CN109674717A - A kind of Transdermal absorption skin matrix of two-way function and preparation method thereof - Google Patents
A kind of Transdermal absorption skin matrix of two-way function and preparation method thereof Download PDFInfo
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- CN109674717A CN109674717A CN201910002628.8A CN201910002628A CN109674717A CN 109674717 A CN109674717 A CN 109674717A CN 201910002628 A CN201910002628 A CN 201910002628A CN 109674717 A CN109674717 A CN 109674717A
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- liposome
- skin
- transdermal absorption
- essence
- matrix
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- 238000010521 absorption reaction Methods 0.000 title claims abstract description 80
- 239000011159 matrix material Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000002502 liposome Substances 0.000 claims abstract description 102
- 208000008454 Hyperhidrosis Diseases 0.000 claims abstract description 40
- 208000013219 diaphoresis Diseases 0.000 claims abstract description 39
- 230000001939 inductive effect Effects 0.000 claims abstract description 39
- 235000020708 ginger extract Nutrition 0.000 claims abstract description 13
- 229940002508 ginger extract Drugs 0.000 claims abstract description 13
- 239000000419 plant extract Substances 0.000 claims abstract description 9
- 239000003963 antioxidant agent Substances 0.000 claims description 13
- 230000003078 antioxidant effect Effects 0.000 claims description 13
- 239000012071 phase Substances 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- 239000003381 stabilizer Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
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- -1 proppant Substances 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 4
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- 239000008346 aqueous phase Substances 0.000 claims description 3
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- 235000008397 ginger Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 2
- CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 claims description 2
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims description 2
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 claims description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims description 2
- 229940083466 soybean lecithin Drugs 0.000 claims description 2
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 claims description 2
- 229940032091 stigmasterol Drugs 0.000 claims description 2
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 claims description 2
- 235000016831 stigmasterol Nutrition 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229940076810 beta sitosterol Drugs 0.000 claims 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 229950005143 sitosterol Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 20
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- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
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- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 230000037380 skin damage Effects 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 92
- 239000000047 product Substances 0.000 description 20
- 239000011148 porous material Substances 0.000 description 11
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- 230000000052 comparative effect Effects 0.000 description 7
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- 239000002245 particle Substances 0.000 description 7
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- 210000002615 epidermis Anatomy 0.000 description 5
- 235000002780 gingerol Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 4
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
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- 238000010998 test method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
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- 238000002834 transmittance Methods 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 240000000572 Blumea balsamifera Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
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- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
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- 239000000823 artificial membrane Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- 238000013270 controlled release Methods 0.000 description 1
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- 239000003937 drug carrier Substances 0.000 description 1
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- 230000002500 effect on skin Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
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- 229950007687 macrogol ester Drugs 0.000 description 1
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- 230000003020 moisturizing effect Effects 0.000 description 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- 125000005314 unsaturated fatty acid group Chemical group 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses Transdermal absorption skin matrixes of a kind of two-way function and preparation method thereof.Transdermal absorption skin matrix includes essence Transdermal absorption liposome and skin inducing diaphoresis element liposome, it wherein include plant extract elite in the essence Transdermal absorption liposome, partial size is 50 ~ 200nm, includes ginger extract in the skin inducing diaphoresis element liposome, and partial size is 200 ~ 1000nm.Skin matrix of the invention includes that can carry out the essence Transdermal absorption liposome of deep layer nourishing to skin and essence Absorption And Metabolism product is promoted to be discharged in time, avoid the skin inducing diaphoresis element liposome of deposition and skin damage, realize the two-way Transdermal absorption of skin matrix, synthesis skin care effect with efficient nourishing, whitening agent anti-aging, preparation method is simple to operation, suitable for industrialized production, the production of skin matrix can be widely applied to.
Description
Technical field
The present invention relates to skin care technical fields, a kind of Transdermal absorption skin matrix more particularly, to two-way function and
Preparation method.
Background technique
Liposome is made of lipid bilayer, and inside is that the closure vesica of water phase is known as liposome, the structure of liposome
Similar biomembrane, therefore also known as artificial membrane, size, can be in the water phase of liposome and film from tens nanometers to tens micron
Wrap up many kinds of substance.The double membrane structure for the liposome being made of natural film component is in principle as natural fine after birth, usually
In order to improve the chemistry and biological shapes of liposome, liposome can also be made of artificial synthesized lipid completely.Currently, lipid
The research of body is concentrated mainly on four fields: the research of analogue membrane, the controlled release of drug and intracorporal target administration, skin and
The matrix of the manufactured goods such as cosmetics, gene and other physiological activators are to intracellular transhipment.Recently as biology
The continuous development of technology, the preparation process gradual perfection of liposome.Liposome is suitable for degradation in organism, non-toxic and nothing is exempted from
Epidemic focus has targeting as pharmaceutical carrier, to reduce drug dose, reduce toxicity, reduces side effect, therefore lipid
Body packaging medicine oneself be more and more taken seriously and be used widely.In daily use chemicals matrix application aspect, essence class skin-protection product
In usually using liposome as carrier, wrap up the transdermal skin of essence, to reach anti-aging, crease-resistant, moisturizing, whitening, despeckle
Effect.Prior art CN108542820A discloses a kind of skin sorbefacient, skin matrix and its preparation method and application,
But liposome matrix in the prior art only has unidirectional Transdermal absorption effect, essence enters generated metabolism after skin
Object also needs slowly to excrete by natural mechanism, be easy to cause and deposits under skin epidermis, influences using effect, even damages
Hurt skin.
Therefore, a kind of Transdermal absorption skin matrix with two-way function is studied for improving the using effect of skin matrix
It has very important significance.
Summary of the invention
It is only unidirectional absorb the technical problem to be solved by the present invention is to overcome the Transdermal absorption of existing liposome skin matrix
Defect and deficiency, a kind of Transdermal absorption skin matrix of two-way function is provided.
The object of the present invention is to provide a kind of preparation methods of the Transdermal absorption skin matrix of two-way function.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of Transdermal absorption skin matrix of two-way function, the Transdermal absorption skin matrix include essence Transdermal absorption
Liposome and skin inducing diaphoresis element liposome, wherein including plant extract elite, partial size in the essence Transdermal absorption liposome
It include ginger extract in the skin inducing diaphoresis element liposome for 50~200nm, partial size is 200~1000nm.
Plant extract fine Huawei in Transdermal absorption skin matrix of the invention can be used for the plant extract elite of skin care,
It may include folium artemisiae argyi, green tea, Blumea balsamifera, rose, dandelion, ginseng, mulberry leaf, kuh-seng, Cortex Phellodendri, Rhizoma Atractylodis Macrocephalae, Radix Astragali, Radix Angelicae Sinensis, red
Chinese herbaceous peony etc. skims the cream off milk.
Facial treatment essence is wrapped in liposome by existing Transdermal absorption liposome matrix, and essence enters the metabolism after skin
Product cannot exclude in time, need to exclude by slowly giving birth to old metabolism, cause deposition damage to skin, of the invention includes essence
The skin matrix of magnificent element Transdermal absorption liposome and skin inducing diaphoresis element liposome not only can be very good to load with facial treatment essence, reach
Good skin effect, but also essence metabolite can be discharged in time with two-way function, avoid deposition and skin damage.
The principle of the present invention is: using after the product, the transdermal liposome of the essence of small particle is quick by transdermal effect
Going deep into skin, directly acts on skin corium, large-sized skin inducing diaphoresis element liposome is attached to skin surface, slow release,
Under the action of skin inducing diaphoresis element, fleshy exterior is discongested, is promoted sweating, so that the metabolin of transdermal essence be excreted, reaches double
To the purpose of effect.
Skin inducing diaphoresis element liposome of the invention contains ginger extract, and for liposomal particle size in 200-1000nm, absorption is slower,
The gingerols ingredient such as gingerol rich in, ginger brain in ginger extract stimulates epidermis nerve endings into after epidermis, emerging
It puts forth energy capillary abundant in skin corium, expansion blood vessel accelerates blood circulation to generate heating functioin, accelerates blood circulation, take away skin
A large amount of metabolite in skin, skin temperature increase, and while the expansion of epidermis pore is radiated, take away skin corium moisture, moisture
And residual metabolism product in skin, clean sebaceous glands, sweat gland.The radiation such as ultraviolet light will increase the free radical in human skin, from
It human body cell can be encroached on by base generates and cause to decline factor M DA, the cause factor M DA that declines further encroaches on cell and generates lipofuscin, lipofuscin
Precipitating ultimately forms color spot precipitating, and senile plaque, gingerol has oxidation resistant effect, has certain scavenging hydroxyl and oxygen certainly
By the ability of base, fights lipofuscin and generate.
The particle size of liposome is to influence one of Transdermal absorption efficiency factor, when liposomal particle size is excessive or too small all can
The transporting power and skin for influencing liposome absorb.
Preferably, the partial size of the essence Transdermal absorption liposome is 50~150nm.
Preferably, the partial size of the skin inducing diaphoresis element liposome is 200~800nm.
It is highly preferred that the partial size of the essence Transdermal absorption liposome is 50~150nm, the skin inducing diaphoresis element lipid
The partial size of body is 400~800nm.Such as it can be 50nm, 100nm or 150nm that the partial size of essence Transdermal absorption liposome, which is,
The partial size of skin inducing diaphoresis element liposome can be 400nm, 600nm or 800nm.
It preferably, also include liposome, support in the essence Transdermal absorption liposome and skin inducing diaphoresis element liposome
Agent, antioxidant, solubilizer and stabilizer.
The wherein effect of proppant are as follows: proppant is added for freeze-drying operation, and liposome in freeze-drying operating process is prevented
It collapses, causes moisture drying incomplete.Liposome composition finished product of the invention is emulsion, and emulsion products facilitate fortune after being lyophilized
Defeated and preservation, freeze-dried powder can be transported carry out recovery operation again elsewhere, save transportation cost.
The effect of antioxidant are as follows: constitute containing unsaturated fatty acid chain in the main component molecule of liposome membrane, easily
Oxydrolysis causes membrane fluidity reduces, container leaks etc., and anelasticity is deteriorated, and generates aggregate and precipitate, and antioxidant energy is added
It effectively prevent lipid oxidation to destroy.
The effect of solubilizer are as follows: increase the solubility of microsolubility or insoluble substance.
The effect of stabilizer are as follows: the size of the current potential of increase solution viscosity or change liposome and positive and negative, increase lipid
The stability of body.
Preferably, the mass percent of the raw material are as follows: ginger extract 1~5%, plant extract elite 10~20%, rouge
Plastid 10~20%, proppant 1~3%, antioxidant 0.01~0.10%, solubilizer 5~15% and stabilizer 5~15%,
Surplus is water.
Preferably, the gingerol component content in ginger extract of the invention is 20%-30%, ginger extract in raw material
Mass percent is 2.5~5%.Gingerol must reach a certain concentration in liposome composition and just be able to achieve the effect, dense
Spend it is low cannot excited capillary generate heating functioin, the excessive irritation of concentration is too strong.
Preferably, the mass percent of the raw material are as follows: ginger extract 5%, plant extract elite 15%, liposome
18%, proppant 2%, antioxidant 0.06%, 15 parts of solubilizer and stabilizer 15%, surplus are water.
Preferably, the liposome is one or more of lecithin, cephalin, soybean lecithin.
Preferably, the proppant is one or more of cholesterol, stigmasterol and cupreol.
Preferably, the antioxidant is one or more of vitamin E, vitamin C, superoxide dismutase.
Preferably, the solubilizer is poloxamer, Tween 80, sorb alcohol ester, Macrogol 4000 and Macrogol Ester
One or more of fat acid glyceride.
Preferably, the stabilizer is one or more of glycerol, propylene glycol and butanediol.
A kind of preparation method of the Transdermal absorption skin matrix of two-way function, includes the following steps:
S1. it by lecithin, proppant, solubilizer, antioxidant, mixes and is sufficiently stirred under the conditions of 55~60 DEG C of temperature
To homogeneous oil phase, 10~15min is kept the temperature；
S2. claim stabilizer, ginger extract to be dissolved in pure water, be warming up to 50~60 DEG C, stir as homogeneous aqueous phase, heat preservation 10~
15min；
S3. by the oil prepared in S1 mutually be pre-mixed in the water phase that is prepared in S2, be uniformly mixed, at 50~60 DEG C
10~15min is kept the temperature, colostric fluid is made；
S4. colostric fluid is carried out under 40~200MPa pressure high-pressure homogeneous circular treatment to it is transparent or semitransparent when take
Out, cooled to room temperature obtains skin inducing diaphoresis element liposome；
S5. essence Transdermal absorption liposome is prepared according to the step of S1~S4；
S6. skin inducing diaphoresis element liposome and essence Transdermal absorption liposome are mixed, is slowly stirred in the same direction
It is even, obtain the Transdermal absorption skin-protection product of two-way function.
During liposome preparation, phosphatide phase transition temperature is a highly important parameter, and film forming is that preparation is formed most
Important factor, film-forming temperature then have to the phase transition temperature higher than phosphatide.The phase transition temperature of lecithin is 50 degree, prepares lipid
Temperature must reach phase transition temperature or more when body, can just make liposome bilayers arrangement close, enhance liposome stability.
The isothermal holding of S1, S2 and S3 of the present invention are for the stability of enhancing product, the high-pressure homogeneous pressure in S4
Power is primarily to control the dispersion size of liposome particles, and within the scope of certain pressure, pressure is bigger, liposome particles dispersion
It obtains smaller
Preparation method of the invention is easy to use, and properties of product are stablized, and is suitable for actual production.
Compared with prior art, the beneficial effects of the present invention are:
The present invention provides a kind of Transdermal absorption skin matrix of two-way function, skin matrix includes that can carry out to skin
The essence Transdermal absorption liposome and essence Absorption And Metabolism product is promoted to be discharged in time that deep layer is nourished, avoid deposition and skin
The skin inducing diaphoresis element liposome of damage, changes original single effect mechanism, realizes the two-way Transdermal absorption of skin matrix,
Residual metabolism product in skin corium moisture and skin can also be taken away simultaneously, cleans sebaceous glands, sweat gland, inhibit free radical bring
The infringement of the factor M that declines DA has the synthesis skin care effect of efficiently nourishing, whitening agent anti-aging.Preparation method provided by the invention
It is simple to operation, it is suitable for industrialized production, can be widely applied to the production of skin matrix.
Specific embodiment
The present invention is further illustrated With reference to embodiment, but embodiment the present invention is not done it is any
The restriction of form.Unless otherwise indicated, source chemicals used in the embodiment of the present invention are the source chemicals routinely bought.
Examples 1 to 9
A kind of Transdermal absorption skin matrix of two-way function, including essence Transdermal absorption liposome and skin inducing diaphoresis element rouge
Plastid, wherein see Table 1 for details for the particle size parameters of essence Transdermal absorption liposome and skin inducing diaphoresis element liposome.
Table 1
| Serial number | Essence Transdermal absorption liposome/nm | Skin inducing diaphoresis element liposome/nm |
| Embodiment 1 | 50 | 200 |
| Embodiment 2 | 200 | 1000 |
| Embodiment 3 | 100 | 600 |
| Embodiment 4 | 150 | 1000 |
| Embodiment 5 | 150 | 800 |
| Embodiment 6 | 100 | 800 |
| Embodiment 7 | 100 | 400 |
| Embodiment 8 | 50 | 400 |
| Embodiment 9 | 150 | 600 |
Embodiment 10~15
A kind of Transdermal absorption skin matrix of two-way function, including essence Transdermal absorption liposome and skin inducing diaphoresis element rouge
Plastid, wherein the partial size of essence Transdermal absorption liposome and skin inducing diaphoresis element liposome is same as Example 1, by the following raw material
Be prepared: object skims the cream off milk, ginger extract, liposome, proppant, antioxidant, solubilizer and stabilizer, each raw material component
Specific mass percent be shown in Table 2.
Table 2
The Transdermal absorption skin matrix of the two-way function of above-described embodiment the preparation method comprises the following steps:
S1. it by lecithin, proppant, solubilizer, antioxidant, mixes and is stirred well under the conditions of 60 DEG C of temperature
Even oil phase, keeps the temperature 15min；
S2. claim stabilizer, ginger extract to be dissolved in pure water, be warming up to 60 DEG C, stir as homogeneous aqueous phase, heat preservation 10min；
S3. by the oil prepared in S1 mutually be pre-mixed in the water phase that is prepared in S2, be uniformly mixed, kept the temperature at 50 DEG C
Colostric fluid is made in 15min；
S4. colostric fluid is carried out under 100MPa pressure high-pressure homogeneous circular treatment to it is transparent or semitransparent when taking-up, from
It is so cooled to room temperature, obtains skin inducing diaphoresis element liposome；
S5. essence Transdermal absorption liposome is prepared according to the step of S1~S4；
S6. skin inducing diaphoresis element liposome and essence Transdermal absorption liposome are mixed, is slowly stirred in the same direction
It is even, obtain the Transdermal absorption skin-protection product of two-way function.
Comparative example 1
A kind of Transdermal absorption skin matrix of two-way function, including essence Transdermal absorption liposome and skin inducing diaphoresis element rouge
Plastid, wherein the partial size of essence Transdermal absorption liposome is 250nm and the partial size of skin inducing diaphoresis element liposome is 800nm.
Comparative example 2
A kind of Transdermal absorption skin matrix of two-way function, including essence Transdermal absorption liposome and skin inducing diaphoresis element rouge
Plastid, wherein the partial size of essence Transdermal absorption liposome is 40nm and the partial size of skin inducing diaphoresis element liposome is 800nm.
Comparative example 3
A kind of Transdermal absorption skin matrix of two-way function, including essence Transdermal absorption liposome and skin inducing diaphoresis element rouge
Plastid, wherein the partial size of essence Transdermal absorption liposome is 50nm and the partial size of skin inducing diaphoresis element liposome is 150nm.
Comparative example 4
A kind of Transdermal absorption skin matrix of two-way function, including essence Transdermal absorption liposome and skin inducing diaphoresis element rouge
Plastid, wherein the partial size of essence Transdermal absorption liposome is 50nm and the partial size of skin inducing diaphoresis element liposome is 1050nm.
As a result it detects
Skin pore detection, skin oil and fat secretion are carried out to the Transdermal absorption skin matrix of the embodiment of the present invention and comparative example
Amount detection.
1, tested crowd: 60 healthy volunteers, the age between 18-35 one full year of life, Oily, facial skin pore
It is coarse.
2, test method
(1) test method of skin pore:
The product of embodiment and comparative example is applied to the coarse concentration position of volunteer face pore, applying amount 2mg/cm
Wait 3min to allow and is dried out naturally by sample, using Roboskin analyzer, count respectively using before product, using product 3 days,
Pore area after 7 days, 15 days, 21 days is analyzed by using data before and after product, improves the coarse effect of pore with pore
Flat-profile view μm2It indicates, improvement rate is bigger, illustrates that the coarse effect of improvement pore of given the test agent is more obvious.
(2) skin surface fat secretion amount test method:
The product of embodiment and comparative example is uniformly applied to volunteer's skin surface, applying amount 2mg/cm2, wait 2
Hour, it is covered in skin surface with oil-Absorbing Sheets after skin surface sweat is dry, permeability changes after oil-Absorbing Sheets oil suction pass through test
The variation of epidermis fat secretion amount can be obtained in the light transmittance variation of oil-Absorbing Sheets, count respectively using before product, using product 3 days, 7
It, 15 days, the fat secretion amount after 21 days, oil-Absorbing Sheets are impregnated with to the light transmittance size being completely dried completely and are divided into 10 grades
Not, numerical value is higher, and fat secretion is bigger；
Data analysis persistently is carried out with the above test method using after 1 month, test result is as follows shown in table 3 and 4.
The test result μm of the improvement skin pore of table 32
4 skin oil and fat secretory volume of table
It is obtained by table 3,4 data comparison of table, big using preceding 7 days fat secretion amounts, fat secretion amount gradually decreases after 7 days
Tend to be balanced；The partial size of essence Transdermal absorption liposome is 50~150nm, the partial size of skin inducing diaphoresis element liposome is 400~
Effect is best when 800nm；
It is proved by user experience staining effect, is obviously generated heat using skin after this product, skin surface sweat and grease
Secretion increases.Skin pore zooms in after a period of use, and fat secretion is balanced, and acne is reduced, hence it is evident that decline color spot is eliminated dark
Sore mark.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claims in the present invention within the spirit and principle of invention
Protection scope within.
Claims (10)
1. a kind of Transdermal absorption skin matrix of two-way function, which is characterized in that the Transdermal absorption skin matrix includes essence
Plain Transdermal absorption liposome and skin inducing diaphoresis element liposome, wherein including plant extract in the essence Transdermal absorption liposome
Essence, partial size are 50 ~ 200nm, include ginger extract in the skin inducing diaphoresis element liposome, and partial size is 200 ~ 1000nm.
2. Transdermal absorption skin matrix as described in claim 1, which is characterized in that the grain of the essence Transdermal absorption liposome
Diameter is 50-150nm.
3. Transdermal absorption skin matrix as described in claim 1, which is characterized in that the partial size of the skin inducing diaphoresis element liposome is
200-800nm。
4. Transdermal absorption skin matrix as described in claim 1, which is characterized in that the grain of the essence Transdermal absorption liposome
Diameter is 50-150nm, and the partial size of the skin inducing diaphoresis element liposome is 400-800nm.
5. Transdermal absorption skin matrix as described in claim 1, which is characterized in that the essence Transdermal absorption liposome and flesh
It also include liposome, proppant, antioxidant, solubilizer and stabilizer in skin inducing diaphoresis element liposome.
6. Transdermal absorption skin matrix as claimed in claim 5, which is characterized in that the mass percent of the raw material are as follows: ginger mentions
Take object 1 ~ 5%, plant extract elite 10 ~ 20%, liposome 10 ~ 20%, proppant 1 ~ 3%, antioxidant 0.01 ~ 0.10%, solubilizer
5 ~ 15% and stabilizer 5 ~ 15%, surplus be water.
7. Transdermal absorption skin matrix as claimed in claim 6, which is characterized in that the mass percent of the raw material are as follows: ginger mentions
Take object 5%, plant extract elite 15%, liposome 18%, proppant 2%, antioxidant 0.06%, 15 parts of solubilizer and stabilizer
15%, surplus is water.
8. the Transdermal absorption skin matrix as described in claim 1 ~ 7 any one, which is characterized in that the liposome is lecithin
One or more of rouge, cephalin, soybean lecithin.
9. the Transdermal absorption skin matrix as described in claim 1 ~ 7 any one, which is characterized in that the proppant is solid for gallbladder
One or more of alcohol, stigmasterol and β-sitosterol.
10. a kind of preparation method of the Transdermal absorption skin matrix of two-way function, which comprises the steps of:
S1. it by lecithin, proppant, solubilizer, antioxidant, mixes and is stirred well under the conditions of 55~60 DEG C of temperature
Homogeneous oil phase keeps the temperature 10~15min；
S2. claim stabilizer, ginger extract to be dissolved in pure water, be warming up to 50~60 DEG C, stir as homogeneous aqueous phase, heat preservation 10~
15min；
S3. by the oil prepared in S1 mutually be pre-mixed in the water phase that is prepared in S2, be uniformly mixed, protected at 50~60 DEG C
10~15min of temperature, is made colostric fluid；
S4. colostric fluid is carried out under 40~200MPa pressure high-pressure homogeneous circular treatment to it is transparent or semitransparent when taking-up, from
It is so cooled to room temperature, obtains skin inducing diaphoresis element liposome；
S5. essence Transdermal absorption liposome is prepared according to the step of S1 ~ S4；
S6. skin inducing diaphoresis element liposome and essence Transdermal absorption liposome are mixed, are slowly stirred in the same direction uniformly,
Obtain the Transdermal absorption skin-protection product of two-way function.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114504513A (en) * | 2022-01-07 | 2022-05-17 | 北京理工大学重庆创新中心 | Composite probiotic matrine coconut oil liposome and preparation method and application thereof |
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| CN102895189A (en) * | 2012-10-09 | 2013-01-30 | 天津芸熙生物技术有限公司 | Gingerol liposome and preparation method thereof |
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| CN108143669A (en) * | 2018-03-06 | 2018-06-12 | 广州星愉贸易有限公司 | A kind of phalacrosis prevention and hair generation shampoo and preparation method thereof |
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| KR100948204B1 (en) * | 2009-06-23 | 2010-03-16 | 주식회사지피에이코리아 | Composition for improving condition of hair and scalp containing a herb extracts mixture stabilized by liposome |
| CN102895189A (en) * | 2012-10-09 | 2013-01-30 | 天津芸熙生物技术有限公司 | Gingerol liposome and preparation method thereof |
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