KR100702176B1 - Low stimulative cosmetic composition - Google Patents

Abstract

The present invention relates to a cosmetic composition having gomari, henna, and baekhwasasulcho extracts contained in the liposomes and stabilized so as to easily penetrate into the human body, exhibit excellent irritation-reducing effects, and have very stable scalp and hair improvement effects. Liposomes containing Gomari, henna and chlorosis are contained in an amount of 0.01 to 20.0% by weight based on the total weight of a conventional cosmetic composition.

Gomari, henna, birch, cosmetics, liposomes,

Description

LOW STIMULATIVE COSMETIC COMPOSITION

The present invention relates to a cosmetic composition having a gomari, henna, baekrye sagechocho extract contained in the liposomes and stabilized, so as to easily penetrate into the human body, exhibit an excellent irritant effect, and have a very stable scalp and hair improving effect.

The skin of people living in a muddy air is exposed to various harmful environments and stresses from outside and suffers various damages.As ages, the physiological activity of the skin organs decreases and the recovery rate of damaged skin slows down. Various skin aging phenomena such as decreased elasticity, wrinkle formation, and hair loss are met. In addition, due to the irradiation of ultraviolet rays from the sun, the development of cosmetics having a therapeutic function in the concept of simple clean beautification is required.

In order to overcome this problem, various methods are required to develop a cosmetic treatment concept for treating hair damage for hair cosmetics such as various styling, treatment shampoos, rinses and hair dyes.

Minoxidil, an alopecia treatment drug developed by Pharmacia & Upjohn of the United States, recently approved by the FDA as a drug to promote hair regrowth, has the chemical name 6- (1-piperidinyl) -2,4-pyrimidinediamine-3 Called an oxide, it is described in US Pat. No. 4,139,619 as a hair regrowth agent. The drug type is Vasodilator, Potassium (K +) channel opener. It was originally used to treat hypertension, which acts as a smooth muscle vasodilator.

This is a medicine that is applied to the young, oily, and if the part of the kiln falls to some extent (20 ~ 30%), but other than that does not show a very good effect. However, like Propecia (Propecia), there is a problem of side effects, and in terms of effectiveness, there is no clear effect so far, such as the use of several times daily.

In addition, hair loss containing ginseng extract, hair growth agent (JP-A-7-267830), (JP-A-7-277930), (JP-A-5-5851), hair loss prevention and containing ginseng extract and Although research on the mechanism of action such as 5 alpha-reductase inhibitor (Korean Patent Publication No. 10-0311199) has been reported, there is no clear effect.

In addition, as a new use of acetylsalicylic acid, ointments for the treatment of neuralgia (Japanese Patent Publication A3-72426), external preparations for the treatment of skin damage (Japanese Patent Publication A9-235232), pruritus treatment external preparations (International Publication No. WO 2001/47525) No.), an external preparation for the treatment of allergic dermatitis (WO 2001/47526), a composition having an improvement effect on the scalp and hair containing acetylsalicylic acid is being studied.

One or more hydrogens in the cationium salt are substituted by alkyl group among the hair cosmetic treatments currently used. CATIONIC SAA, CATIONIC POLYMER manufactured by attaching quaternized FATTY ALKYL group to modified polymer, compounds of silicones, The reality is that chemicals such as animal-derived proteins or substances of animal origin are mainly used.

A new extraction method is being developed to replace the existing extraction method using organic materials. Among these methods, a method of applying supercritical fluid technology to natural product extraction has been tried as an extraction method applicable to the human body by minimizing the toxicity of residual substances. .

Supercritical fluids generally exist above critical temperatures and pressures, and have a low viscosity and high mass transfer ability due to the intermediate nature of gases and liquids.

Representative supercritical fluids include carbon dioxide, which are widely used because they have advantages such as nontoxic environmental friendliness at low critical temperatures and pressures (supercritical extraction (SFE) and solvent extraction of β-ecdysone in the dew) , Journal of the Korean Society of Agricultural Chemistry and Biotechmology Vol. 44 (3) pp.197-201, 2001, Shim, Jae-Hwan / Soil Residue Analysis of Quinclorac in HPLC by Supercritical Extraction and Fluorescent Derivatives, Journal of the Korean Agricultural chemistry and biotechnology Vol.40 (5) pp.442-446, 1997, Yong-Hwan Kim / Extraction of Phenol Substances in Ginkgo Biloba Leaves by Supercritical Extraction, Journal of Pharmacognosy Vol.25 No.1 [1994] 85-86, Hur Hoon) .

In addition, liposomes (liposome) is a special kind of liposomes used in the drug delivery system, and is widely used not only in the pharmaceutical field but also in cosmetics and food. This has the advantage that the bioactive component can be stably delivered in an unbroken state and can be contained whether the bioactive component is fat-soluble or water-soluble.

Liposomes are largely divided into MLV (Multilamella vesicle) and monolithic liposomes (ULV: Unilamella vesicle), and ULV can be divided into Large Unilamella vesicle and Small Uni lame lla vesicle. MLV is 400-3500 nm in size and 5-15% of the amount can be contained in liposomes. LUV has a size of 100-1,000 nm, 36-65% of the amount can be contained in liposomes, and SLV has a size of 20-50 nm, and 0.5-1.0% of the amount can be contained in liposomes. The amount of bioactive substances that can be contained is the most LUV but unstable, SLV is the most stable but the amount that can contain less. In addition, the structure of the human skin has a multi-layered structure, so MLV has affinity with the skin, but its size is so large that it is difficult to penetrate the skin.

In contrast, liposomes are 10-50 nm in size and, in their components, unlike liposomes composed of phospholipids, ceramide, cerebromide, glycolipid, sphingomyelin Sphingolipid derivatives such as and the like to form a vehicle (Vesicle) and the inclusion of a bioactive component in the vehicle to penetrate the foot and excellent deposition.

The present invention has a moisturizing effect, prevents cracking effect, softening effect, inhibits overproduction of sebum associated with alopecia, prevents hair loss and has a strong antimicrobial effect against hair growth, skin epithelial bacteria in the scalp and at the same time helps hair growth. Its purpose is to obtain cosmetics that have the effect of improving the scalp and hair and relieving skin irritation, with the effect of thickening and strengthening the thin and weak hair.

The cosmetic composition of the present invention for achieving this purpose is characterized in that it comprises 0.01 ~ 20% by weight based on liposomes, Gomari, henna, baekryamsaeng extract.

In addition, the liposomes containing the Gomari, henna and baekryeoksacho supercritical extract are 0.01 to 20.0% by weight, based on the total weight of compositions such as conventional hair dye cosmetics, skin type cosmetics, lotion type cosmetics, essence type cosmetics, cream type cosmetics, and the like. It is characterized by containing.

A description of Gomari, henna, baekryeoksaeng which is a natural material used in the cosmetic composition of the present invention having the above characteristics is as follows.

Persicaria thunbergii H Gross is a vine of early years belonging to Polygo naceae.It is distributed mainly in Northeast Asia such as Korea and China, and it is mainly used for the treatment of hemostasis, rheumatism and measles. (Lee Chang-bok: Korea Plant Book 1986, Lee Woo-cheol: Primary Korea Plant Book 1996). In addition, the seeds are called high school vein, especially used for increasing vision and dysentery.

The components of the gomari are known as flavonoids such as persicarin and quercitrin (Chinese medicine dictionary, Shanghai Science and Technology Publishing House, 1996). In the present invention, the above-mentioned gomari using an extract extracted using a conventional extraction solvent.

Henna (Lawsonia inermis) is a tropical shrub that grows about 1 to 3 meters in Southwest Asia, such as Pakistan and India. In the Middle East, henna has been used for dressing ceremonies since the Stone Age. In modern times, it is used for hair dyeing and hair protection as well as facial makeup and tattoos.

The main component of henna is Lawsone (2-Hydroxy-1,4-naphthoquinone), which has the property of binding to human protein and Tannin has the property of browning, which destroys and penetrates the melanin pigment of hair of other chemical colorants. Unlike dyeing, there is little genetic damage to the human body and it can be used for tattoos and makeup. In addition, it has been used as a medicine for healing wounds and lowering heat, and it is known to inhibit the propagation of bacteria that grow on the scalp due to its antibacterial effect. (An assessment of the genotoxicity of 2-hydroxy-1,4-naphthoquinone, the natural dye ingredient of Henna.David Kirkland, Daniel Marzin, Mutation Research 537 (2003) 183199). In addition, Lawsone, a natural vegetable protein, can be combined with keratin, the main ingredient of hair, to form a protective outer layer to protect hair.

Many studies on SKIN IRRITATION of lawsone (2-Hydroxy-1,4-naphthoquinone) are known (Acute allergic contact dermatitis due to para-phenylenediamine after temporary henna painting.J Dermatol. 2003 Nov; 30 (11): 797- 800 Nawaf AM, Joshi A, Nour-Eldin O).

Baekhwasaolcho is an outpost of the annual herbaceous herb (Oldenlandiea diffusae ROXB.), Which belongs to the Rubiaceae family, and grows at the foot of a humid mountain. In China, Fujian, Guangdong, Guangxi, Yunnan and the south of the Yangtze River It is distributed mainly in Baekunsan and Jeju-do, Jeonnam, and is currently cultivated in Jinju (primary clinic of primary color, Yeonglimsa 1986, Korea Plant Book. Hyangmunsa 1982).

The pharmacological action of P. aeruginosa is antimicrobial activity against Staphylococcus aureus, hematopoiesis, etc. in vitro, promotes reticulum endothelial system and leukocyte phagocytosis, and to cells such as acute lymphocytes, granulocytes, monocytes and chronic granulocytes It is known to have a strong inhibitory effect (Jiangsu New Medicine: The Chinese Embassy, Shanghai Science and Technology Press, 754, 1979).

In addition, it has anti-cancer effects against human leukemia and liver cancer cells in vitro and against in vivo Walker-256, cervical carcinoma 14, sarcoma-180 and hepatocarcinoma. It is known (life-savings etc. port kind main walk, business secretary, 20. 1990). It is also known to have a protective effect of several methanol supercritical extracts on radioactive wound healing (Yakugaku Zasshi. 1990 Nov; 110 (11): 885-9. Japanese).

Heteroacontane, stigmasterol, ursolic acid, oleanolic acid, β-sitosterol, β-sitosterol-d-glucoside , p-coumaric acid, etc. (Chinese medicinal dictionary, Shanghai Science and Technology Press. 1979. Meng Yanfa et al, Lanzhou Univ, Tongbao 26 (4), 113-116. 1990), the new Irido Oldenlando-sides have been isolated as irridoids (Huang Jai Tung, Arch pharmach. 1981).

The method of preparing Gomari, henna, baekryeoksacho supercritical extract used in the present invention is as follows.

In order to prepare a supercritical extract, first dry the Gomari, henna, baekhwasaekcho and then pulverized to prepare a powder.

As the extraction solvent, polyhydric alcohols such as isopropyl alcohol, propylene glycol, butylene glycol, and the like can be used, and 1,3-butylene glycol and ethanol are mixed in the same mass ratio, followed by stirring to form a single phase and co-solvent. It is preferable to use as.

Supercritical fluid extraction used in the present invention can be carried out by a conventional method using carbon dioxide, specifically, it is preferably carried out as follows.

The crushed gomari, henna, and chlorosis are mixed with a cosolvent and stirred. The mixing ratio is a mass ratio of crushed gomari, henna, chlorosis and cosolvents in the range of 1: 2.5 to 6.5, preferably using a mass ratio of 1: 4 is the best in terms of yield. Subsequently, the mixture is introduced into a supercritical extraction tank, and the carbon dioxide is supplied to the extraction tank using a high pressure gas pump to increase the pressure.

Then, the temperature inside the extraction tank is raised to 40 ° C. and maintained therein. Then, while continuously supplying carbon dioxide to the extraction tank, the extract is released using a pressure regulator attached to the outlet side.

By controlling the temperature of the pressure regulator, the pressure and temperature drop of the discharge prevent carbon dioxide from transferring to solid dry ice and clogging the tube at the final outlet. As for this temperature, about 60 degreeC is preferable. The released extract is decompressed to atmospheric pressure to separate carbon dioxide and mushroom extracts, carbon dioxide is released into the atmosphere, and gomari, henna, and chlorosis supercritical extracts are recovered. The process may be repeated several times to increase the yield of the extract.

As liposomes for stabilizing the supercritical extract, liposomes prepared to have a closed bilayer structure having easy penetration into the skin, containing excess water-soluble components, and having a size of 10 to 50 nm, were selected.

In order to contain the Gomari, henna, and Bleached Supercritical extracts in liposomes, the components of liposomes are warmed and uniformly dissolved to obtain liposomes. Pass through a microfludizer.

Through the above process, by effectively stabilizing Gomari, henna, Baekhwasaeng supercritical extract, which is an active ingredient in the closed double layer structure of liposomes, the effect of Gomari, Henna, Baekhwasagul supercritical extract can be maximized.

Gomari, henna, chlorophyll extract supercritical extract, it is preferably included 0.01 to 20.0% by weight, particularly preferably 10.0% by weight relative to the total weight of liposomes containing it. When the content is less than 0.01% by weight, the effect is insignificant, and when the content is more than 20% by weight, the synergy is not sufficient.

The liposomes can be used for easy skin penetration and can contain an excessive amount of water-soluble components, especially stable non-ionic surfactants, co-emulsifiers, sphingolipid derivatives, cholesterol, cholesteryl esters and soysterol (Soy sterol) It is preferable to use liposomes prepared to have a closed double layer structure by high pressure emulsification using a mixture.

It is preferable to use polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, saccharose diester, etc. as said nonionic surfactant. It is preferable to contain a nonionic surfactant in the quantity of 10-50 weight% with respect to the total weight of a liposome, and it is especially preferable to contain 30-40 weight%.

It is preferable to use diglycerol as co-emulsifier, it is preferable to contain 1-50 weight% with respect to the total weight of a liposome, and it is especially preferable to contain 2-10 weight%.

The sphingolipid derivative, cholesterol, cholesteryl ester and soysterol are preferably contained in an amount of 30 to 80% by weight, particularly preferably 50 to 70% by weight, based on the total weight of the liposome. At this time, the cholesteryl nonanoate (Cholesteryl nonanoate), cholesteryl stearate (Cholesteryl stearate), cholesteryl isostearate (Cholesteryl isostearate), cholesteryl oleate (cholesteryl oleate) Preference is given to using steryl isostearyl carbonate, glyco lipids and the like.

In addition, in order to reinforce the role of lipids of the skin on the non-ionic surfactant, it is more preferable to bind the ceramide or phosphate derivative to the glycerin skeleton to have amphiphilic properties so as to be similar to the natural lipid component.

The ceramide used at this time is preferably contained in an amount of 0.1 to 10% by weight relative to the total weight of the liposome, and particularly preferably 2.0 to 6.0% by weight. Liposomes containing Gomari, henna, and baekryeosa supercritical extract prepared as described above are added to a conventional cosmetic composition to prepare cosmetics. The preparation examples are shown in the following Formulation Examples 1 to 7.

When cosmetics are prepared by adding Gomari, henna, and chlorophyll extract supercritical extract and containing liposomes to the cosmetic composition, it is preferable to contain it in an amount of 0.01 to 20.0% by weight based on the total weight of the cosmetic composition.

The cosmetic composition of this invention is not specifically limited in the formulation. For example, it is especially possible for hair products such as hair packs, hair rinses, hair lotions, hair dyes and the like. In addition, it can be appropriately selected and blended by those skilled in the art according to the formulation or purpose of use of Gomari, henna, chlorophyll extract supercritical extract and cosmetics.

The production examples, comparative production examples, and test examples described below are for explaining the present invention in more detail, and the scope of the present invention is not limited thereto.

(Manufacture example 1)

Preparation of Gomari, Henna, and Pale Lichen Extracts

Mix equal amounts of Gomari, henna and birches with 1: 1 by weight, dry them in a cool place without sunlight to grind weight, and grind 400g mechanically. It was.

As an extractant, 400 g of Gomari, henna, and chlorosis powder were added to a mixture of ethanol, 1.3-butylene glycol, propylene glycol, and distilled water (volume ratio 25: 25: 25: 25), and ultra-high frequency (Sonification) for 24 hours while boiling at 85 ° C for 48 hours. ), And filtered through a 200 mesh filter cloth and centrifuged at 3000 rpm for 10 minutes to separate the filtrate 500g. Then, the separated filtrate was used as a sample by sterile filtration with a 0.45㎛ filter.

(Manufacture example 2)

Preparation of Gomari, Henna, and Pear Blossom Supercritical Extracts

In order to prepare a supercritical extract, first, dried Gomari, henna and white chlorosis powder, and then pulverized to prepare Gomari, henna, white chlorosis powder.

Supercritical fluid extraction was performed by a conventional method using carbon dioxide, specifically as follows.

1000 g of crushed gomari, henna, and chlorosis are mixed with 4000 g of cosolvent and stirred. Subsequently, the mixture is introduced into a supercritical extraction tank, and carbon dioxide is supplied to the extraction tank using a high pressure gas pump to increase the pressure. Then, the temperature inside the extraction tank is raised to 40 ° C. and maintained therein. Thereafter, while continuously supplying carbon dioxide to the extraction tank, the extract is released using a pressure regulator attached to the outlet side. The temperature of the pressure regulator is controlled to prevent carbon dioxide from being transferred to solid dry ice due to the pressure and temperature drop of the emitters to block the tube at the final outlet. This temperature was 60 degreeC.

The released extract was decompressed to atmospheric pressure to separate carbon dioxide and Gomari, henna, baekrye sachocho supercritical extract, and to increase the yield of the extract was repeated two times to obtain a supercritical extract of 20g.

(Manufacture example 3)

Preparation of Liposomes Containing Gomari, Henna, and Bacteria Supercritical Extracts

1) The phase A is heated to 90 ° C. as shown in Table 1 below, mixed and dissolved uniformly.

2) The above 1) is cooled to 45 ° C., B phase is mixed, and then passed through a high pressure emulsifier (Microfludizer) three times under a pressure condition of 1000 bar.

ingredient weight% A Polyoxyethylene alkyl ether saccharose diester Polyoxyethylene alkyl ester cholesterol cholesteryl nonanoate soysterol ceramide diglycerol glycolipide 15.0 20.0 5.0 20.0 10.0 5.0 5.0 5.0 2.0 B Gomari, Henna, Bleached Supercritical Extracts 5.0 system 100

In the present invention, the particles have a size of 10 to 50 nm and are stable while being able to contain excessive amounts of water-soluble components.

(Comparative Production Example 1)

Preparation of Liposomes

Liposomes were prepared in the same manner as in Preparation Example 3, except that phase B of Table 1 was not added.

In vitro and iv vivo tests were measured by the following method in order to evaluate the effect of the cosmetics containing liposomes stabilized in Gomari, henna, baekrye sachocho supercritical extract according to the present invention.

In vitro test

(Test Example 1)

Percutaneous Permeability Measurement of Liposomes Containing Gomari, Henna, and Pear Blossom

DE (Dermal Equivalent; 1x105 cells / ml) of human normal fibroblasts, 3mg / ml collagen aqueous solution: 5X DMEM: 2.2% sodium bicarbonate and 200mM Hepes buffer in collagen gel structure similar to fibrous tissue Inoculated into a medium mixed with 0.05 N sodium hydroxide at 7: 2: 1 and incubated at 5% CO2 for 7 days at 37 DEG C). Inoculate 1x105 cells / ml of epidermal Keratinocytes on the surface of the DE where the fibroblasts were cultured, and inject K-SFM medium containing EGF and BPE inside and outside. Incubated for days.

Subsequently, the medium inside the plate was removed to allow air to come into contact with the surface of the cultured cells, followed by incubating for 2 weeks in a medium in which K-SFM containing 10% FBS and DMEM without EGF were mixed in the same amount. , Artificial skin with multilayer epidermis and dermis was obtained. Here, Preparation Example 1 and Comparative Preparation Examples 1 to 3 of the present invention were applied to the artificial skin tissue of the top layer. After 4 hours of incubation, the amount of complex supercritical extract that passed through the epidermis and dermis of artificial skin in the same amount of K-SFM containing 10% FBS and DMEM without EGF was analyzed by HPLC. It was. The test results are shown in the following [Table 2].

Penetration amount of complex extract (㎍ / ㎖) Preparation Example 1 0.3 Preparation Example 2 1.2 Preparation Example 3 6.7 Comparative Production Example 1 0

In the above [Table 2], the liquid crystals stabilized Gomari, henna, baekhwasachocho supercritical extract according to the present invention compared to Preparation Example 1 used as Gomari, henna, baekhwasachocho extract and Gomari, Henna, Baekhwasacho supercritical extract. It can be seen that the penetration effect is about 22 times and 5.8 times. As a result, the average particle size of the liquid crystal fragment of the present invention is very small to 50nm or less, it can be seen that skin penetration is very easy.

(Test Example 2)

Liposomal mucosal stimulation test containing Gomari, Henna and P. vulgaris supercritical extracts The acute stimulation of the mucosa was evaluated using HET-CAM as an alternative to the DRIZE eye irritation test. The test method was conducted according to EC standard.

① Prepare 6 eggs per test substance.

② Carefully wash with physiological saline when it reaches 30 seconds with stopwatch after material application.

③ Evaluate the reaction after 30 seconds and be careful not to damage the CAM during tearing.

④ Distinguish the degree of each reaction in the same way as the previous experiment and evaluate it according to the following evaluation criteria.

Test results for this are shown in the following [Table 3].

Q score evaluation Preparation Example 1 7 irritating moderately Preparation Example 2 6 slightly irritating Preparation Example 3 2 slightly irritating Comparative Production Example 1 3 slightly irritating

[Evaluation standard] 0 = none

                1 = weak

                2 = moderate

                3 = strong reaction

  For this purpose, the test substance is applied to the villus angle of fertilized eggs.

End point reaction method (End-point method) The conversion score determination table of the HET-CAM is shown in Table 4 below.

Q score evaluation slightly irritating moderately irritating irritating severely irritating Less than 6 + ◎ 6≤Q≤12 ++ ◎ 12≤Q≤16 +++ ◎ 16 or more ++++ ◎

The hatching rate, hatching state, and egg egg hatching state of the oviposition were selected by selecting relatively good ones. Gomari, henna, and P. vulgaris supercritical extracts) and Preparation Example 1 (Gomari, Henna, P. vulgaris extract) showed better permeability. As it is confirmed, it can be seen that the safety of the transmittance is also particularly excellent.

In vivo test

(Test Example 3)

Morphological damage to the cuticle due to permanent hair staining

The hair dye was used as a permanent hair dye and it was a product (DEMI MILEUM X9 / Y, Nita Chemical Co., Ltd.) that can obtain dark yellow hair, a color commonly used in the market. The PRIMARY INTERMEDIATOR of the staining agent contained p-nitro-o-phenylendiamine, couples resorcin, p-aminophenol, sulfate-o-chloro-p-phenylene diamine, and hydrogen peroxide as oxidant. The preparation of the medicament was prepared by mixing the preparations 1, 2, 3 and Comparative Preparation Example 1 in a ratio of 1: 1: 0.2 according to the method of use.

After the procedure, the dye was applied to the upper arm using a dye to be used for the study in advance and dried naturally. After 2 days and 4 days, the reactions were observed, respectively. The procedure was performed.

Staining was performed for 30 minutes. Hair was collected before staining and observed by scanning electron microscopy. Observation sites minimized the parameters of hair damage by observing the head of the head, which is located the least 5 cm from the proximal part, which is the least part of traction damage such as combing.

After 1 hour and 15 days after staining, the results were observed and the results are shown in [Table 5].

[Evaluation standard]

0 = none: The cuticle shows a smooth outline, and the scales overlap the scale regularly (Fig. 1).

1 = weak: When the edges of the insulting appear irregular and the boundary between the insulting is unclear, dissolution occurs (Fig. 2)

2 = moderate: when the damaged area is increased and the tear is lost (Figure 3)

3 = strong reaction: the edge of the cuticle is faintly observed to show a swelling (Fig. 4)

evaluation <Q> score / 1HOUR <Q> score / 15DAY Preparation Example 1 2.3 moderate 2.9 moderate Preparation Example 2 1.1 weak 1.6 weak Preparation Example 3 0.3 none 0.2 none Comparative Production Example 1 2.8 moderate 3.6 strong reaction

In [Table 5], the changes in the epidermis that appeared after hair dyeing showed a time difference. The initial change was shown in Preparation Example 3 using liposomes stabilized with Gomari, Henna and P. vulgaris supercritical extract. At 2, dissolution occurs in the hair's tear.

In addition, it turned out that both the manufacture example 1 and the comparative manufacture example 1 used the loss of a phosphorus. In addition, after 15 days, the change of hair was observed to be damaged more than 1 hour after dyeing, and in contrast to the restoration of hair damage as time passed in dyeing using Preparation Example 3, the remaining Preparation Example 1. It turns out that neither of the manufacture example 2 and the comparative manufacture example 1 used showed recovery. Therefore, Preparation Example 3 using liposomes stabilized with Gomari, henna, and P. vulgaris supercritical extracts had less irritation and reduced damage to the scalp and hair to restore damaged hair.

In addition, the binding of the human body hair protein over time to maintain a more stable color in the change of hair color. The results of hair combing, warpage, and static electricity of each subject were also found to be particularly excellent in using Preparation Example 3 using liposomes stabilized with Gomari, Henna, and Bleach.

In the preparation of the formulation using liposomes stabilized Gomari, henna, baekhwasacho supercritical extract is possible to manufacture the following cosmetics, but is not limited thereto.

(Formulation example 1)

 Skin cosmetic composition containing liposomes stabilized with Gomari, henna, and P. chinensis

Ingredient weight% Liposomes with Stabilized Gomari, Henna, and Bacteria Supercritical Extracts 15.0 1.3-butylene glycol 5.0 Allantoin 0.1 1% hyaluronic acid 1.0 glycerin 5.0 Polyoxyethylene Cured Castor Oil 0.5 Polyoxyethylene Hydrogenated Castor Oil 0.5 95% denatured ethanol 10.0 Benzophenone-9 0.05 antiseptic a very small amount incense a very small amount Purified water Remaining amount system 100

(Formulation Example 2)

Lotion cosmetic composition containing liposomes stabilized Gomari, henna, baekhwasachocho supercritical extract

Ingredient weight% Liposomes with Stabilized Gomari, Henna, and Bacteria Supercritical Extracts 5.0 1.3-butylene glycol 6.0 Glycerin 3.0 Triethanolamine 0.2 Polyacrylamide 0.5 Allantoin 0.1 Panthenol 0.1 Tocopheryl Acetate 1.0 Tri (capryl.capric acid) glycerin 3.0 Squalane 3.0 Cetyloctanoate 2.0 Dimethicone 1.0 Cyclomethicone 2.5 Cetostearyl alcohol 2.0 Stearic acid 1.5 Glyceryl Stearate 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Carboxy Vinyl Polymer 0.15 EtiTennii-2 yen 0.02 antiseptic a very small amount incense a very small amount Purified water to 100

(Formulation example 3)

Essence cosmetic composition containing liposomes stabilized in Gomari, henna, and P. vulgaris supercritical extract

Ingredient weight% Liposomes with Stabilized Gomari, Henna, and Bacteria Supercritical Extracts 10.0 1.3-butylene glycol 2.0 Glycerin 10.0 Triethanolamine 0.2 Polyacrylamide 0.5 Allantoin 0.1 Panthenol 0.1 Tocopheryl Acetate 0.5 Cyclomethicone 0.5 Polyoxyethylene Cured Castor Oil 0.5 Alcohol 5.0 Seaweed Extract 1.0 Carboxy Vinyl Polymer 0.2 EtiTennii-2 yen 0.02 antiseptic a very small amount incense a very small amount Purified water to 100

(Formulation Example 4)

Cream cosmetic composition containing liposomes stabilized Gomari, Henna, Pear vulgaris supercritical extract

Ingredient weight% Niposomes stabilized in Gomari, Henna, and Bleach 1.0 1.3-butylene glycol 7.0 Glycerin 2.0 Triethanolamine 0.3 Allantoin 0.1 Panthenol 0.1 Beeswax 2.0 Stearic acid 2.0 Tocopheryl Acetate 0.1 Polysorbate 60 2.5 Sorbitan sesquioleate 1.5 Isopropyl Palmitate 5.0 Cetostealin alcohol 2.0 Glyceryl Stearate 2.0 Liquid paraffin 40.0 Carboxy Vinyl Polymer 0.2 antiseptic a very small amount incense a very small amount Purified water to 100

Formulation Example 5

Massage cream cosmetic composition containing liposomes stabilized with Gomari, henna, and P. vulgaris supercritical extract

Ingredient weight% Niposomes stabilized in Gomari, Henna, and Bleach 1.0 1.3-butylene glycol 7.0 Glycerin 2.0 Triethanolamine 0.3 Allantoin 0.1 Panthenol 0.1 Beeswax 2.0 Stearic acid 2.0 Tocopheryl Acetate 0.1 Polysorbate 60 2.5 Sorbitan sesquioleate 1.5 Isopropyl Palmitate 5.0 Cetostealin alcohol 2.0 Glyceryl Stearate 2.0 Liquid paraffin 40.0 Carboxy Vinyl Polymer 0.2 antiseptic a very small amount incense a very small amount Purified water to 100

Formulation Example 6

Cleansing cream cosmetic composition containing liposomes stabilized in Gomari, Henna and P. vulgaris supercritical extract

Ingredient weight% Niposomes stabilized in Gomari, Henna, and Bleach 1.0 1.3-butylene glycol 7.0 Glycerin 2.0 Triethanolamine 0.3 Allantoin 0.1 Panthenol 0.1 Stearic acid 2.0 Micro Crystal Wax 0.5 Paraffin wax 0.5 Octyldodecanol 5.0 Tocopheryl Acetate 0.1 Polysorbate 60 2.5 Sorbitan sesquioleate 1.5 Isopropyl Palmitate 5.0 Cetostearyl alcohol 2.0 Glyceryl Stearate 2.0 Liquid paraffin 45.0 Carboxy Vinyl Polymer 0.2 antiseptic a very small amount incense a very small amount Purified water to 100

Formulation Example 7 Pack Cosmetic Composition Containing Liposomes Stabilized Gomari, Henna, and Pear Blossom

Ingredient weight% Niposomes stabilized in Gomari, Henna, and Bleach 1.0 1.3-butylene glycol 2.0 Glycerin 4.0 Carboxyl Vinyl Polymer 0.2 ethanol 7.0 Polyvinyl alcohol 15.0 Cellulose gum 0.2 Stearic acid 0.3 Octyldodecanol 1.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Allantoin 0.1 IDT-2N 0.01 antiseptic a very small amount incense a very small amount Purified water to 100

As described above, the present invention inhibits the moisturizing effect of the hair, the effect of preventing cracking, the softening effect, the overproduction of sebum associated with alopecia, and has a strong antibacterial action against hair growth and skin epithelial bacteria in the scalp and at the same time helps hair growth of young hair. It has the effect of thickening and strengthening thin and strengthless hair, and has the effect of improving the scalp and hair, and relieving skin irritation.

Claims (6)

Cosmetic composition, characterized in that the Gomari, henna, baekryamsachocho extract having a mixing ratio of 1: 1: 1 by weight of 0.01 to 20% by weight relative to the liposome. According to claim 1, wherein the weight percent of the liposomes containing Gomari, henna, baekryoksaul supercritical extract having a mixing ratio of 1: 1: 1, 0.01 to 20.0% by weight relative to the total weight of the conventional hair dye cosmetic composition Cosmetic composition, characterized in that. According to claim 1, wherein the weight percent of the liposomes containing Gomari, henna, baekryeoksaul supercritical extract having a mixing ratio of 1: 1: 1, 0.01 to 20.0% by weight relative to the total weight of the conventional skin type cosmetic composition Cosmetic composition, characterized in that. According to claim 1, wherein the liposomes containing Gomari, henna, baekryoksaul supercritical extract having a mixing ratio of 1: 1: 1 by weight of 0.01 to 20.0% by weight relative to the total weight of the conventional lotion type cosmetic composition Cosmetic composition, characterized in that. According to claim 1, wherein the weight percent of the liposomes containing Gomari, henna, baekryeoksaul supercritical extract having a mixing ratio of 1: 1: 1, 0.01 to 20.0% by weight relative to the total weight of the conventional essence-type cosmetic composition Cosmetic composition, characterized in that. According to claim 1, wherein the weight percent of the liposomes containing Gomari, henna, baekryoksaul supercritical extract having a mixing ratio of 1: 1: 1, 0.01 to 20.0% by weight relative to the total weight of the conventional cream type cosmetic composition Cosmetic composition, characterized in that.