KR100948204B1 - Composition for improving condition of hair and scalp containing a herb extracts mixture stabilized by liposome - Google Patents

Abstract

PURPOSE: A cosmetic composition containing a liposome having medicinal herb extracts is provided to maximize penetration effect to skin and hair and promoter hair growth. CONSTITUTION: A cosmetic composition for hair care contains: 0.01-50 weight% of scalp targeted liposome having Phellinus linteus, Thuja orientalis L. Portulaca oleracea L., Rumex crispus L., Zingiber officinale, Asian Celandine, and Artermisia argyi Lev. Et Vant. extract mixture; and 0.01-50 weight% of hair targeted liposome having henna, Houttuynia cordata Thunberg, Multiflorus, Acorus calamus var. angustatus, Saururus chinensis, and black soybean extract. The diameter of the average particle of the scalp targeted liposome is 100-200 nm. The diameter of the averge particle of the hair targeted liposome is 50-150 nm.

Description

Composition for improving condition of hair and scalp containing a herb extracts mixture stabilized by liposome}

The present invention relates to a cosmetic composition comprising a liposome comprising an herbal extract as an active ingredient, and more specifically, a scalp-targeted liposome and a hair-targeted type including a herbal extract consisting of a situation mushroom, a white leaf, a henna and a fish herb. It relates to a hair care cosmetic composition containing a liposome (liposome) as an active ingredient.

In modern society that emphasizes beauty, many people of all ages, including men and women, use hair dye and perm to satisfy their individual expression needs. However, some of the sensitive scalp may cause irritation and inflammation such as itching or stinging of the scalp by chemical treatment such as dyeing and perming. This irritation and inflammation leads to environmental hair loss, and various studies are being actively conducted to prevent hair loss and promote hair growth of men or women who are suffering from severe mental pain.

Therefore, various techniques for more stable and easy capture of agonists in the formulation for the treatment of hair loss have been developed. Particularly, in the area of hair growth, liposomes are used for the purpose of enhancing the efficacy by safely delivering the collected agonists to the hair follicles. In recent years, researches on developing and improving the field have been widely conducted (Follicular liposomal delivery systems. J Liposome Res. 2002, 12: 143-8), and studies on nanoparticle delivery systems have been extensively performed.

Accordingly, the present inventors have studied to overcome the instability of the conventional nanoparticles as described above, and to develop nanoparticles that can more efficiently and effectively capture and deliver physiologically active substances, resulting in binding between different cells of the scalp and hair. By using the properties of the substance, the herbal extract consisting of edible mushrooms, cypresses, henna, and fish herb can be used to produce particles optimized for scalp and hair, so that poorly soluble bioactive active ingredients can be collected in the water phase. It was confirmed that the present invention was completed.

An object of the present invention is to achieve a significantly increased skin absorption by effectively using the ingredients of the herbal extract consisting of situation mushrooms, cypresses, henna and fish herb, scalp targets that can maximize the skin penetration effect of the herbal extracts It is intended to provide type liposomes and hair targeted liposomes.

An object of the present invention is to use the properties of different intercellular binding materials of the scalp and hair respectively, scalp-targeted liposomes and hair-targeted liposomes that can maximize the synergy of the complex effect of the herbal extracts. It is to provide a cosmetic composition for hair care comprising (liposome) as an active ingredient.

The present invention is to provide a liposome (liposome) containing a herbal extract consisting of situation mushrooms, baekryeop, henna and eoseongcho to achieve the above object, more specifically comprising the medicinal mushrooms and baekyeopyeon extract as an effective scalp extract It provides a hair targeted liposome comprising a scalp targeted liposome and henna and fish herb extract as a hair effective extract.

In addition, the present invention provides a hair care cosmetic composition comprising a scalp-targeted liposome and a hair-targeted liposome including the herbal extract consisting of the above situation mushrooms, baekryeop, henna and fish herb as an active ingredient. .

Hereinafter, the present invention will be described in detail.

The present invention is characterized in that it provides a scalp-targeted liposome comprising a medicinal herb extract of a situation mushroom and a white leaf as an effective herbal extract of the scalp, and also a hair-targeted type comprising a herbal extract of henna and Echo herb as a hair-effective extract. It is characterized by providing a liposome (liposome).

The scalp-targeted liposomes according to the present invention are prepared by further comprising any one or more herbal extract mixtures selected from red pepper, machi, russuki, ginger and larvae as herbal extracts of medicinal mushrooms and cypresses. Characterized in that the hair-targeted liposome (liposome) is characterized in that it is prepared by further comprising any one or more herbal extract mixture selected from the herbal extracts of henna and eoseongcho, sewage, irises, triticale and black beans.

In more detail, the scalp-targeted liposomes further include any one or more herbal extract mixtures selected from red pepper, machi, rusbu, ginger, and larvae, as scalp-effective herb extracts, as well as medicinal extracts of situational mushrooms and cypresses, The hair-targeted liposome is characterized in that it is prepared by further comprising any one or more herbal extract mixtures selected from the herb extracts of henna and fish vinegar as sesame effective extracts, sewage, irises, triticales and black beans.

Scalp-targeted liposomes and hair-targeted liposomes according to the present invention are oil-containing parts containing phospholipids, lower alcohols, vegetable oils, emulsifiers and surfactants containing purified water, EDTA and herbal extracts. It is prepared by emulsifying the water phase, the herbal extracts include herbal extracts consisting of situation mushrooms, cypresses, henna and eoseongcho and from red peppers, machi, rousal, ginger, leaf, creation, sewage, irises, triticale and black beans It is characterized in that it further comprises an extract mixture of one or more herbal medicines selected.

The herbal extract is obtained by adding a mixed extraction solvent containing water, alcohol-based and glycol-based in an amount of 10 to 30 times the weight of the herbal plant, and then extracted for 5 to 20 hours at a temperature of 50 to 100 ℃ It features.

The alcohol is at least one selected from the group consisting of methanol, ethanol, propanol and butanol, the glycol is at least one selected from ethylene glycol, propylene glycol and butylene glycol, the water, alcohol and glycol is 1 Mixed extractive solvents are used which are mixed in a weight ratio of 2 to 4: 2 to 4: 0.5 to 2.

The herbal extracts according to the present invention are to be extracted separately, in order to share all the main components having the efficacy of each of the herbal extracts. If it is presumed that all of the herbal plants are extracted at once, the components of the herb will not be unified and the effects thereof will not be guaranteed.

Scalp-targeted liposomes and hair-targeted liposomes according to the present invention are characterized in that the average particle diameter is 10 to 250 nm.

More specifically, the scalp evolved liposome (liposome) is phosphatidylcholine (Phosphatidylcholine (PC) 0.5 to 10% by weight, ethanol 60 to 80% by weight, Tween 80 0.1 to 1.0% by weight, cetyl alcohol (Cetyl alcohol) 5 to 20 It is prepared by emulsifying the oil phase portion containing 0.5% to 15% by weight of polyglyceryl-3 methylglucose distearate and the water phase containing purified water, EDTA and herbal extracts. As, the herbal extracts include a medicinal mushroom extract mixture of situation mushrooms, cypresses, machi, sorugi, ginger, celandine and larvae, according to a preferred embodiment The weight ratio of the extract is mixed at 3: 2: 1: 1: 1: 1: 1.

In the prepared scalp-targeted liposomes, nonionic liposomes having an average particle diameter of 100 to 200 nm were prepared. See A of FIG. 1.

As a more specific example, the hair-targeted liposome is 0.5 to 10% by weight of phosphatidyl-ethanolamine (PE), 60 to 80% by weight of ethanol, 5 to 20% by weight of cetyl alcohol, polyglycerol Oil portion containing 0.5 to 15% by weight of polyglyceryl-3 methylglucose distearate and 0.1 to 1.0% by weight of cocamide propyl betain is purified water, EDTA and herbal medicine. It is prepared by emulsifying the aqueous phase containing the extract, wherein the herbal extract comprises henna, eoseongcho, creation, sewage, irises, three hundred seconds and black herb extract mixture, according to a more preferred embodiment henna, eoseongcho, creation, The weight ratio of sewage, iris, triticale and black soybean extract is 3: 2: 1: 1: 1: 1: 1 is mixed.

The prepared hair-targeted liposomes are ionic liposomes having an average particle diameter of 50 to 150 nm, which do not grow larger than nonionics by electrical repulsion, and differ in size and shape from the scalp-targeted liposomes. Check that there is. See B of FIG. 1.

Scalp-targeted liposomes and hair-targeted liposomes according to the present invention are various additives, dispersants or surfactants to overcome the low stability of colloids or mechanical processes requiring high energy which are disadvantages of conventional liposomes. Nanoparticles are stably formed by self-association of the molecules themselves without the use of such materials.

Scalp-targeted liposomes and hair-targeted liposomes according to the present invention dissolve various types of poorly soluble substances and at the same time stabilize the unstable substances to maximize the skin penetration effect according to different cells of the scalp and hair. There is an advantage to this.

The present invention provides a cosmetic composition for hair care containing a scalp-targeted liposome and a hair-targeted liposome containing the herbal extract consisting of the above-mentioned mushrooms, cypresses, henna and eochocho as active ingredients.

In the present invention, the liposome is 0.01 to 30% by weight relative to the total weight of the composition, preferably 5 to 20% by weight.

In addition, the herbal extract is 0.01 to 50% by weight relative to the total weight of the liposome (liposome), preferably 0.1 to 10% by weight.

In addition, the cosmetic composition according to the present invention is a scalp-targeted liposome and a hair-targeted liposome prepared by collecting a high concentration of poorly soluble physiologically active ingredients, ie, hair growth or hair growth active ingredients, and stably dispersing them in an aqueous phase. It can contain a decrease in acute toxic effects that can occur when the agonist is applied to a living body, and can increase the absorption rate compared to other formulations, is stable in various formulations, and safely decomposed in the body upon absorption in the body It has the advantage of being biocompatible.

More specifically, the scalp-effective extracts targeting the scalp are encapsulated in the scalp-targeted liposome, which can maximize the nourishment of the scalp, anti-inflammatory action, suppression of excessive fat release of the scalp, and inhibition of dandruff production. There is an advantage.

In addition, the hair-effective extracts that target the hair are enclosed in hair-targeted liposomes, which act on the hair to thicken the hair, increase the wool effect, moisturize and soften the hair, and inhibit hair damage. To maximize the hair and scalp target liposome according to the present invention has the advantage of maximizing the skin penetration effect of the active ingredient on the scalp and hair respectively.

Ingredients included in the cosmetic composition of the present invention includes components commonly used in cosmetic compositions in addition to scalp-targeted liposomes and hair-targeted liposomes containing a herbal extract mixture as an active ingredient, such as stabilizers And conventional auxiliaries and carriers such as solubilizers, vitamins, pigments and flavorings.

The cosmetic composition containing the scalp-targeted liposome and the hair-targeted liposome of the present invention as an active ingredient includes hair nourishing longevity, scalp treatment, hair tonic, hair conditioner, hair lotion, hair shampoo, hair rinse, It may be prepared in any one formulation selected from the group consisting of hair treatment and hair cream.

The cosmetic composition according to the present invention does not cause side effects such as toxicity, skin allergies, and skin troubles by using natural substances that are herbal medicines, and since the herbal medicines are stabilized by liposomes, the skin penetration effect is greatly increased and the stability of the formulation. There is also an effect that is greatly improved.

The cosmetic composition according to the present invention is prepared by including in the form of a hair care cosmetic in the form of a scalp-targeted liposome and a hair-targeted liposome, thereby maximizing the skin penetration effect according to different cells of the scalp and hair. By promoting cell metabolism, regenerating cells, activating cell nutrient supply, and normalizing physiological state, it has an excellent effect of improving the scalp and hair as well as preventing hair loss and promoting hair growth. It will contribute to the development of the beauty industry.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those of ordinary skill in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

[ Production Example  1 ~ 2] Preparation of Extract Mixture of Medicinal Plants

The herbal extract mixture of the present invention was prepared by mixing the prepared herbal extracts, respectively.

As a herbal medicine, 1 kg each of mushrooms, cypresses, machi, sorjugi, ginger, celandine, larvae, henna, eoseongcho, creation, sewage, iris, triticale and black soybeans are dried up to 10% of moisture content and weighed less than 10%. 10 minutes by volume of the mixed solvent prepared by mixing purified water, 95% ethanol and 1.3 butylene glycol in a weight ratio of 4: 4: 2, respectively.

After stirring the crude drug to which the mixed solvent was added and agitated for a week, it was obtained by maintaining for 85 hours in a water bath to extract for 10 hours.

The herbal extracts contained in the scalp-targeted liposomes were prepared by the addition of the herbal extracts shown in Table 1 below.

[ Production Example  3 to 4] containing herbal extracts Liposome  Produce

(1) Preparation of scalp-targeted liposomes

The herbal extract mixture of the present invention was prepared by mixing the prepared herbal extracts, respectively.

As a herbal medicine, 1 kg each of situation mushrooms, cypresses, machi, russe, ginger, celandine and young leaves were dried to 10% or less in water content, and cut into 10-15 cm in size, and purified water, 95% ethanol and 1.3 butylene glycol 10-fold volume was added to the mixed solvent prepared by mixing at a weight ratio of 4: 4: 2, respectively.

After stirring the crude drug to which the mixed solvent was added and agitated for a week, it was obtained by maintaining for 85 hours in a water bath to extract for 10 hours.

The herbal extracts contained in the scalp-targeted liposomes were prepared by the addition of the herbal extracts in Table 2 below.

Scalp-targeted liposomes were added to the aqueous phase in the aqueous phase with the composition of Table 3 below, and the mixture was heated and mixed to 70 ° C. The mixture of the aqueous phase and the oil phase was first emulsified at 2500 rpm with an Auto Homo MIxer for 5 minutes to produce a coarse emulsion, and after 5 minutes was accumulated, the second emulsified again for 5 minutes to have an average particle diameter of 100 to 200. Scalp-targeted liposomes of nm were obtained.

(2) hair target type Liposomes  Produce

The herbal extract mixture of the present invention was prepared by mixing the prepared herbal extracts, respectively.

As a herbal medicine, 1 kg each of Henna, Eoseongcho, Creation, Sewage, Irises, Triticalum and Black Beans was dried to 10% or less in water content, and cut into 10-15cm in size, followed by purified water, 95% ethanol and 1.3 butylene glycol, respectively 4: 10 times the volume of the mixed solvent prepared by mixing at a weight ratio of 4: 2 was added.

After stirring the crude drug to which the mixed solvent was added and agitated for a week, it was obtained by maintaining for 85 hours in a water bath to extract for 10 hours.

The herbal extracts contained in the hair-targeted liposomes were prepared by the addition of the herbal extracts in Table 4 below.

The hair-targeted liposome was added to the water phase in the water phase with the composition of Table 5 and mixed by heating to 70 ° C. The mixture of the aqueous phase and the oil phase was first emulsified at 2500 rpm with an Auto Homo MIxer for 5 minutes to produce a coarse emulsion, and after 5 minutes was deposited, the second emulsified again for 5 minutes to have an average particle diameter of 50 to 150. Hair target liposomes of nm were obtained.

Test Example 1 Particle Observation of Scalp Targeted Liposomes and Hair Targeted Liposomes

The scalp-targeted liposomes and hair-targeted liposomes prepared according to the methods of Preparation Examples 3 and 4 of the present invention were observed with a particle by electron microscope (Trandmission Electron Microscope, TEM), as shown in FIG. Targeted liposomes were nonionic liposomes with average particle diameters of 100 to 200 nm, which were confirmed to be different in size and shape from the following ionic hair target liposomes.

On the other hand, as shown in B of FIG. 1, the hair-targeted liposomes are ionic liposomes, and particles having a size smaller than the scalp-targeted liposomes having an average particle diameter of 50 to 150 nm were generated, which were larger than the nonionics due to electrical repulsive force. It was confirmed that it could not grow.

[Comparative Examples 1 and 2 and Examples 1 to 3]

To prepare a shampoo formulation of Comparative Examples 1-2 and Examples 1-3 with the composition of Table 6.

Comparative Example 1 was prepared to contain the extract mixture of the situation mushroom, cypress lobe, henna and eochocho of Preparation Example 1 as an active ingredient of the shampoo, Comparative Example 2, the situation mushroom, baekyeop, henna, eochocho, An extract mixture of red pepper, machi, sorbus, ginger, leaf, creation, sewage, iris, triticale and black soybean was prepared to contain as an active ingredient of the shampoo.

Example 1 was prepared to contain only the scalp-targeted liposome prepared in Preparation Example 3 as an active ingredient of the shampoo, Example 2 shampoo only the hair-targeted liposome prepared in Preparation Example 4 It was prepared to be contained as an active ingredient of the agent. Example 3 prepared a shampoo to contain both the scalp-targeted liposome prepared in Preparation Example 3 and the hair-targeted liposome prepared in Preparation Example 4 as an active ingredient.

[effect Test Example ]

Dandruff, hair loss and hair loss were tested using the shampoos prepared in Comparative Examples 1 and 2 and Examples 1 to 3, and the test results are shown in Table 7 below.

Forty patients with progression of hair loss among men and women in their 40s and 60s were divided into two groups so that their groups were similar in type and degree, and the shampoos prepared in Comparative Examples 1 to 2 and Examples 1 to 3 were performed every evening. After 4 months, its effectiveness was evaluated.

The evaluation criteria were expressed as a 5-point measure for the evaluation items of dandruff reduction, hair loss reduction and hair loss increase in the scalp. The results were divided into very good (5 points), good (4 points), good (3 points), normal (2 points), bad (1 point), and very bad (0 points) and expressed as average values.

Through the above results in the shampoo composition containing the scalp-targeted liposomes, hair-targeted liposomes and mixed liposomes of Examples 1 to 3 as an active ingredient than the extract mixture of the comparative example in the effects on dandruff reduction, hair loss reduction and hair loss increase A surprising improvement in the effect was confirmed, which can be seen in Figure 2, as a whole confirmed the hair regeneration effect of 50 to 95%.

In addition, the extract mixtures of Sichuan mushrooms, cypresses, henna and eochocho contain more extracts of red pepper, machi, soruzoi, ginger, larvae, creation, sewage, irises, triticale and black soybeans for each effect of the herbal extract mixture. It was confirmed that the synergy of the compound effect is maximized.

However, as can be seen in the effects of Table 7, the synergistic effect of the herbal extracts on the scalp and hair can be optimized by stabilizing the herbal extract mixture with the scalp-targeted liposomes and the hair-targeted liposomes, and the scalp-targeted liposomes. When using the hair-targeted liposomes and 1: 1 ratio than when using each, it was confirmed that it has a maximum effect of reducing dandruff, reducing hair loss and hair growth.

1 is an electron micrograph of the scalp-targeted liposome (A) and the hair-targeted liposome (B) according to the present invention.

2 is a result confirming the hair growth promoting effect of the cosmetic composition according to the present invention.

(A: before use, B: after use)

Claims (7)

Scalp-targeted liposomes including extract mixtures of situational mushrooms, cypresses, machissula, borage, ginger, celandine and larvae; Hair-targeted liposomes, including extract mixtures of henna, eochocho, creation, sewage, iris, triticale and black soybean; Or a mixed liposome thereof (liposome); cosmetic composition for hair care containing as an active ingredient. The method of claim 1, The active ingredient is a cosmetic composition for hair care, characterized in that it contains 0.01 to 30% by weight liposome (liposome) based on the total weight of the composition. The method of claim 1, The extract mixture of the situation mushrooms, cypresses, machissula, borage, ginger, celandine and larvae is contained in an amount of 0.01 to 50% by weight based on the total weight of the scalp-targeted liposomes; Henna, eoseongcho, creation, sewage, irises, triticale and black soybean extract mixtures containing 0.01 to 50% by weight based on the total weight of the hair target liposome (liposome). The method of claim 1, The scalp target liposome (liposome) is the average particle diameter of 100 to 200 nm, the hair target liposome (liposome) is a hair care cosmetic composition, characterized in that the average particle diameter of 50 to 150 nm. The method of claim 4, wherein The scalp-targeted liposome may be 0.5-10% by weight of phosphatidylcholine (PC), 60-80% by weight of ethanol, 0.1-1.0% by weight of tween 80, 5-20% by weight of cetyl alcohol, and The oily part containing 0.5 to 15% by weight of polyglyceryl-3 methylglucose distearate is purified water, EDTA, and situation mushrooms, cypresses, machis, broccoli, ginger, celandine and larvae. Cosmetic composition for hair care characterized in that it is prepared by emulsifying in the water phase containing the extract mixture. The method of claim 4, wherein The hair-targeted liposome is 0.5-10% by weight of phosphatidyl-ethanolamine (PE), 60-80% by weight of ethanol, 5-20% by weight of cetyl alcohol, polyglyceryl-3 methyl Oil phase containing 0.5 to 15% by weight of polyglyceryl-3 methylglucose distearate and 0.1 to 1.0% by weight of cocamide propyl betain, purified water, EDTA and henna, fish herb, creation , Sewage, irises, three hundred seconds and black hair cosmetic composition for hair care characterized in that it is prepared by emulsifying in the water phase containing the mixture. The method of claim 1, The cosmetic composition for hair care, characterized in that any one selected from the group consisting of hair nourishing cosmetics, scalp treatment, hair tonic, hair conditioner, hair lotion, hair shampoo, hair rinse, hair treatment and hair cream Cosmetic composition.

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