CN110179709A - A kind of moisturizing Shu Min complex liquid and the preparation method and application thereof - Google Patents

A kind of moisturizing Shu Min complex liquid and the preparation method and application thereof Download PDF

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CN110179709A
CN110179709A CN201910533891.XA CN201910533891A CN110179709A CN 110179709 A CN110179709 A CN 110179709A CN 201910533891 A CN201910533891 A CN 201910533891A CN 110179709 A CN110179709 A CN 110179709A
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extract
added
shu min
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filtering
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不公告发明人
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Heilongjiang Runbiao Brand Management Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/75Anti-irritant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84Products or compounds obtained by lyophilisation, freeze-drying

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Abstract

The present invention provides a kind of moisturizing Shu Min complex liquids and the preparation method and application thereof, and method includes the following steps: S1, produces dried tremella extract;S2, trifoliate orange berry extract is produced;S3, golden yellow chamomile raw material is chosen, 5-10 times 50% of ethyl alcohol is added, the pH to 8 or so that proper amount of sodium citrate adjusts extracting solution is added, room temperature extracts 48 hours, the filtering of 1um filter paper obtains golden yellow camomile extract;S4, purslane raw material is chosen, 5-10 times of water is added, Microwave Extraction 30-60 minutes, the filtering of 1um filter paper obtains Purslane extract;S5, by S1-S4 obtain 4 Plant Extracts, according to claim 1 in composition of raw materials, compounded in proportion, obtain moisturizing Shu Min complex liquid.In cosmetic technical field, people increasingly detest the chemical reagent of synthesis, and natural raw material is more and more interested, and present solution provides one kind to mix moisturizing Shu Min complex liquid by 4 Plant Extracts.

Description

A kind of moisturizing Shu Min complex liquid and the preparation method and application thereof
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of moisturizing Shu Min complex liquid and preparation method thereof with answer With.
Background technique
With the raising of the level of consumption of people, requirement of the people to cosmetic product is also increasingly stringenter, not merely Only meet both effectiveness level, also more stringent requirements are proposed to cosmetics safety by people.People are more next to the chemical reagent of synthesis More detest, natural raw material is more and more interested, and under this trend, the cosmetics of natural components are becoming increasingly popular.China A kind of Shu Min creams with anti-inflammatory efficacy of patent CN109010115A.The Shu Min creams composition are as follows: palmityl tripeptides -8, second Acyl group tetrapeptide -15, -1 copper of tripeptides, camellia seed oil extract, jojoba seed oil, phytosterol isostearate, Butyrospermum parkii fruit Rouge, golden yellow camomile extract, licorice, Dendrobium officinale polysaccharide, dried tremella extract, beta glucan, moisturizer, emulsification Agent, skin conditioning agent, thickener, antioxidant, preservative, pH adjusting agent and pure water.The present invention passes through palmityl tripeptides -8, second Acyl group tetrapeptide -15 and -1 copper of tripeptides are combined with plant extracts, have very significant antibacterial and anti-inflammatory effects. A kind of desensitization cosmetic composition of CN105496907A and desensitization method, wherein the desensitization cosmetic composition includes ground Slurry and ground slurry essence lotion, can be realized good desensitization effect, and it is not yet found that any side effect.
Summary of the invention
It is more next to natural raw material to overcome people existing in the prior art increasingly to detest the chemical reagent of synthesis Problem interested uses 4 Plant Extracts the present invention provides a kind of, according to a certain percentage, the one of mixing compounding acquisition Kind moisturizing Shu Min complex liquid, composition of raw materials includes: 2-10% dried tremella extract, 2-8% trifoliate orange berry extract, the golden yellow ocean 1-7% Flos Chrysanthemi extract, 1-10% purslane extract, 20-30% butanediol, surplus are deionized water.
By using above-mentioned technical proposal, dried tremella extract to collagenase activity, and to other it is several it is biochemical at It is mitogenetic at facilitation and the crease-resistant effect of skin-active;Extract is still used as moisturizer, skin-whitening agents and skin allergy and inhibits Agent.Trifoliate orange berry extract, is usually used in facial mask, has the effect of that moisturizing sterilization and whitening, golden yellow camomile extract can divide The triterpene compound of 27 kinds of anti-inflammatory effects is separated out, dermatitis can be treated, has inhibiting effect to the inductivity allergy of skin;It can enhance The resistance of capillary inhibits capillary permeability and has anti-inflammatory effect;Free radical can be eliminated simultaneously, is had anti-oxidant Property, have and alleviates aging effect;Also there is certain inhibiting effect to melanocyte, so there is the effect of certain whitening spot-removing. Purslane extract rich in there is the compounds such as a large amount of flavonoids, adrenin, polysaccharide and various vitamins, amino acid, It is mainly used for the various stimulations of antiallergy, anti-inflammatory anti-inflammatory and anti-outer bound pair skin, especially to long-time service steroids makeup The skin allergy that product generate has apparent anti-allergic effects.Butanediol is the polyalcohols being gentle, be small molecule moisturizing at Part, it is small to grab water ratio, does moisturizer and solvent in makeup kind, while also having certain bacteriostasis.
A kind of preparation method of moisturizing Shu Min complex liquid: S1, choosing tremella raw material, and 10-20 times of water, 95-100 DEG C of height is added Temperature extracts 60-120min, filtered through gauze, and 65-75 DEG C of vacuum distillation filtered fluid is concentrated into filtrate is original 1/3, is cooled to room The 50-70% ethyl alcohol of 2-5 times of filtrate quality is added in Wen Hou, stirs 10-15 minutes, 1-2 hours static, and filtering retains filter residue, does Dry filter residue obtains dried tremella extract;S2, trifoliate orange fruit raw material is chosen, pulverizer crushes, and 2-5 times of methanol, 50-60 DEG C of reflux is added Extract 2-3 hours, the filtering of 1um filter paper, 60-70 DEG C of reduced pressure filtering to no methanol residual, moisture content 3% hereinafter, Obtain trifoliate orange berry extract;S3, golden yellow chamomile raw material is chosen, 5-10 times 50% of ethyl alcohol is added, appropriate citric acid is added Sodium adjusts the pH to 8 of extracting solution, and room temperature extracts 48 hours, the filtering of 1um filter paper obtains golden yellow camomile extract;S4, selection 5-10 times of water is added in purslane raw material, and Microwave Extraction 30-60 minutes, the filtering of 1um filter paper obtains Purslane extract;S5, By S1-S4 obtain 4 Plant Extracts, according to claim 1 in composition of raw materials, compounded in proportion, obtain moisturizing Shu Min complex liquid.
Preferably, the drying filter residue in the S1 uses freeze-drying, the freeze-drying is cold using vacuum One of dry and microwave freeze-drying is lyophilized.
By using above-mentioned technical proposal, freeze-drying will not make product turn to be yellow and go bad, and can guarantee that tremella mentions The stabilization of physical property matter is taken, moisture can be sublimated directly to gas, energy from solid by vacuum freeze drying and microwave freeze-drying method The enough validity for keeping extract well.
Preferably, vacuum freeze drying temperature controls in -10 DEG C~-5 DEG C sections, and high vacuum is exhausted in the S1 To in the container of pressure 10-133Pa, the microwave freeze-drying is temperature to be first reduced to -25 DEG C, then carry out in three stages micro- Wave is dry, and microwave power is respectively 200w/kg, 400w/kg and 150w/kg, and the time ratio of microwave is 1:3:2 three times.
It is big with the external world in container by passing through after cryogenic freezing by using above-mentioned technical proposal, in vacuum freeze drying The negative pressure that air pressure generates, to be dried, the microwave freeze-drying also needs first to cool down, using triphasic progress Microwave drying, microwave power arrive low, low-power short time operation, long-play when high power, to pass through again from low to high Interim power adjustment, can quickly achieve the effect that dry.
Preferably, the golden yellow camomile extract in the S3 mainly includes bisabolol.
Preferably, temperature is controlled at 20 DEG C ± 2 DEG C, ambient humidity 40-60% in compound process in the S5, and nothing The interior of direct sunlight and light direct projection.
Preferably, complex liquid is for moistening face centella flesh essence dew living, profit face lily isolating and protecting frost, HERBA DENDROBII Fixing in youth, clearly cream, nine grace plant the shining face liquid of extraction, water light Essence, tie up E victory peptide for liquid, soapberry betaplex gentle cleansing milk, plant extraction skin-active Compact eye cream, profit face ginseng shine and adopt in facial mask.
By using above-mentioned technical proposal, cosmetic composition uses 4 Plant Extracts, according to a certain percentage, mixing The moisturizing Shu Min complex liquid obtained is compounded, golden yellow camomile extract therein and purslane extract can effectively inhibit skin Skin allergy, wherein purslane has apparent anti-allergic effects, trifoliate orange to the skin allergy that steroids cosmetics generate is used for a long time Fruit extracting solution has the function of that sterilization and whitening, dried tremella extract can activate golden yellow camomile extract, purslane extract Generation with trifoliate orange fruit extracting solution biochemical has facilitation while having certain moisturizing, whitening and antianaphylactic function, Butanediol is the main moisture-keeping functions composition of composition, therefore composition has effects that moisturizing Shu Min, extracted form natural plant, peace Quan Xinggao has the wide market space and economic value.
Preferably, the water being added in the S1-S4 is deionized water, used in Microwave Extraction in the S4 Microwave power is 50w/kg.
By using above-mentioned technical proposal, water employed in step is deionized water, removes ionic species presence The water of impurity be not easy to influence the effect of plant extracts, Microwave Extraction uses Microwave Extraction, is able to maintain the compound of script State.
Detailed description of the invention
Fig. 1 is a kind of preparation method flow chart of moisturizing Shu Min complex liquid.
Specific embodiment
Below in conjunction with drawings and examples, the present invention will be described in further detail.It should be appreciated that described herein Specific examples are only used to explain the present invention, is not intended to limit the present invention.
Embodiment 1
A kind of moisturizing Shu Min complex liquid as shown in Figure 1:, characterized by comprising: dried tremella extract 10%, trifoliate orange fruit are extracted Object 8%, golden yellow camomile extract 7%, purslane extract 3%, butanediol 30%, remaining is deionized water.
A kind of preparation method of moisturizing Shu Min complex liquid as shown in Figure 1: includes the following steps: S1, chooses tremella raw material, 15 times of water are added, 97 DEG C of high temperature extract 90min, filtered through gauze, and 70 DEG C of vacuum distillation filtered fluids are concentrated into filtrate is original 1/ 3, after being cooled to room temperature, 60% ethyl alcohol of 3 times of filtrate qualities is added, stirs 12 minutes, static 1.5 hours, filtering retained filter residue, Dry filter residue obtains dried tremella extract;S2, trifoliate orange fruit raw material is chosen, pulverizer crushes, and 3 times of methanol is added, 55 DEG C of reflux mention Take object 2.5 hours, 1um filter paper filtering, 65 DEG C of reduced pressure filtering to no methanol remain, and moisture content is 3% hereinafter, obtaining Trifoliate orange berry extract;S3, golden yellow chamomile raw material is chosen, 8 times 50% of ethyl alcohol is added, proper amount of sodium citrate is added and adjusts extraction The pH to 8 or so of liquid, room temperature extract 48 hours, the filtering of 1um filter paper obtains golden yellow camomile extract;S4, purslane is chosen 8 times of water are added in raw material, and Microwave Extraction 45 minutes, the filtering of 1um filter paper obtains Purslane extract;S5, by S1-S4 obtain 4 Plant Extracts, are compounded in proportion, obtain moisturizing Shu Min complex liquid.
Embodiment 2
A kind of moisturizing Shu Min complex liquid as shown in Figure 1:, characterized by comprising: dried tremella extract 8%, trifoliate orange fruit are extracted Object 5%, golden yellow camomile extract 5%, purslane extract 2%, butanediol 20%, remaining is deionized water.
A kind of preparation method of moisturizing Shu Min complex liquid as shown in Figure 1: includes the following steps: S1, chooses tremella raw material, 15 times of water are added, 97 DEG C of high temperature extract 90min, filtered through gauze, and 70 DEG C of vacuum distillation filtered fluids are concentrated into filtrate is original 1/ 3, after being cooled to room temperature, 60% ethyl alcohol of 3 times of filtrate qualities is added, stirs 12 minutes, static 1.5 hours, filtering retained filter residue, Dry filter residue obtains dried tremella extract;S2, trifoliate orange fruit raw material is chosen, pulverizer crushes, and 3 times of methanol is added, 55 DEG C of reflux mention Take object 2.5 hours, 1um filter paper filtering, 65 DEG C of reduced pressure filtering to no methanol remain, and moisture content is 3% hereinafter, obtaining Trifoliate orange berry extract;S3, golden yellow chamomile raw material is chosen, 8 times 50% of ethyl alcohol is added, proper amount of sodium citrate is added and adjusts extraction The pH to 8 or so of liquid, room temperature extract 48 hours, the filtering of 1um filter paper obtains golden yellow camomile extract;S4, purslane is chosen 8 times of water are added in raw material, and Microwave Extraction 45 minutes, the filtering of 1um filter paper obtains Purslane extract;S5, by S1-S4 obtain 4 Plant Extracts, are compounded in proportion, obtain moisturizing Shu Min complex liquid.
Embodiment 3
A kind of moisturizing Shu Min complex liquid as shown in Figure 1:, characterized by comprising: dried tremella extract 5%, trifoliate orange fruit are extracted Object 3%, golden yellow camomile extract 6%, purslane extract 6%, butanediol 25%, remaining is deionized water.
A kind of preparation method of moisturizing Shu Min complex liquid as shown in Figure 1: includes the following steps: S1, chooses tremella raw material, 15 times of water are added, 97 DEG C of high temperature extract 90min, filtered through gauze, and 70 DEG C of vacuum distillation filtered fluids are concentrated into filtrate is original 1/ 3, after being cooled to room temperature, 60% ethyl alcohol of 3 times of filtrate qualities is added, stirs 12 minutes, static 1.5 hours, filtering retained filter residue, Dry filter residue obtains dried tremella extract;S2, trifoliate orange fruit raw material is chosen, pulverizer crushes, and 3 times of methanol is added, 55 DEG C of reflux mention Take object 2.5 hours, 1um filter paper filtering, 65 DEG C of reduced pressure filtering to no methanol remain, and moisture content is 3% hereinafter, obtaining Trifoliate orange berry extract;S3, golden yellow chamomile raw material is chosen, 8 times 50% of ethyl alcohol is added, proper amount of sodium citrate is added and adjusts extraction The pH to 8 or so of liquid, room temperature extract 48 hours, the filtering of 1um filter paper obtains golden yellow camomile extract;S4, purslane is chosen 8 times of water are added in raw material, and Microwave Extraction 45 minutes, the filtering of 1um filter paper obtains Purslane extract;S5, by S1-S4 obtain 4 Plant Extracts, are compounded in proportion, obtain moisturizing Shu Min complex liquid.
Embodiment 4
A kind of moisturizing Shu Min complex liquid as shown in Figure 1:, characterized by comprising: dried tremella extract 2%, trifoliate orange fruit are extracted Object 2%, golden yellow camomile extract 1%, purslane extract 3%, butanediol 25%, remaining is deionized water.
A kind of preparation method of moisturizing Shu Min complex liquid as shown in Figure 1: includes the following steps: S1, chooses tremella raw material, 15 times of water are added, 97 DEG C of high temperature extract 90min, filtered through gauze, and 70 DEG C of vacuum distillation filtered fluids are concentrated into filtrate is original 1/ 3, after being cooled to room temperature, 60% ethyl alcohol of 3 times of filtrate qualities is added, stirs 12 minutes, static 1.5 hours, filtering retained filter residue, Dry filter residue obtains dried tremella extract;S2, trifoliate orange fruit raw material is chosen, pulverizer crushes, and 3 times of methanol is added, 55 DEG C of reflux mention Take object 2.5 hours, 1um filter paper filtering, 65 DEG C of reduced pressure filtering to no methanol remain, and moisture content is 3% hereinafter, obtaining Trifoliate orange berry extract;S3, golden yellow chamomile raw material is chosen, 8 times 50% of ethyl alcohol is added, proper amount of sodium citrate is added and adjusts extraction The pH to 8 or so of liquid, room temperature extract 48 hours, the filtering of 1um filter paper obtains golden yellow camomile extract;S4, purslane is chosen 8 times of water are added in raw material, and Microwave Extraction 45 minutes, the filtering of 1um filter paper obtains Purslane extract;S5, by S1-S4 obtain 4 Plant Extracts, are compounded in proportion, obtain moisturizing Shu Min complex liquid.
Embodiment 5
A kind of moisturizing Shu Min complex liquid as shown in Figure 1:, characterized by comprising: dried tremella extract 5%, trifoliate orange fruit are extracted Object 3%, golden yellow camomile extract 3%, purslane extract 4%, butanediol 30%, remaining is deionized water.
A kind of preparation method of moisturizing Shu Min complex liquid as shown in Figure 1: includes the following steps: S1, chooses tremella raw material, 15 times of water are added, 97 DEG C of high temperature extract 90min, filtered through gauze, and 70 DEG C of vacuum distillation filtered fluids are concentrated into filtrate is original 1/ 3, after being cooled to room temperature, 60% ethyl alcohol of 3 times of filtrate qualities is added, stirs 12 minutes, static 1.5 hours, filtering retained filter residue, Dry filter residue obtains dried tremella extract;S2, trifoliate orange fruit raw material is chosen, pulverizer crushes, and 3 times of methanol is added, 55 DEG C of reflux mention Take object 2.5 hours, 1um filter paper filtering, 65 DEG C of reduced pressure filtering to no methanol remain, and moisture content is 3% hereinafter, obtaining Trifoliate orange berry extract;S3, golden yellow chamomile raw material is chosen, 8 times 50% of ethyl alcohol is added, proper amount of sodium citrate is added and adjusts extraction The pH to 8 or so of liquid, room temperature extract 48 hours, the filtering of 1um filter paper obtains golden yellow camomile extract;S4, purslane is chosen 8 times of water are added in raw material, and Microwave Extraction 45 minutes, the filtering of 1um filter paper obtains Purslane extract;S5, by S1-S4 obtain 4 Plant Extracts, are compounded in proportion, obtain moisturizing Shu Min complex liquid.
1. experimental material
Instrument: Cornemeter CMB25 (German CK company)
Given the test agent: No. 1 (water), No. 2 (moisturizing Shu Min complex liquid-embodiment 1), No. 3 (moisturizing Shu Min complex liquids-implementation Example 2), No. 4 (moisturizing Shu Min complex liquid-embodiment 3), No. 5 (moisturizing Shu Min complex liquid-embodiment 4), No. 6 (moisturizing Shu Min is compound Liquid-embodiment 5)
2. experiment condition
1. indoor environment
2. without sunburst or light direct projection
3. 20 DEG C ± 2 DEG C of environment temperature, ambient humidity 40-60%
3. subject's condition
1. 18-60 years old age normal subjects, men and women, lady first
2. without serious systemic disease, without immune deficiency or autoimmune patient
3. no active anaphylactia person
4. previously to skin-care cosmetics without allergies
5. not being using hormone medicine and immunosuppressor entirely in nearly January
6. not participating in other clinical trial persons
7. aspiration participates in and can complete specified content person by requirement of experiment
8. the subject more than meeting is no less than 30 people
4. skin moisture content working principle
Using universally acknowledged Cornemeter method-capacitance method, its principle is based on the dielectric of water (81) and other substances Constant (< 7) variation is quite big, and according to the difference of water content, the measuring capacitor of suitable shape can be with the capacitance of skin Variation and change, and the capacitance of skin is can thus to measure the moisture content of skin in the range of measurement. The measurement method of capacitance is more superior than other methods, several due to being tested the skin contact not unnatural with test probe Without electric current by being tested skin, therefore test result is not influenced actually by polarity effect and ionic conductivity.Instrument Moisture, which is established, in device probe and skin does not have inertia in equilibrium process, rapid survey may be implemented, also eliminate work simultaneously in this way Influence of the property skin to measurement result.
5. testing procedure
1. test zone: hand inner forearm
2. preparing before test
White-skinned face function product (cosmetics, topical drug or health care product for oral administration) cannot be used within 2-3 days before recipient site, test Before, subject needs unified cleaning inner forearm, is wiped over completely with dry face tissue, is carried out after cleaning in subject's inner forearm Measured zone label, should sit quietly at least 30min before official testing in standard compliant room, forearm exposure, in test shape State is placed, and keeps light.
The Experimental Area 2 × 4cm2 of inner forearm label in experiment, same arm can mark multiple regions simultaneously, it is interregional every 2cm.Test product and blank control are randomly dispersed on hand forearm, first measure the blank of 30min after each test zone cleaning Then value is pressed 2.0 ± 0.1mg sample/cm2 dosage, test sample is spread evenly across in test block using latex finger cot, smear Measure the skin moisture content in 0.5h, 1h, 1.5h, 2h tested region and control zone respectively afterwards.The measurement of the same volunteer It is completed by the same survey crew.
6. test index
Skin moisture content measurement: measurement twice, takes mean value.
7. the form of control
It is compareed with two kinds of different disposals itself are carried out.8. statistical method
Carry out paired t-test
9. result and analysis
1. subparticipation tester's measurement result
2. analyzing
Moisturizing Shu Min complex liquid is evaluated in the experiment using crowd's skin moisture-keeping effect after 2h, 30 during use Volunteer has no the adverse reactions such as allergy.
After 2h on probation, analysis of experimental data is as follows,
Two-tailed test, t0.05 (4)=2.2776
1. number, d=7.32, Sd=4.26, t=3.87
2. number, d=3.28, Sd=2.52, t=2.93
3. number, d=5.16, Sd=3.15, t=3.69
4. number, d=5.08, Sd=3.72, t=3.07
Through statistical analysis, difference is statistically significant (P < 0.05), shows that No. 2 samples have moistening effect, i.e. moisturizing Shu Min complex liquid has moisture-keeping function, and above the data of record, and moistening effect is successively 1 > embodiment of embodiment 2 > implementation 3 > embodiment of example, 5 > embodiment 4
The test of Shu Min sexual function is carried out to embodiment:
Comprehensive 2 kinds of both effectiveness test results, we it can be concluded that, 5 embodiments all have the effect of moisturizing Shu Min, each side Face comprehensive reference is got off, final to determine that embodiment 3 is best proportion.
Formula addition case:
Formula as below is all based on test result above, adds as both effectiveness ingredient in recipe.
Case 1
Case 2
Case 3
Case 4
Case 5
Case 6
Case 7
Case 8
Case 9
The preferred embodiment of the present invention has shown and described in above description, as previously described, it should be understood that the present invention is not office Be limited to form disclosed herein, should not be regarded as an exclusion of other examples, and can be used for various other combinations, modification and Environment, and can be changed within that scope of the inventive concept describe herein by the above teachings or related fields of technology or knowledge It is dynamic.And changes and modifications made by those skilled in the art do not depart from the spirit and scope of the present invention, then it all should be appended by the present invention In scope of protection of the claims.

Claims (8)

1. a kind of moisturizing Shu Min complex liquid, it is characterised in that: including 2-10% dried tremella extract, 2-8% trifoliate orange berry extract, 1- 7% golden yellow camomile extract, 1-10% purslane extract, 20-30% butanediol, surplus are deionized water.
2. a kind of preparation method of moisturizing Shu Min complex liquid, it is characterised in that: tremella raw material S1, is chosen, 10-20 times of water is added, 95-100 DEG C of high temperature extracts 60-120min, filtered through gauze, and 65-75 DEG C of vacuum distillation filtered fluid is concentrated into filtrate is original 1/ 3, after being cooled to room temperature, the 50-70% ethyl alcohol of 2-5 times of filtrate quality is added, stirs 10-15 minutes, 1-2 hours static, filtering Retain filter residue, dry filter residue obtains dried tremella extract;S2, trifoliate orange fruit raw material is chosen, pulverizer crushes, 2-5 times of methanol is added, 50-60 DEG C refluxing extraction object 2-3 hours, the filtering of 1um filter paper, 60-70 DEG C of reduced pressure filtering to no methanol residual, moisture content 3% hereinafter, obtaining trifoliate orange berry extract;S3, golden yellow chamomile raw material is chosen, 5-10 times 50% of ethyl alcohol is added, be added Proper amount of sodium citrate adjusts the pH to 8 of extracting solution, and room temperature extracts 48 hours, the filtering of 1um filter paper obtains golden yellow chamomile and extracts Object;S4, purslane raw material is chosen, 5-10 times of water is added, Microwave Extraction 30-60 minutes, the filtering of 1um filter paper obtains purslane Extracting solution;S5, it is compounded in proportion by 4 Plant Extracts that S1-S4 is obtained according to composition of raw materials, obtains moisturizing Shu Min Complex liquid.
3. a kind of preparation method of moisturizing Shu Min complex liquid according to claim 2, which is characterized in that in the S1-S4 The water being added is deionized water, and the microwave power used in Microwave Extraction in the S4 is 50w/kg.
4. a kind of preparation method of moisturizing Shu Min complex liquid according to claim 2, which is characterized in that dry in the S1 Dry filter residue uses freeze-drying, and the freeze-drying uses one of vacuum freeze drying and microwave freeze-drying.
5. a kind of preparation method of moisturizing Shu Min complex liquid according to claim 4, which is characterized in that in the S1, very Vacuum freecing-dry temperature controls in -10 DEG C~-5 DEG C sections, in the container of high vacuum absolute pressure 10-133Pa, microwave freezing Drying is temperature to be first reduced to -25 DEG C, then carry out microwave drying in three stages, and microwave power is respectively 200w/kg, 400w/ Kg and 150w/kg, and the time ratio of microwave is 1:3:2 three times.
6. a kind of preparation method of moisturizing Shu Min complex liquid according to claim 2, which is characterized in that the gold in the S3 Yellow camomile extract mainly includes bisabolol.
7. a kind of preparation method of moisturizing Shu Min complex liquid according to claim 2, which is characterized in that compounded in the S5 Temperature control is at 20 DEG C ± 2 DEG C, ambient humidity 40-60% in the process, and the interior of without sunlight direct projection and light direct projection.
8. a kind of application of moisturizing Shu Min complex liquid according to claim 1, which is characterized in that living for moistening face centella Flesh essence dew, profit face lily isolating and protecting frost, the HERBA DENDROBII youth fix liquid, soapberry betaplex gentle cleansing milk, plant extraction skin-active it is salubrious Cream, nine grace plant the shining face liquid of extraction, water light Essence, the compact eye cream of dimension E victory peptide, profit face ginseng and shine and adopt in facial mask.
CN201910533891.XA 2019-06-19 2019-06-19 A kind of moisturizing Shu Min complex liquid and the preparation method and application thereof Pending CN110179709A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110522706A (en) * 2019-10-09 2019-12-03 上海高蒂雯药业有限公司 The compact Face-protecting mask liquid of the antiallergic of the leaf extract containing hemp, facial mask and preparation method thereof
CN110859785A (en) * 2019-12-02 2020-03-06 江苏巴帝恩生物科技有限公司 Preparation method and application of anti-allergy compound
CN115737505A (en) * 2022-12-08 2023-03-07 现代百朗德生物科技(江苏)有限公司 Populus alba bark toner powder with moisturizing and oil controlling effects and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105769654A (en) * 2016-03-02 2016-07-20 名臣健康用品股份有限公司 Anti-sensitivity skin-care composition and application thereof to cosmetics
CN109453083A (en) * 2018-12-13 2019-03-12 广州睿森生物科技有限公司 A kind of moisturizing is relaxed sensitive composition and its application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105769654A (en) * 2016-03-02 2016-07-20 名臣健康用品股份有限公司 Anti-sensitivity skin-care composition and application thereof to cosmetics
CN109453083A (en) * 2018-12-13 2019-03-12 广州睿森生物科技有限公司 A kind of moisturizing is relaxed sensitive composition and its application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
江苏霖轩网络科技有限公司: "To me 活性肽冻龄调理面膜", 《电子凭证-国产非特殊用途化妆品备案信息服务平台HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20170610093809E80ND&NID=20170610093809E80ND》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110522706A (en) * 2019-10-09 2019-12-03 上海高蒂雯药业有限公司 The compact Face-protecting mask liquid of the antiallergic of the leaf extract containing hemp, facial mask and preparation method thereof
CN110859785A (en) * 2019-12-02 2020-03-06 江苏巴帝恩生物科技有限公司 Preparation method and application of anti-allergy compound
CN115737505A (en) * 2022-12-08 2023-03-07 现代百朗德生物科技(江苏)有限公司 Populus alba bark toner powder with moisturizing and oil controlling effects and preparation method thereof

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