KR101984745B1 - Cosmetic composition for promoting hair growth comprising extract mixture of Houttuynia cordata, Calendula arvensis and Phellinus linteus as effective component - Google Patents

Abstract

More particularly, the present invention relates to a cosmetic composition for accelerating hair growth comprising an extractive mixture of Sophora japonica, Marigold and Pseudomonas mushroom as an active ingredient, and more particularly, to a cosmetic composition for accelerating hair growth comprising an extract mixture of Sophora japonica, Marigold, It increases the thickness and tensile strength of the hair and decreases the degree of swelling and the solubility of the alkali in comparison with that of the single extract, so that it can be more effectively used in hair cosmetic composition.

Description

[0001] The present invention relates to a cosmetic composition for promoting hair growth, which contains an extract mixture of Allium cepa L., Marigold,

The present invention relates to a cosmetic composition for accelerating hair growth, which comprises an extract mixture of Rhododendron japonica, Marigold and Mushroom as an active ingredient.

The hair of the human body is about 100,000 to 150,000, and each hair has a different parenting cycle and is repeatedly produced, grown and dislodged by anagen, catagen and telogen, Approximately 15% of the total hair is placed in the dormant period and the retrograde period, so that an average of 50 to 100 hairs are normally dropped and reproduced. These hair growth cycles repeat about 3 to 6 years in cycles. In general, alopecia refers to the fact that the period corresponding to the anagen of the hair cycle is shortened due to various causes, the ratio of the retrograde hair to the resting hair is relatively increased, Has a genetic androgen-hormone action, malnutrition due to local blood flow disorder, autonomic nervous system disorder, autoimmune disease, endocrine disorder, but the cause of hair loss is unknown until now, . The roots of hair growth hair roots are called hair bulbs, and the depressions in the lower part are called the papillae. The papilla is the most important part in the development of hair. The papilla has blood vessels and nerves, and nourishes the hair cells just above it, thereby promoting hair growth. The number of these papillae is determined at birth, and as the number of papillae disappears, the number of hairs decreases.

Recently, the number of people causing abnormal hair loss due to changes in dietary habits, lifestyle changes, and excessive stress due to the social environment is gradually increasing. Especially, the number of young and elderly women and female hair loss is increasing. On the other hand, hair loss, which means that hair or hairs are less or no more than normal due to any cause, is distinguished from general hair loss phenomenon (telogen effluvium) in which hair comes off from resting state and anagen effluvium which is abnormal hair loss phenomenon The term "alopecia" generally refers to the latter. The forms of alopecia include alopecia areata, early alopecia, androgen alopecia in women, alopecia alopecia, and male pattern baldness.

Testosterone is involved in male sexual dysfunction, skeletal muscle development, male genital development, scrotum growth, and spermatogenesis, and acne, sebum enlargement, hair loss, and prostatic hypertrophy are involved in the expression of male trait, . Among them, men 's hair loss, which is a male hormone - dependent disease, is causing serious mental suffering to men in modern society that emphasizes beauty. Therefore, researches to clarify the mechanism of hair loss and to improve it are being actively carried out. 5 alpha-reductase is a testosterone that is present in male hormone-reactive tissues such as sebaceous glands, hair follicles, prostate or epididymis, and is a biosynthesized testosterone in diabetic testosterone, dihydrotestosterone (DHT) . It is known that NADPH is used as a coenzyme in such a conversion process. After puberty, excess secreted dihydrotestosterone acts as a major cause of excess sebum production in sebocytes, leading to acne and male hair loss. In particular, many hair follicles provide a cause for hair loss because dihydrootestosterone binds better to the hormone receptor than testosterone.

Accordingly, studies have been actively conducted to develop a substance that inhibits the activity and production of 5 alpha-reductase, which promotes the production of dihydrootestosterone, and use it as a hair growth inhibitor or an anti-hair loss agent. In the past, female hormones such as estrogen have been used for the treatment of male pattern baldness. However, female hormones have been reported to cause skin irritation and side effects due to administration of hormones compared to their effects. It is in use. In recent years, Merck of America has synthesized finasteride (proscar), which inhibits the action of 5-alpha-reductase and inhibits the production of dihydrootestosterone, and market it as a hair growth promoter for oral administration. However, And the application is limited, for example, when the composition is applied directly to the composition, the effect is poor and other side effects are caused by the oral administration. In addition, there is Minoxidil of Upjohn Co., Ltd., which is a representative hair growth promoting drug that has been used so far to promote hair growth. Minoxidil was used as an antihypertensive agent. Which promotes hair growth by increasing the flow of hair follicles where hair follicles are located. However, when minoxidil is used as a hair growth promoting agent for a long time, the effect is halved and side effects due to chemical vasodilating action are reported as asthenia and sebum increase.

Meanwhile, Houttuynia cordata thunb.) is a prey of anilines, a plant of Saururaceae, which lives in southeastern Asia and especially in Japan and Korea. It is said that there are ten kinds of phytophthora, and the stem is like leaf of sweet potato. It can be used for medicinal and edible purposes. It is classified as a plant or a plant which can only use the minimum amount as a supplementary ingredient in food raw materials classification. It is widely known to have pharmacological effects such as strength, diuretic, antimicrobial, Is used as a cosmetic and health functional food for detoxification and beauty.

Calendula arvensis L.) is an annual plant of Asteraceae. Its name means flower which resembles a golden liquor. Flowers bloom in June-September, fruits ripen in August-October, 20 ~ It is an annual plant growing about 60cm. It is relatively cold resistant. Marigold petals contain a large amount of lutein pigment, which is orange-colored, accounting for about 90% of the pigment contained in the petals. It contains petrol, gouache, resin and gum, and the flowering fluid is used as a wetting agent or spreading agent for burns, bubbles, trauma, frostbite, eczema, and purulent acne.

Phellinus linteus ) is known as Basidiomycotina, Aphyllophorales, and white rot fungi belonging to Hymenochaetaceae , and Phellinus linteus , a typical example of Phellinus species . However, in Korea, a representative cultivar is Phellinus baumii , which accounts for more than 98% of the total off-farmers. Unusually, it is known that the only place where mushroom baumi is allowed to be used as food for health promotion is Korea. So far, various studies on the separation of physiologically active substances from mushrooms have been carried out continuously. Changes in efficacy and evaluation of extracts are under review.

Korean Patent Laid-Open Publication No. 2016-0095993 discloses a cosmetic composition for preventing depilation and hair growth using natural mushrooms and natural complexes and a method for producing the same, and Korean Patent No. 1661245 discloses a cosmetic composition for preventing hair loss, , Peony root, peony, yeast extract, safflower containing skin and scalp, hair loss prevention composition, and a process for producing the same. However, the cosmetic composition for accelerating hair growth containing the extract mixture of Hibiscus, Marigold and Phellinus linteus as an active ingredient of the present invention has not yet been disclosed.

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned needs, and it is an object of the present invention to provide a method of preparing a mixture of 1%, 5% and 10% by weight of a mixture obtained by mixing Sophora japonica, Marigold, As a result of preparing the shampoo composition and treating it with hair, it was found that the shampoo composition of the present invention contained 10% by weight of the extract mixture of the herringbone, marigold and mushroom of the present invention, especially compared to each shampoo composition containing 10% by weight of the sole extract, The present inventors have completed the present invention by confirming that the shampoo composition significantly increases the thickness and tensile strength of hair and shows a statistically significant difference in water swelling degree and alkali solubility.

In order to solve the above-mentioned problems, the present invention provides a cosmetic composition for promoting hair growth or wool, comprising an extract mixture of Hibiscus, Marigold and Pseudomonas mushroom as an active ingredient.

Since the extract mixture of Hwasungsu, Marigold and Mushroom of the present invention further increases the thickness and tensile strength of hair and further reduces the water swelling degree and alkali solubility, compared to the sole extract of marine mushroom, marigold and mushroom alone, It can be more usefully used in a cosmetic composition.

FIG. 1 shows the results of measuring the change in thickness of hair according to the treatment of the extract mixture of Hibiscus, Marigold, and Shiitake mushroom of the present invention. control refers to a control without any treatment, PS refers to a general shampoo, and mixing refers to a shampoo containing a mixture of a sole extract of each of australia, marigold and mushroom at a weight ratio of 5: 3: 3.
FIG. 2 shows the results of measuring the tensile strength of hair according to the treatment of the extract mixture of Rhododendron, Marigold and Phellinus linteus according to the present invention.
FIG. 3 is a result of measurement of the water swelling degree of the hair according to the treatment of the extract mixture of Hibiscus, Marigold and Mushroom of the present invention.
FIG. 4 shows the results of measuring the alkali solubility of the hair according to the treatment of the extract mixture of Hibiscus, Marigold, and Shiitake mushroom of the present invention.

In order to accomplish the object of the present invention, the present invention provides a cosmetic composition for accelerating hair growth, which comprises an extract mixture of Sophora japonica, Marigold and Mushroom as an active ingredient.

In the composition according to one embodiment of the present invention, the extraction may be performed using water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof, preferably ethanol, but the present invention is not limited thereto.

In addition, in the composition according to one embodiment of the present invention, the extract mixture of Sophora japonica, Marigold,

1) crushing the mushroom, marigold and mushroom to 150 ~ 350 mesh;

2) 30 to 50 parts by weight of ethanol is added to 1 part by weight of crushed greens, marigold and mushroom powder in step 1), and the mixture is extracted for 24 to 60 hours and filtered; And

3) mixing each of the extracts obtained in the step 2), and

Preferably,

1) crushing the mushroom, marigold and mushroom to 200-300 mesh;

2) 40 parts by weight of ethanol was added to 1 part by weight of crushed greens, marigolds and mushroom powder, respectively, and the mixture was extracted for 48 hours and filtered. And

And 3) mixing each of the extracts obtained in the step 2), but the present invention is not limited thereto.

In addition, in the composition according to an embodiment of the present invention, the mixture may be a mixture of a mushroom extract, a marigold extract and a mushroom extract in a weight ratio of 1: 10: 1 to 10: 1 to 10, 2 to 7: 1 to 5: 1 to 5 by weight, more preferably 5: 3: 3 by weight, but the present invention is not limited thereto.

In addition, in the composition according to an embodiment of the present invention, the extract obtained in step 3) may be an extract obtained by repeating the step 2) twice more preferably, the extract obtained in step 2) And extracts obtained by adding ethanol to the remainder of the filtrate and extracting and filtering the extract twice, and the extract is not limited thereto.

As used herein, the term " hair growth promoting " refers to promoting the production and growth of hair, ultimately increasing the specific gravity of growing hair in total hair. Therefore, the term has the same meaning as " hair loss improvement ", " hair loss prevention ", and " hair loss treatment " since it means suppressing hair loss caused by a decrease in specific gravity of growing hair.

In addition, in the composition according to one embodiment of the present invention, the extract mixture of the Rhododendron, Marigold and Phellinus linteus may contain 7.5 to 12.5 wt%, preferably 10 wt% But is not limited thereto.

In addition, in the composition according to an embodiment of the present invention, the cosmetic composition may be one prepared from a hair conditioner, a hair tonic, a hair cream, a hair lotion, a hair oil, a hair spray, a shampoo or a rinse, But the present invention is not limited thereto.

The cosmetic composition includes components commonly used in cosmetic compositions and includes, for example, customary adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and carriers. In addition, the cosmetic composition according to the present invention may be used in combination with a hair or hair restorer, which has been conventionally used, insofar as it does not impair the function (hair growth function) of the present invention, in addition to the extract mixture of sea urchin, marigold and mushroom.

As the carrier, it is possible to use purified water, monohydric alcohols (ethanol or propyl alcohol), polyhydric alcohols (glycerol, 1,3-butylene glycol or propylene glycol), higher fatty acids (palmitic acid or linolenic acid) But are not limited to, camellia oil, jojoba oil, olive oil, squalane, sunflower oil, macadamia peanut oil, avocado oil, soybean water-added lecithin or fatty acid glyceride). If necessary, a surfactant, a bactericide, an antioxidant, an ultraviolet absorber, an anti-inflammatory agent and a refreshing agent may be added.

The surfactant is selected from the group consisting of polyoxyethylene, hardened castor oil, polyoxyethylene, oleyl ether, polyoxyethylene monooleate, polyoxyethylene, glyceryl monostearate, monostearic acid sorbitan, monooleic acid polyoxyethylene, sorbitan, Polyglycerol fatty acid ester, sucrose fatty acid ester, monolauric acid hexaglycerin, polyoxyethylene reduced lanolin, POE, glyceryl pyroglutamic acid, isostearic acid, diester, N-acetylglutamine and isostearyl ester.

The fungicide may optionally be selected from the group consisting of: hynochitol, trichloro acid, chlorohexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid and zinc pyrithione have.

As the antioxidant, any of butylhydroxyanisole, gallic acid, propyl gallate, and erythorbic acid may be used.

The ultraviolet absorber may be at least one selected from the group consisting of benzophenones such as dihydroxybenzophenone and the like, melanin, ethyl paraaminobenzoate, 2-ethylhexyl paradimethylbenzoate, synonym, 2-ethylhexyl phamethoxycinnamate, 2- Hydroxy-5-methylphenyl) benzotriazole, urocanic acid, and metal oxide fine particles.

As the anti-inflammatory agent, dipotassium glycyrrhizinate or allantoin can be used, and as a refreshing agent, pepper tincture or 1-menthol can be used.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are merely illustrative of the present invention and that the scope of the present invention is not limited thereto.

Materials and methods

1. Manufacture of extracts of Persimmon, Marigold, and Situ mushroom

Mushrooms, marigolds, and mushrooms were purchased from Jiri Mountain D & H Company, and each of the dried materials was ground with a blender to have a mesh of 200 to 300 mesh. For the extraction of Houttuynia cordata, 50 g of Houttuynia cordata powder was added to 2,000 mL of 70% (v / v) ethanol and extracted at room temperature for 48 hours. The extracts were filtered with a filter (3M, USA) and stored at 4 ° C. After filtration, 500 mL of 70% (v / v) ethanol was added to the residue of the alleles and the mixture was mixed and extracted at room temperature for 24 hours. The extracts were filtered again and stored at 4 ° C. The extracts were filtered with filter and stored at 4 ° C. The extracts were stored at 4 ° C. After mixing, the mixture was concentrated under reduced pressure at 40 캜 and 55 rpm, lyophilized, and stored at 4 캜. For marigold extraction, 50 g of marigold powder was added to 1,000 mL of 70% (v / v) ethanol and extracted at room temperature for 48 hours. The subsequent process is the same as the above-described method for producing the perennial herb extract. To extract mushroom, 100 g of mushroom powder was added to 2,000 mL of 70% (v / v) ethanol and extracted at room temperature for 48 hours. The subsequent process is the same as the above-described method for producing the perennial herb extract.

2. Manufacture of a shampoo composition containing an extract mixture of Horseshoe chinensis, Marigold and Situ mushroom

Each of the lyophilized herbs, marigolds and mushroom extracts were mixed at a weight ratio of 5: 3: 3, and then shampoo compositions were prepared containing 1%, 5% and 10% (Additive 2). Specifically, Tween-80 was added to and dissolved in the oil raw material by adding the thickening agent to the water raw material and heated at 70 DEG C, and then the mixture was added with the surfactant, Additives 1 and 2 (Horsetail extract, Marigold extract, And the mixture was mixed with 5: 3: 3 by weight), a viscosifier, an acidity regulator and an EURO-Napre preservative. Thereafter, the natural fragrance was dropped, aged, and physical properties such as viscosity were confirmed. The hair shampoo of the present invention produced a natural bio-encapsulant using lanolin and jojoba raw materials in order to enhance the hair protecting effect. Lanolin is translucent, yellowish white, soft and absorbs quickly into the skin, and when jojoba is combined with the oil in the wax chain, it is adsorbed to the cuticle's membrane, deeply penetrating the nourishment of hair follicles along with hair protection and helping hair growth. In addition, herbs, marigolds, and mushrooms are deeply transferred to the root of the hair, which promotes hair growth along with nourishment to the hair follicles. Conventional shampoos use synthetic surfactants such as silicone, paraben, and ALS for shampoo usability, and it is difficult to expect hair loss prevention and hair growth. This hair shampoo is made of silicon-free, synthetic surfactant-free, and paraben free lamellar technology, and its natural ingredients are liquid crystal structure, which is closely adhered to the hair together with the protective ingredient to improve the stability of the raw material. .

3. Measurement of change of hair

In order to measure the physical changes of the hair, hair thickness, tensile strength, and the like were measured. In order to measure the physical change of the hair, the hair was taken from a position 10 mm away from the occiput, and about 300 to 400 hairs were cut in the zipper pack, , Water swelling degree and alkali solubility. The shampoo contains 5% and 10% of marigold extract, 5% and 10% of marigold extract, 5% and 10% of mushroom shampoo, (Containing 1, 5, and 10% of mixed shampoos with a mixture of soleus, marigold, and mushroom extracts) were each applied in an amount of 15 g each and left for 15 minutes. The thickness of the hair was measured by measuring the diameter of 10 of the hair of the prepared sample using a hair diagnosis machine. The tensile strength of the hair of the prepared sample was measured at a room temperature of 24 ° C and a humidity of 40% and the other was fixed to a movable specimen table with a length of 20 mm and moved at a speed of 2 mm / sec to measure the tensile strength. The water swelling degree of hair was measured by weighing 0.1 g of hair sample in a 50 ml tube, placing 15 ml of distilled water in the tube, immersing the hair sample in the tube for 30 minutes, compressing the hair through 4 pieces of filter paper, Results were obtained according to swelling degree calculation method. The alkali solubility of 0.1 g of hair sample was kept in 15 ml of 0.1N NaOH for 30 minutes, and the sample was dissolved in the filter paper. The solution was removed by hand, rinsed three times with distilled water, the water was removed again with filter paper, And dried for 30 minutes in an incubator set at a temperature of 20 ° C to obtain a result according to the calculation method of the alkali solubility.

4. Statistical processing

Statistical analysis was performed using SPSS version 24, and the mean and standard error were calculated for each test group. The ANOVA test was performed at p <0.5 and Duncan's multipe range test was used to verify the significant difference between the test groups.

Example  1. Identification of hair changes by treatment of extract mixture of Hwasungscho, Marigold, and Situ mushroom

(1) Thickness of hair

When hair was treated with PS group (general shampoo, 64.1 ± 3.5㎛) versus control group (Control, 61 ± 2.5㎛), hair thickness was measured by extractive mixture treatment of ginseng root, The hair was thickened by 5.1% and the thickness of hair was increased about 12% compared to the control (control: 68.3 ± 3.5 ㎛, containing 10% of horseradish extract, shampoo group) (10%) containing the extract mixture of the oriental mushroom, marigold and mushroom extract of the present invention was 72.3 ± 3.0 ㎛, respectively, as compared with the case where the shampoo containing the extract of Sambrook mushroom alone was treated on the hair, (Fig. 1).

(2) Tensile strength of hair

The tensile strength of the hair was about 1.5% higher than that of the control (control, 79.6 ± 6.9g) and PS group (general shampoo, 80.8 ± 6.4g) There was no difference. On the other hand, when treated with shampoo (10%) containing the extract mixture of Hibiscus japonica, Marigold, and Shiitake mushroom of the present invention, the shampoo containing the extract of Sophora japonica, Marigold and Situ mushroom alone was 95.9 ± 5.1 , Indicating that the tensile strength of the hair was significantly higher (FIG. 2).

(3) Water swelling degree of hair

As a result of measuring the degree of water swelling of hair, it was found that all treatments except control group (Control, 19.7%) and PS group (general shampoo, 19.6%) were significantly higher than those of shampoo group containing 5% (10%) containing the extract mixture of the oriental herb, marigold, and mushroom extract of the present invention was lower than that of the shampoo containing the herb extract, marigold, and mushroom extract alone, The degree of water swelling was significantly different from that of the control (Fig. 3).

(4) Solubility of alkali in hair

The alkali solubility of the hair was measured and the alkali solubility was significantly decreased in all treatments compared to the control (-15.8%) and PS (general shampoo, -15.1%). Especially, It was confirmed that the alkali solubility was reduced by more than 2 times when the shampoo (10%) containing the extract mixture of oriental mushroom, marigold and mushroom of the present invention was treated, compared with the case of treating each shampoo containing mushroom extract alone (Fig. 4).

Claims (5)

A cosmetic composition for accelerating hair growth, which comprises an extract of ethanol extract of Sophora japonica, Marigold and Mushroom as an active ingredient. delete [Claim 2] The cosmetic composition for promoting hair growth according to claim 1, wherein the mixture is a mixture of ethanol extract of Hwasungcho, ethanol extract of Marigold and ethanol extract of Hwasung mushroom at a weight ratio of 1 ~ 10: 1 ~ 10: 1 ~ 10. The cosmetic composition for accelerating hair growth according to claim 1, wherein the ethanol extract mixture of Sophora japonica, Marigold and Mushroom is 7.5 to 12.5% by weight based on the total weight of the composition. [2] The cosmetic composition for promoting hair growth according to claim 1, wherein the cosmetic composition is prepared from a hair conditioner, a hair tonic, a hair cream, a hair lotion, a hair oil, a hair spray, a shampoo or a rinse.

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