KR20150010691A - Hair loss preventing, skin and scalp protecting herbal cosmetic composition containing extracts of saxifrage, coptis, houttuynia, ginseng, peony root, paeonia suffruticosa, yeast and pleuropterus multiflorus, and its manufacturing method - Google Patents

Abstract

The present invention relates to a herbal cosmetic composition for protecting skin and scalp containing extracts of Horseshoe chinensis, Rhodophyta, Persimmon, Ginseng, Peony, Peony, Yeast Extract, Ginseng, peonies, peanuts, yeast extracts, and sewage are mixed with ethanol, and then the ethanol extract is heated to cool the resulting vapor to remove the solvent and to obtain a concentrate. , Peanut, yeast extract, and sucrose, and then heating each of the ethanol extracts to cool the resulting vapor to remove the solvent. Each concentrate is then mixed to obtain various vitamins And a vitamin precursor to further enhance the hair growth function of the composition. The herbal cosmetic composition according to the present invention inhibits the 5-reducing enzyme in the body to prevent the formation of DHT in the metabolic process of male hormone and to help the metabolism of hair by cell regeneration in the function of the epithelial tissue of the human body Is a hair growth composition that can be used for the treatment of male alopecia, and is effective in preventing hair loss and is suitable for addition of cosmetics for protecting skin and scalp.

Description

TECHNICAL FIELD The present invention relates to a herbal cosmetic composition for protecting skin and scalp and for preventing hair loss, and a method for manufacturing the same, and a method for manufacturing the same. TECHNICAL FIELD The present invention relates to a herbal cosmetic composition for preventing hair loss, , COPTIS, HOUTTUYNIA, GINSENG, PEONY ROOT, PAEONIA SUFFRUTICOSA, YEAST AND PLEUROPTERUS MULTIFLORUS, AND ITS MANUFACTURING METHOD}

The present invention relates to a herbal cosmetic composition for protecting skin and scalp containing herbal extracts such as Ganoderma lucidum, Rhodiola, Ganoderma lucidum, Ginseng, Peony root, Peony, Yeast extract,

Recently, the number of people suffering psychological distress due to hair loss has been increasing, and interest in hair loss prevention and wool has also increased in young and middle-aged men and women. However, despite the increased interest and demand for hair loss treatment, the precise cause and mechanisms of hair loss have not been clarified precisely, and it is urgent to develop an agent for treating or preventing hair loss.

Human hair consists of a protein called 'keratin', which is a protein that makes up nails and claws. Our visible hair is composed of three layers of tissue formed in a 'follicle' shaped like a bag about 4 mm below the skin. The top layer is a thin, hard, scaly protective layer that is not colored. The middle layer is the thickest, hair-supporting structure, which determines whether hair is curled or curled, and the color of the hair. The first inner layer is a layer composed of living cells that nourishes hair growth.

There is a nipple in the hair follicle, where small blood vessels are distributed to supply the nutrients needed for hair growth, and beside the papilla there is a bore fountain that supplies the oil that gives the hair shine. The growth of these hair follicles is under the influence of 'testosterone', the hair on the armpits and genitals is particularly sensitive to this hormone, so it first appears and grows at puberty rather than the hair of other parts of the body. On the other hand, the hair of the head is affected by dihydrotestosterone (DHT), a derivative of male hormone.

The hair follicles are originally formed in the prenatal period, and no new hair follicles are formed after birth. Even when grown up, the number remains the same but decreases in old age. The hair that first appears in the fetal period is called the lanugo hair, which falls off in about 8 months in the maternal uterus. After birth, it is vellus hair, thin, pale, colorless and within 2cm in size. These wounds can also be seen in the front hair when male pattern hair loss progresses. Through puberty, the female hair turns into a terminal hair and turns into a thick, strong, colored hair.

This growth of the female mothers is affected by male hormones, and in the case of male alopecia, the effect of DHT changes into a woman's hair and eventually hair loss occurs. On average, there are 100,000 Virgin Marys on the head, and they repeatedly produce and disappear with a periodic change of growth, regressor, and pause.

In addition, hair is affected by various factors such as age, season, race, physiological factors, stress, and disease, and usually has about 50 ~ 100 normal 'degenerative hair loss' in a day. Usually, the hair grows up to about 2 ~ 6 years. During this period, the hair grows continuously and its growth rate is about 4 ~ 6㎜ per month. The growth rate is the fastest when it is hot and the slowest when it is cold. And hair loss occurs more in spring, autumn and winter than summer. Hair growth is usually the most active between 15 and 30 years old, gradually progressing to 40 and 50 years old. If you are over 50 years old, natural hair loss due to aging begins to occur and hair loss is accelerated after age 70.

The types, cause and treatment of hair loss are as follows.

It is usually subjective and ideological to look for cases of normal hair loss symptoms. Of course, there are obvious hair loss symptoms and lesions, but there are no obvious lesions, objectively count hair loss hair number, do not observe the shape of hair, and often complain symptoms. In other words, "the number of hair is reduced" when the hair is tapered or smaller, or break easily broken, sometimes even talk about the phenomenon, there is no change in the number of hairs in many cases. Therefore, when you have alopecia ages, it is important to accurately assess your current hair condition and to understand your physical and mental health status as a whole.

Such hair loss symptoms are classified into alopecia areata, resting alopecia, growing alopecia, scalp disease and alopecia areata as follows.

Alopecia areata usually occurs on the scalp suddenly with one to two hairy loosening. In addition to scalp, beard, eyebrows and conspiracy can also be seen, and in severe cases hair loss can occur in the whole body. Although the exact cause is not known yet, it is thought that it is caused by autoimmune mechanism and genetic and psychological (especially stress) postpartum affects it. It may be cured naturally, but it is better to treat if the symptoms last longer than 3 months or progress more. The most common treatment modality is injection of corticosteroids and induction of immune response.

In the case of resting alopecia, hair loss of about 50 ~ 100 dormant hairs per day occurs in a normal adult, which is the case when hair loss occurs more than the normal hair loss, and if the investigation is done well, the cause can be found out. The causes are as follows.

The first is to take drugs, anticoagulants, antidepressants, antihypertensive drugs, anti-ulcer drugs, anti-arthritis drugs, anticonvulsants, vitamin A induction system (acne treatment) and contraceptive. If you have problems with hair loss during use of these medicines, use other medicines with the same effect. Second, excessive diet, excessive protein due to lack of diet or anemia due to iron deficiency may lead to hair loss. The third is stress or fever, severe infectious disease, chronic disease, major surgery, etc. In these cases, hair loss may occur within about 3 months of the cause. Fourth, hyperthyroidism or hypothyroidism may cause hair loss in these cases.

In most cases, the growth of hair is restored after about 6 months if the stimulus is removed.

Alopecia in growing stage is a condition in which hair follicles are acutely severely damaged and 80 ~ 90% of hair is rapidly disappeared. Many cases are caused by chemotherapeutic agents and X-ray irradiation used in the treatment of malignant tumors. In this case, if the administration of the causative agent is stopped, the hair follicle is recovered within a few weeks, so that the hair follicle is regenerated, but the regenerated hair is thin and the growth is deteriorated.

Scalp disease can cause partial hair loss in patients with seborrheic dermatitis, fungal diseases, scleroderma, lupus, mosquito, tumor, syphilis (stage 3). Among the above diseases, seborrheic dermatitis is the most common and shows a similar pattern of hair loss as degenerative alopecia.

Seborrhoeic dysplasia often appears as alopecia of the male in many cases. This phenomenon is due to the effect of DHT on the bloom.

In many cases, alopecia of male pattern starts from the forehead side and goes up to "M-" shape, and the hair loss on the ovary area progresses, so that the "hairless hair" disappears and only the "hairiness" remains. At the same time, it is a common phenomenon that the hair experiences thin, small, and loss of strength with hair loss. Male hair loss is affected by three factors: age, genetic factors, and DHT.

The mechanism by which these factors cause male pattern hair loss is as follows.

The testosterone in the body is converted to DHT form by the 5-reductase enzyme in the metabolic process. This DHT acts on the hair follicle with the male genital hair loss factor, and the hair follicle becomes more and more shrunken and eventually disappears or becomes a small fluffy It will result in remaining. Therefore, DHT is not formed in the metabolic process of the male hormone if the 5-reducing enzyme is inhibited, but the male hormone is maintained normally, so that the male sex is maintained but the hair loss is prevented.

Using this principle, a rationale for prevention of male alopecia can be established.

Propecia is a drug that has been launched from the US pharmaceutical company Merck in the above rationale. This drug has been reported to have a hair loss effect in about 86% of the study group and about 66% of the taking group, but the disadvantage is a) it should be taken continuously, b) relatively expensive, c) Loss of libido, and side effects such as erectile dysfunction are reported.

Another FDA-approved antioxidant is minoxidil, which is a young, oily, and somewhat effective (20 to 30%), In other cases, the effect is not very good.

Women's alopecia are much more common than people usually think, and experience about two-thirds of women once in a lifetime. There are various types of female hair loss such as female hair loss, hair loss due to pregnancy, and the like. Gynecologic alopecia is similar to male alopecia, and as it gets older, progressive alopecia occurs. Unlike men, hair loss generally occurs without any form. Generally from 25 years old to 30 years old, hair gradually thinning and shortening, you will notice the feeling of thinning of the giraffe area. Fifty percent of hair loss in adult women is unhealthy or unhealthy, and hair loss is permanent and genetic.

Hair loss due to pregnancy can occur during pregnancy or about 6 months after conception, and in many cases it is almost recoverable but permanent hair loss may occur.

In normal women, hair loss of about 50 ~ 100 per day occurs in normal women. When hair loss is more than normal hair loss, finding the cause causes many cases to be known. Here is the case.

The first is to take drugs, anticoagulants, antidepressants, antihypertensive drugs, anti-ulcer drugs, anti-arthritis drugs, anticonvulsants, vitamin A induction system (acne treatment) and contraceptive. If hair loss problems arise during use of these medicines, hair loss due to medication may be promoted. Secondly, excessive diet can lead to hair loss if there is anemia due to lack of protein or iron deficiency. The third is a case of stress or fever, severe infectious disease, chronic disease, or major surgery, and hair loss may occur within about 3 months of the cause. Fourth, hyperthyroidism or hypothyroidism may cause hair loss. In most cases, the growth of hair is restored after about 6 months if the stimulus is removed.

Vitamins, along with minerals, are essential substances that are involved in the regulation of the metabolism of the human body in small amounts. Depending on its solubility, it is divided into fat-soluble and water-soluble vitamins. It participates in metabolism in the body and exhibits a unique reaction. Vitamins can not be synthesized in the body.

Vitamin B1 helps the growth of cells, and by proper diffusion of this vitamin B1, cells grow normally.

Vitamin B2 is also called riboflavin, which plays a very important role in the metabolism of the soft tissues of the human body. Some of the tissues can also replace other oxygen in the vicinity, helping to assimilate starch and sugar as well as metabolism. According to various scientific studies, if vitamin B 2 is not given, it will disappear and smooth hairs will become harsh, and it is reported that the period of new hair growth changes and hair loss begins.

Vitamin B6 is also called pyridoxine, and deficiency in animal experiments can hinder hair growth. At the same time, scaly dermatitis due to malnutrition occurs. This vitamin B6 is involved in the metabolism of protein, fat and carbohydrate, and it helps to the activity of the human body. In addition, it helps hematopoiesis, and it is important to maintain skin and nerve, muscular function.

Vitamin C, which is used as the antioxidant of the present invention, is also referred to as a bleeding inhibitor and inhibits the tendency of blood to be easily released from capillaries. The action of this vitamin is further enhanced by the presence of bioplaving. The connective tissue that binds the skin cells together is called collagen. Vitamin C is a vitamin necessary for the formation of this collagen. It is known as a vitamin that has defense against bacterial infectious diseases. It also inhibits the excessive production of histamine in the body. Vitamin C also acts to treat trauma quickly and helps to absorb iron from the intestinal tract.

Vitamin D maintains a balance of calcium in the body and can play an important role in the metabolism of phosphorus and the replacement of oxygen in the body.

Vitamin E acts as an integral element in muscle tissue and systemic vasculature. When these vitamins are scarce, red blood cells become very resistant and blood clots can clog blood clots.

Nicotinic acid helps blood circulation, has a brand name of niacin, and is one of the B vitamins. This chemical is needed to maintain normal function of skin, liver, nerve and circulatory tissues. It is also necessary for assimilation of starch and carbohydrates.

Pantothenic acid has been used as an anti-dermatological factor necessary for maintaining the health of the skin and as a substance necessary for maintaining the normal function of the adrenal gland.

Biotin acts to stimulate cell growth, and in animal experiments it has been known that deficiency of this material inhibits hair growth.

Currently, products that are marketed as hair growth promoting or hair loss preventing agents for various and complex hair loss causes include growth period induction effect, hair growth period extension effect, 5 alpha-reductase inhibition effect, blood circulation promotion effect, sterilization effect, dandruff prevention effect, , Antioxidant effect, and the like. However, these products are not effective in preventing hair loss, promoting hair growth, and have side effects. Also, because these products focused on only one or two hair growth mechanisms and were trying to improve them, they were not able to cope with various complicated mechanisms.

Accordingly, the present inventors confirmed that a hot distillation fraction rich in essential oil components, aromatic components, and antioxidant components can be obtained by cooling and recovering distillation components volatilized at a temperature above a certain temperature during ethanol extraction, and as a supplement, vitamins B1, B2 , Vitamin B6, vitamin C, vitamin D, vitamin E, nicotinic acid, pantothenic acid, biotin, and folic acid, and may contain a vitamin or vitamin precursor in the body to inhibit 5- The present invention relates to a hair growth composition which can be used for the treatment of male alopecia by preventing DHT from forming in the metabolic process of male hormone and helping the metabolism of hair by cell regeneration in the function of epithelial tissue of human body. A herbal cosmetic composition for preventing hair loss is developed and the present invention has been completed.

In view of the above problems of the prior art, the present invention provides a method for inhibiting the formation of DHT in the metabolic process of male hormone by inhibiting the 5-reductase in the body and inhibiting the metabolism of hair And to provide a hair growth composition which can be used for the treatment of alopecia areata.

Another object of the present invention is to provide a hair growth composition which is more fundamentally hair growth and promoting effect.

In order to accomplish the above object, the present invention provides a method for manufacturing a herbal cosmetic composition for protecting skin and scalp, preventing hair loss, comprising the following steps: to provide.

(a), hot water extraction by mixing ginseng, chrysanthemum root, ginseng, ginseng, peony, peony, yeast liquid, and sewage; And (b) obtaining a concentrated liquid produced by heating the hot-water extract to prepare a herbal cosmetic composition for skin and scalp protection and hair loss prevention, or

(a), hot water extraction of each of the first, second, third, and fourth ginsengs, ginseng, peonies, peonies, yeast extracts and hydrogen sulfide; And (b) heating the respective hot-water extracts to obtain a concentrate, and then mixing to prepare a herbal cosmetic composition for skin and scalp protection and hair loss prevention.

10 to 20 parts by weight, 10 to 20 parts by weight, 10 to 20 parts by weight, 10 to 20 parts by weight, 10 to 20 parts by weight, respectively, 10 to 20 parts by weight, 10 to 20 parts by weight, and 10 to 20 parts by weight of the composition.

Also included in the present invention is a vitamin or vitamin precursor selected from the group consisting of vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, nicotinic acid, pantothenic acid, biotin, .

As described above, the herbal cosmetic composition for protecting skin and scalp according to the present invention can prevent DHT from being formed in the metabolic process of male hormone by inhibiting the 5-reducing enzyme in the body, In the function of epithelial tissues, it can be used for the treatment of male alopecia by allowing the cell to regenerate the metabolism of hair by the cell regeneration.

In addition, various vitamins and vitamin precursors which help the metabolism of the human body are additionally included, so that the hair growth function of the composition exhibiting the synergistic effect can be further promoted.

1 is an SEM photograph of a hair.

In order to obtain the herbal hair cosmetic composition for prevention of hair loss, 167 g of Horseshoe radix, 166.5 g of Rhodiola, 166.5 g of Horseshoe chinensis, 166.5 g of Panax ginseng, 166.5 g of Peony root, 166.5 g of Peony root and 164.9 g of Hosoda were thoroughly washed with purified water and mixed . The hot water extract was obtained by heating in a hot water distiller at 40 to 45 ° C for about 8 to 48 hours using 20 L of ethanol. After extraction, the used herbal ingredients were removed and the hot water extract was heated at 40 to 45 캜 under reduced pressure, the solvent was removed using a cold water cooling tube at 4 to 10 캜, and the pressure was reduced to obtain a herbal composition concentrate. The obtained herbal composition was centrifuged at 12,000 rpm at 4 DEG C for 30 minutes to remove solid content, and the supernatant was used in the following experiment. The herbal compositions were obtained by first obtaining distilled liquids in the same manner as described above, and then mixing the same at the same ratio.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

[Example]

≪ Preparation of a herbal cosmetic composition for skin and scalp protection and hair loss prevention according to the present invention >

The herb raw materials used in the present invention include, but are not limited to, Candida, Rhodiola, Rhizoma, Ginseng, Peony, Peony, Yeast Extract, and Soda. As a first method, 1000 g of each of Hojiae, Rhodiola, Rhizoma, Ginseng, Peony, Moran and Sasa were sufficiently washed with purified water and mixed to obtain the herbal composition according to the present invention. The hot water extract was obtained by heating in a hot water distiller at 40 to 45 ° C for 8 to 48 hours using 20 L of purified water. After extraction, the used herbal extracts were removed and the hot-water extract was heated to 40-45 DEG C to obtain a concentrated herbal composition under reduced pressure. The obtained herbal composition was centrifuged at 12,000 rpm at 4 DEG C for 30 minutes to remove solid content, and the supernatant was obtained as a one-shot composition.

As a second method, a distillate of each one of the distillates was separately prepared, and the distillate composition thus obtained was mixed as described above or in an equal ratio. 1000 g of each of Horseshoe chinensis, Rhodiola, Rhizobia, Ginseng, Peonies, Peony, Yeast Extract, and Suseo were heated to 40 ~ 45 ℃ for 8 ~ 48 hours using 20 L of purified water to obtain hot water extract. After the extraction, the used herbal extracts were removed, and each of the hot-water extracts was heated to 40 to 45 ° C, and the solvent was removed using a cold water cooling tube at 4 to 10 ° C under reduced pressure, and each herbal distillate was obtained. Each of the obtained distillates was centrifuged at 12,000 rpm at 4 ° C for 30 minutes to remove insoluble solids. 1.665 L of the herbal extract, 1.665 L of the Hwangryeol distillate, 1.665 L of the Horseshoe extract, 1.665 L of the Ginseng Extract, 1.665 L of the Peony Extract, 1.645 L of the Peony Extract, and 1.665 L of the Soso Extract were mixed according to the composition table shown in Table 1 Respectively.

≪ Composition table of weight ratio of each component per 100 weight of the composition & S1 S2 S3 S4 S5 S6 S7 S8 Salicylic acid 0.2 0.2 0.2 0.2 0.25 0.25 0.25 0.25 D-panthenol 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 L-menthol 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 propylene glycol - 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Sodium hyaluronate - - 0.1 0.1 - - 0.1 0.1 Polysorbate 80 6 6 6 6 6.0 6.0 6.0 6.0 Ethanol 30 30 30 30 30 30 30 30 Oleic acid - - - 0.1 - 0.1 - 0.1 Urea - - - - - 1.0 - 0.5 Ho extract - - - - 5.0 5.0 2.0 2.0 Soso extract - - - - 5.0 5.0 5.0 5.0 Ginseng extract - - - - 5.0 5.0 5.0 5.0 Chrysanthemum extract - - - - - - 5.0 5.0 Peony extract - - - - - - 5.0 Peony extract - - - - - - 5.0 Vitamin E - - - - 0.1 0.1 0.2 0.2 Alkyl Trimethylammonium Chloride Solution - - 0.2 0.2 0.2 0.2 0.1 0.2 Lactic acid - - - Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Purified water Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount

<Experimental Example 1>

Male (C57BL, male) mice between 42 and 56 days of age were used to evaluate the induction of hair growth induction. First, the back hair was removed using an electric razor, and the weight of each mouse was measured. After the adaptation period for one week, 100 μL of the hair growth promoter composition was applied to the epilation area for the 30 days, starting from the next day. At this time, the hair growth promoter composition used was a solution having different kinds and concentrations, and the solution was prepared with the compositions of S5 to 8. Distilled water was used as a negative control.

As a result of the evaluation of the effectiveness of the hair growth promoting composition developed in this study, the hair growth of C57BL6 mouse was sufficiently promoted. In addition, the results of SEM and histological examination showed the hair growth effect. The following Tables 2 to 5 show the result of animal clinical examination and scanning electron microscope observation that the length and thickness of the simulated hair are superior to those of commercial products and that the surface of hair has regular shape of scales and clear boundary between scales.

Negative contrast S5 S6
start date

After 7 days

After 14 days

After 21 days

After 28 days

<Hair regrowth scoring index of oriental herb extract> Day Control group S5 S6 0 - - - 7 - - - 14 - + ± 21 - +++ + 28 ± +++ ++

* Hair regrowth scoring index: 0-20% (-), 20-40% (±), 40-60% (+), 60-80% (++), 80-100% (+++)

Negative contrast S7 S8
start date

After 7 days

After 14 days

After 21 days

After 31 days

<Hair regrowth scoring index of oriental herb extract> Day Control group S7 S8 0 - - - 7 - - - 14 - - - 24 ± ++ ++ 31 + +++ +++

* Hair regrowth scoring index: 0-20% (-), 20-40% (±), 40-60% (+), 60-80% (++), 80-100% (+++)

<Experimental Example 2>

The surface structure of hair was observed through a scanning electron microscope (SEM, HITACHI, S-2400). One strand of hair was fixed to the hair sample using a double sided tape, and then treated with a vacuum ion coater to prevent breakage of the hair under vacuum, and plated with platinum for precise observation at high resolution. The hair of the coated hair sample was placed in a chamber of a scanning electron microscope and the hair was observed at 2,000 times under a condition of 15 kV.

FIG. 1 is a result of SEM photographing after removing hair from each group of mice at 24 hours after application of S5 on day 17. The group consisted of negative control with distilled water only, S5 and S6 group developed in this study.

In S1 group, it was observed that the shape of the scale layer was not constant and very irregular. On the contrary, the hair surface of the positive control group S5 showed regular shape of scales and clear boundary between scales. In addition, the S5 and S6 groups showed that the scales were superimposed on each other in a smooth and calm manner.

These results suggest that the hair regenerated after application of the sample developed in this study is very healthy hair.

Claims (5)

A herbal cosmetic composition for protecting skin and scalp from hair loss, which comprises an extract of Chrysanthemum phalaenopsis, Rhodiola extract, ginseng extract, peony extract, peony extract and Sasa extract. The method according to claim 1,
Wherein the composition further comprises at least one vitamin or vitamin precursor selected from the group consisting of vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, nicotinic acid, pantothenic acid, and biotin. Of the present invention. The method according to claim 1,
The composition comprises 10-20 parts by weight of the herbal extract, 10-20 parts by weight of the Rhodiola extract, 10-20 parts by weight of the ginseng extract, 10-20 parts by weight of the peony extract, 10-20 parts by weight of the peony extract, Wherein the composition is added to the skin and scalp to prevent hair loss. Wherein the formulation of the composition according to any one of claims 1 to 3 is a lotion, cream, emulsion, essence or spray. (a), hot water extraction by mixing ginseng, ginseng, peony, peony and sewage; And (b) cooling the steam produced by heating the hot-water extract under reduced pressure to obtain a distilled liquid to produce a herbal cosmetic composition.

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