KR102226844B1 - Cosmetic compositions containing gold particles for treating acne - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving acne, and in the composition of the composition: a magnetic substance, a dielectric particle layer, a metal-containing coating layer, a gold nanoparticle layer, and a gold particle consisting of a PEG cover layer as an active ingredient. do. At this time, the gold particles of the present invention have a magnetic nanoparticle having a diameter of 1 nm to 1,000 nm, a dielectric particle layer having a particle diameter of 80 nm to 120 nm, a metal-containing coating layer having a thickness of 10 nm to 30 nm, and the sum of 50 nm to 250 nm. The cosmetic composition is characterized in that it contains 1mg/mL to 15mg/mL with respect to the total weight of the cosmetic composition.
Accordingly, the present invention uses micro gold particles (magnetic metal nanocomposites) to form a cosmetic composition for improving acne, so that micro gold particles are useful for diagnosing and improving cellular diseases, and at the same time, excellent target orientation and improvement for specific cells. As it is effective, it has low toxicity to the human body, has excellent effects such as sebaceous gland destruction and antibacterial action, and is useful for improving acne without side effects on the skin. Product stability is excellent, such as being able to be used for hand wash, etc.

Description

Cosmetic compositions containing gold particles for treating acne {Cosmetic compositions containing gold particles for treating acne}

The present invention relates to a cosmetic composition for improving acne, and more specifically, by forming a cosmetic composition for improving acne using micro gold particles (magnetic metal nanocomposite), micro gold particles are used in diagnosing and improving cell diseases. It is useful at the same time as it exhibits excellent target orientation and improvement effect for specific cells, so it has low toxicity to the human body, has excellent efficacy effects such as sebaceous gland destruction and antibacterial action, and is useful for improving acne without side effects on the skin. It relates to a cosmetic composition containing gold particles for improving acne, which has excellent product stability, such as being used for serum, essence, mask pack, cream, powder, hand wash, and the like.

In recent years, as the life expectancy has increased due to the development of medical technology and the standard of living has been improved due to the rise of national income, interest in health and appearance of modern people is increasing, and a lot of attention has been paid to improving the appearance. In modern times, industries related to skin beauty such as wrinkle management, whitening, atopy, and acne management are growing rapidly.

On the other hand, acne occurs mainly during puberty, especially in hormonal changes, and is a pilosebaceous disease characterized by comedones, papules, pustules, nodules, etc. Recently, the incidence of acne is increasing even in adults. In the West, about 79 to 95% of teenage adolescents suffer from acne disease, and in particular, about 40 to 50 million people in the United States are known as acne patients. Acne is not limited to adolescents, but also occurs widely in adults, and some studies report that 40% of the male population and 54% of the female population among adults over 25 years of age have acne disease.

To treat such acne, use an applied drug or use a medicine you eat. Antibacterial agents, antibiotics, and exfoliating agents are used as medicines, and antibiotics, corticosteroids, and sebum secretion inhibitors are used as medicines to be eaten. However, in the case of the applied drug, it irritates the skin and develops side effects and resistance when used for a long period of time.

As such, various methods have been studied to treat acne. As a related prior art, Korean Patent Publication No. 1995-0008762 (priority document 1), Korean Patent Publication No. 10-0147332 (priority document 2), Korea Registered Patent Publication No. 10-0491746 (Prior Document 3) and the like are known.

Prior Literature 1 describes Propionibacterium acnes, which is a mixture of plant extracts obtained from myrrh, five baeja, gaja, jeongbaek leaves, and ginkgo leaves. Disclosed is a cosmetic composition having an effective effect on acne by inhibiting the growth of ).

Prior Literature 2 is a raw material that contains 30-50% by weight (wt%) of gold, silver, yeongyo, gosam, and hyeonsam, 55-65% by weight (wt%) of own plant, and 1-5% by weight (wt%) of Sambaekcho. 1.3-butylene glycol [1.3-buthylene glychol (1.3-BG H2) 10/90 v/v)] was added 4-5 times the volume of the raw material, and heated at 55-70° C. for 1.5-2.5 hours 1 After the primary heating, the secondary heating at 100-120° C. for 3-5 hours is performed, and then hot water is extracted under reduced pressure and filtered with filter paper to obtain a filtrate, treated with activated carbon, and concentrated under reduced pressure to reduce pressure. A concentrated solution was obtained, and the concentrated solution under reduced pressure was eluted and separated using water or ethanol as a mobile phase by column chromatography in which the weight ratio of Flonisil/zeolite (Flonisil/zeolite) was 3:1, and the water content was 50-60% by volume. It is characterized in that a 0.1% volume ratio of each of vitamin biwon (vitamine B1), vitamin B2 (vitamine B2), vitamin vitamine (vitamine B6), and retinoic acid is mixed with an extract of (V%) Disclosed is an extract composition for the treatment of acne extracted from natural products.

Prior Document 3 discloses a composition for external application for the prevention and treatment of acne, characterized in that it contains 0.01 to 10% by weight of the extract obtained by filtering and concentrating the extract of Mohwangryeon, based on the dry state, after extracting the Mohwangryeon with an aqueous ethanol solution.

However, the above-described prior literature has a problem in that its potency varies depending on the plant cultivation conditions, collection time, collection site and extraction method, etc., and it is difficult to stably obtain a large amount compared to the treatment with a chemical agent.

In addition, there are many external drugs for acne treatment, and antibiotics such as benzoyl peroxide or mycin are used, or exfoliating agents such as salicylic acid are used. Tretinoin is used in cream or gel formulations, and benzoyl peroxide is used for inflammatory acne because it has a strong antibacterial action against acne bacteria. As antibiotics, clindamycin and erythromycin are used. However, these antimicrobial agents and antibiotics may cause side effects on the skin, and if used continuously for a long period of time, there is a disadvantage that resistance may occur or may be annoying to the skin.

On the other hand, salicylic acid is the most widely used cosmetic ingredient for acne treatment, and it is widely used for the purpose of preventing clogging of skin pores and alleviating acne symptoms by speeding up skin regeneration without burdening the skin even after long-term use. Has been. However, salicylic acid alone relieves the symptoms of acne and is insufficient to normalize the skin. Therefore, when used as a general therapeutic drug, antibiotics are added to reduce sterilization and inflammation symptoms. In addition, salicylic acid irritates the skin due to the skin exfoliation effect, and has a low solubility in water, so that an excessive amount of alcohol must be prescribed, which causes the skin to dry out. As medicines to eat, sebum secretion inhibitors such as tetracycline, isotretinoin, adrenocorticotropic hormone and estrogen are used. Since the medicine you eat works on the whole body, you should be careful about the occurrence of side effects.

Under this background, the present inventors have researched to find a cosmetic composition with excellent skin-related efficacy and safety. As a result, micro gold particles, that is, magnetic metal nanocomposites, are useful in diagnosing and improving cellular diseases, and at the same time exhibiting excellent target orientation for specific cells. It has been confirmed that when light energy of a specific wavelength is supplied from the outside, it is converted into constant heat energy to generate heat, and the generated heat has effects such as destruction of sebaceous glands and antibacterial action, which are the causes of acne.

Korean Patent Publication No. 1995-0008762 "Cosmetic composition having an effective effect on acne" (Announcement date: 1995. 08. 08.) Korean Patent Publication No. 10-0147332 "Extracted composition for improving acne from natural substances" (Registration date: 1998. 05. 16.) Korean Patent Publication No. 10-0491746 "A composition for preventing and treating acne containing Mohwangryeon extract" (Registration date: May 18, 2005)

An object of the present invention for fundamentally improving the conventional problems as described above is to form a cosmetic composition for improving acne using micro gold particles (magnetic metal nanocomposites), so that micro gold particles diagnose and improve cellular diseases. At the same time, it has excellent target orientation and improvement effect on specific cells, so it has low toxicity to the human body, has excellent efficacy effects such as sebaceous gland destruction and antibacterial action, and is useful for acne improvement without side effects on the skin. , Serum, essence, mask pack, cream, powder, hand wash, etc. It is intended to provide a cosmetic composition containing gold particles for improving acne with excellent product stability.

The present invention for achieving the above object is, in the cosmetic composition for improving acne: a magnetic substance, a dielectric particle layer, a metal-containing coating layer, a gold nanoparticle layer, and a gold particle consisting of a PEG cover layer as an active ingredient, the gold particle Is characterized in that the diameter of the magnetic material is 1nm~1,000nm, the particle diameter of the dielectric particle layer is 80nm~120nm, the thickness of the metal-containing coating layer is 10nm~30nm, and the sum is 50nm~250nm.

delete

In addition, according to the present invention, the cosmetic composition is characterized in that it contains 1mg/mL to 15mg/mL with respect to the total weight of the cosmetic composition.

In addition, the cosmetic composition of the present invention is selected from the group consisting of skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, hand wash. It is characterized in that it is prepared in any one formulation.

On the other hand, prior to this, terms or words used in the present specification and claims should not be construed as being limited to their usual or dictionary meanings, and the inventors have devised the concept of terms in order to explain their own invention in the best way. Based on the principle that it can be defined appropriately, it should be interpreted as a meaning and concept consistent with the technical idea of the present invention. Therefore, the embodiments described in the present specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention, and do not represent all of the technical spirit of the present invention. It should be understood that there may be equivalents and variations.

As described in the above configuration and action, the cosmetic composition including gold particles for improving acne according to the present invention uses micro gold particles (magnetic metal nanocomposite) to form a cosmetic composition for improving acne, so that the micro gold particles are It is useful for diagnosing and improving cellular diseases, and at the same time exhibiting excellent target orientation and improvement effect for specific cells, so it has low toxicity to the human body, has excellent efficacy effects such as sebaceous gland destruction and antibacterial action, and is useful for improving acne without side effects on the skin. It provides excellent product stability and can be used for lotion, skin, serum, essence, mask pack, cream, powder, hand wash, etc.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

All technical terms used in the present invention, unless otherwise defined, have the following definitions and correspond to the meaning as commonly understood by those of ordinary skill in the relevant fields of the present invention. In addition, although preferred methods or samples are described in the present specification, those similar or equivalent are included in the scope of the present invention.

And the contents of all publications described as references in this specification are introduced into the present invention. The term about is 30, 25, 20, 25, 10, 9, 8, 7, 6, 5, 4, or 30, 25, 20, 25, 10, 9, 8, 7, 6, 5, 4, for reference amount, level, value, number, frequency, percent, dimension, size, amount, weight or length. It means an amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length, varying by 3, 2 or 1%.

The present invention proposes a cosmetic composition for improving acne. In particular, the target is to apply gold particles composed of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nanoparticle layer, and a PEG cover layer to a cosmetic composition for improving acne, but is not limited thereto.

Here, in the cosmetic composition for improving acne according to the present invention, it is characterized in that it comprises gold particles consisting of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nano particle layer, and a PEG cover layer as an active ingredient.

Meanwhile, the gold particles of the present invention are composed of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nano particle layer, and a PEG cover layer, wherein the magnetic material is a magnetic nanoparticle or a magnetic nanocluster that is a group thereof, and is dispersed in the particle or It exists in the form of a core, and the diameter of the magnetic body is formed from 1 nm to 1,000 nm. The dielectric particle layer contains the magnetic material and is selected from the group consisting of silica, titania, polymer particles, alumina, and mixtures thereof, and the dielectric particle layer has a particle diameter of 80 nm to 120 nm.

In addition, the metal-containing coating layer of the present invention contains a metal selected from the group consisting of Au, Ag, and Pt while being formed on the surface of the dielectric particles, and the thickness of the metal-containing coating layer is formed in a range of 10 nm to 30 nm. The gold nanoparticle layer is coated on the surface of the dielectric particle, and the PEG cover layer is coated on the surface of the dielectric particle again.

Meanwhile, the gold particles of the present invention are generally referred to as metal nanocomposites, and are composed of spherical dielectric core nanoparticles and a thin metal film surrounding the core. The metal nanocomposite can absorb electromagnetic waves by surface plasmon resonance, and the absorbed electromagnetic waves collectively vibrate conductive electrons in the metal film to generate heat. The wavelength range of the electromagnetic wave absorbed by the metal nanocomposite and the corresponding heat generation can be easily controlled by adjusting the type of metal used, the dielectric core nanoparticles, and the thickness of the metal film. In addition, although the degree of electromagnetic waves varies depending on the wavelength, they have a characteristic capable of penetrating living tissues to some extent, and such characteristics of electromagnetic waves are being applied as a tool for diagnosing diseases in clinical practice. Based on the properties of the metal nanocomposite and the electromagnetic wave, studies for applying the metal nanocomposite to drug delivery or disease treatment have been continuously conducted in the art.

These gold particles consist of a total of 50 nm to 250 nm of a magnetic substance, a dielectric particle layer, a metal-containing coating layer, a gold nano particle layer, and a PEG cover layer, and these gold particles are 1 mg/mL to 15 mg/mL based on the total weight of the cosmetic composition. To prepare a cosmetic composition containing, more preferably, the gold particles will be preferably contained in 4mg / mL ~ 10mg / mL with respect to the total weight of the cosmetic composition. This is 4 mg/mL for the mild version and approximately 10 mg/mL for the strong version. That is, when the content of the gold particles is less than 4mg/mL, the efficacy is insignificant, and when it exceeds 10mg/mL, there is a problem in the safety and stability of the formulation, and it is not economical.

Here, the method for producing gold particles of the present invention is Korean Patent Publication No. 10-0924786, which is the right of the present invention well known in the art, "magnetic metal nanocomposite for diagnosis and treatment" (registration date: 2009. 10. 27. ), but will not be limited thereto.

On the other hand, the cosmetic composition of the present invention is selected from the group consisting of skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, hand wash. It is characterized in that it is prepared in any one formulation. That is, the cosmetic composition of the present invention can be prepared in any formulation commonly prepared in the art, for example, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing , Oil, powder foundation, emulsion foundation, wax foundation, and may be formulated as a spray, but is not limited thereto. That is, in more detail, skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, hand wash.

In addition, cosmetics prepared with a cosmetic composition containing as an active ingredient of the gold particles of the present invention can be prepared in the form of a general emulsified formulation and a solubilized formulation. Cosmetics in emulsified form include nutrient lotion, cream, and essence, and cosmetic products in solubilized form include softening lotion.

In addition, by containing a dermatologically acceptable medium or base in addition to the cosmetics containing the active ingredient of the gold particles of the present invention, it can be prepared in the form of an adjuvant that can be applied topically or systemically used in the field of dermatology. . Suitable cosmetic formulations include, for example, solutions, gels, solid or paste anhydrous products, emulsions obtained by dispersing the oil phase in an aqueous phase, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes), nonionic It may be provided in the form of a vesicle dispersant, a cream, skin, lotion, powder, ointment, spray or conceal stick.

In addition, the cosmetic composition of the present invention includes fatty substances, organic solvents, solubilizers, thickeners and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, and interfacial agents in addition to the active ingredients of gold particles. Activators, water, ionic or nonionic emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic activators, lipid vesicles or common in cosmetics It may contain adjuvants commonly used in the field of cosmetology or dermatology, such as any other ingredients used as.

And the above ingredients may be introduced in an amount generally used in the field of dermatology. Products to which the cosmetic composition of the present invention can be added include, for example, astringent lotion, softening lotion, nutrient lotion, various creams, essences, packs, and cosmetics such as foundations, and cleansing, face wash, soap, treatments, and beauty liquids. Etc. Specific formulations of the cosmetic composition of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, It includes formulations such as soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder, and eye shadow.

Specifically, if the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or Zinc oxide or the like may be used.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Sex cellulose, aluminum metahydroxide, bentonite, agar or tracanth, and the like can be used.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / May contain propellants such as butane or dimethyl ether. When the formulation of the present invention is a surfactant-containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether Sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters may be used.

When the cosmetic composition of the present invention is a soap, a cleansing formulation containing a surfactant, or a cleansing formulation containing no surfactant, it may be applied to the skin and then wiped off, removed, or washed off with water. As a specific example, the soap is liquid soap, powder soap, solid soap and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel and cleansing pack, and the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotion, cleansing water, and cleansing gel, but is not limited thereto.

On the other hand, the cosmetic method of the present invention refers to all cosmetic methods using the cosmetic composition of the present invention. That is, all methods known in the art using the cosmetic composition belong to the cosmetic method of the present invention. The cosmetic composition of the present invention may be used alone or in duplicate, or may be used in conjunction with other cosmetic compositions other than the present invention. In addition, the cosmetic composition according to the present invention may be used according to a conventional method of use, and the number of times of use thereof may be varied according to a user's skin condition or taste.

Hereinafter, examples and manufacturing examples will be described in detail to aid understanding of the present invention. However, the following Examples and Experimental Examples are merely illustrative of the contents of the present invention, and the scope of the present invention is not limited to the following Examples and Experimental Examples. Examples and preparation examples of the present invention are provided to more completely describe the present invention to those of ordinary skill in the art.

(1) A cosmetic composition for improving acne, that is, a formulation example of a lotion among cosmetics containing the active ingredient of gold particles was prepared as shown in Table 1 below.

(2) A cosmetic composition for improving acne, that is, a formulation example of a cream among cosmetics containing the active ingredient of gold particles was prepared as shown in Table 2 below.

(3) A cosmetic composition for improving acne, that is, a formulation example of an essence among cosmetic compositions containing the active ingredient of gold particles was prepared as shown in Table 3 below.

(4) Cytotoxicity evaluation

Using the cosmetic composition for improving acne prepared in Formulation Examples 1 to 3 according to the present invention, cytotoxicity in HaCaT cells and HDF-Ncells was measured (see Table 4 below). HaCaT cells were well in 96 well plates. At a concentration of 5×104 cells per well, HDF-Ncells were dispensed in a 96 well plate at a concentration of 6×103 cells per well, and then cultured for 24 hours under cell culture conditions. After removing the medium and washing with DPBS, after maintaining the starvation state for 12 hours, a test solution and a new medium (excluding media supplement) were added and cultured for 24 hours. In addition, after removing the sample solution and medium and washing with PBS, in order to measure the viability of cells, the WST-1 reaction solution was diluted 1/10 in a medium excluding supplement and treated with 100 µl per well for 1 hour reaction. After that, the absorbance was measured at 450 nm. As a result, when the concentration of up to 100 ppm in HaCaT cells and HDF-N cells, Formulation Example 1 shows 99.4% and 98.6% survival rates, Formulation Example 1 shows 99.4% and 98.6% survival rates, and Formulation Example 2 is 99.5 % And 98.4% survival rates, and Formulation Example 3 showed the survival rates of 99.6% and 98.2%, confirming the results shown in Table 4.

As such, it was confirmed that the cosmetic composition for improving acne according to the present invention, that is, among the cosmetics included as an active ingredient of gold particles, does not exhibit cytotoxicity, and thus has excellent skin stability.

(5) Effect of destruction of sebaceous glands in pores due to photothermal effect

The occurrence of acne has a combination of causes. In particular, due to the excess of male hormones, the secretion of the sebaceous glands becomes active and the hair follicles are clogged, forming comedones, the basic lesion of acne. Therefore, suppressing the biosynthesis of sebum, that is, lipids secreted through the sebaceous glands, can improve acne. First, the gold composition was applied 0.2ml/cm2 to 6-week-old mice with their hair removed, and then massaged for 10 minutes with ultrasonic waves and absorbed into the pores, followed by irradiation with an IPL laser under the condition of a 710nm filter and 30ms. At this time, the mice treated with the gold composition were 20J/cm2, 1 pass, and the mice treated with the gold composition were irradiated with a 10J/cm2, 2pass laser to derive the results of Figure 1.

[Figure 1] Photo of pore destruction tissue

(No treatment of gold composition) (Treatment of gold composition)

In other words, when the gold composition was treated in the pore-destructive tissue photograph, only the pores were selectively destroyed even when irradiated with a low-energy laser. On the other hand, the result showed no effect on the epidermis. Even if the laser was irradiated strongly enough to cause damage, the pores were not completely destroyed.

(6) Acne improvement effect

In the case of applying Formulation Example 1 to the area where acne occurred and then irradiating it with a laser, the result as shown in Figure 2 was derived.

[Figure 2] Acne improvement photo

In other words, in the acne improvement photos, it was confirmed that the acne was quickly improved.

(7) Formulation stability test

Formulation Examples 1, 2, and 3 were prepared and the stability of the formulation was compared and tested. In the stability acceleration experiment, samples were sampled and stored by date while being stored in a dry oven set at a temperature of 55°C, and the stability of the formulation was confirmed by photographing it with an electron microscope. The results are shown in Figures 3 and 4 and Table 5.

[Figure 3] Formulation photos of Formulation Examples 1, 2, and 3

[Figure 4] Electron microscopy pictures for each formulation

(Formulation Example 1) (Formulation Example 2) (Formulation Example 3)

As such, it was confirmed that the stability of the formulation in all of Formulation Examples 1, 2, and 3 of the present invention was not a problem.

As described above, the present invention uses micro gold particles (magnetic metal nanocomposites) to form a cosmetic composition for improving acne, so that micro gold particles are useful for diagnosing and improving cellular diseases, and at the same time, excellent target orientation and improvement for specific cells. As it is effective, it has low toxicity to the human body, has excellent effects such as sebaceous gland destruction and antibacterial action. It is also useful for improving acne without side effects on the skin, and is used for lotions, skins, serums, essences, mask packs, creams, powders, etc. Product stability is excellent, such as being able to be used for hand wash, etc.

The present invention is not limited to the described embodiments, and it is apparent to those of ordinary skill in the art that various modifications and variations can be made without departing from the spirit and scope of the present invention. Therefore, such variations or modifications will have to belong to the scope of the claims of the present invention.

Claims (4)

In the cosmetic composition for improving acne:
It contains gold particles consisting of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nanoparticle layer, and a PEG cover layer as an active ingredient,
The gold particles have a magnetic body having a diameter of 1 nm to 1,000 nm, a dielectric particle layer having a particle diameter of 80 nm to 120 nm, a metal-containing coating layer having a thickness of 10 nm to 30 nm, and a sum of 50 nm to 250 nm. Cosmetic composition containing gold particles for. delete The method of claim 1,
The cosmetic composition is a cosmetic composition containing gold particles for acne improvement, characterized in that it contains 1mg / mL ~ 15mg / mL with respect to the total weight of the cosmetic composition. The method of claim 1,
The cosmetic composition is any one formulation selected from the group consisting of skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, and hand wash. Cosmetic composition comprising gold particles for improving acne, characterized in that produced.