix;
(4) said components is pressed to the required proportioning mix homogeneously of different dosage form cosmetics, make unguentum, cream, emulsion etc.
Preferably, in described step (2), the conventional adjuvant of cosmetics comprises: as the oil phase component of solvent and emollient, as mineral oil, wax, higher alcohol, fatty acid, different monooctyl ester, lanoline, stearic acid etc.; Surfactant (anion, both sexes and nonionic), as hydroxy sulfo lycine, single laureth phosphate kalium salt, cocos nucifera oil both sexes sodium acetate, alkyl polyglucoside etc.; Water component, as water, glycerol, triethanolamine, potassium hydroxide etc.; Superfatting agent, as olein, emulsified silicone oil etc.; And antioxidant, chelating agen, antiseptic, spice etc.
Preferably, in described step (3), functional additive comprises: as vitamins, and amino acids, epidermal growth factor, plant extract etc.
Preferably, in described step (4), the adding proportion of multifunctional efficient moisturizing stock solution is 10% ~ 60%.
Preferably, in described step (4), the kind of cosmetics is: one of facial cream, emulsion, clean product, facial film, hair conditioner.
The specific embodiment
Below in conjunction with embodiment, the present invention is further elaborated, but institute of the present invention protection domain is not limited only to this.
1 one kinds of multi-functional efficient moisture-retention stock solutions of embodiment
(1) being averaged molecular weight is that 10,00 ~ 10,000 daltonian polyglutamic acid sodium powder 0.5kg is dissolved in sterilized water, fully mixes;
(2) being averaged molecular weight is that 700,000 ~ 1200,000 daltonian polyglutamic acid sodium powder 0.1kg is dissolved in sterilized water, fully mixes;
(3) get hyaluronate sodium 0.01kg soluble in water, be heated to 60 ℃, fully dissolve and mix;
(4) by above-mentioned each composition mix homogeneously, add antiseptic 0.1kg stirring and dissolving, add water to 100kg.
2 one kinds of multi-functional efficient moisture-retention stock solutions of embodiment
(1) being averaged molecular weight is that 10,00 ~ 10,000 daltonian polyglutamic acid sodium powder 1kg is dissolved in sterilized water, fully mixes;
(2) being averaged molecular weight is that 700,000 ~ 1200,000 daltonian polyglutamic acid sodium powder 0.5kg is dissolved in sterilized water, fully mixes;
(3) get hyaluronate sodium 0.05kg soluble in water, be heated to 60 ℃, fully dissolve and mix;
(4) by above-mentioned each composition mix homogeneously, add antiseptic 0.15kg stirring and dissolving, add water to 100kg.
The skin care cream that 3 one kinds of multi-functional efficient moisture-retention stock solutions of embodiment are made
Prescription:
Production technology: component A in component table is heated to 80 ℃, melts and stir; B component is heated to 80 ℃, dissolves and stirs.A phase solution adds in B phase solution and stirs, and after emulsifying evenly, while being cooled to 30 ℃, adds multi-functional efficient moisture-retention stock solution and spice, adjusts pH value to 7.0, stirs.
The whitening emulsion that 4 one kinds of multi-functional efficient moisture-retention stock solutions of embodiment are made
Prescription:
Production technology: component A in component table is heated to 80 ℃, melts and stir; B component is heated to 80 ℃, dissolves and stirs.A phase solution adds in B phase solution and stirs, and after emulsifying evenly, while being cooled to 30 ℃, adds multi-functional efficient moisture-retention stock solution and spice, adjusts pH value to 7.0, stirs.
Experimentation data of the present invention
1. the result of use of a kind of multi-functional efficient moisture-retention stock solution of the present invention
Experimental study: effect when investigation stock solution is used separately;
Select female volunteers 60 people;
Symptom before using: xerosis cutis, obscure tarnish, have wrinkle, mottle;
Using method: above-mentioned volunteer is divided into two groups at random: a group is used this multifunctional efficient moisturizing stock solution, and b group is used moisture retention water.Clean face, moisturizing stock solution or moisture retention water are applied to and are patted on the face until fully absorb, sooner or later respectively once, used one week every day;
The standard of curative effect evaluation:
(1) effective: skin beauty water is tender, fine and smooth, flexible, glossy, wrinkle and mottle reduce;
(2) invalid: skin wetness but obfuscation is matt, wrinkle and mottle have no obvious minimizing;
Effective percentage=effectively example/invalid example
Zest evaluation criterion:
A: volunteer is the imperceptible zest to skin all
B: the imperceptible zest of volunteer but have some senses of discomfort physically
C: one or several volunteer feel the zest to skin
Skinfeel evaluation criterion:
A: clean and tidy sense, smooth sense of touch
B: slightly toughness
C: significantly viscosity
Result (in table 1)
The comparative study of table 1 moisturizing stock solution result of use
| Assessment item | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example |
| Curative effect (effective percentage/%) | 96% | 93% | 95.0% | 66% |
| Zest | A | A | A | B |
| Skinfeel | A | A | B | C |
From result, due to efficient moisture-retention stock solution of the present invention and there is strong absorptive and effect of intelligent moisturizing, and form one deck moisturizing thin film at skin surface, reduce water loss, go deep into skin skin corium, slow down skin aging, newly-emerging, more common moisture retention water has better result of use.And moisturizing stock solution nonirritant of the present invention, has good skinfeel.
2. the result of use of the embodiment of the present invention 4
Experimental study: the result of use of investigating a kind of skin care cream of multi-functional efficient moisture-retention stock solution making
Select female volunteers 60 people;
Symptom before using: pachylosis, obscure tarnish, have wrinkle, mottle;
Using method: above-mentioned volunteer is divided into two groups at random: a group is used this skin care cream, and b group is used common facial cream.Clean face, facial cream is applied to and is patted on the face until fully absorb, sooner or later respectively once, used one week every day;
The standard of curative effect evaluation:
(1) effective: skin exquisiteness is tender, flexible, glossy, wrinkle and mottle reduce;
(2) invalid: xerosis cutis, obfuscation, tarnish, wrinkle and mottle have no obvious minimizing;
Effective percentage=effectively example/invalid example
Zest evaluation criterion:
A: volunteer is the imperceptible zest to skin all
B: the imperceptible zest of volunteer but have some senses of discomfort physically
C: one or several volunteer feel the zest to skin
Skinfeel evaluation criterion:
A: clean and tidy sense, smooth sense of touch
B: slightly toughness
C: significantly viscosity
Result (in table 2)
The comparative study of table 2 skin care cream result of use
| Assessment item | Embodiment 4 | Comparative example |
| Curative effect (effective percentage/%) | 96% | 66% |
| Zest | A | B |
| Skinfeel | A | C |
From result, the skin care cream of making due to efficient moisture-retention stock solution of the present invention not only can intelligent moisturizing, can also go deep into skin skin corium, promotes skin self collagen albumen, elastic fiber and hyaluronic acid to generate, thereby make skin newly-emerging, more common facial cream has better result of use.And skin care cream nonirritant of the present invention, has good skinfeel.
3. the result of use of the embodiment of the present invention 5
Experimental study: the result of use of investigating a kind of whitening emulsion of multi-functional efficient moisture-retention stock solution making;
Select female volunteers 60 people;
Symptom before using: more black, the obscure tarnish of skin, has mottle deposition;
Using method: above-mentioned volunteer is divided into two groups at random: a group is used this whitening emulsion, and b group is used common whitening emulsion.Clean face, emulsion is applied to and is patted on the face until fully absorb, sooner or later respectively once, used one week every day;
The standard of curative effect evaluation:
(1) effective: skin-whitening, water are tender, flexible, glossy, and mottle reduces;
(2) invalid: skin obfuscation, tarnish, mottle has no obvious minimizing;
Effective percentage=effectively example/invalid example
Zest evaluation criterion:
A: volunteer is the imperceptible zest to skin all
B: the imperceptible zest of volunteer but have some senses of discomfort physically
C: one or several volunteer feel the zest to skin
Skinfeel evaluation criterion:
A: clean and tidy sense, smooth sense of touch
B: slightly toughness
C: significantly viscosity
Result (in table 3)
The comparative study of table 3 whitening emulsion result of use
| Assessment item | Embodiment 5 | Comparative example |
| Curative effect (effective percentage/%) | 93% | 70% |
| Zest | A | C |
| Skinfeel | A | C |
From result, the whitening emulsion of making due to efficient moisture-retention stock solution of the present invention not only can intelligent moisturizing, can also go deep into skin skin corium, suppressing dermal melanin generates, and nonirritant, has good skinfeel, and more common whitening emulsion has better result of use.
Claims (6)
1. a multi-functional efficient moisture-retention stock solution, is characterized in that: the polyglutamic acid that comprises two kinds of different molecular weight ranges or its salt.
2. according to the multi-functional efficient moisture-retention stock solution of one claimed in claim 1, it is characterized in that: wherein the average molecular weight range of a kind of polyglutamic acid or its salt is 10,00 ~ 10,000 dalton, the average molecular weight range of another kind of polyglutamic acid or its salt is 700,000 ~ 1200,000 dalton.
3. according to the multi-functional efficient moisture-retention stock solution of one claimed in claim 1, it is characterized in that, concrete formula is as follows:
Mean molecule quantity 10,00 ~ 10,000 daltonian polyglutamic acid or its salt 0.5% ~ 6%,
Mean molecule quantity 700,000 ~ 1200,000 daltonian polyglutamic acid or its salt 0.1% ~ 6%,
Hyaluronate sodium 0.01% ~ 3%,
Antiseptic 0.1% ~ 0.5%,
Sterilized water adds to 1000ml.
4. the application in cosmetics are made according to a kind of multi-functional efficient moisture-retention stock solution claimed in claim 1.
5. according to application claimed in claim 4, it is characterized in that, concrete steps are as follows:
(1) be averaged the daltonian polyglutamic acid of molecular weight 10 00 ~ 10000 or its salt, mean molecule quantity 700,000 ~ 1200,000 daltonian polyglutamic acid or its salt, hyaluronate sodium, antiseptic and sterilized water, fully dissolve mix homogeneously, make a kind of multifunctional efficient moisturizing stock solution;
(2) the conventional adjuvant of preparing cosmetics is suitably added in sterilized water on demand, fully dissolve and mix;
(3) functional additive is added on demand in right amount without in water inlet, fully dissolve and mix;
(4) said components is pressed to the required proportioning mix homogeneously of different dosage form cosmetics, make unguentum, cream, emulsion etc.
6. application according to claim 4, is characterized in that, the kind of described cosmetics is: one of facial cream, emulsion, clean product, facial film, hair conditioner.
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| CN201210442325.6A CN103800219A (en) | 2012-11-08 | 2012-11-08 | Multifunctional high-efficiency moisturizing stock solution |
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| CN104800124A (en) * | 2015-04-28 | 2015-07-29 | 百朗德生物化学海门有限公司 | Cosmetic raw material composition for preventing skin aging and cosmetics containing same |
| CN105267234A (en) * | 2015-10-29 | 2016-01-27 | 山东省药学科学院 | Composition for relieving xerostomia and preparation method thereof |
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| CN106074262A (en) * | 2016-07-04 | 2016-11-09 | 郭传明 | Compositions containing Semen Castaneae and its preparation method and application |
| CN106265329A (en) * | 2016-09-07 | 2017-01-04 | 山东省药学科学院 | A kind of conditioner and application thereof |
| CN106344466A (en) * | 2016-11-22 | 2017-01-25 | 郑州兰茜生物工程有限公司 | Biological fermentation shampoo with effects of arresting alopecia and growing hairs and preparation method thereof |
| WO2018117550A1 (en) * | 2016-12-19 | 2018-06-28 | 주식회사 바이오리더스 | Composition for alleviating atopic skin symptoms, containing poly-gamma-glutamic acid |
| CN108685730A (en) * | 2018-07-10 | 2018-10-23 | 天津软银科技有限公司 | It is a kind of that there is antioxygen, reparation, crease-resistant, water supplement function solution and preparation method thereof |
| CN108703940A (en) * | 2018-08-20 | 2018-10-26 | 广州无添加主义化妆品有限公司 | A kind of water chestnut facial mask liquid and preparation method thereof, water chestnut facial mask |
| CN108852988A (en) * | 2018-07-28 | 2018-11-23 | 高昕文 | A kind of old age face nursing facial mask liquid |
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| CN110075006A (en) * | 2019-04-19 | 2019-08-02 | 华熙生物科技股份有限公司 | Promote the method for the solution compatibility of hyaluronic acid substance and typeⅡ Collagen and the composition containing both substances |
| CN111544643A (en) * | 2020-04-23 | 2020-08-18 | 海南芬森医疗器械有限公司 | Gamma-polyglutamic acid skin barrier repair dressing and preparation method thereof |
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| CN104800124B (en) * | 2015-04-28 | 2018-04-10 | 百朗德生物化学海门有限公司 | It is a kind of to prevent the cosmetic material composition of skin aging and the cosmetics containing the cosmetic material composition |
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| CN108852988A (en) * | 2018-07-28 | 2018-11-23 | 高昕文 | A kind of old age face nursing facial mask liquid |
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| CN111904894A (en) * | 2020-08-18 | 2020-11-10 | 山东华熙海御生物医药有限公司 | Application of ultra-high molecular weight gamma-PGA or salt thereof in cosmetics and cosmetic composition |
| CN111904894B (en) * | 2020-08-18 | 2023-07-28 | 华熙生物科技股份有限公司 | Application of ultra-high molecular weight gamma-PGA or salt thereof in cosmetics and cosmetic composition |
| CN112402322A (en) * | 2020-11-30 | 2021-02-26 | 黄丹 | Facial mask liquid capable of promoting expression of aquaporins AQP3 and AQP9 |
| WO2023168365A1 (en) * | 2022-03-02 | 2023-09-07 | Jds Therapeutics, Llc | Polyglutamic acid compositions and methods of using |
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