CN104800124A - Cosmetic raw material composition for preventing skin aging and cosmetics containing same - Google Patents
Cosmetic raw material composition for preventing skin aging and cosmetics containing same Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 230000009759 skin aging Effects 0.000 title claims abstract description 22
- 239000002994 raw material Substances 0.000 title claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 17
- 239000004220 glutamic acid Substances 0.000 claims abstract description 16
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 12
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Abstract
The invention discloses cosmetic raw material composition for preventing skin aging. The cosmetic raw material composition comprises brasenia schreberi extract, hyaluronic acid and poly gamma-glutamic acid, wherein the mass ratio of the brasenia schreberi extract to hyaluronic acid to poly gamma-glutamic acid is (2-5):(2-5):(2-5). The invention further discloses cosmetics containing 1-3% by mass of the cosmetic raw material composition. The cosmetic raw material composition has the advantages that the cosmetic raw material composition containing the brasenia schreberi extract, hyaluronic acid and poly gamma-glutamic acid has a comprehensive effect and has an excellent effect on skin aging and skin moistening, and the cosmetic raw material composition nearly does not have side effects on skin because the brasenia schreberi extract is extracted from a natural substance.
Description
Technical field
The present invention relates to cosmetics preparation field, specifically a kind of prevent skin aging cosmetic material compositions and cosmetics containing this cosmetic material compositions.
Background technology
The outmost horny layer of skin, has the function regulating moisture evaporation and absorb, and has opposing chemical substance, and the function of the exterior materials such as noxious substance and antibacterial invasion, serves the effect of skin barrier.With advancing age, the original function of skin is degenerated gradually, meanwhile occurs catabiosis, and wherein representational example forms wrinkle and melanin exactly.The free radical produced due to the ultraviolet of sunlight, promote the formation of the connective tissue-collagen protein of skin and the oxidisability tomography of elastic fiber, finally cause the abnormal cross coupled of connective tissue and create wrinkle, and promote the hyaluronic tomography and the low molecule quantification that keep playing in moisture ability most important functions at skin, be also the reason causing cuticular water holding capacity to reduce.
Hyaluronic acid is the mucopolysaccharide class being present in skin corium, and what have brilliance organizes curative effect and moistening effect, and it has the ability attracting to be equivalent to the moisture of own wt about 6000 times, so keep the ability of moisture remarkable especially.In order to slow down xerosis cutis and microgroove, will use containing hyaluronic beautifying face, preserving moisture agent.
Poly-γ glutamic acid refers to the aminoacid macromolecule being combined formed anionic property between the γ-carboxyl of glutamic acid and the α-amido of glutamic acid through amido link, the activity of collagen protein catabolic enzyme can be suppressed, remove cutin, form skin membrane, there is the effect increasing skin smoothness and moisturizing.
The blade back of Folium Braseniae Schreberi and petiole are covered with mucus, and in addition, in the water of leaf, petiole, branch stem, bud, part is also all covered with thick mucus, the vitamin C in its transparent colloid and serine, and energy delay skin aging, reduces wrinkle, have beauty functions concurrently.
The horny layer of skin containing have an appointment 20% moisture, moisture is the key factor determining skin elasticity and glossiness.If the moisture of skin is lower than 10%, so the physiological action of skin will reduce, and skin will lose original function, and causes skin to become coarse.In cosmetics, wetting agent is used to be necessary in order to prevent xerosis cutis.Therefore develop safe in the externally applied product of skin, result of use is outstanding and have the material of strong moistening effect, has become one of important topic in cosmetics research.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of prevent skin aging cosmetic material compositions and cosmetics containing this cosmetic material compositions, these cosmetics have the outstanding effect and the moistening effect that prevent skin aging.
The present invention takes following technical scheme: a kind of cosmetic material compositions preventing skin aging, comprises Folium Braseniae Schreberi extract, hyaluronic acid and poly-γ glutamic acid, and described Folium Braseniae Schreberi extract, the mass ratio of hyaluronic acid and poly-γ glutamic acid is 2 ~ 5: 2 ~ 5: 2 ~ 5.
Wherein, hyaluronic mean molecule quantity is 500,000 ~ 3,000,000 dalton, and the mean molecule quantity of poly-γ glutamic acid is 1,000,000 ~ 5,000,000 dalton.
The present invention also comprises a kind of cosmetics preventing skin aging, and the raw material composition of these cosmetics comprises above-mentioned cosmetic material compositions, and the mass percent of this cosmetic material compositions in the raw material composition of cosmetics is 1-3%.
These cosmetics are toner/smoothing toner, emulsion, nourishing cream, essence and foundation cream specifically.
Advantage of the present invention is: containing Folium Braseniae Schreberi extract, the cosmetic material compositions of hyaluronic acid and poly-γ glutamic acid mixture has resultant effect, to skin aging and skin moisture-keeping, there is remarkable effect, and derive from natural materials due to Folium Braseniae Schreberi extract, skin is almost free from side effects.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
The extraction of Folium Braseniae Schreberi crude extract: can ultrasonic extraction be used, reflux cooling extracts, heating extraction, the extracting method such as supercritical extraction, filter with 200-300 object filter cloth after extracting, obtain Folium Braseniae Schreberi extracting solution preferably by heating extraction, extracting solution after filtration is at 20-80 DEG C, most suitable is at 40-60 DEG C, carries out drying with rotating pressure-decreasing rapid steamer, can obtain the dried powder of Folium Braseniae Schreberi crude extract.Wherein Extraction solvent is water, charcoal element water, ethanol, propylene glycol, ethyl acetate, and butanediol, ether or chloroform, preferably 3 ~ 10 times of volume water are as Extraction solvent, extract 2-15 hours under the Extracting temperature of 40-95 DEG C.
The production of Folium Braseniae Schreberi macromolecule polysaccharide: put into 10kg ultra-pure water in dry Folium Braseniae Schreberi 1kg, heat at 80 DEG C and extract for 6 hours.With 250 object filter-cloth filterings, add 30kg ethanol and leave standstill and precipitate, by filtering and centrifugalize reclaim precipitation, obtain 17.4g containing Folium Braseniae Schreberi macromolecule polysaccharide.
Prevent the production of the cosmetic material compositions of skin aging:
The production of Folium Braseniae Schreberi crude extract: the ultra-pure water putting into 10kg in dry Folium Braseniae Schreberi 1kg, heats and extracts for 6 hours at 80 DEG C.With 250 object filter-cloth filterings, concentrating under reduced pressure at 60 DEG C, obtain the Folium Braseniae Schreberi crude extract of 35.7g.
Hyaluronic acid and poly-γ glutamic acid are for buying product.
Above-mentioned three kinds of materials mix according to the ratio (% by weight) in following table 1, are dissolved in ultra-pure water, have made the product of 100 μ g/ml.
Table 1, the cosmetic material compositions of different ratio and matched group.
Experimental example 1: in table 1, the anti-oxidation efficacy of the cosmetic material compositions of skin aging that prevents of various proportioning is tested.
One of anti-aging effect of each sample in table 1: the detection method of anti-oxidation efficacy is as follows: 1,1-diphenyl-2-trinitrophenyl-hydrazine (DPPH) can produce free radical in ethanol, it is mixed according to certain ratio with each sample in table 1 and matched group respectively, confirms the degree that the amount of the free radical generated reduces.In 0.2ml ethanol, be each sample solution 0.3ml of 100 μ g/ml by the ultimate density of ultra-pure water preparation in the 0.1mmol/L DPPH solution 0.5ml of interpolation alcohol solvent preparation and table 1.Then, after above-mentioned solution rotates 10 seconds strongly, leave standstill 30 minutes in the cool, measure absorbance with ELISA under 517nm, blank group uses 70% ethanol, and the result of the percentage ratio shown by the degree of anti-oxidation efficacy is as shown in table 2.
Table 2, the anti-oxidation efficacy test result of each sample and matched group.
Often organize sample test and repeat 3 times, to compare the anti-oxidation efficacy that can find each group of sample all fine with blank group.And compare discovery with matched group 3, for each sample, although ultimate density is very low, anti-oxidation efficacy is but very strong.Therefore, can be drawn by table 2 data, cosmetic material compositions of the present invention has fine antioxidant effect, than using independent material to have better anti-oxidation efficacy, has the effect preventing skin aging.
Experimental example 2: in table 1, the cosmetic material compositions of skin aging that prevents of various proportioning suppresses the mensuration of collagenase activity
In table 1, each sample is to the suppression level determinations of collagenase activity, measure according to methods such as Wunsch: in 0.15ml 0.1M Tris-HCl buffer (pH 7.5), add 4mM calcium chloride water 0.25ml, concentration is the 4-phenylazo benzyloxycarbonyl group-L-PRO-LEU-GLY-PRO-D-ARG culture medium aqueous solution 0.25ml and sample solution 0.1ml of 0.3 ㎎/ml, after mixing, add the collagen protein enzyme aqueous solution 0.15ml that concentration is 0.2 ㎎/ml wherein again, the citric acid 0.5ml that mass percent is 6% is put into after room temperature places 20 minutes, after stopped reaction, add ethyl acetate, determine the absorbance under 320nm.
In table 1, each sample and the suppression ratio of matched group to collagenase activity show with the interpolation of sample solution and the absorbance reduction rate that do not add Collagenase.Its result is as shown in table 3.
Table 3, each sample and matched group are to the suppression Tachistoscope result of collagenase activity.
Often organize sample test and repeat 3 times, and do not add Collagenase and be blank group and compare and can find that each group of sample is all fine to the suppression ratio of collagenase activity.And, compare discovery with matched group 3, for each sample, although ultimate density is very low, show the effect well suppressing collagenase activity.Therefore, such experimental result illustrates, cosmetic material compositions of the present invention has the effect well suppressing collagenase activity, than using independent material to have the effect better suppressing collagenase activity, has the effect preventing skin aging.
Experimental example 3: in table 1, the cosmetic material compositions of skin aging that prevents of various proportioning suppresses the mensuration of elastic fiber enzymatic activity.
In table 1, each sample is to the suppression level determinations of elastic fiber enzymatic activity, measured by methods such as Cannell: use N-succinyl-L-alanyl-L-Ala-L-Ala-4-nitroaniline as substrate, at 37 DEG C, 20 minutes periods, measure by the growing amount of substrate formed paranitroanilinum under 405nm.Concrete grammar is as follows: prepare each experimental solutions according to finite concentration (100 μ g/ml), respectively get 0.5ml and put into test tube, at 0.15ml tris-HCl buffer (50mM, pH 8.6) in add porcine pancreatic elastase (2.5 U/ml) solution (preparing with water) 0.5 ml of dissolving after, add with water-soluble N-succinyl-L-alanyl-L-Ala-L-Ala-4-nitroaniline (0.5 ㎎/ml) 100 μ l again, react after 20 minutes, measure.
In table 1, each sample and the suppression ratio of matched group to elastic fiber enzymatic activity show with the interpolation of sample solution and the absorbance reduction rate that do not add pancreatopeptidase E.The measurement result that the relevant elastic fiber enzymatic activity that forms each sample and matched group pair and wrinkle suppresses is as shown in table 4.
Table 4. each sample and matched group are to the suppression Tachistoscope result of elastic fiber enzymatic activity.
Often organize sample test and repeat 3 times, compare can find that each group of sample is all fine to the suppression ratio of elastic fiber enzymatic activity with blank group that does not add active component.And, compare discovery with matched group 3, for each sample, although ultimate density is very low, show the effect well suppressing elastic fiber enzymatic activity.Therefore, such experimental result illustrates, cosmetic material compositions of the present invention has the effect well suppressing elastic fiber enzymatic activity, than using independent material to have the effect better suppressing elastic fiber enzymatic activity, has the effect preventing skin aging.
Experimental example 4: in table 1, the skin elasticity functional examination of the cosmetic material compositions of skin aging that prevents of various proportioning is tested.
Test philosophy: lasting acoustic pressure is in minute, and the direction of the probe applied on skin, after skin is sucked into, removes acoustic pressure, skin recovers former state.Concrete method of testing is as follows: employ the equipment-Cutometer MPA580 measuring elastic force, utilize R5 value to measure the elastic force of skin.Tighten at plucked skin and be close to the probe that the diameter that attached the said equipment connects is 2 ㎜, carry out non-invasive measurement.Before using sample, the elastic force degree that skin elasticity measuring instrument is measured skin, as blank group, arm is smeared each sample 25ml/cm
2.After smearing, through 1 as a child, skin elasticity degree was measured.Be adjusted to 20 DEG C in temperature, humidity be 50% ambient temperature and moisture indoor measure.The measured men and women to liking 20 years old ~ 30 years old, totally 20.By test, the comparison having carried out elastic force improvement rate calculates.Experimental result is as shown in table 5 below.
Table 5, the skin elasticity functional examination result of each sample and matched group.
As can be seen from table 5 measurement result, cosmetic material compositions of the present invention in contrast to single hyaluronic acid, poly-γ glutamic acid or Folium Braseniae Schreberi extract, has superior enhancement beyond imagination and improves the effect of skin elasticity.
Experimental example 5: in table 1, the moistening effect of the cosmetic material compositions of skin aging that prevents of various proportioning measures.
In order to measure the moistening effect of each cosmetic material compositions of producing according to the proportioning of table 1, test for object with the men and women 20 (man 5, female 15) of 22 ~ 33 years old of dermatopathy that do not have that can be subject to experimental result impact completely.Concrete grammar is as follows: each experimental subject, before sample, after first using water cleaning experiment position, then adapts to external environment condition 30 minutes.The environmental condition of experiment is: keep indoor temperature 22 ~ 24 DEG C, indoor humidity 45 ~ 50%, and test in same place.At inboard arm with 2 × 2cm
2smear each 10 μ l of sample, and dry 1 minute.Then respectively coat the ultra-pure water of 20 μ l again at the position of smearing, towel off solid carbon dioxide divide after with 1 be divided into interval (0 point, 1 point, 2 points, 3 points, 4 points, 5 points, 6 points, 7 points, 8 points, 9 points, 10 points), with Corneometer CM 825, mensuration moistening effect is carried out to each skin surface moisture smearing part.Measurement result is as shown in table 6, and unit is Corneometer value (Cv).
Table 6, the moistening effect measurement result of each sample and matched group.
As can be seen from table 6 measurement result, cosmetic material compositions of the present invention in contrast to single hyaluronic acid, and poly-γ glutamic acid or Folium Braseniae Schreberi extract, have remarkable moistening effect.
Cosmetics 1: toner/smoothing toner (astringent)
The toner/smoothing toner (astringent) of the cosmetic material compositions containing sample 1, according to the composition proportion of following table 7, produces according to conventional methods.
Table 7, the proportioning raw materials of toner/smoothing toner (astringent).
Cosmetics 2: nutrition astringent (emulsion)
The nutrition astringent (emulsion) of the cosmetic material compositions containing sample 1, according to the composition proportion of following table 8, produces according to conventional methods.
Table 8, the proportioning raw materials of nutrition astringent (emulsion).
Cosmetics 3: nourishing cream
The nourishing cream of the cosmetic material compositions containing sample 1, according to the composition proportion of following table 9, produces according to conventional methods.
Table 9, the proportioning raw materials of nourishing cream.
Cosmetics 4: essence
The essence of the cosmetic material compositions containing sample 1, according to the composition proportion of following table 10, produces according to conventional methods.
Table 10, the proportioning raw materials of essence.
Cosmetics 5: foundation cream
The foundation cream of the cosmetic material compositions containing sample 1, according to the composition proportion of following table 11, produces according to conventional methods.
Table 11, the proportioning raw materials of foundation cream.
Finally should be noted that: above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit, and to not departing from any amendment of spirit and scope of the invention or equivalent replacement, it all should be encompassed in the middle of right of the present invention.
Claims (4)
1. prevent a cosmetic material compositions for skin aging, it is characterized in that, comprise Folium Braseniae Schreberi extract, hyaluronic acid and poly-γ glutamic acid, described Folium Braseniae Schreberi extract, the mass ratio of hyaluronic acid and poly-γ glutamic acid is 2 ~ 5: 2 ~ 5: 2 ~ 5.
2. Folium Braseniae Schreberi extract according to claim 1, is characterized in that, described hyaluronic mean molecule quantity is 500,000 ~ 3,000,000 dalton, and the mean molecule quantity of poly-γ glutamic acid is 1,000,000 ~ 5,000,000 dalton.
3. prevent cosmetics for skin aging, it is characterized in that, the raw material composition of these cosmetics comprises cosmetic material compositions according to claim 1, and wherein, the mass percent of described cosmetic material compositions in the raw material composition of cosmetics is 1-3%.
4. a kind of cosmetics preventing skin aging according to claim 3, is characterized in that, these cosmetics are toner/smoothing toner, emulsion, nourishing cream, essence and foundation cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510207781.6A CN104800124B (en) | 2015-04-28 | 2015-04-28 | It is a kind of to prevent the cosmetic material composition of skin aging and the cosmetics containing the cosmetic material composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510207781.6A CN104800124B (en) | 2015-04-28 | 2015-04-28 | It is a kind of to prevent the cosmetic material composition of skin aging and the cosmetics containing the cosmetic material composition |
Publications (2)
| Publication Number | Publication Date |
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| CN104800124A true CN104800124A (en) | 2015-07-29 |
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| CN104940064A (en) * | 2015-06-17 | 2015-09-30 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Brasenia schreberi emulsion |
| CN104958205A (en) * | 2015-06-17 | 2015-10-07 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield essential lotion |
| CN106074262A (en) * | 2016-07-04 | 2016-11-09 | 郭传明 | Compositions containing Semen Castaneae and its preparation method and application |
| CN107375142A (en) * | 2017-08-03 | 2017-11-24 | 西南大学 | A kind of preparation method of Chinese medicine beauty antiwrinkle cream |
| CN108158884A (en) * | 2018-02-01 | 2018-06-15 | 百朗德生物化学(海门)有限公司 | With the cosmetic material composition and its application in cosmetics for inhibiting allergy, function of delaying senility |
| CN108982759A (en) * | 2018-06-06 | 2018-12-11 | 上海家化联合股份有限公司 | Beauty product moistens the test method of ability to human skin |
| CN110604713A (en) * | 2019-10-30 | 2019-12-24 | 利川市常大产业技术研究院有限公司 | Essence containing water shield extract and preparation method thereof |
| CN115957170A (en) * | 2023-01-10 | 2023-04-14 | 娇时日化（杭州）股份有限公司 | Foundation make-up liquid and preparation method thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940064A (en) * | 2015-06-17 | 2015-09-30 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Brasenia schreberi emulsion |
| CN104958205A (en) * | 2015-06-17 | 2015-10-07 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield essential lotion |
| CN104958205B (en) * | 2015-06-17 | 2018-01-05 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield essence lotion |
| CN106074262A (en) * | 2016-07-04 | 2016-11-09 | 郭传明 | Compositions containing Semen Castaneae and its preparation method and application |
| CN107375142A (en) * | 2017-08-03 | 2017-11-24 | 西南大学 | A kind of preparation method of Chinese medicine beauty antiwrinkle cream |
| CN107375142B (en) * | 2017-08-03 | 2019-07-26 | 西南大学 | A kind of preparation method of Chinese medicine beauty antiwrinkle cream |
| CN108158884A (en) * | 2018-02-01 | 2018-06-15 | 百朗德生物化学(海门)有限公司 | With the cosmetic material composition and its application in cosmetics for inhibiting allergy, function of delaying senility |
| CN108982759A (en) * | 2018-06-06 | 2018-12-11 | 上海家化联合股份有限公司 | Beauty product moistens the test method of ability to human skin |
| CN110604713A (en) * | 2019-10-30 | 2019-12-24 | 利川市常大产业技术研究院有限公司 | Essence containing water shield extract and preparation method thereof |
| CN115957170A (en) * | 2023-01-10 | 2023-04-14 | 娇时日化（杭州）股份有限公司 | Foundation make-up liquid and preparation method thereof |
| CN115957170B (en) * | 2023-01-10 | 2024-03-12 | 娇时日化（杭州）股份有限公司 | Foundation liquid and preparation method thereof |
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