JPH10226617A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin preparation for external use that has excellent prevention of skin aging as moisture retention effect, prevention of skin roughening, roughening-improving effect, prevention and improvement of wrinkling by including an extract from a specific plant and an amino acid (salt thereof) in the composition. SOLUTION: A plant selected from hida arborvitae (Thujopsis dolabrata), Isodon japonicus and agrimony (Agrimonia pilosa), its whole grass, the whole leaves, barks, branches and the like is dried, when necessary crashed and subjected to an extraction treatment with a solvent (for example, ethyl alcohol) of by means of a Soxhlet extractor to collect the extract of hiba arborvitae, Isodon japonicus or agrimony (A). The component (A) in an amount of 0.001-20wt.% on the dried solid basis, (B) an amino acid, preferably a basic amino acid or its salt, for example, arginine in an amount of 0.001-20wt.% and (V), when necessary, medicinally effective components, oily medicine, surfactures, pH modifier and the like are formulated for prepare a medicinal skin proportion for external use, cosmetics and other type of skin preparations for external use.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which is excellent in skin aging prevention effects such as moisturizing the skin, preventing and improving rough skin, and preventing and improving wrinkle formation.

[0002]

2. Description of the Related Art In recent years, maintaining healthy and beautiful skin has become a serious concern for both young and old. However, the skin is delicately affected by aging, temperature, humidity, ultraviolet rays, cosmetics, disease, stress, eating habits, etc. Therefore, various functions of the skin (prevention of loss of moisture etc. from the living body, constant body temperature) Functions that control the maintenance of the body, physical and chemical stimulation from the outside world and the function of protecting the body from various bacteria, the function of maintaining the elasticity of the skin and determining the surface morphology, etc.), the aging of the skin, etc. Trouble occurs.

Further, as described above, skin troubles are caused by changes in the external environment (seasonal changes, ultraviolet rays, etc.), and changes in physiological functions due to aging and diseases, and the functions of skin tissues caused by factors inside and outside the body. In addition to abnormalities, they are caused by skin thickening, parakeratosis, and the like induced by these.

[0004] The main attempts to prevent and improve such skin troubles are to apply a synthetic or natural moisturizing component to prevent the skin from drying and to enhance the moisturizing ability of the skin.
Methods for improving the promotion of blood circulation by applying a blood circulation promoting agent have been made.

That is, free amino acids, organic acids, urea,
The use of humectants such as inorganic ions and polysaccharides such as hyaluronic acid, animal and plant extracts, vitamins and derivatives thereof, peptides, proteins, and medicated skin external preparations and cosmetics containing hydroxy acids, etc., causes the above skin troubles. Attempts have been made to prevent and improve

However, even if such a component is applied to the skin, its effect is low and temporary, and it does not essentially prevent or improve the above-mentioned skin troubles.

[0007] On the other hand, wrinkles, which are one of the skin problems, occur due to aging, drying, aging due to ultraviolet rays and the like.
That is, drying, changes in the surface morphology of the epidermis due to external physical and chemical stimuli such as ultraviolet rays and aging, disease, tissue degeneration in the dermis due to stress, etc., especially collagen fibers are greatly lost and dermis degeneration, Aging of the skin, such as due to a decrease in subcutaneous adipose tissue, mainly causes wrinkle relaxation and loss of elasticity.

Conventionally, various compositions and methods have been proposed for suppressing or treating wrinkles due to such an aging effect (JP-A-62-185005,
JP-A-62-502546, JP-A-2-7215
7, JP-A-2-288822, etc.). However, none of these exhibited a satisfactory wrinkle improving effect.

[0009]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a skin external preparation which is excellent in skin aging prevention effects such as moisturizing effects, prevention and improvement effects of rough skin, and prevention and improvement effects of wrinkle formation. It is in.

[0010]

Under such circumstances, the present inventors have conducted intensive studies. As a result, if a specific plant extract is used in combination with an amino acid or a salt thereof, the skin has an excellent effect of preventing skin aging. The present inventors have found that an external preparation can be obtained, and have completed the present invention.

That is, the present invention relates to the following components (A) and (B): (A) an extract of one or more plants selected from the group consisting of Asunaro, Hikikoshi and Agrimony, (B) an amino acid and a salt thereof And a skin external preparation containing one or more compounds selected from the group consisting of:

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The plant extract of the component (A) used in the present invention is obtained from a plant selected from the group consisting of Asunaro, Hikikoshi and Agrimony.

[0013] The extract of these plants is obtained by drying one or more parts of the whole plant of each plant or its leaves, bark, roots, branches, etc. (hereinafter referred to as "the original substance") or without drying. After pulverization, it can be obtained by extracting with a solvent at room temperature or under heating or by using an extraction device such as a Soxhlet extractor. Here, the solvent used is not particularly limited, for example, water; primary alcohols such as methyl alcohol and ethyl alcohol; propylene glycol;
Liquid polyhydric alcohols such as 1,3-butylene glycol;
Liquid fatty acid lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; known solvents such as ethyl ether and acetone; these solvents may be used alone or in combination of two or more. it can. Among them, the extraction solvent is ethyl alcohol,
1,3-butylene glycol is preferred.

As a specific example of a preferred extraction method from the drug substance, 100 g of dry pulverized material is added with 1000 ml of 50 v / v% ethanol, and extraction is performed for 3 days at room temperature with occasional stirring. The obtained extract is filtered, and the filtrate is allowed to stand at 5 ° C. for 3 days and then filtered again to obtain a supernatant. The plant extract obtained under the above-mentioned conditions may be used as it is as an extracted solution, but if necessary, may be used one which has been subjected to treatments such as concentration and filtration.

The plant extract of the component (A) can be used alone or in combination of two or more, and it is preferable to add 0.0001 to 20% by weight in the total composition in terms of dry solid content. Preferable, especially 0.0001 to 10% by weight, further 0.0
It is preferable to add 001 to 5% by weight because a higher effect of preventing skin aging can be obtained.

The amino acids or salts thereof of component (B) used in the present invention include, for example, ornithine, tryptophan, lysine, arginine, histidine, canavanine, glutamic acid, aspartic acid, serine, alanine, glycine, leucine, isoleucine, proline , Threonine, valine, methionine, cystine, cysteine, hydroxyproline, lysine, phenylalanine, tyrosine, hydroxylysine, trimethylglycine, sodium aspartate, potassium aspartate, magnesium aspartate, calcium aspartate, sodium glutamate, potassium glutamate, glutamate Magnesium, calcium glutamate, glutamate hydrochloride, cysteine hydrochloride, histidine hydrochloride,
Histidine acetate, histidine phosphate, lysine hydrochloride,
Lysine acetate, ornithine hydrochloride, orchithine acetate,
Tryptophan hydrochloride, arginine-glutamate,
Examples include ornithine-glutamate, lysine-glutamate, lysine-aspartate, ornithine-aspartate, ε-aminocaproic acid, and the like. Among these, arginine, lysine, hydroxylysine and histidine are more preferably used as basic amino acids, and arginine is particularly preferred.

The amino acid or salt thereof of the component (B) is preferably contained in the entire composition in an amount of 0.0001 to 15% by weight, more preferably 0.001 to 10% by weight, further preferably 0.01 to 8% by weight. It is preferable because it has an excellent effect of preventing skin aging.

The external preparation for skin of the present invention is roughly classified into a medicated external skin preparation and a cosmetic according to its form. Examples of the medicated skin external preparation include various ointments containing a pharmaceutically active ingredient. Here, the ointment may be any of those based on an oily base and those based on an oil / water or water / oil emulsion type base. The oleaginous base is not particularly limited, and examples thereof include vegetable oils, animal oils, synthetic oils, fatty acids, and natural or synthetic glycerides, ceramides, and pseudoceramides. Further, the medicinal component is not particularly limited, for example, an analgesic anti-inflammatory, an antipruritic,
A disinfectant, an astringent, an emollient, a hormonal agent, and the like can be appropriately used as needed.

The cosmetics may be in various forms, such as water / oil type emulsified cosmetics, oil / water type emulsified cosmetics, creams, emulsions, lotions, oily cosmetics, packs, lipsticks,
It can be used as a skin cosmetic such as a foundation, a skin cleanser, a hair tonic, a hair styling agent, a hair restorer, a hair restorer and the like. In the case of cosmetics, in addition to the above essential components, components that are blended in ordinary cosmetics within a range that does not impair the effects of the present invention, such as oils, surfactants, pH regulators, ceramides, and pseudoceramides , Moisturizers, sterols, alcohols, chelating agents, anti-inflammatory agents, singlet oxygen scavengers, antioxidants, ultraviolet absorbers, preservatives, thickeners, pigments, fragrances, etc., if necessary. be able to.

The oil agent used herein is not particularly limited. For example, isopropyl palmitate, butyl stearate, isopropyl myristate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-
3-myristoyl glycerol, cholesteryl isostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, neopentyl glycol di-2-ethylhexanoate, 2-octyldodecyl oleate Esters such as glycerol triisostearate, glyceryl di-paramethoxycinnamate-mono-2-ethylhexanoate;
2-hexyldecanol, oleyl alcohol, 2-octyldodecanol, patyl alcohol, cetanol,
Higher alcohols such as stearyl alcohol; hydrocarbons such as squalane, liquid paraffin, vaseline, and solid paraffin; eucalyptus oil, peppermint oil, olive oil, camellia oil, macadamia nut oil, jojoba oil, avocado oil, lanolin, tallow, lard, egg yolk And the like; and benzyl alcohol, phenylethyl alcohol, dextrin palmitate, various silicone derivatives, and the like.

Although the surfactant is not particularly limited, for example, polyoxyethylene (hereinafter abbreviated as POE)
Hydrogenated castor oil, POE alkyl ether, POE branched alkyl ether, POE fatty acid ester, POE glycerin fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE hardened castor oil alkyl sulfate, POE alkyl sulfate, polyglycerin fatty acid ester, Alkyl phosphate, POE alkyl phosphate, fatty acid alkali metal salt, sorbitan fatty acid ester, glycerin fatty acid ester, alkyl polyglucoside, polyethylene glycol fatty acid ester, α-monoisostearyl glyceryl ether, stearoyl methyl taurine sodium, POE lauryl ether phosphorus Sodium acid, ether-modified silicone, and the like.

The pH regulator is not particularly restricted but includes, for example, metal oxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine, diisopropanolamine, urea, sodium pyrrolidonecarboxylate, phosphorus Sodium oxyhydrogen,
Examples include sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid and the like. The external preparation for skin of the present invention is preferably adjusted to have a pH of 3 to 10 with these.

Ceramides are extracted from brain and skin,
It may be purified or synthesized by a chemical method. As such a synthesis method, for example, JP-A-59-7118, WO93 / 2281
The method described in the item can be used. Particularly preferred ceramides include N-oleoyl sphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, bovine brain ceramide and the like.

As pseudo-ceramides, for example, those described in
And those manufactured according to the methods described in JP-A-228048 and JP-A-63-216852. Particularly preferred as pseudo-ceramides are the following formula (1)

[0025]

Embedded image

(Wherein R ¹ represents an alkyl group having 9 to 17 carbon atoms, and R ² represents an alkyl group having 10 to 18 carbon atoms).

The sterols include cholesterol and cholesterol derivatives. Examples of the cholesterol derivatives include cholesteryl alkenylsuccinate, cholestanol, C12-36, preferably C14.
And cholesteryl esters having up to 28 saturated or unsaturated linear or branched hydrocarbon groups, and dehydrocholesterol. Among them, cholesteryl alkenyl succinate includes those synthesized by the production method described in JP-A-5-294989, for example, cholesteryl monoester n-hexadecenyl succinate, cholesteryl n-octadecenyl succinate. Monoester and the like. Examples of cholesteryl esters include cholesteryl isostearate, cholesteryl 1,2-hydroxystearate, dehydrocholesterol, lanolin fatty acid cholesteryl, cholesteryl ricinoleate, and the like. Of these, cholesteryl alkenyl succinate and cholesterol are preferred. These sterols may be used alone or in combination of two or more.

The alcohol is not particularly restricted but includes, for example, lower alcohols such as ethanol; higher alcohols such as cetanol, stearyl alcohol and octyldodecanol; and polyhydric alcohols such as ethylene glycol, diethylene glycol, triethylene glycol and more. Polyethylene glycols, propylene glycol, dipropylene glycol, more polypropylene glycols, 1,3-butylene glycol, butylene glycols such as 1,4-butylene glycol, glycerin, diglycerin, more polyglycerols, Sorbitol, mannitol, xylitol, sugar alcohols such as maltitol, glycerin ethylene oxide (hereinafter abbreviated as EO), propylene oxide (hereinafter PO) Abbreviations) adducts, EO and PO adducts of sugar alcohols, monosaccharides such as galactose and fructose, and polysaccharides such as EO, PO adducts, maltose and lactose and their EO and PO adducts, and polyoxyethylene methyl And polyoxyalkylene alkyl glycosides such as glucoside (EO 10 or more).

Examples of the anti-inflammatory agent include glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, allantoin, lysozyme chloride, guaiazulene, methyl salicylate, γ-oryzanol and the like.
Epsilon aminocaproic acid is preferred.

As the singlet oxygen scavenger or antioxidant,
For example, carotenoids such as α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin, inzeaxanthin, rhodoxanthin, capsanthin, crocetin; 1,4-diazadiclooctane, 2,5-dimethylfuran , 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol or its alkyl ester, dibutylhydroxytoluene, butylhydroxyanisole, ascorbin Tannins such as acid, tannic acid, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate; and flavonoids such as rutin. Of these, carotene, tocopherol, ascorbic acid, tannic acid, dibutylhydroxytoluene, alanine, rutin, epicatechin gallate, and epigallocatechin gallate are preferred.

The external preparation for skin of the present invention can be produced by mixing the components (A) and (B) and optional components according to a conventional method.

[0032]

The external preparation for skin of the present invention synergistically uses a plant extract of the component (A) and an amino acid or a salt thereof of the component (B) to provide a synergistic moisturizing effect and prevent / improve skin roughness. The effect of preventing and improving wrinkles and wrinkles is enhanced, and the effect of preventing skin aging is excellent.

[0033]

The present invention will be further described with reference to the following examples, but the present invention is not limited to these examples.

Production Example 1 (Production of Asunaro Extract)
1000 ml of 0 v / v% ethanol was added, and extraction was performed for 3 days at room temperature with occasional stirring. The obtained extract was filtered, and the filtrate was allowed to stand at 5 ° C. for 3 days and then filtered again to obtain a supernatant.

Production Example 2 (Production of Hioki Sorghum Extract) In Production Example 1, instead of the dried and crushed asnaro,
The production was carried out in the same manner as in Production Example 1 except that a dry ground product of the above-ground part of Hioki-koshi was used.

Production Example 3 (Production of an extract of Agrimony) In Production Example 1, instead of the dried and crushed asnaro,
It was produced in the same manner as in Production Example 1 except that a dried and ground product of the above-ground part of Agrimony was used.

These extracts have a dry solid content of 0.1
It shall be manufactured so that it may become ~ 20%.

Example 1 An O / W cream having the composition shown in Table 3 was produced by the following method, and the resulting cream was evaluated for skin conductance, skin roughness score, and wrinkle-suppressing effect when this cream was used. Table 4 shows the results.

(Production method) Oil phase components [(1), (2),
(4) to (9), (13), and (14)] were heated and dissolved at 80 ° C., and the aqueous phase components [(3), (11), (12), (17)-(1)
9) and (21)], and the mixture was emulsified, and then stirred and cooled to 50 ° C. Then, the components (10), (15) and (16)
And (20) were added, and the mixture was cooled to room temperature with further stirring to obtain an O / W cream.

(Test Method) Ten women, aged 20 to 50, having rough skin on their cheeks in winter, were subjected to different skin external preparations on their left and right cheeks for two weeks. The test was performed on the day after the two-week application was completed for the skin conductance and the skin roughness score.

(1) Skin conductance: After washing the face with warm water of 37 ° C. and resting in a room at a temperature of 20 ° C. and a humidity of 40% for 20 minutes, the water content of the stratum corneum was measured by a skin conductance meter (IBS). Was measured. As the skin conductance value becomes smaller, the skin becomes rougher. The results were shown as average values.

(2) Roughness score: Roughness was observed with the naked eye and judged according to the following criteria. The score was shown as an average value.

[0043]

[Table 1] Score 0: No rough skin is observed. 1: Slight roughness is recognized. 2: Skin roughness is recognized. 3: Severe rough skin is recognized. 4: Severe rough skin is recognized.

(3) Wrinkle formation inhibitory effect: (Evaluation method) An external preparation for skin (80 μm) was applied to a hairless mouse.
l) was applied. UV-B after 2 hours (1 MED or less)
, And immediately after that, a further sample was applied. This operation was performed five times a week for 16 weeks. Irradiation energy amount is UV-Radiometer (Tokyo op
Tal., VU-R-305 / 365 days), and measured so that the irradiation amount at one time is 1 MED or less.
The total irradiation amount was 100 mJ / cm ² with an energy amount of 8 mW / cm ² . After the application / irradiation for 16 weeks was completed, the frequency of the formed wrinkles was visually evaluated according to the following criteria (wrinkle index).
The results are shown as the average of 10 hairless mice.

[0045]

Table 2 Criteria (wrinkle index) 1: No wrinkles formed. 2: Wrinkles are slightly formed. 3: Some wrinkles are formed. 4: Wrinkles are firmly formed.

[0046]

[Table 3]

* 1: Pseudoceramide N- (2-hydroxy-3-hexadecyloxypropyl) -N-2-hydroxyethylhexadecanamide [In the general formula (1), R ¹ = C ₁₅ H ₃₁ , R ² = C ₁₆ H ₃₃ ] * 2: Silicone KF-96A (6cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) * 3: Asnaro extract (Production Example 1: dry solid content 1.0
%) * 4: Hikikoshi extract (Production Example 2: dry solid content 1.2)
%)

[0048]

[Table 4]

Example 2 A sunscreen cream having the following composition was produced by the following method. The obtained cream was excellent in the effect of preventing skin aging.

[0050]

(Composition) (% by weight) (1) Pseudoceramide ^{* 7} 3.0 (2) Silicon-coated zinc oxide 7.0 (3) 2-Ethylhexyl p-methoxycinnamate 2.0 (4) Vitamin E Acetate 0.2 (5) Cholesteryl isostearate 1.5 (6) Polyether-modified silicone ^{* 8} 2.5 (7) Methylpolysiloxane ^{* 9} 6.0 (8) Cyclic silicone ^{* 10} 12.0 (9) Magnesium sulfate 0.7 (10) Acidic polysaccharides ^{* 11} 5.0 (11) Glycerin 3.0 (12) Asnalo extract ^{* 12} 1.0 (13) Arginine 0.5 (14) Preservatives Appropriate amount (15) Purified water Remaining amount * 7: N- (2-hydroxy-3-hexadecyloxypropyl) -N-2-hydroxyethylhexadecanamide [In the general formula (1), R ¹ = C ₁₅ H ₃₁ , R ² = C ₁₆ H _33] * 8: silicone KF-6015 (Shin-Etsu of * 9: Silicone KF-96A (6cs) (Shin-Etsu Chemical Co., Ltd.) * 10: Silicone SH-244, SH-245 or a 3: 2 (weight ratio) mixture of SH-244 and SH-245. (Manufactured by Toray Dow Corning Silicone Co., Ltd.) * 11: Acidic heteropolysaccharide derived from tuber callus produced according to Example 1 of JP-A-64-10997 * 12: Asnaro extract (Production Example 1) : Dry solid content 1.0%)

(Production method) Oil phase component [(1), (3) to
(6)] was heated to 80 ° C. to dissolve it, and the aqueous phase components [(9) to (15)] were added thereto, mixed uniformly, and stirred and cooled to 50 ° C., after which components (2) and ( 7) and (8) were uniformly mixed to obtain a sunscreen cream.

Example 3 A moisturizing essence having the following composition was produced by the following method. The obtained moisturizing essence was excellent in skin aging prevention effect.

[0053]

(Composition) (% by weight) (1) Polyoxyethylene (40) hydrogenated castor oil 1.0 (2) Acidic polysaccharide ^{* 13} 1.0 (3) Urea 1.0 (4) Monophosphate Sodium hydrogen 0.75 (5) Citric acid 0.25 (6) Glycerin 10.0 (7) Ethanol 4.0 (8) Carboxyvinyl polymer ^{* 14} 1.5 (9) Potassium hydroxide 0.45 (10) Asnaro extract ^{* 12} 1.0 (11) Histidine 0.5 (12) Preservative appropriate amount (13) Purified water balance * 13: Tuberobe produced according to Example 1 of JP-A-64-10997 * 14: Carbopol 981 (manufactured by BF Goodrich Chemical) * 15: Button extract (Production Example 2: dry solid content 1.0%)

(Preparation method) Components (1) to (8) and (11)
To (13) are uniformly stirred and dissolved, and the component (9) is added and uniformly dispersed. Further, the component (10) was added to obtain a moisturizing essence.

Example 4 An oily foundation cream having the following composition was produced. The obtained foundation cream was excellent in the effect of preventing skin aging.

[0056]

(1) Pseudoceramide ^{* 16} 3.0 (2) Silicon-coated zinc 5.0 (3) 2-Ethylhexyl p-methoxycinnamate 3.0 (4) Cholesteryl isostear Rate 3.0 (5) Polyether-modified silicone ^{* 17} 3.0 (6) Methylpolysiloxane ^{* 18} 5.0 (7) Cyclic silicone ^{* 19} 10.0 (8) Neopentyl glycol dicaprate 2.0 (9 ) Glycerin 2.0 (10) Titanium oxide 3.0 (11) Sericite 2.0 (12) Talc 3.0 (13) Bengala 0.05 (14) Yellow iron oxide 0.10 (15) Black iron oxide 0.05 (16) Chrysanthemum extract ^{* 20} 1.0 (17) Goldfinch extract ^{* 21} 1.0 (18) Arginine 0.5 (19) Preservative appropriate amount (20) Flavor appropriate amount (21) Purified water * 16: N- (2-hydroxy-3-hexadecyloxy) Propyl) -N-2-hydroxycarboxylic ethyl hexadecanol cyanamide [general formula ^{(1), R 1 = C} 15 H 31, R 2 = C 16 H 33 ] * 17: Silicone KF-6015 (Shin-Etsu Chemical Co. * 18: Silicone KF-96A (6cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) * 19: Silicone SH-244, SH-245 or a 3: 2 (weight ratio) mixture of SH-244 and SH-245 ( Toray Dow Corning Silicone Co., Ltd.) * 20: Hikikoshi extract (Production Example 2: dry solid content: 1.2%) * 21: Goldfish extract (Production Example 3: dry solid content: 1.1%)

(Production method) Oil phase components [(1) to (6),
(8)] was heated and dissolved at 80 ° C., and the aqueous phase component [(9), (18), (1) was heated to 80 ° C. while stirring.
9) and (21)], and emulsified. The mixture was stirred and cooled to 50 ° C., and then the components (7), (10) to (17) and (2)
0) was added, and the mixture was cooled to room temperature with further stirring to obtain an oily foundation cream.

Example 5 An O / W type moisturizing emulsion having the following composition was produced by a conventional method. The obtained O / W type moisturizing emulsion was excellent in the effect of preventing skin aging.

[0059]

(Table 8) (Composition) (% by weight) (1) Pseudoceramide ^{* 16} 3.0 (2) Asnaro extract ^{* 12} 0.5 (3) Arginine 0.5 (4) Cetyl alcohol 1.0 (5) Vaseline 2.0 (6) Squalane 5.0 (7) Dimethylpolysiloxane (6 cSt) 2.0 (8) Glycerin 4.0 (9) 1,3-butylene glycol 2.0 (10) Polyoxyethylene (20 ) Sorbitan monooleate 0.5 (11) Sorbitan monostearate 0.3 (12) Acidic polysaccharide ^{* 11} 5.0 (13) Cholesteryl monoester n-hexadecenyl succinate 1.0 (14) Glycyrrhetin Stearyl acid 1.0 (15) Tocopherol 1.0 (16) Succinic acid 0.55 (17) Sodium dihydrogen phosphate 0.9 (18) Purified water

(Production method) Components (1), (4) to (7),
(10), (11) and (13) to (15) were dissolved by heating to 80 ° C., and the aqueous phase components [(2), (3),
(8), (9), (12), (16) to (18)] were added and mixed uniformly, and cooled to room temperature to obtain an O / W type moisturizing emulsion.

Claims (3)

[Claims] 1. The following components (A) and (B): (A) an extract of one or more plants selected from Asunaro, Hikikoshi and Agrimony; (B) 1 selected from amino acids and salts thereof. An external preparation for skin containing one or more compounds. 2. The external preparation for skin according to claim 1, wherein the component (A) is an asnalo extract. 3. The external preparation for skin according to claim 1, wherein the component (B) is one or more selected from basic amino acids.