KR20240040154A - Cosmetic Composition for Moisturizing and Soothing Skin Comprising Extracts of Jewelry - Google Patents

Abstract

The present invention relates to a cosmetic composition for promoting skin moisturization and soothing, which contains as active ingredients gold colloid obtained from gold, a type of gem, and malachite extract extracted from malachite. Specifically, the present invention relates to a cosmetic composition using gold colloid and malachite extract mixed in a specific weight ratio, which has superior skin moisturizing and soothing effects compared to using each component individually or in a different weight ratio.

Description

Cosmetic composition for moisturizing and soothing skin containing jewel extract {Cosmetic Composition for Moisturizing and Soothing Skin Comprising Extracts of Jewelry}

The present invention relates to a cosmetic composition for promoting skin moisturization and soothing, which contains gold colloid obtained from gold, a type of gem, and malachite extract extracted from malachite as active ingredients. Specifically, the present invention relates to a cosmetic composition using gold colloid and malachite extract mixed in a specific weight ratio, which has superior skin moisturizing and soothing effects compared to using each component individually or in a different weight ratio.

Dry skin is often accompanied by irritation such as pulling, itching, and even stinging. Various cosmetic compositions have tried to improve dryness of the skin by using various moisturizers such as oils, sugars, and polyols to overcome dryness of the skin. For example, by strengthening the skin barrier function using skin components such as ceramide, cholesterol, and fatty acids, moisture evaporation from the skin can be suppressed, or by using sugars and polyols that have a strong ability to bind moisture on the skin surface, the skin's moisture retention ability can be improved. There are known methods to enhance the skin's moisturizing effect by strengthening it.

Meanwhile, examples of using types of gems include Korea Patent Publication No. 2019-0031634, which discloses a cosmetic composition for wrinkle improvement and anti-aging using gold colloid, and technology for improving the transparency of cosmetics using malachite extract. There is Korean Patent Publication No. 2019-0036341, which discloses a moisturizing-related effect, and Korean Patent No. 1, which discloses a whitening and moisturizing cosmetic composition containing natural mineral extracts such as amethyst extract, pearl extract, and persimmon extract. There is number 10-1719124.

The present inventors conducted research to develop a composition with excellent skin moisturizing and soothing effects. As a result, when gold colloid and malachite extract were mixed in a specific ratio among various substances, each component could be used individually or mixed in different ratios. It was confirmed that it has a very excellent synergistic effect in moisturizing and soothing the skin. The purpose of the present invention is to provide a cosmetic composition that contains gold colloid and malachite extract in a specific weight ratio and exhibits skin moisturizing and soothing effects.

The above task is achieved by a cosmetic composition for promoting skin moisturization and soothing, which contains gold colloid and malachite extract as active ingredients.

Preferably, the gold colloid and the malachite extract may be included in a weight ratio of 1 to 20:80 to 99.

Also preferably, the gold colloid and the malachite extract may be included in an amount of 0.000001 to 1.0% by weight based on the total weight of the cosmetic composition.

Also preferably, the cosmetic composition may have a formulation selected from the group consisting of softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, oil balm, water-soluble gel, detergent, cleansing foam, and makeup cleansing. there is.

The cosmetic composition for promoting skin moisturization and soothing, which contains gold colloid and malachite extract as active ingredients according to the present invention, has excellent skin moisturizing and soothing effects at a specific mixing ratio and content.

All technical terms used in the present invention, unless otherwise defined, have the following definitions and correspond to the meaning as generally understood by a person skilled in the art in the relevant field of the present invention. In addition, preferred methods and samples are described in this specification, but similar or equivalent methods are also included in the scope of the present invention.

The term “about” means 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, 9, 8, 7, 6, 5, or means a quantity, level, value, number, frequency, percentage, dimension, size, volume, weight or length that varies by 4, 3, 2 or 1%.

Throughout this specification, unless the context otherwise requires, the words "comprise" and "comprising" include a given step or component, or group of steps or components, but any other step or component, or It should be understood that this implies that no step or group of components is excluded.

The present invention provides a cosmetic composition for promoting skin moisturization and soothing, comprising gold colloid and malachite extract as active ingredients.

Known effects of gold include not only preventing sagging skin by slowing down collagen consumption and elastin breakdown, but also stimulating cell growth in the basal layer to regenerate healthy, elastic skin, helping with lifting. Additionally, fine particles of pure gold absorb and remove heavy metals and various pollutants that cause skin aging, and are also effective in removing waste products present in pores. In addition, it is known to promote hormone secretion, help activate cells, prevent skin aging, and help prevent wrinkles and remove freckles. Gold's skin purifying effect is said to help relieve various inflammations and acne.

Malachite is derived from the Greek word "Mala'Khe" meaning "the color of mallow" and is an ore created by the weathering of copper deposits and is also called malachite. In ancient Egypt, it was considered a sacred stone. Malachite is made up of hydrated copper carbonate (Cu2(OH)2CO3) as its main ingredient, and contains manganese, silicon, and zinc as other ingredients, and has effects such as detoxifying the body, healing tissues, and facilitating energy flow. , It was used to balance and harmonize body tissues and organs, and was also used for eye or facial treatment and makeup.

Trace elements are chemical elements found in the human body at a concentration of 0.01% or less, and are divided into essential trace elements and non-essential trace elements. In general, if element deficiency causes one or more functional changes and the function is restored through appropriate intake, this trace element can be said to be an essential trace element. Therefore, essential trace elements play a basic physiological (biological) role in the living body. is in charge of 15 essential trace elements: fluoride, iodine, selenium, silicon, chromium, cobalt, iron, lithium, and manganese. ), molybdenum, nickel, copper, tin, vanadium, and zinc. Four elements, copper, manganese, silicon, and zinc, play a major physiological role in the skin. Contribute.

Malachite contains all four elements: copper, manganese, silicon, and zinc, so it can be used as a new mineral source for stressed skin. In particular, copper, the main ingredient, promotes keratin synthesis in keratinocytes, has antioxidant effects, increases collagen and elastin synthesis by activating lysyl oxidase, and protects the skin from light by synthesizing melanin precursors. It is also known to play a role.

The present invention provides a cosmetic composition that exhibits a synergistic effect by comprising gold colloid and malachite extract in a specific weight ratio.

According to one embodiment of the present invention, the cosmetic composition is characterized in that it contains gold colloid and malachite extract mixed in a weight ratio of 1 to 20:80 to 99. More preferably, gold colloid and malachite extract are mixed at a weight ratio of 3:97.

The gold colloid and malachite extract are preferably included in an amount of 0.000001 to 1.0% by weight based on the total weight of the cosmetic composition. If it is less than 0.000001% by weight, the effect of soothing the skin and relieving irritation is minimal, and if it exceeds 1.0% by weight, the effect of moisturizing and soothing the skin is minimal as the content increases. More preferably, it is contained in 0.001 to 0.5% by weight. In particular, when it exceeded 0.5% by weight, it was confirmed that the effect did not increase significantly compared to the content, resulting in reduced economic efficiency.

In order to select a specific mixing ratio, the effect of suppressing IL-α secretion in keratinocytes was evaluated according to the mixing ratio of gold colloid and malachite extract, and the skin irritation relief effect and moisturizing effect were verified through actual use tests by applying each composition to the formulation. Confirmed. In addition, in order to select the optimal content, it was evaluated through actual use tests within the range of 0.000001 to 1.0% by weight in the formulation.

The ingredients included in the cosmetic composition of the present invention are active ingredients and may include ingredients commonly used in cosmetic compositions in addition to the above-mentioned active ingredients, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances. Includes adjuvants and carriers.

The cosmetic composition of the present invention can be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing products. , oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream and spray, etc., but is not limited thereto. More specifically, it can be manufactured in the form of softening lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, oil balm, water-soluble gel, cleansing foam, or makeup cleansing.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier ingredient. You can.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent, or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, the carrier ingredients include water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, and microcrystals. Cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder can be used as the carrier ingredient. In particular, when the formulation is a spray, chlorofluorohydrocarbon and propane may be used as carrier ingredients. /May contain propellants such as butane or dimethyl ether.

In the case of a cleansing formulation containing a surfactant, the carrier ingredients include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, and fatty acid. Amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester can be used.

When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it can be applied to the skin and then wiped off, removed, or washed with water. As a specific example, the soap is liquid soap, powdered soap, solid soap, and oil soap, the surfactant-containing cleansing formulation is cleansing foam, cleansing water, cleansing towel, and cleansing pack, and the surfactant-free cleansing formulation is cleansing cream. , cleansing lotion, cleansing water, and cleansing gel, but are not limited thereto.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Example 1: Preparation of samples by composition of gold colloid and malachite extract

(1) Manufacturing gold colloid

Add 10 ml of 0.1M chloroauric acid (HAuCl ₄ ) aqueous solution and stir while simultaneously heating to 100°C to create a mixed solution, then mix 1g of aqueous solution containing 5mM sodium citrate until the mixed solution turns purple. After stirring, the gold colloid with a size of 100 nm or less was filtered, dried, and granulated to be used as an active gold colloid.

(2) Malachite extract production

The malachite extract is obtained by pulverizing malachite ore, extracting and stabilizing it for 8 hours with an extraction solvent using ethanol in an amount 10 times the weight of the crushed malachite ore, and then filtering to 50 μm or less to obtain a blue liquid substance. .

(3) Gold colloid: Preparation of samples according to malachite extract composition

Samples were prepared by mixing gold colloid and malachite extract in weight ratio as follows.

Sample name colloidal gold malachite
extract Manufacturing Example 1 100 0 Production example 2 80 20 Production example 3 60 40 Production example 4 40 60 Production example 5 20 80 Production example 6 15 85 Production example 7 10 90 Production example 8 5 95 Production example 9 3 97 Production example 10 One 99 Production example 11 0 100

Experimental Example 1: Evaluation of the inhibitory effect of IL-1α secretion in HaCaT keratinocytes for mixed samples of gold colloid and malachite extract

In a 24-well plate, HaCaT keratinocytes (German Cancer Research Institute, Germany) were inoculated at a density of ² Cultivated for 1 day in a 5% CO ₂ incubator at ℃. After being exchanged for serum-free DMEM, all samples of Preparation Examples 1 to 11 were treated with 100ppm, cultured for 1 day, treated with SDS (sodium dodecyl sulfate, Sigma), and cultured for an additional 4 hours. After 4 hours, a portion of the culture medium was taken and used for IL-1α and protein quantification. IL-1α quantification was performed using Endogen's human IL-1α kit according to the kit's IL-1α quantification method. Protein was quantified using Sigma's BCA method, and IL-1α quantified with the kit was corrected to the protein amount to determine the unit. The amount of IL-1α secretion per protein was measured. Ketopropen, which was previously used as a skin irritation relief substance, was used as a positive control, and the final IL-1α production rate (%) was calculated using Equation 1 below.

Sample name IL-1α production rate (%) SDS only processing 100±0.13 Manufacturing Example 1 96±0.15 Production example 2 94±0.14 Production example 3 94±0.13 Production example 4 93±0.12 Production example 5 60±0.13 Production example 6 58±0.11 Production example 7 56±0.12 Production example 8 54±0.16 Production example 9 44±0.15 Production example 10 55±0.14 Production Example 11 98±0.13 Ketopropen 42±0.13

Looking at Table 2 above, it was found that in the samples of Preparation Examples 5 to 10, especially in Preparation Example 9, the amount of IL-1α secretion from keratinocytes after SDS treatment decreased significantly compared to other samples. In this experiment, we looked at the biosynthesis of IL-1α, which can cause erythema on the skin through SDS treatment. When the amount of IL-1α when skin cells were treated with SDS alone was set to 100, the After calculating the amount of IL-1α produced, this was converted into percentage. In other words, these results show that gold colloid: malachite extract = 1 ~ 20: 80 ~ 99 (weight ratio) reduces the amount of IL-1α produced in the sample, thereby having a significant effect in relieving skin problems such as erythema. can do.

Example 2: Application test for each composition of gold colloid and malachite extract in formulation

Tables 3 and 4 below show the application of formulations for each composition of gold colloid and malachite extract to sample preparation examples 1 to 11 prepared in Example 1. The formulation example was prepared according to a common method in the cosmetics industry for producing creams. The unit is weight%.

award ingredient Formulation Example 1 Formulation Example 2 Formulation Example 3 Formulation Example 4 Formulation Example 5 A Purified water To 100 To 100 To 100 To 100 To 100 AHA 3.0000 3.0000 3.0000 3.0000 3.0000 Butylene glycol 6.0000 6.0000 6.0000 6.0000 6.0000 glycerin 4.0000 4.0000 4.0000 4.0000 4.0000 Niacinamide 2.0000 2.0000 2.0000 2.0000 2.0000 Trehalose 1.0000 1.0000 1.0000 1.0000 1.0000 1,2-hexanediol 0.5000 0.5000 0.5000 0.5000 0.5000 xanthan gum 0.2000 0.2000 0.2000 0.2000 0.2000 Adenosine 0.0400 0.0400 0.0400 0.0400 0.0400 Disodium EDTA 0.0200 0.0200 0.0200 0.0200 0.0200 B shea butter 4.0000 4.0000 4.0000 4.0000 4.0000 Cetyl Ethyl Hexanoate 3.0000 3.0000 3.0000 3.0000 3.0000 sunflower seed oil 3.0000 3.0000 3.0000 3.0000 3.0000 dimethicone 2.0000 2.0000 2.0000 2.0000 2.0000 Glyceryl Stearate 1.5000 1.5000 1.5000 1.5000 1.5000 Cetearyl alcohol 1.5000 1.5000 1.5000 1.5000 1.5000 Arachidyl alcohol 1.1000 1.1000 1.1000 1.1000 1.1000 ceresin 1.0000 1.0000 1.0000 1.0000 1.0000 Pentaerythrityl tetraethylhexanoate 1.0000 1.0000 1.0000 1.0000 1.0000 Hydrogenated vegetable oil 1.0000 1.0000 1.0000 1.0000 1.0000 Behenyl alcohol 0.6000 0.6000 0.6000 0.6000 0.6000 PEG-100 Stearate 0.5000 0.5000 0.5000 0.5000 0.5000 Arachidyl Glucoside 0.3000 0.3000 0.3000 0.3000 0.3000 C Purified water 4.9000 4.9000 4.9000 4.9000 4.9000 carbomer 0.1000 0.1000 0.1000 0.1000 0.1000 D Purified water 0.3600 0.3600 0.3600 0.3600 0.3600 Potassium Hydroxide 0.0400 0.0400 0.0400 0.0400 0.0400 E Polyacrylate-13 0.3720 0.3720 0.3720 0.3720 0.3720 polyisobutene 0.1920 0.1920 0.1920 0.1920 0.1920 Polysorbate 20 0.0360 0.0360 0.0360 0.0360 0.0360 F Phenoxyethanol 0.3600 0.3600 0.3600 0.3600 0.3600 Ethylhexylglycerin 0.0400 0.0400 0.0400 0.0400 0.0400 G Spices 0.0700 0.0700 0.0700 0.0700 0.0700 H Manufacturing example 1 0.0100 - - - - Production example 2 - 0.0100 - - - Production example 3 - - 0.0100 - - Production example 4 - - - 0.0100 - Production example 5 - - - - 0.0100

award ingredient Formulation Example 6 Formulation Example 7 Formulation Example 8 Formulation Example 9 Formulation Example 10 Formulation Example 11 A Purified water To 100 To 100 To 100 To 100 To 100 To 100 AHA 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 Butylene glycol 6.0000 6.0000 6.0000 6.0000 6.0000 6.0000 glycerin 4.0000 4.0000 4.0000 4.0000 4.0000 4.0000 Niacinamide 2.0000 2.0000 2.0000 2.0000 2.0000 2.0000 Trehalose 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1,2-hexanediol 0.5000 0.5000 0.5000 0.5000 0.5000 0.5000 xanthan gum 0.2000 0.2000 0.2000 0.2000 0.2000 0.2000 Adenosine 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 Disodium EDTA 0.0200 0.0200 0.0200 0.0200 0.0200 0.0200 B shea butter 4.0000 4.0000 4.0000 4.0000 4.0000 4.0000 Cetyl Ethyl Hexanoate 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 sunflower seed oil 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 dimethicone 2.0000 2.0000 2.0000 2.0000 2.0000 2.0000 Glyceryl Stearate 1.5000 1.5000 1.5000 1.5000 1.5000 1.5000 Cetearyl alcohol 1.5000 1.5000 1.5000 1.5000 1.5000 1.5000 Arachidyl alcohol 1.1000 1.1000 1.1000 1.1000 1.1000 1.1000 ceresin 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 Pentaerythrityl tetraethylhexanoate 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 Hydrogenated vegetable oil 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 Behenyl alcohol 0.6000 0.6000 0.6000 0.6000 0.6000 0.6000 PEG-100 Stearate 0.5000 0.5000 0.5000 0.5000 0.5000 0.5000 Arachidyl Glucoside 0.3000 0.3000 0.3000 0.3000 0.3000 0.3000 C Purified water 4.9000 4.9000 4.9000 4.9000 4.9000 4.9000 carbomer 0.1000 0.1000 0.1000 0.1000 0.1000 0.1000 D Purified water 0.3600 0.3600 0.3600 0.3600 0.3600 0.3600 Potassium Hydroxide 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 E Polyacrylate-13 0.3720 0.3720 0.3720 0.3720 0.3720 0.3720 polyisobutene 0.1920 0.1920 0.1920 0.1920 0.1920 0.1920 Polysorbate 20 0.0360 0.0360 0.0360 0.0360 0.0360 0.0360 F Phenoxyethanol 0.3600 0.3600 0.3600 0.3600 0.3600 0.3600 Ethylhexylglycerin 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 G Spices 0.0700 0.0700 0.0700 0.0700 0.0700 0.0700 H Production example 6 0.0100 - - - - - Production example 7 - 0.0100 - - - - Production example 8 - - 0.0100 - - - Production example 9 - - - 0.0100 - - Production example 10 - - - - 0.0100 - Production example 11 - - - - - 0.0100

The manufacturing method is as follows. Warm A and B phases to 75°C and mix with a homogenizer at 3000 rpm for 5 minutes. After cooling to 65°C, add phase C and mix with a homogenizer at 3000 rpm for 3 minutes, then add phase D and mix with a homogenizer at 3000 rpm for 3 minutes. After adding phase E, mix with a homogenizer at 3000 rpm. After cooling to 45°C, phase F, G, and finally phase H, which is a production example sample, are added according to the content of each sample and mixed at 2800 rpm for 3 minutes. Formulation examples 1 to 11 were all manufactured in the same manner.

Experimental Example 2: Skin irritation relief effect of cosmetic composition according to the composition of gold colloid and malachite extract

The irritation-relieving effect of Formulation Examples 1 to 11 for Example 2 was evaluated through actual use tests. In other words, 220 women were divided into 11 parts and used on both sides of their face for 2 weeks to evaluate whether or not there was irritation on their skin.

sample Irritation relieving effect Effective rate (%) No irritation Mild irritation strong stimulation Formulation Example 1 0 14 6 0 Formulation Example 2 One 15 4 5 Formulation Example 3 One 17 2 5 Formulation Example 4 One 18 One 5 Formulation Example 5 10 10 0 50 Formulation Example 6 12 8 0 60 Formulation Example 7 13 7 0 65 Formulation Example 8 14 6 0 70 Formulation Example 9 16 4 0 80 Formulation Example 10 14 6 0 70 Formulation Example 11 0 14 6 0

Looking at Table 5, it was confirmed that formulation examples 5 to 10 all showed a higher irritation alleviation effect than other formulation examples, and among these, formulation example 9 showed the highest irritation alleviation effect.

Experimental Example 3: Measurement of moisturizing power according to the composition of gold colloid and malachite extract

The clinical moisturizing effect of Formulation Examples 1 to 11 for Example 2 was measured as follows. Through a survey, 220 healthy adult men and women who felt that their skin was dry were randomly divided into 11 groups of 20 each, and the cream formulations of Formulation Examples 1 to 11 were applied to the face twice a day for 8 weeks. The moisturizing effect was evaluated every two weeks from the start of the actual use test, and the improvement effect after the end was evaluated using a skin moisture meter (Corneometer CM 820) (Corage+Khazaka, Germany). The experimental results are shown in Table 6 below.

Sample name Before use 2 weeks after use After 4 weeks of use After 8 weeks of use Formulation Example 1 49 51 54 56 Formulation Example 2 48 51 53 55 Formulation Example 3 49 52 54 57 Formulation Example 4 48 51 54 55 Formulation Example 5 47 58 63 66 Formulation Example 6 48 60 65 67 Formulation Example 7 47 60 65 68 Formulation Example 8 49 63 68 70 Formulation Example 9 48 65 75 79 Formulation Example 10 47 61 66 70 Formulation Example 11 49 52 54 57

In Table 6, the unit of skin moisturizing effect is an arbitrary unit measured by a skin moisture meter.

As shown in Table 6, as a result of measuring the moisturizing effect of the cosmetics prepared according to Formulation Examples 1 to 11, Formulation Examples 5 to 10 had better moisturizing effects than formulations with other compositions, and among them, Formulation Example 9 was confirmed to be the best.

Accordingly, it was confirmed that the composition ratio of gold colloid and malachite extract of 1 ~ 20: 80 ~ 99 (% by weight) was very superior to other composition ratios, of which Formulation Example 9 where the composition ratio of gold colloid and malachite extract was 3: 97 (% by weight) was selected and an application experiment for each content was conducted.

Example 3: Preparation Example 9 application test by concentration in formulation

Table 7 below shows the application of the formulation according to concentration for Sample Preparation Example 9, in which the composition ratio of the gold colloid and malachite extract prepared in Example 1 was 3:97 (% by weight). The formulation example was prepared according to a common method in the cosmetics industry for producing creams. The unit is weight%.

award ingredient Formulation Example 12 Formulation Example 13 Formulation Example 14 Formulation Example 9 Formulation Example 15 Formulation Example 16 Formulation Example 17 A Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 AHA 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 Butylene glycol 6.0000 6.0000 6.0000 6.0000 6.0000 6.0000 6.0000 glycerin 4.0000 4.0000 4.0000 4.0000 4.0000 4.0000 4.0000 Niacinamide 2.0000 2.0000 2.0000 2.0000 2.0000 2.0000 2.0000 Trehalose 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1,2-hexanediol 0.5000 0.5000 0.5000 0.5000 0.5000 0.5000 0.5000 xanthan gum 0.2000 0.2000 0.2000 0.2000 0.2000 0.2000 0.2000 Adenosine 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 Disodium EDTA 0.0200 0.0200 0.0200 0.0200 0.0200 0.0200 0.0200 B shea butter 4.0000 4.0000 4.0000 4.0000 4.0000 4.0000 4.0000 Cetyl Ethyl Hexanoate 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 sunflower seed oil 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 3.0000 dimethicone 2.0000 2.0000 2.0000 2.0000 2.0000 2.0000 2.0000 Glyceryl Stearate 1.5000 1.5000 1.5000 1.5000 1.5000 1.5000 1.5000 Cetearyl alcohol 1.5000 1.5000 1.5000 1.5000 1.5000 1.5000 1.5000 Arachidyl alcohol 1.1000 1.1000 1.1000 1.1000 1.1000 1.1000 1.1000 ceresin 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 Pentaerythrityl tetraethylhexanoate 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 Hydrogenated vegetable oil 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 Behenyl alcohol 0.6000 0.6000 0.6000 0.6000 0.6000 0.6000 0.6000 PEG-100 Stearate 0.5000 0.5000 0.5000 0.5000 0.5000 0.5000 0.5000 Arachidyl Glucoside 0.3000 0.3000 0.3000 0.3000 0.3000 0.3000 0.3000 C Purified water 4.9000 4.9000 4.9000 4.9000 4.9000 4.9000 4.9000 carbomer 0.1000 0.1000 0.1000 0.1000 0.1000 0.1000 0.1000 D Purified water 0.3600 0.3600 0.3600 0.3600 0.3600 0.3600 0.3600 Potassium Hydroxide 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 E Polyacrylate-13 0.3720 0.3720 0.3720 0.3720 0.3720 0.3720 0.3720 polyisobutene 0.1920 0.1920 0.1920 0.1920 0.1920 0.1920 0.1920 Polysorbate 20 0.0360 0.0360 0.0360 0.0360 0.0360 0.0360 0.0360 F Phenoxyethanol 0.3600 0.3600 0.3600 0.3600 0.3600 0.3600 0.3600 Ethylhexylglycerin 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 0.0400 G Spices 0.0700 0.0700 0.0700 0.0700 0.0700 0.0700 0.0700 H Production example 9 0.0000 0.000001 0.0001 0.0100 0.1000 0.5000 1.0000

The manufacturing method is the same as Example 2, and the manufacturing method is as follows.

Warm A and B phases to 75°C and mix with a homogenizer at 3000 rpm for 5 minutes. After cooling to 65°C, phase C was added and mixed with a homogenizer at 3000 rpm for 3 minutes, then phase D was added and mixed with a homogenizer at 3000 rpm for 3 minutes. After adding phase E, mix with a homogenizer at 3000 rpm. After cooling to 45°C, Preparation Example 9, which is the F, G phase, and finally H phase, is added in each content and mixed at 2800 rpm for 3 minutes. Formulation Example 9 and Formulation Examples 12 to 17 were all manufactured using the same method.

Experimental Example 4: Effect of relieving skin irritation of cosmetic composition according to concentration of Preparation Example 9

The irritation-relieving effect of Formulation Example 9 and Formulation Examples 12 to 17 relative to Example 3 was evaluated through actual use tests. In other words, 140 women were divided into 7 parts and used on both sides of their face for 2 weeks to evaluate whether or not there was any irritation on their skin.

sample Irritation relieving effect Effective rate (%) No irritation Mild irritation strong stimulation Formulation Example 12 0 6 14 0 Formulation Example 13 10 5 5 50 Formulation Example 14 12 4 4 60 Formulation Example 9 16 4 0 80 Formulation Example 15 17 3 0 85 Formulation Example 16 18 2 0 90 Formulation Example 17 18 2 0 90

Looking at Table 8 above, in the case of Formulation Example 12, it was confirmed that there was no sedative effect in the control group and that the irritation relieving effect increased depending on the concentration of Preparation Example 9, and in the case of Formulation Example 17, the irritation relieving effect compared to Formulation Example 16 was confirmed. It was confirmed that there was no increase.

Accordingly, it was confirmed that the concentration of Preparation Example 9 was effective for the sedative effect at a concentration of 0.000001% by weight or more.

On the other hand, in the case of Formulation Examples 16 and 17, where the usage concentration of Preparation Example 9 is 0.5% by weight and 1.0% by weight, respectively, the effectiveness rate is the same, so it is judged that economic feasibility is low when the usage concentration is 0.5% by weight or more.

Experimental Example 5: Measurement of moisturizing power of cosmetic composition according to concentration of Preparation Example 9

The clinical moisturizing effect of Formulation Example 9 and Formulation Examples 12 to 17 relative to Example 3 was measured as follows. Through a survey, 140 healthy adult men and women who felt that their skin was dry were randomly divided into 7 groups of 20 people each, and the cream formulations of Formulation Example 9 and Formulation Examples 12 to 17 were applied to the face twice a day for 8 weeks. did. The moisturizing effect was evaluated every two weeks from the start of the actual use test, and the improvement effect after the end was evaluated using a skin moisture meter (Corneometer CM 820) (Corage+Khazaka, Germany). The experimental results are shown in Table 9 below.

Sample name Before use 2 weeks after use After 4 weeks of use After 8 weeks of use Formulation Example 12 49 51 54 56 Formulation Example 13 48 62 67 69 Formulation Example 14 46 62 69 71 Formulation Example 9 48 65 75 79 Formulation Example 15 47 66 76 79 Formulation Example 16 48 68 78 81 Formulation Example 17 47 67 77 80

The unit of skin moisturizing effect in the table above is an arbitrary unit measured by a skin moisture meter.

As shown in Table 9, as a result of measuring the moisturizing effect of the cosmetics prepared according to Formulation Example 9 and Formulation Examples 12 to 17, the moisturizing effect was very low in the case of Formulation Example 12, while the concentration of Preparation Example 9 increased. Accordingly, it was confirmed that the moisturizing power increased, and in the case of Formulation Example 9 and Formulation Examples 14 to 17, it can be seen that the moisturizing enhancing effect was very excellent.

Accordingly, it was confirmed that the concentration of Formulation Example 9 was effective for the sedative effect at a concentration of 0.000001% by weight or more.

On the other hand, in the case of Formulation Examples 16 and 17, where the usage concentrations of Preparation Example 9 were 0.5% by weight and 1.0% by weight, respectively, the difference between the results 4 to 8 weeks after use and the results before use was 30 and 33, respectively. Therefore, it is judged that the economic feasibility is low when the concentration used is 0.5% by weight or more.

As the specific parts of the present invention have been described in detail above, it is clear to those skilled in the art that these specific techniques are merely preferred embodiments and do not limit the scope of the present invention. Accordingly, the actual scope of the present invention will be defined by the appended claims.

Claims (4)

A cosmetic composition for promoting skin moisturization and soothing, containing gold colloid and malachite extract as active ingredients. The cosmetic composition according to claim 1, wherein the gold colloid and the malachite extract are contained in a weight ratio of 1 to 20:80 to 99. The cosmetic composition for promoting skin moisturization and soothing according to claim 1, wherein the gold colloid and the malachite extract are contained in an amount of 0.000001 to 1.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the cosmetic composition has a formulation selected from the group consisting of softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, oil balm, water-soluble gel, detergent, cleansing foam, and makeup cleansing. A cosmetic composition for promoting skin moisturization and soothing.