CN108158884A - With the cosmetic material composition and its application in cosmetics for inhibiting allergy, function of delaying senility - Google Patents

With the cosmetic material composition and its application in cosmetics for inhibiting allergy, function of delaying senility Download PDF

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Publication number
CN108158884A
CN108158884A CN201810100682.1A CN201810100682A CN108158884A CN 108158884 A CN108158884 A CN 108158884A CN 201810100682 A CN201810100682 A CN 201810100682A CN 108158884 A CN108158884 A CN 108158884A
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China
Prior art keywords
extract
function
allergy
water shield
material composition
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CN201810100682.1A
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Chinese (zh)
Inventor
金基洙
赖培辉
金庚泰
卢勇
陈秀玉
刘晓磊
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Guangzhou Mei Ran Cosmetics Co Ltd
100 Landes Biochemistry (haimen) Co Ltd
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Guangzhou Mei Ran Cosmetics Co Ltd
100 Landes Biochemistry (haimen) Co Ltd
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Priority to CN201810100682.1A priority Critical patent/CN108158884A/en
Publication of CN108158884A publication Critical patent/CN108158884A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10General cosmetic use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses with inhibition allergy,The cosmetic material composition of function of delaying senility,It is 1 ~ 5% that water shield extract, which accounts for composition total weight proportioning,,It is 5 ~ 10% that sea grape extract, which accounts for composition total weight proportioning,,It is 2 ~ 5% that saccharomycete/laminariose tunning, which accounts for composition total weight proportioning,,Cosmetic base surplus,Water shield extract and sea grape extract of the present invention have anti-oxidant well,The substance of senile-resistant efficacy,Antioxidant in water shield extract and sea grape extract removes free radical and reaches inhibition allergy and anti-aging function,Different amounts of collagen and ferment are supplemented according to different products,Skin can be helped preferably to absorb the active ingredient in cosmetics,So as to which effect is put into maximization,Active constituent is extracted all from sea-plant and is obtained,And the active constituent in sea grape extract has the function of to inhibit allergy,It is pure natural,It is non-stimulated,Meet the requirement of cosmetics addition.

Description

With the cosmetic material composition for inhibiting allergy, function of delaying senility and its changing Application in cosmetic
Technical field
The present invention relates to a kind of cosmetic material compositions, more particularly to a kind of to have inhibition allergy, function of delaying senility Cosmetic material composition and its application in cosmetics.
Background technology
Water shield also known as horseshoe dish, lake dish etc. are perennial aquatic perennial root draft.Water shield is the traditional rare aquatic vegetable in China Dish has abundant nutritive value and medical value.As vegetables, abundant collagen, carbon hydrate are contained in water shield Object, multivitamin and minerals.As medicinal material, water shield has the effect of controlling hot subcutaneous ulcer, thick stomach, An Xiajiao, hundred medicines of solution are malicious again. Research shows that Polysaccharide of Brasenia Schreberi is one of main component in water shield, be primarily present in the colloid on water shield surface, have it is antitumor, Antibacterial etc. the effect of anti-oxidant, hypoglycemic and anti-inflammatory, there is good health-care efficacy.Sea grape scientific name is long shoot grape, is a kind of Consumption green alga full of nutrition has the title of " green caviar ".Sea grape 80% is by algal polysaccharides, collagen and diet Fiber forms, and amino acid composition is balanced and A wide selection of colours and designs, and fat content is relatively low and mostly unrighted acid, minerals and Wei Sheng Cellulose content enriches.Anti-aging, anti-oxidant, moisturizing and antiallergy for having about sea grape and other effects it is early several years ago just by Patent authenticated.Kelp is also known as " black dish ", Phaeophyceae, Alariaceae.It is grown in the ocean of temperate zone.Kelp is a kind of with very high The seaweed of medical value.Kelp category has two kinds, and China only has one kind, i.e. kelp, is the water warm algae of North Western Pacific Class.Kelp nature and flavor are trembled with fear, salty.Have softening and resolving hard mass, detumescencing diuresis, mild laxation dissolving phlegm work(, clinically for goitre, neck lymph Knot is swollen, bronchitis, pulmonary tuberculosis, cough and cataract of old people etc., also try out in treating cancer.And extracted in kelp Polysaccharide has good moisture-keeping function and antitoxic action.
Invention content
The purpose of the present invention is to provide it is a kind of have inhibit allergy, function of delaying senility cosmetic material composition and Its application in cosmetics.
The technical solution adopted by the present invention is:
With the cosmetic material composition for inhibiting allergy, function of delaying senility, which is characterized in that including following component:Water shield Extract, sea grape extract, saccharomycete/laminariose tunning, cosmetic base, it is total that the water shield extract accounts for composition Weight proportion is 1 ~ 5%, and it is 5 ~ 10% that the sea grape extract, which accounts for composition total weight proportioning, the saccharomycete/laminariose hair It is 2 ~ 5% that ferment product, which accounts for composition total weight proportioning, cosmetic base surplus.
The water shield extract is by the way that water shield is crushed, degreasing, carry out supercritical reaction, extracted by organic reagent, from The heart, elution, drying obtain water shield extract, and the sea grape extract is obtained by homogenate extraction method, i.e., sea grape is by washing It washs, dry, crushing, solvent extraction, purifying, filtering and be concentrated to give sea grape extract, the reagent used in extraction process For water or the mix reagent of water and organic solvent, the saccharomycete/laminariose tunning is passed through using 80% laminariose to be configured Culture medium, sterilizing, culture medium label, inoculation, culture, result observation and detection obtain saccharomycete/laminariose tunning.
The organic reagent is one or more of petroleum ether, phenol reagent, and the organic solvent is 1,3- fourths two One or more of alcohol, 1,3- propylene glycol, dipropylene glycol, G & W.
With application of the cosmetic material composition in cosmetics for inhibiting allergy, function of delaying senility.
The cosmetic material composition, which can be made in toner, lotion, Essence, gel, spray water, arbitrarily to be chosen A dosage form.
Advantages of the present invention:Water shield extract and sea grape extract have good anti-oxidant, senile-resistant efficacy object Matter, the antioxidant in water shield extract and sea grape extract remove free radical and reach the work(for inhibiting allergy and anti-aging Effect supplements different amounts of collagen and ferment according to different products, skin can be helped preferably to absorb in cosmetics Active ingredient, so as to which effect is put into maximization, active constituent is extracted all from sea-plant and is obtained, and sea grape carries The active constituent in object is taken to have the function of to inhibit allergy, it is pure natural, it is non-stimulated, meet the requirement of cosmetics addition.
Description of the drawings
Fig. 1 gold water locks Essence removes DPPH free radical schematic diagrames.
Specific embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, the embodiment It is only used for explaining the present invention, not restrict the protection scope of the present invention.
Embodiment 1:
The cosmetic material composition with inhibition allergy, function of delaying senility of the present invention, including:Water shield extract, extra large Portugal Grape extract, saccharomycete/laminariose tunning, cosmetic base, dosage form are sprayed for fermentation.
Water shield extract is by the way that water shield is crushed, degreasing, carries out supercritical reaction, extracted, centrifuged by organic reagent, eluted, It is dry, water shield extract is obtained, supercritical extract temperature is 50 DEG C, extracting pressure 20MPa, centrifuge speed 3000r/ Min, time 10min;
Sea grape extract is obtained by homogenate extraction method, i.e., sea grape by washing, drying, crushing, solvent extraction, purifying, Filter and be concentrated to give sea grape extract, mixing examination of the reagent used in extraction process for water or water and organic solvent Agent, the temperature of concentration is 70-80 DEG C, pressure 0.5-0.8Mpa;
Saccharomycete/laminariose tunning using 80% laminariose by be configured culture medium, sterilizing, culture medium mark, inoculation, Culture, result observation and detection obtain saccharomycete/laminariose tunning, peptone are contained in culture medium, sterilizing is using high pressure Autoclave, culture are constant temperature 37 DEG C, 24 hours using constant incubator, thermostatic drying chamber, condition of culture;
Organic reagent is petroleum ether, one or more of phenol reagent, and organic solvent is 1,3-BDO, 1,3- the third two One or more of alcohol, dipropylene glycol, G & W.
Specific formula(It weighs by weight percentage):Water shield extract 1%;Sea grape extract 5%;Saccharomycete/laminariose Tunning 5%;Micromolecule hyaluronic acid sodium 0.3%;Hydrolyzed Collagen 0.25%;Vc phosphates magnesium 0.1%;Dipotassium glycyrrhizinate salt 0.05%;Glycerine 5%;Camomile extract 1%;Poncirin 0.3%;Dried tremella extract 3%;Hamamelis extract 0.8%;To hydroxyl Benzoylformaldoxime 0.3%;1,2- hexylene glycols 1.5%;Perfume essential oil 0.025%;Rilanit special 0.0025%;Yeast tunning extracts Object is added to 100%.
Embodiment 2:
The cosmetic material composition with inhibition allergy, function of delaying senility of the present invention, including:Water shield extract, extra large Portugal Grape extract, saccharomycete/laminariose tunning, cosmetic base, dosage form are eye patch Essence.
Water shield extract is by the way that water shield is crushed, degreasing, carries out supercritical reaction, is extracted, centrifuged, washed by organic reagent It is de-, dry, water shield extract is obtained, supercritical extract temperature is 50 DEG C, extracting pressure 20MPa, and centrifuge speed is 3000r/min, time 10min;
Sea grape extract is obtained by homogenate extraction method, i.e., sea grape by washing, drying, crushing, solvent extraction, purifying, Filter and be concentrated to give sea grape extract, mixing examination of the reagent used in extraction process for water or water and organic solvent Agent, the temperature of concentration is 70-80 DEG C, pressure 0.5-0.8Mpa;
Saccharomycete/laminariose tunning using 80% laminariose by be configured culture medium, sterilizing, culture medium mark, inoculation, Culture, result observation and detection obtain saccharomycete/laminariose tunning, peptone are contained in culture medium, sterilizing is using high pressure Autoclave, culture are constant temperature 37 DEG C, 24 hours using constant incubator, thermostatic drying chamber, condition of culture;
Organic reagent is petroleum ether, one or more of phenol reagent, and organic solvent is 1,3-BDO, 1,3- the third two One or more of alcohol, dipropylene glycol, G & W.
Specific formula(It weighs by weight percentage):Water shield extract 1%;Sea grape extract 5%;Saccharomycete/laminariose Tunning 5%;EDTA-2Na 0.05%;Sodium Hyaluronate 0.02%;Hydroxyethyl cellulose 0.15%;Carbomer 0.25%;Glycerine 5%;Glycerin polyether -26 2%;Triethanolamine 0.25%;Elastin 0.05%;Magnesium ascorbyl phosphate 0.25%;Asiaticosid 0.02%;Ursin 0.8%;Amino acid complex 1%;Horse chestnut seed extract 0.5%;Parahydroxyacet-ophenone 0.5%;1,2- oneself two Alcohol 2%;Perfume essential oil 0.01%;Deionized water adds to 100%.
Embodiment 3:
The cosmetic material composition with inhibition allergy, function of delaying senility of the present invention, including:Water shield extract, extra large Portugal Grape extract, saccharomycete/laminariose tunning, cosmetic base, dosage form are sodium hyaluronate stoste.
Water shield extract is by the way that water shield is crushed, degreasing, carries out supercritical reaction, is extracted, centrifuged, washed by organic reagent It is de-, dry, water shield extract is obtained, supercritical extract temperature is 50 DEG C, extracting pressure 20MPa, and centrifuge speed is 3000r/min, time 10min;
Sea grape extract is obtained by homogenate extraction method, i.e., sea grape by washing, drying, crushing, solvent extraction, purifying, Filter and be concentrated to give sea grape extract, mixing examination of the reagent used in extraction process for water or water and organic solvent Agent, the temperature of concentration is 70-80 DEG C, pressure 0.5-0.8Mpa;
Saccharomycete/laminariose tunning using 80% laminariose by be configured culture medium, sterilizing, culture medium mark, inoculation, Culture, result observation and detection obtain saccharomycete/laminariose tunning, peptone are contained in culture medium, sterilizing is using high pressure Autoclave, culture are constant temperature 37 DEG C, 24 hours using constant incubator, thermostatic drying chamber, condition of culture;
Organic reagent is petroleum ether, one or more of phenol reagent, and organic solvent is 1,3-BDO, 1,3- the third two One or more of alcohol, dipropylene glycol, G & W.
Specific formula(It weighs by weight percentage):Water shield extract 2%;Sea grape extract 10%;Saccharomycete/laminariose Tunning 5%;Micromolecule hyaluronic acid sodium 0.3%;Macromolecular Sodium Hyaluronate 0.1%;Hydrolyzed Collagen 0.2%;Elastic force egg White 0.05%;1,3- propylene glycol 3%;Aloe vera extract 1%;Parahydroxyacet-ophenone 0.5%;1,2- hexylene glycols 2.5%;Yeast Tunning extract adds to 100%.
The effect of cosmetic material composition removing DPPH free radicals of the present invention is as follows:
First, reagent prepares:3.943mgDPPH is settled to 50mL with 95% ethyl alcohol;10mg or so Trolox are settled to 95% ethyl alcohol 100mL;It is a kind of that there is the cosmetic material composition for inhibiting allergy and slowing down aging.
2nd, experimental procedure
1.UV schools zero, 95% ethyl alcohol is as blank sample
2. preliminary experiment(DPPH concentration selects)
500 μ L DPPH+1000 μ L, 95% ethyl alcohol shakes 10s, stands 10min, surveys absorbance value(Absorbance value at 520nm 0.45-0.55 can then be used as following experiment DPPH solution)
The measure of 3.Trolox
After adding in DPPH or 95% ethyl alcohol, 10s is shaken, stands 10min, surveys absorbance value.
4. experiment
After adding in DPPH or 95% ethyl alcohol, 10s is shaken, stands 10min, surveys absorbance value.
3rd, experimental result
As a result:Gold water lock Essence plays the role of removing DPPH free radicals well, and IC50 values are 210000 μ g/mL.
Conclusion:Gold water lock Essence plays the role of removing DPPH free radicals.
The present invention uses water shield extract, sea grape extract and saccharomycete/laminariose tunning to match for active constituent Other extracts and cosmetic base are closed, reaches and inhibits allergy and oxidation resistant effect.Water shield extract and sea in the present invention Grape extract is all generally acknowledged with good anti-oxidant, senile-resistant efficacy substance, passes through Experimental comparison repeatedly and inspection It surveys, finally determines most suitable adding proportion, so as to which three's effect is used maximization.The present invention inhibits allergy and anti-aging The effect of be that the effect of free radical is removed by antioxidant in water shield extract and sea grape extract to reach, root Supplement different amounts of collagen and ferment according to different product, can help skin preferably absorb in cosmetics it is effective into Point, so as to which the effect of present invention, is put into maximization.Furthermore the active constituent in the present invention is extracted from sea-plant It arrives, and the active constituent in sea grape extract has the function of to inhibit allergy, it is pure natural, it is non-stimulated, meet cosmetics The requirement of addition.

Claims (5)

1. with the cosmetic material composition for inhibiting allergy, function of delaying senility, which is characterized in that including following component:Water shield Dish extract, sea grape extract, saccharomycete/laminariose tunning, cosmetic base, the water shield extract account for composition Total weight proportioning is 1 ~ 5%, and it is 5 ~ 10% that the sea grape extract, which accounts for composition total weight proportioning, the saccharomycete/laminariose It is 2 ~ 5% that tunning, which accounts for composition total weight proportioning, cosmetic base surplus.
2. the cosmetic material composition according to claim 1 with inhibition allergy, function of delaying senility, feature exist In:The water shield extract is by the way that water shield is crushed, degreasing, carries out supercritical reaction, is extracted, centrifuged, washed by organic reagent It is de-, dry, water shield extract is obtained, the sea grape extract is obtained by homogenate extraction method, i.e., sea grape is by washing, doing Dry, crushing, purifying, filters and is concentrated to give sea grape extract solvent extraction, the reagent used in extraction process for water or The mix reagent of water and organic solvent, the saccharomycete/laminariose tunning is using 80% laminariose by the way that culture is configured Base, sterilizing, culture medium label, inoculation, culture, result observation and detection obtain saccharomycete/laminariose tunning.
3. the cosmetic material composition according to claim 2 with inhibition allergy, function of delaying senility, feature exist In:The organic reagent is petroleum ether, one or more of phenol reagent, and the organic solvent is 1,3-BDO, 1, One or more of 3-propanediol, dipropylene glycol, G & W.
4. with application of the cosmetic material composition of allergy, function of delaying senility in cosmetics is inhibited.
5. the cosmetic material composition according to claim 1 with inhibition allergy, function of delaying senility, feature exist In:The cosmetic material composition can be made arbitrarily chosen in toner, lotion, Essence, gel, spray water it is a Dosage form.
CN201810100682.1A 2018-02-01 2018-02-01 With the cosmetic material composition and its application in cosmetics for inhibiting allergy, function of delaying senility Pending CN108158884A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109276486A (en) * 2018-10-16 2019-01-29 高丽雅娜化妆品(天津)有限公司 A kind of compound and preparation method thereof of the yeast extractive from fermentative of moisturizing anti-aging
CN112370404A (en) * 2020-11-25 2021-02-19 桂林理工大学 Moisturizing and whitening composition, and preparation method and application thereof
CN113230198A (en) * 2021-06-02 2021-08-10 上海佩威化妆品有限公司 Anti-wrinkle anti-aging freeze-dried essence and preparation method thereof
CN117562836A (en) * 2023-11-17 2024-02-20 清远市望莎生物科技有限公司 Composite seaweed fermentation extract, preparation method, application and daily chemical product thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800124A (en) * 2015-04-28 2015-07-29 百朗德生物化学海门有限公司 Cosmetic raw material composition for preventing skin aging and cosmetics containing same
CN106562894A (en) * 2016-10-12 2017-04-19 广东药科大学 Skin-whitening, anti-aging and anti-allergic hesperidin composition, application and preparation
CN106994135A (en) * 2016-01-22 2017-08-01 德丰铭国际股份有限公司 It is a kind of that there is the sea grape extract for suppressing allergy function, preparation method and application
CN107510042A (en) * 2017-08-14 2017-12-26 刘桂连 Seaweed nutritive liquid and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104800124A (en) * 2015-04-28 2015-07-29 百朗德生物化学海门有限公司 Cosmetic raw material composition for preventing skin aging and cosmetics containing same
CN106994135A (en) * 2016-01-22 2017-08-01 德丰铭国际股份有限公司 It is a kind of that there is the sea grape extract for suppressing allergy function, preparation method and application
CN106562894A (en) * 2016-10-12 2017-04-19 广东药科大学 Skin-whitening, anti-aging and anti-allergic hesperidin composition, application and preparation
CN107510042A (en) * 2017-08-14 2017-12-26 刘桂连 Seaweed nutritive liquid and preparation method thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109276486A (en) * 2018-10-16 2019-01-29 高丽雅娜化妆品(天津)有限公司 A kind of compound and preparation method thereof of the yeast extractive from fermentative of moisturizing anti-aging
CN112370404A (en) * 2020-11-25 2021-02-19 桂林理工大学 Moisturizing and whitening composition, and preparation method and application thereof
CN112370404B (en) * 2020-11-25 2022-09-16 桂林理工大学 Moisturizing and whitening composition, and preparation method and application thereof
CN113230198A (en) * 2021-06-02 2021-08-10 上海佩威化妆品有限公司 Anti-wrinkle anti-aging freeze-dried essence and preparation method thereof
CN117562836A (en) * 2023-11-17 2024-02-20 清远市望莎生物科技有限公司 Composite seaweed fermentation extract, preparation method, application and daily chemical product thereof
CN117562836B (en) * 2023-11-17 2024-04-26 清远市望莎生物科技有限公司 Composite seaweed fermentation extract, preparation method, application and daily chemical product thereof

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Applicant before: 100 Landes Biochemistry (Haimen) Co. Ltd.

Applicant before: Guangzhou Mei ran Cosmetics Co., Ltd.

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Application publication date: 20180615

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