JP2005289870A

JP2005289870A - Cosmetic

Info

Publication number: JP2005289870A
Application number: JP2004106896A
Authority: JP
Inventors: Mitsuhiro Wada; 光弘和田; Hiroshi Tanaka; 弘田中; Mitsuhiro Nishida; 光宏西田
Original assignee: Naris Cosmetics Co Ltd
Current assignee: Naris Cosmetics Co Ltd
Priority date: 2004-03-31
Filing date: 2004-03-31
Publication date: 2005-10-20

Abstract

<P>PROBLEM TO BE SOLVED: To prepare a bleaching cosmetic enough having a bleaching effect, having no restriction when prepared, and highly safe. <P>SOLUTION: This bleaching cosmetic is prepared by mixing an extract obtained from a plant of the genus Cymbidium of the family Orchidaceae and an anti-inflammatory agent, such as glycyrrhizinic acid, glycyrrhetinic acid, and ε-aminocaproic acid, thereinto. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

Technical background

本発明は、美白化粧料に関し、更に詳しくは、ラン科シンビジューム属植物から得られる抽出物、及び抗炎症剤を配合することを特徴とする美白化粧料に関する。 The present invention relates to a whitening cosmetic, and more particularly to a whitening cosmetic characterized by containing an extract obtained from a plant belonging to the genus Orchidaceae and an anti-inflammatory agent.

近年、オゾン層の破壊による紫外線照射量の増加等による皮膚癌や皮膚トラブルの増加が指摘されている中、美白に関する関心も高く、多くの美白化粧料が市販されている。そして、市販されている美白化粧料には、メラニンの産生を抑制する機能を有する成分を配合したものや、産生したメラニンを還元する作用を有する成分を配合したもの、そして、その両方の機能を有するもの、又はその他の機能にて美白作用を有するものなど様々な機能面からのアプローチがなされている。 In recent years, while it has been pointed out that skin cancer and skin trouble increase due to an increase in the amount of ultraviolet irradiation due to the destruction of the ozone layer, there is a high interest in whitening, and many whitening cosmetics are commercially available. The whitening cosmetics that are commercially available are those that contain a component that has the function of suppressing the production of melanin, those that contain a component that has the action of reducing the produced melanin, and both functions. Various functional approaches such as those having a whitening effect by other functions or those having other functions have been made.

しかしながら、上記の美白化粧料では、有効成分に皮膚トラブルが生じる副作用を有するものや有効成分そのものが不安定で製剤化に制限を有するもの、そして、美白効果が低いもの等十分に美白効果を有し、製剤化に制限が無く、しかも安全性の高い美白化粧料が望まれていた。
特開２００１−４８７７３号広報特開２００２−３３３６号広報 However, the above-mentioned whitening cosmetics have a sufficient whitening effect, such as those that have side effects that cause skin troubles in the active ingredients, those that are unstable due to unstable active ingredients themselves, and those that have a low whitening effect. However, there has been a demand for a whitening cosmetic that has no restrictions on formulation and has high safety.
Japanese Laid-Open Patent Publication No. 2001-48773 Japanese Laid-Open Patent Publication No. 2002-3336

解決しようとする課題は、美白効果を十分に有し、製剤化に制限が無く、しかも安全性の高い美白化粧料を提供することである。 The problem to be solved is to provide a whitening cosmetic that has a sufficient whitening effect, has no restrictions on formulation, and has high safety.

本発明者らは、上記課題を達成するために鋭意研究を重ねた結果、ラン科シンビジューム属植物から得られる抽出物、及び抗炎症剤を配合することにより美白効果に優れ、しかも極めて高い安全性を有することを見出し、本発明を完成するに至った。 As a result of intensive studies to achieve the above-mentioned problems, the present inventors have an excellent whitening effect and an extremely high safety by incorporating an extract obtained from a plant belonging to the genus Orchidaceae and an anti-inflammatory agent. As a result, the present invention has been completed.

即ち、本発明は、ラン科シンビジューム属植物から得られる抽出物、及び抗炎症剤を含有することを特徴とする美白化粧料である。ラン科シンビジューム属植物は、従来より抗炎症効果や保湿効果を有する植物として知られていたが、グリチルリチン酸及びその誘導体、グリチルレチン酸及びその誘導体等の抗炎症剤とを併用することにより極めて高い安全性は勿論のこと、美白効果にも優れていることを見出し、高い安全性を有しかつ効果的な美白化粧料を提供するものである。 That is, the present invention is a whitening cosmetic comprising an extract obtained from a plant belonging to the genus Orchidaceae, and an anti-inflammatory agent. Orchidaceae Cymbidium plants have been known as plants having anti-inflammatory and moisturizing effects, but they are extremely safe when used in combination with anti-inflammatory agents such as glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives. The present invention has been found to be excellent in whitening effect as well as property, and provides a whitening cosmetic having high safety and effective.

本発明に用いることができるラン科シンビジューム属植物は、シンビジューム(Cymbidium
Orchidaceae)であれば特に制限はない。本発明のシンビジュームの抽出物は。シンビジュームの植物体、例えば葉、茎、根、種子、又はシンビジュームの組織培養物を公知の溶媒で抽出したものである。この公知の溶媒としては、例えば、水、アルコール類（メタノール、エタノール、プロピレングリコール等）、エーテル類（ジエチルエーテル等）、ケトン類 (アセトン等）、ハロゲン化炭化水素類（ジクロルメタン、クロロホルム等）などが挙げられる。また、抽出方法としては、上記の公知の溶媒の一種又は２種以上の混合溶媒を用い、加熱抽出したものでも、あるいは低温または常温抽出したものでもよい。 Orchidaceae Cymbidium plants that can be used in the present invention are Cymbidium.
Orchidaceae) is not particularly limited. What is the extract of the symbidium of the present invention? A plant body of a symbidium such as leaves, stems, roots, seeds, or a tissue culture of a symbidium is extracted with a known solvent. Examples of the known solvent include water, alcohols (methanol, ethanol, propylene glycol, etc.), ethers (diethyl ether, etc.), ketones (acetone, etc.), halogenated hydrocarbons (dichloromethane, chloroform, etc.), etc. Is mentioned. As the extraction method, one of the above-mentioned known solvents or a mixed solvent of two or more of them may be used for extraction by heating, or by extraction at a low temperature or normal temperature.

本発明に用いることができる抗炎症剤は、抗炎症効果を有する公知の成分であれば特に限定は無く、グリチルリチン酸及びその誘導体、グリチルレチン酸及びその誘導体、イプシロンアミノカプロン酸等が好ましい。 The anti-inflammatory agent that can be used in the present invention is not particularly limited as long as it is a known component having an anti-inflammatory effect, and glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, epsilon aminocaproic acid and the like are preferable.

シンビジュームの抽出物の美白化粧料に対する配合量は、有効であれば特に限定されないが、乾燥重量に換算して０．００１〜５０重量％が好ましく、更に０．０１〜５．０重量％が好ましい。又、抗炎症剤の美白化粧料に対する配合量は、有効であれば特に限定されないが、乾燥重量に換算して０．００１〜１０重量％が好ましく、更に０．０１〜５．０重量％が好ましい。 The blending amount of the symbidium extract to the whitening cosmetic is not particularly limited as long as it is effective, but is preferably 0.001 to 50% by weight, more preferably 0.01 to 5.0% by weight in terms of dry weight. . Further, the blending amount of the anti-inflammatory agent with respect to the whitening cosmetic is not particularly limited as long as it is effective, but is preferably 0.001 to 10% by weight, more preferably 0.01 to 5.0% by weight in terms of dry weight. preferable.

本発明の皮膚外用剤には、上記必須成分のほか、化粧品、医薬部外品、医薬品に用いられる水性成分、油性成分、植物性抽出物、動物抽出物、粉未、界面活性剤、油剤、アルコール、ｐＨ調整剤、防腐剤、酸化防止剤、増粘剤、色素、香料等を必要に応じて本発明の目的を達成する範囲内で適宜配合することが出来る。本発明の皮膚外用剤の剤型としては、化粧水、乳液、クリーム、パック、パウダー、スプレー・軟膏、分散液、洗浄料等種々の剤形とすることができる。例えば乳液等の場合、油相及び水相をそれぞれ加熱溶解したものを乳化分散して冷却する通常の方法により製造することができる。ただし、使用するタンパク分解酵素が不安定な場合、水が含まれる系ではマイクロカプセル化する等の周知の安定化製剤を使用することが好ましい。 In addition to the above essential components, the external preparation for skin of the present invention includes cosmetics, quasi drugs, aqueous components used in pharmaceuticals, oily components, plant extracts, animal extracts, powders, surfactants, oils, Alcohols, pH adjusters, preservatives, antioxidants, thickeners, pigments, fragrances, and the like can be appropriately blended within the range that achieves the object of the present invention, if necessary. As the dosage form of the external preparation for skin of the present invention, various dosage forms such as lotion, emulsion, cream, pack, powder, spray / ointment, dispersion, cleaning agent and the like can be used. For example, in the case of an emulsion or the like, it can be produced by an ordinary method of emulsifying and cooling an oil phase and an aqueous phase, which are dissolved by heating, and then cooling. However, when the proteolytic enzyme used is unstable, it is preferable to use a known stabilized preparation such as microencapsulation in a system containing water.

以下、本発明を実施例により説明するが、本実施例によって本発明が限定されるもの
ではない。 EXAMPLES Hereinafter, although an Example demonstrates this invention, this invention is not limited by this Example.

また、これに先立ち評価項目および方法に関して詳述する。各実施例共女性パネラー２０名に、実施例試料と比較例試料とを配布した後それぞれが3ヶ月間塗布した後、使用前と比較して美白効果を判定し、実施例試料と比較例試料との優劣を、表１〜表４に示した。 Prior to this, the evaluation items and methods will be described in detail. After each example sample and comparative example sample were distributed to 20 female panelists for each example, each was applied for 3 months, and then the whitening effect was judged compared to before use. The example sample and the comparative example sample Tables 1 to 4 show the superiority and inferiority.

表１には美容液に製剤化した実施例１及び比較例１の処方を、表２にはパネラーテストの結果を示した。また、パネラーテストの実施に際し、パネラー全員が皮膚への違和感や肌トラブル等の異常を認めず、満足した使用感触であったとの回答を得た。 Table 1 shows the formulations of Example 1 and Comparative Example 1 formulated into a cosmetic liquid, and Table 2 shows the results of the paneler test. Moreover, when conducting the paneler test, all panelists answered that they were satisfied with the feeling of use, with no discomfort to the skin or abnormalities such as skin troubles.

又、表３には乳液に製剤化した実施例２及び比較例２の処方を、表４にはパネラーテストの結果を示した。また、パネラーテストの実施に際し、美容液処方同様にパネラー全員が皮膚への違和感や肌トラブル等の異常を認めず、満足した使用感触であったとの回答を得た。 Table 3 shows the formulations of Example 2 and Comparative Example 2 formulated into an emulsion, and Table 4 shows the results of the paneler test. Moreover, when carrying out the paneler test, all the panelists did not recognize any abnormalities such as discomfort to the skin or skin troubles as in the case of the beauty serum formulation, and they answered that they were satisfied with the feeling of use.

表２及び表３より、本発明のシンビジューム抽出物及び抗炎症剤を合わせて配合することにより、美白効果に優れ、しかも刺激等がない極めて高い安全性の美白化粧料を得たことを示している。 From Tables 2 and 3, it is shown that by combining the symbidium extract of the present invention and the anti-inflammatory agent together, an extremely safe whitening cosmetic that is excellent in whitening and has no irritation is obtained. Yes.

本発明は、極めて高い安全性と優れた美白効果を有する美白化粧料であるため、化粧品はもとより医薬部外品等の外用剤として用途に広く適応できる。 Since the present invention is a whitening cosmetic composition having extremely high safety and an excellent whitening effect, it can be widely used as an external preparation for cosmetics and quasi-drugs.

Claims

A whitening cosmetic comprising an extract obtained from a plant belonging to the genus Orchidaceae and an anti-inflammatory agent.