KR20200112151A - Cosmetic compositions containing gold particles for treating acne - Google Patents

Abstract

The present invention relates to a cosmetic composition for treatment of acne comprising: an active ingredient of gold particles consisting of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nanoparticle layer, and a PEG cover layer. In the case, the gold particles of the present invention have magnetic nanoparticles having a diameter of 1 to 1,000 nm, a dielectric particle layer having a particle diameter of 80 to 120 nm, a metal-containing coating layer having a thickness of 10 to 30 nm, and a sum thereof of 50 to 250 nm, and 1 to 15 mg/mL of the cosmetic composition is contained with respect to the total weight of the cosmetic composition. Accordingly, the present invention forms the cosmetic composition for the treatment of acne using micro gold particles (magnetic metal nanocomposites), wherein the micro gold particles are useful for diagnosing and treating cellular diseases while, at the same time, exhibiting excellent target orientation and therapeutic effects for specific cells. Therefore, the present invention has low toxicity to the human body and excellent efficacy such as destruction of sebaceous glands and antibacterial action, and is usefully applied in the treatment of acne without side effects on the skin. The present invention also has excellent product stability, such as being applicable to lotions, toners, serums, essences, sheet masks, creams, powders, hand wash, etc.

Description

Cosmetic compositions containing gold particles for treating acne {Cosmetic compositions containing gold particles for treating acne}

The present invention relates to a cosmetic composition for treating acne, and more specifically, by forming a cosmetic composition for treating acne using micro gold particles (magnetic metal nanocomposite), micro gold particles are used in the diagnosis and treatment of cellular diseases. It is useful and has excellent target orientation and therapeutic effect for specific cells, so it has low toxicity to the human body and has excellent efficacy effects such as sebaceous gland destruction and antibacterial action. It is also useful for acne treatment without side effects on the skin. It relates to a cosmetic composition containing gold particles for acne treatment with excellent product stability, such as being used for serum, essence, mask pack, cream, powder, hand wash, etc.

In recent years, as the life expectancy has increased due to the development of medical technology and the standard of living has been improved due to the rise of national income, interest in health and appearance of modern people is increasing, and a lot of attention has been paid to improving appearance. In modern times, industries related to skin beauty such as wrinkle management, whitening, atopy, and acne management are growing rapidly.

On the other hand, acne occurs mainly during puberty, especially in hormonal changes, and is a pilosebaceous disease characterized by comedones, papules, pustules, and nodules. Recently, the incidence of acne in adults is increasing. In the West, about 79 to 95% of teenage adolescents suffer from acne disease, and especially in the United States, about 40 to 50 million people are known as acne patients. Acne is not limited to adolescents, but also occurs widely in adults, and some studies report that 40% of the male population and 54% of the female population among adults over 25 years of age have acne disease.

To treat such acne, use an applied drug or use a medicine you eat. Antibacterial agents, antibiotics, and exfoliating agents are used as medicines, and antibiotics, corticosteroids, and sebum secretion inhibitors are used as medicines to be eaten. However, in the case of the applied drug, it irritates the skin and develops side effects and resistance when used for a long period of time.

As such, various methods are being studied to treat acne. As a related prior art, Korean Patent Publication No. 1995-0008762 (Prior Document 1), Korean Patent Publication No. 10-0147332 (Prior Document 2), Korea Registered Patent Publication No. 10-0491746 (Prior Document 3) and the like are known.

Prior Literature 1 is Propionibacterium acnes, which is a mixture of plant extracts obtained from myrrh, five baeja, gaja, side white leaves, and ginkgo leaves. Disclosed is a cosmetic composition having an effective effect on acne by inhibiting the growth of ).

Prior Literature 2 is a raw material containing 30-50% by weight (wt%) of gold, silver, yeongyo, gosam, and hyeonsam, 55-65% by weight (wt%) of own plant, and 1-5% by weight (wt%) of Sambaekcho. 1.3-butylene glycol [1.3-buthylene glychol (1.3-BG H2) 10/90 v/v)] was added 4-5 times the volume of the raw material, and heated at 55-70°C for 1.5-2.5 hours 1 After the primary heating, the secondary heating was performed at 100-120℃ for 3-5 hours after the first heating, and then hot water was extracted under reduced pressure and filtered with filter paper to obtain a filtrate, treated with activated carbon, and concentrated under reduced pressure to reduce pressure. A concentrated solution was obtained, and the concentrated solution under reduced pressure was eluted and separated using water or ethanol as a mobile phase by column chromatography in which the weight ratio of Flonisil/zeolite was 3:1, and the water content was 50-60% by volume. Characterized in that a 0.1% volume ratio of each of vitamin biwon (vitamine B1), vitamin B2, vitamin B6, and retinoic acid is mixed with an extract of (V%) Disclosed is an extract composition for acne treatment extracted from natural products.

Prior Document 3 discloses a composition for external application for preventing and treating acne, characterized in that it contains 0.01 to 10% by weight of the extract obtained by filtering and concentrating the extract of Mohwangryeon after extracting it with an aqueous ethanol solution.

However, the above-described prior literature has a problem in that its potency varies depending on plant cultivation conditions, collection time, collection site and extraction method, etc., and it is difficult to stably obtain a large amount compared to treatment with chemical drugs.

In addition, many treatments for acne are external, and antibiotics such as benzoyl peroxide and mycin are used, or exfoliating agents such as salicylic acid are used. Tretinoin is used in cream or gel formulations, and benzoyl peroxide is used for inflammatory acne because it has a strong antibacterial action against acne bacteria. As antibiotics, clindamycin and erythromycin are used. However, these antimicrobial agents and antibiotics may cause side effects on the skin, and if used continuously for a long period of time, resistance may develop or the skin may be strained.

Meanwhile, salicylic acid is the most widely used cosmetic ingredient for acne treatment and is widely used for the purpose of preventing clogging of skin pores and alleviating acne symptoms by speeding up skin regeneration without burdening the skin even after long-term use. Has been. However, salicylic acid alone relieves the symptoms of acne and is insufficient to normalize the skin. Therefore, when used as a general therapeutic drug, antibiotics are added to reduce sterilization and inflammation symptoms. In addition, salicylic acid irritates the skin due to the skin exfoliation effect, and has a low solubility in water, so that an excessive amount of alcohol must be prescribed, which causes the skin to dry out. As medicines to eat, sebum secretion inhibitors such as tetracycline, isotretinoin, adrenal cortical hormone and estrogen are used. Since the medicine you eat works on the whole body, you should be aware of side effects.

Under this background, the present inventors researched to find a cosmetic composition with excellent skin-related efficacy and safety. As a result, micro gold particles, that is, magnetic metal nanocomposites, are useful for diagnosing and treating cellular diseases and at the same time exhibiting excellent target orientation for specific cells. It has been confirmed that when light energy of a specific wavelength is supplied from the outside, it is converted into constant heat energy to generate heat, and the generated heat has effects such as destruction of sebaceous glands and antibacterial action, which are the causes of acne.

Korean Patent Publication No. 1995-0008762 "Cosmetic composition having an effective effect on acne" (announcement date: 1995. 08. 08.) Korean Patent Publication No. 10-0147332 "Extracted composition for improving acne from natural substances" (Registration date: 1998. 05. 16.) Korean Patent Publication No. 10-0491746 "A composition for preventing and treating acne containing Mohwangryeon extract" (Registration date: 2005. 05. 18.)

An object of the present invention for fundamentally improving the conventional problems as described above is to form a cosmetic composition for treating acne using micro gold particles (magnetic metal nanocomposite), so that micro gold particles are used to diagnose and treat cellular diseases. It is useful for treatment of acne without side effects on the skin as well as having low toxicity to the human body and excellent efficacy such as destruction of sebaceous glands and antibacterial action as it exhibits excellent target orientation and therapeutic effect for specific cells. , Serum, essence, mask pack, cream, powder, hand wash, etc. It is intended to provide a cosmetic composition containing gold particles for acne treatment with excellent product stability.

The present invention for achieving the above object is characterized in that it comprises as an active ingredient of gold particles consisting of a magnetic substance, a dielectric particle layer, a metal-containing coating layer, a gold nano particle layer, and a PEG cover layer in a cosmetic composition for treating acne. .

At this time, according to the present invention, the micro gold particles have a magnetic body having a diameter of 1 nm to 1,000 nm, a dielectric particle layer having a particle diameter of 80 nm to 120 nm, a metal-containing coating layer having a thickness of 10 nm to 30 nm, and the sum of 50 nm to 250 nm. It features.

In addition, according to the present invention, the cosmetic composition is characterized in that it contains 1mg/mL to 15mg/mL with respect to the total weight of the cosmetic composition.

In addition, the cosmetic composition of the present invention is selected from the group consisting of skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, hand wash. It is characterized in that it is prepared in any one formulation.

On the other hand, prior to this, terms or words used in the present specification and claims should not be construed as being limited to their usual or dictionary meanings, and the inventors have developed the concept of terms in order to explain their own invention in the best way. It should be interpreted as a meaning and concept consistent with the technical idea of the present invention based on the principle that it can be properly defined. Therefore, the embodiments described in the present specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention, and do not represent all the technical spirit of the present invention, and thus various alternatives that can be substituted for them at the time of application It should be understood that there may be equivalents and variations.

As described in the above configuration and action, the cosmetic composition including gold particles for the treatment of acne according to the present invention uses micro gold particles (magnetic metal nanocomposite) to form a cosmetic composition for treating acne, so that the micro gold particles are It is useful for diagnosing and treating cellular diseases, and at the same time exhibiting excellent target orientation and therapeutic effect for specific cells, so it has low toxicity to the human body and has excellent efficacy effects such as sebaceous gland destruction and antibacterial action. It provides excellent product stability and can be used for lotion, skin, serum, essence, mask pack, cream, powder, hand wash, etc.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

All technical terms used in the present invention, unless otherwise defined, have the following definitions and correspond to the meanings as commonly understood by one of ordinary skill in the relevant fields of the present invention. In addition, although preferred methods or samples are described in the present specification, those similar or equivalent are included in the scope of the present invention.

And the contents of all publications described as references in this specification are introduced into the present invention. The term about refers to 30, 25, 20, 25, 10, 9, 8, 7, 6, 5, 4, for a reference amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length. It means an amount, level, value, number, frequency, percentage, dimension, size, amount, weight, or length, varying by 3, 2 or 1%.

The present invention proposes a cosmetic composition for treating acne. In particular, the target is to apply gold particles consisting of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nanoparticle layer, and a PEG cover layer to a cosmetic composition for treating acne, but is not limited thereto.

Here, in the cosmetic composition for treating acne according to the present invention, it is characterized in that it contains as an active ingredient of gold particles consisting of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nano particle layer, and a PEG cover layer.

On the other hand, the gold particles of the present invention are composed of a magnetic substance, a dielectric particle layer, a metal-containing coating layer, a gold nanoparticle layer, and a PEG cover layer, and the magnetic substance is a magnetic nanoparticle or a magnetic nanocluster that is a group thereof, and is dispersed in the particle or It exists in the form of a core, and the diameter of the magnetic body is formed from 1 nm to 1,000 nm. The dielectric particle layer is selected from the group consisting of silica, titania, polymer particles, alumina, and mixtures thereof while containing the magnetic material, and the dielectric particle layer has a particle diameter of 80 nm to 120 nm.

And the metal-containing coating layer of the present invention is formed on the surface of the dielectric particles and contains a metal selected from the group consisting of Au, Ag, and Pt, and the thickness of the metal-containing coating layer is formed in a range of 10 nm to 30 nm. The gold nanoparticle layer is coated on the surface of the dielectric particle, and the PEG cover layer is coated on the surface of the dielectric particle again.

Meanwhile, the gold particles of the present invention are generally referred to as metal nanocomposites, and are composed of a spherical dielectric core nanoparticle and a thin metal film surrounding the core. The metal nanocomposite can absorb electromagnetic waves by surface plasmon resonance, and the absorbed electromagnetic waves collectively vibrate conductive electrons in the metal film to generate heat. The wavelength range of the electromagnetic wave absorbed by the metal nanocomposite and the corresponding heat generation can be easily controlled by adjusting the type of metal used, the dielectric core nanoparticles, and the thickness of the metal film. In addition, although the degree of electromagnetic waves varies depending on the wavelength, they have a characteristic capable of penetrating living tissues to some extent, and such characteristics of electromagnetic waves are applied as a tool for diagnosing diseases in clinical practice. Based on the properties of such metal nanocomposites and electromagnetic waves, studies for applying metal nanocomposites to drug delivery or disease treatment have been continuously conducted in the art.

These gold particles consist of a total of 50 nm to 250 nm of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nano particle layer, and a PEG cover layer, and these gold particles are 1 mg/mL to 15 mg/mL based on the total weight of the cosmetic composition. To prepare a cosmetic composition containing, more preferably, the gold particles will be preferably contained in 4mg / mL ~ 10mg / mL with respect to the total weight of the cosmetic composition. This is 4 mg/mL for the mild version and approximately 10 mg/mL for the strong version. That is, when the content of the gold particles is less than 4mg/mL, the efficacy is insignificant, and when it exceeds 10mg/mL, there is a problem in safety and stability of the formulation, and it is not economical.

Here, the manufacturing method of the gold particles of the present invention is Korea Patent Publication No. 10-0924786, which is the right of the present invention well known in the art, "diagnosis and treatment magnetic metal nanocomposite" (registration date: 2009. 10. 27. ), but will not be limited thereto.

On the other hand, the cosmetic composition of the present invention is selected from the group consisting of skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, hand wash. It is characterized in that it is prepared in any one formulation. That is, the cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing , Oil, powder foundation, emulsion foundation, wax foundation, spray, etc. may be formulated, but is not limited thereto. That is, in more detail, skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, hand wash.

In addition, cosmetics prepared with the cosmetic composition containing the gold particles as an active ingredient of the present invention can be prepared in the form of a general emulsified formulation and a solubilized formulation. Cosmetics in emulsified form include nutrient lotion, cream, and essence, and cosmetic products in solubilized form include softening lotion.

In addition, by containing a dermatologically acceptable medium or base in addition to the cosmetic containing the active ingredient of the gold particles of the present invention, it can be prepared in the form of an adjuvant that can be applied topically or systemically used in the field of dermatology. . Suitable cosmetic formulations include, for example, solutions, gels, solid or paste dry products, emulsions obtained by dispersing the oil phase in an aqueous phase, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes), nonionic It can be provided in the form of a vesicle dispersant, a cream, skin, lotion, powder, ointment, spray or conceal stick.

In addition, the cosmetic composition of the present invention includes fatty substances, organic solvents, solubilizers, thickeners and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, and interfacial agents in addition to the active ingredients of gold particles. Activators, water, ionic or nonionic emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic activators, lipid vesicles or common in cosmetics It may contain adjuvants commonly used in the field of cosmetology or dermatology, such as any other ingredients used as.

And the above ingredients may be introduced in an amount generally used in the field of dermatology. Products to which the cosmetic composition of the present invention can be added include, for example, astringent lotion, softening lotion, nutrient lotion, various creams, essences, packs, and cosmetics such as foundation, and cleansing, face wash, soap, treatment, beauty liquid Etc. Specific formulations of the cosmetic composition of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, It includes formulations such as soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder, and eye shadow.

Specifically, if the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or Zinc oxide or the like may be used.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol aliphatic ester, polyethyleneglycol or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, liquid diluents such as water, ethanol or propylene glycol as carrier components, ethoxylated isostearyl alcohol, suspending agents such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Sex cellulose, aluminum metahydroxide, bentonite, agar or tracant, and the like can be used.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / May contain propellants such as butane or dimethyl ether. When the formulation of the present invention is a surfactant-containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether Sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative or ethoxylated glycerol fatty acid ester, and the like may be used.

When the cosmetic composition of the present invention is a soap, a cleansing formulation containing a surfactant, or a cleansing formulation containing no surfactant, it may be applied to the skin and then wiped off, removed, or washed with water. As a specific example, the soap is liquid soap, powder soap, solid soap and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel and cleansing pack, and the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotion, cleansing water, and cleansing gel, but is not limited thereto.

On the other hand, the cosmetic method of the present invention refers to all cosmetic methods using the cosmetic composition of the present invention. That is, all methods known in the art using the cosmetic composition belong to the cosmetic method of the present invention. The cosmetic composition of the present invention may be used alone or in duplicate, or may be used in conjunction with other cosmetic compositions other than the present invention. In addition, the cosmetic composition according to the present invention may be used according to a conventional method of use, and the number of times of use thereof may be changed according to a user's skin condition or taste.

Hereinafter, examples and manufacturing examples will be described in detail to aid understanding of the present invention. However, the following Examples and Experimental Examples are for illustrative purposes only, and the scope of the present invention is not limited to the following Examples and Experimental Examples. Examples and preparation examples of the present invention are provided to more completely describe the present invention to those of ordinary skill in the art.

(1) A cosmetic composition for the treatment of acne, that is, a prescription example of a lotion among cosmetic compositions containing the active ingredient of gold particles was prepared as shown in Table 1 below.

(2) A cosmetic composition for the treatment of acne, that is, a formulation example of a cream among the cosmetic compositions containing the active ingredient of gold particles was prepared as shown in Table 2 below.

(3) A cosmetic composition for the treatment of acne, that is, a prescription example of an essence among the cosmetic compositions containing the active ingredient of gold particles was prepared as shown in Table 3 below.

(4) Cytotoxicity evaluation

Using the cosmetic composition for acne treatment prepared in Formulation Examples 1 to 3 according to the present invention, cytotoxicity in HaCaT cells and HDF-Ncells was measured (see Table 4 below). HaCaT cells are well in 96 well plates. At a concentration of 5 x 104 cells per well, HDF-Ncells were dispensed in a 96 well plate at a concentration of 6 x 103 cells per well, and then cultured for 24 hours under cell culture conditions. After removing the medium and washing with DPBS, after maintaining the starvation state for 12 hours, a test solution and a new medium (excluding media supplement) were added and cultured for 24 hours. In addition, after removing the sample solution and medium and washing with PBS, in order to measure the viability of cells, the WST-1 reaction solution was diluted 1/10 in a medium excluding supplement and treated with 100 µl per well for 1 hour reaction. After that, the absorbance was measured at 450 nm. As a result, when the concentration of up to 100 ppm in HaCaT cells and HDF-N cells, Formulation Example 1 shows 99.4% and 98.6% survival rates, Formulation Example 1 shows 99.4% and 98.6% survival rates, and Formulation Example 2 is 99.5 % And 98.4% survival rates, and Formulation Example 3 showed the survival rates of 99.6% and 98.2%, confirming the results shown in Table 4.

As such, it was confirmed that the cosmetic composition for improving the treatment of acne according to the present invention, that is, among the cosmetics included as an active ingredient of gold particles, does not exhibit cytotoxicity, and thus has excellent skin stability.

(5) Effect of destruction of sebaceous glands in pores due to photothermal effect

The occurrence of acne has a combination of causes. In particular, due to the excess of male hormones, the secretion of the sebaceous glands becomes active and the hair follicles are clogged, forming comedones, the basic lesion of acne. Therefore, suppressing the biosynthesis of sebum, that is, lipids secreted through the sebaceous glands, can improve acne. First, the gold composition was applied 0.2ml/cm2 to 6-week-old mice with their hair removed, and then massaged for 10 minutes with ultrasonic waves and absorbed into the pores, followed by irradiation with an IPL laser under the condition of 710nm filter and 30ms. At this time, the mice treated with the gold composition were 20J/cm2, 1 pass, and the mice treated with the gold composition were irradiated with 10J/cm2, 2pass laser to derive the results of Figure 1.

[Figure 1] Photo of pore destruction tissue

(No treatment of gold composition) (Gold composition treatment)

In other words, when the gold composition was treated in the pore-destructive tissue photo, only the pores were selectively destroyed even when irradiated with a low-energy laser. On the other hand, the result showed no effect on the epidermis. Even if the laser was irradiated strongly enough to cause damage, the pores could not be completely destroyed.

(6) Acne treatment effect

In the case of applying Formulation Example 1 to the area where acne occurred and then irradiating it with a laser, the result shown in Figure 2 was derived.

[Figure 2] Acne treatment photo

In other words, in the acne treatment photos, it was confirmed that acne was cured quickly.

(7) Formulation stability test

Formulation examples 1, 2, and 3 were prepared and the stability of the formulation was compared. In the stability acceleration experiment, samples were sampled and stored by date while being stored in a dry oven set at a temperature of 55°C, and the stability of the formulation was confirmed by photographing it with an electron microscope. The results are shown in Figures 3 and 4 and Table 5.

[Figure 3] Formulation photos of Formulation Examples 1, 2, and 3

[Figure 4] Electron microscopic photos by formulation

(Formulation Example 1) (Formulation Example 2) (Formulation Example 3)

As such, it was confirmed that the stability of the formulation in all of Formulation Examples 1, 2, and 3 of the present invention was not a problem.

As described above, the present invention uses micro gold particles (magnetic metal nanocomposites) to form a cosmetic composition for treating acne, so that micro gold particles are useful for diagnosing and treating cellular diseases, and at the same time excellent target orientation and treatment for specific cells. As it is effective, it has low toxicity to the human body and has excellent efficacy effects such as sebaceous gland destruction and antibacterial action. It is also useful for acne treatment without side effects on the skin. Lotion, skin, serum, essence, mask pack, cream, powder, Product stability is excellent, such as being used for hand wash

The present invention is not limited to the disclosed embodiments, and it is obvious to those of ordinary skill in the art that various modifications and variations can be made without departing from the spirit and scope of the present invention. Therefore, such variations or modifications will have to belong to the claims of the present invention.

Claims (4)

In the cosmetic composition for treating acne:
A cosmetic composition comprising gold particles for acne treatment, comprising as an active ingredient of gold particles consisting of a magnetic material, a dielectric particle layer, a metal-containing coating layer, a gold nano particle layer, and a PEG cover layer. The method of claim 1,
The gold particles are acne treatment, characterized in that the diameter of the magnetic body is 1nm ~ 1,000nm, the particle diameter of the dielectric particle layer is 80nm ~ 120nm, the thickness of the metal-containing coating layer is 10nm ~ 30nm, the sum of 50nm ~ 250nm Cosmetic composition containing gold particles for. The method of claim 1,
The cosmetic composition is a cosmetic composition comprising gold particles for acne treatment, characterized in that it contains 1mg / mL ~ 15mg / mL with respect to the total weight of the cosmetic composition. The method of claim 1,
The cosmetic composition is any one formulation selected from the group consisting of skin, lotion, serum, essence, mask pack, UV cream, BB cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, and hand wash. Cosmetic composition comprising gold particles for the treatment of acne, characterized in that produced.